PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
26179904-4	2015	Similar to IL-1alpha, AS-IL1alpha is expressed at low levels in resting macrophages and is induced following infection with Listeria monocytogenes or stimulation with TLR ligands (Pam3CSK4, LPS, polyinosinic-polycytidylic acid).	Poly I-C	195-226	interleukin 1 alpha	Homo sapiens	25-33
26075680-3	2015	In the present study, dynamic light scattering (DLS) and molecular dynamics (MD) simulations were used for the investigation of the molecular diffusion in binary mixtures of the IL 1-ethyl-3-methylimidazolium tetracyanoborate ([EMIM][B(CN)4]) with the dissolved gases carbon dioxide, nitrogen, carbon monoxide, hydrogen, methane, oxygen, and hydrogen sulfide at temperatures from 298.15 to 363.15 K and pressures up to 63 bar.	ethyl-3-methylimidazolium tetracyanoborate	183-225	interleukin 1 alpha	Homo sapiens	178-182
25725559-0	2015	Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop.	Durapatite	28-42	interleukin 1 alpha	Homo sapiens	122-141
25870999-0	2015	Secreted IL-1alpha promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice.	Carbon Tetrachloride	88-108	interleukin 1 alpha	Homo sapiens	9-18
25528863-10	2015	Therefore, controlled trials are needed to evaluate the safety and long-term efficacy of IL-1 targeting agents in colchicine resistant patients.	Colchicine	114-124	interleukin 1 alpha	Homo sapiens	89-93
25888099-8	2015	Finally, IL-1 was validated with other general amino acids by the same procedures based on ATPS.	atps	91-95	interleukin 1 alpha	Homo sapiens	9-13
25791477-5	2015	Here, we show that BZ dramatically increases the IL-8 expression in lipopolysaccharide (LPS)-stimulated U937 macrophages as well as in unstimulated U937 monocytes and peripheral blood mononuclear cells, while it inhibits expression of IL-6, IL-1 and tumor necrosis factor-alpha.	Bortezomib	19-21	interleukin 1 alpha	Homo sapiens	241-277
26130346-10	2015	Significantly higher levels for IL-1ss, IL-5, IL-10 and GM-CSF were found in the subgroup of tissues from failed MoM THAs with a lymphocyte-dominated peri-prosthetic response compared with those without this response.	mom thas	113-121	interleukin 1 alpha	Homo sapiens	32-36
24807396-2	2015	This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-alpha, and IL-1ss compared with those patients receiving fentanyl alone (F).	flurbiprofen axetil	127-146	interleukin 1 alpha	Homo sapiens	242-246
24807396-2	2015	This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-alpha, and IL-1ss compared with those patients receiving fentanyl alone (F).	Fentanyl	176-184	interleukin 1 alpha	Homo sapiens	242-246
24807396-11	2015	CONCLUSION: In patients undergoing a mastectomy, postoperative analgesia with flurbiprofen axetil, combined with fentanyl, were associated with decreases in serum concentrations of VEGF-C, TNF-alpha, and IL-1ss compared with patients receiving doses of only fentanyl.	flurbiprofen axetil	78-97	interleukin 1 alpha	Homo sapiens	204-208
24807396-11	2015	CONCLUSION: In patients undergoing a mastectomy, postoperative analgesia with flurbiprofen axetil, combined with fentanyl, were associated with decreases in serum concentrations of VEGF-C, TNF-alpha, and IL-1ss compared with patients receiving doses of only fentanyl.	Fentanyl	113-121	interleukin 1 alpha	Homo sapiens	204-208
25864926-5	2015	IL-1alpha-positive cells were identified in the epithelium in human IBD and dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	76-98	interleukin 1 alpha	Homo sapiens	0-9
25864926-5	2015	IL-1alpha-positive cells were identified in the epithelium in human IBD and dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	100-103	interleukin 1 alpha	Homo sapiens	0-9
25777483-10	2015	Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1.	astaxanthine	15-26	interleukin 1 alpha	Homo sapiens	89-107
25777483-10	2015	Treatment with astaxanthin or withaferin A significantly reduced the increased levels of interleukin-1alpha, interleukin-6/8, granulocyte macrophage stimulatory factor and endothelin-1.	withaferin A	30-42	interleukin 1 alpha	Homo sapiens	89-107
25725559-10	2015	These data suggested that nHAp may exert osteoinductive effects on BMSCs via the secretion of IL-1alpha in an autocrine/paracrine fashion, and IL-1alpha activity could be regulated through the synthesis of IL1R2 by BMSCs upon interaction with nHAp.	N-hydroxy-2-aminopyrene	26-30	interleukin 1 alpha	Homo sapiens	94-103
25712126-9	2015	A time-dependent increase of IL1alpha but not IL1beta was observed in response to erlotinib treatment, and IL1alpha blockade significantly increased the antitumor activity of erlotinib and cetuximab in vivo.	Erlotinib Hydrochloride	82-91	interleukin 1 alpha	Homo sapiens	29-37
26604933-17	2015	Clodronate at small doses (2 mg) could also have protective effects on cartilage (introduction of intra-articular formulation is expected) and at 10-100 fold higher doses it has certainly anti-inflammatory effects and more specifically antimacrophage and anticytokine effects (IL-1, IL-6, TNFalpha, PGE).	Clodronic Acid	0-10	interleukin 1 alpha	Homo sapiens	277-281
26165106-8	2015	Agents blocking interleukin 1 (canakinumab) can be used in acute gout when NSAIDS and colchicine are contraindicated or not tolerated.	Colchicine	86-96	interleukin 1 alpha	Homo sapiens	16-29
25712126-9	2015	A time-dependent increase of IL1alpha but not IL1beta was observed in response to erlotinib treatment, and IL1alpha blockade significantly increased the antitumor activity of erlotinib and cetuximab in vivo.	Erlotinib Hydrochloride	175-184	interleukin 1 alpha	Homo sapiens	29-37
25712126-9	2015	A time-dependent increase of IL1alpha but not IL1beta was observed in response to erlotinib treatment, and IL1alpha blockade significantly increased the antitumor activity of erlotinib and cetuximab in vivo.	Erlotinib Hydrochloride	175-184	interleukin 1 alpha	Homo sapiens	107-115
25712126-10	2015	A pan-caspase inhibitor reduced erlotinib-induced IL1alpha secretion, suggesting that IL1alpha was released because of cell death.	Erlotinib Hydrochloride	32-41	interleukin 1 alpha	Homo sapiens	50-58
25712126-10	2015	A pan-caspase inhibitor reduced erlotinib-induced IL1alpha secretion, suggesting that IL1alpha was released because of cell death.	Erlotinib Hydrochloride	32-41	interleukin 1 alpha	Homo sapiens	86-94
25712126-12	2015	Overall, the IL1alpha/IL1R/MYD88/IL6 pathway may be responsible for the reduced antitumor efficacy of erlotinib and other EGFRIs, and blockade of IL1 signaling may improve the efficacy of EGFRIs in the treatment of HNSCC.	Erlotinib Hydrochloride	102-111	interleukin 1 alpha	Homo sapiens	13-21
25849717-7	2015	Thapsigargin, an ER stress activator, induced upregulated secretion of mature IL-1alpha and IL-1beta in human omental adipose tissue explants primed with bacterial endotoxin LPS, the viral dsRNA analogue poly(I:C) or the pro-inflammatory cytokine TNF-alpha.	Thapsigargin	0-12	interleukin 1 alpha	Homo sapiens	78-87
25853319-2	2015	Biocomposites with tuneable properties were successfully synthesized by ring-opening graft polymerization (ROGP) of propylene carbonate (PC) onto xylan using DBU as a catalyst in the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl).	propylene carbonate	137-139	interleukin 1 alpha	Homo sapiens	183-202
25849717-8	2015	Inhibition of capase-1 with Ac-YVAD-CHO resulted in decreased IL-1alpha and IL-1beta secretion, whereas inhibition of pannexin-1 with carbenoxolone suppressed IL-1beta secretion only.	L 709049	28-39	interleukin 1 alpha	Homo sapiens	62-71
25853319-2	2015	Biocomposites with tuneable properties were successfully synthesized by ring-opening graft polymerization (ROGP) of propylene carbonate (PC) onto xylan using DBU as a catalyst in the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl).	Xylans	146-151	interleukin 1 alpha	Homo sapiens	183-202
25853319-2	2015	Biocomposites with tuneable properties were successfully synthesized by ring-opening graft polymerization (ROGP) of propylene carbonate (PC) onto xylan using DBU as a catalyst in the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl).	1,8-diazabicyclo(5.4.0)undec-7-ene	158-161	interleukin 1 alpha	Homo sapiens	183-202
25853319-2	2015	Biocomposites with tuneable properties were successfully synthesized by ring-opening graft polymerization (ROGP) of propylene carbonate (PC) onto xylan using DBU as a catalyst in the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl).	allyl-3-methylimidazolium chloride	203-237	interleukin 1 alpha	Homo sapiens	183-202
25849717-9	2015	Treatment with anti-diabetic drugs metformin and glibenclamide also reduced IL-1alpha and IL-1beta secretion in infection and cytokine-primed adipose tissue.	Metformin	35-44	interleukin 1 alpha	Homo sapiens	76-85
25849717-9	2015	Treatment with anti-diabetic drugs metformin and glibenclamide also reduced IL-1alpha and IL-1beta secretion in infection and cytokine-primed adipose tissue.	Glyburide	49-62	interleukin 1 alpha	Homo sapiens	76-85
25575516-8	2015	Moreover, ATP increased P2Y2-mediated upregulation of MUC8 expression; however, IL-1alpha significantly decreased the extent to which ATP/P2Y2 upregulated MUC8 expression.	Adenosine Triphosphate	134-137	interleukin 1 alpha	Homo sapiens	80-89
25098424-0	2015	Significant decreases of interleukin-1alpha gene expression after application of the serotonin receptor antagonist ondansetron are found to correlate with antiproliferative properties in the acute lymphoblastic leukemia cell line REH.	Ondansetron	115-126	interleukin 1 alpha	Homo sapiens	25-43
25647343-10	2015	We suggest that escitalopram modulates the balance of IL-1 and IL-1 receptor antagonist and improves the function and number of T regulatory cells.	Citalopram	16-28	interleukin 1 alpha	Homo sapiens	54-58
25730877-5	2015	In CAPS monocytes, LPS induces the externalization of copious amounts of ATP (10-fold), which drive IL-1beta, IL-18, and IL-1alpha release via activation of the P2X purinoceptor 7.	Adenosine Triphosphate	73-76	interleukin 1 alpha	Homo sapiens	121-130
25518908-2	2015	Since the first anti-TNF-alpha therapies, numerous molecules have been identified as targets of immunomodulatory therapies, such as IL-1 (anakinra, canakinumab), IL-6 (tocilizumab), CD20(+) B cells (rituximab), CTLA4 (abatacept) and two additional anti-TNF-alpha therapies (certolizumab pegol, golimumab).	Certolizumab Pegol	274-292	interleukin 1 alpha	Homo sapiens	132-136
25642823-0	2015	IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.	Tretinoin	80-93	interleukin 1 alpha	Homo sapiens	0-4
25499119-4	2015	The level of SuPAR has been measured in PJI patients and healthy controls, correlated with canonical inflammatory markers, such as C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2.	supar	13-18	interleukin 1 alpha	Homo sapiens	157-174
25499119-5	2015	Serum suPAR displayed a strongly significative increase in PJI patients compared to not infected controls, and a significative positive correlation with C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2.	supar	6-11	interleukin 1 alpha	Homo sapiens	179-196
25688664-5	2015	Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFNgamma), and various chemotactic cytokines from SEB-stimulated human PBMC.	Sulfasalazine	0-13	interleukin 1 alpha	Homo sapiens	70-83
25973048-14	2015	After the expression of S100A12 in propylene glycol monomethyl ether acetate (PMA) induced human macrophages was silenced, the expression of proinflammatory factor IL-1, IL-6 and TNF-alpha was down-regulated.	2-methoxypropyl-1-acetate	35-76	interleukin 1 alpha	Homo sapiens	164-168
25139580-1	2015	Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs.	Colchicine	38-48	interleukin 1 alpha	Homo sapiens	124-142
25139580-1	2015	Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs.	Colchicine	38-48	interleukin 1 alpha	Homo sapiens	144-148
25139580-10	2015	Anti-IL-1 targeting drugs seem safe and effective therapies in colchicine-resistant FMF.	Colchicine	63-73	interleukin 1 alpha	Homo sapiens	5-9
25824798-5	2015	HT-29 cells demonstrated significantly increased RIPK1, RIPK3 and MLKL expression in response to cobalt chloride plus z-VAD treatment, which was accompanied by drastically increased IL1alpha and IL6 expression, substantiating the notion that necrosis can induce profound immune reactions.	cobaltous chloride	97-112	interleukin 1 alpha	Homo sapiens	182-190
25310769-15	2015	IL-1alpha and IL-1beta activity was increased in Cisplatin-treated PTs.	Cisplatin	49-58	interleukin 1 alpha	Homo sapiens	0-9
25439867-6	2015	When the hydrolysis of cellulose was catalyzed by 1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate (IL-1) and the dosage of water was 0.2g, the TRS yield was up to 85.1% within 60 min at 100 C. These new acidic ionic liquids catalysts are expected to have a wide application in the conversion of cellulose into valuable chemicals.	Cellulose	23-32	interleukin 1 alpha	Homo sapiens	111-115
25439867-6	2015	When the hydrolysis of cellulose was catalyzed by 1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate (IL-1) and the dosage of water was 0.2g, the TRS yield was up to 85.1% within 60 min at 100 C. These new acidic ionic liquids catalysts are expected to have a wide application in the conversion of cellulose into valuable chemicals.	1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate	50-109	interleukin 1 alpha	Homo sapiens	111-115
25439867-6	2015	When the hydrolysis of cellulose was catalyzed by 1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate (IL-1) and the dosage of water was 0.2g, the TRS yield was up to 85.1% within 60 min at 100 C. These new acidic ionic liquids catalysts are expected to have a wide application in the conversion of cellulose into valuable chemicals.	Water	135-140	interleukin 1 alpha	Homo sapiens	111-115
25439867-6	2015	When the hydrolysis of cellulose was catalyzed by 1-propyl sulfonic acid-2-phenyl imidazoline hydrogensulfate (IL-1) and the dosage of water was 0.2g, the TRS yield was up to 85.1% within 60 min at 100 C. These new acidic ionic liquids catalysts are expected to have a wide application in the conversion of cellulose into valuable chemicals.	Cellulose	307-316	interleukin 1 alpha	Homo sapiens	111-115
25824798-5	2015	HT-29 cells demonstrated significantly increased RIPK1, RIPK3 and MLKL expression in response to cobalt chloride plus z-VAD treatment, which was accompanied by drastically increased IL1alpha and IL6 expression, substantiating the notion that necrosis can induce profound immune reactions.	z-vad	118-123	interleukin 1 alpha	Homo sapiens	182-190
26090385-6	2015	Cytokine expression analysis in media of sepiolite NC treated cultures showed a proinflammatory profile (INFgamma, IL-1alpha, IL-8, and IL-6), in contrast with clinoptilolite NC that induced lees cytokines with concomitant production of IL-10.	magnesium trisilicate	41-50	interleukin 1 alpha	Homo sapiens	115-124
25764208-0	2015	Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	35-38	interleukin 1 alpha	Homo sapiens	152-161
26199639-6	2015	Moreover, bavachalcone suppressed senescence in human endothelial cells and mRNA expression of p16(ink4a) (a marker of replicative senescence) and IL-1alpha (a proinflammatory cytokine of the senescence-associated secretory phenotype).	bavachalcone	10-22	interleukin 1 alpha	Homo sapiens	147-156
25764208-4	2015	Here, we describe the generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) of the IgG1/k subtype that specifically and potently neutralizes IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	57-60	interleukin 1 alpha	Homo sapiens	178-187
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	30-39
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	99-108
25371321-2	2014	High loadings of the IL 1-methyl-3-butylimidazolium bis(trifluoromethylsulfonyl)imide ([C4MIM][TFSI]) were confined within the hybrid network.	methyl-3-butylimidazolium bis(trifluoromethylsulfonyl)imide	26-85	interleukin 1 alpha	Homo sapiens	21-25
25790671-0	2015	[Effect of Sanhuang Yilong Decoction combined MTX on the expression of serum IL-1, IL-6, and IL-17 in rheumatoid arthritis patients of accumulated dampness-heat syndrome].	Methotrexate	46-49	interleukin 1 alpha	Homo sapiens	77-81
25790671-1	2015	OBJECTIVE: To study the effect of bitter-cold herbs easing dampness method (BCHEDM) plus Sanhuang Yilong Decoction (SYD) combined with methotrexate (MTX) on expression levels of interleukin-1 (IL-1), IL-6, and IL-17 in rheumatoid arthritis (RA) patients of accumulated dampness-heat syndrome (ADHS).	Methotrexate	149-152	interleukin 1 alpha	Homo sapiens	193-197
25790671-9	2015	CONCLUSION: SYD combined MTX could play roles of improving inflammatory indices within 2 weeks, and inhibiting the expression of IL-1, IL-6, and IL-17 within 4 weeks.	Methotrexate	25-28	interleukin 1 alpha	Homo sapiens	129-133
25598661-0	2014	FSL-1, a Toll-like Receptor 2/6 Agonist, Induces Expression of Interleukin-1alpha in the Presence of 27-hydroxycholesterol.	27-hydroxycholesterol	101-122	interleukin 1 alpha	Homo sapiens	63-81
25290854-5	2014	CA and control sensitizers nickel sulphate (NiSO4) and 1-chloro-2,4-dinitrochlorobenzene (DNCB) released lower levels of IL-1alpha than CPC and control irritant benzalkonium chloride (BC), whereas the opposite was observed for IL-8.	nickel sulfate	27-42	interleukin 1 alpha	Homo sapiens	121-130
25290854-5	2014	CA and control sensitizers nickel sulphate (NiSO4) and 1-chloro-2,4-dinitrochlorobenzene (DNCB) released lower levels of IL-1alpha than CPC and control irritant benzalkonium chloride (BC), whereas the opposite was observed for IL-8.	nickel sulfate	44-49	interleukin 1 alpha	Homo sapiens	121-130
25290854-5	2014	CA and control sensitizers nickel sulphate (NiSO4) and 1-chloro-2,4-dinitrochlorobenzene (DNCB) released lower levels of IL-1alpha than CPC and control irritant benzalkonium chloride (BC), whereas the opposite was observed for IL-8.	1,3-Dichloro-2,4-dinitrobenzene	55-88	interleukin 1 alpha	Homo sapiens	121-130
25290854-5	2014	CA and control sensitizers nickel sulphate (NiSO4) and 1-chloro-2,4-dinitrochlorobenzene (DNCB) released lower levels of IL-1alpha than CPC and control irritant benzalkonium chloride (BC), whereas the opposite was observed for IL-8.	Dinitrochlorobenzene	90-94	interleukin 1 alpha	Homo sapiens	121-130
25598661-3	2014	Addition of FSL-1, a TLR6 agonist, to 27OHChol-treated cells resulted in transcription of the IL-1alpha gene and enhanced secretion of the corresponding gene product.	27ohchol	38-46	interleukin 1 alpha	Homo sapiens	94-103
25598661-6	2014	Treatment with Akt inhibitor IV or U0126 resulted in significantly attenuated expression of TLR6 and IL-1alpha induced by 27OHChol and 27OHChol plus FSL-1, respectively.	U 0126	35-40	interleukin 1 alpha	Homo sapiens	101-110
25598661-6	2014	Treatment with Akt inhibitor IV or U0126 resulted in significantly attenuated expression of TLR6 and IL-1alpha induced by 27OHChol and 27OHChol plus FSL-1, respectively.	27ohchol	122-130	interleukin 1 alpha	Homo sapiens	101-110
25598661-6	2014	Treatment with Akt inhibitor IV or U0126 resulted in significantly attenuated expression of TLR6 and IL-1alpha induced by 27OHChol and 27OHChol plus FSL-1, respectively.	27ohchol	135-143	interleukin 1 alpha	Homo sapiens	101-110
25598661-7	2014	In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	interleukin 1 alpha	Homo sapiens	110-119
25598661-7	2014	In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1alpha.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	38-46	interleukin 1 alpha	Homo sapiens	110-119
25598661-7	2014	In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1alpha.	pyrazolanthrone	51-59	interleukin 1 alpha	Homo sapiens	110-119
25598661-8	2014	These results indicate that 27OHChol can induce inflammation by augmentation of TLR6-mediated production of IL-1alpha in monocytic cells via multiple signaling pathways.	27ohchol	28-36	interleukin 1 alpha	Homo sapiens	108-117
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	95-99	interleukin 1 alpha	Homo sapiens	19-37
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	95-99	interleukin 1 alpha	Homo sapiens	39-48
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	95-99	interleukin 1 alpha	Homo sapiens	101-110
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	19-37
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	39-48
25160895-13	2014	A candesartan-induced decrease in VEGF and IL-1beta may be responsible for the beneficial effects, suggesting the brain RAS as a new target for LID treatment in PD patients.	candesartan	2-13	interleukin 1 alpha	Homo sapiens	43-51
25288220-7	2014	Ex vivo, AZD9056 inhibited IL-1 and IL-18 release to BzATP in LPS-primed human monocytes.	AZD9056	9-16	interleukin 1 alpha	Homo sapiens	27-31
25275022-0	2014	Differential expression of VEGF and IL-1alpha after photodynamic treatment in combination with doxorubicin or taxotere.	Doxorubicin	95-106	interleukin 1 alpha	Homo sapiens	36-45
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	8-12
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	58-62
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	58-62
24758886-8	2014	Recently, reports for four trials described the efficacy of canakinumab and rilonacept, two IL-1 inhibitors, for preventing flares during the initiation of allopurinol therapy.	Allopurinol	156-167	interleukin 1 alpha	Homo sapiens	92-96
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	101-110
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	19-37
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	39-48
25425967-6	2014	We also found that interleukin-1alpha (IL-1alpha) secreted from OSCC cells had dual effects on CAFs: IL-1alpha not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8.	cafs	150-154	interleukin 1 alpha	Homo sapiens	101-110
25425967-8	2014	In summary, we unraveled an important interactive mechanism of carcinogenesis: IL-1alpha released from carcinoma stimulates the proliferation of CAFs and the simultaneous increase in cytokine secretion from CAFs promotes cancer progression in human OSCC.	cafs	145-149	interleukin 1 alpha	Homo sapiens	79-88
25275022-0	2014	Differential expression of VEGF and IL-1alpha after photodynamic treatment in combination with doxorubicin or taxotere.	Docetaxel	110-118	interleukin 1 alpha	Homo sapiens	36-45
25275022-6	2014	The expression of IL-1alpha and VEGF was up-regulated in PDT-treated cells, either alone or in combination with doxorubicin or taxotere.	Doxorubicin	112-123	interleukin 1 alpha	Homo sapiens	18-27
25275022-6	2014	The expression of IL-1alpha and VEGF was up-regulated in PDT-treated cells, either alone or in combination with doxorubicin or taxotere.	Docetaxel	127-135	interleukin 1 alpha	Homo sapiens	18-27
25275022-7	2014	Addition of doxorubicin to the cytokine induction after PDT was not detected, however, taxotere promoted significant over-expression of IL-1alpha and VEGF on the protein level.	Docetaxel	87-95	interleukin 1 alpha	Homo sapiens	136-145
25103574-7	2014	The enrichment of H3K4me2 marks was 11-137 % greater in riboflavin-deficient cells compared with sufficient cells in exon 1 of genes coding for the pro-inflammatory cytokines interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha.	Riboflavin	56-66	interleukin 1 alpha	Homo sapiens	175-198
24283398-6	2014	Of the inflammatory mediators/acute phase proteins, only IL-1ss levels were positively associated (p < 0.001) with the pack years and cotinine levels.	Cotinine	137-145	interleukin 1 alpha	Homo sapiens	57-61
23824148-6	2014	IL-1 alpha, IL-1beta and IL-6 levels were reduced by 1,25(OH) 2D3 at higher concentrations in all cell populations.	(oh) 2d3	57-65	interleukin 1 alpha	Homo sapiens	0-10
25237386-8	2014	Employing HeLa (adenocarcinoma) cell line as a model system we identified PGE2 and EGF as possible ligands responsible for SP-mediated induction of IL-1alpha in these neoplastic cells.	Dinoprostone	74-78	interleukin 1 alpha	Homo sapiens	148-157
24274595-5	2014	Compared with macrophages from healthy subjects, CCPA macrophages showed unrestrained rises in IL1A, IL1B, IL6, IRAK2 and TRAF6 throughout the experiment, and a lack of expression of TGFB1 at 9 h. Single nucleotide polymorphisms (SNPs) associated with CCPA were found in IL1B (n = 2), IL1RN and IL15 (n = 3).	2-chloro-N(6)cyclopentyladenosine	49-53	interleukin 1 alpha	Homo sapiens	95-99
24990750-5	2014	Here we demonstrate that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment.	Eicosanoids	95-106	interleukin 1 alpha	Homo sapiens	40-44
25126080-6	2014	Using fetal membranes explants we tested the effect of cytokines (interleukin-1 and tumor necrosis factor alpha) on PG production and the concomitant changes in cyclooxygenase-2 (PTGS2), AKR1B1 and SLCO2A1 expression.	Prostaglandins	116-118	interleukin 1 alpha	Homo sapiens	66-111
25070190-9	2014	RESULTS: It was found that TNF-alpha could be significantly suppressed by ACE extracts, whereas IL-1 was dramatically inhibited by BU extracts, which was further confirmed by dose-dependent experiments.	1-Butanol	131-133	interleukin 1 alpha	Homo sapiens	96-100
24917666-8	2014	Finally, acting as a physiological analog of rapamycin, IL-1beta impaired BDNF signaling by way of inhibiting mTOR activation as follows: the cytokine induced caspase-independent neuronal death and accelerated autophagic flux in BDNF-treated cells.	Sirolimus	45-54	interleukin 1 alpha	Homo sapiens	56-64
24990750-6	2014	We further show that, in infected mice and patients, reduced IL-1 responses and/or excessive type I IFN induction are linked to an eicosanoid imbalance associated with disease exacerbation.	Eicosanoids	131-141	interleukin 1 alpha	Homo sapiens	61-65
24990750-8	2014	Thus, IL-1 and type I IFNs represent two major counter-regulatory classes of inflammatory cytokines that control the outcome of Mtb infection and are functionally linked via eicosanoids.	Eicosanoids	174-185	interleukin 1 alpha	Homo sapiens	6-10
24591481-0	2014	Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1.	Palmitates	0-9	interleukin 1 alpha	Homo sapiens	98-111
24944594-7	2014	The expression levels of intracellular adhesion molecule-1, vascular adhesion molecule-1, interleukin-1 and -6 and nuclear factor-kappaB decreased, while the expression levels of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 increased with XMJ administration.	4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE	265-268	interleukin 1 alpha	Homo sapiens	25-110
24799081-6	2014	The IC50 value of A. paniculata extract was significantly higher than that of andrographolide on IL-1alpha, IL-1beta, and IL-6 (p < 0.001) release.	andrographolide	78-93	interleukin 1 alpha	Homo sapiens	97-106
24799081-7	2014	The IC50 values of andrographolide for IL-1alpha, IL-1beta, and IL-6 were significantly higher (p < 0.001) than that of dexamethasone.	andrographolide	19-34	interleukin 1 alpha	Homo sapiens	39-48
24799081-9	2014	To our knowledge, this is the first report that A. paniculata extract and its major compound andrographolide strongly inhibited the release of IL-1alpha, whereas previous studies only showed their inhibitory effect on the release of another IL-1 family member, IL-1beta.	andrographolide	93-108	interleukin 1 alpha	Homo sapiens	143-152
24458363-5	2014	The endogenous oils were capable of promoting interleukin (IL)-1alpha-dependent recruitment of neutrophils and M1-like macrophages, while simultaneously diminishing M2-like macrophages.	Oils	15-19	interleukin 1 alpha	Homo sapiens	46-69
24760564-4	2014	METHODS: Zirconium fluoroanions were prepared using the fluorinating ionic liquid (IL) 1-ethyl-3-methylimidazolium fluorohydrogenate, which was used to generate abundant [ZrF5](-) ions using electrospray ionization.	zirconium fluoroanions	9-31	interleukin 1 alpha	Homo sapiens	69-88
24760564-4	2014	METHODS: Zirconium fluoroanions were prepared using the fluorinating ionic liquid (IL) 1-ethyl-3-methylimidazolium fluorohydrogenate, which was used to generate abundant [ZrF5](-) ions using electrospray ionization.	fluorinating	56-68	interleukin 1 alpha	Homo sapiens	69-88
24760564-4	2014	METHODS: Zirconium fluoroanions were prepared using the fluorinating ionic liquid (IL) 1-ethyl-3-methylimidazolium fluorohydrogenate, which was used to generate abundant [ZrF5](-) ions using electrospray ionization.	ethyl-3-methylimidazolium fluorohydrogenate	89-132	interleukin 1 alpha	Homo sapiens	69-88
24857488-1	2014	In this paper a novel sensing platform based on graphene oxide (GO), ionic liquid (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate and Nafion for the immobilization of hemoglobin (Hb) was adopted with a carbon ionic liquid electrode (CILE) as the substrate electrode, which was denoted as Nafion/Hb-GO-IL/CILE.	ethyl-3-methylimidazolium tetrafluoroborate	89-132	interleukin 1 alpha	Homo sapiens	69-88
24857488-1	2014	In this paper a novel sensing platform based on graphene oxide (GO), ionic liquid (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate and Nafion for the immobilization of hemoglobin (Hb) was adopted with a carbon ionic liquid electrode (CILE) as the substrate electrode, which was denoted as Nafion/Hb-GO-IL/CILE.	Carbon	205-211	interleukin 1 alpha	Homo sapiens	69-88
24857488-1	2014	In this paper a novel sensing platform based on graphene oxide (GO), ionic liquid (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate and Nafion for the immobilization of hemoglobin (Hb) was adopted with a carbon ionic liquid electrode (CILE) as the substrate electrode, which was denoted as Nafion/Hb-GO-IL/CILE.	cile	236-240	interleukin 1 alpha	Homo sapiens	69-88
24857488-1	2014	In this paper a novel sensing platform based on graphene oxide (GO), ionic liquid (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate and Nafion for the immobilization of hemoglobin (Hb) was adopted with a carbon ionic liquid electrode (CILE) as the substrate electrode, which was denoted as Nafion/Hb-GO-IL/CILE.	cile	307-311	interleukin 1 alpha	Homo sapiens	69-88
24643869-7	2014	A consistently positive relationship was found between dandruff, itching, erythema and Malassezia populations, histamine levels and IL-1RA/IL-1alpha ratio.	Histamine	111-120	interleukin 1 alpha	Homo sapiens	139-148
24458363-9	2014	In summary, this study shows that adipocytes contain a potent oil adjuvant which drives IL-1alpha-dependent proinflammatory responses in vivo.	Oils	62-65	interleukin 1 alpha	Homo sapiens	88-97
24953430-13	2014	In particular, the inflammation biomarkers C-reactive protein, IL-6, and IL-1alpha could indicate the prognostic benefit of gemcitabine chemotherapy and should now be tested in prospective patient-controlled trials.	gemcitabine	124-135	interleukin 1 alpha	Homo sapiens	73-82
24412833-8	2014	TNF-alpha and IL-1alpha were increased significantly in human PCLS after exposure to the respiratory sensitizers trimellitic anhydride (TMA) and ammonium hexachloroplatinate (HClPt) at subtoxic concentrations, while contact sensitizers and non-sensitizing irritants failed to induce the release of these cytokines to the same extent.	trimellitic anhydride	113-134	interleukin 1 alpha	Homo sapiens	14-23
24412833-8	2014	TNF-alpha and IL-1alpha were increased significantly in human PCLS after exposure to the respiratory sensitizers trimellitic anhydride (TMA) and ammonium hexachloroplatinate (HClPt) at subtoxic concentrations, while contact sensitizers and non-sensitizing irritants failed to induce the release of these cytokines to the same extent.	ammonium hexachloroplatinate	145-173	interleukin 1 alpha	Homo sapiens	14-23
24530664-14	2014	These data suggest a clinically relevant biological link between pro-inflammatory IL-1 genotype, oxidation of phospholipids, Lp(a), and genetic predisposition to CAD and cardiovascular events.	Phospholipids	110-123	interleukin 1 alpha	Homo sapiens	82-86
24667287-7	2014	When colchicine fails, IL-1 blockade is effective.	Colchicine	5-15	interleukin 1 alpha	Homo sapiens	23-27
24667287-13	2014	IL-1 blockade appears effective, but larger prospective trials are needed, especially in MKD, TRAPS and colchicine-resistant FMF patients.	Colchicine	104-114	interleukin 1 alpha	Homo sapiens	0-4
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	50-81	interleukin 1 alpha	Homo sapiens	124-133
24172847-5	2014	Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors.	Poly I-C	83-91	interleukin 1 alpha	Homo sapiens	124-133
24782683-10	2014	Additionally, interleukin-1 blockade appears to be effective treatment of macrophage activation syndrome, one of the most dangerous complications of JIA; specifically, anakinra in combination with cyclosporine and corticosteroids may obviate the need for cytotoxic approaches.	Cyclosporine	197-209	interleukin 1 alpha	Homo sapiens	14-27
24400695-7	2014	IL-1alpha reversibly stabilized Mg(2+) inhibition of Ca(2+) release.	magnesium ion	32-38	interleukin 1 alpha	Homo sapiens	0-9
24400695-8	2014	Low Mg(2+)-induced force and Ca(2+) transients were reversibly abolished by IL-1alpha.	magnesium ion	4-10	interleukin 1 alpha	Homo sapiens	76-85
24400695-9	2014	At normal Mg(2+), IL-1alpha reversibly increased caffeine-induced force and Ca(2+) transients.	magnesium ion	10-16	interleukin 1 alpha	Homo sapiens	18-27
24400695-9	2014	At normal Mg(2+), IL-1alpha reversibly increased caffeine-induced force and Ca(2+) transients.	Caffeine	49-57	interleukin 1 alpha	Homo sapiens	18-27
24400695-10	2014	IL-1alpha reduced SR Ca(2+) leak via RyR1, as judged by (1) increased SR Ca(2+) retention, (2) increased IL-1alpha force transients being reproduced by 25 muM tetracaine, and (3) reduced Ca(2+) spark frequencies by IL-1alpha or tetracaine.	Tetracaine	159-169	interleukin 1 alpha	Homo sapiens	0-9
24400695-10	2014	IL-1alpha reduced SR Ca(2+) leak via RyR1, as judged by (1) increased SR Ca(2+) retention, (2) increased IL-1alpha force transients being reproduced by 25 muM tetracaine, and (3) reduced Ca(2+) spark frequencies by IL-1alpha or tetracaine.	Tetracaine	159-169	interleukin 1 alpha	Homo sapiens	105-114
24400695-10	2014	IL-1alpha reduced SR Ca(2+) leak via RyR1, as judged by (1) increased SR Ca(2+) retention, (2) increased IL-1alpha force transients being reproduced by 25 muM tetracaine, and (3) reduced Ca(2+) spark frequencies by IL-1alpha or tetracaine.	Tetracaine	159-169	interleukin 1 alpha	Homo sapiens	105-114
24400695-10	2014	IL-1alpha reduced SR Ca(2+) leak via RyR1, as judged by (1) increased SR Ca(2+) retention, (2) increased IL-1alpha force transients being reproduced by 25 muM tetracaine, and (3) reduced Ca(2+) spark frequencies by IL-1alpha or tetracaine.	Tetracaine	228-238	interleukin 1 alpha	Homo sapiens	0-9
24451032-1	2014	The role of interleukin-1 (IL-1) in inflammation induced by crystals, and especially by monosodium urate crystals (MSUCs), has raised much interest in both basic and clinical investigation.	Uric Acid	88-104	interleukin 1 alpha	Homo sapiens	12-25
24332681-4	2014	Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines.	Silicon Dioxide	29-35	interleukin 1 alpha	Homo sapiens	267-276
24451032-1	2014	The role of interleukin-1 (IL-1) in inflammation induced by crystals, and especially by monosodium urate crystals (MSUCs), has raised much interest in both basic and clinical investigation.	Uric Acid	88-104	interleukin 1 alpha	Homo sapiens	27-31
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	133-151
24418674-2	2014	METHODS: Intracellular calcium transient responses to IL-1 and TGF-beta1 were measured in wild type and integrin alpha1-null chondrocytes using real time ex vivo confocal microscopy, and immunohistochemistry was performed to analyze TGF-beta1-mediated activation of Smad2/3 in tibial and femoral chondrocytes.	Calcium	23-30	interleukin 1 alpha	Homo sapiens	54-58
24418674-3	2014	RESULTS: Loss of integrin alpha1beta1 reduces intracellular calcium transient response to IL-1, while it enhances chondrocyte responses to TGF-beta1 as measured by intracellular calcium transients and activation of downstream Smad2/3.	Calcium	60-67	interleukin 1 alpha	Homo sapiens	90-94
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	153-162
24649404-4	2014	Ursolic acid markedly inhibited the IL-1alpha-induced cell-surface ICAM-1 expression in human cancer cell lines and human umbilical vein endothelial cells.	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	36-45
24649404-5	2014	By contrast, ursolic acid exerted weak inhibitory effects on the IL-1alpha-induced ICAM-1 expression at the protein level.	ursolic acid	13-25	interleukin 1 alpha	Homo sapiens	65-74
24515444-3	2014	Diacerein is an anthraquinone synthesised in 1980 that interferes with interleukin-1, an inflammatory mediator.	diacerein	0-9	interleukin 1 alpha	Homo sapiens	71-84
24515444-3	2014	Diacerein is an anthraquinone synthesised in 1980 that interferes with interleukin-1, an inflammatory mediator.	Anthraquinones	16-29	interleukin 1 alpha	Homo sapiens	71-84
24316253-5	2014	In the case of TNF-alpha, IL-1ss and PGE(2) a decreased level of secretion was observed 154 rhog/ml, 736.1 rhog/ml, and 151 rhog/ml respectively when compared with lipopolysaccharide treated cells, where the level of these cytokines was significantly high.	Prostaglandins E	37-40	interleukin 1 alpha	Homo sapiens	26-30
24333294-7	2014	HOC were cultured and stimulated with the catabolic cytokine IL-1alpha.	(2S)-2-HYDROXYOCTANOIC ACID	0-3	interleukin 1 alpha	Homo sapiens	61-70
24054992-4	2014	Here we investigated and identified that palmitate induced the activation of ice protease-activating factor (IPAF)-apoptosis-associated speck-like protein containing a caspase activation and recruitment domains (CARD) (ASC) inflammasome in astrocytes leading to the maturation of IL-1beta, thereby implicating that not only pathogen-related factors can activate the IPAF-ASC inflammasome.	Palmitates	41-50	interleukin 1 alpha	Homo sapiens	280-288
24054992-5	2014	Moreover, downregulating IPAF (which was found to be regulated by cAMP response element-binding protein) in astrocytes through silencing to decrease IL-1beta secretion from the astrocytes reduced the generation of amyloid-beta42 by primary neurons.	Cyclic AMP	66-70	interleukin 1 alpha	Homo sapiens	149-157
24622832-11	2014	Statistically significantly lower levels of IL-1, IL-6 and TNF-alpha were observed in patients receiving melatonin and tryptophan, comparing with group III treated with Essentiale forte only.	Melatonin	105-114	interleukin 1 alpha	Homo sapiens	44-48
24622832-11	2014	Statistically significantly lower levels of IL-1, IL-6 and TNF-alpha were observed in patients receiving melatonin and tryptophan, comparing with group III treated with Essentiale forte only.	Tryptophan	119-129	interleukin 1 alpha	Homo sapiens	44-48
25382335-10	2014	The mRNA expressions of IL-1alpha, IL-6, IL-8, and TNF-a in different concentrations of SDBS at different time were comparable with that of controls.	dodecylbenzenesulfonic acid	88-92	interleukin 1 alpha	Homo sapiens	24-33
24683393-10	2014	CONCLUSIONS: Measurements of IL-1alpha, IL-1beta and TNF-alpha sera concentrations could be assessed in parallel to the improvement of the clinical condition and can constitute a good indication of the efficiency of the isotretinoin treatment.	Isotretinoin	220-232	interleukin 1 alpha	Homo sapiens	29-38
24444433-0	2014	Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937.	Methotrexate	0-12	interleukin 1 alpha	Homo sapiens	35-39
24444433-8	2014	RESULTS: MTX mediated a dose-dependent increase in IL-1 and IL-6 in U937 cells, as measured by secreted proteins and levels of gene expression.	Methotrexate	9-12	interleukin 1 alpha	Homo sapiens	51-55
24588826-3	2014	These aspects are complementary because stimulatory actions of IL-1 may be due to its capacity to increase glucose uptake by immune cells in the periphery and to affect the control of glucose homeostasis at brain levels, so as to deviate this main fuel to immune cells during inflammatory and infectious diseases.	Glucose	107-114	interleukin 1 alpha	Homo sapiens	63-67
24588826-6	2014	During obesity, products of enlarged adipocytes, e.g. fatty acids, are sensed as danger signals by infiltrating immune cells and, together with hypoxia, results in an ectopic overproduction of IL-1 that is largely mediated by activation of the NLRP3-caspase-1 inflammasome.	Fatty Acids	54-65	interleukin 1 alpha	Homo sapiens	193-197
24671843-9	2014	In these patients, we observed that the switching from Bic-HD to HFR allowed an improvement of inflammatory as testified by a significant decrement of serum levels of CRP IL-6, IL-1 and TNF- and a significant increase of albumin and pre-albumin.	imidazole mustard	55-58	interleukin 1 alpha	Homo sapiens	177-181
24243637-9	2014	Treatment of adipocyte fractions or SGBS adipocytes with metformin or acetylsalicylic acid, which target C/EBPbeta and NF-kappaB/RelA signaling, attenuated the IL-1alpha induction of 11beta-HSD1 (P<=.002).	Metformin	57-66	interleukin 1 alpha	Homo sapiens	160-169
24243637-9	2014	Treatment of adipocyte fractions or SGBS adipocytes with metformin or acetylsalicylic acid, which target C/EBPbeta and NF-kappaB/RelA signaling, attenuated the IL-1alpha induction of 11beta-HSD1 (P<=.002).	Aspirin	70-90	interleukin 1 alpha	Homo sapiens	160-169
24908312-2	2014	The described protocol has been optimized for IL-1 detection in formalin-fixed paraffin-embedded oral tissue sections by light microscopy.	Formaldehyde	64-72	interleukin 1 alpha	Homo sapiens	46-50
24908312-2	2014	The described protocol has been optimized for IL-1 detection in formalin-fixed paraffin-embedded oral tissue sections by light microscopy.	Paraffin	79-87	interleukin 1 alpha	Homo sapiens	46-50
24357806-6	2013	The caspase-1 inhibitor Z-YVAD-FMK inhibits the processing of IL-1beta, and attenuates microglial neurotoxicity.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	24-34	interleukin 1 alpha	Homo sapiens	62-70
23742958-7	2013	In case of persistent attacks (>=6 per year) in patients with maximum doses of colchicine (2 mg in children; 3 mg in adults), alternative treatment to colchicine with IL1 inhibitors should be considered.	Colchicine	154-164	interleukin 1 alpha	Homo sapiens	170-173
24206661-3	2013	(2013) now suggest that IL-1alpha, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.	Fatty Acids	79-90	interleukin 1 alpha	Homo sapiens	24-33
24283773-3	2013	The aim of this study is to evaluate the effect of Methotrexate (MTX) on IL-1 alpha and IL-1 beta levels in both plasma and skin biopsy of patients with psoriasis and to investigate their association with clinical disease activity.	Methotrexate	51-63	interleukin 1 alpha	Homo sapiens	73-83
24283773-3	2013	The aim of this study is to evaluate the effect of Methotrexate (MTX) on IL-1 alpha and IL-1 beta levels in both plasma and skin biopsy of patients with psoriasis and to investigate their association with clinical disease activity.	Methotrexate	65-68	interleukin 1 alpha	Homo sapiens	73-83
24283773-11	2013	IL-1 alpha level in plasma and skin biopsy was reduced at day 0 sample and elevated significantly (P < 0.001) after MTX treatment.	Methotrexate	119-122	interleukin 1 alpha	Homo sapiens	0-10
24283773-13	2013	IL-1alpha levels and PASI score showed inverse correlation score before and after treatment with MTX.	Methotrexate	97-100	interleukin 1 alpha	Homo sapiens	0-9
24062309-4	2013	We established that SA shifts in steady-state H2O2 and intracellular Ca(2+) levels caused an increase in IL-1alpha expression and processing.	sa	20-22	interleukin 1 alpha	Homo sapiens	105-114
24062309-4	2013	We established that SA shifts in steady-state H2O2 and intracellular Ca(2+) levels caused an increase in IL-1alpha expression and processing.	Hydrogen Peroxide	46-50	interleukin 1 alpha	Homo sapiens	105-114
24062309-6	2013	Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8.	Oxygen	21-27	interleukin 1 alpha	Homo sapiens	49-58
24062309-10	2013	Collectively, these findings demonstrate how SA alterations in the redox state and Ca(2+) homeostasis modulate the inflammatory phenotype through the regulation of the SASP initiator IL-1alpha, creating a microenvironment permissive to tumor invasion.	sa	45-47	interleukin 1 alpha	Homo sapiens	183-192
24080250-9	2013	Montelukast significantly suppressed the release of IL-8 (p = 0.016), IL-6 (p = 0.006), RANTES (p = 0.002) and IFN-gamma (p = 0.046), in a dose dependent manner in unstimulated cultures but not in those stimulated with IL-1/TNF.	montelukast	0-11	interleukin 1 alpha	Homo sapiens	219-223
24076166-10	2013	Carbocysteine in CSE stimulated bronchial epithelial cells, reduced: (1) TLR4, LPS binding and p21; (2) IL-8 mRNA and IL-8 release due to IL-1 stimulation; (3) neutrophil chemotactic migration.	Carbocysteine	0-13	interleukin 1 alpha	Homo sapiens	138-142
24244740-0	2013	A role for interleukin-1 alpha in the 1,25 dihydroxyvitamin D3 response in mammary epithelial cells.	Calcitriol	38-62	interleukin 1 alpha	Homo sapiens	11-30
24244740-7	2013	Furthermore, 1,25(OH)2D3 increased the intracellular expression of IL1alpha, which was necessary for the anti-proliferative effects of 1,25(OH)2D3 in mammary cells.	Calcitriol	13-24	interleukin 1 alpha	Homo sapiens	67-75
24244740-7	2013	Furthermore, 1,25(OH)2D3 increased the intracellular expression of IL1alpha, which was necessary for the anti-proliferative effects of 1,25(OH)2D3 in mammary cells.	Calcitriol	135-146	interleukin 1 alpha	Homo sapiens	67-75
23623504-2	2013	We investigated the effects of valproic acid (VPA) and topiramate (TPM) on the blood levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and TNF-alpha in children with idiopathic generalized and partial epilepsy.	Topiramate	55-65	interleukin 1 alpha	Homo sapiens	95-118
23370294-6	2013	Median serum levels of cytokines IL-1alpha, IL-1beta, IL-1Ra, IL-6 and TNF-alpha in the OSFE group were: 1.077, 1.745, 25.640, 0.602 and 12.768 pg/ml, respectively.	osfe	88-92	interleukin 1 alpha	Homo sapiens	33-42
23370294-7	2013	These values in normal controls were 1.889, 1.896, 32.190, 1.022 and 23.786 pg/ml, respectively which are higher than the corresponding values in the OSFE group, the differences were statistically significant only for IL-1alpha and TNF-alpha.	osfe	150-154	interleukin 1 alpha	Homo sapiens	218-227
23375935-2	2013	In this preliminary study, the levels of IL-1alpha and beta, TNF, IL-1Ra, IL-6 and fibrinogen in the spontaneous sputum of SM-exposed individuals were examined 20 years after exposure and the correlation with pulmonary function was tested.	Mustard Gas	123-125	interleukin 1 alpha	Homo sapiens	41-50
23469836-4	2013	Increased levels of ROS stimulate proinflammatory gene transcription and release of cytokines, such as IL-1, IL-6, and TNF-alpha, and chemokines, thereby inducing neuroinflammation.	Reactive Oxygen Species	20-23	interleukin 1 alpha	Homo sapiens	103-107
23922312-0	2013	Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1).	Dinoprostone	186-190	interleukin 1 alpha	Homo sapiens	107-110
24079565-11	2013	Expression for the chemically activated polymethyl methacrylate resin group was significantly less for growth-regulated oncogene-alpha, interleukin-1alpha, and interleukin-3.	Polymethyl Methacrylate	40-63	interleukin 1 alpha	Homo sapiens	136-154
24079565-12	2013	Expression for the chemically activated polyethyl methacrylate resin group was significantly less for interleukin-1alpha and interleukin-3, but significantly greater for interleukin-13 and monocytes chemoattractant protein-3.	poly(ethylmethacrylate)	40-62	interleukin 1 alpha	Homo sapiens	102-120
23995233-0	2013	Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis.	Fatty Acids	0-10	interleukin 1 alpha	Homo sapiens	77-86
23995233-3	2013	We found here that atherogenesis was mediated by IL-1alpha and we identified fatty acids as potent inducers of IL-1alpha-driven vascular inflammation.	Fatty Acids	77-88	interleukin 1 alpha	Homo sapiens	111-120
23995233-4	2013	Fatty acids selectively stimulated the release of IL-1alpha but not of IL-1beta by uncoupling mitochondrial respiration.	Fatty Acids	0-11	interleukin 1 alpha	Homo sapiens	50-59
23995233-5	2013	Fatty acid-induced mitochondrial uncoupling abrogated IL-1beta secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1alpha.	Fatty Acids	0-10	interleukin 1 alpha	Homo sapiens	162-171
23995233-5	2013	Fatty acid-induced mitochondrial uncoupling abrogated IL-1beta secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1alpha.	Cholesterol	93-104	interleukin 1 alpha	Homo sapiens	162-171
23746682-1	2013	New phosphonium-based ionic liquids, denoted, 11-carboxyundecyltriphenylphosphonium bromide (IL1) and octadecyltriphenylphosphonium iodide (IL2), were employed on the sol-gel synthesis to prepare new silica-based matrices.	Phosphoranes	4-15	interleukin 1 alpha	Homo sapiens	93-96
23746682-1	2013	New phosphonium-based ionic liquids, denoted, 11-carboxyundecyltriphenylphosphonium bromide (IL1) and octadecyltriphenylphosphonium iodide (IL2), were employed on the sol-gel synthesis to prepare new silica-based matrices.	11-carboxyundecyltriphenylphosphonium bromide	46-91	interleukin 1 alpha	Homo sapiens	93-96
23746682-2	2013	The fastest gelation during the sol-gel process was observed in hydrolysis/condensation of tetraethoxysilane in the presence of IL1.	tetraethoxysilane	91-108	interleukin 1 alpha	Homo sapiens	128-131
23623504-2	2013	We investigated the effects of valproic acid (VPA) and topiramate (TPM) on the blood levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and TNF-alpha in children with idiopathic generalized and partial epilepsy.	Topiramate	67-70	interleukin 1 alpha	Homo sapiens	95-118
23965971-5	2013	Irradiated HEM cells had the greatest fold of TNFalpha secretion (UVB: 109-fold, UVA + B: 103-fold & UVB+A: 130-fold) when co-exposed to IL1alpha.	Adenosine Monophosphate	100-103	interleukin 1 alpha	Homo sapiens	141-149
23578198-2	2013	Our present study revealed that sunitinib-treated RCC cells exhibit senescence characteristics including increased SA-beta-gal activity, DcR2 and Dec1 expression, and senescence-associated secretary phenotype (SASP) such as proinflammatory cytokines interleukin (IL)-1alpha, IL-6 and IL-8 secretion.	Sunitinib	32-41	interleukin 1 alpha	Homo sapiens	250-273
23720279-2	2013	The optimized method utilizes 10 mL of water (or infusion) containing 38 muL of the IL 1-butyl-3-methylimidazolium chloride and a content of 36.1 g/L NaCl, which are mixed with Li-NTf2 (340 muL, 0.2 g/mL), followed by vortex (4 min) and centrifugation (5 min).	butyl-3-methylimidazolium chloride	89-123	interleukin 1 alpha	Homo sapiens	84-88
24152854-0	2013	Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin-1β on nitric oxide production and apoptosis in human osteoarthritic chondrocyte.	Water	8-13	interleukin 1 alpha	Homo sapiens	69-82
23574818-0	2013	Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1.	Steroids	64-71	interleukin 1 alpha	Homo sapiens	167-180
23574818-11	2013	Exogenous PGE2 inhibited IL-1 induction of NGF and this effect was mimicked when EP2 and EP4, but not EP1 and EP3, agonists were supplemented to the culture.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	25-29
23624146-5	2013	SP600125, an inhibitor of SAPK/JNK, increased the release and the mRNA expression levels of IL-6 induced by IL-1.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	108-112
23624146-7	2013	SP600125 remarkably suppressed the IL-1-induced phosphorylation of both IkappaB and NF-kappaB, whereas SP600125 failed to affect the IL-1-induced phosphorylation of AMPK, STAT3 or Src.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	35-39
23624146-9	2013	SP600125 enhanced IL-1-stimulated IL-6 release also in normal human osteoblasts.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	18-22
24152854-0	2013	Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin-1β on nitric oxide production and apoptosis in human osteoarthritic chondrocyte.	trentino	27-35	interleukin 1 alpha	Homo sapiens	69-82
24152854-0	2013	Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin-1β on nitric oxide production and apoptosis in human osteoarthritic chondrocyte.	Adenosine Monophosphate	83-86	interleukin 1 alpha	Homo sapiens	69-82
24152854-0	2013	Thermal water of Vetriolo, Trentino, inhibits the negative effect of interleukin-1β on nitric oxide production and apoptosis in human osteoarthritic chondrocyte.	Nitric Oxide	96-108	interleukin 1 alpha	Homo sapiens	69-82
23521530-6	2013	The expression of matrix metalloproteinases (MMP)-1, MMP-2, IL-1, IL-6, TNF-alpha and type 1 collagen was significantly higher in I-GMSCs than in N-GMSCs.	i-gmscs	130-137	interleukin 1 alpha	Homo sapiens	60-64
23706710-8	2013	TNFA GA and IL5 CC and TNFA GA and IL1A CC were 2 epistatic predictors of exhaled nitrogen monoxide decrease during follow-up (P = .02 and P = .004, respectively).	Nitric Oxide	82-99	interleukin 1 alpha	Homo sapiens	35-39
23746682-3	2013	The confinement of ionic liquids (especially IL1) inside the silica networks was suggested by thermogravimetric analysis and Fourier transform infrared spectroscopy.	Silicon Dioxide	61-67	interleukin 1 alpha	Homo sapiens	45-48
23658758-6	2013	However, in the presence of IL-1alpha these mediators were less secreted by OA than by normal STEs of which 15 differed significantly (p<0.01).	stes	94-98	interleukin 1 alpha	Homo sapiens	28-37
23697917-5	2013	Consequently, IL-1 blocking strategies are specific pathway targeting therapies in autoinflammatory diseases and applied in CAPS, colchicine-resistant FMF, TRAPS, HIDS and DIRA.	Colchicine	130-140	interleukin 1 alpha	Homo sapiens	14-18
24371477-9	2013	OUTCOMES: In the (+) ALA group only IL-1alpha (- 9.9% +- 3.7, P = 0.013) and IL-6 (- 26.5% +- 8.2, P = 0.003) significantly decreased during the study period.	Alanine	21-24	interleukin 1 alpha	Homo sapiens	36-45
23592003-5	2013	The frequency of the C/C genotype of IL-1alpha was 55% in CP patients, while in the control group it was 20% (p<0.0001).	Phosphorus	31-32	interleukin 1 alpha	Homo sapiens	37-46
23592003-5	2013	The frequency of the C/C genotype of IL-1alpha was 55% in CP patients, while in the control group it was 20% (p<0.0001).	Adenosine Monophosphate	112-115	interleukin 1 alpha	Homo sapiens	37-46
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Nigericin	65-74	interleukin 1 alpha	Homo sapiens	82-91
24024155-3	2013	Shifts in steady-state H2O2 concentrations (SS-[H2O2]) resulting from enforced expression of manganese superoxide dismutase (SOD2) drive IL-1alpha mRNA and protein expression.	Hydrogen Peroxide	23-27	interleukin 1 alpha	Homo sapiens	137-146
24024155-3	2013	Shifts in steady-state H2O2 concentrations (SS-[H2O2]) resulting from enforced expression of manganese superoxide dismutase (SOD2) drive IL-1alpha mRNA and protein expression.	Hydrogen Peroxide	48-52	interleukin 1 alpha	Homo sapiens	137-146
24024155-6	2013	Sub-lethal doses of H2O2 also cause IL-1alpha nuclear localization.	Hydrogen Peroxide	20-24	interleukin 1 alpha	Homo sapiens	36-45
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Nigericin	65-74	interleukin 1 alpha	Homo sapiens	164-173
23435685-3	2013	Vitamin D (vitD) and analogs have been shown to suppress TNF-alpha-induced IL-1alpha in human keratinocytes (KCs).	Vitamin D	0-9	interleukin 1 alpha	Homo sapiens	75-84
23474153-1	2013	BACKGROUND: Diacerein is a drug used in osteoarthritis (OA) that elicits an inhibitory effect on interleukin-1 and metalloproteases.	diacerein	12-21	interleukin 1 alpha	Homo sapiens	97-131
23349093-7	2013	It has been experimentally evidenced that metal particles induced higher amounts of IL-6 and IL-1 but very low amounts of TNF-alpha.	Metals	42-47	interleukin 1 alpha	Homo sapiens	93-97
23364789-4	2013	Both PRC and its targets (IL1alpha, SPRR2D, and SPRR2F) were rapidly induced by menadione, an agent that promotes apoptosis through the generation of intracellular oxidants.	Vitamin K 3	80-89	interleukin 1 alpha	Homo sapiens	26-34
23339380-10	2013	HMG supplementation was able to reduce the catabolic genes" expression in cultured HACs such as matrix metalloproteinases (MMP1 & MMP3), Interleukin 1, 6 and 8 (IL-1, IL-6 & IL-8), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Menotropins	0-3	interleukin 1 alpha	Homo sapiens	141-163
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Uric Acid	44-53	interleukin 1 alpha	Homo sapiens	82-91
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Uric Acid	44-53	interleukin 1 alpha	Homo sapiens	164-173
23379686-1	2013	The self-aggregation behavior of the double-chained ionic liquid (IL) 1,3-didecyl-2-methylimidazolium chloride ([C10C10mim]Cl) in aqueous solution has been investigated with a number of different experimental techniques.	c10c10mim	113-122	interleukin 1 alpha	Homo sapiens	52-71
23312378-5	2013	In this paper we report the use of 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide (IL1) and 1-butyl-4-methylpyridinium tetrafluoroborate (IL2) as reaction media for the derivatization of DMS with dibenzazepine.	1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide	35-98	interleukin 1 alpha	Homo sapiens	100-103
22640991-8	2013	Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0 97, 95% CI 0 95, 0 99, P= 0 03; OR 0 97, 95% CI 0 94, 0 99, P= 0 03, respectively); when adjusting for BMI, this association was lost.	Vitamin A	25-34	interleukin 1 alpha	Homo sapiens	99-103
23357557-3	2013	In human lung carcinoma A549 cells, deoxynivalenol and 3-acetyldeoxynivalenol inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-alpha more strongly than that induced by interleukin 1alpha (IL-1alpha), whereas T-2 toxin and verrucarin A exerted nonselective inhibitory effects.	deoxynivalenol	36-50	interleukin 1 alpha	Homo sapiens	205-223
23357557-3	2013	In human lung carcinoma A549 cells, deoxynivalenol and 3-acetyldeoxynivalenol inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-alpha more strongly than that induced by interleukin 1alpha (IL-1alpha), whereas T-2 toxin and verrucarin A exerted nonselective inhibitory effects.	deoxynivalenol	36-50	interleukin 1 alpha	Homo sapiens	225-234
23357557-3	2013	In human lung carcinoma A549 cells, deoxynivalenol and 3-acetyldeoxynivalenol inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-alpha more strongly than that induced by interleukin 1alpha (IL-1alpha), whereas T-2 toxin and verrucarin A exerted nonselective inhibitory effects.	3-acetyldeoxynivalenol	55-77	interleukin 1 alpha	Homo sapiens	205-223
23357557-3	2013	In human lung carcinoma A549 cells, deoxynivalenol and 3-acetyldeoxynivalenol inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-alpha more strongly than that induced by interleukin 1alpha (IL-1alpha), whereas T-2 toxin and verrucarin A exerted nonselective inhibitory effects.	3-acetyldeoxynivalenol	55-77	interleukin 1 alpha	Homo sapiens	225-234
23135821-8	2013	LP-MC displayed similar penetration-enhancing ability in vivo, and a much lower irritation potential than Triton-X100 (a moderate irritant), leading to 3-fold higher skin equivalent viability and release of 60-fold less IL-1alpha.	lp-mc	0-5	interleukin 1 alpha	Homo sapiens	220-229
23135821-8	2013	LP-MC displayed similar penetration-enhancing ability in vivo, and a much lower irritation potential than Triton-X100 (a moderate irritant), leading to 3-fold higher skin equivalent viability and release of 60-fold less IL-1alpha.	Octoxynol	106-117	interleukin 1 alpha	Homo sapiens	220-229
23348156-7	2013	For IL-1 alpha significant predictive parameters included a previous infection of hepatitis B, lower serum level of TGFbeta, age, use of alcohol, lower MELD and Chilld-Pugh scores.	Alcohols	137-144	interleukin 1 alpha	Homo sapiens	4-14
23339380-10	2013	HMG supplementation was able to reduce the catabolic genes" expression in cultured HACs such as matrix metalloproteinases (MMP1 & MMP3), Interleukin 1, 6 and 8 (IL-1, IL-6 & IL-8), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Menotropins	0-3	interleukin 1 alpha	Homo sapiens	165-169
22945591-6	2013	The inflammatory component of these immune responses is caused when urate crystals trigger both inflammasome-dependent and independent pathways to generate the proinflammatory cytokine IL-1.	Uric Acid	68-73	interleukin 1 alpha	Homo sapiens	185-189
23087373-4	2013	This effect was independent from the gene regulatory effects mediated by the broad-spectrum HDAC inhibitor trichostatin A (TSA) and thus suggests IL-1-specific functions for HDAC3.	trichostatin A	107-121	interleukin 1 alpha	Homo sapiens	146-150
23087373-4	2013	This effect was independent from the gene regulatory effects mediated by the broad-spectrum HDAC inhibitor trichostatin A (TSA) and thus suggests IL-1-specific functions for HDAC3.	trichostatin A	123-126	interleukin 1 alpha	Homo sapiens	146-150
23509928-5	2013	beta-NAD(+) inhibited the expression of MMP-1 and MMP-3 triggered by IL-1alpha at gene and protein levels.	NAD	0-11	interleukin 1 alpha	Homo sapiens	69-78
23690852-8	2013	Besides, cytotoxicity and IL-1 alpha release assays indicate that DHNA causes less irritation problems than dithranol, which is commonly employed to treat psoriasis in many countries.	1,4-dihydroxy-2-naphthoic acid	66-70	interleukin 1 alpha	Homo sapiens	26-36
23852607-1	2013	Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1alpha, and processing of IL-1beta.	Uric Acid	29-45	interleukin 1 alpha	Homo sapiens	137-146
23516523-6	2013	We found that miR-181a mimics significantly lowered IL1a expression levels in these cells and, interestingly, miR-181a inhibitors reversed this decrease.	mir-181a	14-22	interleukin 1 alpha	Homo sapiens	52-56
23744413-4	2013	Numerous studies report that treatment with clozapine (doses 37.5-600 mg) or olanzapine (doses 10-25 mg) or the use of these drugs in polytherapy cause pyrexia between 37.8-40.6  C. Additionally, levels of proinflammatory interleukins such as IL-6, IL-1,TNF-alpha were increased.	Clozapine	44-53	interleukin 1 alpha	Homo sapiens	249-253
23744413-4	2013	Numerous studies report that treatment with clozapine (doses 37.5-600 mg) or olanzapine (doses 10-25 mg) or the use of these drugs in polytherapy cause pyrexia between 37.8-40.6  C. Additionally, levels of proinflammatory interleukins such as IL-6, IL-1,TNF-alpha were increased.	Olanzapine	77-87	interleukin 1 alpha	Homo sapiens	249-253
23516523-10	2013	Interestingly, we found that miR-181a inhibited production of inflammatory factors even in IL1a-induced THP-1 cells, suggesting that the anti-inflammatory effects of miR-181a possibly involves other targets in addition to IL1a.	mir-181a	29-37	interleukin 1 alpha	Homo sapiens	91-95
23516523-10	2013	Interestingly, we found that miR-181a inhibited production of inflammatory factors even in IL1a-induced THP-1 cells, suggesting that the anti-inflammatory effects of miR-181a possibly involves other targets in addition to IL1a.	mir-181a	166-174	interleukin 1 alpha	Homo sapiens	91-95
23516523-10	2013	Interestingly, we found that miR-181a inhibited production of inflammatory factors even in IL1a-induced THP-1 cells, suggesting that the anti-inflammatory effects of miR-181a possibly involves other targets in addition to IL1a.	mir-181a	166-174	interleukin 1 alpha	Homo sapiens	222-226
23326479-8	2013	RESULTS: DON induced a pro-inflammatory response with a significant increase of expression of mRNA encoding for IL-8, IL-1alpha and IL-1beta, TNF-alpha in all used models.	deoxynivalenol	9-12	interleukin 1 alpha	Homo sapiens	118-127
23385065-3	2012	Here we demonstrate that media conditioned by cells undergoing any of the three main forms of senescence, i.e. replicative, oncogene- and drug-induced, contain high levels of IL1, IL6, and TGFb capable of inducing reactive oxygen species (ROS)-mediated DNA damage response (DDR).	Reactive Oxygen Species	214-237	interleukin 1 alpha	Homo sapiens	175-178
23385065-3	2012	Here we demonstrate that media conditioned by cells undergoing any of the three main forms of senescence, i.e. replicative, oncogene- and drug-induced, contain high levels of IL1, IL6, and TGFb capable of inducing reactive oxygen species (ROS)-mediated DNA damage response (DDR).	Reactive Oxygen Species	239-242	interleukin 1 alpha	Homo sapiens	175-178
23385065-5	2012	Whereas inhibition of IL6/STAT signaling had no effect on DDR induction in bystander cells, inhibition of either TGFbeta/SMAD or IL1/NFkappaB pathway resulted in decreased ROS production and reduced DDR in bystander cells.	Reactive Oxygen Species	172-175	interleukin 1 alpha	Homo sapiens	129-132
23522630-5	2012	Among these factors, the keratinocyte growth factor (KGF), alone or in combination with interleukin-1alpha, induces melanin deposition in vitro and hyperpigmented lesions in vivo.	Melanins	116-123	interleukin 1 alpha	Homo sapiens	88-106
22763784-7	2012	To investigate the anti-inflammatory potential of EGCG, we evaluated pro-inflammatory cytokine synthesis in IGF-I-differentiated SZ95 sebocytes and found that expression of IL-1, IL-6, and IL-8 was decreased.	epigallocatechin gallate	50-54	interleukin 1 alpha	Homo sapiens	173-177
23399841-4	2012	Suppressing ROCK with the Y27632 inhibitor suppressed IL-1-stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels.	Y 27632	26-32	interleukin 1 alpha	Homo sapiens	54-58
22930784-5	2012	OBJECTIVE: The objective of this study was to elucidate whether estrogen, tamoxifen, and/or diet modification altered IL-1 levels in normal human breast tissue.	Tamoxifen	74-83	interleukin 1 alpha	Homo sapiens	118-122
23041168-8	2012	We found that TCOH, but not TCA, increased the levels of IL-1alpha and IL-6 in a dose-dependent manner.	2,2,2-trichloroethanol	14-18	interleukin 1 alpha	Homo sapiens	57-66
23260525-5	2012	Among these factors, the keratinocyte growth factor (KGF), alone or in combination with interleukin-1alpha, induces melanin deposition in vitro and hyperpigmented lesions in vivo.	Melanins	116-123	interleukin 1 alpha	Homo sapiens	88-106
22884553-7	2012	Anti-IL-1 treatment is also effective in FMF patients resistant or partially responsive to colchicine.	Colchicine	91-101	interleukin 1 alpha	Homo sapiens	5-9
22934546-14	2012	Finally, there is a strong mechanism data that macrophage produced interleukin 1, tumor necrosis factor and interleukin 6, which are released following inflammation, causing destruction of insulin secreting islet cells and increase cortisol release, and thus have the ability to cause both type 1 and type 2 diabetes/metabolic syndrome (which resembles a Cushingoid state).	Hydrocortisone	232-240	interleukin 1 alpha	Homo sapiens	67-121
22939867-2	2012	Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA.	Fatty Acids, Omega-3	27-58	interleukin 1 alpha	Homo sapiens	166-170
23290159-6	2012	The patients displayed significantly higher Abeta1-42 and greatly lower levels of IL-1beta and TNF-alpha in the telmisartan group versus the amlodipine group (P < 0.05).	Telmisartan	112-123	interleukin 1 alpha	Homo sapiens	82-90
23290159-9	2012	CONCLUSION: Telmisartan may delay the decreased level of Abeta1-42 and reduce the levels IL-1beta and TNF-alpha in CSF so as to improve the cognitive function of elderly hypertensive patients with AD.	Telmisartan	12-23	interleukin 1 alpha	Homo sapiens	89-97
22451348-6	2012	Using this model, we assessed the effects of the inflammatory cytokine interleukin-1alpha (IL-1alpha), several bioactive sphingolipids and all-trans retinoic acid (RA) on ceramide levels in the SC.	Ceramides	171-179	interleukin 1 alpha	Homo sapiens	91-100
23202919-6	2012	Although the relationship between high inflammatory cytokine levels and low ACh levels need to be further investigated in the future, our data suggest that IL-1&amp;beta;, and cytokines induced by it, such as IL-17 and ACh, may be involved in the pathogenesis  of MS.	Adenosine Monophosphate	161-164	interleukin 1 alpha	Homo sapiens	156-160
22850568-7	2012	Further, vemurafenib reduced the expression of IL-1 protein in melanoma cell lines and most notably in human tumor biopsies from 11 of 12 melanoma patients undergoing inhibitor treatment.	Vemurafenib	9-20	interleukin 1 alpha	Homo sapiens	47-51
22451348-7	2012	Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels.	Ceramides	73-81	interleukin 1 alpha	Homo sapiens	23-32
22451348-7	2012	Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels.	Ceramides	220-228	interleukin 1 alpha	Homo sapiens	23-32
22763855-3	2012	We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs.	Dinoprostone	65-83	interleukin 1 alpha	Homo sapiens	36-49
22763855-3	2012	We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs.	Dinoprostone	65-83	interleukin 1 alpha	Homo sapiens	51-55
22763855-3	2012	We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs.	Prostaglandins E	85-88	interleukin 1 alpha	Homo sapiens	36-49
22763855-3	2012	We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs.	Prostaglandins E	85-88	interleukin 1 alpha	Homo sapiens	51-55
22763855-4	2012	The resulting PGE(2) operates in an autocrine manner, cooperating with ongoing paracrine IL-1 signaling, to induce expression of a group of cytokines by the MSCs.	Dinoprostone	14-20	interleukin 1 alpha	Homo sapiens	89-93
22481441-10	2012	Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2.	Nitric Oxide	112-124	interleukin 1 alpha	Homo sapiens	26-30
22969117-1	2012	Li and colleagues present data that cancer cell-derived interleukin-1 induces prostaglandin E(2) and cytokine secretion in mesenchymal stem cells (MSC) to activate beta-catenin signaling in the cancer cell.	Dinoprostone	78-96	interleukin 1 alpha	Homo sapiens	56-69
22481441-10	2012	Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2.	Dinoprostone	129-145	interleukin 1 alpha	Homo sapiens	26-30
22300324-7	2012	KEY RESULTS: TGF-beta (40-400 pM) reduced the maximum inhibitory effect of dexamethasone on IL-1alpha-induced IL-6 and CXCL8 production.	Dexamethasone	75-88	interleukin 1 alpha	Homo sapiens	92-101
22734707-6	2012	We have tried chemometric modeling through 2D-QSAR studies on a dataset of fifty-one compounds out of which forty-four 5-Phenylthiophenecarboxylic acid derivatives have IL-1 inhibitory activity and forty-six 5-Phenylthiophenecarboxylic acid derivatives have %AIA suppressive activity.	5-phenylthiophenecarboxylic acid	119-151	interleukin 1 alpha	Homo sapiens	169-173
22760015-3	2012	The catalyst, di-mu-chlorobis(chlorotricarbonylruthenium) [Ru(CO)(3)Cl(2)](2), and the solvent, the IL 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [BMIM][Tf(2)N], have been deposited by physical vapor deposition onto an alumina model support [Al(2)O(3)/NiAl(110)].	bis(trifluoromethylsulfonyl)azanide;3-methyl-1H-imidazol-3-ium	111-164	interleukin 1 alpha	Homo sapiens	100-104
22641358-9	2012	In conclusion, downregulation of IL-1-induced tumorigenic factors (IL-6, IL-8, VEGF, MMP-2) in U-2 OS by IL-1Ra and EGCG may positively affect tumor-associated inflammation and, as a consequence, lead to reduction in angiogenesis and invasiveness.	epigallocatechin gallate	116-120	interleukin 1 alpha	Homo sapiens	33-37
22561121-3	2012	Zaprinast was found to activate ERK1/2, p38 MAPK, JNK, NFkappaB, and PI3K/Akt, and subsequently, induce the mRNA expressions of IL-1alpha, IL-1beta, TNF-alpha, CCL2, CCL4, CXCL1, CXCL2, and CD14.	zaprinast	0-9	interleukin 1 alpha	Homo sapiens	128-137
23058021-5	2012	Silica stimulation showed a significant increase of IL-1alpha and IL-1beta in cultured medium, and an increased gene expression of CTGF in cultured fibroblasts at 1 hour, as well as an up-regulation of the COL1A2 gene at 24-hour time point.	Silicon Dioxide	0-6	interleukin 1 alpha	Homo sapiens	52-61
22101739-0	2012	Regulation of IL-1beta-induced cyclooxygenase-2 expression by interactions of Abeta peptide, apolipoprotein E and nitric oxide in human neuroglioma.	Nitric Oxide	114-126	interleukin 1 alpha	Homo sapiens	14-22
22101739-8	2012	In contrast, after co-incubation with apoE4, Abeta(1-40) increased IL-1beta-induced COX-2 expression and PGE(2) production.	Dinoprostone	105-111	interleukin 1 alpha	Homo sapiens	67-75
22101739-11	2012	Addition of Abeta(1-40) preincubated with apoE4 to H4 cells in the presence of SNAP led to an additive IL-1beta-induced COX-2 expression and PGE(2) production.	Dinoprostone	141-147	interleukin 1 alpha	Homo sapiens	103-111
22101739-13	2012	Thus a molecular understanding of the interactions of apoE4 with Abeta, NO and IL-1beta on the regulation of the COX-2/prostaglandin pathway may open new avenues in understanding the mechanism of development of neurodegenerative disease such as AD.	Prostaglandins	119-132	interleukin 1 alpha	Homo sapiens	79-87
22531705-9	2012	The elevated levels of IL-5, IL-10, IL-4, IL-23, and IL-1alpha were found to be significantly associated with exudative lesion(s) in the fluorescein angiograms.	Fluorescein	137-148	interleukin 1 alpha	Homo sapiens	53-62
22508517-5	2012	Human fibroblasts exposed to very-long-chain fatty acids exhibited increased mRNA expression of IL-1alpha and IL-1beta cytokines.	-chain fatty acids	38-56	interleukin 1 alpha	Homo sapiens	96-105
22339577-5	2012	In addition, CoQ(10)  treatment increased elastin gene expression in cultured fibroblasts and significantly decreased UVR-induced IL-1alpha production in HaCat cells.	coenzyme Q10	13-19	interleukin 1 alpha	Homo sapiens	130-139
22402362-10	2012	CONCLUSIONS: Alcohol-induced MMPs activation is a key mechanism for dysfunction of BBB via degradation of VEGFR-2 protein and activation of caspase-1 or IL-1beta release.	Alcohols	13-20	interleukin 1 alpha	Homo sapiens	153-161
22434859-2	2012	Compound IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages.	11H-indeno(1,2-b)quinoxalin-11-one oxime	15-55	interleukin 1 alpha	Homo sapiens	136-159
22745145-9	2012	CONCLUSION: short-term oral NAC treatment resulted in reduction of circulating PCT, IL-6, IL-1, C3, sICAM, hsCRP, and TNF- in CAPD patients.	Acetylcysteine	28-31	interleukin 1 alpha	Homo sapiens	90-94
22034068-12	2012	Rapamycin also protected against cell death induced by sodium nitroprusside and TNFalpha plus actinomycin D and prevented sGAG loss induced by IL-1alpha.	Sirolimus	0-9	interleukin 1 alpha	Homo sapiens	143-152
22444631-5	2012	Calcium influx induced by the opening of cation channels was sufficient for the inflammasome-independent IL-1alpha secretion.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	105-114
22242698-8	2012	In stark contrast to the untreated fibroblasts, significant calcium signaling in response to capsaicin and resiniferatoxin in HPBFs treated for 24 and 48 hours with TNF-alpha, LPS, or IL-1alpha was also observed.	Calcium	60-67	interleukin 1 alpha	Homo sapiens	184-193
22242698-8	2012	In stark contrast to the untreated fibroblasts, significant calcium signaling in response to capsaicin and resiniferatoxin in HPBFs treated for 24 and 48 hours with TNF-alpha, LPS, or IL-1alpha was also observed.	Capsaicin	93-102	interleukin 1 alpha	Homo sapiens	184-193
22242698-8	2012	In stark contrast to the untreated fibroblasts, significant calcium signaling in response to capsaicin and resiniferatoxin in HPBFs treated for 24 and 48 hours with TNF-alpha, LPS, or IL-1alpha was also observed.	resiniferatoxin	107-122	interleukin 1 alpha	Homo sapiens	184-193
22171990-0	2012	mTHPC-mediated photodynamic treatment up-regulates the cytokines VEGF and IL-1alpha.	temoporfin	0-5	interleukin 1 alpha	Homo sapiens	74-83
22089456-5	2012	RESULTS: GS treatment at 1 and 2 mM significantly inhibited (p &lt;= 0.03) production of endogenous and IL-1ss-induced PGE(2).	Prostaglandins E	119-122	interleukin 1 alpha	Homo sapiens	104-108
22171990-3	2012	Here, we studied the expression of cytokines vascular endothelial growth factor (VEGF) and interleukin-1alpha (IL-1alpha) in the human epidermoid carcinoma A-431 cells following m-tetra(3-hydroxyphenyl)-chlorin (mTHPC)-mediated PDT in vitro and assessed the IL-1alpha effect on VEGF expression.	tetra(3-hydroxyphenyl)-chlorin	180-210	interleukin 1 alpha	Homo sapiens	91-109
22171990-3	2012	Here, we studied the expression of cytokines vascular endothelial growth factor (VEGF) and interleukin-1alpha (IL-1alpha) in the human epidermoid carcinoma A-431 cells following m-tetra(3-hydroxyphenyl)-chlorin (mTHPC)-mediated PDT in vitro and assessed the IL-1alpha effect on VEGF expression.	tetra(3-hydroxyphenyl)-chlorin	180-210	interleukin 1 alpha	Homo sapiens	111-120
22171990-3	2012	Here, we studied the expression of cytokines vascular endothelial growth factor (VEGF) and interleukin-1alpha (IL-1alpha) in the human epidermoid carcinoma A-431 cells following m-tetra(3-hydroxyphenyl)-chlorin (mTHPC)-mediated PDT in vitro and assessed the IL-1alpha effect on VEGF expression.	temoporfin	212-217	interleukin 1 alpha	Homo sapiens	111-120
22171990-4	2012	Quantitative polymerase chain reaction and enzyme-linked immunosorbent assay revealed the enhanced production of VEGF and IL-1alpha both on mRNA and protein levels by mTHPC-loaded cells after light exposure.	temoporfin	167-172	interleukin 1 alpha	Homo sapiens	122-131
22171990-7	2012	Thus, in addition to the cytotoxic action on the A-431 cells, mTHPC-mediated PDT stimulated the production of VEGF and IL-1alpha, and IL-1alpha contributed to the VEGF overexpression.	temoporfin	62-67	interleukin 1 alpha	Homo sapiens	119-128
22178533-14	2012	Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype.	Arsenic	114-121	interleukin 1 alpha	Homo sapiens	70-89
22178533-14	2012	Subsequent pathway analysis further revealed a gene network involving interleukin 1-alpha (IL1A) in mediating the arsenic-resistant phenotype.	Arsenic	114-121	interleukin 1 alpha	Homo sapiens	91-95
21809384-6	2012	Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment.	Guanosine Triphosphate	64-67	interleukin 1 alpha	Homo sapiens	18-27
21922187-0	2012	Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-alpha), disease activity and response criteria.	Fatty Acids, Omega-3	0-19	interleukin 1 alpha	Homo sapiens	75-79
22224906-2	2012	We show here that mixtures of the IL 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 2,2,2-trifluoroethanol (TFE) display the intriguing phenomenon of hyperpolarity, examples of which are notably sparse in the literature.	1-butyl-3-methylimidazolium hexafluorophosphate	86-97	interleukin 1 alpha	Homo sapiens	34-38
22224906-2	2012	We show here that mixtures of the IL 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 2,2,2-trifluoroethanol (TFE) display the intriguing phenomenon of hyperpolarity, examples of which are notably sparse in the literature.	Trifluoroethanol	103-125	interleukin 1 alpha	Homo sapiens	34-38
22224906-2	2012	We show here that mixtures of the IL 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 2,2,2-trifluoroethanol (TFE) display the intriguing phenomenon of hyperpolarity, examples of which are notably sparse in the literature.	Trifluoroethanol	127-130	interleukin 1 alpha	Homo sapiens	34-38
22141451-9	2012	Both DNCB and BKC increased the secretion of IL-1alpha from HaCaT cells; however, ROS production as well as other changes, except DNCB-induced secretion of IL-1alpha, was not inhibited by antioxidants.	Dinitrochlorobenzene	5-9	interleukin 1 alpha	Homo sapiens	45-54
22141451-9	2012	Both DNCB and BKC increased the secretion of IL-1alpha from HaCaT cells; however, ROS production as well as other changes, except DNCB-induced secretion of IL-1alpha, was not inhibited by antioxidants.	Benzalkonium Compounds	14-17	interleukin 1 alpha	Homo sapiens	45-54
22141451-9	2012	Both DNCB and BKC increased the secretion of IL-1alpha from HaCaT cells; however, ROS production as well as other changes, except DNCB-induced secretion of IL-1alpha, was not inhibited by antioxidants.	Dinitrochlorobenzene	130-134	interleukin 1 alpha	Homo sapiens	156-165
22209282-7	2012	RESULTS: Compared to vehicle, topical cholesterol significantly decreased the degree of dermal inflammatory infiltrates and exocytosis, and also decreased the expression of MMP-1, IL-6, and IL-1ss mRNA.	Cholesterol	38-49	interleukin 1 alpha	Homo sapiens	190-194
21809384-6	2012	Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment.	Cytochalasin D	128-142	interleukin 1 alpha	Homo sapiens	18-27
23383400-4	2012	At baseline, PBMCs of four sALS patients (Group 1) showed significantly increased expression of TLR2 and CD14; ALOX5, PTGS2 and MMP1; IL1alpha, IL1beta, IL6, IL36G, IL8 and TNF; CCL3, CCL20, CXCL2, CXCL3 and CXCL5.	sals	27-31	interleukin 1 alpha	Homo sapiens	134-142
22903670-3	2012	Both naturally occurring and disease-associated autoantibodies against a variety of cytokines have been reported, including NAbs against interleukin (IL)-1alpha, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon (IFN)-alpha, IFN-beta, IFN-gamma, macrophage chemotactic protein-1 and IL-21.	nabs	124-128	interleukin 1 alpha	Homo sapiens	137-160
21399480-5	2012	Risk may be enhanced by neuroleptics (up-regulate TF), haloperidol (up-regulates IL1B and PION), olanzapine (down-regulates THRA and PRNP, up-regulates IL1A), and chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).	Olanzapine	97-107	interleukin 1 alpha	Homo sapiens	152-156
22153345-3	2012	Our present study reveals that eudesmane-type alpha-methylene gamma-lactones and alpha-bromo ketones inhibit multiple steps in the NF-kappaB signaling pathway induced by IL-1alpha and TNF-alpha.	alpha-bromo ketones	81-100	interleukin 1 alpha	Homo sapiens	170-179
22891999-4	2012	Human OA cartilage was incubated in ex-vivo conditions to examine spontaneous or IL-1 induced production of eicosanoids in the presence of various COX inhibitors.	Eicosanoids	108-119	interleukin 1 alpha	Homo sapiens	81-85
22891999-9	2012	IL-1 treatment further enhanced these eicosanoids production.	Eicosanoids	38-49	interleukin 1 alpha	Homo sapiens	0-4
22449139-9	2012	It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells.	2-ethyl-3,5-dimethylpyrazine	81-84	interleukin 1 alpha	Homo sapiens	108-117
22449139-9	2012	It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells.	2-ethyl-3,5-dimethylpyrazine	81-84	interleukin 1 alpha	Homo sapiens	214-223
22186417-9	2012	Cotreatment with LPS and sodium propionate decreased LPS-induced expression of inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1alpha, intercellular adhesion molecule-1, and platelet endothelial cell adhesion molecule-1 but not IL-1beta or lymphocyte function-associated antigen-1.	sodium propionate	25-42	interleukin 1 alpha	Homo sapiens	138-147
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	Disaccharides	34-47	interleukin 1 alpha	Homo sapiens	146-155
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	6-o	80-83	interleukin 1 alpha	Homo sapiens	146-155
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	Glucosamine	93-104	interleukin 1 alpha	Homo sapiens	146-155
22087636-0	2012	Six alkaloids inhibit secretion of IL-1alpha, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.	Alkaloids	4-13	interleukin 1 alpha	Homo sapiens	35-44
22087636-4	2012	The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB(2); Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin.	sinomenine	26-36	interleukin 1 alpha	Homo sapiens	93-102
22087636-4	2012	The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB(2); Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin.	oxymartrine	38-49	interleukin 1 alpha	Homo sapiens	93-102
22087636-4	2012	The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB(2); Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin.	evodiamine	54-64	interleukin 1 alpha	Homo sapiens	93-102
22267087-6	2012	This finding, together with our previous data on IL-1Ra indicate that important members of the IL-1 family are significantly altered during the LCAP treatment of patients with IBD.	PERACETIC ACID	144-148	interleukin 1 alpha	Homo sapiens	49-53
22267087-7	2012	Since IL-1 and its antagonists are important for regulation of inflammatory processes in IBD, we speculate that the LCAP related changes in sIL-1RI and IL-1Ra might impact the clinical outcome.	PERACETIC ACID	116-120	interleukin 1 alpha	Homo sapiens	6-10
22102722-3	2012	In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6.	Uric Acid	29-32	interleukin 1 alpha	Homo sapiens	124-133
22102722-5	2012	Both P2Y(6)-specific antagonist and P2Y(6) antisense oligonucleotides significantly inhibited the production of IL-1alpha, IL-8/CXCL8, and IL-6 by NHK.	Oligonucleotides	53-69	interleukin 1 alpha	Homo sapiens	112-121
22605923-6	2012	Pretreatment with 10(-10) M 17-beta-estradiol greatly inhibited the increased expression and production of IL-6, IL-1, and TNF-alpha induced by hyperosmolarity, whereas with the administration of SB203580 (10 muM), an inhibitor of the p38 pathway, the inhibiting effect of 17-beta-estradiol disappeared.	Estradiol	28-45	interleukin 1 alpha	Homo sapiens	113-117
22605923-8	2012	CONCLUSIONS: 17-beta-estradiol greatly inhibited the expression and production of proinflammatory cytokines IL-6, IL-1, and TNF-alpha, which were stimulated by hyperosmolarity in SV40-immortalized hCECs.	Estradiol	13-30	interleukin 1 alpha	Homo sapiens	114-118
22166436-5	2012	Activation of the NF-kappaB death pathway has been shown to occur following microglial activation related release of Cox-2, IL-1beta, and Toll-like receptor activation, resulting in increased degeneration of DA neurons of the SNpc.	Dopamine	208-210	interleukin 1 alpha	Homo sapiens	124-132
23144702-11	2012	It identifies two X-linked genes associated with altered risk of severe malaria in females, identifies mutations in ADCY9, IL1A and CD40L as being associated with altered risk of severe respiratory distress and acidosis, both of which are characterised by high serum lactate levels, and also identifies novel genetic associations with severe malaria (TRIM5) and cerebral malaria(IL-13 and RTN3).	Lactic Acid	267-274	interleukin 1 alpha	Homo sapiens	123-127
21818627-7	2012	Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines.	leupeptin	162-171	interleukin 1 alpha	Homo sapiens	48-57
21818627-7	2012	Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines.	leupeptin	162-171	interleukin 1 alpha	Homo sapiens	235-244
22153345-3	2012	Our present study reveals that eudesmane-type alpha-methylene gamma-lactones and alpha-bromo ketones inhibit multiple steps in the NF-kappaB signaling pathway induced by IL-1alpha and TNF-alpha.	eudesmane	31-40	interleukin 1 alpha	Homo sapiens	170-179
22153345-3	2012	Our present study reveals that eudesmane-type alpha-methylene gamma-lactones and alpha-bromo ketones inhibit multiple steps in the NF-kappaB signaling pathway induced by IL-1alpha and TNF-alpha.	alpha-methylene gamma-lactones	46-76	interleukin 1 alpha	Homo sapiens	170-179
22675954-6	2012	The increase in IL-8 production by IL-1alpha or TNF-alpha was further enhanced by simultaneous addition of C2-ceramide.	N-acetylsphingosine	107-118	interleukin 1 alpha	Homo sapiens	35-44
22675954-7	2012	The increase of IL-8 stimulated by IL-1alpha or TNF-alpha was also suppressed by treatment with U0126 or SB203580.	U 0126	96-101	interleukin 1 alpha	Homo sapiens	35-44
22675954-7	2012	The increase of IL-8 stimulated by IL-1alpha or TNF-alpha was also suppressed by treatment with U0126 or SB203580.	SB 203580	105-113	interleukin 1 alpha	Homo sapiens	35-44
22675954-8	2012	The results of this study demonstrate that the production of IL-8 induced by IL-1alpha and TNF-alpha is enhanced by C2-ceramide, and suppressed by MEK inhibitor or P38 MAP kinase inhibitor.	N-acetylsphingosine	116-127	interleukin 1 alpha	Homo sapiens	77-86
23055659-9	2012	Interleukin-1alpha release was greater than that for the negative control (&gt;20 pg/mL) and the positive control (BAK 0.01%), Nyogel, and Timoptol treatments and not different after treatment with Timolabak and Timogel.	Benzalkonium Compounds	115-118	interleukin 1 alpha	Homo sapiens	0-18
23055659-9	2012	Interleukin-1alpha release was greater than that for the negative control (&gt;20 pg/mL) and the positive control (BAK 0.01%), Nyogel, and Timoptol treatments and not different after treatment with Timolabak and Timogel.	nyogel	127-133	interleukin 1 alpha	Homo sapiens	0-18
23055659-9	2012	Interleukin-1alpha release was greater than that for the negative control (&gt;20 pg/mL) and the positive control (BAK 0.01%), Nyogel, and Timoptol treatments and not different after treatment with Timolabak and Timogel.	Timolol	139-147	interleukin 1 alpha	Homo sapiens	0-18
23055659-9	2012	Interleukin-1alpha release was greater than that for the negative control (&gt;20 pg/mL) and the positive control (BAK 0.01%), Nyogel, and Timoptol treatments and not different after treatment with Timolabak and Timogel.	timogel	212-219	interleukin 1 alpha	Homo sapiens	0-18
22087636-4	2012	The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB(2); Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin.	stachydrine	104-115	interleukin 1 alpha	Homo sapiens	93-102
22253903-16	2012	Although not supported by the primary endpoint, this may indicate that IL-1 inhibition influences fatigue in patients with pSS.	pss	123-126	interleukin 1 alpha	Homo sapiens	71-75
22384041-0	2012	Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.	Threonine	112-121	interleukin 1 alpha	Homo sapiens	0-13
22832503-7	2012	The significant positive correlations between neopterin and either IL-1 or TNF-alpha were significantly greater in depression than in ME/CFS.	Neopterin	46-55	interleukin 1 alpha	Homo sapiens	67-71
21996445-9	2011	DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression.	Nickel	12-18	interleukin 1 alpha	Homo sapiens	126-131
21835205-7	2011	PGE(2) alone showed slight effect on IL-1, IL-18, and IL-33 mRNA expression in DCs.	Prostaglandins E	0-3	interleukin 1 alpha	Homo sapiens	37-41
21996445-9	2011	DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression.	Chromium	36-38	interleukin 1 alpha	Homo sapiens	126-131
21878375-5	2011	DMSO at 0.5% decreased significantly mRNA levels of 14 proteins involved in the inflammatory response (including IL-6, IL-1alpha, IL-1beta, and COX-2).	Dimethyl Sulfoxide	0-4	interleukin 1 alpha	Homo sapiens	119-128
22042237-6	2011	Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-kappaB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein.	Chondroitin Sulfates	70-72	interleukin 1 alpha	Homo sapiens	241-245
21787753-0	2011	EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	19-23
21787753-4	2011	Because IL-1 plays a crucial role in inflammation-associated carcinogenesis, we analyzed the biological effects of IL-1 and its modulation by the chemopreventive green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in the human pancreatic adenocarcinoma cell line Colo357.	Polyphenols	172-182	interleukin 1 alpha	Homo sapiens	115-119
21787753-6	2011	IL-1 responsiveness and constitutive MMP-2 release in Colo357 were downregulated by EGCG in a dose- and time-dependent manner.	epigallocatechin gallate	84-88	interleukin 1 alpha	Homo sapiens	0-4
21787753-8	2011	Since EGCG effects on cytokine production precede reduction in cell viability, we hypothesize that these findings are not only a result of cell death but also depend on alterations in the IL-1 signaling cascade.	epigallocatechin gallate	6-10	interleukin 1 alpha	Homo sapiens	188-192
21170958-5	2011	Here, we provide evidence that increased MMP-3 expression by 5-aza-dC is modulated by interleukin-1 (IL-1).	Decitabine	61-69	interleukin 1 alpha	Homo sapiens	86-99
21170958-5	2011	Here, we provide evidence that increased MMP-3 expression by 5-aza-dC is modulated by interleukin-1 (IL-1).	Decitabine	61-69	interleukin 1 alpha	Homo sapiens	101-105
21796149-3	2011	beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs.	beta-Glucans	0-11	interleukin 1 alpha	Homo sapiens	64-73
21796149-4	2011	Well-differentiated NHEKs produced elevated IL-8 levels, whereas ATP, a danger signal, significantly increased IL-8 and IL-6 production, and the pathogen-associated compound, poly(I:C), augmented IL-1alpha production by beta-glucan-stimulated NHEKs.	beta-Glucans	220-231	interleukin 1 alpha	Homo sapiens	196-205
22058415-0	2011	Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.	Uric Acid	0-9	interleukin 1 alpha	Homo sapiens	68-72
21954434-7	2011	We identified for the first time several important downstream signaling pathways affected by endogenous IL-1, including reactive oxygen and nitrogen species, COX-2, and phosphorylated NF-kappaB inhibitor (IkappaB) and stress-activated protein kinase/c-jun-NH(2)-kinase; all of which were decreased by siRNA to IL-1s.	reactive oxygen and nitrogen species	120-156	interleukin 1 alpha	Homo sapiens	104-108
21663740-2	2011	In human lung carcinoma A549 cells, cytotrienin A was found to inhibit more strongly the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor (TNF)-alpha than the expression induced by interleukin (IL)-1alpha.	cytotrienin A	36-49	interleukin 1 alpha	Homo sapiens	235-258
21447989-0	2011	Diabetic Retinopathy Is Associated with Decreased Tyrosine Nitrosylation of Vitreous Interleukins IL-1alpha, IL-1beta, and IL-7.	Tyrosine	50-58	interleukin 1 alpha	Homo sapiens	98-107
21447989-6	2011	RESULTS: Diabetes was associated with decreased tyrosine nitrosylation of IL-1alpha, IL-1beta and IL-7 and an increased tyrosine phosphorylation/nitrosylation ratio with respect to controls in IL-1alpha (1.58+-0.22 vs. 2.74+-0.39, respectively; p&lt;0.05) and IL-7 (2.15+-0.01 vs. 3.26+-0.57, respectively; p&lt;0.05).	Tyrosine	48-56	interleukin 1 alpha	Homo sapiens	74-83
21277619-10	2011	The reasons for using interleukin-1 targeting drugs in FMF patients were as follows: (1) incomplete control of disease activity despite colchicine treatment; (2) high serum amyloid A levels despite colchicine treatment; (3) impossibility to use colchicine treatment because of severe side effects; (4) FMF in association with vasculitis.	Colchicine	136-146	interleukin 1 alpha	Homo sapiens	22-35
21277619-10	2011	The reasons for using interleukin-1 targeting drugs in FMF patients were as follows: (1) incomplete control of disease activity despite colchicine treatment; (2) high serum amyloid A levels despite colchicine treatment; (3) impossibility to use colchicine treatment because of severe side effects; (4) FMF in association with vasculitis.	Colchicine	198-208	interleukin 1 alpha	Homo sapiens	22-35
21277619-10	2011	The reasons for using interleukin-1 targeting drugs in FMF patients were as follows: (1) incomplete control of disease activity despite colchicine treatment; (2) high serum amyloid A levels despite colchicine treatment; (3) impossibility to use colchicine treatment because of severe side effects; (4) FMF in association with vasculitis.	Colchicine	198-208	interleukin 1 alpha	Homo sapiens	22-35
21277619-11	2011	CONCLUSIONS: Interleukin-1 targeting drugs may be good candidates when looking for an alternative or supplementary treatment to colchicine.	Colchicine	128-138	interleukin 1 alpha	Homo sapiens	13-26
21663740-6	2011	In the presence of both U0126 and SB203580, cytotrienin A inhibited TNF-alpha- and IL-1alpha-induced ICAM-1 expression at almost equivalent concentrations.	SB 203580	34-42	interleukin 1 alpha	Homo sapiens	83-92
21663740-6	2011	In the presence of both U0126 and SB203580, cytotrienin A inhibited TNF-alpha- and IL-1alpha-induced ICAM-1 expression at almost equivalent concentrations.	cytotrienin A	44-57	interleukin 1 alpha	Homo sapiens	83-92
21663740-6	2011	In the presence of both U0126 and SB203580, cytotrienin A inhibited TNF-alpha- and IL-1alpha-induced ICAM-1 expression at almost equivalent concentrations.	U 0126	24-29	interleukin 1 alpha	Homo sapiens	83-92
21750200-11	2011	In the DEN-induced model, IL-1alpha was highly expressed in sprouting tumors and gradually decreased in conjunction with HCC development.	Diethylnitrosamine	7-10	interleukin 1 alpha	Homo sapiens	26-35
21333270-7	2011	In vitro results also suggested that stimulation of Tca-8113 cells with TLR-9 agonist CpG-ODN could significantly increase tumour cell proliferation as well as subsequent IL-1alpha and IL-6 secretions (P&lt;0.01), which could be partially inhibited by usage of anti-TLR-9 protein.	Trichloroacetic Acid	52-55	interleukin 1 alpha	Homo sapiens	171-180
21873959-4	2011	Pro-inflammatory cytokines, such as TNF-alpha, IL-1 and IL-6, stimulate central serotonin (5-HT) neurotransmission and are over-expressed in depression, which has been linked with hypothalamic-pituitary-adrenal axis (HPA) hyperactivity.	Serotonin	80-89	interleukin 1 alpha	Homo sapiens	47-51
21653679-0	2011	Interleukin-1alpha mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells.	Calcitriol	61-85	interleukin 1 alpha	Homo sapiens	0-18
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Hydrocortisone	38-46	interleukin 1 alpha	Homo sapiens	5-14
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Androstenedione	48-63	interleukin 1 alpha	Homo sapiens	5-14
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone	65-87	interleukin 1 alpha	Homo sapiens	5-14
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone Sulfate	92-122	interleukin 1 alpha	Homo sapiens	5-14
21316034-2	2011	Epidermal keratinocyte expression of many AMPs increases in response to interleukin-1alpha (IL-1alpha).	Adenylyl sulfate	42-46	interleukin 1 alpha	Homo sapiens	72-90
21316034-2	2011	Epidermal keratinocyte expression of many AMPs increases in response to interleukin-1alpha (IL-1alpha).	Adenylyl sulfate	42-46	interleukin 1 alpha	Homo sapiens	92-101
21316034-4	2011	To better understand innate immunity in the oral cavity, we sought to determine how IL-1alpha might regulate expression of AMPs by human gingival keratinocytes (HGKs) using DNA microarray and Western blot analyses.	Adenylyl sulfate	123-127	interleukin 1 alpha	Homo sapiens	84-93
21316034-6	2011	Of the expressed AMPs, S100A7, S100A12 and LCN2 were up-regulated by IL-1alpha (inducible AMPs); the other AMPs were considered to be constitutive.	Adenylyl sulfate	17-21	interleukin 1 alpha	Homo sapiens	69-78
21316034-6	2011	Of the expressed AMPs, S100A7, S100A12 and LCN2 were up-regulated by IL-1alpha (inducible AMPs); the other AMPs were considered to be constitutive.	Adenylyl sulfate	90-94	interleukin 1 alpha	Homo sapiens	69-78
21316034-6	2011	Of the expressed AMPs, S100A7, S100A12 and LCN2 were up-regulated by IL-1alpha (inducible AMPs); the other AMPs were considered to be constitutive.	Adenylyl sulfate	90-94	interleukin 1 alpha	Homo sapiens	69-78
21316034-7	2011	Human gingival keratinocytes, therefore, express constitutive and IL-1alpha-inducible AMPs to provide a rapid and robust innate response to microbial infection.	Adenylyl sulfate	86-90	interleukin 1 alpha	Homo sapiens	66-75
21653679-4	2011	Interestingly, one of the most highly upregulated genes by vitamin D(3) was the proinflammatory cytokine interleukin-1alpha (IL-1alpha).	Vitamin D	59-68	interleukin 1 alpha	Homo sapiens	105-123
21653679-4	2011	Interestingly, one of the most highly upregulated genes by vitamin D(3) was the proinflammatory cytokine interleukin-1alpha (IL-1alpha).	Vitamin D	59-68	interleukin 1 alpha	Homo sapiens	125-134
21653679-5	2011	Systems biology analyses supported a central role for IL-1alpha in the vitamin D(3) response in PrP/SCs.	Vitamin D	71-80	interleukin 1 alpha	Homo sapiens	54-63
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	48-57	interleukin 1 alpha	Homo sapiens	28-37
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	166-175	interleukin 1 alpha	Homo sapiens	28-37
21653679-6	2011	siRNA-mediated knockdown of IL-1alpha abrogated vitamin D(3)-induced growth suppression, establishing a requirement for IL-1alpha in the antiproliferative effects of vitamin D(3) in PrP/SCs.	Vitamin D	166-175	interleukin 1 alpha	Homo sapiens	120-129
21653679-7	2011	These studies establish a system to study the molecular profile of PrP/SC differentiation, proliferation, and senescence, and they point to an important new role for IL-1alpha in vitamin D(3) signaling in PrP/SCs.	Vitamin D	179-188	interleukin 1 alpha	Homo sapiens	166-175
21847358-4	2011	The coculture of PDAC and CAF cell lines enhanced the levels of inflammatory factors including IL-1alpha, IL-6, CXCL8, VEGF-A, CCL20, and COX-2.	pdac	17-21	interleukin 1 alpha	Homo sapiens	95-104
21546167-5	2011	In addition, nicotine or its metabolites can result in decrease of pro-inflammatory cytokines like tumor necrosis factor-alpha, interleukins 1 and 6, and increase of anti-inflammatory cytokine interleukin-10.	Nicotine	13-21	interleukin 1 alpha	Homo sapiens	67-148
21804080-5	2011	Interferon-gamma and interleukin-1alpha, but not interferon-alpha, treatment of cultured dermal fibroblasts induced mRNA expression of CHST-11, which attaches sulfates to the 4-position of unsulfated chondroitin.	Sulfates	159-167	interleukin 1 alpha	Homo sapiens	21-39
21804080-5	2011	Interferon-gamma and interleukin-1alpha, but not interferon-alpha, treatment of cultured dermal fibroblasts induced mRNA expression of CHST-11, which attaches sulfates to the 4-position of unsulfated chondroitin.	Chondroitin	200-211	interleukin 1 alpha	Homo sapiens	21-39
21518761-9	2011	Our findings show that the presence of IL-1 and/or IL-6 during activation of human CD8 T cells attenuates Fas-mediated AICD, whereas IL-12 increases the susceptibility of activated CD8 T cells to this form of cell death.	ammonium ferrous sulfate	106-109	interleukin 1 alpha	Homo sapiens	39-43
21145553-3	2011	The IL 1-hexyl-3-methylimidazolium hexafluorophosphate ([HMIm][PF(6)]) and methanol (MeOH) were used as extraction and dispersion solvent, respectively, for the DLLME procedure.	[hmim][pf(6)]	56-69	interleukin 1 alpha	Homo sapiens	4-8
21787008-1	2011	In this paper, the nanostructural organization and subpicosecond intermolecular dynamics in the mixtures of CS(2) and the room temperature ionic liquid (IL) 1-pentyl-3-methylimidazolium bis{(trifluoromethane)sulfonyl}amide ([C(5)mim][NTf(2)]) were studied as a function of concentration using molecular dynamics (MD) simulations and optical heterodyne-detected Raman-induced Kerr effect spectroscopy.	Cesium	108-110	interleukin 1 alpha	Homo sapiens	139-158
21787008-1	2011	In this paper, the nanostructural organization and subpicosecond intermolecular dynamics in the mixtures of CS(2) and the room temperature ionic liquid (IL) 1-pentyl-3-methylimidazolium bis{(trifluoromethane)sulfonyl}amide ([C(5)mim][NTf(2)]) were studied as a function of concentration using molecular dynamics (MD) simulations and optical heterodyne-detected Raman-induced Kerr effect spectroscopy.	[c(5)mim][ntf	224-237	interleukin 1 alpha	Homo sapiens	139-158
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 alpha	Homo sapiens	65-69
21682897-16	2011	In addition, the COX-2 product 15DeltaPGJ(2) added to the cells: 1) strongly represses IL-6 and IL-8 induced by IL-1alpha; 2) represses mPGES expression induced by IL-1alpha and the synthesis of PGE(2).	Prostaglandins E	137-140	interleukin 1 alpha	Homo sapiens	112-121
21682897-16	2011	In addition, the COX-2 product 15DeltaPGJ(2) added to the cells: 1) strongly represses IL-6 and IL-8 induced by IL-1alpha; 2) represses mPGES expression induced by IL-1alpha and the synthesis of PGE(2).	Prostaglandins E	137-140	interleukin 1 alpha	Homo sapiens	164-173
21402483-9	2011	Changes in serum indicators in beta-TI patients were associated with altered expressions in PBMCs of hepcidin and IL-1alpha, involved in some way in the regulation of iron homeostasis.	Iron	167-171	interleukin 1 alpha	Homo sapiens	114-123
20595464-10	2011	Pretreatment of hASM cells with HAGG significantly inhibited IL-1alpha- and basic fibroblast growth factor-induced extracellular signal-regulated kinase 1/2 and p38(MAPK) phosphorylation.	hagg	32-36	interleukin 1 alpha	Homo sapiens	61-70
21448188-4	2011	Among translation inhibitors tested, acetoxycycloheximide and anisomycin, but neither puromycin nor emetine, inhibited the TNF-alpha-induced ICAM-1 expression at lower concentrations than the IL-1alpha-induced ICAM-1 expression.	Anisomycin	62-72	interleukin 1 alpha	Homo sapiens	192-201
21712624-13	2011	Post-hoc t-tests confirmed lower levels of AL in IL-1A/B-variant Down subjects (P &lt; 0.05).	Aluminum	43-45	interleukin 1 alpha	Homo sapiens	49-54
21191074-0	2011	IL-1alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.	Mineral Oil	78-93	interleukin 1 alpha	Homo sapiens	0-9
21243457-4	2011	This fact, associated with novel insights into the molecular mechanisms activated by the urate crystal deposition, is at the basis of new therapeutics under clinical development for gout, a valid example being the effective targeting of the proinflammatory cytokine interleukin-1.	Uric Acid	89-94	interleukin 1 alpha	Homo sapiens	266-279
21159830-3	2011	We report the effect of anti-tumor necrosis factor therapy (etanercept) and anti-interleukin 1 (IL-1) treatment (anakinra) in 6 cases resistant to colchicine therapy.	Colchicine	147-157	interleukin 1 alpha	Homo sapiens	76-100
21191074-4	2011	In this study, we reveal the essential role of IL-1alpha in sustaining the chronic recruitment of neutrophils following 2,6,10,14 tetramethylpentadecane treatment.	pristane	120-152	interleukin 1 alpha	Homo sapiens	47-56
21191074-8	2011	Taken together, our findings uncover an IL-1alpha-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation.	Hydrocarbons	99-110	interleukin 1 alpha	Homo sapiens	40-49
21083841-5	2011	MATERIAL &amp; METHODS: IL1-Rs expression was analyzed at the levels of the protein and mRNA using immunofluorescent and real-time polymerase chain reaction methods, respectively.	Adenosine Monophosphate	10-13	interleukin 1 alpha	Homo sapiens	24-27
20840666-7	2011	Importantly, administration of D2C significantly prolonged survival time of nude mice transplanted with human PBMCs when compared with that of control IgG-treated animals (61.2 +- 4.46 vs. 22.1 +- 5.5 days), which is associated with inhibited GVHR characterized by decreased interleukin-1 and tumor necrosis factor alpha production derived from transplanted PBMCs.	d2c	31-34	interleukin 1 alpha	Homo sapiens	275-320
21233852-4	2011	Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support this notion and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.	Glucose	222-229	interleukin 1 alpha	Homo sapiens	62-75
20937349-7	2011	When compared to untreated controls, two irritating ingredients, nonoxynol 9 and benzalkonium chloride, reduced tissue viability to &lt;40% and TEER to &lt;60% while increasing NaFl leakage by 11-24% and IL-1alpha and IL-1beta release by &gt;100%.	Nonoxynol	65-74	interleukin 1 alpha	Homo sapiens	204-213
20937349-7	2011	When compared to untreated controls, two irritating ingredients, nonoxynol 9 and benzalkonium chloride, reduced tissue viability to &lt;40% and TEER to &lt;60% while increasing NaFl leakage by 11-24% and IL-1alpha and IL-1beta release by &gt;100%.	Benzalkonium Compounds	81-102	interleukin 1 alpha	Homo sapiens	204-213
22856153-4	2011	High clinicoimmunological efficacy of the complex therapy with cycloferon as an immunomodulator providing more balanced production of pro- and anti-inflammatory cytokines (IL-1alpha, INF-gamma and IL-10) was shown.	10-carboxymethyl-9-acridanone	63-73	interleukin 1 alpha	Homo sapiens	172-181
20934487-3	2011	Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1beta), and this up-regulation was quenched using specific NF-kB inhibitors including curcumin.	Curcumin	261-269	interleukin 1 alpha	Homo sapiens	172-180
21092940-2	2011	CoSO(4) in an ionic liquid, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1), was found to be an efficient catalyst for the hydrolysis of cellulose at 150 C, which led to 84% conversion of MCC after 300min reaction time.	cobalt sulfate	0-7	interleukin 1 alpha	Homo sapiens	92-96
21092940-2	2011	CoSO(4) in an ionic liquid, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1), was found to be an efficient catalyst for the hydrolysis of cellulose at 150 C, which led to 84% conversion of MCC after 300min reaction time.	1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate	28-90	interleukin 1 alpha	Homo sapiens	92-96
21092940-2	2011	CoSO(4) in an ionic liquid, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1), was found to be an efficient catalyst for the hydrolysis of cellulose at 150 C, which led to 84% conversion of MCC after 300min reaction time.	Cellulose	159-168	interleukin 1 alpha	Homo sapiens	92-96
21092940-2	2011	CoSO(4) in an ionic liquid, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1), was found to be an efficient catalyst for the hydrolysis of cellulose at 150 C, which led to 84% conversion of MCC after 300min reaction time.	microcrystalline cellulose	210-213	interleukin 1 alpha	Homo sapiens	92-96
21092940-5	2011	A mechanism for the CoSO(4)-IL-1 hydrolysis system was proposed and IL-1 was recycled for the first time, which exhibited favorable catalytic activity over five repeated runs.	cobalt sulfate	20-27	interleukin 1 alpha	Homo sapiens	28-32
21092940-5	2011	A mechanism for the CoSO(4)-IL-1 hydrolysis system was proposed and IL-1 was recycled for the first time, which exhibited favorable catalytic activity over five repeated runs.	cobalt sulfate	20-27	interleukin 1 alpha	Homo sapiens	68-72
22040886-0	2011	Dihydrotestosterone inhibits interleukin-1alpha or tumor necrosis factor alpha-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-kappaB activation in rheumatoid fibroblast-like synovial cell line.	Dihydrotestosterone	0-19	interleukin 1 alpha	Homo sapiens	29-47
22190974-2	2011	Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (alpha-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF.	alpha-galactocylceramide	97-121	interleukin 1 alpha	Homo sapiens	168-172
21525597-5	2011	Using cytokine protein arrays and real time gene expression analysis, we indeed found that low oxygen exposure increased expression of characteristic macrophage inflammatory cytokines such as IL-1, IL-6, and TNF-alpha.	Oxygen	95-101	interleukin 1 alpha	Homo sapiens	192-196
22152139-10	2011	NF-kappaB  activity and levels of TNF-alpha,IL-1 and IL-6 were lower in ulinastain group than control one, without any significant difference between the two groups.	ulinastain	72-82	interleukin 1 alpha	Homo sapiens	44-48
21112343-10	2011	Furthermore, JNK was involved in palmitate-induced expression of IL1A, IL8, CXCL3, SPP1 and CEBPB as determined with inhibitor SP600125 (all p&lt;0.05).	Palmitates	33-42	interleukin 1 alpha	Homo sapiens	65-69
21787135-6	2011	Visfatin and IL-1 promoted the catabolic degradation of both cartilage and meniscus, as evidenced by increased metalloproteinase activity, nitric oxide production, and proteoglycan release.	Nitric Oxide	139-151	interleukin 1 alpha	Homo sapiens	13-17
21954641-1	2011	The use of metformin during the first month of treatment of patients with coronary artery disease and diabetes type 2 led to the decrease of insulin resistance and reduced activity of systemic inflammation (significant decrease in the concentrations of IL-1, IL-6, IL-8 and TNF-alpha).	Metformin	11-20	interleukin 1 alpha	Homo sapiens	253-257
21112343-10	2011	Furthermore, JNK was involved in palmitate-induced expression of IL1A, IL8, CXCL3, SPP1 and CEBPB as determined with inhibitor SP600125 (all p&lt;0.05).	pyrazolanthrone	127-135	interleukin 1 alpha	Homo sapiens	65-69
21961050-6	2011	When alpha-tocopherol, CO(2)-SFE mussel oil, and 5beta-scymnol were added to the UVB-irradiated HEM cells treated with IL-1alpha, TNF-alpha levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells.	alpha-Tocopherol	5-21	interleukin 1 alpha	Homo sapiens	119-128
21792375-3	2011	Additionally, microglial cells release IL-1alpha/beta, reactive oxygen species (ROS), such as superoxide (O(2) (-)) and reactive nitrogen species (RNS) like nitric oxide (NO).	Superoxides	94-104	interleukin 1 alpha	Homo sapiens	39-48
21792375-3	2011	Additionally, microglial cells release IL-1alpha/beta, reactive oxygen species (ROS), such as superoxide (O(2) (-)) and reactive nitrogen species (RNS) like nitric oxide (NO).	Superoxides	106-110	interleukin 1 alpha	Homo sapiens	39-48
21792375-3	2011	Additionally, microglial cells release IL-1alpha/beta, reactive oxygen species (ROS), such as superoxide (O(2) (-)) and reactive nitrogen species (RNS) like nitric oxide (NO).	Reactive Nitrogen Species	120-145	interleukin 1 alpha	Homo sapiens	39-48
21792375-3	2011	Additionally, microglial cells release IL-1alpha/beta, reactive oxygen species (ROS), such as superoxide (O(2) (-)) and reactive nitrogen species (RNS) like nitric oxide (NO).	Nitric Oxide	157-169	interleukin 1 alpha	Homo sapiens	39-48
21961050-6	2011	When alpha-tocopherol, CO(2)-SFE mussel oil, and 5beta-scymnol were added to the UVB-irradiated HEM cells treated with IL-1alpha, TNF-alpha levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells.	scymnol	49-62	interleukin 1 alpha	Homo sapiens	119-128
21633494-7	2011	We show that STBM can bind to monocytes and B cells and induce cytokine release (TNFalpha, MIP-1alpha, IL-1alpha, IL-1beta, IL-6, IL-8).	stbm	13-17	interleukin 1 alpha	Homo sapiens	103-112
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	33-59	interleukin 1 alpha	Homo sapiens	75-84
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	61-64	interleukin 1 alpha	Homo sapiens	75-84
22040886-4	2011	Promoter analysis of the IL-8 gene revealed that nuclear factor (NF)-kappaB activation is critical for its transcriptional activation by IL-1alpha, and DHT inhibited the IL-1alpha-induced NF-kappaB activation in a manner dependent on the androgen receptor (AR).	Dihydrotestosterone	152-155	interleukin 1 alpha	Homo sapiens	170-179
21051736-5	2010	Mechanistically, minocycline decreased the permeability of the blood-brain barrier, inhibited microglial activation, decreased both the expression of IL1alpha and protein nitrosylation, and reduced the loss of GFAP immunoreactivity.	Minocycline	17-28	interleukin 1 alpha	Homo sapiens	150-158
20826144-10	2010	Moreover, tanshinone IIA could decrease the levels of MMP-9, TNF-alpha, IL-1alpha, IL-2, IFN-gamma and reactive oxygen species in leukocytes.	tanshinone	10-24	interleukin 1 alpha	Homo sapiens	72-81
21284261-3	2010	Roflumilast inhibited DNCB-stimulated IL-1alpha secretion in HaCaT cells, and reduced ear thickness and lymph node weights in BALB/c mice sensitized with DNCB.	Dinitrochlorobenzene	22-26	interleukin 1 alpha	Homo sapiens	38-47
20936646-1	2010	Microcrystalline cellulose (MCC) is hydrolyzed to an appreciable extent (70 %) by using 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1) as effective catalyst.	microcrystalline cellulose	0-26	interleukin 1 alpha	Homo sapiens	152-156
20826147-0	2010	4"-chlorodiazepam--agonist of peripheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes.	4'-chlorodiazepam	0-17	interleukin 1 alpha	Homo sapiens	92-96
20826147-4	2010	The present study shows that 4"-chlorodiazepam (Ro-54864), an agonist of peripheral benzodiazepine receptors, counteract inhibition of collagen and DNA biosynthesis, induced by IL-1.	4'-chlorodiazepam	29-46	interleukin 1 alpha	Homo sapiens	177-181
20826147-4	2010	The present study shows that 4"-chlorodiazepam (Ro-54864), an agonist of peripheral benzodiazepine receptors, counteract inhibition of collagen and DNA biosynthesis, induced by IL-1.	ro-54864	48-56	interleukin 1 alpha	Homo sapiens	177-181
20826147-11	2010	The data suggest that the mechanism of the protective effects of Ro-54864 on IL-1-induced effects in chondrocytes undergoes through mTOR and AKT signaling.	ro-54864	65-73	interleukin 1 alpha	Homo sapiens	77-81
20936646-1	2010	Microcrystalline cellulose (MCC) is hydrolyzed to an appreciable extent (70 %) by using 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1) as effective catalyst.	microcrystalline cellulose	28-31	interleukin 1 alpha	Homo sapiens	152-156
20936646-1	2010	Microcrystalline cellulose (MCC) is hydrolyzed to an appreciable extent (70 %) by using 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate (IL-1) as effective catalyst.	1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate	88-150	interleukin 1 alpha	Homo sapiens	152-156
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	ferrous chloride	35-40	interleukin 1 alpha	Homo sapiens	58-62
21062492-5	2010	The spinal cords of sALS (n = 8), but not control subjects (n = 4), were infiltrated by interleukin-1beta- (IL-1beta-), and tumor necrosis factor-alpha-positive macrophages (co-localizing with neurons), IL-17A-positive CD8 cells, and IL-17A-positive mast cells.	sals	20-24	interleukin 1 alpha	Homo sapiens	108-116
20800651-6	2010	In multivariate modeling with adjustments for age, gender, obesity, regular smoking, alcohol use, metabolic syndrome, physical exercise, sleep disturbance, and the use of non-steroidal anti-inflammatory drugs, a high level of IL-1 RA was associated with an increased likelihood of belonging to the group with elevated depressive symptoms (OR for each 1 SD increase in the serum level of IL-1 RA: 2.17, 95% CI 1.35-3.48, p=0.001).	Alcohols	85-92	interleukin 1 alpha	Homo sapiens	226-230
20974980-5	2010	Unlike other particulate Nlrp3 agonists, nano-TiO(2)-dependent-Nlrp3 activity does not require cytoskeleton-dependent phagocytosis and induces IL-1alpha/beta secretion in nonphagocytic keratinocytes.	titanium dioxide	46-52	interleukin 1 alpha	Homo sapiens	143-152
20974980-7	2010	Thus, the inflammation caused by nano-TiO(2) in vivo is largely caused by the biological effect of IL-1alpha.	tio	38-41	interleukin 1 alpha	Homo sapiens	99-108
20566195-8	2010	RESULTS: The expression of E-selectin on endothelium following stimulation with interleukin-1 is attenuated by the inotropes dopamine or dobutamine, but not by epinephrine.	Dopamine	125-133	interleukin 1 alpha	Homo sapiens	80-93
20872576-7	2010	We also showed that titanium particles trigger the recruitment of neutrophils and that this acute inflammatory response depends on the expression of the IL-1 receptor and IL-1alpha/beta.	Titanium	20-28	interleukin 1 alpha	Homo sapiens	171-180
21273654-2	2010	Brain IL-1 is an important mediator in stress-induced stimulation of the limbic-hypothalamic-pituitary-adrenal axis and secretion of ACTH and corticosterone.	Corticosterone	142-156	interleukin 1 alpha	Homo sapiens	6-10
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	microcrystalline cellulose	142-145	interleukin 1 alpha	Homo sapiens	58-62
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	Furaldehyde	182-190	interleukin 1 alpha	Homo sapiens	58-62
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	levulinic acid	287-301	interleukin 1 alpha	Homo sapiens	58-62
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	Sugars	326-332	interleukin 1 alpha	Homo sapiens	58-62
20936646-3	2010	Interestingly, the introduction of FeCl2 as catalyst into IL-1 further enhances the catalytic activity, as proved by the higher conversion of MCC (84 %) and higher yields of HMF and furfural (34 % and 19 %, respectively) under the same experimental conditions, although small amounts of levulinic acid (LA) and total reducing sugars (TRS) were also found.	Tromethamine	334-337	interleukin 1 alpha	Homo sapiens	58-62
20936646-6	2010	A mechanism to explain the high activity of FeCl2 in the IL-1 system is proposed.	ferrous chloride	44-49	interleukin 1 alpha	Homo sapiens	57-61
20619327-0	2010	Hexavalent chromium induced ROS formation, Akt, NF-kappaB, and MAPK activation, and TNF-alpha and IL-1alpha production in keratinocytes.	Chromium	11-19	interleukin 1 alpha	Homo sapiens	98-107
20566195-8	2010	RESULTS: The expression of E-selectin on endothelium following stimulation with interleukin-1 is attenuated by the inotropes dopamine or dobutamine, but not by epinephrine.	Dobutamine	137-147	interleukin 1 alpha	Homo sapiens	80-93
20566195-10	2010	The decrease in neutrophil adhesion to endothelium following stimulation with interleukin-1 and addition of inotropes is antagonised by the b-blocker butoxamine.	Butoxamine	150-160	interleukin 1 alpha	Homo sapiens	78-91
20599921-0	2010	Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity.	Doxorubicin	80-91	interleukin 1 alpha	Homo sapiens	18-31
20599921-2	2010	After finding a close connection between Interleukin-1 family and doxorubicin-induced cardiotoxicity, we assumed that recombinant human interleukin-1 receptor antagonist (rhIL-1Ra), the natural antagonist of interleukin-1, might have a protective role in doxorubicin-induced cardiotoxicity.	Doxorubicin	66-77	interleukin 1 alpha	Homo sapiens	136-149
20626741-5	2010	Enhanced serum concentrations of interleukin (IL)-1alpha and IL-1beta were observed in cITP (P &lt; 10(-3) ) and blood donor (P = 0 04) carriers of the IL1RN*2.	citp	87-91	interleukin 1 alpha	Homo sapiens	33-56
20920411-8	2010	RESULTS: Polyethylene occlusion alone with abrupt removal induced IL-8 and IL-1alpha levels similar to or exceeding that of SLS.	Polyethylene	9-21	interleukin 1 alpha	Homo sapiens	75-84
20920411-10	2010	CONCLUSION: Removal of occlusion with polyethylene film up-regulates the inflammatory cytokines IL-8, IL-1alpha, and IL-1RA in patients with AD.	Polyethylene	38-50	interleukin 1 alpha	Homo sapiens	102-111
20973418-4	2010	IL-1 and TNF induce expression of other mediators that amplify the inflammatory response, such as prostaglandins, and lead to production of lytic enzymes and stimulate the production of chemokines.	Prostaglandins	98-112	interleukin 1 alpha	Homo sapiens	0-4
20696083-6	2010	Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group.	Carrageenan	125-141	interleukin 1 alpha	Homo sapiens	65-74
20558185-7	2010	While the benzofurylquinazolines increased the expression level of the pro-inflammatory gene IL1-alpha as well as p21 and p53 in the PC3 cell line, a phenylpyrrolocarbazole had the converse effect on p53 expression.	benzofurylquinazolines	10-32	interleukin 1 alpha	Homo sapiens	93-102
20489149-6	2010	ROS production and OS were increased in IL-1alpha/IFNgamma-incubated thyrocytes and in destructive thyroiditis.	Reactive Oxygen Species	0-3	interleukin 1 alpha	Homo sapiens	40-49
20564616-10	2010	To confirm paracrine signaling a twofold increase in IL-1 alpha was measured in keratinocyte-conditioned medium after incubation with SDS or Formi, which correlated with fibroblast NF-kappaB activity.	Sodium Dodecyl Sulfate	134-137	interleukin 1 alpha	Homo sapiens	53-63
20564616-10	2010	To confirm paracrine signaling a twofold increase in IL-1 alpha was measured in keratinocyte-conditioned medium after incubation with SDS or Formi, which correlated with fibroblast NF-kappaB activity.	formi	141-146	interleukin 1 alpha	Homo sapiens	53-63
20599921-2	2010	After finding a close connection between Interleukin-1 family and doxorubicin-induced cardiotoxicity, we assumed that recombinant human interleukin-1 receptor antagonist (rhIL-1Ra), the natural antagonist of interleukin-1, might have a protective role in doxorubicin-induced cardiotoxicity.	Doxorubicin	255-266	interleukin 1 alpha	Homo sapiens	136-149
20845101-11	2010	Dexamethasone significantly reduced postoperative levels of CRP (p = 0.01), IL-6 and IL-1 (p &lt; 0.05), fatigue (p = 0.01) and overall pain during the first 24 postoperative hours (p &lt; 0.05) and the total requirement of analgesic (ketorolac) (p &lt; 0.05).	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	85-89
20489149-7	2010	In vitro, NAC not only reduced ROS production below control levels, but further decreased the expression of thyroid-specific proteins in addition to IL-1alpha/IFNgamma-inhibitory effects.	Acetylcysteine	10-13	interleukin 1 alpha	Homo sapiens	149-158
20531411-8	2010	Metronomic gemcitabine also significantly increased apoptosis in cancer-associated fibroblasts and induced greater reductions in the tumour levels of multiple pro-angiogenic factors, including EGF, IL-1alpha, IL-8, ICAM-1, and VCAM-1.	gemcitabine	11-22	interleukin 1 alpha	Homo sapiens	198-207
20540705-4	2010	Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFalpha, TRAIL, Fas ligand), cytokines (IL-1, IFNgamma), radiation, pathogenic infections, cytotoxic agents and others.	Ceramides	25-33	interleukin 1 alpha	Homo sapiens	217-221
20595916-0	2010	Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.	Beryllium	70-79	interleukin 1 alpha	Homo sapiens	20-25
20595916-0	2010	Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.	Beryllium	92-101	interleukin 1 alpha	Homo sapiens	20-25
20205531-8	2010	Additionally, COS inhibited expression of inducible nitric oxide synthase and interleukin-1 and activated interleukin-10 more effectively than GLT.	carbonyl sulfide	14-17	interleukin 1 alpha	Homo sapiens	78-120
20202487-10	2010	RESULTS: IL-1 increased MMP activity, S-GAG release, and NO production, while decreasing the shear strength and tissue repair in the interface.	Glycosaminoglycans	40-43	interleukin 1 alpha	Homo sapiens	9-13
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	interleukin 1 alpha	Homo sapiens	181-184
20069635-4	2010	Human knee articular cartilage explants were sorted according to the degree of OA and treated for 10 days with tetracycline derivatives in the presence of interleukin-1 (IL-1beta).	Tetracycline	111-123	interleukin 1 alpha	Homo sapiens	155-168
20346081-9	2010	Dexamethasone, at 50 microg/ml, decreased the viability of HRECs stimulated by IL-1alpha, IL-1beta, IL-6 and VEGF without hyalocytes but could not decrease the viability of HRECs cocultured.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	79-88
20178837-7	2010	Acute intrathecal (+)-methadone and (+)-morphine were also found to induce microglial, interleukin-1 and TLR4/myeloid differentiation factor-2 (MD-2) dependent enhancement of pain responsivity.	Methadone	18-31	interleukin 1 alpha	Homo sapiens	87-100
20178837-7	2010	Acute intrathecal (+)-methadone and (+)-morphine were also found to induce microglial, interleukin-1 and TLR4/myeloid differentiation factor-2 (MD-2) dependent enhancement of pain responsivity.	Morphine	36-48	interleukin 1 alpha	Homo sapiens	87-100
19618379-8	2010	RESULTS: In comparison with their counterparts without APOE4, patients with at least one copy of the APOE epsilon-4 allele showed higher spontaneous (p = 0.037) and PMA-induced (p = 0.039) production of IL-1beta after controlling for clinical variables.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 alpha	Homo sapiens	203-211
19965584-8	2010	Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2alpha) levels.	Prostaglandins F	63-66	interleukin 1 alpha	Homo sapiens	19-29
20108067-0	2010	1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.	Hydrogen	0-2	interleukin 1 alpha	Homo sapiens	71-89
20108067-0	2010	1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.	13c	4-7	interleukin 1 alpha	Homo sapiens	71-89
20108067-0	2010	1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.	15n	12-15	interleukin 1 alpha	Homo sapiens	71-89
20507366-5	2010	RESULTS: Ex vivo human whole blood assays indicated that triclosan significantly down-regulated the LPS-stimulated expression of Toll-like receptor signalling molecules and other multiple inflammatory molecules including IL-1 and IL-6 and the dampening of signals that activate the T-helper type 1 acquired immune response via suppression of CD70 with concomitant up-regulation of growth factors related to bone morphogenetic protein (BMP)2 and BMP6 synthesis.	Triclosan	57-66	interleukin 1 alpha	Homo sapiens	221-225
20019678-7	2010	Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor.	Glucose	8-15	interleukin 1 alpha	Homo sapiens	83-92
20338604-10	2010	The enoxolone solution induced a decrease of IL1alpha.	Glycyrrhetinic Acid	4-13	interleukin 1 alpha	Homo sapiens	45-53
19813262-0	2010	Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses.	Minocycline	65-76	interleukin 1 alpha	Homo sapiens	96-105
19813262-0	2010	Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses.	Doxycycline	81-92	interleukin 1 alpha	Homo sapiens	96-105
20005289-2	2010	We have previously reported that evodiamine has a marked inhibitory effect on IL-1 sensitive human melanoma A375-S2 cells proliferation, and this action might be through inactivation of PI3K signaling.	evodiamine	33-43	interleukin 1 alpha	Homo sapiens	78-82
20036937-6	2010	Administration of resveratrol can inhibit NF-kappaB activity as well as reduce the concentrations of TNF-alpha, IL-6 and IL-1.	Resveratrol	18-29	interleukin 1 alpha	Homo sapiens	121-125
20118567-5	2010	The production of IL-1alpha and -1beta stimulated with lipopolysaccharide was significantly increased in the presence of amlodipine.	Amlodipine	121-131	interleukin 1 alpha	Homo sapiens	18-38
20118567-7	2010	Amlodipine and diltiazem significantly increased production of IL-1alpha stimulated with concanavalin A.	Amlodipine	0-10	interleukin 1 alpha	Homo sapiens	63-72
20118567-7	2010	Amlodipine and diltiazem significantly increased production of IL-1alpha stimulated with concanavalin A.	Diltiazem	15-24	interleukin 1 alpha	Homo sapiens	63-72
20118567-8	2010	Nifedipine inhibited production of IL-1alpha, IL-6, and IFN-gamma.	Nifedipine	0-10	interleukin 1 alpha	Homo sapiens	35-44
24278500-9	2010	Lomefloxacin increased the interleukin-1alpha release after 15 minutes of exposure and 42 hours of post incubation, although no decrease in viability was observed.	lomefloxacin	0-12	interleukin 1 alpha	Homo sapiens	27-45
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	interleukin 1 alpha	Homo sapiens	107-111
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	interleukin 1 alpha	Homo sapiens	129-133
19926874-6	2010	In contrast, secondary necrotic VSMCs release both IL-1alpha and caspase-activated IL-1beta, augmenting IL-6 and MCP-1 production.	vsmcs	32-37	interleukin 1 alpha	Homo sapiens	51-60
19602113-2	2010	A broad-spectrum AMP, calprotectin (a complex of S100A8 and S100A9 proteins), is expressed by oral epithelial cells and is up-regulated by interleukin-1alpha (IL-1alpha).	Adenosine Monophosphate	17-20	interleukin 1 alpha	Homo sapiens	139-157
19602113-2	2010	A broad-spectrum AMP, calprotectin (a complex of S100A8 and S100A9 proteins), is expressed by oral epithelial cells and is up-regulated by interleukin-1alpha (IL-1alpha).	Adenosine Monophosphate	17-20	interleukin 1 alpha	Homo sapiens	159-168
19602113-4	2010	The purpose of this study was to investigate the effect of SST on the expression of calprotectin and other AMPs through the regulation of IL-1alpha in oral epithelial cells.	Adenylyl sulfate	107-111	interleukin 1 alpha	Homo sapiens	138-147
19878710-0	2010	A comparative study of leukaemia inhibitory factor and interleukin-1alpha intracellular content in a human keratinocyte cell line after exposure to cosmetic fragrances and sodium dodecyl sulphate.	Sodium Dodecyl Sulfate	172-195	interleukin 1 alpha	Homo sapiens	55-73
19913562-0	2010	Nitric oxide and peroxynitrite induce gene expression of interleukin receptors increasing IL-21, IL-7, IL-1 and oncostatin M in cardiomyocytes.	Nitric Oxide	0-12	interleukin 1 alpha	Homo sapiens	103-107
19913562-0	2010	Nitric oxide and peroxynitrite induce gene expression of interleukin receptors increasing IL-21, IL-7, IL-1 and oncostatin M in cardiomyocytes.	Peroxynitrous Acid	17-30	interleukin 1 alpha	Homo sapiens	103-107
20950476-2	2010	The objective of the present study was to determine the effect of a long-acting IL-1 receptor inhibitor, AMG 108, in a double-blind, placebo-controlled, parallel-dosing study in patients with active RA who were receiving stable methotrexate (15 to 25 mg/week).	Methotrexate	228-240	interleukin 1 alpha	Homo sapiens	80-84
19618379-6	2010	PBMCs were isolated from the donors and used to assess spontaneous and PMA-stimulated secretion of TNF-alpha, IL-6, and IL-1beta.	Tetradecanoylphorbol Acetate	71-74	interleukin 1 alpha	Homo sapiens	120-128
20413861-8	2010	Stimulation by rAbeta42 also induces the production of the pro-inflammatory cytokines IL-1beta, IL-6, IFN-gamma, and TNF-alpha, and of the anti-inflammatory cytokines IL-10 and IL-1Ra.	rabeta42	15-23	interleukin 1 alpha	Homo sapiens	86-94
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	Curcumin	153-161	interleukin 1 alpha	Homo sapiens	4-8
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	pyrazolanthrone	166-174	interleukin 1 alpha	Homo sapiens	4-8
19800021-8	2010	IL-1 induced NF-kappaB DNA binding and activation by this transcription factor and this was attenuated by curcumin and apigenin.	Curcumin	106-114	interleukin 1 alpha	Homo sapiens	0-4
20391135-5	2010	In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion.	Polycyclic Aromatic Hydrocarbons	47-50	interleukin 1 alpha	Homo sapiens	79-92
20391135-5	2010	In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion.	Polycyclic Aromatic Hydrocarbons	47-50	interleukin 1 alpha	Homo sapiens	94-105
20391135-11	2010	Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion.	1-methylpyrene	8-22	interleukin 1 alpha	Homo sapiens	93-102
20391135-11	2010	Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion.	Perylene	26-34	interleukin 1 alpha	Homo sapiens	93-102
19764937-5	2009	RESULTS: Alcohol-dependent patients showed an excess of IL-1alpha-889 C/T [50.8% vs. 39.3%, chi(2) (df) = 7.30 (2), uncorrected p = 0.026, corrected p = 0.104] and IL-1RA (86 bp)(n) A1/A1 genotypes [64.8% vs. 50.8%, chi(2) (df) = 12.65 (3), corrected p = 0.020].	Alcohols	9-16	interleukin 1 alpha	Homo sapiens	56-65
19602125-4	2009	MATERIAL AND METHODS: Differences in the expression of interleukin-1, interleukin-8 and RANKL mRNAs, in response to exposure to various concentrations of nicotine (0, 0.125, 0.25, 0.5 and 1 mm) were evaluated in U2OS cells using the reverse transcription-polymerase chain reaction.In addition, the levels of interleukin-1, interleukin-8 and RANKL proteins were determined using enzyme-linked immunosorbent assays.	Nicotine	154-162	interleukin 1 alpha	Homo sapiens	55-68
19787300-7	2009	The chronic exposure to arsenic upregulates the expression of tumor necrosis factor-alpha, interleukin-1, vascular cell adhesion molecule and vascular endothelial growth factor to induce cardiovascular pathogenesis.	Arsenic	24-31	interleukin 1 alpha	Homo sapiens	91-104
19602125-6	2009	RESULTS: Nicotine was found to increase the expression of interleukin-1, interleukin-8 and RANKL mRNA and protein in U2OS cells (p &lt; 0.05).	Nicotine	9-17	interleukin 1 alpha	Homo sapiens	58-71
19997482-10	2009	An interesting finding is that the selective EGFR inhibitor Gefitinib inhibits signaling downstream the Interleukin-1alpha (IL1alpha) pathway; an effect that cannot be extracted from binding affinity-based approaches.	Gefitinib	60-69	interleukin 1 alpha	Homo sapiens	104-122
19559678-2	2009	Odoroside A [3beta-O-(beta-D-diginosyl)-14-hydroxy-5beta,14beta-card-20(22)-enolide] was found to inhibit the cell-surface expression of ICAM-1 induced by TNF-alpha and IL-1 at comparable concentrations in human lung carcinoma A549 cells.	Odoroside A	0-11	interleukin 1 alpha	Homo sapiens	169-173
19559678-2	2009	Odoroside A [3beta-O-(beta-D-diginosyl)-14-hydroxy-5beta,14beta-card-20(22)-enolide] was found to inhibit the cell-surface expression of ICAM-1 induced by TNF-alpha and IL-1 at comparable concentrations in human lung carcinoma A549 cells.	3beta-o-(beta-d-diginosyl)-14-hydroxy-5beta	13-56	interleukin 1 alpha	Homo sapiens	169-173
19633559-4	2009	In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis.	Silicon Dioxide	121-127	interleukin 1 alpha	Homo sapiens	97-101
19633559-4	2009	In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis.	Bleomycin	141-150	interleukin 1 alpha	Homo sapiens	97-101
19228263-0	2009	Human cardiac fibroblasts express B-type natriuretic peptide: fluvastatin ameliorates its up-regulation by interleukin-1alpha, tumour necrosis factor-alpha and transforming growth factor-beta.	Fluvastatin	62-73	interleukin 1 alpha	Homo sapiens	107-125
19845487-12	2009	H(2)O(2) was inhibited by 72%, nitrate 96%, TNF 90%, IL1 21%, IL6 42%.	Hydrogen Peroxide	0-8	interleukin 1 alpha	Homo sapiens	53-56
19654051-5	2009	When HUVEC incubated with L-NMMA were stimulated with low concentrations of IL-1alpha (0.05-0.5ng/mL), these determined a higher VCAM-1 expression than in the presence of L-NMMA or IL-1alpha alone.	omega-N-Methylarginine	26-32	interleukin 1 alpha	Homo sapiens	76-85
19654051-5	2009	When HUVEC incubated with L-NMMA were stimulated with low concentrations of IL-1alpha (0.05-0.5ng/mL), these determined a higher VCAM-1 expression than in the presence of L-NMMA or IL-1alpha alone.	omega-N-Methylarginine	26-32	interleukin 1 alpha	Homo sapiens	181-190
19654051-5	2009	When HUVEC incubated with L-NMMA were stimulated with low concentrations of IL-1alpha (0.05-0.5ng/mL), these determined a higher VCAM-1 expression than in the presence of L-NMMA or IL-1alpha alone.	omega-N-Methylarginine	171-177	interleukin 1 alpha	Homo sapiens	76-85
20079164-6	2009	RESULTS: IL-1 lowered the mRNA level and protein expression of Sox9 and collagen type II in the cultured intervertebral disc cells in a dose dependent manner (P &lt; 0.05), and this effect was attenuated by curcumin.	Curcumin	207-215	interleukin 1 alpha	Homo sapiens	9-13
20079164-8	2009	IL-1 at concentrations of 0.1 ng/ml, 1 ng/ml and 10 ng/ml could stimulate the activity of NF-kappaB in the intervertebral disc cells in a dose dependent manner (P &lt; 0.05) that was inhibited by curcumin.	Curcumin	196-204	interleukin 1 alpha	Homo sapiens	0-4
19748989-2	2009	Accruing evidence suggests that extracellular ATP participates in the inflammatory response as a proinflammatory mediator by activating the inflammasome complex, inducing secretion of cytokines (IL-1, IL-18) and cell damaging agents such as oxygen radicals, cationic proteins, and metalloproteases.	Adenosine Triphosphate	46-49	interleukin 1 alpha	Homo sapiens	195-199
19857103-7	2009	Additional experimentation was performed in which testing solutions were replaced with media after 1 h and the resulting supernatants quantified after 24 h. RESULTS: BAK induced significant amounts of interleukin (IL-) 1 and tumor necrosis factor (TNF), but only moderate amounts of C-reactive protein (CRP), IL- 10 and 12, and H(2)O(2).	Benzalkonium Compounds	166-169	interleukin 1 alpha	Homo sapiens	201-220
19857103-10	2009	Lipopolysaccharide (LPS) positive controls induced substantial elaboration/release of both IL-1 and TNF as did in increasing the exposure to the full 24 h. CONCLUSIONS: After 1 h of exposure, BAK increased quantities of all biomarkers.	Benzalkonium Compounds	192-195	interleukin 1 alpha	Homo sapiens	91-95
19484185-4	2009	After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1alpha levels were significantly higher in the patients with late-life depression than in the normal control subjects.	Triglycerides	74-86	interleukin 1 alpha	Homo sapiens	99-108
19651324-12	2009	Additionally, SM upregulates many inflammatory mediators including interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and others.	Mustard Gas	14-16	interleukin 1 alpha	Homo sapiens	67-90
19997482-10	2009	An interesting finding is that the selective EGFR inhibitor Gefitinib inhibits signaling downstream the Interleukin-1alpha (IL1alpha) pathway; an effect that cannot be extracted from binding affinity-based approaches.	Gefitinib	60-69	interleukin 1 alpha	Homo sapiens	124-132
19702951-10	2009	The siRNA for beta-catenin suppressed the IL-1alpha-induced OPG production in both PDL cells and hGFs, whereas the AP-1 inhibitor curcumin augmented the IL-1alpha-induced OPG production in PDL cells, but not in hGFs.	Curcumin	130-138	interleukin 1 alpha	Homo sapiens	153-162
19825520-0	2009	Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes.	Mevalonic Acid	34-44	interleukin 1 alpha	Homo sapiens	66-70
19825520-0	2009	Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes.	Mevalonic Acid	34-44	interleukin 1 alpha	Homo sapiens	86-90
19825520-7	2009	RESULTS: Pharmacological inhibition of the mevalonate pathway specifically enhanced the release of IL-1alpha, IL-1beta and IL-18 and inhibited IL-1ra production by LPS-activated PBMCs and THP-1 cells.	Mevalonic Acid	43-53	interleukin 1 alpha	Homo sapiens	99-108
19825520-11	2009	CONCLUSION: Pharmacological inhibition of the mevalonate pathway by statins highlighted the specific induction of the proinflammatory cytokines of the IL-1 family whose maturation is either directly (i.e. IL-1beta and IL-18), or indirectly (i.e. IL-1alpha) dependant on caspase-1.	Mevalonic Acid	46-56	interleukin 1 alpha	Homo sapiens	151-155
19825520-11	2009	CONCLUSION: Pharmacological inhibition of the mevalonate pathway by statins highlighted the specific induction of the proinflammatory cytokines of the IL-1 family whose maturation is either directly (i.e. IL-1beta and IL-18), or indirectly (i.e. IL-1alpha) dependant on caspase-1.	Mevalonic Acid	46-56	interleukin 1 alpha	Homo sapiens	246-255
19497848-1	2009	Calcium (Ca2+) signaling by the pro-inflammatory cytokine interleukin-1 (IL-1) is dependent on focal adhesions, which contain diverse structural and signaling proteins including protein phosphatases.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	58-71
19559609-2	2009	In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1.	peperomin E	43-54	interleukin 1 alpha	Homo sapiens	149-162
19559609-2	2009	In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1.	2,6-didehydropeperomin B	59-83	interleukin 1 alpha	Homo sapiens	149-162
19497848-1	2009	Calcium (Ca2+) signaling by the pro-inflammatory cytokine interleukin-1 (IL-1) is dependent on focal adhesions, which contain diverse structural and signaling proteins including protein phosphatases.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	73-77
19576795-5	2009	The IL-1 alpha-mediated response required a selective interaction of virus arginine-glycine-aspartic acid (RGD) motifs with macrophage beta(3) integrins.	arginyl-glycyl-aspartic acid	75-105	interleukin 1 alpha	Homo sapiens	4-14
19156359-8	2009	This increase could also be induced by macrophage-conditioned medium, tumor necrosis factor-alpha, IL-1alpha, and IL-1beta, and could be suppressed by anti-inflammatory agents including pyrrolidine dithiocarbamate, pentoxifylline, or dexamethasone.	Dexamethasone	234-247	interleukin 1 alpha	Homo sapiens	99-108
19542372-5	2009	In addition to TNF-alpha, IL-1alpha and IL-1beta promoted caspase-1 activation via Nlrp3 in response to ATP.	Adenosine Triphosphate	104-107	interleukin 1 alpha	Homo sapiens	26-35
19551668-1	2009	PURPOSE: To evaluate the effect of topical N-acetylcysteine (NAC) on interleukin 1-alpha (IL-1alpha) levels in tear fluid after myopic laser subepithelial keratectomy (LASEK) and its possible role in modulating corneal wound healing.	Acetylcysteine	43-59	interleukin 1 alpha	Homo sapiens	69-88
19551668-1	2009	PURPOSE: To evaluate the effect of topical N-acetylcysteine (NAC) on interleukin 1-alpha (IL-1alpha) levels in tear fluid after myopic laser subepithelial keratectomy (LASEK) and its possible role in modulating corneal wound healing.	Acetylcysteine	43-59	interleukin 1 alpha	Homo sapiens	90-99
19551668-1	2009	PURPOSE: To evaluate the effect of topical N-acetylcysteine (NAC) on interleukin 1-alpha (IL-1alpha) levels in tear fluid after myopic laser subepithelial keratectomy (LASEK) and its possible role in modulating corneal wound healing.	Acetylcysteine	61-64	interleukin 1 alpha	Homo sapiens	69-88
19551668-1	2009	PURPOSE: To evaluate the effect of topical N-acetylcysteine (NAC) on interleukin 1-alpha (IL-1alpha) levels in tear fluid after myopic laser subepithelial keratectomy (LASEK) and its possible role in modulating corneal wound healing.	Acetylcysteine	61-64	interleukin 1 alpha	Homo sapiens	90-99
19551668-14	2009	CONCLUSIONS: NAC seems to have an additive effect to steroids in suppressing IL-1alpha levels in tear fluid and may be clinically advantageous in modulating corneal wound healing during the early postoperative period after LASEK.	Acetylcysteine	13-16	interleukin 1 alpha	Homo sapiens	77-86
19551668-14	2009	CONCLUSIONS: NAC seems to have an additive effect to steroids in suppressing IL-1alpha levels in tear fluid and may be clinically advantageous in modulating corneal wound healing during the early postoperative period after LASEK.	Steroids	53-61	interleukin 1 alpha	Homo sapiens	77-86
19542427-6	2009	Production of IL-1alpha, IL-10, IL-17, IFN-gamma, G-CSF, GM-CSF, TNF-alpha, and IFN-inducible protein 10 (IP-10) correlated significantly with in vitro steroid sensitivity; however, only IL-2 and TNF-alpha reduced steroid sensitivity when added exogenously.	Steroids	152-159	interleukin 1 alpha	Homo sapiens	14-23
19522763-4	2009	In addition, poly I:C treatment inhibited cell growth and triggered up-regulation of IL-12p40, IL-8 and Il-1alpha in Detroit 562 cell line.	Poly I-C	13-21	interleukin 1 alpha	Homo sapiens	104-113
19210337-2	2009	Interleukin-1alpha induces prostaglandin E(2) production via cyclooxygenase-2 in human periodontal ligament cells.	Dinoprostone	27-45	interleukin 1 alpha	Homo sapiens	0-18
18975039-8	2009	In the presence of IL-1, the broad-spectrum MMP inhibitor GM 6001 decreased the MMP activity in the media, increased the shear strength of repair, and enhanced tissue repair in the interface.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	58-65	interleukin 1 alpha	Homo sapiens	19-23
19445695-8	2009	Combinations between EGF, sCD40L, VEGF, TGF-alpha and IL-1alpha also showed potential to differentiate between TB infection states.	Terbium	111-113	interleukin 1 alpha	Homo sapiens	54-63
19291322-9	2009	Menadione, a superoxide releasing oxidant stressor, causes a significant (p &lt; 0.001) increase in neuronal cell death as well as in the release of tumor necrosis factor alpha, interleukin-1, macrophage inflammatory protein alpha, and RANTES from cultured neurons.	Vitamin K 3	0-9	interleukin 1 alpha	Homo sapiens	178-230
19252469-4	2009	SP stimulates the production of hematopoietic cytokines (e.g. IL-1, IL-3, IL-6, SCF, GM-CSF) by bone marrow stromal cells.	TFF2 protein, human	0-2	interleukin 1 alpha	Homo sapiens	62-66
19398228-7	2009	Silybin (25-50 microM), inhibited the IL-1-induced synthesis of MCP-1 (P &lt; 0.01) and IL-8 (P &lt; 0.01) showing a potent anti-inflammatory activity.	Silybin	0-7	interleukin 1 alpha	Homo sapiens	38-42
19210337-0	2009	Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells.	Dinoprostone	25-41	interleukin 1 alpha	Homo sapiens	106-124
19617655-8	2009	At 10 mM, propionate also inhibited the interleukin-1 (IL- 1)-mediated VCAM-1 and ICAM-1 expression, with the latter effect being more pronounced, as well as decreased the TNF-alpha-induced VCAM-1 and ICAM-1 mRNA expression in a similar manner.	Propionates	10-20	interleukin 1 alpha	Homo sapiens	40-60
19307177-5	2009	These results demonstrate that the phosphorylation of Ser-172 and the activation of TBK1 and IKKepsilon are catalyzed by a distinct protein kinase(s) in vivo and that TBK1 and IKKepsilon control a feedback loop that limits their activation by LPS, poly(I:C) and IL-1alpha (but not tumor necrosis factor alpha) to prevent the hyperactivation of these enzymes.	Serine	54-57	interleukin 1 alpha	Homo sapiens	262-271
19265712-6	2009	Menadione causes a significant (p&lt;0.001) increase in endothelial cell death as well as an increase in RNA and protein levels of tumor necrosis factor alpha, interleukin-1, macrophage inflammatory protein alpha, and RANTES.	Vitamin K 3	0-9	interleukin 1 alpha	Homo sapiens	160-173
18705650-8	2009	Naringenin also markedly inhibited the secretion of interleukin (IL)-1alpha (by 59%), IL-23 (by 87%) and monocyte chemoattractant protein-1 (by 58%).	naringenin	0-10	interleukin 1 alpha	Homo sapiens	52-75
19298660-5	2009	RESULTS: In response to TNF-alpha or IL-1alpha, PAK1 was promptly activated, as characterized by a sequential phosphorylation, initiated at threonine-212 followed by at threonine-423 in the activation loop of the kinase, in human skin keratinocytes, dermal fibroblasts, and rat hepatic stellate cells.	Threonine	140-149	interleukin 1 alpha	Homo sapiens	37-46
19298660-5	2009	RESULTS: In response to TNF-alpha or IL-1alpha, PAK1 was promptly activated, as characterized by a sequential phosphorylation, initiated at threonine-212 followed by at threonine-423 in the activation loop of the kinase, in human skin keratinocytes, dermal fibroblasts, and rat hepatic stellate cells.	Threonine	169-178	interleukin 1 alpha	Homo sapiens	37-46
19245983-8	2009	Morphine and bupivacaine both inhibited the expected rise in NO and PGE(2) when interleukin-1 was added to the media.	Morphine	0-8	interleukin 1 alpha	Homo sapiens	80-93
19245983-8	2009	Morphine and bupivacaine both inhibited the expected rise in NO and PGE(2) when interleukin-1 was added to the media.	Bupivacaine	13-24	interleukin 1 alpha	Homo sapiens	80-93
19245983-8	2009	Morphine and bupivacaine both inhibited the expected rise in NO and PGE(2) when interleukin-1 was added to the media.	Prostaglandins E	68-71	interleukin 1 alpha	Homo sapiens	80-93
19333898-3	2009	Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA.	fostamatinib	32-44	interleukin 1 alpha	Homo sapiens	132-136
19210337-4	2009	In the present study, we investigated whether interleukin-1alpha induced vascular endothelial growth factor production in human periodontal ligament cells and whether cyclooxygenase-2-derived prostaglandin E(2) regulated interleukin-1alpha-induced vascular endothelial growth factor production.	Prostaglandins E	192-207	interleukin 1 alpha	Homo sapiens	221-239
19210337-10	2009	The interleukin-1alpha-induced vascular endothelial growth factor mRNA and protein expression was inhibited to the same extent by indomethacin and NS-398.	Indomethacin	130-142	interleukin 1 alpha	Homo sapiens	4-22
19210337-10	2009	The interleukin-1alpha-induced vascular endothelial growth factor mRNA and protein expression was inhibited to the same extent by indomethacin and NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	147-153	interleukin 1 alpha	Homo sapiens	4-22
19210337-11	2009	Indomethacin and NS-398 completely inhibited interleukin-1alpha-induced prostaglandin E(2) production.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	45-63
19210337-11	2009	Indomethacin and NS-398 completely inhibited interleukin-1alpha-induced prostaglandin E(2) production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	17-23	interleukin 1 alpha	Homo sapiens	45-63
19210337-11	2009	Indomethacin and NS-398 completely inhibited interleukin-1alpha-induced prostaglandin E(2) production.	Dinoprostone	72-90	interleukin 1 alpha	Homo sapiens	45-63
19210337-12	2009	Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production.	Dinoprostone	10-28	interleukin 1 alpha	Homo sapiens	136-154
19210337-12	2009	Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production.	butaprost	30-39	interleukin 1 alpha	Homo sapiens	136-154
19210337-12	2009	Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production.	dibutyryl	70-79	interleukin 1 alpha	Homo sapiens	136-154
19210337-12	2009	Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production.	Cyclic AMP	80-84	interleukin 1 alpha	Homo sapiens	136-154
19210337-12	2009	Exogenous prostaglandin E(2), butaprost (an EP2 receptor agonist) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha-induced vascular endothelial growth factor production.	Indomethacin	120-132	interleukin 1 alpha	Homo sapiens	136-154
19210337-13	2009	CONCLUSION: We suggest that interleukin-1alpha induced vascular endothelial growth factor production via cyclooxygenase-2-derived prostaglandin E(2) in human periodontal ligament cells.	Dinoprostone	130-148	interleukin 1 alpha	Homo sapiens	28-46
19210337-14	2009	The interleukin-1alpha/prostaglandin E(2) pathway might regulate vascular endothelial growth factor production in periodontal lesions.	Dinoprostone	23-41	interleukin 1 alpha	Homo sapiens	4-22
19182376-4	2009	We detected the induction of IL-1alpha expression and its secretion into the cell culture medium by treatment with 0.075% SDS for 18 h in LabCyte culture using DNA microarray, quantitative reverse-transcription polymerase chain reaction (RT-PCR) and ELISA.	Sodium Dodecyl Sulfate	122-125	interleukin 1 alpha	Homo sapiens	29-38
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	trichostatin A	69-83	interleukin 1 alpha	Homo sapiens	143-147
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	trichostatin A	85-88	interleukin 1 alpha	Homo sapiens	143-147
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	Butyric Acid	91-103	interleukin 1 alpha	Homo sapiens	143-147
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	Butyric Acid	105-107	interleukin 1 alpha	Homo sapiens	143-147
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	Valproic Acid	114-127	interleukin 1 alpha	Homo sapiens	143-147
19115247-2	2009	We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic acid (BA) prevented IL-1-induced mPGES-1 protein expression in human synovial fibroblasts.	Butyric Acid	129-131	interleukin 1 alpha	Homo sapiens	143-147
19115247-3	2009	TSA also inhibited IL-1-induced mPGES-1 mRNA expression and promoter activation.	trichostatin A	0-3	interleukin 1 alpha	Homo sapiens	19-23
18808414-9	2009	MK801 suppressed the production of interleukin-1alpha by keratinocytes induced by oleic acid.	Dizocilpine Maleate	0-5	interleukin 1 alpha	Homo sapiens	35-53
19110321-2	2009	Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6).	Curcumin	62-70	interleukin 1 alpha	Homo sapiens	308-339
19220089-1	2009	PURPOSE: To determine the potential efficacy of intravenous (IV) infusion of pentoxifylline (PTX) before nephrolithotomy on attenuating plasma level of the tumor necrosis factor (TNF)-alpha and interleukin (IL)-1, and to investigate whether it prevents postoperative pain.	Pentoxifylline	77-91	interleukin 1 alpha	Homo sapiens	194-212
19220089-1	2009	PURPOSE: To determine the potential efficacy of intravenous (IV) infusion of pentoxifylline (PTX) before nephrolithotomy on attenuating plasma level of the tumor necrosis factor (TNF)-alpha and interleukin (IL)-1, and to investigate whether it prevents postoperative pain.	Pentoxifylline	93-96	interleukin 1 alpha	Homo sapiens	194-212
19016711-6	2009	RESULTS: Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased the expression of KRT2 and IL-1alpha compared with vehicle-treated skin.	R 115866	9-19	interleukin 1 alpha	Homo sapiens	156-165
18808414-9	2009	MK801 suppressed the production of interleukin-1alpha by keratinocytes induced by oleic acid.	Oleic Acid	82-92	interleukin 1 alpha	Homo sapiens	35-53
19642305-4	2009	Overproduction of cytokines IL-1 alpha, IL-1 beta and TNF-alpha increases bone resorption, which is further accelerated by hyperparathyroidism connected with malabsorption of calcium and vitamin D.	Calcium	175-182	interleukin 1 alpha	Homo sapiens	28-38
19642305-4	2009	Overproduction of cytokines IL-1 alpha, IL-1 beta and TNF-alpha increases bone resorption, which is further accelerated by hyperparathyroidism connected with malabsorption of calcium and vitamin D.	Vitamin D	187-196	interleukin 1 alpha	Homo sapiens	28-38
19139781-5	2009	RESULTS: Silymarin reduces significantly serum levels of IL-1 alpha and IL-8, C3 and C4 after 8 weeks compared to the pre-treatment levels.	Silymarin	9-18	interleukin 1 alpha	Homo sapiens	57-67
19026558-1	2009	Expression of interleukin-1 receptor type II (IL1R2), a decoy receptor for pro-inflammatory interleukin 1 (IL-1), is enhanced by chronic exposure of the human uroepithelial cell line HUC-1 to arsenite.	arsenite	192-200	interleukin 1 alpha	Homo sapiens	75-111
19027816-6	2009	Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	139-147
19688109-4	2009	Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE(2), IL-6, and IL-8.	Prostaglandins E	106-109	interleukin 1 alpha	Homo sapiens	36-40
19139781-7	2009	Meloxicam elevates serum levels of IL-1 alpha significantly, while IL-8 did not significantly change compared to the pre-treatment value.	Meloxicam	0-9	interleukin 1 alpha	Homo sapiens	35-45
19139781-9	2009	Adjunct use of silymarin with piroxicam results in significant reduction in both cytokines (IL-1 alpha and IL-8), and serum levels of C3 and C4.	Silymarin	15-24	interleukin 1 alpha	Homo sapiens	92-102
19139781-9	2009	Adjunct use of silymarin with piroxicam results in significant reduction in both cytokines (IL-1 alpha and IL-8), and serum levels of C3 and C4.	Piroxicam	30-39	interleukin 1 alpha	Homo sapiens	92-102
19088500-3	2009	The production of IL-1alpha, CXCL10, and CCL17 and the expression of CD54 were significantly suppressed by the addition of bepotastine.	bepotastine	123-134	interleukin 1 alpha	Homo sapiens	18-27
19459427-8	2009	Losartan in both groups had an antihypertensive effect, stabilized LV hypertrophy, improved clinical symptoms leading to cytokines expression decline: TNF alpha by 9.8%, IL-1--by 6.1%, IL-6--by 6.7%.	Losartan	0-8	interleukin 1 alpha	Homo sapiens	170-174
18719352-5	2008	Exposure to curcumin led to dose-dependent suppression of osteoclastogenesis in the coculture system, and to reduced expression of RANKL in IL-1alpha-stimulated BMSCs.	Curcumin	12-20	interleukin 1 alpha	Homo sapiens	140-149
19459427-7	2009	RESULTS: Overactivation of cytokines (primarily IL-2, IL-1, TNF alpha) with high expression of IgA, IgG, CIC, AB to CL was found in CHD patients with type 2 diabetes mellitus and less evident in impaired glucose tolerance.	CHVP protocol	105-108	interleukin 1 alpha	Homo sapiens	54-58
18495501-0	2008	Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes.	Calcium	43-50	interleukin 1 alpha	Homo sapiens	0-13
18975306-10	2008	ACh significantly reduced the production of IL-6, CXCL8, CCL2, CCL3, CCL5, and granulocyte colony-stimulating factor by IL-1-stimulated FLS.	Acetylcholine	0-3	interleukin 1 alpha	Homo sapiens	120-124
18975306-12	2008	The selective alpha7R agonist PNU-282,987 decreased the production of IL-6 by IL-1-stimulated FLS.	N-neopentyl-N-nitrosourea	30-33	interleukin 1 alpha	Homo sapiens	78-82
18975307-8	2008	RESULTS: IL-1alpha caused cleavage of aggrecan in cultured human articular cartilage explants, with release of GAG and aggrecan fragments containing ARGS and AGEG neoepitopes.	Glycosaminoglycans	111-114	interleukin 1 alpha	Homo sapiens	9-18
18302264-10	2008	Exogenous HA significantly and dose-dependently decreased expression of proinflammatory cytokine mRNAs and COX-2/PGE(2) production in IL-1-stimulated SSF.	Prostaglandins E	113-116	interleukin 1 alpha	Homo sapiens	134-138
18599265-2	2008	Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upon repeated morphine exposure (tolerance).	Morphine	114-122	interleukin 1 alpha	Homo sapiens	40-53
18992573-14	2008	The expression induced by Chem-PMMA was significantly greater than the control for IL-13 (P=.036), IL-1 alpha (P=.003), IL-2 (P=.020), and IL-5 (P=.045).	chem-pmma	26-35	interleukin 1 alpha	Homo sapiens	99-109
18784253-9	2008	As a physiological activator of CREB, interleukin 1alpha triggered MEKK1-dependent phosphorylation of TORC1 and its consequent recruitment to the cAMP response elements in the interleukin 8 promoter.	Cyclic AMP	146-150	interleukin 1 alpha	Homo sapiens	38-56
18628526-0	2008	Production of interleukin-1alpha by human endometrial stromal cells is triggered during menses and dysfunctional bleeding and is induced in culture by epithelial interleukin-1alpha released upon ovarian steroids withdrawal.	Steroids	203-211	interleukin 1 alpha	Homo sapiens	14-32
18628526-0	2008	Production of interleukin-1alpha by human endometrial stromal cells is triggered during menses and dysfunctional bleeding and is induced in culture by epithelial interleukin-1alpha released upon ovarian steroids withdrawal.	Steroids	203-211	interleukin 1 alpha	Homo sapiens	162-180
18628526-2	2008	The paracrine induction of MMP-1 in stromal cells via epithelium-derived IL-1alpha is repressed by ovarian steroids.	Steroids	107-115	interleukin 1 alpha	Homo sapiens	73-82
18628526-3	2008	However, the control by estradiol (E) and progesterone (P) of endometrial IL-1alpha expression and bioactivity remains unknown.	Estradiol	24-33	interleukin 1 alpha	Homo sapiens	74-83
18628526-3	2008	However, the control by estradiol (E) and progesterone (P) of endometrial IL-1alpha expression and bioactivity remains unknown.	Progesterone	42-54	interleukin 1 alpha	Homo sapiens	74-83
18802115-5	2008	In fact, LPA alone significantly induced COX-2 expression and enhanced IL-1alpha- or IL-1beta-induced enzyme expression in a manner sensitive to pertussis toxin and Ki16425.	lysophosphatidic acid	9-12	interleukin 1 alpha	Homo sapiens	71-80
18802115-5	2008	In fact, LPA alone significantly induced COX-2 expression and enhanced IL-1alpha- or IL-1beta-induced enzyme expression in a manner sensitive to pertussis toxin and Ki16425.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	165-172	interleukin 1 alpha	Homo sapiens	71-80
18479189-7	2008	A stable knockdown of GPx2 in HT-29 cells by siRNA resulted in a high basal and IL-1-induced expression of COX-2 and mPGES-1, enzymes required for the production of the pro-inflammatory PGE(2).	Prostaglandins E	118-121	interleukin 1 alpha	Homo sapiens	80-84
18830451-1	2008	We determined the therapeutic efficacy of atractylenolide I (ATR), extracted from largehead atractylodes rhizome, in managing gastric cancer cachexia (GCC), and interpreted its probable pharmacological mechanism via investigating tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 (IL-6) and proteolysis-inducing factor (PIF).	(+)-Atractylenolide	42-57	interleukin 1 alpha	Homo sapiens	286-290
18541719-4	2008	Exposure to mf significantly down-regulated production of IFN-alpha, MIP-1alpha, IL-12p70, and IL-1alpha following activation with poly I:C, and of IL-12p40 following activation with poly I:C or LPS.	poly	131-135	interleukin 1 alpha	Homo sapiens	95-104
18541719-4	2008	Exposure to mf significantly down-regulated production of IFN-alpha, MIP-1alpha, IL-12p70, and IL-1alpha following activation with poly I:C, and of IL-12p40 following activation with poly I:C or LPS.	Poly I	131-137	interleukin 1 alpha	Homo sapiens	95-104
18729741-4	2008	Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	71-80
18928847-4	2008	We tested the hypothesis that Ca(OH)(2) denatures IL-1 alpha, TNF-alpha, and CGRP.	ca(oh)	30-36	interleukin 1 alpha	Homo sapiens	50-60
18928847-8	2008	The results indicate that Ca(OH)(2) denatures IL-1 alpha, TNF-alpha, and CGRP by 50%-100% during the testing periods (P &lt; .001).	ca(oh)	26-32	interleukin 1 alpha	Homo sapiens	46-56
18504291-8	2008	In vitro, IL-1 directly exacerbated 6-OHDA-triggered dopaminergic toxicity.	Oxidopamine	36-42	interleukin 1 alpha	Homo sapiens	10-14
18504291-9	2008	In vivo, we found that nitric oxide was a downstream molecule of IL-1 action and partially responsible for the exacerbation of neurodegeneration observed.	Nitric Oxide	23-35	interleukin 1 alpha	Homo sapiens	65-69
18302264-0	2008	Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	133-146
18302264-0	2008	Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease.	Dinoprostone	91-109	interleukin 1 alpha	Homo sapiens	133-146
18424438-8	2008	Knockdown of MEK1/2 or MSK1 expression inhibits farnesol-induced expression of CXCL3, IL-1alpha, and COX-2 mRNA.	Farnesol	48-56	interleukin 1 alpha	Homo sapiens	86-95
18424438-1	2008	In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2.	Farnesol	90-98	interleukin 1 alpha	Homo sapiens	200-209
18332138-5	2008	Inhibition of PI3K signaling using LY294002 blocked IL-1+OSM-mediated Akt phosphorylation, induction of MMP-1 and MMP-13, and cartilage collagenolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interleukin 1 alpha	Homo sapiens	52-60
18541548-8	2008	Changes in the DHA and EPA concentrations were negatively associated with changes in IL-1beta and IL-6 release for all subjects.	Docosahexaenoic Acids	15-18	interleukin 1 alpha	Homo sapiens	85-93
18541548-8	2008	Changes in the DHA and EPA concentrations were negatively associated with changes in IL-1beta and IL-6 release for all subjects.	Eicosapentaenoic Acid	23-26	interleukin 1 alpha	Homo sapiens	85-93
18541548-11	2008	CONCLUSION: AD patients treated with DHA-rich n-3 FAs supplementation increased their plasma concentrations of DHA (and EPA), which were associated with reduced release of IL-1beta, IL-6, and granulocyte colony-stimulating factor from PBMCs.	Docosahexaenoic Acids	37-40	interleukin 1 alpha	Homo sapiens	172-180
18387309-2	2008	The aim of the presented work was to analyze the mechanism of IL-1-induced cytocidal effect in HeLa cells in the presence of cycloheximide (CHX).	Cycloheximide	125-138	interleukin 1 alpha	Homo sapiens	62-66
18387309-2	2008	The aim of the presented work was to analyze the mechanism of IL-1-induced cytocidal effect in HeLa cells in the presence of cycloheximide (CHX).	Cycloheximide	140-143	interleukin 1 alpha	Homo sapiens	62-66
17467819-4	2008	METHODS AND RESULTS: hcaSMC were incubated with nebivolol or metoprolol (10(-5) mol/l) for 72 h. The downregulated genes are involved in inflammatory processes, oxidative stress and smooth muscle cell proliferation: i.e. downregulated were by nebivolol: interleukin-1alpha, cyclooxygenase-2, tumor-necrosis-factor (TNF)-alpha-induced protein 6, PDGF-A, growth-related oncogenes 2 and 3.	Nebivolol	48-57	interleukin 1 alpha	Homo sapiens	254-272
17945515-0	2008	Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.	reactive nitrogen and oxygen species	0-36	interleukin 1 alpha	Homo sapiens	40-53
17945515-1	2008	OBJECTIVE: Osteoarthritis (OA) is associated with increased levels of reactive nitrogen and oxygen species and pro-inflammatory cytokines, such as interleukin-1 (IL-1).	reactive nitrogen and oxygen species	70-106	interleukin 1 alpha	Homo sapiens	147-160
17945515-1	2008	OBJECTIVE: Osteoarthritis (OA) is associated with increased levels of reactive nitrogen and oxygen species and pro-inflammatory cytokines, such as interleukin-1 (IL-1).	reactive nitrogen and oxygen species	70-106	interleukin 1 alpha	Homo sapiens	162-166
17945515-2	2008	Nitric oxide (NO) can mediate a number of the catabolic effects of IL-1 in articular cartilage.	Nitric Oxide	0-12	interleukin 1 alpha	Homo sapiens	67-71
17945515-3	2008	The aims of this study were to determine if OA cartilage shows evidence of DNA damage, and if IL-1 could induce DNA damage in non-OA cartilage by increasing NO or superoxide.	Superoxides	163-173	interleukin 1 alpha	Homo sapiens	94-98
17945515-13	2008	CONCLUSION: Our work shows chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondrocytes in alginate.	reactive oxygen and nitrogen species	125-161	interleukin 1 alpha	Homo sapiens	97-101
17945515-13	2008	CONCLUSION: Our work shows chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondrocytes in alginate.	Alginates	188-196	interleukin 1 alpha	Homo sapiens	97-101
18471410-8	2008	The plasma levels of IL-1alpha, IL-6 and TNF-alpha in low-protein diet plus alpha-keto acid group were decreased as compared with the routine-protein diet group, but there were no significant differences.	alpha-keto acid	76-91	interleukin 1 alpha	Homo sapiens	21-30
17467819-4	2008	METHODS AND RESULTS: hcaSMC were incubated with nebivolol or metoprolol (10(-5) mol/l) for 72 h. The downregulated genes are involved in inflammatory processes, oxidative stress and smooth muscle cell proliferation: i.e. downregulated were by nebivolol: interleukin-1alpha, cyclooxygenase-2, tumor-necrosis-factor (TNF)-alpha-induced protein 6, PDGF-A, growth-related oncogenes 2 and 3.	Metoprolol	61-71	interleukin 1 alpha	Homo sapiens	254-272
17467819-5	2008	Metoprolol increased the expression of interleukin-1alpha, cyclooxygenase-1, TNF-alpha-induced protein 3, heme oxygenase 1 and granulocyte/macrophage-colony-stimulating factor.	Metoprolol	0-10	interleukin 1 alpha	Homo sapiens	39-57
18078800-7	2008	The availability of the novel assay system was demonstrated in a kinetic analysis of subtilisin-catalyzed reaction in the IL 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([Emim][Tf(2)N]) under different reaction conditions.	ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide	127-187	interleukin 1 alpha	Homo sapiens	122-126
18268213-7	2008	Additionally, ALA treatment was associated with a significant decrease in CD11b(+) cell number, expression of corneal IL-1alpha and TNF-alpha, and conjunctival TNF-alpha.	alpha-Linolenic Acid	14-17	interleukin 1 alpha	Homo sapiens	118-127
18565249-11	2008	Treatment with a selective iNOS inhibitor 1400W enhanced the production of IL-10, while the levels of MMP-10 were reduced in IL-1 -treated OA cartilage.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	42-47	interleukin 1 alpha	Homo sapiens	75-79
18292576-5	2008	SP600125 reduced the expression of the CRP gene induced by IL-1 plus IL-6.	pyrazolanthrone	0-8	interleukin 1 alpha	Homo sapiens	59-63
18292576-8	2008	SB203580 inhibited the phosphorylation of c-Fos enhanced by IL-1 plus IL-6, and diminished expression of the CRP gene.	SB 203580	0-8	interleukin 1 alpha	Homo sapiens	60-64
18403889-0	2008	Effects of interleukin-1alpha on the production and release of basic fibroblast growth factor in cultured nifedipine-reactive gingival fibroblasts.	Nifedipine	106-116	interleukin 1 alpha	Homo sapiens	11-29
18403889-8	2008	Thus, IL-1alpha increases bFGF production in nifedipine-reactive gingival fibroblasts and also influences the release of bFGF in the IL-1alpha-pretreated cells.	Nifedipine	45-55	interleukin 1 alpha	Homo sapiens	6-15
18094719-5	2008	Microarray analysis of doxycycline-induced and doxycycline-uninduced cells revealed an upregulation by ETS2 of cytokines (for example, interleukin 1 and CSF2) and transcription factors (for example, TAL1), which are key regulators of megakaryocytic differentiation.	Doxycycline	23-34	interleukin 1 alpha	Homo sapiens	135-148
18094719-5	2008	Microarray analysis of doxycycline-induced and doxycycline-uninduced cells revealed an upregulation by ETS2 of cytokines (for example, interleukin 1 and CSF2) and transcription factors (for example, TAL1), which are key regulators of megakaryocytic differentiation.	Doxycycline	47-58	interleukin 1 alpha	Homo sapiens	135-148
18557135-7	2008	We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells.	2',7'-dichlorofluorescein	82-85	interleukin 1 alpha	Homo sapiens	30-34
18557135-7	2008	We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells.	Reactive Oxygen Species	97-100	interleukin 1 alpha	Homo sapiens	30-34
18557135-7	2008	We here show that exposure to IL-1 and IL-6 significantly increased the levels of DCF-detectable ROS in cells cultured in physiologic concentrations of Mg, but not in Mg-deprived cells.	Magnesium	152-154	interleukin 1 alpha	Homo sapiens	30-34
18021073-3	2008	In the present study, we identified two IL-1-stimulated phosphorylation sites on TAB2 (Ser(372) and Ser(524)) and three on TAB3 (Ser(60), Thr(404) and Ser(506)) in human IL-1R cells [HEK-293 (human embryonic kidney) cells that stably express the IL-1 receptor] and MEFs (mouse embryonic fibroblasts).	Serine	100-103	interleukin 1 alpha	Homo sapiens	40-44
17618502-5	2008	TiAlV particles were the most stimulatory, causing 5- to 900-fold higher cytokine expression compared with nonstimulated cells and uniquely eliciting high levels of IL-1alpha, IL-6, IL-10, and GM-CSF.	tialv	0-5	interleukin 1 alpha	Homo sapiens	165-174
18021073-3	2008	In the present study, we identified two IL-1-stimulated phosphorylation sites on TAB2 (Ser(372) and Ser(524)) and three on TAB3 (Ser(60), Thr(404) and Ser(506)) in human IL-1R cells [HEK-293 (human embryonic kidney) cells that stably express the IL-1 receptor] and MEFs (mouse embryonic fibroblasts).	Serine	87-90	interleukin 1 alpha	Homo sapiens	40-44
18021073-3	2008	In the present study, we identified two IL-1-stimulated phosphorylation sites on TAB2 (Ser(372) and Ser(524)) and three on TAB3 (Ser(60), Thr(404) and Ser(506)) in human IL-1R cells [HEK-293 (human embryonic kidney) cells that stably express the IL-1 receptor] and MEFs (mouse embryonic fibroblasts).	Serine	100-103	interleukin 1 alpha	Homo sapiens	40-44
18021073-3	2008	In the present study, we identified two IL-1-stimulated phosphorylation sites on TAB2 (Ser(372) and Ser(524)) and three on TAB3 (Ser(60), Thr(404) and Ser(506)) in human IL-1R cells [HEK-293 (human embryonic kidney) cells that stably express the IL-1 receptor] and MEFs (mouse embryonic fibroblasts).	Serine	100-103	interleukin 1 alpha	Homo sapiens	40-44
18290856-7	2008	RESULTS: Hyperglycaemia reduced LPS-induced mRNA expression of nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha (NFKBIA), interleukin-1 alpha (IL1A) and chemokine (C-C motif) ligand 3 (CCL3), whereas during hyperinsulinaemia enhanced mRNA levels occurred in six out of eight measured inflammation-related genes, irrespective of plasma glucose levels.	Glucose	369-376	interleukin 1 alpha	Homo sapiens	177-181
17929310-5	2008	For glial cells, we observed that lipopolysaccharide (LPS)-induced mRNA levels of two proinflammatory genes, interleukin 1-alpha and tumor necrosis factor-alpha, are strongly decreased by treatments with resveratrol or quercetin.	Resveratrol	204-215	interleukin 1 alpha	Homo sapiens	109-160
17929310-5	2008	For glial cells, we observed that lipopolysaccharide (LPS)-induced mRNA levels of two proinflammatory genes, interleukin 1-alpha and tumor necrosis factor-alpha, are strongly decreased by treatments with resveratrol or quercetin.	Quercetin	219-228	interleukin 1 alpha	Homo sapiens	109-160
17906119-9	2008	Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), greatly augmented the IL-1 alpha promoter activity in A375-6 cells to the level comparable with that in A375-R8 cells.	trichostatin A	0-14	interleukin 1 alpha	Homo sapiens	88-98
18036576-8	2008	IL-1beta reduced tyrosine phosphorylation of the docking proteins, IRS-1 and Shc, which convey receptor activation to the downstream protein kinase cascades.	Tyrosine	17-25	interleukin 1 alpha	Homo sapiens	0-8
18252009-7	2008	RESULTS: RU inhibited inflammation-related gene expression in activated human macrophages and the release of nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 from these cells.	Rutin	9-11	interleukin 1 alpha	Homo sapiens	152-170
18047634-9	2008	Increases in release of up to approximately 4.8-, 4.3-, 4.1- and 1.8-fold were observed for IL-1a, IL-10, IL-12 and IL-8, respectively, when HUVEC were challenged with trypsin for 16 h. Agonist peptides of PAR-2, namely SLIGKV-NH2 and trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 (tc-LIGRLO-NH2), also provoked significant release of IL-8.	trans-cinnamoyl-leu-ile-gly-arg-leu-orn-nh2	235-278	interleukin 1 alpha	Homo sapiens	92-97
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	Phospholipids	105-117	interleukin 1 alpha	Homo sapiens	71-80
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	Eicosanoids	158-169	interleukin 1 alpha	Homo sapiens	71-80
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	Ceramides	171-179	interleukin 1 alpha	Homo sapiens	71-80
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	ros	185-188	interleukin 1 alpha	Homo sapiens	71-80
17981627-7	2008	TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes.	Phosphatidylcholines	122-141	interleukin 1 alpha	Homo sapiens	14-23
17981627-7	2008	TNF-alpha and IL-1alpha/beta can induce phospholipases (A2, C, and D) and sphingomyelinases, and concomitantly proteolyse phosphatidylcholine and sphingomyelin synthesizing enzymes.	Sphingomyelins	74-87	interleukin 1 alpha	Homo sapiens	14-23
17981627-8	2008	Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling.	Phosphatidylcholines	50-69	interleukin 1 alpha	Homo sapiens	151-160
18085494-4	2008	Prolonged IL-1alpha treatment for 12 to 24 hours partially decreased the protein levels as well as the insulin-stimulated tyrosine phosphorylation of IRS-1 and Akt phosphorylation.	Tyrosine	122-130	interleukin 1 alpha	Homo sapiens	10-19
17965029-6	2008	A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha.	besifloxacin	35-47	interleukin 1 alpha	Homo sapiens	77-86
18171484-2	2008	Integrating these data suggests that GABA may play a role in downregulating mechanisms that lead to the production of proinflammatory agents such as interleukin-1, interleukin-6, and matrix metalloproteinase 3 - agents implicated in the pathogenesis of rheumatoid arthritis (RA).	gamma-Aminobutyric Acid	37-41	interleukin 1 alpha	Homo sapiens	149-162
18047634-9	2008	Increases in release of up to approximately 4.8-, 4.3-, 4.1- and 1.8-fold were observed for IL-1a, IL-10, IL-12 and IL-8, respectively, when HUVEC were challenged with trypsin for 16 h. Agonist peptides of PAR-2, namely SLIGKV-NH2 and trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 (tc-LIGRLO-NH2), also provoked significant release of IL-8.	tc-ligrlo-nh2	280-293	interleukin 1 alpha	Homo sapiens	92-97
17981627-8	2008	Together, these alterations contribute to loss of phosphatidylcholine and sphingomyelin after stroke that can be attenuated by inhibiting TNF-alpha or IL-1alpha/beta signaling.	Sphingomyelins	74-87	interleukin 1 alpha	Homo sapiens	151-160
18068103-2	2008	A selective inhibitor of ERK1/2 pathway, PD98059 and a selective inhibitor of p38MAPK, SB203580 each alone significantly reversed the IL-1-induced growth inhibition of A375-6 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	41-48	interleukin 1 alpha	Homo sapiens	134-138
18068103-2	2008	A selective inhibitor of ERK1/2 pathway, PD98059 and a selective inhibitor of p38MAPK, SB203580 each alone significantly reversed the IL-1-induced growth inhibition of A375-6 cells.	SB 203580	87-95	interleukin 1 alpha	Homo sapiens	134-138
18068103-3	2008	Co-treatment with PD98059 and SB203580 completely reversed the IL-1-induced growth inhibition.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	interleukin 1 alpha	Homo sapiens	63-67
18068103-3	2008	Co-treatment with PD98059 and SB203580 completely reversed the IL-1-induced growth inhibition.	SB 203580	30-38	interleukin 1 alpha	Homo sapiens	63-67
18068103-7	2008	These effects of IL-1 were reversed by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	39-46	interleukin 1 alpha	Homo sapiens	17-21
18068103-8	2008	PD98059 also reversed the IL-1-induced hypophosphorylation of RB protein (pRB) and down-regulation of E2F activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 alpha	Homo sapiens	26-30
17906119-9	2008	Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), greatly augmented the IL-1 alpha promoter activity in A375-6 cells to the level comparable with that in A375-R8 cells.	trichostatin A	16-19	interleukin 1 alpha	Homo sapiens	88-98
17906119-10	2008	TSA also induced IL-1 alpha mRNA expression in A375-6 cells.	trichostatin A	0-3	interleukin 1 alpha	Homo sapiens	17-27
18751914-5	2008	TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders.	Eicosanoids	70-81	interleukin 1 alpha	Homo sapiens	14-18
18188710-6	2008	Some inhibitory cytokines, such as tumour necrosis factor-alpha and interleukin-1, act on the suppression of erythroid precursor cells and erythropoietic production and response; others, such as interleukins 1 and 6 and hepcidin, impair iron metabolism, causing iron to be diverted from erythropoiesis and retained within the reticuloendothelial system.	Iron	237-241	interleukin 1 alpha	Homo sapiens	68-81
18188710-6	2008	Some inhibitory cytokines, such as tumour necrosis factor-alpha and interleukin-1, act on the suppression of erythroid precursor cells and erythropoietic production and response; others, such as interleukins 1 and 6 and hepcidin, impair iron metabolism, causing iron to be diverted from erythropoiesis and retained within the reticuloendothelial system.	Iron	262-266	interleukin 1 alpha	Homo sapiens	68-81
19001760-3	2008	The fungal elements beta-D-glucan and trichophytin from Trichophyton rubrum and Trichophyton mentagrophytes augmented production of IL-8 and IL-1 alpha of cultured normal human epidermal keratinocytes.	maltotriose	20-33	interleukin 1 alpha	Homo sapiens	141-151
19001760-5	2008	Next we examined the effect of liranaftate, a representative Japanese thiocarbamate antifungal agent, on the production of IL-8 and IL-1 alpha.	liranaftate	31-42	interleukin 1 alpha	Homo sapiens	132-142
19112497-7	2008	Furthermore, lysine-deficient TRAF6 rescued IL-1-mediated NFkappaB and MAPK activation, as well as IL-6 elaboration in retrovirally-rescued TRAF6-deficient fibroblasts.	Lysine	13-19	interleukin 1 alpha	Homo sapiens	44-48
18751914-5	2008	TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders.	Ceramides	83-91	interleukin 1 alpha	Homo sapiens	14-18
18751914-5	2008	TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders.	reactive oxygen	97-112	interleukin 1 alpha	Homo sapiens	14-18
18049445-4	2007	The "cholinergic anti-inflammatory pathway" mediated by acetylcholine acts by inhibiting the production of tumor necrosis factor, interleukin-1, macrophage migration inhibitory factor, and high mobility group box-1 and suppresses the activation of nuclear factor-kappa B expression.	Acetylcholine	56-69	interleukin 1 alpha	Homo sapiens	130-143
17561366-3	2007	IL-1 plays a role in the synthesis, degradation and degree of sulphatation of ECM components such as glycosaminoglycans.	Glycosaminoglycans	101-119	interleukin 1 alpha	Homo sapiens	0-4
17561366-12	2007	IL-1 acts on osteoblasts with decreases in GAG synthesis and alkaline phosphatase activity, while beta-NAG increases.	Glycosaminoglycans	43-46	interleukin 1 alpha	Homo sapiens	0-4
17956473-8	2007	Interleukin-1 and oncostatin M produced a significant increase in the up-regulation of MMP-1, which was reversed when cyclosporin and nifedipine were added to the cell cultures (p &lt; 0.05).	Cyclosporine	118-129	interleukin 1 alpha	Homo sapiens	0-13
17956473-8	2007	Interleukin-1 and oncostatin M produced a significant increase in the up-regulation of MMP-1, which was reversed when cyclosporin and nifedipine were added to the cell cultures (p &lt; 0.05).	Nifedipine	134-144	interleukin 1 alpha	Homo sapiens	0-13
19143193-9	2008	RESULTS: A dominating hyperactivation of cytokines TNFalpha, IL-1alpha, IL-2, IL-6 with high expression of CIC and autoAB to CL was associated with moderate or severe CCF (FCII-IV by NYHA), declined inotropic function of the left ventricle (EF 38-23%), low exercise tolerance and remodeling of the left ventricle.	cic	107-110	interleukin 1 alpha	Homo sapiens	61-70
18210237-2	2007	Costunolide has been reported to inhibit IL-1 production, but whether other cytokines could be inhibited remains to be confirmed.	costunolide	0-11	interleukin 1 alpha	Homo sapiens	41-45
18167453-2	2007	COS (0.1-5mg/ ml) suppressed the NO production induced by proinflammatory cytokines (100 U/ml IFN-gamma, 10 ng/ml IL-1alpha, and 25 ng/ml TNF-alpha) in HT-29 cells.	carbonyl sulfide	0-3	interleukin 1 alpha	Homo sapiens	114-123
17549071-4	2007	Bacteria may also regulate AMP expression by inducing keratinocyte expression of the autonomous proinflammatory cytokine, interleukin-1alpha (IL-1alpha).	Adenosine Monophosphate	27-30	interleukin 1 alpha	Homo sapiens	122-140
17959901-4	2007	Stimulation of gingival fibroblasts with tumor necrosis factor-alpha, IL-1alpha, and lipopolysaccharide markedly induced IL-8 production, and the IL-8 production was synergistically augmented in the presence of or pre-treatment with histamine.	Histamine	233-242	interleukin 1 alpha	Homo sapiens	70-79
17640979-2	2007	IL-1, a key cytokine associated with intestinal mucosal inflammation, induces COX-2 expression in human colonic myofibroblasts (CMF) and increased prostaglandin E(2) secretion is associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC).	Dinoprostone	147-165	interleukin 1 alpha	Homo sapiens	0-4
17640979-8	2007	We found that HETEs enhanced IL-1-induced COX-2 mRNA levels in CMF as the result of increased p38, MK-2, and HuR activity, increasing message stability greater than that observed with IL-1 alone.	Hydroxyeicosatetraenoic Acids	14-19	interleukin 1 alpha	Homo sapiens	29-33
17640979-8	2007	We found that HETEs enhanced IL-1-induced COX-2 mRNA levels in CMF as the result of increased p38, MK-2, and HuR activity, increasing message stability greater than that observed with IL-1 alone.	Hydroxyeicosatetraenoic Acids	14-19	interleukin 1 alpha	Homo sapiens	184-188
17996095-3	2007	In previous studies, F3, the active component of the polysaccharide extract, was found to activate various cytokines such as IL-1, IL-6, IL-12, and TNF-alpha.	Polysaccharides	53-67	interleukin 1 alpha	Homo sapiens	125-129
17549071-4	2007	Bacteria may also regulate AMP expression by inducing keratinocyte expression of the autonomous proinflammatory cytokine, interleukin-1alpha (IL-1alpha).	Adenosine Monophosphate	27-30	interleukin 1 alpha	Homo sapiens	142-151
17549071-5	2007	To test the hypothesis that AMP expression may be regulated by cell autonomous cytokines, we investigated the effect of IL-1alpha on the expression of AMPs in human keratinocytes (HaCaT cells) by microarray, northern blot, reverse transcriptase (RT)-PCR and western blot analyses.	Adenylyl sulfate	151-155	interleukin 1 alpha	Homo sapiens	120-129
17549071-9	2007	These results suggest that the autonomous keratinocyte cytokine, IL-1alpha, selectively upregulates the expression of AMPs which may modulate innate epithelial cell immunity in skin and mucosa.	Adenylyl sulfate	118-122	interleukin 1 alpha	Homo sapiens	65-74
17785828-3	2007	Costimulation of mo-DCs with NadADelta351-405 and the imidoazoquinoline drug R-848, believed to mimic bacterial RNA, increased CD86 in an additive way, but strongly synergized the secretion of IL-12p70, IL-1, IL-6, TNF-alpha, and MIP-1alpha, especially after IFN-gamma priming.	nadadelta351	29-41	interleukin 1 alpha	Homo sapiens	193-197
16600299-4	2007	By analysis of covariance (adjustment for age, gender, coronary heart disease, diabetes, hypertension, smoking, and alcohol consumption) we found that: *IL-1beta was higher in VD, LOAD, and CDND compared with controls (p<0.005).	Alcohols	116-123	interleukin 1 alpha	Homo sapiens	153-161
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	6-9	interleukin 1 alpha	Homo sapiens	81-100
17717316-9	2007	GSTO1 Asp/Asp carriers showed larger areas of atherosclerosis plaques containing interleukin-1 alpha-positive material than carriers of the GSTO1 Ala-allele.	Aspartic Acid	10-13	interleukin 1 alpha	Homo sapiens	81-100
18219763-6	2007	IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-kappaB and mitogen-activated protein kinase (p-38), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2.	Dinoprostone	281-297	interleukin 1 alpha	Homo sapiens	0-4
17763411-0	2007	Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations.	Adenosine Triphosphate	77-80	interleukin 1 alpha	Homo sapiens	11-24
17449468-5	2007	The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively.	Lysine	61-64	interleukin 1 alpha	Homo sapiens	228-232
17618910-5	2007	Results of the steady-state fluorescence and 2D NMR experiments show that the recombinant IL-1alpha is in a folded conformation.	Echothiophate Iodide	45-47	interleukin 1 alpha	Homo sapiens	90-99
17618910-7	2007	Isothermal titration calorimetry (ITC) experiments show that the recombinant IL-1alpha binds strongly (K(d) approximately 5.6 x 10(-7) M) to S100A13, a calcium binding protein that chaperones the in vivo release of IL-1alpha into the extracellular compartment.	Calcium	152-159	interleukin 1 alpha	Homo sapiens	77-86
17907487-6	2007	Amplification of the IL-1A gene by PCR was carried out using the purified DNAs and electrophoresing on polyacrylamide gel.	polyacrylamide	103-117	interleukin 1 alpha	Homo sapiens	21-26
17502394-6	2007	In contrast, vaccination with JBCG resulted in significantly greater expression of cytokines characteristic of a proinflammatory immune response (IL-1alpha, IL-1beta, IL-6, and IL-24) in PBMC activated with CFP compared to PBMC from children vaccinated with BBCG or DBCG.	jbcg	30-34	interleukin 1 alpha	Homo sapiens	146-155
17630143-4	2007	STUDY DESIGN: A short-term in vitro study using normal and interleukin (IL)-1alpha stimulated porcine disc cells cultured in alginate gel to evaluate the biochemical effects of electrosurgical ablation.	Alginates	125-133	interleukin 1 alpha	Homo sapiens	59-82
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	Ethanol	216-223	interleukin 1 alpha	Homo sapiens	59-82
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	Ethanol	225-229	interleukin 1 alpha	Homo sapiens	59-82
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	Acetyl-L-carnitine hydrochloride	305-308	interleukin 1 alpha	Homo sapiens	59-82
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	alcet	352-357	interleukin 1 alpha	Homo sapiens	59-82
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	Alcohols	172-179	interleukin 1 alpha	Homo sapiens	59-82
17368827-6	2007	Results showed that hexavalent chromium was significantly more cytotoxic, associated more with keratinocytes and induced a dose dependant release of IL-1alpha compared to nickel.	Chromium	31-39	interleukin 1 alpha	Homo sapiens	149-158
17112620-8	2007	1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties.	Calcitriol	0-26	interleukin 1 alpha	Homo sapiens	88-92
17340198-0	2007	Structural differences between the putative carbohydrate-recognition domains of human IL-1 alpha, IL-1 beta and IL-1 receptor antagonist obtained by in silico modeling.	Carbohydrates	44-56	interleukin 1 alpha	Homo sapiens	86-96
17340198-2	2007	J Biol Chem 276 (2001) 5685-5691), it was established that biologically active recombinant human IL-1alpha and IL-1beta had different carbohydrate-binding properties.	Carbohydrates	134-146	interleukin 1 alpha	Homo sapiens	97-106
17340198-3	2007	IL-1alpha recognized a di-antennary N-glycan with two alpha2-3-linked sialic acid residues, whereas IL-1beta recognized the GM(4), a alpha2-3-linked sialylated glycosphingolipid.	n-glycan	36-44	interleukin 1 alpha	Homo sapiens	0-9
17591882-8	2007	The p38 MAP kinase inhibitor SB202190 diminished MMP-3 induction by TNFalpha at all times and at 24 hours by IL-1alpha but potentiated the IL-1alpha-induced increase in MMP-3 at later times.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	29-37	interleukin 1 alpha	Homo sapiens	109-118
17591882-8	2007	The p38 MAP kinase inhibitor SB202190 diminished MMP-3 induction by TNFalpha at all times and at 24 hours by IL-1alpha but potentiated the IL-1alpha-induced increase in MMP-3 at later times.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	29-37	interleukin 1 alpha	Homo sapiens	139-148
17478472-1	2007	OBJECTIVE: New treatments that inhibit the cytokines tumour necrosis factor alpha (TNFalpha) and interleukin 1 (IL-1) in the treatment of rheumatoid arthritis have proven clinical effect against placebo and methotrexate (MTX) in several clinical trials in early and late-stage disease and different severity groups.	Methotrexate	207-219	interleukin 1 alpha	Homo sapiens	97-116
17478472-1	2007	OBJECTIVE: New treatments that inhibit the cytokines tumour necrosis factor alpha (TNFalpha) and interleukin 1 (IL-1) in the treatment of rheumatoid arthritis have proven clinical effect against placebo and methotrexate (MTX) in several clinical trials in early and late-stage disease and different severity groups.	Methotrexate	221-224	interleukin 1 alpha	Homo sapiens	97-116
17478472-11	2007	CONCLUSION: When the outcome of interest is the probability of an ACR20 or ACR50 response at 6 months we found: (i) treatment with the IL-1 antagonist anakinra is better than placebo; (ii) for each treatment, the use of combination MTX improves the probability of response; (iii) treatment with any of the TNFalpha antagonists is better than with the IL-1 antagonist anakinra; and (iv) all drugs in the TNFalpha antagonist class are no different from each other.	Methotrexate	232-235	interleukin 1 alpha	Homo sapiens	135-139
17293495-5	2007	Knockdown of IL-1 alpha abolished TLR-induced proliferation and suppressed TLR4-induced release of monocyte chemoattractant protein-1 (MCP-1) by VSMC, indicating that endogenous IL-1 alpha plays a crucial role in both responses.	vsmc	145-149	interleukin 1 alpha	Homo sapiens	13-23
17293495-5	2007	Knockdown of IL-1 alpha abolished TLR-induced proliferation and suppressed TLR4-induced release of monocyte chemoattractant protein-1 (MCP-1) by VSMC, indicating that endogenous IL-1 alpha plays a crucial role in both responses.	vsmc	145-149	interleukin 1 alpha	Homo sapiens	178-188
17541168-0	2007	Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.	Dihydrotestosterone	0-19	interleukin 1 alpha	Homo sapiens	65-83
17414629-12	2007	Docetaxel in combination with leucovorin, 5-fluorouracil and capecitabine followed by low-dose interleukin 1-2 and 13-cis-retinoic acid is well tolerated, and shows a significant activity in patients with metastatic gastric adenocarcinoma.	Docetaxel	0-9	interleukin 1 alpha	Homo sapiens	95-110
17541168-4	2007	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF).	Dihydrotestosterone	129-132	interleukin 1 alpha	Homo sapiens	75-84
17541168-4	2007	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF).	Dihydrotestosterone	33-59	interleukin 1 alpha	Homo sapiens	75-84
17541168-4	2007	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF).	Dihydrotestosterone	61-64	interleukin 1 alpha	Homo sapiens	75-84
17541168-4	2007	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF).	hydroxyflutamide	190-206	interleukin 1 alpha	Homo sapiens	75-84
17509446-8	2007	When PBMC were cultured with a2NTD, there was a 2.5-fold increase in IL1A and IL1B gene expression and no induction of TNF gene expression.	a2ntd	29-34	interleukin 1 alpha	Homo sapiens	69-73
17541168-4	2007	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF).	ohf	208-211	interleukin 1 alpha	Homo sapiens	75-84
17541168-6	2007	These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease.	Dihydrotestosterone	27-30	interleukin 1 alpha	Homo sapiens	61-70
17440718-8	2007	Calpain required a 100-fold higher concentration to process the pre-IL-1alpha containing Ala at the 114th amino acid than that to do containing Ser.	Alanine	89-92	interleukin 1 alpha	Homo sapiens	68-77
17440718-11	2007	Pre-IL-1alpha with Ala, which was high in frequency in SSc patients, was more resistant to be cleaved by proteases in human sera than pro-IL-1alpha with Ser.	Alanine	19-22	interleukin 1 alpha	Homo sapiens	4-13
17440718-11	2007	Pre-IL-1alpha with Ala, which was high in frequency in SSc patients, was more resistant to be cleaved by proteases in human sera than pro-IL-1alpha with Ser.	Serine	153-156	interleukin 1 alpha	Homo sapiens	138-147
17388412-1	2007	Steady-state and time-resolved infrared spectroscopy of the azide (N(3)-) anion has been used to characterize aqueous mixtures both with the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF(4)]) and with dimethyl sulfoxide (DMSO).	Azides	60-65	interleukin 1 alpha	Homo sapiens	141-160
17388412-1	2007	Steady-state and time-resolved infrared spectroscopy of the azide (N(3)-) anion has been used to characterize aqueous mixtures both with the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF(4)]) and with dimethyl sulfoxide (DMSO).	n(3)-) anion	67-79	interleukin 1 alpha	Homo sapiens	141-160
17466923-10	2007	In addition, T-helper cell 1 cytokines [TNF-alpha, interleukins (ILs) 1 and 2] as well as the chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) control the pathogenesis of sulfonamide-induced HSR and may be used in early diagnosis of the syndrome.	Sulfonamides	205-216	interleukin 1 alpha	Homo sapiens	51-77
17224841-4	2007	Polymethylmethacrylate elicited a six- to 12-fold increase in gene expression of tumor necrosis factor alpha, interleukin 1alpha, interleukin 1beta, interleukin 6, and interleukin 8 in purified monocytes and unfractionated peripheral blood mononuclear cells.	Polymethyl Methacrylate	0-22	interleukin 1 alpha	Homo sapiens	110-128
17395016-3	2007	We found that a prolonged exposure of alveolar macrophages to a nonlethal dose (8 microg/ml) of JP-8, the kerosene-based hydrocarbon jet fuel, induced the persistent expression of IL-1, iNOS, and COX-2, as well as cell adhesion molecules (ICAM-1 and VCAM-1).	Hydrocarbons	121-132	interleukin 1 alpha	Homo sapiens	180-184
17404114-5	2007	RESULTS: We showed by DNA-binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1, and H(2)O(2) was suppressed by morin; the suppression was not cell type specific.	Ceramides	159-167	interleukin 1 alpha	Homo sapiens	169-182
17458594-15	2007	Administration of L-arginine and aprotinin led to suppression of the release of TNF-alpha, IL-1, and IL-6 during reperfusion in a statistically significant manner (all p &lt; 0.05).	Arginine	18-28	interleukin 1 alpha	Homo sapiens	91-95
17417942-4	2007	While NaBu significantly increased the IL-1beta -induction of genes like SAA2, C3, and IL-1alpha , other inflammatory genes like CXCL5, CXCL11, and IL-1beta were decreased.	sethoxydim	6-10	interleukin 1 alpha	Homo sapiens	87-96
17312152-0	2007	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha.	Estradiol	0-16	interleukin 1 alpha	Homo sapiens	25-34
17312152-3	2007	In this study we examined whether 17beta-estradiol (E2) induced IL-1alpha mRNA expression in the rheumatoid fibroblast-like cell line MH7A, as well as in primary synovial cells from RA patients, and investigated the underlying molecular mechanisms.	Estradiol	34-50	interleukin 1 alpha	Homo sapiens	64-73
17624241-0	2007	Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha.	Tannins	0-11	interleukin 1 alpha	Homo sapiens	63-72
17624241-11	2007	A blocking study using anti IL-1 alpha and anti TNF-alpha antibodies showed a reduction in TA-induced acantholysis.	Tannins	91-93	interleukin 1 alpha	Homo sapiens	28-38
17371964-0	2007	Prostaglandin E2 induces the expression of IL-1alpha in colon cancer cells.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	43-52
17371964-2	2007	In the present study, we demonstrate that PGE(2) induced the expression of IL-1alpha in colon cancer cells, which plays critical roles in tumor metastasis and neoangiogenesis in a variety of cancers.	Prostaglandins E	42-45	interleukin 1 alpha	Homo sapiens	75-84
17371964-3	2007	PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling.	Prostaglandins E	0-3	interleukin 1 alpha	Homo sapiens	36-45
17371964-3	2007	PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling.	Prostaglandins E	0-3	interleukin 1 alpha	Homo sapiens	36-40
17371964-3	2007	PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling.	Prostaglandins E	129-132	interleukin 1 alpha	Homo sapiens	36-45
17371964-3	2007	PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling.	Prostaglandins E	129-132	interleukin 1 alpha	Homo sapiens	36-40
17371964-4	2007	Mechanistically, PGE(2) induced the expression of IL-1alpha at both transcriptional and posttranscriptional levels.	Prostaglandins E	17-20	interleukin 1 alpha	Homo sapiens	50-59
17371964-5	2007	PGE(2) stimulated the transcriptional activity of the IL-1alpha promoter and significantly stabilized IL-1alpha mRNA.	Dinoprostone	0-6	interleukin 1 alpha	Homo sapiens	54-63
17371964-5	2007	PGE(2) stimulated the transcriptional activity of the IL-1alpha promoter and significantly stabilized IL-1alpha mRNA.	Dinoprostone	0-6	interleukin 1 alpha	Homo sapiens	102-111
17371964-8	2007	Thus, our results suggest that PGE(2) induces the expression of proinflammatory cytokine IL-1alpha, which may potentially enhance the proneoplastic actions of the cyclooxygenase-2/PGE(2) signaling pathway.	Prostaglandins E	31-34	interleukin 1 alpha	Homo sapiens	89-98
17371964-8	2007	Thus, our results suggest that PGE(2) induces the expression of proinflammatory cytokine IL-1alpha, which may potentially enhance the proneoplastic actions of the cyclooxygenase-2/PGE(2) signaling pathway.	Prostaglandins E	180-183	interleukin 1 alpha	Homo sapiens	89-98
17299153-9	2007	Incubation with captopril (500-1000 micromol/L), enalapril (100-1000 micromol/L), and losartan (1-100 micromol/L) significantly decreased inflammatory mediator (TNF-alpha, IL-1alpha)-induced mesothelial VEGF overproduction.	Captopril	16-25	interleukin 1 alpha	Homo sapiens	172-181
17299153-9	2007	Incubation with captopril (500-1000 micromol/L), enalapril (100-1000 micromol/L), and losartan (1-100 micromol/L) significantly decreased inflammatory mediator (TNF-alpha, IL-1alpha)-induced mesothelial VEGF overproduction.	Enalapril	49-58	interleukin 1 alpha	Homo sapiens	172-181
17299153-9	2007	Incubation with captopril (500-1000 micromol/L), enalapril (100-1000 micromol/L), and losartan (1-100 micromol/L) significantly decreased inflammatory mediator (TNF-alpha, IL-1alpha)-induced mesothelial VEGF overproduction.	Losartan	86-94	interleukin 1 alpha	Homo sapiens	172-181
17319946-6	2007	IL-1 induced binding of nuclear extract to the putative composite PPRE/AP-1 site was diminished in the presence of pioglitazone, but there was no evidence of any change in the composition of the retarded complexes, and no evidence of PPARgamma binding to this site.	Pioglitazone	115-127	interleukin 1 alpha	Homo sapiens	0-4
17257626-3	2007	The effects of thymine and cytosine on transcriptional activity of the interleukin-1A promoter were analyzed by testing luciferase-reporter activity in transfected SVG cells.	Thymine	15-22	interleukin 1 alpha	Homo sapiens	71-85
17257626-3	2007	The effects of thymine and cytosine on transcriptional activity of the interleukin-1A promoter were analyzed by testing luciferase-reporter activity in transfected SVG cells.	Cytosine	27-35	interleukin 1 alpha	Homo sapiens	71-85
17257626-4	2007	Our results demonstrate that cytosine/thymine conversion increases activity of the interleukin-1A promoter in SVG cells.	Cytosine	29-37	interleukin 1 alpha	Homo sapiens	83-97
17257626-4	2007	Our results demonstrate that cytosine/thymine conversion increases activity of the interleukin-1A promoter in SVG cells.	Thymine	38-45	interleukin 1 alpha	Homo sapiens	83-97
17319946-7	2007	Nordihydroguaiaretic acid (NDGA), a non-selective lipoxygenase inhibitor, and MK886, a specific inhibitor of 5-lipoxygenase, induced MMP-3 expression synergistically with IL-1.	Masoprocol	0-25	interleukin 1 alpha	Homo sapiens	171-175
17319946-7	2007	Nordihydroguaiaretic acid (NDGA), a non-selective lipoxygenase inhibitor, and MK886, a specific inhibitor of 5-lipoxygenase, induced MMP-3 expression synergistically with IL-1.	Masoprocol	27-31	interleukin 1 alpha	Homo sapiens	171-175
17319946-7	2007	Nordihydroguaiaretic acid (NDGA), a non-selective lipoxygenase inhibitor, and MK886, a specific inhibitor of 5-lipoxygenase, induced MMP-3 expression synergistically with IL-1.	MK-886	78-83	interleukin 1 alpha	Homo sapiens	171-175
17295437-11	2007	IL-1 decreased both proteoglycan and collagen II synthesis in cartilage explants in 1% O2 or 20% O2, but MnTE-2-PyP5+ did not prevent these anti-anabolic effects.	Oxygen	87-89	interleukin 1 alpha	Homo sapiens	0-4
17257091-7	2007	However, the activity of glucosamine sulfate has recently been related to its capacity to downregulate the catabolic effects of pro-inflammatory molecules, such as IL-1, which are present in osteoarthritic cartilage.	Glucosamine	25-44	interleukin 1 alpha	Homo sapiens	164-168
17295437-0	2007	Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.	Oxygen	13-19	interleukin 1 alpha	Homo sapiens	31-44
17114176-7	2007	The addition of fosfomycin significantly inhibited mRNA levels of pro-inflammatory cytokines such as IL-1-alpha, IL-6 and TNF-alpha after 2 h (P &lt; 0.01), while no significant reduction was observed for the anti-inflammatory cytokines IL-4, IL-10 and IL-13 (P = 0.26).	Fosfomycin	16-26	interleukin 1 alpha	Homo sapiens	101-111
17251521-1	2007	Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts.	Dinoprostone	59-77	interleukin 1 alpha	Homo sapiens	0-18
17251521-1	2007	Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts.	Dinoprostone	59-77	interleukin 1 alpha	Homo sapiens	19-28
17251521-1	2007	Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts.	Prostaglandins E	79-82	interleukin 1 alpha	Homo sapiens	0-18
17251521-1	2007	Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts.	Prostaglandins E	79-82	interleukin 1 alpha	Homo sapiens	19-28
17251521-4	2007	IL-1alphaincreased the expression of COX-2 mRNA and protein, and PGE(2) secretion in the fibroblasts.	Dinoprostone	65-71	interleukin 1 alpha	Homo sapiens	0-4
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	58-67
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	58-67
17214633-8	2007	RA inhibited the expression of S100A8/A9 and keratinocyte differentiation, which were induced by interleukin-1alpha.	Radium	0-2	interleukin 1 alpha	Homo sapiens	97-115
17295437-0	2007	Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.	Peroxynitrous Acid	53-66	interleukin 1 alpha	Homo sapiens	31-44
17295437-11	2007	IL-1 decreased both proteoglycan and collagen II synthesis in cartilage explants in 1% O2 or 20% O2, but MnTE-2-PyP5+ did not prevent these anti-anabolic effects.	Oxygen	97-99	interleukin 1 alpha	Homo sapiens	0-4
17295437-4	2007	We investigated whether oxygen tension influences the effects of interleukin 1 (IL-1) on peroxynitrite formation and cartilage matrix metabolism.	Peroxynitrous Acid	89-102	interleukin 1 alpha	Homo sapiens	65-84
17295437-13	2007	CONCLUSION: Our findings show that oxygen tension alters IL-1-induced peroxynitrite formation, which can influence proteoglycan degradation.	Oxygen	35-41	interleukin 1 alpha	Homo sapiens	57-61
17295437-8	2007	RESULTS: IL-1-induced peroxynitrite formation was decreased in 1% O2 as compared to 20% O2.	Peroxynitrous Acid	22-35	interleukin 1 alpha	Homo sapiens	9-13
17295437-8	2007	RESULTS: IL-1-induced peroxynitrite formation was decreased in 1% O2 as compared to 20% O2.	Oxygen	66-68	interleukin 1 alpha	Homo sapiens	9-13
17295437-8	2007	RESULTS: IL-1-induced peroxynitrite formation was decreased in 1% O2 as compared to 20% O2.	Oxygen	88-90	interleukin 1 alpha	Homo sapiens	9-13
17295437-9	2007	MnTE-2-PyP5+ inhibited IL-1-induced peroxynitrite formation in either 1% O2 or 20% O2.	Peroxynitrous Acid	36-49	interleukin 1 alpha	Homo sapiens	23-27
17295437-9	2007	MnTE-2-PyP5+ inhibited IL-1-induced peroxynitrite formation in either 1% O2 or 20% O2.	Oxygen	73-75	interleukin 1 alpha	Homo sapiens	23-27
17295437-9	2007	MnTE-2-PyP5+ inhibited IL-1-induced peroxynitrite formation in either 1% O2 or 20% O2.	Oxygen	83-85	interleukin 1 alpha	Homo sapiens	23-27
17295437-10	2007	In 1% O2 (but not in 20% O2), Mn porphyrin significantly inhibited IL-1-induced proteoglycan degradation.	Oxygen	6-8	interleukin 1 alpha	Homo sapiens	67-71
17295437-13	2007	CONCLUSION: Our findings show that oxygen tension alters IL-1-induced peroxynitrite formation, which can influence proteoglycan degradation.	Peroxynitrous Acid	70-83	interleukin 1 alpha	Homo sapiens	57-61
17295437-10	2007	In 1% O2 (but not in 20% O2), Mn porphyrin significantly inhibited IL-1-induced proteoglycan degradation.	mn porphyrin	30-42	interleukin 1 alpha	Homo sapiens	67-71
17241078-1	2007	The long-chain ionic liquid (IL) 1-hexadecyl-3-methylimidazolium chloride (C(16)mimCl) was used as a template to prepare porous silica with a two-dimensional hexagonal p6mm mesopore structure (MCM-41-type) as well as with a cubic Ia3d (gyroid, MCM-48-type structure) framework in basic synthesis medium via a hydrothermal synthesis procedure.	hexadecyl-3-methylimidazolium chloride	35-73	interleukin 1 alpha	Homo sapiens	15-34
17241078-1	2007	The long-chain ionic liquid (IL) 1-hexadecyl-3-methylimidazolium chloride (C(16)mimCl) was used as a template to prepare porous silica with a two-dimensional hexagonal p6mm mesopore structure (MCM-41-type) as well as with a cubic Ia3d (gyroid, MCM-48-type structure) framework in basic synthesis medium via a hydrothermal synthesis procedure.	Silicon Dioxide	128-134	interleukin 1 alpha	Homo sapiens	15-34
17189875-6	2007	Proinflammatory cytokines such as interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) also stimulated NF-kappaB-dependent transcription and showed an additive effect with high glucose.	Glucose	182-189	interleukin 1 alpha	Homo sapiens	34-79
17070781-6	2007	Atorvastatin also downregulated interleukin-1alpha (IL-1alpha)-induced OPG production in endothelial cells.	Atorvastatin	0-12	interleukin 1 alpha	Homo sapiens	32-50
17070781-6	2007	Atorvastatin also downregulated interleukin-1alpha (IL-1alpha)-induced OPG production in endothelial cells.	Atorvastatin	0-12	interleukin 1 alpha	Homo sapiens	52-61
17417984-6	2007	Celecoxib increased interleukin-1 (IL-1)-induced production of RANTES and MIP-1alpha by chondrocytes and decreased IL-1-induced NO production by chondrocytes, whereas it did not affect MMP production.	Celecoxib	0-9	interleukin 1 alpha	Homo sapiens	20-39
16636934-0	2007	T-889C IL-1alpha promoter polymorphism influences the response to oral cyclophosphamide in scleroderma patients with alveolitis.	Cyclophosphamide	71-87	interleukin 1 alpha	Homo sapiens	7-16
16927387-10	2007	Secretion of MMP-3 was also suppressed by AjA in both TNFalpha- and IL-1alpha-stimulated PPARgamma+/- and PPARgamma-/- MEF.	lenabasum	42-45	interleukin 1 alpha	Homo sapiens	68-77
17030099-7	2007	Furthermore, ghrelin inhibits pro-inflammatory cytokines such as IL-1alpha, IL-1beta, TNF-alpha which may cause oral mucositis and aneroxia, which are the results of weight loss.	Ghrelin	13-20	interleukin 1 alpha	Homo sapiens	65-74
18958713-2	2007	Exposure of AM to JP-8 for 24 hr exhibited release of IL-1alpha,beta, whereas exposure to AIIE showed a concentration-dependent NO overproduction.	JP-8	18-22	interleukin 1 alpha	Homo sapiens	54-63
18958713-4	2007	However, treatment with substance P significantly attenuated JP-8 induced the IL-1alpha,beta secretion.	JP-8	61-65	interleukin 1 alpha	Homo sapiens	78-87
16868182-0	2007	Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages.	geldanamycin	0-12	interleukin 1 alpha	Homo sapiens	98-111
16868182-1	2007	We have demonstrated that lipopolysaccharide (LPS)-mediated reactive oxygen species (ROS) and signal transduction are involved in the regulation of interleukin-1 (IL-1) beta gene expression within macrophages.	Reactive Oxygen Species	60-83	interleukin 1 alpha	Homo sapiens	148-161
16868182-1	2007	We have demonstrated that lipopolysaccharide (LPS)-mediated reactive oxygen species (ROS) and signal transduction are involved in the regulation of interleukin-1 (IL-1) beta gene expression within macrophages.	Reactive Oxygen Species	85-88	interleukin 1 alpha	Homo sapiens	148-161
17079228-5	2006	In this study, we found that toxin inhibition of type 2A protein phosphatases greatly enhances interleukin 1 (IL-1)-dependent phosphorylation of Thr-187 in the TAK1 activation loop as well as the catalytic activity of TAK1.	Threonine	145-148	interleukin 1 alpha	Homo sapiens	95-114
17077500-1	2006	S100A13 is a member of the S100 family of EF-hand-containing calcium-binding proteins and plays an important role in the secretion of fibroblast growth factor-1 and interleukin 1alpha, two pro-angiogenic factors released by the endoplasmic reticulum/Golgi-independent non-classical secretory pathway.	Calcium	61-68	interleukin 1 alpha	Homo sapiens	165-183
17026971-5	2006	Carbachol stimulation of SH-SY5Y cells dose-dependently stimulated the activation of the transcription factors NFkappaB and AP-1 as revealed by electrophoretic mobility shift assay (EMSA), while pre-exposure of SH-SY5Y cells for 24 h with 1 ng/ml IL-1beta completely suppressed the carbachol response.	Carbachol	0-9	interleukin 1 alpha	Homo sapiens	247-255
17026971-6	2006	mAChR-mediated enhancements of AChE activity by carbachol were impaired following pre-exposure of SH-SY5Y cells with IL-1beta, already detectable at a concentration of 1 ng/ml and 1 h of exposure time.	Carbachol	48-57	interleukin 1 alpha	Homo sapiens	117-125
18040817-6	2006	IL-1 signaling is required for the production of amygdala PGE(2) in response to surgical stress, and may thus affect the physiological and psychological aspects of surgical stress.	Prostaglandins E	58-61	interleukin 1 alpha	Homo sapiens	0-4
17077523-6	2006	We showed that GJWGM inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-6, and IL-8 induced by LPS in dose dependent manner (p&lt;0.05).	gjwgm	15-20	interleukin 1 alpha	Homo sapiens	84-107
16965524-3	2006	This study aimed to investigate IL-1A gene polymorphism in Cyclosporin A (CsA)-treated renal transplant patients and investigate the association between this polymorphism and gingival crevicular fluid (GCF) levels of several cytokines.	Cyclosporine	74-77	interleukin 1 alpha	Homo sapiens	32-37
16796997-4	2006	Further, omega-3 eicosapentaenoic acid is capable of down-regulating the production and effect of a number of mediators of cachexia, such as IL-1, IL-6, TNF-alpha and proteolysis-inducing factor.	Eicosapentaenoic Acid	9-38	interleukin 1 alpha	Homo sapiens	141-145
16965524-8	2006	IL-1alpha, IL-1beta and IL-8, but not IL-6, were detected in GCF of CsA-treated patients, but none of them was significantly associated with gingival overgrowth.	Cyclosporine	68-71	interleukin 1 alpha	Homo sapiens	0-9
16965524-9	2006	CONCLUSIONS: This study is the first to associate a gene polymorphism as a risk factor for CsA-induced gingival overgrowth in renal transplant patients, demonstrating that IL-1A polymorphism might alter individual susceptibility to CsA.	Cyclosporine	91-94	interleukin 1 alpha	Homo sapiens	172-177
16996234-0	2006	Determination of interleukin-1alpha in human NCTC 2544 keratinocyte cells as a predictor of skin irritation from lysine-based surfactants.	Lysine	113-119	interleukin 1 alpha	Homo sapiens	17-35
16996234-5	2006	Lysine derivatives proved to be less potent in stimulating IL-1 alpha synthesis and induced a lower release of this cytokine into the culture medium when compared to the anionic surfactant sodium dodecyl sulfate.	Lysine	0-6	interleukin 1 alpha	Homo sapiens	59-69
16916584-0	2006	Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.	Alcohols	74-81	interleukin 1 alpha	Homo sapiens	0-19
16795034-0	2006	Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.	Lysophospholipids	0-17	interleukin 1 alpha	Homo sapiens	112-116
18970797-2	2006	IL-1alpha was immobilized through its surface amine groups via amide bonds with the carboxyl groups of the carboxymethyl dextran (CMD) on cuvette surface.	Amines	46-51	interleukin 1 alpha	Homo sapiens	0-9
18970797-2	2006	IL-1alpha was immobilized through its surface amine groups via amide bonds with the carboxyl groups of the carboxymethyl dextran (CMD) on cuvette surface.	Amides	63-68	interleukin 1 alpha	Homo sapiens	0-9
18970797-2	2006	IL-1alpha was immobilized through its surface amine groups via amide bonds with the carboxyl groups of the carboxymethyl dextran (CMD) on cuvette surface.	carboxymethyl dextran	107-128	interleukin 1 alpha	Homo sapiens	0-9
18970797-7	2006	For this assay, the K(D) was 2.6x10(-6)M. The CMD cuvette modified by IL-1alpha was successfully regenerated using 10mM HCl, and the same sensing surface was used repeatedly for the interaction analysis.	Hydrochloric Acid	120-123	interleukin 1 alpha	Homo sapiens	70-79
17018645-4	2006	A&gt;or=24-h exposure to DHA reduced COX-2 expression and activity induced by IL-1, without affecting COX-1 expression.	Docosahexaenoic Acids	25-28	interleukin 1 alpha	Homo sapiens	78-82
18172961-12	2006	CONCLUSION: It can be concluded that pentoxifylline can prevent further degradation of nitrogen in patients suffering from phlegmona of the foot, decreasing the catabolic effect of infection, most probably by inhibiting the effect of TNF-alpha, interleukin-1 and interleukin-6, without any significant effect on leukocytosis during four days of treatment.	Pentoxifylline	37-51	interleukin 1 alpha	Homo sapiens	245-258
16984260-5	2006	IL-1alpha triggered cellular changes consistent with nuclear factor-kappaB pathway activation as well as reduced AR mRNA and protein expression levels for DHT-stimulated DPC.	Dihydrotestosterone	155-158	interleukin 1 alpha	Homo sapiens	0-9
16984260-5	2006	IL-1alpha triggered cellular changes consistent with nuclear factor-kappaB pathway activation as well as reduced AR mRNA and protein expression levels for DHT-stimulated DPC.	dpc	170-173	interleukin 1 alpha	Homo sapiens	0-9
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	SB 203580	245-253	interleukin 1 alpha	Homo sapiens	142-160
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	SB 203580	245-253	interleukin 1 alpha	Homo sapiens	162-171
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	U 0126	311-316	interleukin 1 alpha	Homo sapiens	142-160
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	U 0126	311-316	interleukin 1 alpha	Homo sapiens	162-171
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	interleukin 1 alpha	Homo sapiens	142-160
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	interleukin 1 alpha	Homo sapiens	162-171
16953813-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated t-PA production, respectively (p &lt; 0.05).	SB 203580	49-57	interleukin 1 alpha	Homo sapiens	105-114
16953813-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated t-PA production, respectively (p &lt; 0.05).	U 0126	59-64	interleukin 1 alpha	Homo sapiens	105-114
16953813-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	interleukin 1 alpha	Homo sapiens	105-114
16828270-5	2006	These fatty acids also decrease the production of the classic inflammatory cytokines tumour necrosis factor, interleukin-1, and interleukin-6 and the expression of adhesion molecules involved in inflammatory interactions between leukocytes and endothelial cells.	Fatty Acids	6-17	interleukin 1 alpha	Homo sapiens	109-141
16952320-8	2006	RESULTS: Aspirin significantly decreased growth rate in a dose-dependent manner, alone and as a combined treatment with IL-1 with a maximum reduction in growth rate at 300 mg/ml (P &lt; 0.05).	Aspirin	9-16	interleukin 1 alpha	Homo sapiens	120-124
16869801-4	2006	Aspirin-treated DCs are partially resistant to phenotypic changes following maturational stimuli, such as lipopolysaccharide (LPS) or TNFalpha, IL-1alpha and PGE2.	Aspirin	0-7	interleukin 1 alpha	Homo sapiens	144-153
17042265-1	2006	We found that the tritium-labeled synthetic ACTH-like octapeptide leucocorticotropin corresponding to the 81-88 sequence of the precursor of human interleukin-1alpha ([3H]GKVLKKRR) is bound by the ACTH receptor of rat adrenal cortex with a high affinity and specificity (Kd 2.2 +/- 0.1 nM).	Tritium	18-25	interleukin 1 alpha	Homo sapiens	147-165
16914593-11	2006	TNFalpha and IL1 (0.1 ng/ml) increased hyaluronic acid production by 44 and 95% (P&lt;0.01) respectively.	Hyaluronic Acid	39-54	interleukin 1 alpha	Homo sapiens	13-16
16914593-12	2006	Anti-cytokine agents inhibited these responses by 79-138% (P&lt;0.04).0.013 AU and -1.0; P&lt;0.03) whilst IL1 (0.1 ng/ml) stimulated adipogenesis (+0.05 AU and +5.7; P&lt;0.02) measured by oil-red-O extraction and visual assessment respectively.	oil red O	190-199	interleukin 1 alpha	Homo sapiens	107-110
16914593-14	2006	CONCLUSION: TNFalpha and IL1 stimulate ICAM1 expression and GAG production, but have opposite effects on adipogenesis in OFs in vitro.	Glycosaminoglycans	60-63	interleukin 1 alpha	Homo sapiens	25-28
16879223-8	2006	Preincubation of HUVEC with 10 microm pravastatin significantly reduced IL-1-induced PAI-1 expression in 4G/4G HUVEC compared with untreated cultures (177.5% +/- 24.5% vs. 257.9% +/- 39.0%, P &lt; 0.05).	Pravastatin	38-49	interleukin 1 alpha	Homo sapiens	72-76
16478776-0	2006	Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.	Nitric Oxide	121-133	interleukin 1 alpha	Homo sapiens	68-77
16478776-6	2006	When thyrotropin (TSH)-incubated normal and GD thyrocytes were treated with IL-1alpha/IFN-gamma, TPO and ThOXs protein and mRNA expression dropped, a decrease partially prevented by L-NAME, suggesting that NO acts as a mediator of Th1 effects.	NG-Nitroarginine Methyl Ester	182-188	interleukin 1 alpha	Homo sapiens	76-85
18079991-4	2006	Peripheral and central administration of IL-1 also induces norepinephrine (NE) release in the brain, most markedly in the hypothalamus.	Norepinephrine	59-73	interleukin 1 alpha	Homo sapiens	41-45
18079991-6	2006	IL-1 also increases brain concentrations of tryptophan, and the metabolism of serotonin (5-HT) throughout the brain in a regionally nonselective manner.	Tryptophan	44-54	interleukin 1 alpha	Homo sapiens	0-4
16861626-5	2006	Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1alpha, MIP-1alpha, and IL-10 being comparable to that seen in the uninfected controls.	ivermectin-albendazole	55-77	interleukin 1 alpha	Homo sapiens	150-159
16448811-2	2006	Pyocyanin-induced synergism with interleukin (IL)-1 or tumour necrosis factor (TNF) in triggering IL-8 release has been documented previously.	Pyocyanine	0-9	interleukin 1 alpha	Homo sapiens	33-51
16827719-8	2006	Both mRNA expression and protein production of MMP-1 were up-regulated by interleukin-1alpha, either alone or in combination with nifedipine, whereas those of TIMP-1 were up-regulated by nifedipine alone or in combination with interleukin-1alpha.	Nifedipine	130-140	interleukin 1 alpha	Homo sapiens	74-92
16879223-9	2006	Pravastatin also attenuated the amount of secreted PAI-1 by 4G/4G HUVEC after IL-1 stimulation (5020.6 +/- 165.7 ng mL(-1) vs. 4261.1 +/- 309.8 ng mL(-1), P &lt; 0.05).	Pravastatin	0-11	interleukin 1 alpha	Homo sapiens	78-82
16818127-6	2006	n-3 fatty acids resulted in a 59% reduction in TNF-alpha (from 1.64 to 0.68 pg/ml; p = 0.02) and 39% decrease in IL-1 (from 1.98 to 1.21 pg/ml; p = 0.09) production.	Fatty Acids, Omega-3	0-15	interleukin 1 alpha	Homo sapiens	113-117
17081438-10	2006	RESULTS: The size of the RT-PCR product of hIL-1ra fragments was approximately 500 bp in agarose gel electrophoresis.	Sepharose	89-96	interleukin 1 alpha	Homo sapiens	43-48
16802354-0	2006	Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes.	Calcium	28-35	interleukin 1 alpha	Homo sapiens	11-24
16802354-7	2006	Thapsigargin, U73122, and pertussis toxin inhibited the percentage of cells responding to IL-1.	Thapsigargin	0-12	interleukin 1 alpha	Homo sapiens	90-94
16802354-9	2006	CONCLUSION: Both isolated and in situ chondrocytes respond to IL-1 with transient increases in [Ca2+]i via intracellular Ca2+ release mediated by the phospholipase C and inositol trisphosphate pathways.	inositol 1,2,3-trisphosphate	170-192	interleukin 1 alpha	Homo sapiens	62-66
16803918-6	2006	RESULTS: In comparison with sevoflurane, propofol was associated with a lower concentration of plasma creatinine (P &lt; 0.05) together with lower concentrations of myeloperoxidase, tumour necrosis factor-alpha, interleukin 1-ss, interferon-gamma, superoxide anion and superoxidase dismutase, malondialdehyde and inducible nitric oxide synthase (P &lt; 0.05).	Propofol	41-49	interleukin 1 alpha	Homo sapiens	212-225
17240945-12	2006	Seric levels of IL-1 and TNF-alpha were also higher in RES-NPT group (7,537 and 5,399 pg/ml, respectively) than in RES-NPT-SID group (6,397 and 5,032 pg/ml respectively) (p&lt;0,001).	seric	0-5	interleukin 1 alpha	Homo sapiens	16-20
16609893-7	2006	RESULTS: The presence of IL-1 induced an inhibition of PG synthesis in knee and ankle articular chondrocytes.	pg	55-57	interleukin 1 alpha	Homo sapiens	25-29
16609893-9	2006	CONCLUSION: Ankle chondrocytes are more resistant to IL-1 induced inhibition of PG synthesis than chondrocytes from the knee.	pg	80-82	interleukin 1 alpha	Homo sapiens	53-57
16885604-1	2006	BACKGROUND &amp; OBJECTIVES: Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring anti-inflammatory molecule that blocks action of IL-1.	Adenosine Monophosphate	12-15	interleukin 1 alpha	Homo sapiens	64-68
16755241-6	2006	The mechanism of action is thought to be that aminobisphosphonates transiently stimulate the production of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha.	aminobisphosphonates	46-66	interleukin 1 alpha	Homo sapiens	141-154
16644476-7	2006	Moreover, another PI3K inhibitor 3-methyladenine also strongly enhanced IL-1-induced NF-kappaB DNA binding, while LY303511, an inactive analogue of LY29, did not increase the NF-kappaB DNA binding.	3-methyladenine	33-48	interleukin 1 alpha	Homo sapiens	72-76
16644476-11	2006	Likewise, prostaglandin E2 production by IL-1 was increased by LY29, but not by WM.	Dinoprostone	10-26	interleukin 1 alpha	Homo sapiens	41-45
16596202-4	2006	The aim of this study was to evaluate whether abnormalities in the blood levels of IL-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and human IL-1 accessory protein in HCV+ patients are associated with development of MC and/or NHL.	Methylcholanthrene	233-235	interleukin 1 alpha	Homo sapiens	83-87
16353157-6	2006	We show that phenoxodiol inhibits hallmarks of endothelial cell activation, namely TNF or IL-1 induced E-selectin and VCAM-1 expression and IL-8 secretion.	phenoxodiol	13-24	interleukin 1 alpha	Homo sapiens	90-94
16532021-0	2006	Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin.	Quercetin	90-99	interleukin 1 alpha	Homo sapiens	14-18
16723648-3	2006	Since oral epithelial cells participate importantly in periodontal inflammation, we measured simvastatin effects on interleukin-6 and interleukin-8 production by cultured human epithelial cell line (KB cells) in response to interleukin-1alpha.	Simvastatin	93-104	interleukin 1 alpha	Homo sapiens	224-242
16532021-5	2006	We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated.	Quercetin	48-57	interleukin 1 alpha	Homo sapiens	165-169
16532021-6	2006	The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Go6976 completely inhibited IL-1-induced IL-6 production.	SB 203580	18-26	interleukin 1 alpha	Homo sapiens	95-99
16532021-6	2006	The p38 inhibitor SB203580 and the PKC inhibitors Calphostin C and Go6976 completely inhibited IL-1-induced IL-6 production.	Go 6976	67-73	interleukin 1 alpha	Homo sapiens	95-99
16532021-7	2006	Quercetin 1-100 microM inhibited IL-1-induced IL-6 secretion, p38 and PKC-theta phosphorylation in a dose-dependent manner.	quercetin 1	0-11	interleukin 1 alpha	Homo sapiens	33-37
16532021-8	2006	These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved.	Quercetin	168-177	interleukin 1 alpha	Homo sapiens	28-32
16540955-9	2006	Ischemic preconditioning, mediated by nitric oxide, reduced IL-1 release and protected against lung damage.	Nitric Oxide	38-50	interleukin 1 alpha	Homo sapiens	60-64
16540955-10	2006	Nitric oxide synthesis inhibition in the preconditioned group led to increased IL-1 levels and increased lung damage following ROLT, whereas the addition of IL-1 receptor antagonist protected against the injurious effects of nitric oxide inhibition.	Nitric Oxide	0-12	interleukin 1 alpha	Homo sapiens	79-83
16540955-11	2006	In addition, nitric oxide pretreatment gave similar results in terms of IL-1alpha and lung protection to those found in preconditioning.	Nitric Oxide	13-25	interleukin 1 alpha	Homo sapiens	72-81
16540955-14	2006	Similarly, nitric oxide synthesis inhibition in the preconditioned group, which increased IL-1alpha and lung damage, reduced systemic sTNFR2 and increased free TNF levels.	Nitric Oxide	11-23	interleukin 1 alpha	Homo sapiens	90-99
16596202-4	2006	The aim of this study was to evaluate whether abnormalities in the blood levels of IL-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and human IL-1 accessory protein in HCV+ patients are associated with development of MC and/or NHL.	Methylcholanthrene	233-235	interleukin 1 alpha	Homo sapiens	92-96
16596202-4	2006	The aim of this study was to evaluate whether abnormalities in the blood levels of IL-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and human IL-1 accessory protein in HCV+ patients are associated with development of MC and/or NHL.	Methylcholanthrene	233-235	interleukin 1 alpha	Homo sapiens	92-96
16596202-5	2006	Relative to healthy controls, we observed: i) an increase in the circulating levels of IL-1beta in HCV+ patients simultaneously affected by NHL; ii) increased levels of IL-1 accessory protein in patients singly infected by HCV; iii) increase of IL-1 receptor antagonist in HCV+ patients and in those affected also by NHL with or without MC; iv) a homogeneous increase of sIL-1R type II in all the subgroup of patients.	Methylcholanthrene	337-339	interleukin 1 alpha	Homo sapiens	169-173
16549374-4	2006	[(3)H]thymidine incorporation in HUVEC treated with TNF-alpha or IL-1alpha significantly decreased, in the absence or in the presence of the hormone, while the levels of vitamin D receptor markedly increased in the presence of 1,25(OH)(2)D(3) alone or associated with TNF-alpha or IL-1alpha, in comparison to the control.	Thymidine	6-15	interleukin 1 alpha	Homo sapiens	65-74
16549374-4	2006	[(3)H]thymidine incorporation in HUVEC treated with TNF-alpha or IL-1alpha significantly decreased, in the absence or in the presence of the hormone, while the levels of vitamin D receptor markedly increased in the presence of 1,25(OH)(2)D(3) alone or associated with TNF-alpha or IL-1alpha, in comparison to the control.	Thymidine	6-15	interleukin 1 alpha	Homo sapiens	281-290
16423868-4	2006	PGE(2) and PGF(2alpha) stimulate expression of IL-1alpha, -1beta, and -6, findings consistent with PG involvement in IL signaling within the seminiferous tubule.	Prostaglandins E	0-3	interleukin 1 alpha	Homo sapiens	47-72
16423868-4	2006	PGE(2) and PGF(2alpha) stimulate expression of IL-1alpha, -1beta, and -6, findings consistent with PG involvement in IL signaling within the seminiferous tubule.	Prostaglandins F	11-14	interleukin 1 alpha	Homo sapiens	47-72
16423868-4	2006	PGE(2) and PGF(2alpha) stimulate expression of IL-1alpha, -1beta, and -6, findings consistent with PG involvement in IL signaling within the seminiferous tubule.	Prostaglandins	0-2	interleukin 1 alpha	Homo sapiens	47-72
16517748-0	2006	Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes.	Calcitriol	86-110	interleukin 1 alpha	Homo sapiens	36-45
16581766-3	2006	Interleukin-1 (IL-1) stimulation of SP-A expression is mediated by NF-kappaB (p65/p50) activation and increased binding to the TBE.	tbe	127-130	interleukin 1 alpha	Homo sapiens	0-19
16517748-10	2006	Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes.	Vitamin D	41-50	interleukin 1 alpha	Homo sapiens	141-150
16476030-5	2006	RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls.	Dexamethasone	23-36	interleukin 1 alpha	Homo sapiens	73-83
16512913-12	2006	CONCLUSION: It is hypothesized that the known increase of lesion-associated extracellular ATP contributes via P2X7 activation to release IL-1 beta which in turn induces COX-2 and downstream pathogenic mediators.	Adenosine Triphosphate	90-93	interleukin 1 alpha	Homo sapiens	137-146
17173569-6	2006	RESULTS: Human fibroblasts respond to UVR or to IL-1 by increasing the production of various inflammatory mediators including PGE-2, IL-1, and IL-6 and proteases such as collagenase (MMP-1).	Prostaglandins E	126-129	interleukin 1 alpha	Homo sapiens	48-52
17173569-7	2006	Treatment of fibroblasts with 10 microm of CoQ10 suppressed the UVR- or IL-1-induced increase in PGE-2, IL-6, and MMP-1.	Prostaglandins E	97-100	interleukin 1 alpha	Homo sapiens	72-76
16476030-5	2006	RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls.	Dexamethasone	23-36	interleukin 1 alpha	Homo sapiens	134-144
16492524-7	2006	Fluorescein isothiocyanate (FITC)-labeled anti-ICAM-1 and FITC-labeled anti-VCAM-1 were used to analyze the IL-1alpha-induced expression of ICAM-1 and VCAM-1 by flow cytometry.	Fluorescein-5-isothiocyanate	0-26	interleukin 1 alpha	Homo sapiens	108-117
16492524-7	2006	Fluorescein isothiocyanate (FITC)-labeled anti-ICAM-1 and FITC-labeled anti-VCAM-1 were used to analyze the IL-1alpha-induced expression of ICAM-1 and VCAM-1 by flow cytometry.	Fluorescein-5-isothiocyanate	28-32	interleukin 1 alpha	Homo sapiens	108-117
16645274-4	2006	An association of the disease with ApoE and IL-1beta polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD.	Cholesterol	94-105	interleukin 1 alpha	Homo sapiens	44-52
16358339-3	2006	We have reported previously that IL-1 markedly enhances excitotoxic injury induced in the rat by striatal administration of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), leading to widespread neuronal loss throughout the ipsilateral cortex.	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate	140-192	interleukin 1 alpha	Homo sapiens	33-37
16358339-3	2006	We have reported previously that IL-1 markedly enhances excitotoxic injury induced in the rat by striatal administration of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), leading to widespread neuronal loss throughout the ipsilateral cortex.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	194-198	interleukin 1 alpha	Homo sapiens	33-37
16358339-8	2006	In addition, the anticonvulsant diazepam (intraperitoneal) significantly reduced cell death (P &lt; 0.001) and seizure duration (P &lt; 0.001) induced by AMPA with IL-1, and a significant correlation was found between seizure duration and cell death volume.	Diazepam	32-40	interleukin 1 alpha	Homo sapiens	164-168
16912431-8	2006	The results show that LPS and IL-1alpha increase intracellular IL-1beta and Diacerein inhibited LPS-induced and IL-1alpha induced IL-1beta production by articular chondrocytes.	diacerein	76-85	interleukin 1 alpha	Homo sapiens	30-39
16912431-8	2006	The results show that LPS and IL-1alpha increase intracellular IL-1beta and Diacerein inhibited LPS-induced and IL-1alpha induced IL-1beta production by articular chondrocytes.	diacerein	76-85	interleukin 1 alpha	Homo sapiens	112-121
16354107-3	2006	IL-1, known to inhibit glucose-induced insulin secretion by stimulating inducible nitric oxide synthase expression and increased production of nitric oxide by beta-cells, also induces beta-cell death.	Nitric Oxide	82-94	interleukin 1 alpha	Homo sapiens	0-4
16354107-6	2006	In contrast, IL-1 stimulates the release of the immunological adjuvant high mobility group box 1 protein (HMGB1; a biochemical maker of necrosis) in a nitric oxide-dependent manner, while apoptosis inducers fail to stimulate HMGB1 release.	Nitric Oxide	151-163	interleukin 1 alpha	Homo sapiens	13-17
16433908-9	2006	This synergistic effect of IL-1 alpha on NTHi-induced beta-defensin 2 up-regulation appeared to be mediated by the p38 MAP kinase pathway.	nthi	41-45	interleukin 1 alpha	Homo sapiens	27-37
16300728-3	2006	Moreover, vanadium exposure was also found to cause the synthesis of inflammatory cytokines, such as interleukin-1, tumor necrosis factor-alpha, and prostaglandin E(2).	Vanadium	10-18	interleukin 1 alpha	Homo sapiens	101-143
16297587-4	2006	However, in the baseline dementia-free cohort considered as a whole, independently of other confounders, IL-1beta-511 T/T homozygotes had lower plasma tHcy than both heterozygotes (P=0.036) and wild-types (P=0.004).	thcy	151-155	interleukin 1 alpha	Homo sapiens	105-113
16297587-6	2006	The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD.	thcy	51-55	interleukin 1 alpha	Homo sapiens	64-72
16410064-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha-stimulated t-PA production, respectively (p &lt; 0.05).	SB 203580	49-57	interleukin 1 alpha	Homo sapiens	105-114
16676119-5	2006	Incubation of reconstructed epidermis with taurine inhibited cytotoxic and proinflammatory effects induced by sodium dodecyl sulfate including (i) a decrease in interleukin-1 alpha and prostaglandin E2 release, (ii) stabilization of keratinocyte membrane integrity, and (iii) improvement of keratinocyte viability.	Taurine	43-50	interleukin 1 alpha	Homo sapiens	161-180
16410064-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha-stimulated t-PA production, respectively (p &lt; 0.05).	U 0126	59-64	interleukin 1 alpha	Homo sapiens	105-114
16676119-5	2006	Incubation of reconstructed epidermis with taurine inhibited cytotoxic and proinflammatory effects induced by sodium dodecyl sulfate including (i) a decrease in interleukin-1 alpha and prostaglandin E2 release, (ii) stabilization of keratinocyte membrane integrity, and (iii) improvement of keratinocyte viability.	Sodium Dodecyl Sulfate	110-132	interleukin 1 alpha	Homo sapiens	161-180
16410064-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	interleukin 1 alpha	Homo sapiens	105-114
16150868-0	2006	Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.	Serine	99-105	interleukin 1 alpha	Homo sapiens	0-18
16261637-7	2006	Preconditioning inhibited IL-1 through nitric oxide (NO), thereby protecting against the injurious effects of IL-1.	Nitric Oxide	39-51	interleukin 1 alpha	Homo sapiens	26-30
16261637-7	2006	Preconditioning inhibited IL-1 through nitric oxide (NO), thereby protecting against the injurious effects of IL-1.	Nitric Oxide	39-51	interleukin 1 alpha	Homo sapiens	110-114
16150868-6	2006	Chemical inhibitors for these kinases inhibited IL-1alpha-induced serine phosphorylation of IRS-1.	Serine	66-72	interleukin 1 alpha	Homo sapiens	48-57
16150868-10	2006	Taken together, short-term IL-1alpha treatment transiently causes insulin resistance at IRS-1 level with its serine phosphorylation.	Serine	109-115	interleukin 1 alpha	Homo sapiens	27-36
16543969-0	2006	The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway.	17-dihydroequilenin	24-47	interleukin 1 alpha	Homo sapiens	60-78
16543969-5	2006	17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels.	17-dihydroequilenin	0-23	interleukin 1 alpha	Homo sapiens	84-93
16543969-5	2006	17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels.	Estradiol	28-44	interleukin 1 alpha	Homo sapiens	84-93
16543969-8	2006	The effect of 17beta-dihydroequilenin on IL-1alpha-induced production of IL-6, IL-8 and MCP-1 was reversed by the estrogen receptor antagonist ICI 182,780.	17-dihydroequilenin	14-37	interleukin 1 alpha	Homo sapiens	41-50
16543969-9	2006	17beta-dihydroequilenin also inhibited IL-1alpha-induced translocation of p50 and p65 to the nucleus of the cells.	17-dihydroequilenin	0-23	interleukin 1 alpha	Homo sapiens	39-48
16095823-4	2005	LPS+IL-(1beta) induced oxidative injury as assessed by ROS production (29%), GSH depletion (11%) and loss of mitochondrial activity (22%).	ros	55-58	interleukin 1 alpha	Homo sapiens	4-13
17027524-8	2006	Several in vitro studies have shown that IL-1 stimulates the production of mediators such as prostaglandin E(2), nitric oxide, cytokines, chemokines, and adhesion molecules that are involved in articular inflammation.	Dinoprostone	93-111	interleukin 1 alpha	Homo sapiens	41-45
17027524-8	2006	Several in vitro studies have shown that IL-1 stimulates the production of mediators such as prostaglandin E(2), nitric oxide, cytokines, chemokines, and adhesion molecules that are involved in articular inflammation.	Nitric Oxide	113-125	interleukin 1 alpha	Homo sapiens	41-45
16298681-8	2005	These results suggest that immunomodulatory cytokines might exert an inhibitory effect on NO up-regulation by colonic epithelium via the inhibition of MMC-derived soluble mediators, such as IL-1.	Mitomycin	151-154	interleukin 1 alpha	Homo sapiens	190-194
16095823-4	2005	LPS+IL-(1beta) induced oxidative injury as assessed by ROS production (29%), GSH depletion (11%) and loss of mitochondrial activity (22%).	Glutathione	77-80	interleukin 1 alpha	Homo sapiens	4-13
16209712-10	2005	IL-1alpha stimulation and Coll IV adhesion enhanced the activation of Ras, as evidenced by the increased Ras-GTP levels in pancreatic cancer cells.	ras-gtp	105-112	interleukin 1 alpha	Homo sapiens	0-9
16297161-8	2005	Endogenous PGE(2) further enhanced IL-1alpha-induced OPG production in HGF.	Prostaglandins E	11-14	interleukin 1 alpha	Homo sapiens	35-44
16249450-0	2005	Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?	Glucose	86-93	interleukin 1 alpha	Homo sapiens	37-50
16209712-13	2005	PD98059, a MEK inhibitor, also inhibited IL-1alpha-induced enhancement of adhesion and invasion in pancreatic cancer cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 alpha	Homo sapiens	41-50
16183790-5	2005	Recombinant human interleukin-1alpha (rhIL-1alpha) increased the secretion of MMP-1, MMP-2, MMP-3, and PGE2 in the fibroblasts.	Dinoprostone	103-107	interleukin 1 alpha	Homo sapiens	18-36
16413516-4	2005	Adenosine pretreatment resulted in a reduction in IL-8 expression and secretion in response to TNF-alpha, IL-1, LPS, and PMA.	Adenosine	0-9	interleukin 1 alpha	Homo sapiens	106-110
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Acetylcysteine	62-65	interleukin 1 alpha	Homo sapiens	77-86
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Reactive Oxygen Species	95-98	interleukin 1 alpha	Homo sapiens	77-86
16192891-0	2005	Interleukin-1alpha enhances IL-8 secretion through p38 mitogen-activated protein kinase and reactive oxygen species signaling in human pancreatic cancer cells.	Reactive Oxygen Species	92-115	interleukin 1 alpha	Homo sapiens	0-18
16192891-10	2005	IL-1alpha also induced production of ROS.	Reactive Oxygen Species	37-40	interleukin 1 alpha	Homo sapiens	0-9
16192891-15	2005	CONCLUSIONS: These results suggest that MAPK/AP-1 and ROS/NF-kappaB signaling pathways are involved in IL-1alpha-induced IL-8 secretion and that these paracrine signaling pathways enhance endothelial cell proliferation.	Reactive Oxygen Species	54-57	interleukin 1 alpha	Homo sapiens	103-112
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Acetylcysteine	43-60	interleukin 1 alpha	Homo sapiens	77-86
16015023-0	2005	FK506 (tacrolimus) inhibition of intracellular production and enhancement of interleukin 1alpha through glucocorticoid application to chemically treated human keratinocytes.	Tacrolimus	0-5	interleukin 1 alpha	Homo sapiens	77-95
16202919-0	2005	Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix.	cyclodextrin polysulphates	0-26	interleukin 1 alpha	Homo sapiens	35-39
16202919-12	2005	CDPS-treated cells expressed significantly lower amounts of intracellular IL-1alpha and -beta levels.	cdps	0-4	interleukin 1 alpha	Homo sapiens	74-93
16002475-0	2005	Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells.	Benzo(a)pyrene	126-140	interleukin 1 alpha	Homo sapiens	44-62
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	interleukin 1 alpha	Homo sapiens	13-22
16015023-0	2005	FK506 (tacrolimus) inhibition of intracellular production and enhancement of interleukin 1alpha through glucocorticoid application to chemically treated human keratinocytes.	Tacrolimus	7-17	interleukin 1 alpha	Homo sapiens	77-95
16015023-2	2005	A study was made to confirm whether immunosuppressants such as the macrocyclic lactone FK506 (tacrolimus) possibly serve to modulate glucocorticoid- stimulated IL-1alpha production from chemically treated KCs.	Lactones	79-86	interleukin 1 alpha	Homo sapiens	160-169
16015023-2	2005	A study was made to confirm whether immunosuppressants such as the macrocyclic lactone FK506 (tacrolimus) possibly serve to modulate glucocorticoid- stimulated IL-1alpha production from chemically treated KCs.	Tacrolimus	87-92	interleukin 1 alpha	Homo sapiens	160-169
16015023-2	2005	A study was made to confirm whether immunosuppressants such as the macrocyclic lactone FK506 (tacrolimus) possibly serve to modulate glucocorticoid- stimulated IL-1alpha production from chemically treated KCs.	Tacrolimus	94-104	interleukin 1 alpha	Homo sapiens	160-169
16015023-3	2005	METHODS: Using cultured human KCs, the effects of FK506 on the production of IL-1alpha treated with chemicals (trinitrobenzene sulfonic acid sodium salt, TNBS) plus hydrocortisone were analyzed by ELISA and mRNA expression of IL-1alpha using RT-PCR.	Tacrolimus	50-55	interleukin 1 alpha	Homo sapiens	77-86
16015023-3	2005	METHODS: Using cultured human KCs, the effects of FK506 on the production of IL-1alpha treated with chemicals (trinitrobenzene sulfonic acid sodium salt, TNBS) plus hydrocortisone were analyzed by ELISA and mRNA expression of IL-1alpha using RT-PCR.	Trinitrobenzenesulfonic Acid	111-152	interleukin 1 alpha	Homo sapiens	77-86
16015023-4	2005	RESULTS: Intracellular IL-1alpha in TNBS-treated human KCs was increased with a low concentration of 10(-10)M of hydrocortisone.	Hydrocortisone	113-127	interleukin 1 alpha	Homo sapiens	23-32
16015023-7	2005	CONCLUSIONS: FK506may control the increase in IL-1alpha with glucocorticoid in KCs, suggesting FK506 to suppress harmful effects of glucocorticoids such as steroid rosacea.	fk506may	13-21	interleukin 1 alpha	Homo sapiens	46-55
16015023-7	2005	CONCLUSIONS: FK506may control the increase in IL-1alpha with glucocorticoid in KCs, suggesting FK506 to suppress harmful effects of glucocorticoids such as steroid rosacea.	Tacrolimus	13-18	interleukin 1 alpha	Homo sapiens	46-55
16130848-7	2005	Immune modification using local steroids and disease-modifying antirheumatic drugs, such as hydroxychloroquine, are known to inhibit inflammatory cells and cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor, which are responsible for pain and tissue damage.	Steroids	32-40	interleukin 1 alpha	Homo sapiens	175-188
16162440-7	2005	The much larger improvement of FMD due to ciprofibrate therapy was accompanied by significant reductions of cholesterol (by 14.4%), fibrinogen, IL-1alpha, and sICAM levels and by significant increase of high-density lipoprotein (HDL) cholesterol concentration, but the change in FMD correlated only with the reduction of the cholesterol level.	ciprofibrate	42-54	interleukin 1 alpha	Homo sapiens	144-153
16081838-4	2005	VX-765, an orally active IL-converting enzyme/caspase-1 inhibitor, blocked IL-1beta secretion with equal potency in LPS-stimulated cells from FCAS and control subjects.	belnacasan	0-6	interleukin 1 alpha	Homo sapiens	75-83
16022722-8	2005	Both TGF-beta1 and IL-1alpha significantly stimulated accumulation of C 4-S PG by bACs in 3D porous collagen sponges.	4-s	72-75	interleukin 1 alpha	Homo sapiens	19-28
16022722-10	2005	Addition of TGF-beta1 and IL-1alpha for 11 days significantly stimulated accumulation of C 4-S PG by hDFs cultured in DMEM with 1% Nutridoma.	imciromab pentetate	89-94	interleukin 1 alpha	Homo sapiens	26-35
16022722-10	2005	Addition of TGF-beta1 and IL-1alpha for 11 days significantly stimulated accumulation of C 4-S PG by hDFs cultured in DMEM with 1% Nutridoma.	dmem	118-122	interleukin 1 alpha	Homo sapiens	26-35
16130848-7	2005	Immune modification using local steroids and disease-modifying antirheumatic drugs, such as hydroxychloroquine, are known to inhibit inflammatory cells and cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor, which are responsible for pain and tissue damage.	Hydroxychloroquine	92-110	interleukin 1 alpha	Homo sapiens	175-188
15930731-0	2005	Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1 mediated pathway.	evodiamine	0-10	interleukin 1 alpha	Homo sapiens	71-84
15819602-9	2005	Hesperetin and quercetin-3-glucoside reduced changes in H&amp;E, 8-OHdG, TUNEL and IL-1alpha.	hesperetin	0-10	interleukin 1 alpha	Homo sapiens	83-92
15819602-9	2005	Hesperetin and quercetin-3-glucoside reduced changes in H&amp;E, 8-OHdG, TUNEL and IL-1alpha.	isoquercitrin	15-36	interleukin 1 alpha	Homo sapiens	83-92
15819602-10	2005	Quercetin-3-glucoside reduced the amount of IL-1alpha in LSE media.	isoquercitrin	0-21	interleukin 1 alpha	Homo sapiens	44-53
15930731-6	2005	In conclusion, IL-1-induced death cascade in melanoma A375-S2 cell might be one of the targets for natural product evodiamine, and increased Fas-L expression via IL-1 mediated pathway stands at the initiation phase, leading to consequent events that culminate in the death of the cells.	evodiamine	115-125	interleukin 1 alpha	Homo sapiens	15-19
15948687-0	2005	Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with interleukin-1alpha.	Dinoprostone	27-48	interleukin 1 alpha	Homo sapiens	192-210
15843470-3	2005	IL-6 production induced by IL-1, TNF-alpha, and IL-17 was specifically inhibited by the c-jun NH(2)-terminal kinase (JNK) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited.	pyrazolanthrone	132-140	interleukin 1 alpha	Homo sapiens	27-31
15843470-6	2005	Furthermore, IL-1-induced transcriptional activation of the IL-6 promotor was repressed by SP600125 or by co-transfection of a dominant-negative expression plasmid of c-jun even in the absence of a functional AP-1 binding site.	pyrazolanthrone	91-99	interleukin 1 alpha	Homo sapiens	13-17
15948687-6	2005	RESULTS: IL-1alpha enhanced both MMP-3 and PGE2 production.	Dinoprostone	43-47	interleukin 1 alpha	Homo sapiens	9-18
16050491-4	2005	Fibroblasts derived from nifedipine responders showed significantly higher cell proliferation rate in the presence of nifedipine and IL-1alpha, than nifedipine or IL-lalpha alone on both the second and the fourth day of incubation (P &lt; 0.05).	Nifedipine	25-35	interleukin 1 alpha	Homo sapiens	133-142
29539150-6	2005	RESULTS: IL-1alpha enhanced both MMP-3 and PGE2 production.	Dinoprostone	43-47	interleukin 1 alpha	Homo sapiens	9-18
29539150-0	2005	Cyclooxygenase-2-Dependent Prostaglandin (PG) E2 Downregulates Matrix Metalloproteinase-3 Production via EP2 /EP4 Subtypes of PGE2 Receptors in Human Periodontal Ligament Cells Stimulated With Interleukin-1alpha.	Dinoprostone	27-48	interleukin 1 alpha	Homo sapiens	193-211
15948687-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	33-42
15948687-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	17-23	interleukin 1 alpha	Homo sapiens	33-42
15948687-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Dinoprostone	166-170	interleukin 1 alpha	Homo sapiens	148-157
15948687-8	2005	Exogenous PGE2 reduced IL-1alpha-induced MMP-3 production in a dose-dependent manner.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	23-32
15948687-9	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced MMP-3 production, although butaprost was less potent than ONO-AE-1-329.	butaprost	0-9	interleukin 1 alpha	Homo sapiens	102-111
15948687-9	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced MMP-3 production, although butaprost was less potent than ONO-AE-1-329.	ONO-AE1-329	40-51	interleukin 1 alpha	Homo sapiens	102-111
15948687-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	dibutyryl	0-9	interleukin 1 alpha	Homo sapiens	102-111
15948687-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Cyclic AMP	10-14	interleukin 1 alpha	Homo sapiens	102-111
29539150-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	33-42
15948687-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Cyclic AMP	18-22	interleukin 1 alpha	Homo sapiens	102-111
15948687-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Colforsin	35-44	interleukin 1 alpha	Homo sapiens	102-111
29539150-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	17-23	interleukin 1 alpha	Homo sapiens	33-42
15948687-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2/EP4 receptors in human PDL cells.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	72-81
29539150-7	2005	Indomethacin and NS-398 enhanced IL-1alpha-induced MMP-3 production in PDL cells, to the same extent, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Dinoprostone	166-170	interleukin 1 alpha	Homo sapiens	148-157
15948687-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2/EP4 receptors in human PDL cells.	Cyclic AMP	111-115	interleukin 1 alpha	Homo sapiens	72-81
29539150-8	2005	Exogenous PGE2 reduced IL-1alpha-induced MMP-3 production in a dose-dependent manner.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	23-32
29539150-9	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced MMP-3 production, although butaprost was less potent than ONO-AE-1-329.	butaprost	0-9	interleukin 1 alpha	Homo sapiens	102-111
29539150-9	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced MMP-3 production, although butaprost was less potent than ONO-AE-1-329.	ONO-AE1-329	40-51	interleukin 1 alpha	Homo sapiens	102-111
29539150-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	dibutyryl	0-9	interleukin 1 alpha	Homo sapiens	102-111
29539150-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Cyclic AMP	10-14	interleukin 1 alpha	Homo sapiens	102-111
29539150-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Cyclic AMP	18-22	interleukin 1 alpha	Homo sapiens	102-111
29539150-10	2005	Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells.	Colforsin	35-44	interleukin 1 alpha	Homo sapiens	102-111
29539150-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	72-81
29539150-11	2005	CONCLUSIONS: These data suggest that COX-2-dependent PGE2 downregulates IL-1alpha-elicited MMP-3 production by cAMP-dependent pathways via EP2 /EP4 receptors in human PDL cells.	Cyclic AMP	111-115	interleukin 1 alpha	Homo sapiens	72-81
15735656-3	2005	We have contrasted the effects of a synthetic glucocorticoid, dexamethasone, on thrombin- and IL-1alpha-stimulated GM-CSF production in human ASM cells.	Dexamethasone	62-75	interleukin 1 alpha	Homo sapiens	94-103
15741158-8	2005	In addition to a marked reduction in neutrophil influx, 1 reversed increases in inflammatory mediators interleukin-1alpha, interleukin-1beta, tissue necrosis factor-alpha, and monocyte chemotactic protein-1 in the glycogen model and reversed increases in airway nitric oxide levels in the lipopolysaccharide model.	Glycogen	214-222	interleukin 1 alpha	Homo sapiens	103-121
15942912-5	2005	Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes (LTs) and by reducing the auto-induction of interleukin1alpha (IL-1alpha)-induced pro-IL-1beta gene expression.	gamma-Linolenic Acid	0-19	interleukin 1 alpha	Homo sapiens	162-179
15942912-5	2005	Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes (LTs) and by reducing the auto-induction of interleukin1alpha (IL-1alpha)-induced pro-IL-1beta gene expression.	gamma-Linolenic Acid	0-19	interleukin 1 alpha	Homo sapiens	181-190
15735656-4	2005	Although IL-1alpha stimulated three-fold higher levels of GM-CSF mRNA and protein compared to thrombin, dexamethasone concentration-dependently reduced IL-1alpha-stimulated GM-CSF more potently and to a greater extent than the response to thrombin.	Dexamethasone	104-117	interleukin 1 alpha	Homo sapiens	152-161
15735656-7	2005	Dexamethasone treatment reduced luciferase expression stimulated by both IL-1alpha and thrombin.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	73-82
15735656-9	2005	This IL-1alpha-induced GM-CSF mRNA stability was prevented by either dexamethasone or the p38(MAPK) inhibitor, SB203580, neither of which influenced GM-CSF mRNA stability in thrombin-treated cells.	Dexamethasone	69-82	interleukin 1 alpha	Homo sapiens	5-14
15735656-9	2005	This IL-1alpha-induced GM-CSF mRNA stability was prevented by either dexamethasone or the p38(MAPK) inhibitor, SB203580, neither of which influenced GM-CSF mRNA stability in thrombin-treated cells.	SB 203580	111-119	interleukin 1 alpha	Homo sapiens	5-14
15735656-10	2005	Dexamethasone inhibited p38(MAPK) phosphorylation in IL-1alpha-stimulated ASM, whereas thrombin does not stimulate p38(MAPK) phosphorylation.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	53-62
15800392-7	2005	Inhibitory activities of plant extracts towards cytokine activated NF-kappaB and AP-1 depend to some extent on the order of addition of IL-1 and plant extract to the cell culture, but the mechanism of action of extract components is not clear: although plant polyphenols may participate they are unlikely to be the only mediators, and MAP kinases were found generally not involved in down-regulation of transcription factors activity by plant extracts.	Polyphenols	259-270	interleukin 1 alpha	Homo sapiens	136-140
15864048-4	2005	We observed elevation of all three proinflammatory cytokines tested (interleukin-6, interleukin-1, and tumor necrosis factor-alpha) in response to polyethylene particulate challenge when compared with the controls in both patient groups.	Polyethylene	147-159	interleukin 1 alpha	Homo sapiens	84-130
15842260-0	2005	Interleukin-1 levels in gingival crevicular fluid adjacent to restorations of calcium aluminate cement and resin composite.	calcium aluminate	78-95	interleukin 1 alpha	Homo sapiens	0-13
15779068-7	2005	TAS reduced mRNA levels of COX-2, TNF-alpha, IL-8, IL-6, and IL-1alpha, while resveratrol impaired early expression of IL-8 and TNF-alpha.	tas	0-3	interleukin 1 alpha	Homo sapiens	61-70
16556968-6	2005	The interpretation of cytokine levels in the blood is complicated by the fact, for example, that the overexpression of IL-1 in Alzheimer brain may act to increase adrenal cortisol production through the hypothalamic-pituitary-adrenal axis, which acts to limit macrophage activation and peripheral cytokine production.	Hydrocortisone	171-179	interleukin 1 alpha	Homo sapiens	119-123
15728660-7	2005	Simvastatin reduced TPA- and PDGF/IL-1-induced MMP-9 secretion and mRNA levels, effects reversed by geranylgeranyl pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase (ROCK).	Simvastatin	0-11	interleukin 1 alpha	Homo sapiens	34-38
15728660-7	2005	Simvastatin reduced TPA- and PDGF/IL-1-induced MMP-9 secretion and mRNA levels, effects reversed by geranylgeranyl pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase (ROCK).	geranylgeranyl pyrophosphate	100-128	interleukin 1 alpha	Homo sapiens	34-38
15728661-4	2005	In untreated cells, IL-1 induced a prolonged increase of free intracellular calcium, which was required for ERK activation.	Calcium	76-83	interleukin 1 alpha	Homo sapiens	20-24
15749462-0	2005	The effect of hyaluronic acid on interleukin-1-induced deregulation of collagen metabolism in cultured human skin fibroblasts.	Hyaluronic Acid	14-29	interleukin 1 alpha	Homo sapiens	33-46
15749462-7	2005	The data suggest that hyaluronic acid protects collagen against IL-1-induced inhibition of biosynthesis of this protein in cultured human skin fibroblasts at the level of IGF-IR signaling.	Hyaluronic Acid	22-37	interleukin 1 alpha	Homo sapiens	64-68
21966756-11	2005	CONCLUSIONS: Choriodecidual plasma from blood stimulated with GBS is enriched with biochemical signals that enhance the MMP-9, IL-1alpha and TNF-beta production by amniochorion.	gbs	62-65	interleukin 1 alpha	Homo sapiens	127-136
15787580-1	2005	[reaction: see text] The kinetics of the rearrangement of the Z-phenylhydrazone of 3-benzoyl-5-phenyl-1,2,4-oxadiazole (1a) into the relevant 4-benzoylamino-2,5-diphenyl-1,2,3-triazole (2a) induced by amines have been studied in two room-temperature ionic liquids (IL-1, [BMIM][BF4] and IL-2, [BMIM][PF6]).	z-phenylhydrazone	62-79	interleukin 1 alpha	Homo sapiens	265-269
15787580-1	2005	[reaction: see text] The kinetics of the rearrangement of the Z-phenylhydrazone of 3-benzoyl-5-phenyl-1,2,4-oxadiazole (1a) into the relevant 4-benzoylamino-2,5-diphenyl-1,2,3-triazole (2a) induced by amines have been studied in two room-temperature ionic liquids (IL-1, [BMIM][BF4] and IL-2, [BMIM][PF6]).	3-benzoyl-5-phenyl-1,2,4-oxadiazole	83-118	interleukin 1 alpha	Homo sapiens	265-269
15787580-1	2005	[reaction: see text] The kinetics of the rearrangement of the Z-phenylhydrazone of 3-benzoyl-5-phenyl-1,2,4-oxadiazole (1a) into the relevant 4-benzoylamino-2,5-diphenyl-1,2,3-triazole (2a) induced by amines have been studied in two room-temperature ionic liquids (IL-1, [BMIM][BF4] and IL-2, [BMIM][PF6]).	4-benzoylamino-2,5-diphenyl-1,2,3-triazole	142-184	interleukin 1 alpha	Homo sapiens	265-269
15777258-5	2005	Thiopental and ketamine inhibit the endotoxin-induced TNF-alpha, IL-1 and IL-8 responses and increase IL-10 release in vitro.	Thiopental	0-10	interleukin 1 alpha	Homo sapiens	65-69
15777258-5	2005	Thiopental and ketamine inhibit the endotoxin-induced TNF-alpha, IL-1 and IL-8 responses and increase IL-10 release in vitro.	Ketamine	15-23	interleukin 1 alpha	Homo sapiens	65-69
15777258-6	2005	Ketamine prevent the pro-inflammatory cytokine (TNF-alpha, IL-1, and IL-6) responses to endotoxemia in vivo.	Ketamine	0-8	interleukin 1 alpha	Homo sapiens	59-63
15780952-6	2005	The addition of cell-permeable PKI, an inhibitor of the cAMP/PKA signaling pathway, to the cocultures 8 h after the IL-1alpha stimulation inhibited IL-1alpha-induced TRAP+ cell formation.	Cyclic AMP	56-60	interleukin 1 alpha	Homo sapiens	148-157
15629465-5	2005	Triptolide was effective at low doses and blocked the induction of MMP-13 by IL-1 in human and bovine cartilage explants.	triptolide	0-10	interleukin 1 alpha	Homo sapiens	77-81
15629465-6	2005	TWHF extract and PG490 also suppressed IL-1-, IL-17-, and TNF-alpha-induced expression of ADAMTS-4 in bovine chondrocytes.	triptolide	17-22	interleukin 1 alpha	Homo sapiens	39-43
15780952-7	2005	IL-1alpha-induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2, or PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	72-77	interleukin 1 alpha	Homo sapiens	0-9
15780952-7	2005	IL-1alpha-induced TRAP+ cell formation was completely blocked by either NS398, a selective inhibitor of cyclooxygenase (COX)-2, or PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	interleukin 1 alpha	Homo sapiens	0-9
15780952-8	2005	Pretreatment with NS398 and PD98059 also inhibited both the up-regulation of RANKL and the down-regulation of OPG expression by IL-1alpha in PDL cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	28-35	interleukin 1 alpha	Homo sapiens	128-137
15780952-9	2005	IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	44-51	interleukin 1 alpha	Homo sapiens	130-139
15780952-9	2005	IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells.	Dinoprostone	101-107	interleukin 1 alpha	Homo sapiens	0-9
15780952-9	2005	IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells.	Dinoprostone	101-107	interleukin 1 alpha	Homo sapiens	130-139
15780952-11	2005	These results suggest that IL-1alpha stimulates osteoclast formation by increasing the expression level of RANKL versus OPG via ERK-dependent PGE2 production in PDL cells.	Dinoprostone	142-146	interleukin 1 alpha	Homo sapiens	27-36
15679580-6	2005	Maximal increase in IL-1alpha secretion occurred within 2 h after exposure to both nickel sulfate and SDS and prior to increased chemokine secretion.	nickel sulfate	83-97	interleukin 1 alpha	Homo sapiens	20-29
15679580-6	2005	Maximal increase in IL-1alpha secretion occurred within 2 h after exposure to both nickel sulfate and SDS and prior to increased chemokine secretion.	Sodium Dodecyl Sulfate	102-105	interleukin 1 alpha	Homo sapiens	20-29
15389590-4	2005	Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h).	Colforsin	27-36	interleukin 1 alpha	Homo sapiens	108-127
15389590-4	2005	Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h).	Colforsin	27-36	interleukin 1 alpha	Homo sapiens	129-138
15389590-4	2005	Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h).	Colforsin	228-237	interleukin 1 alpha	Homo sapiens	108-127
15612948-0	2005	Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression via EP1 receptors by prostaglandin E2 in human periodontal ligament cells.	Dinoprostone	106-122	interleukin 1 alpha	Homo sapiens	19-37
15389590-4	2005	Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h).	Colforsin	228-237	interleukin 1 alpha	Homo sapiens	129-138
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	137-146
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	250-259
15612948-2	2005	IL-1alpha enhanced both MMP-13 and PGE2 production.	Dinoprostone	35-39	interleukin 1 alpha	Homo sapiens	0-9
15899045-3	2005	For this purpose, nitric oxide production was evaluated using the Griess colorimetric reaction in culture medium of cells stimulated over 48 hours with leptin (800 nmol/l) and IL-1 (0.025 ng/ml), alone or combined.	Nitric Oxide	18-30	interleukin 1 alpha	Homo sapiens	176-180
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	59-65	interleukin 1 alpha	Homo sapiens	137-146
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	59-65	interleukin 1 alpha	Homo sapiens	250-259
15612948-3	2005	Indomethacin, a nonselective cyclooxygenase inhibitor, and NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, significantly enhanced IL-1alpha-induced MMP-13 production in periodontal ligament cells, although both the agents completely inhibited IL-1alpha-induced PGE2 production.	Dinoprostone	268-272	interleukin 1 alpha	Homo sapiens	137-146
15612948-4	2005	Exogenous PGE2 reduced IL-1alpha-induced MMP-13 mRNA and protein production in a dose-dependent manner.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	23-32
15612948-5	2005	17-phenyl-omega-trinor PGE2, a selective EP1 receptor agonist, mimicked the inhibitory effect of PGE2 on IL-1alpha-induced MMP-13 mRNA and protein production.	17-phenyltrinorprostaglandin E2	0-27	interleukin 1 alpha	Homo sapiens	105-114
15612948-5	2005	17-phenyl-omega-trinor PGE2, a selective EP1 receptor agonist, mimicked the inhibitory effect of PGE2 on IL-1alpha-induced MMP-13 mRNA and protein production.	Dinoprostone	23-27	interleukin 1 alpha	Homo sapiens	105-114
15612948-6	2005	On the basis of these data, we suggest that COX-2-dependent PGE2 down-regulates IL-1alpha-elicited MMP-13 production via EP1 receptors in human periodontal ligament cells.	Dinoprostone	60-64	interleukin 1 alpha	Homo sapiens	80-89
15899045-8	2005	However, co-stimulation with leptin and IL-1 resulted in a net increase in nitric oxide concentration over IL-1 challenge that was eliminated by pretreatment with the NOS II specific inhibitor aminoguanidine.	Nitric Oxide	75-87	interleukin 1 alpha	Homo sapiens	40-44
15899045-8	2005	However, co-stimulation with leptin and IL-1 resulted in a net increase in nitric oxide concentration over IL-1 challenge that was eliminated by pretreatment with the NOS II specific inhibitor aminoguanidine.	pimagedine	193-207	interleukin 1 alpha	Homo sapiens	40-44
16277680-4	2005	Recently, we reported that tumour necrosis factor (TNF)-alpha, IL-1alpha, IL-1beta and IL-17 enhance Cyp7b mRNA expression and induce a concomitant increase in the formation of 7alpha-OH-DHEA by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis patients.	7-hydroxydehydroepiandrosterone	177-191	interleukin 1 alpha	Homo sapiens	63-72
15641080-6	2005	RESULTS: Antagonists of IL-1 and TNFalpha inhibited the increase in CII cleavage by collagenase as well as the increase in GAG release observed in OA cartilage compared with normal cartilage.	Glycosaminoglycans	123-126	interleukin 1 alpha	Homo sapiens	24-28
15899045-6	2005	Our results indicate that stimulation of chondrocytes with IL-1 results in dose-dependent nitric oxide production.	Nitric Oxide	90-102	interleukin 1 alpha	Homo sapiens	59-63
15899045-8	2005	However, co-stimulation with leptin and IL-1 resulted in a net increase in nitric oxide concentration over IL-1 challenge that was eliminated by pretreatment with the NOS II specific inhibitor aminoguanidine.	pimagedine	193-207	interleukin 1 alpha	Homo sapiens	107-111
15899045-9	2005	Pretreatment with tyrphostin AG490 and Tkip (a SOCS-1 mimetic peptide that inhibits JAK2) blocked nitric oxide production induced by leptin/IL-1.	Tyrphostins	18-28	interleukin 1 alpha	Homo sapiens	140-144
16121032-2	2005	Generation of nitric oxide (NO) in response to IL-1 is implicated in these actions.	Nitric Oxide	14-26	interleukin 1 alpha	Homo sapiens	47-51
15899045-9	2005	Pretreatment with tyrphostin AG490 and Tkip (a SOCS-1 mimetic peptide that inhibits JAK2) blocked nitric oxide production induced by leptin/IL-1.	Nitric Oxide	98-110	interleukin 1 alpha	Homo sapiens	140-144
16121032-10	2005	In keeping with this observation, the protein synthesis inhibitor cycloheximide abolished the stimulatory effect of IL-1 on ATPase-mediated extrusion.	Cycloheximide	66-79	interleukin 1 alpha	Homo sapiens	116-120
16121032-11	2005	The upregulation of ATPase activity by IL-1 was inhibited by the NOS inhibitor L-NAME and by the NO scavenger PTIO.	NG-Nitroarginine Methyl Ester	79-85	interleukin 1 alpha	Homo sapiens	39-43
16121032-11	2005	The upregulation of ATPase activity by IL-1 was inhibited by the NOS inhibitor L-NAME and by the NO scavenger PTIO.	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	110-114	interleukin 1 alpha	Homo sapiens	39-43
16040399-7	2005	The T-cell proliferative response to DC was enhanced by inclusion of PGE2 in the MCM-mimic (TNF-a, IL-1 a, IL-6, PGE2) cocktail.	Dinoprostone	69-73	interleukin 1 alpha	Homo sapiens	99-105
15903175-8	2005	Implant loss in the examined group (n = 22) was 32 of 106 (30.1%); 10 (45%) of the 22 patients were smokers, and 6 (27%) of the 22 patients were IL-1 genotype positive.	implant	0-7	interleukin 1 alpha	Homo sapiens	145-149
15523637-10	2004	Notably, IL1 mRNA levels in the neuronal cells were increased by PGJ2 treatment.	9-deoxy-delta-9-prostaglandin D2	65-69	interleukin 1 alpha	Homo sapiens	9-12
16435585-5	2005	The amount of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 in PBMC culture supernatant was significantly increased in the lipopolysaccaride (LPS)- or desferrioxamine (DFX)-treated cells compared with unstimulated cells.	lipopolysaccaride	162-179	interleukin 1 alpha	Homo sapiens	49-72
16435585-5	2005	The amount of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 in PBMC culture supernatant was significantly increased in the lipopolysaccaride (LPS)- or desferrioxamine (DFX)-treated cells compared with unstimulated cells.	Deferoxamine	190-205	interleukin 1 alpha	Homo sapiens	49-72
16435585-7	2005	Also, DCWGG inhibited TNF-alpha, IL-1alpha, IL-beta, IL-6, and IL-8 production-induced DFX in dose-dependent manner.	Deferoxamine	87-90	interleukin 1 alpha	Homo sapiens	33-42
15489227-0	2004	Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.	Serine	79-85	interleukin 1 alpha	Homo sapiens	17-30
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	8-Bromo Cyclic Adenosine Monophosphate	192-204	interleukin 1 alpha	Homo sapiens	0-9
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-246	interleukin 1 alpha	Homo sapiens	0-9
15571984-3	2004	Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition.	Hydrogen Peroxide	64-81	interleukin 1 alpha	Homo sapiens	27-40
15574499-0	2004	IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation.	Serine	40-47	interleukin 1 alpha	Homo sapiens	68-72
15571984-3	2004	Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition.	Hydrogen Peroxide	83-87	interleukin 1 alpha	Homo sapiens	27-40
15854322-7	2004	Indomethacin, an inhibitor of prostaglandin synthesis, significantly reduced IL-11 production by HGFs stimulated with IL-1alpha and TNF-alpha individually or in combination.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	118-127
15246961-8	2004	In addition, CCL28 mRNA expression and protein secretion by those cells were significantly increased by the short-chain fatty acid n-butyrate, and IL-1- or flagellin-stimulated upregulation of CCL28 by colon epithelial cells was synergistically increased by pretreatment of cells with n-butyrate.	Butyrates	285-295	interleukin 1 alpha	Homo sapiens	147-151
15488879-8	2004	The use of atorvastatin when compared to diet alone, resulted in significant (P &lt;0.0001) reductions for: LDL-cholesterol (39.9% versus 4.4%), TNF (21.4% versus 2.9%), IL-6 (22.1% versus 2.0%), IL-1 (16.4% versus 2.7%) and sICAM-1 (9.6% versus 0.1%), respectively.	Atorvastatin	11-23	interleukin 1 alpha	Homo sapiens	196-200
15488879-10	2004	CONCLUSION: In hypercholesterolemic patients, atorvastatin, compared to diet alone resulted in significant reductions in levels of proinflammatory cytokines (TNF, IL-1 and IL-6) as well as in sICAM-1 and CRP.	Atorvastatin	46-58	interleukin 1 alpha	Homo sapiens	163-167
15587751-4	2004	Calcitriol treatment for 6 months significantly increased BMD and reduced serum IL-1 and TNF-alpha concentrations compared with no significant changes in patients treated with calcium alone.	Calcitriol	0-10	interleukin 1 alpha	Homo sapiens	80-84
15587751-8	2004	Significant reductions in serum IL-1 and TNF-alpha concentrations suggest that, in addition to increasing the absorption of calcium, calcitriol may directly affect bone metabolism via cytokines.	Calcitriol	133-143	interleukin 1 alpha	Homo sapiens	32-36
15854322-7	2004	Indomethacin, an inhibitor of prostaglandin synthesis, significantly reduced IL-11 production by HGFs stimulated with IL-1alpha and TNF-alpha individually or in combination.	Prostaglandins	30-43	interleukin 1 alpha	Homo sapiens	118-127
15854322-8	2004	IL-1alpha alone or combined with TNF-alpha enhanced the ratio of IL-11/GAPDH mRNA expression in HGFs, and the augmentation was abolished by indomethacin after co-incubation for 24 hs.	Indomethacin	140-152	interleukin 1 alpha	Homo sapiens	0-9
15854322-9	2004	CONCLUSIONS: Production of IL-11 in HGFs stimulated with IL-1alpha and TNF-alpha was transcriptionally upregulated by the endogenous prostaglandin synthesis.	Prostaglandins	133-146	interleukin 1 alpha	Homo sapiens	57-66
15289446-4	2004	Relaxin blunted the endotoxin-induced production of inflammatory cytokines (IL-1, IL-6, TNF-alpha) by human macrophages--an effect that was suppressed by the GR antagonist RU-486.	Mifepristone	172-178	interleukin 1 alpha	Homo sapiens	76-80
15476228-15	2004	Methotrexate reduced synovial IL-1alpha, IL-1beta, IL-8, IL-10, IL-15, IFNgamma, and TNFalpha mRNA expression, but the effect was significant only for IL-8.	Methotrexate	0-12	interleukin 1 alpha	Homo sapiens	30-39
15480072-2	2004	Under conditions of stress because of biomechanical factors, however, chondrocytes are capable of producing mediators that are associated with inflammation, including cytokines such as interleukin-1 and tumor necrosis factor-alpha, which in turn stimulate the production of prostaglandins and nitric oxide.	Prostaglandins	274-288	interleukin 1 alpha	Homo sapiens	185-230
15480072-2	2004	Under conditions of stress because of biomechanical factors, however, chondrocytes are capable of producing mediators that are associated with inflammation, including cytokines such as interleukin-1 and tumor necrosis factor-alpha, which in turn stimulate the production of prostaglandins and nitric oxide.	Nitric Oxide	293-305	interleukin 1 alpha	Homo sapiens	185-230
15381721-6	2004	Antisense oligonucleotides to p65, but not the p50 subunit of NF-kappaB, suppress the IL-1alpha-induced expression of cathepsin K.	Oligonucleotides	10-26	interleukin 1 alpha	Homo sapiens	86-95
15474071-10	2004	CONCLUSION(S): The results suggest that IL-1alpha stimulates the production of IL-8 and M-CSF by a mechanism that involves the sphingomyelin-ceramide system.	Sphingomyelins	127-140	interleukin 1 alpha	Homo sapiens	40-49
15474071-10	2004	CONCLUSION(S): The results suggest that IL-1alpha stimulates the production of IL-8 and M-CSF by a mechanism that involves the sphingomyelin-ceramide system.	Ceramides	141-149	interleukin 1 alpha	Homo sapiens	40-49
15474071-1	2004	OBJECTIVE: To measure the level of interleukin 6 (IL-6), IL-8, and macrophage colony-stimulating factor (M-CSF) induced by IL-1alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues.	Ceramides	193-201	interleukin 1 alpha	Homo sapiens	123-132
15525570-0	2004	Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis.	Steroids	0-7	interleukin 1 alpha	Homo sapiens	78-96
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Cholesterol	62-73	interleukin 1 alpha	Homo sapiens	197-206
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Alcohols	75-82	interleukin 1 alpha	Homo sapiens	197-206
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Estradiol	97-113	interleukin 1 alpha	Homo sapiens	197-206
15070811-9	2004	We conclude that IL-1 cytokines can regulate cellular Glc phosphorylating capacity via an IL-1 receptor-, Ras-, and classic MAPK pathway-mediated increase in HKII abundance.	Glucose	54-57	interleukin 1 alpha	Homo sapiens	17-21
15517885-4	2004	Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	297-301
15128598-7	2004	BZK induced rapid cell death, IL-1 release, and IL-6 secretion.	Benzalkonium Compounds	0-3	interleukin 1 alpha	Homo sapiens	30-34
15356059-4	2004	Addition of cortisol to OSE cell culture medium dose-dependently suppressed the COX-2 mRNA response to IL1alpha (P &lt; 0.01) but reciprocally enhanced the 11betaHSD1 mRNA response (P &lt; 0.05), with both effects strongest at 1 microm cortisol.	Hydrocortisone	12-20	interleukin 1 alpha	Homo sapiens	103-111
15356059-6	2004	Glucocorticoid receptor antagonist (RU486, 10 microm) fully reversed the inhibitory effect of 1 microm cortisol on IL1alpha-stimulated COX-2 mRNA expression.	Mifepristone	36-41	interleukin 1 alpha	Homo sapiens	115-123
15356059-6	2004	Glucocorticoid receptor antagonist (RU486, 10 microm) fully reversed the inhibitory effect of 1 microm cortisol on IL1alpha-stimulated COX-2 mRNA expression.	Hydrocortisone	103-111	interleukin 1 alpha	Homo sapiens	115-123
16120427-24	2004	Inhibition of complex I with rotenone increases the expression and synthesis of Bcl-2 and Cox-2, both effects are similar effects to produced by IL-1 in human chondrocytes.	Rotenone	29-37	interleukin 1 alpha	Homo sapiens	145-149
15591651-2	2004	Pentoxifylline (PTX) has the property of inhibiting TNF-alpha, IL-1, and IL-6 production.	Pentoxifylline	0-14	interleukin 1 alpha	Homo sapiens	63-67
15591651-2	2004	Pentoxifylline (PTX) has the property of inhibiting TNF-alpha, IL-1, and IL-6 production.	Pentoxifylline	16-19	interleukin 1 alpha	Homo sapiens	63-67
15246970-10	2004	NS-398 significantly suppressed VEGF and PGE(2) release from IL-1-stimulated gastric fibroblasts; concurrent addition of PGE(2) restored NS-398-inhibited VEGF release.	Prostaglandins E	41-44	interleukin 1 alpha	Homo sapiens	61-65
15246970-9	2004	IL-1 also stimulated PGE(2) production in gastric fibroblasts via COX-2 induction.	Prostaglandins E	21-24	interleukin 1 alpha	Homo sapiens	0-4
15246970-10	2004	NS-398 significantly suppressed VEGF and PGE(2) release from IL-1-stimulated gastric fibroblasts; concurrent addition of PGE(2) restored NS-398-inhibited VEGF release.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 alpha	Homo sapiens	61-65
15070811-9	2004	We conclude that IL-1 cytokines can regulate cellular Glc phosphorylating capacity via an IL-1 receptor-, Ras-, and classic MAPK pathway-mediated increase in HKII abundance.	Glucose	54-57	interleukin 1 alpha	Homo sapiens	90-94
15265271-5	2004	Treatment of cultured brain endothelial cells with inflammatory proteins (LPS, IL-1beta, IL-6, IFN-gamma, TNF-alpha) resulted in a significant increase (p < 0.01) in intracellular levels of reactive oxygen species by 1 h. Inflammatory proteins also caused release of tissue plasminogen activator and increased apoptosis by 24 h in these cells.	Reactive Oxygen Species	190-213	interleukin 1 alpha	Homo sapiens	79-87
15223066-2	2004	A beta(25-35) upregulated the cytokine (TNF-alpha/IL-1 beta)-induced expression of iNOS and the production of nitric oxide (NO) in astrocytes, which were inhibited by vitamin E.	Nitric Oxide	110-122	interleukin 1 alpha	Homo sapiens	50-59
15223066-2	2004	A beta(25-35) upregulated the cytokine (TNF-alpha/IL-1 beta)-induced expression of iNOS and the production of nitric oxide (NO) in astrocytes, which were inhibited by vitamin E.	Vitamin E	167-176	interleukin 1 alpha	Homo sapiens	50-59
15325569-5	2004	The proliferative response of IL-1alpha-stimulated TCFs was examined using the SF formazan solution reaction.	Formazans	82-90	interleukin 1 alpha	Homo sapiens	30-39
15265671-0	2004	15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression.	15-deoxy-delta	0-14	interleukin 1 alpha	Homo sapiens	47-51
15265671-0	2004	15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression.	9-deoxy-delta-9-prostaglandin D2	21-27	interleukin 1 alpha	Homo sapiens	47-51
15265671-2	2004	15d-PGJ2 inhibited a broad range of astrocyte inflammatory gene expression induced by IL-1, including cytokines (TNFalpha and IL-6), chemokines (RANTES/CCL5 and IP-10/CXCL10) and inducible nitric oxide synthase.	15-deoxyprostaglandin J2	0-8	interleukin 1 alpha	Homo sapiens	86-90
15265671-3	2004	15d-PGJ2 inhibited transactivation of NF-kappaB-dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN-induced Stat signaling pathways.	15-deoxyprostaglandin J2	0-8	interleukin 1 alpha	Homo sapiens	124-128
15118486-8	2004	Compared with untreated patients and healthy control subjects, IL-1beta levels and expression decreased in Alzheimer disease patients treated with Donepezil (P < 0.001).	Donepezil	147-156	interleukin 1 alpha	Homo sapiens	63-71
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	Dinoprostone	27-31	interleukin 1 alpha	Homo sapiens	9-18
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	mofezolac	114-123	interleukin 1 alpha	Homo sapiens	9-18
15167967-4	2004	RESULTS: IL-1alpha-induced PGE2 production in synovial cells isolated from RA in primary culture was inhibited by mofezolac, a selective inhibitor of COX-1, as well as NS-398, a specific inhibitor of COX-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	168-174	interleukin 1 alpha	Homo sapiens	9-18
15161640-9	2004	Conversely, adding exogenous IL-1alpha completely suppressed endogenous alpha-SMA induction.	alpha-sma	72-81	interleukin 1 alpha	Homo sapiens	29-38
15167223-7	2004	Many mechanisms are involved, including suppression of neoplastic transformation, cell growth inhibition, and enhanced apoptosis and anti-angiogenicity, through the inhibition of eicosanoid production from n-6 fatty acids; and suppression of cyclooxygenase 2 (COX-2), interleukin 1 (IL-1) and IL-6 gene expression by n-3 fatty acids.	Eicosanoids	179-189	interleukin 1 alpha	Homo sapiens	268-288
15135888-4	2004	Treatment with IL-1alpha or IL-6 caused a dose-dependent increase in survival as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.	thiazolyl blue	97-158	interleukin 1 alpha	Homo sapiens	15-24
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	SB 203580	217-225	interleukin 1 alpha	Homo sapiens	128-146
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	SB 203580	217-225	interleukin 1 alpha	Homo sapiens	148-157
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	U 0126	243-248	interleukin 1 alpha	Homo sapiens	128-146
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	U 0126	243-248	interleukin 1 alpha	Homo sapiens	148-157
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	interleukin 1 alpha	Homo sapiens	128-146
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	interleukin 1 alpha	Homo sapiens	148-157
15102045-8	2004	In addition, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated MMP-9 production, respectively (p &lt; 0.05).	SB 203580	13-21	interleukin 1 alpha	Homo sapiens	69-78
15226683-0	2004	[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].	diacerein	25-34	interleukin 1 alpha	Homo sapiens	59-72
15102045-8	2004	In addition, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated MMP-9 production, respectively (p &lt; 0.05).	U 0126	23-28	interleukin 1 alpha	Homo sapiens	69-78
15102045-8	2004	In addition, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated MMP-9 production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 1 alpha	Homo sapiens	69-78
15207276-4	2004	Short-term RT-PCR analysis demonstrated that minocycline partially prevented the lipopolysaccharide-induced increases of mRNA levels for interleukin-1alpha and tumor necrosis factor-alpha.	Minocycline	45-56	interleukin 1 alpha	Homo sapiens	137-187
15115509-3	2004	Topical tacrolimus may inhibit local activation of T lymphocytes through altered expression of cytokines such as interleukin-1, -4 and -5, tumour necrosis factor-alpha and interferon-gamma.	Tacrolimus	8-18	interleukin 1 alpha	Homo sapiens	113-167
15132730-3	2004	Vitamin E, a known antioxidant, inhibits lipid peroxidation; this can lead to protection of islet beta cells from the combined effects of interleukin 1, tumor necrosis factor and gamma interferon.	Vitamin E	0-9	interleukin 1 alpha	Homo sapiens	138-174
15209355-0	2004	N-palmitoylation of the radioprotective domain of interleukin-1 affords inhibition of LPS-induced nitric oxide generation.	Nitrogen	0-1	interleukin 1 alpha	Homo sapiens	50-63
15209355-0	2004	N-palmitoylation of the radioprotective domain of interleukin-1 affords inhibition of LPS-induced nitric oxide generation.	Nitric Oxide	98-110	interleukin 1 alpha	Homo sapiens	50-63
15255281-0	2004	Cyclic mechanical stretching and interleukin-1alpha synergistically up-regulate prostacyclin secretion in cultured human uterine myometrial cells.	Epoprostenol	80-92	interleukin 1 alpha	Homo sapiens	33-51
15051633-7	2004	(1) Although mRNA levels of IL-1alpha and IL-1beta were markedly reduced in PBMCs from CAD patients after 6 months of simvastatin (20 mg/d, n=15) and atorvastatin (80 mg/d, n=15) therapy, the reduction in IL-1 receptor antagonist (IL-1Ra) was more modest.	Simvastatin	118-129	interleukin 1 alpha	Homo sapiens	28-37
15051633-7	2004	(1) Although mRNA levels of IL-1alpha and IL-1beta were markedly reduced in PBMCs from CAD patients after 6 months of simvastatin (20 mg/d, n=15) and atorvastatin (80 mg/d, n=15) therapy, the reduction in IL-1 receptor antagonist (IL-1Ra) was more modest.	Atorvastatin	150-162	interleukin 1 alpha	Homo sapiens	28-37
14633512-1	2004	Induction of surfactant protein-A (SP-A) gene expression in fetal lung type II cells by cAMP and IL-1 is mediated by increased binding of thyroid transcription factor-1 (TTF-1) and NF-B proteins p50 and p65 to the TTF-1-binding element (TBE) at -183 bp.	tbe	237-240	interleukin 1 alpha	Homo sapiens	97-101
14633512-6	2004	In lung cells transfected with a fusion gene containing three TBEs fused to the basal SP-A promoter, Dex prevented the stimulatory effect of IL-1 on TTF-1 induction of SP-A promoter activity, suggesting that the GR inhibits SP-A promoter activity through the TBE.	Dexamethasone	101-104	interleukin 1 alpha	Homo sapiens	141-145
15255281-4	2004	Since elevation of cervical/vaginal interleukin-1alpha (IL-1alpha) concentrations is also a characteristic feature of delivery, and IL-1alpha is a known stimulator of PG synthesis, we investigated a possible synergistic effect of cyclic mechanical stretching and IL-1alpha on PGI2 production in cultured human myometrial cells.	Prostaglandins	167-169	interleukin 1 alpha	Homo sapiens	132-141
15255281-4	2004	Since elevation of cervical/vaginal interleukin-1alpha (IL-1alpha) concentrations is also a characteristic feature of delivery, and IL-1alpha is a known stimulator of PG synthesis, we investigated a possible synergistic effect of cyclic mechanical stretching and IL-1alpha on PGI2 production in cultured human myometrial cells.	Prostaglandins	167-169	interleukin 1 alpha	Homo sapiens	132-141
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Epoprostenol	93-97	interleukin 1 alpha	Homo sapiens	15-24
15068815-7	2004	Butyrate at 10 mM/L inhibited interleukin-1 (IL-1)-stimulated VCAM-1 and ICAM-1 expression.	Butyrates	0-8	interleukin 1 alpha	Homo sapiens	18-49
14989266-6	2004	Interleukin-1, one of the key players in inflammatory response, stimulates the production of ROS itself, but its signaling cascade can also be influenced by ROS and by thiol modifying agents.	Reactive Oxygen Species	93-96	interleukin 1 alpha	Homo sapiens	0-13
14989266-6	2004	Interleukin-1, one of the key players in inflammatory response, stimulates the production of ROS itself, but its signaling cascade can also be influenced by ROS and by thiol modifying agents.	Reactive Oxygen Species	157-160	interleukin 1 alpha	Homo sapiens	0-13
14989266-6	2004	Interleukin-1, one of the key players in inflammatory response, stimulates the production of ROS itself, but its signaling cascade can also be influenced by ROS and by thiol modifying agents.	Sulfhydryl Compounds	168-173	interleukin 1 alpha	Homo sapiens	0-13
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Dinoprostone	99-115	interleukin 1 alpha	Homo sapiens	15-24
14977303-3	2004	Methyl mercaptan (CH3SH), a volatile sulfur compound produced by anaerobic Gram-negative bacteria, has been shown to contribute to the production of IL-1 by human mononuclear cells.	methylmercaptan	0-16	interleukin 1 alpha	Homo sapiens	149-153
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Dinoprostone	117-121	interleukin 1 alpha	Homo sapiens	15-24
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Dinoprost	124-145	interleukin 1 alpha	Homo sapiens	15-24
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Dinoprost	147-156	interleukin 1 alpha	Homo sapiens	15-24
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Thromboxane A2	162-176	interleukin 1 alpha	Homo sapiens	15-24
15255281-5	2004	Treatment with IL-1alpha (10 ng/ml) significantly augmented (4- to 60-fold) the secretion of PGI2, prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha) and thromboxane A2 (TXA2) from cultured human myometrial cells obtained from non-pregnant and pregnant women as well as in cultured human umbilical artery and cultured human coronary artery smooth muscle cells (p &lt; 0.05 for all comparisons).	Thromboxane A2	178-182	interleukin 1 alpha	Homo sapiens	15-24
15255281-6	2004	However, labor-like cyclic mechanical stretching up-regulated IL-1alpha-augmented PGI2 secretion from myometrial cells obtained from non-pregnant and pregnant women 2.1- to 2.8-fold (p &lt; 0.05 for all comparisons), but not PGE2, PGF2alpha nor TXA2.	Epoprostenol	82-86	interleukin 1 alpha	Homo sapiens	62-71
15255281-6	2004	However, labor-like cyclic mechanical stretching up-regulated IL-1alpha-augmented PGI2 secretion from myometrial cells obtained from non-pregnant and pregnant women 2.1- to 2.8-fold (p &lt; 0.05 for all comparisons), but not PGE2, PGF2alpha nor TXA2.	Dinoprostone	225-229	interleukin 1 alpha	Homo sapiens	62-71
15255281-6	2004	However, labor-like cyclic mechanical stretching up-regulated IL-1alpha-augmented PGI2 secretion from myometrial cells obtained from non-pregnant and pregnant women 2.1- to 2.8-fold (p &lt; 0.05 for all comparisons), but not PGE2, PGF2alpha nor TXA2.	Dinoprost	231-240	interleukin 1 alpha	Homo sapiens	62-71
15255281-8	2004	These results suggest that cyclic mechanical stretching by labor, in concert with IL-1alpha stimulation, contributes to the increase in myometrial PGI2 secretion during delivery.	Epoprostenol	147-151	interleukin 1 alpha	Homo sapiens	82-91
14765973-8	2004	More precisely, IL-1 may be involved in several ovulation-associated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production.	Prostaglandins	158-171	interleukin 1 alpha	Homo sapiens	16-20
14765973-8	2004	More precisely, IL-1 may be involved in several ovulation-associated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production.	Nitric Oxide	176-188	interleukin 1 alpha	Homo sapiens	16-20
14977303-3	2004	Methyl mercaptan (CH3SH), a volatile sulfur compound produced by anaerobic Gram-negative bacteria, has been shown to contribute to the production of IL-1 by human mononuclear cells.	methylmercaptan	18-23	interleukin 1 alpha	Homo sapiens	149-153
14977303-3	2004	Methyl mercaptan (CH3SH), a volatile sulfur compound produced by anaerobic Gram-negative bacteria, has been shown to contribute to the production of IL-1 by human mononuclear cells.	Sulfur	37-43	interleukin 1 alpha	Homo sapiens	149-153
14687222-4	2004	We found that pre-treatment of hGF with 5"-AMP induced marked inhibition of granulocyte-macrophage colony-stimulating factor (GM-CSF) production from hGF upon stimulation with interleukin-1alpha (IL-1alpha) by enzyme-linked immunosorbent assay (ELISA).	Adenosine Monophosphate	40-46	interleukin 1 alpha	Homo sapiens	176-194
14741428-3	2004	Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS.	BzATP	46-51	interleukin 1 alpha	Homo sapiens	112-121
14741428-3	2004	Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS.	BzATP	46-51	interleukin 1 alpha	Homo sapiens	249-258
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	BzATP	0-5	interleukin 1 alpha	Homo sapiens	19-28
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	adenosine 5"-triphosphate 2",3"-acyclic dialcohol	148-197	interleukin 1 alpha	Homo sapiens	19-28
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	Adenosine Triphosphate	2-5	interleukin 1 alpha	Homo sapiens	19-28
14687222-4	2004	We found that pre-treatment of hGF with 5"-AMP induced marked inhibition of granulocyte-macrophage colony-stimulating factor (GM-CSF) production from hGF upon stimulation with interleukin-1alpha (IL-1alpha) by enzyme-linked immunosorbent assay (ELISA).	Adenosine Monophosphate	40-46	interleukin 1 alpha	Homo sapiens	196-205
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Sodium Salicylate	119-136	interleukin 1 alpha	Homo sapiens	70-88
15068117-9	2004	IL-1-induced production of PGE2 was not affected in four of six cultures isolated from different individuals.	Dinoprostone	27-31	interleukin 1 alpha	Homo sapiens	0-4
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Mesalamine	222-243	interleukin 1 alpha	Homo sapiens	70-88
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Mesalamine	245-250	interleukin 1 alpha	Homo sapiens	70-88
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Indomethacin	255-267	interleukin 1 alpha	Homo sapiens	70-88
14687581-4	2004	Treatment with IFN-gamma and IL-1alpha for 15 min induced a rapid increase of AA release from NHBE cells, which was blocked by the cPLA(2) inhibitor MAFP (p&lt;0.05) but not by the sPLA(2) inhibitor LY311727 or iPLA(2) inhibitor HELSS.	LY 311727	199-207	interleukin 1 alpha	Homo sapiens	29-38
14687581-4	2004	Treatment with IFN-gamma and IL-1alpha for 15 min induced a rapid increase of AA release from NHBE cells, which was blocked by the cPLA(2) inhibitor MAFP (p&lt;0.05) but not by the sPLA(2) inhibitor LY311727 or iPLA(2) inhibitor HELSS.	ipla	211-215	interleukin 1 alpha	Homo sapiens	29-38
15244502-9	2004	However, a peculiar aspect concerning the action of non-aminobisphosphonates seems to be an anti-inflammatory activity caused by the inhibition of the release of inflammatory mediators from activated macrophages, such as interleukin (IL)-6, tumor necrosis factor-alpha and IL-1.	aminobisphosphonates	56-76	interleukin 1 alpha	Homo sapiens	273-277
15001844-0	2004	Synthesis and biological activities in vitro and in vivo of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N -acetylneuraminyl-galactose.	n -acetylneuraminyl-galactose	132-161	interleukin 1 alpha	Homo sapiens	79-97
15630284-7	2004	Incubation of human aortic endothelial cells (HAECs) with IL-1alpha resulted in increased permeability of quercetin-3-glucuronide.	quercetin 3-O-glucuronide	106-129	interleukin 1 alpha	Homo sapiens	58-67
15290420-2	2004	Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critical role in the cellular responses to extracellular stimuli such as lipopolysaccharide (LPS) and proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 (IL-1).	Isoflurane	148-158	interleukin 1 alpha	Homo sapiens	410-430
15373964-10	2004	Since fever induced by IL-1, TNF-alpha, IL-6 or TLR ligands requires cyclooxygenase-2, production of prostaglandin E2 (PGE2) and activation of hypothalamic PGE2 receptors provides a unifying mechanism for fever by endogenous and exogenous pyrogens.	Dinoprostone	101-117	interleukin 1 alpha	Homo sapiens	23-27
15373964-10	2004	Since fever induced by IL-1, TNF-alpha, IL-6 or TLR ligands requires cyclooxygenase-2, production of prostaglandin E2 (PGE2) and activation of hypothalamic PGE2 receptors provides a unifying mechanism for fever by endogenous and exogenous pyrogens.	Dinoprostone	119-123	interleukin 1 alpha	Homo sapiens	23-27
15630177-3	2004	Surprisingly, zerumbone markedly induced the expression of interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in each cell line in concentration- and time-dependent manners.	zerumbone	14-23	interleukin 1 alpha	Homo sapiens	59-82
15001844-2	2004	Glycosylated IL-1alpha (Neu5Ac-Gal-IL-1alpha) was purified by anion-exchange chromatography and average number of carbohydrate molecules introduced per molecule of IL-1alpha was 2.5.	Carbohydrates	114-126	interleukin 1 alpha	Homo sapiens	35-44
15001844-5	2004	Neu5Ac-Gal-IL-1alpha exhibited reduction in activities in vivo, including induction of serum amyloid A and NOx, and down-regulation of serum glucose.	Glucose	141-148	interleukin 1 alpha	Homo sapiens	11-20
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	N-Acetylneuraminic Acid	188-212	interleukin 1 alpha	Homo sapiens	91-100
15001844-6	2004	However, Neu5Ac-Gal-IL-1alpha exhibited comparable activity to IL-1alpha in improvement of the recovery of peripheral white blood cells from myelosuppression in 5-fluorouracil-treated mice.	Fluorouracil	161-175	interleukin 1 alpha	Homo sapiens	20-29
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	N-Acetylneuraminic Acid	188-212	interleukin 1 alpha	Homo sapiens	150-159
15001844-7	2004	In addition, tissue level of Neu5Ac-Gal-IL-1alpha was relatively high compared to IL-1alpha.	N-Acetylneuraminic Acid	29-35	interleukin 1 alpha	Homo sapiens	40-49
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	neu5ac-gal	235-245	interleukin 1 alpha	Homo sapiens	150-159
15001844-2	2004	Glycosylated IL-1alpha (Neu5Ac-Gal-IL-1alpha) was purified by anion-exchange chromatography and average number of carbohydrate molecules introduced per molecule of IL-1alpha was 2.5.	Carbohydrates	114-126	interleukin 1 alpha	Homo sapiens	13-22
15001844-2	2004	Glycosylated IL-1alpha (Neu5Ac-Gal-IL-1alpha) was purified by anion-exchange chromatography and average number of carbohydrate molecules introduced per molecule of IL-1alpha was 2.5.	Carbohydrates	114-126	interleukin 1 alpha	Homo sapiens	35-44
15477776-3	2004	Therapy with carvedilol in this group was associated with decreases of Il-2 (-23.8%), TNFalpha (-16.7%), IL-1alpha (-12.5%) (p&lt;0.05-0.01).	Carvedilol	13-23	interleukin 1 alpha	Homo sapiens	105-114
14964492-1	2004	OBJECTIVE: This study evaluated the effect of a carbon dioxide (CO2) laser treatment on the clinical parameters and crevicular Interleukin-1 (IL-1beta) levels when used in combination with gingival flap surgery.	Carbon Dioxide	48-62	interleukin 1 alpha	Homo sapiens	127-140
14964492-1	2004	OBJECTIVE: This study evaluated the effect of a carbon dioxide (CO2) laser treatment on the clinical parameters and crevicular Interleukin-1 (IL-1beta) levels when used in combination with gingival flap surgery.	Carbon Dioxide	64-67	interleukin 1 alpha	Homo sapiens	127-140
15487757-5	2004	Copper ions also activate several proangiogenic factors, e.g., vascular endothelial growth factor, basic fibroblast growth factor, tumour necrosis factor alpha and interleukin 1.	Copper	0-6	interleukin 1 alpha	Homo sapiens	164-177
14705223-0	2004	Interleukin 1alpha single-nucleotide polymorphism associated with systemic sclerosis.	single-nucleotide	19-36	interleukin 1 alpha	Homo sapiens	0-18
15477776-7	2004	Therapy with carvedilol was associated with improvement of clinical symptoms and exercise tolerance (+35%, p&lt;0.05)), increase of ejection fraction (+15%, p&lt;0.05), decrease of left ventricular end systolic volume (-17.5%, p&lt;0.05), and lowering of blood levels of TNFalpha (-31%), IL-2 (-17.4%), IL-1alpha (-15.6%).	Carvedilol	13-23	interleukin 1 alpha	Homo sapiens	303-312
15773377-3	2004	The authors suggest using determination of serum antibodies to myeloprotein G and IL-1, IL-6 to specify severity of chronic manganese intoxication.	Manganese	124-133	interleukin 1 alpha	Homo sapiens	82-86
15022609-5	2004	Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving.	Iron	111-115	interleukin 1 alpha	Homo sapiens	29-33
17028801-2	2004	We have previously reported that interleukin-1 (IL-1) inhibited proteoglycan (PG) synthesis and induced the production of ROS in cartilage explants and isolated chondrocyte cultures.	Reactive Oxygen Species	122-125	interleukin 1 alpha	Homo sapiens	33-46
17028801-2	2004	We have previously reported that interleukin-1 (IL-1) inhibited proteoglycan (PG) synthesis and induced the production of ROS in cartilage explants and isolated chondrocyte cultures.	Reactive Oxygen Species	122-125	interleukin 1 alpha	Homo sapiens	48-52
17028801-3	2004	In this study, we report the protective effect of ebselen against IL-1-mediated inhibition of PG synthesis and ROS induction in cultured cartilage explants and chondrocytes.	ebselen	50-57	interleukin 1 alpha	Homo sapiens	66-70
17028801-3	2004	In this study, we report the protective effect of ebselen against IL-1-mediated inhibition of PG synthesis and ROS induction in cultured cartilage explants and chondrocytes.	Reactive Oxygen Species	111-114	interleukin 1 alpha	Homo sapiens	66-70
15201939-3	2004	IL-1 is considered a key mediator in RA joint damage because of its greater capacity (greater than TNF) of increasing matrix degradation by inducing the production of MMPs and PGE2 in synovial cells, as well by its role as mediator of bone and cartilage destruction.	Dinoprostone	176-180	interleukin 1 alpha	Homo sapiens	0-4
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	Chondroitin Sulfates	65-67	interleukin 1 alpha	Homo sapiens	18-27
15201935-1	2004	IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases (MMP), eicosanoids, nitric oxide oxydase (iNOS), receptor activator of NF-kB ligand (RANKL), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption.	Eicosanoids	75-86	interleukin 1 alpha	Homo sapiens	0-4
13679381-2	2003	However, how such stimuli, prototypically represented by transforming growth factor-beta1 (TGF-beta1) and IL-1alpha, modify GAG synthesis during aging of normal human articular cartilage is not known.	Glycosaminoglycans	124-127	interleukin 1 alpha	Homo sapiens	106-115
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	Glycosaminoglycans	57-60	interleukin 1 alpha	Homo sapiens	18-27
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	1-hexene	89-92	interleukin 1 alpha	Homo sapiens	18-27
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	imciromab pentetate	93-96	interleukin 1 alpha	Homo sapiens	18-27
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	1-hexene	110-113	interleukin 1 alpha	Homo sapiens	18-27
14740552-0	2003	[Study on effects of interleukin-1 and their inhibitors for proliferation and hyaluronic acid synthesis of cultured human orbital fibroblasts].	Hyaluronic Acid	78-93	interleukin 1 alpha	Homo sapiens	21-34
13679373-6	2003	The final structure of the IL-1 receptor accessory protein TIR domain suggests the conserved regions box 1 and 2, including Pro-446, as well as box 3 within the C-terminal alpha-helix as possible protein-protein interaction sites due to their exposure and their electrostatic potential.	Proline	124-127	interleukin 1 alpha	Homo sapiens	27-31
13679373-8	2003	Inhibition of IL-1 responsiveness seen after substitution of Pro-446 by charged amino acids is due to the loss of an interaction site for other TIR domains.	Proline	61-64	interleukin 1 alpha	Homo sapiens	14-18
14769228-7	2003	The IL-1, TNF-alpha and IFN-gamma were found in supernatant of OFs treated by patients" serum.	ofs	63-66	interleukin 1 alpha	Homo sapiens	4-8
14633625-8	2003	Serum triglycerides, but not blood glucose were lower in animals with MCF-7IL-1 alpha cell-derived tumors compared to animals with control cell-derived tumors.	Triglycerides	6-19	interleukin 1 alpha	Homo sapiens	75-85
14740552-1	2003	PURPOSE: To observe the proliferation and synthesis of hyaluronic acid (HA) of cultured human orbital fibroblasts (OFs) affected by interleukin-1 (IL-1), and their inhibitors interleukin-1 receptor antagonist(IL-1Ra).	Hyaluronic Acid	55-70	interleukin 1 alpha	Homo sapiens	132-145
14740552-1	2003	PURPOSE: To observe the proliferation and synthesis of hyaluronic acid (HA) of cultured human orbital fibroblasts (OFs) affected by interleukin-1 (IL-1), and their inhibitors interleukin-1 receptor antagonist(IL-1Ra).	Hyaluronic Acid	55-70	interleukin 1 alpha	Homo sapiens	147-151
14740552-1	2003	PURPOSE: To observe the proliferation and synthesis of hyaluronic acid (HA) of cultured human orbital fibroblasts (OFs) affected by interleukin-1 (IL-1), and their inhibitors interleukin-1 receptor antagonist(IL-1Ra).	Hyaluronic Acid	72-74	interleukin 1 alpha	Homo sapiens	132-145
14740552-1	2003	PURPOSE: To observe the proliferation and synthesis of hyaluronic acid (HA) of cultured human orbital fibroblasts (OFs) affected by interleukin-1 (IL-1), and their inhibitors interleukin-1 receptor antagonist(IL-1Ra).	Hyaluronic Acid	72-74	interleukin 1 alpha	Homo sapiens	147-151
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	76-79	interleukin 1 alpha	Homo sapiens	9-13
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	76-79	interleukin 1 alpha	Homo sapiens	115-119
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	163-166	interleukin 1 alpha	Homo sapiens	9-13
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	163-166	interleukin 1 alpha	Homo sapiens	115-119
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	163-166	interleukin 1 alpha	Homo sapiens	9-13
14740552-5	2003	RESULTS: IL-1(550,500 U/ml) can significantly increase the proliferation of OFs and synthesis of HA (P &lt; 0.05), IL-1 (500 U/ml) stimulate more proliferation of OFs and HA production of OFs from TAO patients than that of OFs from normal subjects.	ofs	163-166	interleukin 1 alpha	Homo sapiens	115-119
14740552-7	2003	IL1Ra (5.50 ng/ml) can block the proliferation and HA production of OFs when IL-1 with IL-1Ra incubated together.	ofs	68-71	interleukin 1 alpha	Homo sapiens	77-81
14708413-5	2003	The intravenous calcitriol treatment group showed significant decreases in levels of iPTH, TNF-alpha, IL-1 and IL-6 and a significant increase in total calcium level after 3 and 6 months.	Calcitriol	16-26	interleukin 1 alpha	Homo sapiens	102-106
14740444-5	2003	Thus, available steroid pre-hormones are rapidly converted to proinflammatory estrogens in the synovial tissue in the presence of inflammatory cytokines (i.e. TNF alpha, IL-1, IL-6).	Steroids	16-23	interleukin 1 alpha	Homo sapiens	170-174
14631115-4	2003	Using a recombinant IL-1alpha at 5 ng/ml, it was shown that IL-1alpha would upregulate, while IL-1Ra, an IL-1 receptor antagonist, would down-regulate the expression of IL-1alpha mRNA in MG2 cells, indicating the presence of an autostimulatory loop of IL-1alpha in these cells.	MG2	187-190	interleukin 1 alpha	Homo sapiens	20-29
14631115-4	2003	Using a recombinant IL-1alpha at 5 ng/ml, it was shown that IL-1alpha would upregulate, while IL-1Ra, an IL-1 receptor antagonist, would down-regulate the expression of IL-1alpha mRNA in MG2 cells, indicating the presence of an autostimulatory loop of IL-1alpha in these cells.	MG2	187-190	interleukin 1 alpha	Homo sapiens	60-69
14631115-4	2003	Using a recombinant IL-1alpha at 5 ng/ml, it was shown that IL-1alpha would upregulate, while IL-1Ra, an IL-1 receptor antagonist, would down-regulate the expression of IL-1alpha mRNA in MG2 cells, indicating the presence of an autostimulatory loop of IL-1alpha in these cells.	MG2	187-190	interleukin 1 alpha	Homo sapiens	60-69
14631115-4	2003	Using a recombinant IL-1alpha at 5 ng/ml, it was shown that IL-1alpha would upregulate, while IL-1Ra, an IL-1 receptor antagonist, would down-regulate the expression of IL-1alpha mRNA in MG2 cells, indicating the presence of an autostimulatory loop of IL-1alpha in these cells.	MG2	187-190	interleukin 1 alpha	Homo sapiens	60-69
14631115-6	2003	Recombinant IL-1alpha upregulated the expression of both MMP-9 and -13, and the induction of MMP-13 but not MMP-9 could be inhibited by SB203580, an inhibitor of p38.	SB 203580	136-144	interleukin 1 alpha	Homo sapiens	12-21
14631115-7	2003	Similarly, in primarily cultured human liver MFs, upregulation of MMP-1 by IL-1alpha was also shown to be inhibited by SB203580.	SB 203580	119-127	interleukin 1 alpha	Homo sapiens	75-84
14595591-6	2003	In addition, peyote extract induced up to 1.85-, 2.29- and 1.89-fold increases in mRNA signal of IL-1, IL-6 and IL-8 by human leukocytes.	Mescaline	13-19	interleukin 1 alpha	Homo sapiens	97-101
12951330-1	2003	Dexamethasone (DXM) interferes with the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) and can thereby diminish the secondary inflammatory response that follows initiation of antibacterial therapy.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	99-118
13679236-7	2003	Moxifloxacin inhibited the release of TNFalpha, IL-1, IL-6, and IL-8 in a concentration-dependent manner across a range of 0.004 to 4 microg/mL.	Moxifloxacin	0-12	interleukin 1 alpha	Homo sapiens	48-52
12951330-1	2003	Dexamethasone (DXM) interferes with the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) and can thereby diminish the secondary inflammatory response that follows initiation of antibacterial therapy.	Dexamethasone	15-18	interleukin 1 alpha	Homo sapiens	99-118
12746488-0	2003	S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.	Copper	21-27	interleukin 1 alpha	Homo sapiens	64-73
12957837-4	2003	Application of a novel liposome-based targeting method supports a critical involvement of brain macrophages, and their capacity to manifest induced prostanoid synthesis, in the interleukin-1-induced recruitment of control circuitry governing at least one acute phase response (hypothalamo-pituitary-adrenal axis activation), and suggests a two-way interaction between perivascular and endothelial cells in monitoring circulating cytokine signals.	Prostaglandins	148-158	interleukin 1 alpha	Homo sapiens	177-190
12915334-12	2003	In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase).	Fatty Acids, Omega-3	33-51	interleukin 1 alpha	Homo sapiens	141-145
12923654-10	2003	Incubation with IL-1alpha together with linoleic acid reduced the expression of ICAM-1 and VCAM-1 in contrast to palmitic acid.	Palmitic Acid	113-126	interleukin 1 alpha	Homo sapiens	16-25
12882799-3	2003	In different cells, IL-1alpha activates different signaling pathways, such as nuclear factor (NF)-kappaB-mediated protein expression, the phospholipase A(2) (PLA(2))-activated arachidonate cascade, and activator protein (AP)-1-associated transcription.	Arachidonic Acid	176-188	interleukin 1 alpha	Homo sapiens	20-29
12882799-8	2003	The effect of IL-1alpha was blocked by Go6976, a protein kinase C micro (PKC micro ) inhibitor; PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor; SB202190, a p38 inhibitor; and SR11302, an AP-1 inhibitor; but not by inhibitors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or sphingomyelinase.	Go 6976	39-45	interleukin 1 alpha	Homo sapiens	14-23
12882799-8	2003	The effect of IL-1alpha was blocked by Go6976, a protein kinase C micro (PKC micro ) inhibitor; PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor; SB202190, a p38 inhibitor; and SR11302, an AP-1 inhibitor; but not by inhibitors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or sphingomyelinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	96-103	interleukin 1 alpha	Homo sapiens	14-23
12882799-8	2003	The effect of IL-1alpha was blocked by Go6976, a protein kinase C micro (PKC micro ) inhibitor; PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor; SB202190, a p38 inhibitor; and SR11302, an AP-1 inhibitor; but not by inhibitors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or sphingomyelinase.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	164-172	interleukin 1 alpha	Homo sapiens	14-23
12882799-8	2003	The effect of IL-1alpha was blocked by Go6976, a protein kinase C micro (PKC micro ) inhibitor; PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor; SB202190, a p38 inhibitor; and SR11302, an AP-1 inhibitor; but not by inhibitors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or sphingomyelinase.	SR 11302	195-202	interleukin 1 alpha	Homo sapiens	14-23
12946945-2	2003	In this study, we demonstrate that Fas/FADD-induced MCP-1 upregulation is driven by an autocrine/paracrine signaling loop in which interleukin (IL)-1alpha synthesis and release are activated through caspase- and calpain-dependent processes.	ammonium ferrous sulfate	35-38	interleukin 1 alpha	Homo sapiens	131-154
12946945-4	2003	Both were increased greatly in response to Fas/FADD activation, primarily through an autocrine/paracrine pathway in which secreted IL-1alpha stimulated additional IL-1alpha synthesis and release.	ammonium ferrous sulfate	43-46	interleukin 1 alpha	Homo sapiens	131-140
12946945-4	2003	Both were increased greatly in response to Fas/FADD activation, primarily through an autocrine/paracrine pathway in which secreted IL-1alpha stimulated additional IL-1alpha synthesis and release.	ammonium ferrous sulfate	43-46	interleukin 1 alpha	Homo sapiens	163-172
12946945-10	2003	These data suggest that calpains play a dominant role in Fas/FADD-induced IL-1alpha release and MCP-1 upregulation and that caspase activation may function to amplify the effects of calpain activation.	ammonium ferrous sulfate	57-60	interleukin 1 alpha	Homo sapiens	74-83
12746488-3	2003	We report here that IL-1alpha is a Cu2+-binding protein and human U937 cells, like NIH 3T3 cells, release IL-1alpha in response to temperature stress in a Cu2+-dependent manner.	cupric ion	35-39	interleukin 1 alpha	Homo sapiens	20-29
17163923-6	2003	Possible mechanisms of phenol-induced pemphigus include the induction of IL-1alpha and TNF-alpha release by keratinocytes.	Phenol	23-29	interleukin 1 alpha	Homo sapiens	73-82
12846989-4	2003	Glial cells can release deleterious compounds such as proinflammatory cytokines (TNF-alpha, Il-1beta, IFN-gamma), which may act by stimulating nitric oxide production in glial cells, or which may exert a more direct deleterious effect on dopaminergic neurons by activating receptors that contain intracytoplasmic death domains involved in apoptosis.	Nitric Oxide	143-155	interleukin 1 alpha	Homo sapiens	92-100
12832092-4	2003	Binding of the Ab-conjugated PS liposomes containing 2 or 14 mol% 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol) 2000] (DSPE-PEG(2000)) to interleukin 1alpha stimulated human umbilical vein endothelial cells was 8- and 16-fold higher than those without conjugated Ab, respectively, based on the percentage relative increase in cell associated lipid for these liposomes.	Phosphatidylserines	29-31	interleukin 1 alpha	Homo sapiens	165-183
12832092-4	2003	Binding of the Ab-conjugated PS liposomes containing 2 or 14 mol% 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol) 2000] (DSPE-PEG(2000)) to interleukin 1alpha stimulated human umbilical vein endothelial cells was 8- and 16-fold higher than those without conjugated Ab, respectively, based on the percentage relative increase in cell associated lipid for these liposomes.	1,2-distearoylphosphatidylethanolamine	66-113	interleukin 1 alpha	Homo sapiens	165-183
12781508-2	2003	In general, most fluoroquinolone derivatives superinduce in-vitro interleukin 2 synthesis but inhibit synthesis of interleukin 1 and tumour necrosis factor (TNF)alpha; furthermore, they enhance significantly the synthesis of colony-stimulating factors (CSF).	Fluoroquinolones	17-32	interleukin 1 alpha	Homo sapiens	115-155
12806619-0	2003	IL-1alpha-induced COX-2 expression in human intestinal myofibroblasts is dependent on a PKCzeta-ROS pathway.	Reactive Oxygen Species	96-99	interleukin 1 alpha	Homo sapiens	0-9
12806619-6	2003	Single-cell fluorescence microscopy of 2",7"-dichlorofluorescin diacetate (DCF)-loaded cells showed that IL-1alpha increased ROS levels 2-fold within 15 minutes and this increase was inhibited by 10 micromol/L bisindolylymaleimide I (BIS), a pan-specific PKC inhibitor that also inhibits COX-2 expression.	diacetyldichlorofluorescein	39-73	interleukin 1 alpha	Homo sapiens	105-114
12806619-6	2003	Single-cell fluorescence microscopy of 2",7"-dichlorofluorescin diacetate (DCF)-loaded cells showed that IL-1alpha increased ROS levels 2-fold within 15 minutes and this increase was inhibited by 10 micromol/L bisindolylymaleimide I (BIS), a pan-specific PKC inhibitor that also inhibits COX-2 expression.	diacetyldichlorofluorescein	75-78	interleukin 1 alpha	Homo sapiens	105-114
12806619-6	2003	Single-cell fluorescence microscopy of 2",7"-dichlorofluorescin diacetate (DCF)-loaded cells showed that IL-1alpha increased ROS levels 2-fold within 15 minutes and this increase was inhibited by 10 micromol/L bisindolylymaleimide I (BIS), a pan-specific PKC inhibitor that also inhibits COX-2 expression.	Reactive Oxygen Species	125-128	interleukin 1 alpha	Homo sapiens	105-114
12806619-6	2003	Single-cell fluorescence microscopy of 2",7"-dichlorofluorescin diacetate (DCF)-loaded cells showed that IL-1alpha increased ROS levels 2-fold within 15 minutes and this increase was inhibited by 10 micromol/L bisindolylymaleimide I (BIS), a pan-specific PKC inhibitor that also inhibits COX-2 expression.	bisindolylymaleimide i	210-232	interleukin 1 alpha	Homo sapiens	105-114
12806619-6	2003	Single-cell fluorescence microscopy of 2",7"-dichlorofluorescin diacetate (DCF)-loaded cells showed that IL-1alpha increased ROS levels 2-fold within 15 minutes and this increase was inhibited by 10 micromol/L bisindolylymaleimide I (BIS), a pan-specific PKC inhibitor that also inhibits COX-2 expression.	1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester	234-237	interleukin 1 alpha	Homo sapiens	105-114
12806619-7	2003	Chelerythrine chloride (CC) (0.5 micromol/L) inhibited classic and novel PKC activity, but not PKCzeta, and enhanced IL-1alpha-mediated ROS generation 4.0-fold and COX-2 expression 1.8-fold.	chelerythrine	0-22	interleukin 1 alpha	Homo sapiens	117-126
12806619-7	2003	Chelerythrine chloride (CC) (0.5 micromol/L) inhibited classic and novel PKC activity, but not PKCzeta, and enhanced IL-1alpha-mediated ROS generation 4.0-fold and COX-2 expression 1.8-fold.	Reactive Oxygen Species	136-139	interleukin 1 alpha	Homo sapiens	117-126
12806619-12	2003	CONCLUSIONS: PKCzeta and threshold ROS generation are critical for IL-1alpha-induced COX-2 expression and act concomitantly with NF-kappaB translocation in IMF.	Reactive Oxygen Species	35-38	interleukin 1 alpha	Homo sapiens	67-76
12875365-6	2003	Exposure to hydrogen peroxide, followed by IL-1alpha, enhanced IL-8 production over that achieved with IL-1alpha alone.	Hydrogen Peroxide	12-29	interleukin 1 alpha	Homo sapiens	103-112
12798656-3	2003	Both animal and human studies have indicated that an increased intake of n-6 fatty acids from vegetable oils elevates prostaglandin E(2) levels as well as pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha.	Fatty Acids, Omega-6	73-88	interleukin 1 alpha	Homo sapiens	190-194
12856330-5	2003	IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma-mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines.	Serine	49-55	interleukin 1 alpha	Homo sapiens	0-30
12754378-2	2003	Because the Cu2+-binding proteins IL-1alpha and fibroblast growth factor 1 are exported into the extracellular compartment in a stress-dependent manner by using intracellular Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless polypeptides have been implicated as regulators of vascular injury in vivo, we examined the ability of Cu2+ chelation to repress neointimal thickening in response to injury.	cupric ion	12-16	interleukin 1 alpha	Homo sapiens	34-43
12754378-2	2003	Because the Cu2+-binding proteins IL-1alpha and fibroblast growth factor 1 are exported into the extracellular compartment in a stress-dependent manner by using intracellular Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless polypeptides have been implicated as regulators of vascular injury in vivo, we examined the ability of Cu2+ chelation to repress neointimal thickening in response to injury.	cupric ion	175-179	interleukin 1 alpha	Homo sapiens	34-43
12754378-2	2003	Because the Cu2+-binding proteins IL-1alpha and fibroblast growth factor 1 are exported into the extracellular compartment in a stress-dependent manner by using intracellular Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless polypeptides have been implicated as regulators of vascular injury in vivo, we examined the ability of Cu2+ chelation to repress neointimal thickening in response to injury.	cupric ion	175-179	interleukin 1 alpha	Homo sapiens	34-43
12754378-6	2003	Our data suggest that intracellular copper may be involved in mediating the response to injury in vivo by its ability to regulate the stress-induced release of IL-1alpha by using the nonclassical export mechanism employed by human peripheral blood mononuclear cells in vitro.	Copper	36-42	interleukin 1 alpha	Homo sapiens	160-169
12745101-9	2003	Multivariate linear regression analysis revealed that MIBG at 4 hours was independently associated with IL-1 levels (p &lt;0.001).	3-Iodobenzylguanidine	54-58	interleukin 1 alpha	Homo sapiens	104-108
12752101-2	2003	Cytosine to thymine transitions at codons -889 and -511 in the IL-1-alpha and IL-1-beta genes, respectively, and an 86-base pair repeat in the IL-1Ra are believed to influence gene transcription.	Thymine	12-19	interleukin 1 alpha	Homo sapiens	63-73
12751790-7	2003	We conclude that recruitment of IRAK to the IL-1RI is redox regulated by the glutathione system, a reduced status being a prerequisite for an appropiate IL-1 response.	Glutathione	77-88	interleukin 1 alpha	Homo sapiens	44-48
12719626-5	2003	We compared betaPP-5"-UTR activity in the presence of interleukin-1 (IL-1alpha and IL-1beta), transforming growth factor (TGF-beta1) and tumor necrosis factor TNF-alpha1.	betapp	12-18	interleukin 1 alpha	Homo sapiens	54-67
12719626-5	2003	We compared betaPP-5"-UTR activity in the presence of interleukin-1 (IL-1alpha and IL-1beta), transforming growth factor (TGF-beta1) and tumor necrosis factor TNF-alpha1.	betapp	12-18	interleukin 1 alpha	Homo sapiens	69-78
12719626-5	2003	We compared betaPP-5"-UTR activity in the presence of interleukin-1 (IL-1alpha and IL-1beta), transforming growth factor (TGF-beta1) and tumor necrosis factor TNF-alpha1.	betapp	12-18	interleukin 1 alpha	Homo sapiens	83-91
12856330-0	2003	IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.	Serine	43-49	interleukin 1 alpha	Homo sapiens	69-82
12856330-1	2003	Interleukin-1 (IL-1) induces the phosphorylation of Stat1 on serine 727 but not on tyrosine 701.	Serine	61-67	interleukin 1 alpha	Homo sapiens	0-13
12856330-1	2003	Interleukin-1 (IL-1) induces the phosphorylation of Stat1 on serine 727 but not on tyrosine 701.	Serine	61-67	interleukin 1 alpha	Homo sapiens	15-19
12752101-2	2003	Cytosine to thymine transitions at codons -889 and -511 in the IL-1-alpha and IL-1-beta genes, respectively, and an 86-base pair repeat in the IL-1Ra are believed to influence gene transcription.	Cytosine	0-8	interleukin 1 alpha	Homo sapiens	63-73
12927051-6	2003	In this review, we have summarized the experimental data available with regard to the involvement of the interleukin-1 system in kainic acid-induced changes in the brain and emphasized the modulatory role of interleukin-1beta in this model of epilepsy	Kainic Acid	129-140	interleukin 1 alpha	Homo sapiens	105-118
12830492-5	2003	In the recent years it was found that Tetracyclines (TC) decrease the levels of TNF-alpha, IL-1, Nitric Oxide, and prostaglandins, and via intra and extra cellular mechanisms inhibit the production and activation of the MMPs.	Tetracyclines	38-51	interleukin 1 alpha	Homo sapiens	91-95
12640658-8	2003	By quantitative assay, SA-beta gal activity is correlated with both tissue levels of Il-1alpha and the severity of BPH.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	23-25	interleukin 1 alpha	Homo sapiens	85-94
12640658-8	2003	By quantitative assay, SA-beta gal activity is correlated with both tissue levels of Il-1alpha and the severity of BPH.	(2-benzoylethyl)trimethylammonium	26-30	interleukin 1 alpha	Homo sapiens	85-94
12830492-5	2003	In the recent years it was found that Tetracyclines (TC) decrease the levels of TNF-alpha, IL-1, Nitric Oxide, and prostaglandins, and via intra and extra cellular mechanisms inhibit the production and activation of the MMPs.	Tetracyclines	53-55	interleukin 1 alpha	Homo sapiens	91-95
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	Cesium	0-2	interleukin 1 alpha	Homo sapiens	74-83
12576141-9	2003	Pretreatment with indomethacin, a cyclooxygenase inhibitor, blocked LPS and IL-1 induced neuronal activation in the PVN, but did not reduce the induction of IkappaBalpha in PVN endothelium.	Indomethacin	18-30	interleukin 1 alpha	Homo sapiens	76-80
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	ct	7-9	interleukin 1 alpha	Homo sapiens	74-83
12932292-1	2003	A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13.	triterpenoid TP-222	12-24	interleukin 1 alpha	Homo sapiens	154-173
12562711-2	2003	AmB-DOC produced dose-dependent increases in interleukin (IL)-1beta, IL-1alpha, tumour necrosis factor-alpha, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta at 2 h. HT-AmB induced cytokine and chemokine production at a lower level than those observed with corresponding concentrations of AmB-DOC, while retaining antifungal activity.	amphotericin B, deoxycholate drug combination	0-7	interleukin 1 alpha	Homo sapiens	69-78
12562711-2	2003	AmB-DOC produced dose-dependent increases in interleukin (IL)-1beta, IL-1alpha, tumour necrosis factor-alpha, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta at 2 h. HT-AmB induced cytokine and chemokine production at a lower level than those observed with corresponding concentrations of AmB-DOC, while retaining antifungal activity.	Amphotericin B	0-3	interleukin 1 alpha	Homo sapiens	69-78
12833683-2	2003	METHOD: Using immunohistochemical streptavidin-biotin peroxide complex (SABC) method to investigate the expression of interleukin-1 (IL-1), IL-8 and tumor necrosis factor (TNF) in the local mucosa of the two type chronic sinusitis.	sabc	72-76	interleukin 1 alpha	Homo sapiens	118-131
12619182-6	2003	In the alendronate treated group, statistically significant changes occurred in the levels of serum IL-1alpha and IL-6 after three months, and in IL-1beta, IL-6, IL-6r and TNF-alpha after six months (p &lt; 0.05).	Alendronate	7-18	interleukin 1 alpha	Homo sapiens	100-109
14515147-1	2003	In the retinoic acid-differentiated neuroblastoma SH-SY5Y cells, IL-1 induced binding activity of NFkappaB and up-regulated the expression and activity of MnSOD.	Tretinoin	7-20	interleukin 1 alpha	Homo sapiens	65-69
12932292-1	2003	A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	26-70	interleukin 1 alpha	Homo sapiens	154-173
12932292-1	2003	A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	72-76	interleukin 1 alpha	Homo sapiens	154-173
12932292-3	2003	To quantify the effects of CDDO on IL-1-induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	27-31	interleukin 1 alpha	Homo sapiens	35-39
12932292-5	2003	In SW-1353 cells, 300 nM CDDO significantly decreased the induction of MMP-1 and MMP-13 by IL-1.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	25-29	interleukin 1 alpha	Homo sapiens	91-95
12932292-6	2003	In human primary chondrocytes, 300 nM CDDO inhibited the induction of these genes by IL-1 to an even greater extent.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	38-42	interleukin 1 alpha	Homo sapiens	85-89
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 alpha	Homo sapiens	176-180
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 alpha	Homo sapiens	176-180
12932292-8	2003	In human primary chondrocytes, IL-1-induced Bcl-3 expression was inhibited when cells were pretreated with CDDO.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	107-111	interleukin 1 alpha	Homo sapiens	31-35
12849755-4	2003	Functionally, interleukin-1 has been shown to induce the release of serotonin (5-HT), a neurotransmitter known to potently affect aggression and rage behavior.	Serotonin	68-77	interleukin 1 alpha	Homo sapiens	14-27
12932292-11	2003	Furthermore, overexpressed Bcl-3 could sustain the CDDO-dependent inhibition of IL-1-induced MMP-1 expression.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	51-55	interleukin 1 alpha	Homo sapiens	80-84
12932292-12	2003	Our data demonstrate that CDDO inhibits IL-1-induced MMP-1 and MMP-13 expression in human chondrocytes.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	26-30	interleukin 1 alpha	Homo sapiens	40-44
12932292-13	2003	CDDO also inhibits the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	0-4	interleukin 1 alpha	Homo sapiens	47-51
12854882-10	2003	Biafine significantly reduced capillary alterations, restored CD34 expression as well as epithelial cell proliferation and significantly decreased collagen synthesis and IL-1 expression.	Biafine	0-7	interleukin 1 alpha	Homo sapiens	170-174
14756525-5	2003	We confirm that IL-1alpha is one of the primary mediators for matrix degradation released from keratinocytes after GA treatment.	glycolic acid	115-117	interleukin 1 alpha	Homo sapiens	16-25
12899535-1	2003	Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes.	Calcitriol	0-10	interleukin 1 alpha	Homo sapiens	123-136
12535959-1	2003	Single exposure to the proinflammatory cytokine interleukin-1 induces sensitization of the adrenocorticotropin hormone and corticosterone responses to stressors weeks later (hypothalamus-pituitary-adrenal sensitization).	Corticosterone	123-137	interleukin 1 alpha	Homo sapiens	48-61
12899535-1	2003	Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes.	Vitamin D	33-42	interleukin 1 alpha	Homo sapiens	123-136
12635941-2	2003	OBJECTIVE: To investigate the endogenous regulation of interleukin-1 (IL-1) cytokine network in osteoarthritic (OA) and rheumatoid (RA) cartilage in relation to nitric oxide (NO) production.	Nitric Oxide	161-173	interleukin 1 alpha	Homo sapiens	55-68
12509619-6	2003	RESULTS: A77 1726 inhibited the production of PGE(2) in synoviocytes activated by TNF-alpha and IL-1alpha with median inhibitory concentrations (IC(50)) of 7 and 3 microM respectively.	Prostaglandins E	46-49	interleukin 1 alpha	Homo sapiens	96-105
12635941-2	2003	OBJECTIVE: To investigate the endogenous regulation of interleukin-1 (IL-1) cytokine network in osteoarthritic (OA) and rheumatoid (RA) cartilage in relation to nitric oxide (NO) production.	Nitric Oxide	161-173	interleukin 1 alpha	Homo sapiens	70-74
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Nickel	33-39	interleukin 1 alpha	Homo sapiens	113-117
14708449-8	2003	RESULTS: Activation of lysosomal enzymes and increased synthesis of interleukin-1 by monocytes and mesangial cells were observed in patients with chronic alcoholism and renal diseases with testosterone deficiency and excess estradiol in the plasma.	Estradiol	224-233	interleukin 1 alpha	Homo sapiens	68-81
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Chromium	41-49	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	isoeugenol	51-61	interleukin 1 alpha	Homo sapiens	113-117
12729367-4	2003	It has been hypothesized that the link between cisplatin treatment and FMF attacks lies in an increased production of serotonin, IL-6, IL-1, IL-8 and TNF-alpha.	Cisplatin	47-56	interleukin 1 alpha	Homo sapiens	135-139
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Dinitrofluorobenzene	67-88	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	betaat	118-124	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Sodium Dodecyl Sulfate	229-251	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Polysorbates	253-261	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Acetic Acid	263-274	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Sodium Hydroxide	276-292	interleukin 1 alpha	Homo sapiens	113-117
20021188-3	2003	We have shown that the allergens nickel, chromium, isoeugenol, and dinitrofluoro benzene induce the secretion of IL-1 betaat levels that are two- to threefold higher than those of controls and that the nonallergens and irritants sodium dodecyl sulfate, Tween-20, acetic acid, sodium hydroxide, and dimethyl sulfoxide fail to induce such a response.	Dimethyl Sulfoxide	298-316	interleukin 1 alpha	Homo sapiens	113-117
12436048-14	2002	Further, these results demonstrate that acute alcohol is a potent inhibitor of NF-kappaB activation by mediators of early (LPS) or late (IL-1, TNF(alpha)) stages of inflammation in monocytes.	Alcohols	46-53	interleukin 1 alpha	Homo sapiens	137-141
12502025-0	2002	Interleukin 1alpha alters hippocampal serotonin and norepinephrine release during open-field behavior in Sprague-Dawley animals: differences from the Fawn-Hooded animal model of depression.	Serotonin	38-47	interleukin 1 alpha	Homo sapiens	0-18
12502025-0	2002	Interleukin 1alpha alters hippocampal serotonin and norepinephrine release during open-field behavior in Sprague-Dawley animals: differences from the Fawn-Hooded animal model of depression.	Norepinephrine	52-66	interleukin 1 alpha	Homo sapiens	0-18
12436048-0	2002	Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?	Alcohols	6-13	interleukin 1 alpha	Homo sapiens	120-133
12391149-7	2002	The proinflammatory cytokine interleukin 1 (IL-1) induced MKP-1 expression in a p38-dependent manner and acted synergistically with dexamethasone to induce MKP-1 expression.	Dexamethasone	132-145	interleukin 1 alpha	Homo sapiens	29-48
12436048-11	2002	Inhibition of NF-kappaB by acute alcohol was concomitant with decreased levels of the IkappaB(alpha) molecule in the cytoplasm of LPS, IL-1, and TNFalpha-activated monocytes.	Alcohols	33-40	interleukin 1 alpha	Homo sapiens	135-139
12445497-1	2002	This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells.	Prostaglandins E	116-131	interleukin 1 alpha	Homo sapiens	53-62
12445497-1	2002	This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells.	Prostaglandins E	136-139	interleukin 1 alpha	Homo sapiens	53-62
12621779-7	2002	In patients with CR the expression levels of TGF-beta, TNF-alpha and IL-1 mRNA were higher than in control group.	Chromium	17-19	interleukin 1 alpha	Homo sapiens	69-73
12445497-1	2002	This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells.	Prostaglandins E	195-198	interleukin 1 alpha	Homo sapiens	53-62
12445497-4	2002	Treatment with 0.5 ng/ml IL-1alpha resulted in a time-dependent increase in PGE(2) secretion with maximal secretion detected at 24 and 48 h after stimulation with IL-1alpha.	Dinoprostone	76-82	interleukin 1 alpha	Homo sapiens	25-34
12445497-4	2002	Treatment with 0.5 ng/ml IL-1alpha resulted in a time-dependent increase in PGE(2) secretion with maximal secretion detected at 24 and 48 h after stimulation with IL-1alpha.	Dinoprostone	76-82	interleukin 1 alpha	Homo sapiens	163-172
12445497-5	2002	Co-treatment of the cells with IL-1alpha and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1alpha mediated secretion of PGE(2).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	82-87	interleukin 1 alpha	Homo sapiens	102-111
12445497-5	2002	Co-treatment of the cells with IL-1alpha and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1alpha mediated secretion of PGE(2).	Prostaglandins E	134-137	interleukin 1 alpha	Homo sapiens	31-40
12445497-5	2002	Co-treatment of the cells with IL-1alpha and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1alpha mediated secretion of PGE(2).	Prostaglandins E	134-137	interleukin 1 alpha	Homo sapiens	102-111
12379548-4	2002	Melatonin was proinflammatory, causing significantly increased production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha at 4:00 P.M. and 4:00 A.M. in all subject groups (range, 12.8 +/- 3.3 to 131.72 +/- 16.4%, p &lt; or = 0.0003).	Melatonin	0-9	interleukin 1 alpha	Homo sapiens	77-90
12492814-7	2002	The stimulation by IL-1alpha up-regulated CD44, 49e, 51, 54, 61, 106 on MC on polystyrene; CD49e, 51, 61, 106, 146, 165 on MC on fibronectin, and CD49e, 51, 54 on MC grown on human matrix.	Polystyrenes	78-89	interleukin 1 alpha	Homo sapiens	19-28
12234873-0	2002	Inhibition of secretion of interleukin-1alpha and tumor necrosis factor alpha by the ketolide antibiotic telithromycin.	Ketolides	85-93	interleukin 1 alpha	Homo sapiens	27-45
12234873-0	2002	Inhibition of secretion of interleukin-1alpha and tumor necrosis factor alpha by the ketolide antibiotic telithromycin.	telithromycin	105-118	interleukin 1 alpha	Homo sapiens	27-45
12234873-1	2002	The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors.	telithromycin	15-28	interleukin 1 alpha	Homo sapiens	73-91
12234873-1	2002	The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors.	telithromycin	15-28	interleukin 1 alpha	Homo sapiens	93-102
12234873-2	2002	Secretion of each cytokine was significantly increased by LPS alone, whereas treatment with telithromycin significantly inhibited secretion of IL-1alpha and TNF-alpha but not secretion of IL-1beta, IL-6, and IL-10.	telithromycin	92-105	interleukin 1 alpha	Homo sapiens	143-152
12234873-3	2002	Telithromycin had immunomodulatory effects as a result of alteration of secretion of IL-1alpha and TNF-alpha by monocytes.	telithromycin	0-13	interleukin 1 alpha	Homo sapiens	85-94
12445219-6	2002	SNPs in the IL-1alpha (+ 4845) and IL-1beta (- 511, + 3954) genes were analyzed by amplifying the polymorphic region using polymerase chain reaction (PCR), followed by restriction-enzyme digestion and agarose gel electrophoresis.	Sepharose	201-208	interleukin 1 alpha	Homo sapiens	12-21
12356823-0	2002	Suppression of the TNFalpha-induced increase in IL-1alpha expression by hypochlorite in human corneal epithelial cells.	Hypochlorous Acid	72-84	interleukin 1 alpha	Homo sapiens	48-57
12356823-4	2002	The current study was undertaken to examine in immortalized human corneal epithelial cells whether NaOCl alters TNFalpha-induced increases in expression of IL-1alpha gene and protein.	Sodium Hypochlorite	99-104	interleukin 1 alpha	Homo sapiens	156-165
12356823-8	2002	RESULTS: Exposure to NaOCl (0.75 mM) for 10 minutes caused suppression of TNFalpha-induced increases in IL-1alpha mRNA and protein, declines in NFkappaB nuclear transfer, and a modification of IkappaBalpha, based on a bandshift detected by Western blot analysis.	Sodium Hypochlorite	21-26	interleukin 1 alpha	Homo sapiens	104-113
12356823-13	2002	These effects suggest that release of HClO/OCl(-) in vivo by activated neutrophils may counterbalance TNFalpha-induced NFkappaB-dependent secretion if IL-1alpha and suppress an excessive inflammatory reaction.	Hypochlorous Acid	38-42	interleukin 1 alpha	Homo sapiens	151-160
12356823-13	2002	These effects suggest that release of HClO/OCl(-) in vivo by activated neutrophils may counterbalance TNFalpha-induced NFkappaB-dependent secretion if IL-1alpha and suppress an excessive inflammatory reaction.	ocl	43-46	interleukin 1 alpha	Homo sapiens	151-160
12232838-3	2002	However, exposure of human brain endothelial cells (HBECs) to tumor necrosis factor (TNF) and/or interleukin (IL)-1 markedly up-regulates Stx receptor (globotriaosylceramide; Gb3) expression and cytotoxicity.	globotriaosylceramide	152-173	interleukin 1 alpha	Homo sapiens	97-115
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Dinoprostone	38-54	interleukin 1 alpha	Homo sapiens	141-145
12351711-6	2002	Modification of cysteine residues inserted at positions 137 in IL1, 277 in IL2, and 441 in IL4 also led to inactivation, and at positions 157 in IL1 and 532 in IL5, cysteine was modified without an effect on binding activity.	Cysteine	16-24	interleukin 1 alpha	Homo sapiens	63-66
12351711-6	2002	Modification of cysteine residues inserted at positions 137 in IL1, 277 in IL2, and 441 in IL4 also led to inactivation, and at positions 157 in IL1 and 532 in IL5, cysteine was modified without an effect on binding activity.	Cysteine	16-24	interleukin 1 alpha	Homo sapiens	145-148
12351711-6	2002	Modification of cysteine residues inserted at positions 137 in IL1, 277 in IL2, and 441 in IL4 also led to inactivation, and at positions 157 in IL1 and 532 in IL5, cysteine was modified without an effect on binding activity.	Cysteine	165-173	interleukin 1 alpha	Homo sapiens	63-66
12421568-1	2002	Interleukin-1 (IL-1) is a multifunctional cytokine known to act as a growth factor for AIDS-KS cells.	Potassium	92-94	interleukin 1 alpha	Homo sapiens	0-13
12421568-1	2002	Interleukin-1 (IL-1) is a multifunctional cytokine known to act as a growth factor for AIDS-KS cells.	Potassium	92-94	interleukin 1 alpha	Homo sapiens	15-19
12421568-2	2002	In addition to its mitogenic effects, we found that IL-1 induced the protection of KS cells from apoptotic death induced by serum deprivation in a dose-dependent manner.	Potassium	83-85	interleukin 1 alpha	Homo sapiens	52-56
12421568-3	2002	AIDS-KS cells as well as cells derived from iatrogenic and sporadic KS exhibited a similar response to IL-1, which stresses the key role of this cytokine in the pathogenesis of KS regardless of its epidemiological form.	Potassium	5-7	interleukin 1 alpha	Homo sapiens	103-107
12421568-5	2002	The effects of IL-1 were inhibited by IL-1ra, suggesting that imbalance between these two counter-acting cytokines may contribute to the altered accumulation of KS spindle cells.	Potassium	161-163	interleukin 1 alpha	Homo sapiens	15-19
12218154-2	2002	The goal of this study was to elucidate whether alprazolam modulates IL-1alpha-initiated responses.	Alprazolam	48-58	interleukin 1 alpha	Homo sapiens	69-78
12218154-4	2002	We found that alprazolam inhibited IL-1alpha-elicited MCP-1 production within a range of 0.1-3 micro M. In contrast, it did not inhibit IL-1alpha-induced IL-8 production.	Alprazolam	14-24	interleukin 1 alpha	Homo sapiens	35-44
12218154-8	2002	While AP-1 is involved in regulating the IL-1alpha-induced expression of IL-8, but not MCP-1, alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe.	Alprazolam	94-104	interleukin 1 alpha	Homo sapiens	41-50
12218154-8	2002	While AP-1 is involved in regulating the IL-1alpha-induced expression of IL-8, but not MCP-1, alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe.	Oligonucleotides	156-171	interleukin 1 alpha	Homo sapiens	41-50
12218154-9	2002	These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region.	Alprazolam	81-91	interleukin 1 alpha	Homo sapiens	42-51
12218154-9	2002	These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region.	Alprazolam	81-91	interleukin 1 alpha	Homo sapiens	221-230
12218154-9	2002	These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region.	Alprazolam	191-201	interleukin 1 alpha	Homo sapiens	42-51
12607189-6	2002	RESULTS: Histamine increased the production of IL-1, IL-6 and IL-8, and ICAM-1 expression.	Histamine	9-18	interleukin 1 alpha	Homo sapiens	47-51
12607189-8	2002	The antiH-1, emedastine, significantly reduced H-induced production of IL-1, IL-6 and IL-8, while azelastine reduced only IL-1.	emedastine	13-23	interleukin 1 alpha	Homo sapiens	71-75
12607189-8	2002	The antiH-1, emedastine, significantly reduced H-induced production of IL-1, IL-6 and IL-8, while azelastine reduced only IL-1.	azelastine	98-108	interleukin 1 alpha	Homo sapiens	122-126
12351711-6	2002	Modification of cysteine residues inserted at positions 137 in IL1, 277 in IL2, and 441 in IL4 also led to inactivation, and at positions 157 in IL1 and 532 in IL5, cysteine was modified without an effect on binding activity.	Cysteine	165-173	interleukin 1 alpha	Homo sapiens	145-148
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Dinoprostone	38-54	interleukin 1 alpha	Homo sapiens	184-188
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Dinoprostone	56-60	interleukin 1 alpha	Homo sapiens	141-145
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Dinoprostone	56-60	interleukin 1 alpha	Homo sapiens	184-188
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Nitric Oxide	94-106	interleukin 1 alpha	Homo sapiens	141-145
14989423-3	2002	This accounts for the large amount of prostaglandin-E2 (PGE2), platelet activating factor and nitric oxide (NO) produced by cells exposed to IL-1 or in animals or humans injected with IL-1.	Nitric Oxide	94-106	interleukin 1 alpha	Homo sapiens	184-188
14989424-3	2002	IL-1 and TNFalpha are potent inducers of matrix metalloproteinases (MMPs), eicosanoids, nitric oxide oxydase (iNOS), receptor activator of NF-kappaB ligand (RANKL), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption.	Eicosanoids	75-86	interleukin 1 alpha	Homo sapiens	0-17
14989426-3	2002	A higher ratio of IL-1Ra:IL-1 production by the peripheral blood mononuclear cells (PBMC) of RA patients successfully treated with methotrexate (MTX) is observed when compared with the PBMC of untreated patients or healthy controls.	Methotrexate	131-143	interleukin 1 alpha	Homo sapiens	18-22
14989426-3	2002	A higher ratio of IL-1Ra:IL-1 production by the peripheral blood mononuclear cells (PBMC) of RA patients successfully treated with methotrexate (MTX) is observed when compared with the PBMC of untreated patients or healthy controls.	Methotrexate	145-148	interleukin 1 alpha	Homo sapiens	18-22
12405690-0	2002	Effect of glucosamine on interleukin-1-conditioned articular cartilage.	Glucosamine	10-21	interleukin 1 alpha	Homo sapiens	25-38
12405690-1	2002	Glucosamine inhibits recombinant human interleukin-1 stimulated cartilage degradation in equine cartilage explants.	Glucosamine	0-11	interleukin 1 alpha	Homo sapiens	39-52
12375739-0	2002	Inhibitory effect of Artemisia capillaris on ethanol-induced cytokines (TNF-alpha, IL-1alpha) secretion in Hep G2 cells.	Ethanol	45-52	interleukin 1 alpha	Homo sapiens	83-92
12427115-4	2002	Ambroxol significantly attenuated the production of superoxide, hydrogen peroxide, HOCl, and nitric oxide in fMLP- or IL-1-activated phagocytic cells, while the inhibitory effects of antiinflammatory and thiol compounds were only observed in HOCl production.	Ambroxol	0-8	interleukin 1 alpha	Homo sapiens	118-122
12427115-4	2002	Ambroxol significantly attenuated the production of superoxide, hydrogen peroxide, HOCl, and nitric oxide in fMLP- or IL-1-activated phagocytic cells, while the inhibitory effects of antiinflammatory and thiol compounds were only observed in HOCl production.	Nitric Oxide	93-105	interleukin 1 alpha	Homo sapiens	118-122
12192055-1	2002	IkappaB kinase gamma (IKKgamma) (also known as NEMO, Fip-3, and IKKAP-1) is the essential regulatory component of the IKK complex; it is required for NF-kappaB activation by various stimuli, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), phorbol esters, lipopolysaccharides, and double-stranded RNA.	Phorbol Esters	264-278	interleukin 1 alpha	Homo sapiens	242-261
12375739-3	2002	AC (0.5-5 microg/mL) inhibited the secretion of EtOH-induced interluekin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha).	Actinium	0-2	interleukin 1 alpha	Homo sapiens	81-90
12375739-3	2002	AC (0.5-5 microg/mL) inhibited the secretion of EtOH-induced interluekin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha).	Ethanol	48-52	interleukin 1 alpha	Homo sapiens	81-90
12375739-4	2002	AC also inhibited the EtOH-, IL-1alpha-, and TNF-alpha-induced cytotoxicity.	Actinium	0-2	interleukin 1 alpha	Homo sapiens	29-38
12176706-2	2002	We recently published a case-control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1alpha (IL-1alpha), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor alpha (TNFalpha) as risk factors associated with silicosis, a fibrotic lung disease.	Silicon Dioxide	82-88	interleukin 1 alpha	Homo sapiens	141-159
12151017-7	2002	This review discusses the potential involvement of extracellular ATP and P2X7 receptors as regulators of interleukin-1-mediated neuropathologies and thus as a mediator of cell death following pathological insults.	Adenosine Triphosphate	65-68	interleukin 1 alpha	Homo sapiens	105-118
12080324-6	2002	Moreover, troglitazone treatment increased the expression of interleukin-1 alpha, a multifunctional cytokine implicated in antitumor immunity.	Troglitazone	10-22	interleukin 1 alpha	Homo sapiens	61-80
12087084-9	2002	These data suggest that MMP-1 may play a significant role in the degradation of extracellular collagen types I and III in the pregnant uterine cervix during the process of cervical ripening, in response to various stimulations such as PGF(2alpha), IL-1alpha and mechanical stretch.	Prostaglandins F	235-238	interleukin 1 alpha	Homo sapiens	248-257
11940570-6	2002	To examine the molecular mechanism for LPS induction of IL-1 in macrophages, we demonstrated that LPS quickly stimulated reactive oxygen species (ROS), and 3 h later induced prointerleukin-1 beta (pro-IL-1, precursor of IL-1) production and IL-1 secretion.	Reactive Oxygen Species	121-144	interleukin 1 alpha	Homo sapiens	56-60
11940570-6	2002	To examine the molecular mechanism for LPS induction of IL-1 in macrophages, we demonstrated that LPS quickly stimulated reactive oxygen species (ROS), and 3 h later induced prointerleukin-1 beta (pro-IL-1, precursor of IL-1) production and IL-1 secretion.	Reactive Oxygen Species	146-149	interleukin 1 alpha	Homo sapiens	56-60
11940570-7	2002	LPS stimulated pro-IL-1 message/protein between 3 and 10 h; however, there was a 40% reduction of pro-IL-1 in preincubation of the antioxidant, N-acetylcysteine (NAC).	Acetylcysteine	144-160	interleukin 1 alpha	Homo sapiens	102-106
11940570-7	2002	LPS stimulated pro-IL-1 message/protein between 3 and 10 h; however, there was a 40% reduction of pro-IL-1 in preincubation of the antioxidant, N-acetylcysteine (NAC).	Acetylcysteine	162-165	interleukin 1 alpha	Homo sapiens	102-106
11940570-8	2002	Moreover, NAC moderated LPS-induced IL-1 secretion partially via interleukin 1-converting enzyme.	Acetylcysteine	10-13	interleukin 1 alpha	Homo sapiens	36-40
11940570-11	2002	Furthermore, the pharmacological antagonists LY294002, SB203580, curcumin, calphostin C, and PD98059 revealed the diverse roles of LPS-mediated protein kinases in pro-IL-1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	93-100	interleukin 1 alpha	Homo sapiens	167-171
11940570-12	2002	On the other hand, NAC and diphenyleneiodonium chloride partially inhibited LPS-induced Rac activity and protein-tyrosine kinase (PTK), indicating that LPS-mediated ROS and NADPH oxidase correspond to Rac activation and IL-1 expression.	Acetylcysteine	19-22	interleukin 1 alpha	Homo sapiens	220-224
11940570-12	2002	On the other hand, NAC and diphenyleneiodonium chloride partially inhibited LPS-induced Rac activity and protein-tyrosine kinase (PTK), indicating that LPS-mediated ROS and NADPH oxidase correspond to Rac activation and IL-1 expression.	diphenyleneiodonium	27-55	interleukin 1 alpha	Homo sapiens	220-224
11940570-12	2002	On the other hand, NAC and diphenyleneiodonium chloride partially inhibited LPS-induced Rac activity and protein-tyrosine kinase (PTK), indicating that LPS-mediated ROS and NADPH oxidase correspond to Rac activation and IL-1 expression.	Reactive Oxygen Species	165-168	interleukin 1 alpha	Homo sapiens	220-224
12115185-4	2002	RESULTS: Supplementation with n-3 PUFA (but not other fatty acids) reduced, in a dose-dependent manner, the endogenous and IL-1-induced release of proteoglycan metabolites from articular cartilage explants and specifically abolished endogenous aggrecanase and collagenase proteolytic activity.	Fatty Acids, Omega-3	30-38	interleukin 1 alpha	Homo sapiens	123-127
12195700-4	2002	Similarly, release of interleukin (IL)-1 alpha, IL-1 beta and tumor necrosis factor (TNF)-alpha from plasmin-stimulated PM was concentration-dependently inhibited by ciglitazone, but not by clofibric acid, while the LPS-induced TNF-alpha release remained unaffected by any of both PPAR agonists.	ciglitazone	166-177	interleukin 1 alpha	Homo sapiens	22-46
12101275-8	2002	IL-1-induced inhibition of IL-6 signaling was not mediated by the activation of tyrosine phosphatases or by p38-dependent activation of phospholipase A(2) or cyclooxygenases, which could lead to indirect inhibition via production of prostaglandins.	Prostaglandins	233-247	interleukin 1 alpha	Homo sapiens	0-4
11940570-0	2002	Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.	Reactive Oxygen Species	28-51	interleukin 1 alpha	Homo sapiens	97-110
12160520-8	2002	Addition of PGJ2 had an inhibitory effect on IL-1, IL-6 and TNFalpha secretion, while increasing IL-1Ra production.	9-deoxy-delta-9-prostaglandin D2	12-16	interleukin 1 alpha	Homo sapiens	45-49
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	fucan	24-29	interleukin 1 alpha	Homo sapiens	93-140
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	Dextrans	31-38	interleukin 1 alpha	Homo sapiens	93-140
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	Heparin	56-63	interleukin 1 alpha	Homo sapiens	93-140
12176706-2	2002	We recently published a case-control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1alpha (IL-1alpha), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor alpha (TNFalpha) as risk factors associated with silicosis, a fibrotic lung disease.	Silicon Dioxide	82-88	interleukin 1 alpha	Homo sapiens	161-170
12051868-2	2002	In the cycling endometrium, interleukin-1alpha activity is controlled by sex steroids and is confined to the perimenstrual phase, where it is involved in the events leading to tissue lysis and menstruation.	Steroids	77-85	interleukin 1 alpha	Homo sapiens	28-46
12102660-0	2002	Effect of skin barrier competence on SLS and water-induced IL-1alpha expression.	Water	45-50	interleukin 1 alpha	Homo sapiens	59-68
12102660-3	2002	In this study, we have determined the mRNA levels of IL-1alpha in the epidermis after topical application of sodium dodecyl sulphate (SLS) in both a commercially available epidermal kit (EpiDerm) and in excised skin.	Sodium Dodecyl Sulfate	109-132	interleukin 1 alpha	Homo sapiens	53-62
12102660-4	2002	Furthermore, we have determined the effect of water, the vehicle for SLS, on IL-1alpha mRNA levels.	Water	46-51	interleukin 1 alpha	Homo sapiens	77-86
12102660-5	2002	Topical application of water to excised skin increases IL-1alpha mRNA levels sixfold in the epidermis whereas topical application of water to EpiDerm cultures did not alter IL-1alpha mRNA levels.	Water	23-28	interleukin 1 alpha	Homo sapiens	55-64
12102660-9	2002	An additional increase in IL-1alpha mRNA levels observed between topical application of water and SLS is similar (about threefold) in both experimental systems.	Water	88-93	interleukin 1 alpha	Homo sapiens	26-35
12056850-3	2002	The recombinant human interleukin-1alpha (rhIL-1alpha, 5 ng/ml) was added to induce proteoglycan (PG) degradation and the degree of PG degradation was assessed by measuring the amount of glycosaminoglycan (GAG) released into the culture medium.	Glycosaminoglycans	187-204	interleukin 1 alpha	Homo sapiens	22-40
12102660-13	2002	Our results show clearly that the topical application of water to excised skin results in increased levels of IL-1alpha mRNA in the epidermis.	Water	57-62	interleukin 1 alpha	Homo sapiens	110-119
12040027-4	2002	IL-1 increased SP-A expression in lung type II cells and had additive stimulatory effects with cAMP.	Cyclic AMP	95-99	interleukin 1 alpha	Homo sapiens	0-4
12040027-5	2002	Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-kappaB consensus and TBE probes; cAMP and IL-1 had additive effects.	Cyclic AMP	22-26	interleukin 1 alpha	Homo sapiens	135-139
12040027-5	2002	Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-kappaB consensus and TBE probes; cAMP and IL-1 had additive effects.	tbe	114-117	interleukin 1 alpha	Homo sapiens	31-35
12040027-5	2002	Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-kappaB consensus and TBE probes; cAMP and IL-1 had additive effects.	Cyclic AMP	126-130	interleukin 1 alpha	Homo sapiens	31-35
12040027-8	2002	Bt2cAMP increased binding to NF-kappaB and TBE probes more slowly; no changes in nuclear levels of p50, p65, or TTF-1 were evident, suggesting that IL-1 and cAMP act by different mechanisms.	tbe	43-46	interleukin 1 alpha	Homo sapiens	148-152
11994489-4	2002	MSUM and CPPD dose-dependently stimulated the production of PGE(2) in hOB as assessed by enzyme immunoassay, a response that was synergistically enhanced in the presence of IL-1.	Calcium Pyrophosphate	9-13	interleukin 1 alpha	Homo sapiens	173-177
11994489-4	2002	MSUM and CPPD dose-dependently stimulated the production of PGE(2) in hOB as assessed by enzyme immunoassay, a response that was synergistically enhanced in the presence of IL-1.	Dinoprostone	60-66	interleukin 1 alpha	Homo sapiens	173-177
12037399-9	2002	The effect of calcitriol was maximal at 10(-7) to 10(-9) and noneffective at 10(-11) M. Calcitriol diminished the secretion of IL-1, TNF-alpha, and MG-CSF in PBMC.	Calcitriol	14-24	interleukin 1 alpha	Homo sapiens	127-131
12011469-2	2002	We find parallel selectivity at a cellular level; acetaminophen inhibits PGHS activity with an IC(50) of 4.3 microM in interleukin (IL)-1 alpha-stimulated human umbilical vein endothelial cells, in contrast with an IC(50) of 1,870 microM for the platelet, with 2 microM arachidonic acid as substrate.	Acetaminophen	50-63	interleukin 1 alpha	Homo sapiens	119-143
12037399-9	2002	The effect of calcitriol was maximal at 10(-7) to 10(-9) and noneffective at 10(-11) M. Calcitriol diminished the secretion of IL-1, TNF-alpha, and MG-CSF in PBMC.	Calcitriol	88-98	interleukin 1 alpha	Homo sapiens	127-131
11953890-3	2002	Treatment of HT-29 cells with the nitric oxide donor Deta NONOate (50 nM) as well as induction of nitric oxide synthase II mRNA and production of endogenous nitric oxide by inflammatory cytokines (IFN-gamma and IL-1alpha) increased the invasiveness of HT-29 cells by approximately 40% and 75%, respectively.	Nitric Oxide	34-46	interleukin 1 alpha	Homo sapiens	211-220
12020969-4	2002	Treatment with SB203580, a specific inhibitor of p38 mitogen-activated protein kinases (MAPK), potently inhibited IL-1-mediated induction of iNOS and TNFalpha in cultures of human fetal astrocytes.	SB 203580	15-23	interleukin 1 alpha	Homo sapiens	114-118
12575354-4	2002	RESULTS: The IL-1 production by PBMC of RA, either in the medium alone (spontaneously) or in the presence of lipopolysacchride (LPS) stimulation, was suppressed by 99Tc-MDP; and the sIL-2R by PBMC of RA, either in the medium alone (spontaneously) or in the presence of phytohemagglutinin (PHA) induction, was inhibited by 99Tc-MDP.	99mTc-Methylene diphosphonate	164-172	interleukin 1 alpha	Homo sapiens	13-17
12575354-4	2002	RESULTS: The IL-1 production by PBMC of RA, either in the medium alone (spontaneously) or in the presence of lipopolysacchride (LPS) stimulation, was suppressed by 99Tc-MDP; and the sIL-2R by PBMC of RA, either in the medium alone (spontaneously) or in the presence of phytohemagglutinin (PHA) induction, was inhibited by 99Tc-MDP.	99mTc-Methylene diphosphonate	322-330	interleukin 1 alpha	Homo sapiens	13-17
12575354-5	2002	CONCLUSION: 99Tc-MDP acts on PBMC and a possible immune activity by 99Tc-MDP is related to the suppression of IL-1 and sIL-2R in RA patients.	99mTc-Methylene diphosphonate	12-20	interleukin 1 alpha	Homo sapiens	110-114
12575354-5	2002	CONCLUSION: 99Tc-MDP acts on PBMC and a possible immune activity by 99Tc-MDP is related to the suppression of IL-1 and sIL-2R in RA patients.	99mTc-Methylene diphosphonate	68-76	interleukin 1 alpha	Homo sapiens	110-114
12005365-5	2002	Under the stimulation of IL-1alpha, heparinoid increased the production of TIMP-3 in a concentration-dependent manner, but not TIMP-1, TIMP-2, MMP-1 or MMP-3.	Heparinoids	36-46	interleukin 1 alpha	Homo sapiens	25-34
12575354-3	2002	The levels of IL-1 and sIL-2R from PBMC affected by 99Tc-MDP were determined with enzyme linked immunosorbert assays (ELISA).	99mTc-Methylene diphosphonate	52-60	interleukin 1 alpha	Homo sapiens	14-18
12575354-4	2002	RESULTS: The IL-1 production by PBMC of RA, either in the medium alone (spontaneously) or in the presence of lipopolysacchride (LPS) stimulation, was suppressed by 99Tc-MDP; and the sIL-2R by PBMC of RA, either in the medium alone (spontaneously) or in the presence of phytohemagglutinin (PHA) induction, was inhibited by 99Tc-MDP.	lipopolysacchride	109-126	interleukin 1 alpha	Homo sapiens	13-17
11953974-10	2002	Although IL-1alpha alone did not significantly increase PGE(2) production, significant PGE(2) superinduction occurred in cartilage stimulated with IL-1alpha and the NOS2 inhibitor 1400W compared with stimulation with IL-1alpha alone in hypoxia, but not in normoxia.	Prostaglandins E	87-90	interleukin 1 alpha	Homo sapiens	147-156
11880271-2	2002	One major effect of IL-1 is the increased release of eicosanoid mediators via induction of cyclooxygenase-2 (COX-2).	Eicosanoids	53-63	interleukin 1 alpha	Homo sapiens	20-24
11953974-10	2002	Although IL-1alpha alone did not significantly increase PGE(2) production, significant PGE(2) superinduction occurred in cartilage stimulated with IL-1alpha and the NOS2 inhibitor 1400W compared with stimulation with IL-1alpha alone in hypoxia, but not in normoxia.	Prostaglandins E	87-90	interleukin 1 alpha	Homo sapiens	147-156
11953974-10	2002	Although IL-1alpha alone did not significantly increase PGE(2) production, significant PGE(2) superinduction occurred in cartilage stimulated with IL-1alpha and the NOS2 inhibitor 1400W compared with stimulation with IL-1alpha alone in hypoxia, but not in normoxia.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	180-185	interleukin 1 alpha	Homo sapiens	9-18
11835156-0	2002	Effects of DMAEMA and 4-methoxyphenol on gingival fibroblast growth, metabolism, and response to interleukin-1.	mequinol	22-37	interleukin 1 alpha	Homo sapiens	97-110
12147043-8	2002	Moreover, compared to chlorpromazine, the lower IL-1alpha release observed with 6-methylcoumarin and ofloxacin could be linked to their weak phototoxic potential.	6-methylcoumarin	80-96	interleukin 1 alpha	Homo sapiens	48-57
11918718-8	2002	EPA treatment results in higher TNF-alpha and IL-1alpha expression, both in nonirradiated and UVB-irradiated keratinocytes.	Eicosapentaenoic Acid	0-3	interleukin 1 alpha	Homo sapiens	46-55
11927397-0	2002	Nitric oxide is involved in interleukin-1alpha-induced cytotoxicity in polarised human thyrocytes.	Nitric Oxide	0-12	interleukin 1 alpha	Homo sapiens	28-46
11918718-0	2002	Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes.	Eicosapentaenoic Acid	0-21	interleukin 1 alpha	Homo sapiens	92-101
11918718-0	2002	Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes.	Fatty Acids, Omega-3	25-55	interleukin 1 alpha	Homo sapiens	92-101
12147043-8	2002	Moreover, compared to chlorpromazine, the lower IL-1alpha release observed with 6-methylcoumarin and ofloxacin could be linked to their weak phototoxic potential.	Ofloxacin	101-110	interleukin 1 alpha	Homo sapiens	48-57
12068797-3	2002	The presence of interleukin-1 in the perfusion system, as a model for inflammatory cytokine effects, enhanced the overall amounts of released prostacyclin but did not affect the production of endothelin-1.	Epoprostenol	142-154	interleukin 1 alpha	Homo sapiens	16-29
11998897-4	2002	We show here, using IL-1alpha stimulation to simulate autoinduction, that administration of GLA to healthy volunteers and to patients with inflammatory arthritis reduces LPS-induced IL-1beta secretion mainly by reducing autoinduction of IL-1beta.	gamma-Linolenic Acid	92-95	interleukin 1 alpha	Homo sapiens	20-29
11874235-8	2002	Interleukin-1alpha (IL-1alpha) and interferon gamma (IFN-gamma) but not tumor necrosis factor alpha (TNF-alpha) also significantly increased nitrotyrosine expression in these cells.	3-nitrotyrosine	141-154	interleukin 1 alpha	Homo sapiens	0-18
11874235-8	2002	Interleukin-1alpha (IL-1alpha) and interferon gamma (IFN-gamma) but not tumor necrosis factor alpha (TNF-alpha) also significantly increased nitrotyrosine expression in these cells.	3-nitrotyrosine	141-154	interleukin 1 alpha	Homo sapiens	20-29
11963834-3	2002	Prostaglandin E2 (PGE2) secretion from amnion-derived WISH cells was assessed using enzyme-linked immunosorbent assay after stimulation by cyclic mechanical stretching and interleukin-1 (IL-1).	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	172-185
11963834-3	2002	Prostaglandin E2 (PGE2) secretion from amnion-derived WISH cells was assessed using enzyme-linked immunosorbent assay after stimulation by cyclic mechanical stretching and interleukin-1 (IL-1).	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	187-191
11963834-3	2002	Prostaglandin E2 (PGE2) secretion from amnion-derived WISH cells was assessed using enzyme-linked immunosorbent assay after stimulation by cyclic mechanical stretching and interleukin-1 (IL-1).	Dinoprostone	18-22	interleukin 1 alpha	Homo sapiens	172-185
11963834-8	2002	In an in vitro study, cyclic mechanical stretching significantly enhanced IL-1-augmented PGE2 secretion from WISH cells.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	74-78
12018979-3	2002	Since interleukin-1 and tumor necrosis factor are the principal polypeptide mediators of immunoregulation, reduced production of these cytokines by dietary supplementation with omega-3, may be a possible mechanism for the treatment of chronic fatigue syndrome.	Fatty Acids, Omega-3	177-184	interleukin 1 alpha	Homo sapiens	6-45
12226929-11	2002	Progesterone and 17 beta-estradiol downregulated costimulatory proliferative activity of IL-1 alpha or beta.	Progesterone	0-12	interleukin 1 alpha	Homo sapiens	89-99
11935498-3	2002	An increase in haptoglobin is induced by cytocines like IL-6 und IL-1.	cytocines	41-50	interleukin 1 alpha	Homo sapiens	65-69
11915555-2	2002	Fever mediators are mainly derived from the host cells and are pyrogenous cytokines such as interleukin-1, tumour necrosis factor alpha, interleukin-6 or interferons which act at the hypothalamus level via prostaglandin E2.	Dinoprostone	206-222	interleukin 1 alpha	Homo sapiens	92-135
11846032-6	2002	In response to interleukin-1, chondrocytes upregulate the production of nitric oxide and prostaglandin E2, two factors that have been shown to induce a number of the cellular changes associated with OA.	Dinoprostone	89-105	interleukin 1 alpha	Homo sapiens	15-28
11906497-5	2002	Treatment of LPS-stimulated monocytes with moxifloxacin significantly inhibited (P &lt; 0.01) secretion of IL-1alpha by monocytes of each of 10 human donors; the secretion of TNF-alpha was significantly inhibited (P &lt; 0.01) in monocytes from six of 10 donors.	Moxifloxacin	43-55	interleukin 1 alpha	Homo sapiens	107-116
11906497-8	2002	CONCLUSIONS: Moxifloxacin has immunomodulatory activity through its capacity to alter the secretion of IL-1alpha and TNF-alpha by human monocytes.	Moxifloxacin	13-25	interleukin 1 alpha	Homo sapiens	103-112
11882700-3	2002	This study shows that treatment of human intestinal epithelial T84 cells with Etx induces expression of IL-6, IL-10, IL-1R antagonist, as well as IL-1alpha and IL-1beta and low levels of IL-8.	2-ethoxyethanol	78-81	interleukin 1 alpha	Homo sapiens	146-155
11844650-3	2002	RESULTS: Estrogen, statins, and PUFAs enhance nitric oxide synthesis, suppress the production of proinflammatory cytokines such as tumor necrosis factor(alpha), interleukin-1, interleukin-2, and interleukin-6, show antioxidant-like and antiatherosclerotic properties, have neuroprotective actions, and by themselves or their products inhibit tumor cell proliferation and improve osteoporosis.	Fatty Acids, Unsaturated	32-37	interleukin 1 alpha	Homo sapiens	161-174
12653178-14	2002	Similarly, the stimulation of the vagus nerve may inhibit TNF synthesis in the liver and acetylecholine, the principal vagal neurotransmitter, significantly attenuates the release of pro-inflammatory cytokines TNF-alpha, interleukin 1,6 and 18, but not the anti-inflammatory cytokine IL-10 in experiments.	acetylecholine	89-103	interleukin 1 alpha	Homo sapiens	221-243
11846032-6	2002	In response to interleukin-1, chondrocytes upregulate the production of nitric oxide and prostaglandin E2, two factors that have been shown to induce a number of the cellular changes associated with OA.	Nitric Oxide	72-84	interleukin 1 alpha	Homo sapiens	15-28
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	SB 203580	182-190	interleukin 1 alpha	Homo sapiens	43-47
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	195-202	interleukin 1 alpha	Homo sapiens	43-47
12226929-11	2002	Progesterone and 17 beta-estradiol downregulated costimulatory proliferative activity of IL-1 alpha or beta.	Estradiol	17-34	interleukin 1 alpha	Homo sapiens	89-99
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	Acetylcysteine	234-251	interleukin 1 alpha	Homo sapiens	43-47
11754748-7	2002	PD98059, a specific inhibitor of the ERK-activating kinase MEK1, also abolished the effects of IL-1alpha on ERK activation and osteoclast survival.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 alpha	Homo sapiens	95-104
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	pyrrolidine dithiocarbamic acid	256-283	interleukin 1 alpha	Homo sapiens	43-47
11752025-11	2002	Dimethyl-thio-urea significantly inhibited the LPS-, IL-1-, and PMA-induced GM-CSF production.	1,3-dimethylthiourea	0-18	interleukin 1 alpha	Homo sapiens	53-57
11752025-14	2002	ROS also partially mediate the effects of PMA and IL-1 on podocyte GM-CSF production.	ros	0-3	interleukin 1 alpha	Homo sapiens	50-54
12907838-6	2002	We have shown that the posterior division of the septum (PDS) plays a key role in mediating the effects of interleukin-1alpha (IL-1alpha) on memory.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	57-60	interleukin 1 alpha	Homo sapiens	107-125
12415617-0	2002	Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells.	Etoposide	56-65	interleukin 1 alpha	Homo sapiens	0-19
12415617-4	2002	The present investigation demonstrated that IL-1 alpha dramatically increased the sensitivity of MG-63, SAOS-2, and TE-85 osteosarcoma cells to etoposide when the two agents were used simultaneously.	Magnesium	97-99	interleukin 1 alpha	Homo sapiens	44-54
12415617-4	2002	The present investigation demonstrated that IL-1 alpha dramatically increased the sensitivity of MG-63, SAOS-2, and TE-85 osteosarcoma cells to etoposide when the two agents were used simultaneously.	Etoposide	144-153	interleukin 1 alpha	Homo sapiens	44-54
12415617-5	2002	The cytostatic activity of 1 microM etoposide was increased from 35 to 70%, 30 to 65%, and 4 to 90%, respectively, by 5.0 U/ml IL-1 alpha.	Etoposide	36-45	interleukin 1 alpha	Homo sapiens	127-137
12415617-8	2002	IL-1 alpha also increased the sensitivity of these cells to doxorubicin but not to cisplatin or topotecan.	Doxorubicin	60-71	interleukin 1 alpha	Homo sapiens	0-10
12907838-6	2002	We have shown that the posterior division of the septum (PDS) plays a key role in mediating the effects of interleukin-1alpha (IL-1alpha) on memory.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	57-60	interleukin 1 alpha	Homo sapiens	127-136
12907838-7	2002	Furthermore, this effect at the PDS is largely mediated by circulating IL-1alpha acting directly at the PDS which, in turn, depends on the ability of IL-1alpha to cross the BBB.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	32-35	interleukin 1 alpha	Homo sapiens	71-80
12907838-7	2002	Furthermore, this effect at the PDS is largely mediated by circulating IL-1alpha acting directly at the PDS which, in turn, depends on the ability of IL-1alpha to cross the BBB.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	32-35	interleukin 1 alpha	Homo sapiens	150-159
12907838-7	2002	Furthermore, this effect at the PDS is largely mediated by circulating IL-1alpha acting directly at the PDS which, in turn, depends on the ability of IL-1alpha to cross the BBB.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	104-107	interleukin 1 alpha	Homo sapiens	71-80
12907838-7	2002	Furthermore, this effect at the PDS is largely mediated by circulating IL-1alpha acting directly at the PDS which, in turn, depends on the ability of IL-1alpha to cross the BBB.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	104-107	interleukin 1 alpha	Homo sapiens	150-159
11739499-9	2001	Finally, we demonstrate that, in normal Th2 cells, stimulation with IL-1 leads to a rapid induction in tyrosine phosphorylation of several substrates including Lck itself.	Tyrosine	103-111	interleukin 1 alpha	Homo sapiens	68-72
15526538-6	2002	The potent proinflammatory cytokines IL-1 and TNFalpha and also IL-8 and IFNalpha,gamma stimulate cells in different tissues to release harmful proteinases and reactive oxygen species, contributing to tissue damage.	Reactive Oxygen Species	160-183	interleukin 1 alpha	Homo sapiens	37-41
11753986-0	2001	Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor.	Tyrosine	29-37	interleukin 1 alpha	Homo sapiens	117-135
11753986-14	2001	(2) Interleukin-1alpha and EGF significantly increased OVCA tyrosine phosphorylation, ezrin translocation, and cell growth.	Tyrosine	60-68	interleukin 1 alpha	Homo sapiens	4-22
11753986-18	2001	Interleukin-1alpha and EGF may regulate OVCA invasive behavior by activating ezrin tyrosine phosphorylation, translocation, and cancer cell proliferation.	Tyrosine	83-91	interleukin 1 alpha	Homo sapiens	0-18
12537603-8	2002	Serum and BALF IL-1 as well as BALF TNF-alpha were negatively correlated to PaO2/FiO2 (all P &lt; 0.05).	pao2	76-80	interleukin 1 alpha	Homo sapiens	15-19
11775008-10	2001	Both PGE2 and PGF2alpha production were significantly increased by treatment with IL-1alpha and C6-ceramide as compared with IL-1alpha treatment alone.	Dinoprost	14-23	interleukin 1 alpha	Homo sapiens	82-91
11775008-10	2001	Both PGE2 and PGF2alpha production were significantly increased by treatment with IL-1alpha and C6-ceramide as compared with IL-1alpha treatment alone.	N-caproylsphingosine	96-107	interleukin 1 alpha	Homo sapiens	125-134
11775008-0	2001	Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells.	Dinoprostone	80-96	interleukin 1 alpha	Homo sapiens	22-40
11817651-3	2001	Decidual activation and production of interleukin-1, tumour necrosis factor-alpha and epidermal growth factor enhance prostaglandin production in both the amnion and chorion, and also in the myometrium.	Prostaglandins	118-131	interleukin 1 alpha	Homo sapiens	38-81
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Dinoprostone	79-83	interleukin 1 alpha	Homo sapiens	40-49
11775008-2	2001	Our objective was to evaluate interleukin (IL)-1alpha-induced production of PGE2 and PGF2alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues.	Dinoprostone	76-80	interleukin 1 alpha	Homo sapiens	30-53
11775008-2	2001	Our objective was to evaluate interleukin (IL)-1alpha-induced production of PGE2 and PGF2alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues.	Dinoprost	85-94	interleukin 1 alpha	Homo sapiens	30-53
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Dinoprost	88-97	interleukin 1 alpha	Homo sapiens	40-49
11775008-2	2001	Our objective was to evaluate interleukin (IL)-1alpha-induced production of PGE2 and PGF2alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues.	Ceramides	155-163	interleukin 1 alpha	Homo sapiens	30-53
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Sphingomyelins	131-144	interleukin 1 alpha	Homo sapiens	40-49
11775008-8	2001	PGF2alpha production was further increased by treatment with the combination of IL-1alpha and C2-ceramide as compared with IL-1alpha treatment alone.	Dinoprost	0-9	interleukin 1 alpha	Homo sapiens	80-89
11775008-8	2001	PGF2alpha production was further increased by treatment with the combination of IL-1alpha and C2-ceramide as compared with IL-1alpha treatment alone.	Dinoprost	0-9	interleukin 1 alpha	Homo sapiens	123-132
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Ceramides	145-153	interleukin 1 alpha	Homo sapiens	40-49
11775008-10	2001	Both PGE2 and PGF2alpha production were significantly increased by treatment with IL-1alpha and C6-ceramide as compared with IL-1alpha treatment alone.	Dinoprostone	5-9	interleukin 1 alpha	Homo sapiens	82-91
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Ceramides	176-184	interleukin 1 alpha	Homo sapiens	40-49
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Dinoprostone	234-238	interleukin 1 alpha	Homo sapiens	40-49
11775008-13	2001	CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium.	Dinoprost	243-252	interleukin 1 alpha	Homo sapiens	40-49
11737207-0	2001	Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha-induced NF-kappaB activation.	Genistein	14-23	interleukin 1 alpha	Homo sapiens	59-77
11717138-0	2001	Interleukin 1 upregulates ovarian prostaglandin endoperoxide synthase-2 expression: evidence for prostaglandin-dependent/ceramide-independent transcriptional stimulation and for message stabilization.	prostaglandin-dependent	97-120	interleukin 1 alpha	Homo sapiens	0-13
11717138-0	2001	Interleukin 1 upregulates ovarian prostaglandin endoperoxide synthase-2 expression: evidence for prostaglandin-dependent/ceramide-independent transcriptional stimulation and for message stabilization.	Ceramides	121-129	interleukin 1 alpha	Homo sapiens	0-13
11737207-3	2001	In the present study, we found that genistein, a tyrosine kinase inhibitor, augmented IL-1alpha-dependent NF-kappaB activation, suggesting the presence of a tyrosine kinase mediating a suppression signal on NF-kappaB.	Genistein	36-45	interleukin 1 alpha	Homo sapiens	86-95
11737207-4	2001	As determined by luciferase reporter gene assay using kappaB-responsive element, genistein enhanced IL-1alpha-induced NF-kappaB activation.	Genistein	81-90	interleukin 1 alpha	Homo sapiens	100-109
11737207-9	2001	Moreover, genistein enhanced the IL-1alpha-dependent degradation of IkappaBalpha.	Genistein	10-19	interleukin 1 alpha	Homo sapiens	33-42
11764219-1	2001	OBJECTIVE: Interleukin 1 receptor antagonist (IL-1Ra) may play an important role in cartilage degradation by inhibiting IL-1 activity and therefore blocking IL-1 stimulation of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	177-193	interleukin 1 alpha	Homo sapiens	46-50
11764219-15	2001	Finally, the 3 NSAID reduced the levels of PGE2 detected after stimulation with IL-1.	Dinoprostone	43-47	interleukin 1 alpha	Homo sapiens	80-84
11764219-1	2001	OBJECTIVE: Interleukin 1 receptor antagonist (IL-1Ra) may play an important role in cartilage degradation by inhibiting IL-1 activity and therefore blocking IL-1 stimulation of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	195-199	interleukin 1 alpha	Homo sapiens	46-50
11606496-1	2001	BACKGROUND &amp; AIMS: Interleukin (IL)-1 gene cluster proinflammatory polymorphisms have been associated with development of gastric atrophy and with increased risk of gastric carcinoma.	Adenosine Monophosphate	12-15	interleukin 1 alpha	Homo sapiens	23-41
11546664-1	2001	We have examined the mechanisms regulating prostacyclin (PGI(2)) synthesis after acute exposure of human umbilical vein endothelial cells (HUVEC) to interleukin-1 alpha (IL-1 alpha).	Epoprostenol	43-55	interleukin 1 alpha	Homo sapiens	149-168
11546664-1	2001	We have examined the mechanisms regulating prostacyclin (PGI(2)) synthesis after acute exposure of human umbilical vein endothelial cells (HUVEC) to interleukin-1 alpha (IL-1 alpha).	Epoprostenol	43-55	interleukin 1 alpha	Homo sapiens	170-180
11546664-1	2001	We have examined the mechanisms regulating prostacyclin (PGI(2)) synthesis after acute exposure of human umbilical vein endothelial cells (HUVEC) to interleukin-1 alpha (IL-1 alpha).	Epoprostenol	57-63	interleukin 1 alpha	Homo sapiens	149-168
11546664-2	2001	IL-1 alpha evoked an early (30 min) release of PGI(2) and [(3)H]arachidonate that was blocked by the cytosolic phospholipase A(2)alpha (cPLA(2)alpha) inhibitor arachidonyl trifluoromethyl ketone.	Prostaglandins I	47-50	interleukin 1 alpha	Homo sapiens	0-10
11546664-2	2001	IL-1 alpha evoked an early (30 min) release of PGI(2) and [(3)H]arachidonate that was blocked by the cytosolic phospholipase A(2)alpha (cPLA(2)alpha) inhibitor arachidonyl trifluoromethyl ketone.	[(3)h]arachidonate	58-76	interleukin 1 alpha	Homo sapiens	0-10
11546664-2	2001	IL-1 alpha evoked an early (30 min) release of PGI(2) and [(3)H]arachidonate that was blocked by the cytosolic phospholipase A(2)alpha (cPLA(2)alpha) inhibitor arachidonyl trifluoromethyl ketone.	arachidonyltrifluoromethane	160-194	interleukin 1 alpha	Homo sapiens	0-10
11546664-3	2001	IL-1 alpha-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2; p42/p44(mapk)) coincided temporally with phosphorylation of cPLA(2)alpha and with the onset of PGI(2) synthesis.	Prostaglandins I	180-183	interleukin 1 alpha	Homo sapiens	0-10
11546664-4	2001	The mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors, PD-98059 and U-0126, blocked IL-1 alpha-induced ERK activation and partially attenuated cPLA(2)alpha phosphorylation and PGI(2) release, suggesting that ERK-dependent and -independent pathways regulate cPLA(2)alpha phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	69-77	interleukin 1 alpha	Homo sapiens	98-108
11546664-4	2001	The mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors, PD-98059 and U-0126, blocked IL-1 alpha-induced ERK activation and partially attenuated cPLA(2)alpha phosphorylation and PGI(2) release, suggesting that ERK-dependent and -independent pathways regulate cPLA(2)alpha phosphorylation.	U 0126	82-88	interleukin 1 alpha	Homo sapiens	98-108
11546664-4	2001	The mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors, PD-98059 and U-0126, blocked IL-1 alpha-induced ERK activation and partially attenuated cPLA(2)alpha phosphorylation and PGI(2) release, suggesting that ERK-dependent and -independent pathways regulate cPLA(2)alpha phosphorylation.	Epoprostenol	190-196	interleukin 1 alpha	Homo sapiens	98-108
11737818-17	2001	There was a significant increase in IL-1alpha and a directional increase in IL-8 levels in adult skin sites treated with the irritant, sodium lauryl sulfate, even in the absence of visible skin irritation (erythema).	Sodium Dodecyl Sulfate	135-156	interleukin 1 alpha	Homo sapiens	36-45
11546664-5	2001	SB-203580 treatment enhanced IL-1 alpha-induced MEK, p42/44(mapk), and cPLA(2)alpha phosphorylation but reduced thrombin-stimulated MEK and p42/44(mapk) activation.	SB 203580	0-9	interleukin 1 alpha	Homo sapiens	29-39
11546664-7	2001	These results show that IL-1 alpha causes an acute upregulation of PGI(2) generation in HUVEC, establish a role for the MEK/ERK/cPLA(2)alpha pathway in this early release, and provide evidence for an agonist-specific cross talk between p38(mapk) and p42/44(mapk) that may reflect receptor-specific differences in the signaling elements proximal to MAPK activation.	Epoprostenol	67-73	interleukin 1 alpha	Homo sapiens	24-34
11676825-11	2001	In human dermal fibroblasts that were stimulated with tumor necrosis factor alpha to reach high interleukin-1 expression levels, glybenclamide similarly suppressed interleukin-8.	Glyburide	129-142	interleukin 1 alpha	Homo sapiens	96-109
11564822-5	2001	More importantly, the suppressive effect of adenosine and CGS-21680 on IL-12 production was significantly enhanced in cells pretreated with either IL-1 (10 U/ml) or TNF-alpha (100 U/ml) but markedly attenuated in cells pretreated with IFN-gamma (100 U/ml).	Adenosine	44-53	interleukin 1 alpha	Homo sapiens	71-75
11564822-5	2001	More importantly, the suppressive effect of adenosine and CGS-21680 on IL-12 production was significantly enhanced in cells pretreated with either IL-1 (10 U/ml) or TNF-alpha (100 U/ml) but markedly attenuated in cells pretreated with IFN-gamma (100 U/ml).	cysteinylglycine	58-61	interleukin 1 alpha	Homo sapiens	71-75
11564822-6	2001	Similarly, IL-1 and TNF-alpha treatment potentiated the stimulatory effect of adenosine and CGS-21680 on IL-10 production, whereas IFN-gamma treatment almost completely abolished this effect.	Adenosine	78-87	interleukin 1 alpha	Homo sapiens	11-15
11676825-15	2001	These results are consistent with glybenclamide preventing externalization of interleukin-1 and subsequent autocrine induction of interleukin-8 in human dermal fibroblasts.	Glyburide	34-47	interleukin 1 alpha	Homo sapiens	78-91
11564822-6	2001	Similarly, IL-1 and TNF-alpha treatment potentiated the stimulatory effect of adenosine and CGS-21680 on IL-10 production, whereas IFN-gamma treatment almost completely abolished this effect.	cysteinylglycine	92-95	interleukin 1 alpha	Homo sapiens	11-15
11699474-10	2001	CONCLUSION: IL-1 alpha and IL-1 beta appear to have critical and non-redundant roles in the generation and regulation of potent IgG2 responses, which appear to be important in human responses to carbohydrate-bearing bacteria.	Carbohydrates	195-207	interleukin 1 alpha	Homo sapiens	12-22
11564822-7	2001	CGS-21680 stimulated an increase in intracellular cAMP in a time- and dose-dependent manner in IL-1- and TNF-alpha-treated cells but not in control or IFN-gamma-treated cells.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	0-9	interleukin 1 alpha	Homo sapiens	95-99
11564822-7	2001	CGS-21680 stimulated an increase in intracellular cAMP in a time- and dose-dependent manner in IL-1- and TNF-alpha-treated cells but not in control or IFN-gamma-treated cells.	Cyclic AMP	50-54	interleukin 1 alpha	Homo sapiens	95-99
11590220-9	2001	More importantly, TNF and IL-1 decreased the uptake of HDL cholesteryl ester into Hep3B cells.	Cholesterol Esters	59-76	interleukin 1 alpha	Homo sapiens	26-30
11683039-4	2001	Moreover, HaCaT keratinocytes were incubated with mizolastine under various UV treatment modalities in vitro to study its effect on the release of inflammatory cytokines, i.e. interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha (TNF-alpha).	mizolastine	50-61	interleukin 1 alpha	Homo sapiens	176-200
29537532-10	2001	CONCLUSION: IL-1alpha and IL-1beta appear to have critical and nonredundant roles in the generation and regulation of potent IgG2 responses, which appear to be important in human responses to carbohydrate-bearing bacteria.	Carbohydrates	192-204	interleukin 1 alpha	Homo sapiens	12-21
11574667-8	2001	This IL-1alpha-augmented MMP-1 secretion was partially but significantly blocked by an NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	110-144	interleukin 1 alpha	Homo sapiens	5-14
11683039-7	2001	An inhibitory effect in vitro of 10 nM mizolastine upon UV-induced cytokine release from HaCaT keratinocytes was observed for IL-1 alpha at 24 h after 10 J/cm2 UVA1, for IL-6 at 48 h after 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, and also for TNF-alpha at 4 h after 10 J/cm2 UVA, 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, respectively.	mizolastine	39-50	interleukin 1 alpha	Homo sapiens	126-136
11513350-5	2001	In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta.	celastrol	32-41	interleukin 1 alpha	Homo sapiens	162-170
11525637-8	2001	MNC chemotactic activity of conditioned medium of HUVEC stimulated with IL-1alpha or IFN-gamma was inhibited by co-treatment with sIL-6R.	sil-6r	130-136	interleukin 1 alpha	Homo sapiens	72-81
11517438-2	2001	Exposure of HUVECs to ethanol (0.01%-1%) dose-dependently inhibited (by 12%-27%) the release of stem cell factor, granulocyte-macrophage and granulocyte colony-stimulating factors (CSFs), or interleukin (IL)-8, but not of macrophage CSF triggered by lipopolysaccharide (LPS) or IL-1.	Ethanol	22-29	interleukin 1 alpha	Homo sapiens	278-282
11592370-0	2001	Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.	Nitric Oxide	91-103	interleukin 1 alpha	Homo sapiens	0-42
11592370-0	2001	Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.	Dinoprostone	108-124	interleukin 1 alpha	Homo sapiens	0-42
11592385-8	2001	RESULTS: Triptolide suppressed the IL-1alpha-induced production of proMMPs 1 and 3 and decreased their messenger RNA levels in human synovial fibroblasts.	triptolide	9-19	interleukin 1 alpha	Homo sapiens	35-44
11519352-0	2001	[Nitric oxide as main effector in the interleukin-1 system in ovulation].	Nitric Oxide	1-13	interleukin 1 alpha	Homo sapiens	38-51
11592385-9	2001	In contrast, the IL-1alpha-induced gene expression and production of TIMPs 1 and 2 were further augmented by triptolide in the synovial cells.	triptolide	109-119	interleukin 1 alpha	Homo sapiens	17-26
11592385-10	2001	Triptolide also inhibited the IL-1alpha-induced production of PGE2 by selectively suppressing the gene expression and production of COX-2, but not those of COX-1.	triptolide	0-10	interleukin 1 alpha	Homo sapiens	30-39
11592385-10	2001	Triptolide also inhibited the IL-1alpha-induced production of PGE2 by selectively suppressing the gene expression and production of COX-2, but not those of COX-1.	Dinoprostone	62-66	interleukin 1 alpha	Homo sapiens	30-39
11592385-13	2001	CONCLUSION: We have demonstrated for the first time that the therapeutic effects of TWHF in RA are due in part to the novel chondroprotective effect of triptolide via the direct suppression of the production of proMMPs 1 and 3 and the simultaneous up-regulation of TIMPs in IL-1-treated synovial fibroblasts.	triptolide	152-162	interleukin 1 alpha	Homo sapiens	274-278
11527941-9	2001	A strong positive correlation was observed between the intensity of corneal fluorescein staining and the tear fluid IL-1 alpha concentration (r(2) = 0.17, P &lt; 0.02) and the mature-to-precursor IL-1 beta ratio (r(2) = 0.46, P &lt; 0.001).	Fluorescein	76-87	interleukin 1 alpha	Homo sapiens	116-126
11517293-0	2001	Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro.	Estradiol	139-149	interleukin 1 alpha	Homo sapiens	167-171
11517293-3	2001	The present study shows that interleukin-1 (IL-1) induces interleukin-8 (IL-8) secretion by endometriotic cells and that oestradiol enhances endometriotic cell responsiveness to IL-1.	Estradiol	121-131	interleukin 1 alpha	Homo sapiens	178-182
11522381-8	2001	However, BP treatment of HaCaT keratinocytes resulted in a dose-dependent increase in IL-1alpha gene expression whereas no changes in IL-8 mRNA levels were observed.	Benzoyl Peroxide	9-11	interleukin 1 alpha	Homo sapiens	86-95
11415991-0	2001	Differential effects of estradiol on the adrenocorticotropin responses to interleukin-6 and interleukin-1 in the monkey.	Estradiol	24-33	interleukin 1 alpha	Homo sapiens	92-105
11519352-4	2001	IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability.	Prostaglandins	88-101	interleukin 1 alpha	Homo sapiens	0-4
11519352-4	2001	IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability.	Progesterone	106-118	interleukin 1 alpha	Homo sapiens	0-4
11519352-4	2001	IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability.	Glycosaminoglycans	167-184	interleukin 1 alpha	Homo sapiens	0-4
11519352-5	2001	The principal effector of the IL-1 system is nitric oxide.	Nitric Oxide	45-57	interleukin 1 alpha	Homo sapiens	30-34
12594868-6	2001	High alcohol concentrations exert an immunosuppressive effect on production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1.	Alcohols	5-12	interleukin 1 alpha	Homo sapiens	139-152
11523298-2	2001	Aceclofenac has an outstanding anti-inflammatory profile, involving besides a classical inhibition of prostaglandins E2, a decrease in the expression of several cytokines including interleukin 1 and tumor necrosis factor alpha.	aceclofenac	0-11	interleukin 1 alpha	Homo sapiens	181-226
11443200-3	2001	The IL-1alpha-induced PTHrP production was inhibited by PG H synthetase (Cox) inhibitors, indomethacin, and also by Cox-2 inhibitor, NS398.	Indomethacin	90-102	interleukin 1 alpha	Homo sapiens	4-13
11443200-3	2001	The IL-1alpha-induced PTHrP production was inhibited by PG H synthetase (Cox) inhibitors, indomethacin, and also by Cox-2 inhibitor, NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	133-138	interleukin 1 alpha	Homo sapiens	4-13
11443200-7	2001	These results suggest that induction of PGE(2) by IL-1alpha may be an important component of the PTHrP production of the inflammatory process in synovial tissues from patients with RA.	Prostaglandins E	40-43	interleukin 1 alpha	Homo sapiens	50-59
11404470-0	2001	Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.	phenserine	0-10	interleukin 1 alpha	Homo sapiens	87-100
11404470-9	2001	These studies suggest that phenserine reduces Abeta levels by regulating betaAPP translation via the recently described iron regulatory element in the 5"-untranslated region of betaAPP mRNA, which has been shown previously to be up-regulated in the presence of interleukin-1.	phenserine	27-37	interleukin 1 alpha	Homo sapiens	261-274
11404470-9	2001	These studies suggest that phenserine reduces Abeta levels by regulating betaAPP translation via the recently described iron regulatory element in the 5"-untranslated region of betaAPP mRNA, which has been shown previously to be up-regulated in the presence of interleukin-1.	Iron	120-124	interleukin 1 alpha	Homo sapiens	261-274
11378323-7	2001	We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF.	Sodium Chloride	20-24	interleukin 1 alpha	Homo sapiens	94-103
11368781-10	2001	In addition, we observed that forskolin potentiated and prolonged the IL-1-induced IkappaBalpha mRNA levels, whereas it did not stabilize the IkappaBalpha mRNA message.	Colforsin	30-39	interleukin 1 alpha	Homo sapiens	70-74
11368781-11	2001	Wholly, these studies indicate that elevated cAMP antagonizes IL-1-induced M-CSF transcription by up-regulating IkappaBalpha gene induction and its consequent attenuation of NF-kappaB activation.	Cyclic AMP	45-49	interleukin 1 alpha	Homo sapiens	62-66
11337199-5	2001	Many of the behavioural changes seen in depression are simulated by three pro-inflammatory cytokines (IL-1, IL-6 and TNF-alpha), which may produce their impact on the brain by activating cyclooxygenase, nitric acid synthase and corticotrophin releasing factor.	Nitric Acid	203-214	interleukin 1 alpha	Homo sapiens	102-106
11397831-2	2001	Recent studies in the rodent and in the primate have shown that the HPA responses to endotoxin and IL-1 were enhanced by gonadectomy and attenuated by estradiol (E2) replacement.	Estradiol	151-160	interleukin 1 alpha	Homo sapiens	99-103
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	benzyloxycarbonyl-phe-ala-fluoromethylketone	54-98	interleukin 1 alpha	Homo sapiens	145-154
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	z-fa	100-104	interleukin 1 alpha	Homo sapiens	145-154
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	FMK	105-108	interleukin 1 alpha	Homo sapiens	145-154
11368781-1	2001	We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression.	Colforsin	252-261	interleukin 1 alpha	Homo sapiens	31-49
11368781-1	2001	We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression.	Colforsin	252-261	interleukin 1 alpha	Homo sapiens	51-60
11368781-1	2001	We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression.	Cyclic AMP	265-269	interleukin 1 alpha	Homo sapiens	31-49
11368781-1	2001	We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression.	Cyclic AMP	265-269	interleukin 1 alpha	Homo sapiens	51-60
12600086-12	2001	CONCLUSION: These results indicated that the expression of A2bAR mRNAs in PBMCs was more remarkable in asthmatics than in healthy subjects; that adenosine or IL-1 potentiated the mRNA expression of A2bAR in PBMCs in asthmatic patients, which was correlated with allergy state and the degree of airway obstruction; and that theophylline might antagonize adenosine by inhibiting A2bAR mRNA.	Theophylline	323-335	interleukin 1 alpha	Homo sapiens	158-162
12600086-12	2001	CONCLUSION: These results indicated that the expression of A2bAR mRNAs in PBMCs was more remarkable in asthmatics than in healthy subjects; that adenosine or IL-1 potentiated the mRNA expression of A2bAR in PBMCs in asthmatic patients, which was correlated with allergy state and the degree of airway obstruction; and that theophylline might antagonize adenosine by inhibiting A2bAR mRNA.	Adenosine	353-362	interleukin 1 alpha	Homo sapiens	158-162
11378323-7	2001	We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF.	Sodium Chloride	20-24	interleukin 1 alpha	Homo sapiens	149-158
11403500-4	2001	In the presence of iloprost, both lymphocyte adhesion and IL-1 stimulated expression of ICAM-1 and ELAM-1 exhibited a significant reduction, while unstimulated adhesion molecule expression was not significantly affected.	Iloprost	19-27	interleukin 1 alpha	Homo sapiens	58-62
11292691-7	2001	The mechanism by which monocytes induce TFA in bacterium-infected EC was partly mediated by the proinflammatory cytokine interleukin-1 produced by the cells during coculture.	Trifluoroacetic Acid	40-43	interleukin 1 alpha	Homo sapiens	121-134
11359392-8	2001	HgCl2 also stimulated the release of low levels of tumour necrosis factor-alpha and interleukin-8 (but not RANTES), and inhibited the release of interleukin-1alpha by oral keratinocytes.	Mercuric Chloride	0-5	interleukin 1 alpha	Homo sapiens	145-163
11352890-5	2001	Increased release of AA in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely insensitive to inhibitors of phospholipases A(2) and C. Iron-overloaded cardiomyocytes also displayed increased production of eicosanoids and induction of cyclooxygenase-2 after stimulation with interleukin-1alpha.	Iron	27-31	interleukin 1 alpha	Homo sapiens	320-338
11108714-5	2001	Interleukin-1 (IL-1) appears to mediate dsRNA + IFN-gamma-induced islet damage in a nitric oxide-dependent manner, as the interleukin-1 receptor antagonist protein prevents dsRNA + IFN-gamma-induced iNOS expression, inhibition of insulin secretion, and islet degeneration.	Nitric Oxide	84-96	interleukin 1 alpha	Homo sapiens	0-13
11399092-9	2001	IL-1 (48 h), which induces nitric oxide synthase, resulted in an activation of JNK; this effect was reversed by N-monomethylarginine (NMA).	n-monomethylarginine	112-132	interleukin 1 alpha	Homo sapiens	0-4
11399092-9	2001	IL-1 (48 h), which induces nitric oxide synthase, resulted in an activation of JNK; this effect was reversed by N-monomethylarginine (NMA).	nma	134-137	interleukin 1 alpha	Homo sapiens	0-4
11399092-12	2001	CONCLUSION: We suggest that JNK activation is among the IL-1 elicited responses that injure articular chondrocytes and this activation of JNK is dependent on intracellular oxidant formation (including NO peroxynitrite).	Peroxynitrous Acid	204-217	interleukin 1 alpha	Homo sapiens	56-60
11108714-5	2001	Interleukin-1 (IL-1) appears to mediate dsRNA + IFN-gamma-induced islet damage in a nitric oxide-dependent manner, as the interleukin-1 receptor antagonist protein prevents dsRNA + IFN-gamma-induced iNOS expression, inhibition of insulin secretion, and islet degeneration.	Nitric Oxide	84-96	interleukin 1 alpha	Homo sapiens	15-19
11256945-7	2001	LPS induced endogenous IL-1beta biosynthesis in a time-dependent manner; the administration of exogenous recombinant human interleukin 1 (rhIL-1) resulted in a dose-dependent activation of NF-kappaB.	lps	0-3	interleukin 1 alpha	Homo sapiens	123-144
11396485-0	2001	Is the effect of interleukin-1 on glutathione oxidation in cultured human fibroblasts involved in nuclear factor-kappaB activation?	Glutathione	34-45	interleukin 1 alpha	Homo sapiens	17-30
11396485-3	2001	Here, we investigated the possible role of cellular oxidized/reduced glutathione (GSSG/GSH) balance in IL-1 signaling.	Glutathione	69-80	interleukin 1 alpha	Homo sapiens	103-107
11396485-3	2001	Here, we investigated the possible role of cellular oxidized/reduced glutathione (GSSG/GSH) balance in IL-1 signaling.	Glutathione Disulfide	82-86	interleukin 1 alpha	Homo sapiens	103-107
11396485-5	2001	This method allows the GSSG/GSH balance to be followed during IL-1 stimulation.	Glutathione Disulfide	23-27	interleukin 1 alpha	Homo sapiens	62-66
11396485-5	2001	This method allows the GSSG/GSH balance to be followed during IL-1 stimulation.	Glutathione	28-31	interleukin 1 alpha	Homo sapiens	62-66
11396485-6	2001	Our data show that IL-1 induces rapid and transient oxidation of intracellular glutathione in human fibroblasts.	Glutathione	79-90	interleukin 1 alpha	Homo sapiens	19-23
11281852-5	2001	Furthermore, there is now evidence that the thionamides interfere with thyrocyte expression of such molecules as Class I antigen, interleukin-1, interleukin-6, prostaglandin E2, and heat shock protein.	thionamides	44-55	interleukin 1 alpha	Homo sapiens	113-143
11238627-5	2001	Likewise, SB203580 partially prevented the up-regulation of IL-1alpha, IL-1beta, IL-lRa, and TNF-alpha mRNA upon stimulation with LPS and TNF-alpha, as well as the release of bioactive TNF-alpha induced by LPS.	SB 203580	10-18	interleukin 1 alpha	Homo sapiens	60-69
11321363-4	2001	Whereas IL-1alpha and TNFalpha significantly increased the levels of IL-8, C5a decreased the IL-8 production after 48 h. In addition, the ability of IL-1alpha, TNFalpha, C5a, fMLP and IL-8 to induce cell proliferation was compared by means of a 3H-thymidine incorporation assay.	Tritium	245-247	interleukin 1 alpha	Homo sapiens	149-158
11321363-4	2001	Whereas IL-1alpha and TNFalpha significantly increased the levels of IL-8, C5a decreased the IL-8 production after 48 h. In addition, the ability of IL-1alpha, TNFalpha, C5a, fMLP and IL-8 to induce cell proliferation was compared by means of a 3H-thymidine incorporation assay.	Thymidine	248-257	interleukin 1 alpha	Homo sapiens	149-158
11315998-9	2001	Moreover, SB203580, a specific inhibitor of p38 mitogen-activated protein kinase (MAPK), and PD-98059, a specific inhibitor of MAPK kinase (MEKK), also reduced IL-1alpha and RhoA expression in Ap cells.	SB 203580	10-18	interleukin 1 alpha	Homo sapiens	160-169
11315998-9	2001	Moreover, SB203580, a specific inhibitor of p38 mitogen-activated protein kinase (MAPK), and PD-98059, a specific inhibitor of MAPK kinase (MEKK), also reduced IL-1alpha and RhoA expression in Ap cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	93-101	interleukin 1 alpha	Homo sapiens	160-169
11327259-6	2001	In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA.	Doxycycline	41-52	interleukin 1 alpha	Homo sapiens	159-177
11327259-6	2001	In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA.	Doxycycline	41-52	interleukin 1 alpha	Homo sapiens	179-188
11230753-4	2001	Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha).	Indomethacin	60-72	interleukin 1 alpha	Homo sapiens	192-210
11263772-4	2001	The effect of recombinant OPN (or anti-OPN antiserum) on chondrocyte function was examined by analyzing the spontaneous or interleukin-1 (IL-1)-induced release of nitric oxide (NO) and prostaglandin E2 (PGE2) from human OA-affected cartilage under ex vivo conditions.	Nitric Oxide	163-175	interleukin 1 alpha	Homo sapiens	123-142
11263774-1	2001	OBJECTIVE: To determine the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists on interleukin-1 (IL-1) induction of nitric oxide (NO) and matrix metalloproteinase 13 (MMP-13) in human chondrocytes.	Nitric Oxide	146-158	interleukin 1 alpha	Homo sapiens	112-131
11250126-3	2001	In this study, of the cytokines that are found at increased levels in AD brain (interleukin (IL)-1alpha, IL-1beta, IL-6 and tumour necrosis factor (TNF)alpha), IL-1beta was found to induce COX-2 immunoreactivity and prostaglandin (PG) E2 secretion by human neuroblastoma cell line SK-N-SH.	Prostaglandins	216-231	interleukin 1 alpha	Homo sapiens	80-103
11250126-3	2001	In this study, of the cytokines that are found at increased levels in AD brain (interleukin (IL)-1alpha, IL-1beta, IL-6 and tumour necrosis factor (TNF)alpha), IL-1beta was found to induce COX-2 immunoreactivity and prostaglandin (PG) E2 secretion by human neuroblastoma cell line SK-N-SH.	Prostaglandins	216-231	interleukin 1 alpha	Homo sapiens	160-168
11250126-3	2001	In this study, of the cytokines that are found at increased levels in AD brain (interleukin (IL)-1alpha, IL-1beta, IL-6 and tumour necrosis factor (TNF)alpha), IL-1beta was found to induce COX-2 immunoreactivity and prostaglandin (PG) E2 secretion by human neuroblastoma cell line SK-N-SH.	Dinoprostone	231-237	interleukin 1 alpha	Homo sapiens	80-103
11250126-3	2001	In this study, of the cytokines that are found at increased levels in AD brain (interleukin (IL)-1alpha, IL-1beta, IL-6 and tumour necrosis factor (TNF)alpha), IL-1beta was found to induce COX-2 immunoreactivity and prostaglandin (PG) E2 secretion by human neuroblastoma cell line SK-N-SH.	Dinoprostone	231-237	interleukin 1 alpha	Homo sapiens	160-168
11250126-5	2001	In addition, DEX reduced the IL-1beta induced COX-2 immunoreactivity in the same concentration as wherein it inhibited PGE2 secretion.	Dexamethasone	13-16	interleukin 1 alpha	Homo sapiens	29-37
11250126-5	2001	In addition, DEX reduced the IL-1beta induced COX-2 immunoreactivity in the same concentration as wherein it inhibited PGE2 secretion.	Dinoprostone	119-123	interleukin 1 alpha	Homo sapiens	29-37
11250126-6	2001	Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.	palmitoyl trifluormethyl ketone	0-31	interleukin 1 alpha	Homo sapiens	169-177
11250126-6	2001	Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.	Dinoprostone	186-190	interleukin 1 alpha	Homo sapiens	169-177
11250126-7	2001	This suggests that the IL-1beta induced PGE2 secretion may depend on the availability of arachidonic acid.	Dinoprostone	40-44	interleukin 1 alpha	Homo sapiens	23-31
11250126-7	2001	This suggests that the IL-1beta induced PGE2 secretion may depend on the availability of arachidonic acid.	Arachidonic Acid	89-105	interleukin 1 alpha	Homo sapiens	23-31
11080497-8	2001	Co-transfection with Ras(Asn-17) gave a dose-dependent inhibition of TRAF6-induced responses in the presence and absence of IL-1, but had no effect on MyD88 mediated activity.	asn-17	25-31	interleukin 1 alpha	Homo sapiens	124-128
11230753-4	2001	Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha).	Indomethacin	60-72	interleukin 1 alpha	Homo sapiens	212-221
11230753-4	2001	Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha).	Ibuprofen	76-85	interleukin 1 alpha	Homo sapiens	192-210
11230753-4	2001	Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha).	Ibuprofen	76-85	interleukin 1 alpha	Homo sapiens	212-221
11367542-3	2001	We used two specific inhibitors, SB203580 which selectively inhibits p38 MAP kinase and LY294002 which inhibits PI3-kinase, respectively, to explore the involvement of these kinases in the IL-1-induced NF-kappa B activation, using a human glioblastoma cell line, T98G.	SB 203580	33-41	interleukin 1 alpha	Homo sapiens	189-193
11367542-6	2001	In this context, pretreatment of LY294002, but not SB203580, inhibited IL-1-induced NF-kappa B activation significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	interleukin 1 alpha	Homo sapiens	71-75
11367542-7	2001	While IL-1 induced-AP-1 activation was moderate, both LY294002 and SB203580 suppressed IL-1-induced AP-1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interleukin 1 alpha	Homo sapiens	87-91
11367542-7	2001	While IL-1 induced-AP-1 activation was moderate, both LY294002 and SB203580 suppressed IL-1-induced AP-1 activation.	SB 203580	67-75	interleukin 1 alpha	Homo sapiens	87-91
11367542-9	2001	Namely, LY294002 inhibited TRAF6-mediated IL-1-induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6-induced AP-1 activation but not NF-kappa B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	interleukin 1 alpha	Homo sapiens	42-46
11487149-0	2001	Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1alpha and tumor necrosis factor-alpha through a prostaglandin-dependent pathway.	Prostaglandins	187-200	interleukin 1 alpha	Homo sapiens	126-144
11487149-6	2001	Concomitant addition of IL-1alpha and PGE2 or TNF-alpha and PGE2 suppressed MMP-1 mRNA production, compared with the groups treated with IL-1alpha or TNF-alpha alone.	Dinoprostone	60-64	interleukin 1 alpha	Homo sapiens	137-146
11594168-8	2001	The aims of this study were to determine the IL1 levels in vivo and in the supernatants of cultures of peripheral blood mononuclear cells (PBMC) stimulated or not with LPS in children with FC and in children with fever without FC and to evaluate the influence of ADH and diazepam (DZ) on IL1 production.	Diazepam	271-279	interleukin 1 alpha	Homo sapiens	45-48
11487149-7	2001	In contrast, PGE2 enhanced the upregulatory effects of TIMP-1 mRNA by IL-1alpha or TNF-alpha.	Dinoprostone	13-17	interleukin 1 alpha	Homo sapiens	70-79
11487149-10	2001	The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.	Prostaglandins	183-196	interleukin 1 alpha	Homo sapiens	31-40
11288755-10	2001	Northern blotting analysis showed increased interleukin-1alpha (IL-1alpha) mRNA after silica treatment.	Silicon Dioxide	86-92	interleukin 1 alpha	Homo sapiens	44-62
11288755-10	2001	Northern blotting analysis showed increased interleukin-1alpha (IL-1alpha) mRNA after silica treatment.	Silicon Dioxide	86-92	interleukin 1 alpha	Homo sapiens	64-73
11288755-13	2001	However, contradicting our hypothesis, silica antagonized TGFbeta activities through a TGFbeta downregulation and an IL-1alpha upregulation.	Silicon Dioxide	39-45	interleukin 1 alpha	Homo sapiens	117-126
11288755-14	2001	The complex pattern of TGFbeta and IL-1alpha regulation in pulmonary fibroblasts is imbalanced by silica exposure and might play a key role in silica-mediated pulmonary fibrosis.	Silicon Dioxide	98-104	interleukin 1 alpha	Homo sapiens	35-44
11288755-14	2001	The complex pattern of TGFbeta and IL-1alpha regulation in pulmonary fibroblasts is imbalanced by silica exposure and might play a key role in silica-mediated pulmonary fibrosis.	Silicon Dioxide	143-149	interleukin 1 alpha	Homo sapiens	35-44
24387017-6	2001	In addition, mizoribine inhibited the enhanced production of IL-6 by the IL-1alpha and/or tumor necrosis factor alpha-stimulated RSC.	mizoribine	13-23	interleukin 1 alpha	Homo sapiens	73-82
11228400-0	2001	Interleukin-4 reversed the Interleukin-1-inhibited proteoglycan synthesis through the inhibition of NO release: a possible involvement of intracellular calcium ion.	Calcium	152-159	interleukin 1 alpha	Homo sapiens	27-40
11228400-1	2001	Interleukin-1 (IL-1) causes cartilage degradation through nitric oxide (NO) synthesis.	Nitric Oxide	58-70	interleukin 1 alpha	Homo sapiens	0-13
11228400-1	2001	Interleukin-1 (IL-1) causes cartilage degradation through nitric oxide (NO) synthesis.	Nitric Oxide	58-70	interleukin 1 alpha	Homo sapiens	15-19
11594168-8	2001	The aims of this study were to determine the IL1 levels in vivo and in the supernatants of cultures of peripheral blood mononuclear cells (PBMC) stimulated or not with LPS in children with FC and in children with fever without FC and to evaluate the influence of ADH and diazepam (DZ) on IL1 production.	Diazepam	281-283	interleukin 1 alpha	Homo sapiens	45-48
11156550-0	2001	Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.	esculetin	0-9	interleukin 1 alpha	Homo sapiens	51-69
11050099-0	2001	Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties.	Calcium	101-108	interleukin 1 alpha	Homo sapiens	31-40
11050099-0	2001	Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties.	Carbohydrates	121-133	interleukin 1 alpha	Homo sapiens	31-40
11160316-0	2001	Cloning of human preprotachykinin-I promoter and the role of cyclic adenosine 5"-monophosphate response elements in its expression by IL-1 and stem cell factor.	cyclic adenosine 5"-monophosphate	61-94	interleukin 1 alpha	Homo sapiens	134-138
11167182-11	2001	CONCLUSIONS: Results suggest that IL-1alpha induce the PGHS-2 mRNA and stimulate the production of PGE2 by a mechanism that involves the sphingomyelin-ceramide system.	Sphingomyelins	137-150	interleukin 1 alpha	Homo sapiens	34-43
11160202-5	2001	On the other hand, ATP markedly and dose-dependently inhibited LPS- and soluble CD40 ligand-dependent production of IL-1alpha, IL-1beta, TNF-alpha, IL-6, and IL-12, whereas IL-1 receptor antagonist and IL-10 production was not affected.	Adenosine Triphosphate	19-22	interleukin 1 alpha	Homo sapiens	116-125
11167182-11	2001	CONCLUSIONS: Results suggest that IL-1alpha induce the PGHS-2 mRNA and stimulate the production of PGE2 by a mechanism that involves the sphingomyelin-ceramide system.	Ceramides	151-159	interleukin 1 alpha	Homo sapiens	34-43
11167182-0	2001	Effect of ceramide analogs on interleukin-1alpha-induced production of prostaglandin E2 by amnion-derived (WISH) cells.	Ceramides	10-18	interleukin 1 alpha	Homo sapiens	30-48
11574733-11	2001	C3a, C5a, and IL-1 levels during Cuprophan and Hemophan treatments were significantly higher than the levels during modified cellulose treatment at 30 and 60 min and Post (p &lt; 0.01).	cuprammonium cellulose	33-42	interleukin 1 alpha	Homo sapiens	14-18
11167182-0	2001	Effect of ceramide analogs on interleukin-1alpha-induced production of prostaglandin E2 by amnion-derived (WISH) cells.	Dinoprostone	71-87	interleukin 1 alpha	Homo sapiens	30-48
11167182-2	2001	Our objective was to measure the level of PGE2 induced by interleukin (IL)-1alpha following treatment with ceramide analogs in amnion-derived cells.	Dinoprostone	42-46	interleukin 1 alpha	Homo sapiens	58-81
11167182-2	2001	Our objective was to measure the level of PGE2 induced by interleukin (IL)-1alpha following treatment with ceramide analogs in amnion-derived cells.	Ceramides	107-115	interleukin 1 alpha	Homo sapiens	58-81
11167182-6	2001	RESULTS: Following stimulation with IL-1alpha, the production of PGE2 could not be detected until incubation had continued for 2 h, but this production appeared to continue after 4 h of incubation.	Dinoprostone	65-69	interleukin 1 alpha	Homo sapiens	36-45
11167182-7	2001	The production of PGE2 was significantly increased by IL-1alpha, and was suppressed by IL-1 ra, in a dose-dependent manner.	Dinoprostone	18-22	interleukin 1 alpha	Homo sapiens	54-63
11167182-8	2001	PGE2 production was significantly increased by IL-1alpha and C2-ceramide as compared with IL-1alpha alone.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	47-56
11167182-8	2001	PGE2 production was significantly increased by IL-1alpha and C2-ceramide as compared with IL-1alpha alone.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	90-99
11167182-11	2001	CONCLUSIONS: Results suggest that IL-1alpha induce the PGHS-2 mRNA and stimulate the production of PGE2 by a mechanism that involves the sphingomyelin-ceramide system.	Dinoprostone	99-103	interleukin 1 alpha	Homo sapiens	34-43
11574733-11	2001	C3a, C5a, and IL-1 levels during Cuprophan and Hemophan treatments were significantly higher than the levels during modified cellulose treatment at 30 and 60 min and Post (p &lt; 0.01).	Hemophan	47-55	interleukin 1 alpha	Homo sapiens	14-18
11154858-4	2001	Colchicine also inhibited VCAM-1 induction on both TNFalpha- and IL-1alpha-stimulated human umbilical vein endothelial cells (HUVEC).	Colchicine	0-10	interleukin 1 alpha	Homo sapiens	65-74
11340307-0	2001	1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells.	Calcitriol	0-24	interleukin 1 alpha	Homo sapiens	50-59
11340307-9	2001	After 72 h, 1,25-D3 enhanced the IL-1alpha-stimulated MCP-1 secretion.	1,25-d3	12-19	interleukin 1 alpha	Homo sapiens	33-42
11367519-6	2001	Similarly, griseofulvin inhibited the induction of VCAM-1 expression on both TNF alpha- and IL-1 alpha-stimulated human umbilical vein endothelial cells (HUVEC).	Griseofulvin	11-23	interleukin 1 alpha	Homo sapiens	92-102
11581570-10	2001	According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18.	Lipid A	83-90	interleukin 1 alpha	Homo sapiens	409-413
11455120-12	2001	Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity.	Prostaglandins E	129-132	interleukin 1 alpha	Homo sapiens	110-114
11137138-7	2001	The addition of dexamethasone (required to reduce pain with the highest doses) inhibited IL-1alpha and enhanced the induction of IL-1ra by VRCTC-310-Onco.	Dexamethasone	16-29	interleukin 1 alpha	Homo sapiens	89-98
11201166-4	2001	IL-1 up-regulates IL-1RI through prostaglandin E2 (PGE2) production on human fibroblasts.	Dinoprostone	33-49	interleukin 1 alpha	Homo sapiens	0-4
11243562-2	2001	We investigated the effects of rhein, an active metabolite of diacerein, on the degradation of recombinant human interleukin-1alpha (rhIL-1alpha)-induced proteoglycan and matrix metalloproteinases (MMPs) release from rabbit articular chondrocytes.	diacerein	62-71	interleukin 1 alpha	Homo sapiens	113-131
11169201-7	2001	IL-1, known to upregulate extrahepatic A-SAA gene expression in other cell systems only slightly, if at all, upregulated Dex-induced A-SAA expression by HASMC.	Dexamethasone	121-124	interleukin 1 alpha	Homo sapiens	0-4
11169201-7	2001	IL-1, known to upregulate extrahepatic A-SAA gene expression in other cell systems only slightly, if at all, upregulated Dex-induced A-SAA expression by HASMC.	hasmc	153-158	interleukin 1 alpha	Homo sapiens	0-4
11752890-2	2001	IL-1 and LPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man.	Norepinephrine	70-84	interleukin 1 alpha	Homo sapiens	0-4
11752890-2	2001	IL-1 and LPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man.	Serotonin	89-98	interleukin 1 alpha	Homo sapiens	0-4
11201166-4	2001	IL-1 up-regulates IL-1RI through prostaglandin E2 (PGE2) production on human fibroblasts.	Dinoprostone	33-49	interleukin 1 alpha	Homo sapiens	18-22
11201166-4	2001	IL-1 up-regulates IL-1RI through prostaglandin E2 (PGE2) production on human fibroblasts.	Dinoprostone	51-55	interleukin 1 alpha	Homo sapiens	0-4
11201166-4	2001	IL-1 up-regulates IL-1RI through prostaglandin E2 (PGE2) production on human fibroblasts.	Dinoprostone	51-55	interleukin 1 alpha	Homo sapiens	18-22
11007619-4	2000	Exposure to titanium-aluminum-vanadium particles significantly changed the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1), whereas there was no significant effect on the release of prostaglandin E(2) (PGE(2)).	titanium-aluminum-vanadium	12-38	interleukin 1 alpha	Homo sapiens	168-172
11120850-2	2000	We report in this study that vitamin C inhibits the activation of NF-kappaB by multiple stimuli, including IL-1 and TNF in the endothelial cell line ECV304 and in primary HUVECs.	Ascorbic Acid	29-38	interleukin 1 alpha	Homo sapiens	107-111
11120850-7	2000	Vitamin C was shown to block IL-1- and TNF-mediated degradation and phosphorylation of I-kappaBalpha (inhibitory protein that dissociates from NF-kappaB), due to inhibition of I-kappaB kinase (IKK) activation.	Ascorbic Acid	0-9	interleukin 1 alpha	Homo sapiens	29-33
11007619-10	2000	Pentoxifylline potentiated IL-6 and IL-1 production in monocytes exposed to titanium particles and had a biphasic effect on the PGE(2) production.	Pentoxifylline	0-14	interleukin 1 alpha	Homo sapiens	36-40
11007619-13	2000	The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes.	Ciprofloxacin	26-39	interleukin 1 alpha	Homo sapiens	160-164
11007619-5	2000	When monocytes were cultured with particles, the titanium alloy particles induced significantly more release of TNF-alpha and less IL-1 secretion.	Titanium	49-63	interleukin 1 alpha	Homo sapiens	131-135
11007619-13	2000	The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes.	Pentoxifylline	41-55	interleukin 1 alpha	Homo sapiens	160-164
11007619-6	2000	Ciprofloxacin inhibited production of TNF-alpha, IL-6, IL-1, and PGE(2) in human monocytes exposed to titanium particles.	Ciprofloxacin	0-13	interleukin 1 alpha	Homo sapiens	55-59
11007619-13	2000	The pharmacologic agents (ciprofloxacin, pentoxifylline, and indomethacin) that can modulate the release of bone resorbing mediators such as PGE(2), TNF-alpha, IL-1, and IL-6 release from human monocytes.	Indomethacin	61-73	interleukin 1 alpha	Homo sapiens	160-164
11007619-6	2000	Ciprofloxacin inhibited production of TNF-alpha, IL-6, IL-1, and PGE(2) in human monocytes exposed to titanium particles.	Titanium	102-110	interleukin 1 alpha	Homo sapiens	55-59
11073827-0	2000	Defective interleukin-1 receptor antagonist production is associated with resistance of acute liver graft rejection to steroid therapy.	Steroids	119-126	interleukin 1 alpha	Homo sapiens	10-23
11121511-12	2000	On the other hand, in certain local responses, and under certain conditions, catecholamines may actually boost regional immune responses, through induction of IL-1, tumor necrosis factor-alpha, and primarily IL-8 production.	Catecholamines	77-91	interleukin 1 alpha	Homo sapiens	159-192
11603298-2	2000	FI0-c, and its sulfated derivative, FI0-c-S, on production of human proinflammatory cytokines, interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha).	Carbon	4-5	interleukin 1 alpha	Homo sapiens	95-114
11603298-2	2000	FI0-c, and its sulfated derivative, FI0-c-S, on production of human proinflammatory cytokines, interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha).	Carbon	4-5	interleukin 1 alpha	Homo sapiens	116-126
11603298-6	2000	On the other hand, FI0-c and FI0-c-S inhibited the IL-1 alpha production by THP-1 cells with these stimulants.	fi0-c	19-24	interleukin 1 alpha	Homo sapiens	51-61
11603298-6	2000	On the other hand, FI0-c and FI0-c-S inhibited the IL-1 alpha production by THP-1 cells with these stimulants.	fi0-c-s	29-36	interleukin 1 alpha	Homo sapiens	51-61
11603298-8	2000	Human peripheral blood mononuclear cells (PBMC) responded to FI0-c and FI0-c-S in IL-1 alpha and TNF alpha production in a fashion similar to THP-1 cell responses.	fi0-c-s	71-78	interleukin 1 alpha	Homo sapiens	82-92
11603298-9	2000	FI0-c 4 mg/L downregulated high-dose LPS- and PMA-induced IL-1 alpha or TNF alpha mRNA and their protein production by THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 alpha	Homo sapiens	58-68
11198376-6	2000	After treatment with triclabendazole IL-1, IL-4 and IgE levels moved towards the control indicating obvious improvement in the immunological responses of the patients.	Triclabendazole	21-36	interleukin 1 alpha	Homo sapiens	37-41
11073827-6	2000	IL-1 production and its inhibition by steroids were similar in steroid-responsive and steroid-resistant rejection.	Steroids	38-45	interleukin 1 alpha	Homo sapiens	0-4
11073827-6	2000	IL-1 production and its inhibition by steroids were similar in steroid-responsive and steroid-resistant rejection.	Steroids	63-70	interleukin 1 alpha	Homo sapiens	0-4
11073827-2	2000	As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra.	Steroids	50-57	interleukin 1 alpha	Homo sapiens	3-16
11073827-2	2000	As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra.	Steroids	50-57	interleukin 1 alpha	Homo sapiens	18-22
11078862-0	2000	Doxycycline inhibition of interleukin-1 in the corneal epithelium	Doxycycline	0-11	interleukin 1 alpha	Homo sapiens	26-39
11073827-2	2000	As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra.	Steroids	149-157	interleukin 1 alpha	Homo sapiens	130-134
11073827-6	2000	IL-1 production and its inhibition by steroids were similar in steroid-responsive and steroid-resistant rejection.	Steroids	38-46	interleukin 1 alpha	Homo sapiens	0-4
11046056-4	2000	IL-1, TNF-alpha, and LPS blocked the activation of Stat DNA binding and tyrosine phosphorylation by IL-6 and IL-10, but not by IFN-gamma, in primary macrophages.	Tyrosine	72-80	interleukin 1 alpha	Homo sapiens	0-4
11197525-2	2000	Stimulation of fibroblasts with TNF-alpha or IL-1alpha transiently increases the production of reactive oxygen species (ROS) in human fibroblasts.	Reactive Oxygen Species	95-118	interleukin 1 alpha	Homo sapiens	45-54
11197525-2	2000	Stimulation of fibroblasts with TNF-alpha or IL-1alpha transiently increases the production of reactive oxygen species (ROS) in human fibroblasts.	Reactive Oxygen Species	120-123	interleukin 1 alpha	Homo sapiens	45-54
11197525-3	2000	Here we propose that repeated stimulation of WI-38 fibroblasts with TNF-alpha or IL-1alpha can generate enough ROS to accelerate the transition in the fibroblast morphotypes and increase the proportion of cells positive for senescence associated beta-galactosidase activity.	Reactive Oxygen Species	111-114	interleukin 1 alpha	Homo sapiens	81-90
11197525-4	2000	The involvement of ROS is suggested by experiments where the stimulation of fibroblasts with TNF-alpha or IL-1alpha are performed in the presence of N-acetylcysteine which increases the intracellular antioxidant potential.	Reactive Oxygen Species	19-22	interleukin 1 alpha	Homo sapiens	106-115
11197525-4	2000	The involvement of ROS is suggested by experiments where the stimulation of fibroblasts with TNF-alpha or IL-1alpha are performed in the presence of N-acetylcysteine which increases the intracellular antioxidant potential.	Acetylcysteine	149-165	interleukin 1 alpha	Homo sapiens	106-115
11197525-5	2000	It is proposed that the decrease in the proportions of morphotypes I and II, and the increase in the proportions of morphotypes III to VI observed after successive stimulation with TNF-alpha or IL1-alpha is attributed to an increased ROS production occurring during the stimulation.	Reactive Oxygen Species	234-237	interleukin 1 alpha	Homo sapiens	194-203
11108661-9	2000	Induction of TAM67 inhibited or reduced the expression of collagenase I, stromelysin I (AP-1 responsive), and interleukins 1 and 6 (NFkappaB responsive).	tam67	13-18	interleukin 1 alpha	Homo sapiens	110-130
10926834-4	2000	Treatment of the cells with forskolin or dibutyryl-cAMP attenuated the expression of M-CSF induced by IL-1alpha or LPS, but not by PMA.	Colforsin	28-37	interleukin 1 alpha	Homo sapiens	102-111
10882746-6	2000	Immunolocalization experiments showed that DIPEN(341) and ITEGE(373) epitopes were increased by treatment with IL-1alpha and retinoate.	dipen	43-48	interleukin 1 alpha	Homo sapiens	111-120
11121687-7	2000	Indomethacin reduced the production of LPS-induced IL-6, IL-1 beta and IL-10 (p<0.05) at the highest indomethacin concentration tested.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	57-66
10952930-6	2000	Myometrial cells were treated with IL-1 for 24 h. Oxytocin-stimulated inositol trisphosphate (IP(3)) production was measured in tritiated myoinositol-loaded myometrial cells.	inositol 1,2,3-trisphosphate	70-92	interleukin 1 alpha	Homo sapiens	35-39
10952930-6	2000	Myometrial cells were treated with IL-1 for 24 h. Oxytocin-stimulated inositol trisphosphate (IP(3)) production was measured in tritiated myoinositol-loaded myometrial cells.	Inositol 1,4,5-Trisphosphate	94-99	interleukin 1 alpha	Homo sapiens	35-39
10952930-10	2000	Prolonged exposure of myometrial cells to IL-1 resulted in a significant reduction in oxytocin-mediated signaling as measured by IP(3) production and AA release, as well as a decrease in intracellular calcium.	Inositol 1,4,5-Trisphosphate	129-134	interleukin 1 alpha	Homo sapiens	42-46
10952930-10	2000	Prolonged exposure of myometrial cells to IL-1 resulted in a significant reduction in oxytocin-mediated signaling as measured by IP(3) production and AA release, as well as a decrease in intracellular calcium.	Calcium	201-208	interleukin 1 alpha	Homo sapiens	42-46
10952930-11	2000	Prolonged exposure of myometrial cells to IL-1, however, resulted in enhanced PG release.	Prostaglandins	78-80	interleukin 1 alpha	Homo sapiens	42-46
10940814-6	2000	Dose-dependent increases in the levels of IL-1alpha and HETEs were observed in the underlying medium of the skin systems exposed to two skin irritants, glutaraldehyde and SLS.	Glutaral	152-166	interleukin 1 alpha	Homo sapiens	42-51
11069728-4	2000	However, there was a potent, dose-dependent inhibition of nitric oxide (NO) release from IL-1 alpha-stimulated BAC with an IC(50)of approximately 0.6 microM, with similar effects observed in primary chondrocytes.	Nitric Oxide	58-70	interleukin 1 alpha	Homo sapiens	89-99
11039768-6	2000	Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor.	Nitric Oxide	45-57	interleukin 1 alpha	Homo sapiens	6-19
11039768-6	2000	Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor.	Dinoprostone	59-75	interleukin 1 alpha	Homo sapiens	6-19
11039768-8	2000	Similarly, 1 ng/mL human interleukin-1 induced (or spontaneously produced) nitric oxide and prostaglandin E2 production in human osteoarthritis-affected cartilage could be inhibited by 50% or greater with 100 pg/mL Type II interleukin-1 receptor in ex vivo conditions.	Nitric Oxide	75-87	interleukin 1 alpha	Homo sapiens	25-38
11039768-8	2000	Similarly, 1 ng/mL human interleukin-1 induced (or spontaneously produced) nitric oxide and prostaglandin E2 production in human osteoarthritis-affected cartilage could be inhibited by 50% or greater with 100 pg/mL Type II interleukin-1 receptor in ex vivo conditions.	Dinoprostone	92-108	interleukin 1 alpha	Homo sapiens	25-38
11039768-8	2000	Similarly, 1 ng/mL human interleukin-1 induced (or spontaneously produced) nitric oxide and prostaglandin E2 production in human osteoarthritis-affected cartilage could be inhibited by 50% or greater with 100 pg/mL Type II interleukin-1 receptor in ex vivo conditions.	Dinoprostone	92-108	interleukin 1 alpha	Homo sapiens	223-236
11110032-1	2000	Interleukin-1 (IL-1) is known to trigger induction of inducible nitric oxide synthase (iNOS) to persistently mass produce nitric oxide (NO) to induce various diseases such as cancer, inflammation, Alzheimer"s disease and eye diseases, including uveitis, retinopathy, age-related macular degeneration, glaucoma and myopia.	Nitric Oxide	64-76	interleukin 1 alpha	Homo sapiens	0-13
11110032-1	2000	Interleukin-1 (IL-1) is known to trigger induction of inducible nitric oxide synthase (iNOS) to persistently mass produce nitric oxide (NO) to induce various diseases such as cancer, inflammation, Alzheimer"s disease and eye diseases, including uveitis, retinopathy, age-related macular degeneration, glaucoma and myopia.	Nitric Oxide	64-76	interleukin 1 alpha	Homo sapiens	15-19
11007863-0	2000	Changing relationships between serum IL-1, IL-6, and TNF-alpha and dynamic tests of parathyroid gland function in haemodialysis patients with severe hyperparathyroidism in response to calcitriol therapy.	Calcitriol	184-194	interleukin 1 alpha	Homo sapiens	37-41
11984716-2	2000	The aim of this study was to clarify the relationship between growth activity evaluated by DNA analysis and the concentration of tumor-derived IL-1alpha in gastric cancers in clinical cases.METHODS: We measured the concentration of IL-1alpha in homogenized tumor samples obtained from 49 patients with gastric cancer, using an enzyme-linked immunosorbent assay, and we analyzed the cellular DNA content of paraffin-embedded tumor sections using flow cytometry.RESULTS: Both the IL-1alpha concentration and the percentage of S-phase fraction were significantly correlated with liver metastasis, histologic type, pattern of tumor infiltration, quantity of stroma, and venous invasion.	Paraffin	406-414	interleukin 1 alpha	Homo sapiens	143-152
10946302-5	2000	Unexpectedly, pretreatment with simvastatin potentiated the induction of all three endothelial CAMs by IL-1 and TNF, but not LPS or PMA, as detected by flow cytometry.	Simvastatin	32-43	interleukin 1 alpha	Homo sapiens	103-115
10926834-4	2000	Treatment of the cells with forskolin or dibutyryl-cAMP attenuated the expression of M-CSF induced by IL-1alpha or LPS, but not by PMA.	Bucladesine	41-55	interleukin 1 alpha	Homo sapiens	102-111
10934644-7	2000	Osteoclast formation also was stimulated (in the presence of Dex) by prostaglandin E2 (PGE2), interleukin-11 (IL-11), IL-1, tumor necrosis factor-alpha (TNF-alpha), and parathyroid hormone-related protein (PTHrP), factors which also stimulate osteoclast formation supported by osteoblasts.	Dexamethasone	61-64	interleukin 1 alpha	Homo sapiens	118-151
10922312-2	2000	Several inflammatory cytokines involved in malnutrition, including interleukin-1, interleukin-6, and tumor necrosis factor-alpha, are modulated by 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)], of which synthesis is impaired in end-stage renal disease.	1,25-dihydroxyvitamin D	147-170	interleukin 1 alpha	Homo sapiens	67-80
10928970-10	2000	These results, taken together with our previous findings (i) suggest that IL-1 is involved in the aminoBP-induced inflammatory reactions and (ii) lead us to think that under some conditions, inflammatory reactions induced by gram-negative bacteria might be augmented in patients treated with an aminoBP.	aminobp	98-105	interleukin 1 alpha	Homo sapiens	74-78
10928970-10	2000	These results, taken together with our previous findings (i) suggest that IL-1 is involved in the aminoBP-induced inflammatory reactions and (ii) lead us to think that under some conditions, inflammatory reactions induced by gram-negative bacteria might be augmented in patients treated with an aminoBP.	aminobp	295-302	interleukin 1 alpha	Homo sapiens	74-78
10946830-3	2000	PTAE (0.01-1 microg/ml) dose-dependently inhibited the EtOH-induced interleukin-1alpha (IL-1alpha) secretion.	Ethanol	55-59	interleukin 1 alpha	Homo sapiens	68-86
10946830-3	2000	PTAE (0.01-1 microg/ml) dose-dependently inhibited the EtOH-induced interleukin-1alpha (IL-1alpha) secretion.	Ethanol	55-59	interleukin 1 alpha	Homo sapiens	88-97
10946830-4	2000	PTAE (0.01-1 microg/ml) also inhibited the EtOH- and IL-1alpha-induced cytotoxicity.	ptae	0-4	interleukin 1 alpha	Homo sapiens	53-62
10946830-5	2000	Furthermore, we found that PTAE inhibited the IL-1alpha-induced apoptosis of Hep G2 cells.	ptae	27-31	interleukin 1 alpha	Homo sapiens	46-55
10937565-0	2000	Doxycycline inhibition of interleukin-1 in the corneal epithelium.	Doxycycline	0-11	interleukin 1 alpha	Homo sapiens	26-39
10947068-6	2000	Furthermore, inhibition of TNF-alpha/beta and IL-1alpha/beta, together with CD40 ligand, failed to inhibit EC activation by resting T cells and only inhibited the response to PMA- and ionomycin-activated T cells by 40 +/- 18%.	Tetradecanoylphorbol Acetate	175-178	interleukin 1 alpha	Homo sapiens	46-55
10947068-6	2000	Furthermore, inhibition of TNF-alpha/beta and IL-1alpha/beta, together with CD40 ligand, failed to inhibit EC activation by resting T cells and only inhibited the response to PMA- and ionomycin-activated T cells by 40 +/- 18%.	Ionomycin	184-193	interleukin 1 alpha	Homo sapiens	46-55
11360675-0	2000	Effects of antisense IRAK-2 oligonucleotides on PGI2 release induced by IL-1 and TNF.	Oligonucleotides	28-44	interleukin 1 alpha	Homo sapiens	72-76
10951249-4	2000	3,5-xylenol, chloroxylenol, hexyl-resorcinol, and sodium dodecyl sulfate, but not resorcinol or phenol, induced release of interleukin-1alpha from keratinocytes at cytotoxic concentrations.	3,5-xylenol	0-11	interleukin 1 alpha	Homo sapiens	123-141
10951249-4	2000	3,5-xylenol, chloroxylenol, hexyl-resorcinol, and sodium dodecyl sulfate, but not resorcinol or phenol, induced release of interleukin-1alpha from keratinocytes at cytotoxic concentrations.	chloroxylenol	13-26	interleukin 1 alpha	Homo sapiens	123-141
10951249-4	2000	3,5-xylenol, chloroxylenol, hexyl-resorcinol, and sodium dodecyl sulfate, but not resorcinol or phenol, induced release of interleukin-1alpha from keratinocytes at cytotoxic concentrations.	Hexylresorcinol	28-44	interleukin 1 alpha	Homo sapiens	123-141
10951249-4	2000	3,5-xylenol, chloroxylenol, hexyl-resorcinol, and sodium dodecyl sulfate, but not resorcinol or phenol, induced release of interleukin-1alpha from keratinocytes at cytotoxic concentrations.	Sodium Dodecyl Sulfate	50-72	interleukin 1 alpha	Homo sapiens	123-141
10951249-4	2000	3,5-xylenol, chloroxylenol, hexyl-resorcinol, and sodium dodecyl sulfate, but not resorcinol or phenol, induced release of interleukin-1alpha from keratinocytes at cytotoxic concentrations.	resorcinol	34-44	interleukin 1 alpha	Homo sapiens	123-141
10915563-8	2000	Treatment of coelomocytes (labeled with IL-1alpha) with bivalent water-soluble crosslinkers identified a membrane protein of approximately 70 kDa to which IL-1 is specifically crosslinked.	Water	65-70	interleukin 1 alpha	Homo sapiens	40-49
11055589-2	2000	Interleukin-1 (IL-1), a monocyte/ macrophage product that stimulates synovial fibroblasts to produce matrix metalloproteinases (MMPs), prostaglandins, and other cytokines, also has profound effects on the synthesis of extracellular matrix components such as type I collagen.	Prostaglandins	135-149	interleukin 1 alpha	Homo sapiens	0-13
11055589-2	2000	Interleukin-1 (IL-1), a monocyte/ macrophage product that stimulates synovial fibroblasts to produce matrix metalloproteinases (MMPs), prostaglandins, and other cytokines, also has profound effects on the synthesis of extracellular matrix components such as type I collagen.	Prostaglandins	135-149	interleukin 1 alpha	Homo sapiens	15-19
11055589-3	2000	In previous studies, we have shown that synovial fibroblasts and chondrocytes isolated from human joint tissues are particularly sensitive to prostaglandins, which modulate the effects of IL-1 on collagen gene expression in an autocrine manner.	Prostaglandins	142-156	interleukin 1 alpha	Homo sapiens	188-192
11055589-7	2000	RESULTS: IL-1 increased the synthesis of type I and type III collagens in BALBc/3T3 fibroblasts; greater increases were observed when IL-1-stimulated synthesis of PGE2 was blocked by indomethacin.	Dinoprostone	163-167	interleukin 1 alpha	Homo sapiens	9-13
11055589-7	2000	RESULTS: IL-1 increased the synthesis of type I and type III collagens in BALBc/3T3 fibroblasts; greater increases were observed when IL-1-stimulated synthesis of PGE2 was blocked by indomethacin.	Dinoprostone	163-167	interleukin 1 alpha	Homo sapiens	134-138
11055589-7	2000	RESULTS: IL-1 increased the synthesis of type I and type III collagens in BALBc/3T3 fibroblasts; greater increases were observed when IL-1-stimulated synthesis of PGE2 was blocked by indomethacin.	Indomethacin	183-195	interleukin 1 alpha	Homo sapiens	9-13
11055589-7	2000	RESULTS: IL-1 increased the synthesis of type I and type III collagens in BALBc/3T3 fibroblasts; greater increases were observed when IL-1-stimulated synthesis of PGE2 was blocked by indomethacin.	Indomethacin	183-195	interleukin 1 alpha	Homo sapiens	134-138
11055589-10	2000	CONCLUSIONS: These results show that the inhibition of Col1a1 expression by IL-1 in fibroblasts is mediated by prostaglandins at the transcriptional level and suggest that PGE-responsive factors may interact directly or indirectly with basal regulatory elements in the proximal promoter region of the Col1a1 gene.	Prostaglandins	111-125	interleukin 1 alpha	Homo sapiens	76-80
11055589-10	2000	CONCLUSIONS: These results show that the inhibition of Col1a1 expression by IL-1 in fibroblasts is mediated by prostaglandins at the transcriptional level and suggest that PGE-responsive factors may interact directly or indirectly with basal regulatory elements in the proximal promoter region of the Col1a1 gene.	Prostaglandins E	172-175	interleukin 1 alpha	Homo sapiens	76-80
11360675-0	2000	Effects of antisense IRAK-2 oligonucleotides on PGI2 release induced by IL-1 and TNF.	Epoprostenol	48-52	interleukin 1 alpha	Homo sapiens	72-76
11360675-1	2000	AIM: To explore the effects of antisense interleukin-1 receptor associated kinase-2 oligonucleotide (IRAK-2 ODN) on the prostacyclin (PGI2) synthesis in human umbilical vein endothelial cells (HUVEC) induced by interleukin-1 (IL-1) and tumor necrosis factor (TNF).	Epoprostenol	120-132	interleukin 1 alpha	Homo sapiens	41-54
11360675-1	2000	AIM: To explore the effects of antisense interleukin-1 receptor associated kinase-2 oligonucleotide (IRAK-2 ODN) on the prostacyclin (PGI2) synthesis in human umbilical vein endothelial cells (HUVEC) induced by interleukin-1 (IL-1) and tumor necrosis factor (TNF).	Epoprostenol	134-138	interleukin 1 alpha	Homo sapiens	41-54
11360675-4	2000	RESULTS: Pre-transfection with antisense IRAK-2 ODN could remarkably decrease the levels of PGI2 synthesis induced by IL-1 in a time- and concentration-dependent manner, whereas it could not attenuate the one stimulated by TNF.	Epoprostenol	92-96	interleukin 1 alpha	Homo sapiens	118-122
11360675-6	2000	IRAK-2 plays a key role in the IL-1 signaling events leading to PGI2 release.	Epoprostenol	64-68	interleukin 1 alpha	Homo sapiens	31-35
11039223-7	2000	Ovarian steroids inhibit MMP-1 production by IL-1 alpha-stimulated fibroblasts in vitro.	Steroids	8-16	interleukin 1 alpha	Homo sapiens	45-55
10893205-2	2000	To address this concern, we investigated the role of the neutrophil agonist platelet-activating factor [1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF)] in the development of the acute neutrophil-dependent lung leak that is induced by giving IL-1 intratracheally to rats.	Platelet Activating Factor	104-150	interleukin 1 alpha	Homo sapiens	247-251
10893205-5	2000	Additionally, neutrophils recovered from the lung lavage fluid of rats given IL-1 intratracheally reduced more nitro blue tetrazolium (NBT) in vitro than neutrophils recovered from control rats or rats that had been given WEB-2086 and then IL-1.	Nitroblue Tetrazolium	111-133	interleukin 1 alpha	Homo sapiens	77-81
10893205-5	2000	Additionally, neutrophils recovered from the lung lavage fluid of rats given IL-1 intratracheally reduced more nitro blue tetrazolium (NBT) in vitro than neutrophils recovered from control rats or rats that had been given WEB-2086 and then IL-1.	Nitroblue Tetrazolium	135-138	interleukin 1 alpha	Homo sapiens	77-81
10893205-6	2000	Histological examination indicated that the endothelial cell-neutrophil interfaces of cerium chloride-stained lung sections of rats given IL-1 contained increased cerium perhydroxide (the reaction product of cerium chloride with hydrogen peroxide) compared with lungs of control rats or rats treated with WEB-2086 and then given IL-1 intratracheally.	cerous chloride	86-101	interleukin 1 alpha	Homo sapiens	138-142
10893205-6	2000	Histological examination indicated that the endothelial cell-neutrophil interfaces of cerium chloride-stained lung sections of rats given IL-1 contained increased cerium perhydroxide (the reaction product of cerium chloride with hydrogen peroxide) compared with lungs of control rats or rats treated with WEB-2086 and then given IL-1 intratracheally.	cerous chloride	86-101	interleukin 1 alpha	Homo sapiens	329-333
10893205-6	2000	Histological examination indicated that the endothelial cell-neutrophil interfaces of cerium chloride-stained lung sections of rats given IL-1 contained increased cerium perhydroxide (the reaction product of cerium chloride with hydrogen peroxide) compared with lungs of control rats or rats treated with WEB-2086 and then given IL-1 intratracheally.	cerium hydroxide	163-182	interleukin 1 alpha	Homo sapiens	138-142
10893205-6	2000	Histological examination indicated that the endothelial cell-neutrophil interfaces of cerium chloride-stained lung sections of rats given IL-1 contained increased cerium perhydroxide (the reaction product of cerium chloride with hydrogen peroxide) compared with lungs of control rats or rats treated with WEB-2086 and then given IL-1 intratracheally.	cerous chloride	208-223	interleukin 1 alpha	Homo sapiens	138-142
10893205-6	2000	Histological examination indicated that the endothelial cell-neutrophil interfaces of cerium chloride-stained lung sections of rats given IL-1 contained increased cerium perhydroxide (the reaction product of cerium chloride with hydrogen peroxide) compared with lungs of control rats or rats treated with WEB-2086 and then given IL-1 intratracheally.	Hydrogen Peroxide	229-246	interleukin 1 alpha	Homo sapiens	138-142
11039223-9	2000	However, IL-1 alpha-stimulated MMP-1 production in the human endometrium is effectively blocked by ovarian steroids.	Steroids	107-115	interleukin 1 alpha	Homo sapiens	9-19
11031321-9	2000	We conclude CEES depresses total IL-1alpha and related cytokines, does not affect PGE(2) release, and adverse changes associated with CEES-exposed EpiDerm are not ameliorated by these particular antagonists.	2-chloroethyl ethyl sulfide	12-16	interleukin 1 alpha	Homo sapiens	33-42
10857790-0	2000	Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage.	Hyaluronic Acid	15-25	interleukin 1 alpha	Homo sapiens	40-58
10912884-10	2000	The prevention of the lowering of plasma glutamine concentration allows an increased response of lymphocytes to ConA and LPS, as well as an increased production of IL-1 and 2, TNF-alpha, and IFN-gamma, possibly linked to the lower incidence of symptoms of infection (33.84%) reported by the supplemented athletes.	Glutamine	41-50	interleukin 1 alpha	Homo sapiens	164-174
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	interleukin 1 alpha	Homo sapiens	52-70
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	interleukin 1 alpha	Homo sapiens	72-81
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	interleukin 1 alpha	Homo sapiens	119-128
10924750-5	2000	Although the precise mechanism for chorioamnionitis-driven preterm labor mediated via cytokines is still unknown, both IL-1 and TNF-alpha along with IL-6 enhance prostaglandin production by human amnion cells, chorionic cells and decidual cells.	Prostaglandins	162-175	interleukin 1 alpha	Homo sapiens	119-123
10857790-7	2000	In IL-1-treated chondrocytes, extracellular hyaluronan decreased, while intracellular accumulation of hyaluronan was enhanced.	Hyaluronic Acid	44-54	interleukin 1 alpha	Homo sapiens	3-7
10857790-7	2000	In IL-1-treated chondrocytes, extracellular hyaluronan decreased, while intracellular accumulation of hyaluronan was enhanced.	Hyaluronic Acid	102-112	interleukin 1 alpha	Homo sapiens	3-7
10822086-0	2000	Effects of trovafloxacin on the IL-1-dependent activation of E-selectin in human endothelial cells in vitro.	trovafloxacin	11-24	interleukin 1 alpha	Homo sapiens	32-36
11294501-0	2000	Glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution.	N-Acetylneuraminic Acid	72-95	interleukin 1 alpha	Homo sapiens	19-37
11294501-0	2000	Glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution.	N-Acetylneuraminic Acid	72-95	interleukin 1 alpha	Homo sapiens	48-57
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	126-149	interleukin 1 alpha	Homo sapiens	90-94
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	126-149	interleukin 1 alpha	Homo sapiens	217-226
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	151-156	interleukin 1 alpha	Homo sapiens	90-94
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	151-156	interleukin 1 alpha	Homo sapiens	217-226
10822086-2	2000	The effect of two fluoroquinolones, ciprofloxacin (cipro) and trovafloxacin (trova), on the interleukin-1 (IL-1)-dependent activation of E-Selectin was studied on human umbilical vein endothelial cells (HUVEC) in vitro.	Fluoroquinolones	18-34	interleukin 1 alpha	Homo sapiens	92-111
10822086-2	2000	The effect of two fluoroquinolones, ciprofloxacin (cipro) and trovafloxacin (trova), on the interleukin-1 (IL-1)-dependent activation of E-Selectin was studied on human umbilical vein endothelial cells (HUVEC) in vitro.	Ciprofloxacin	36-49	interleukin 1 alpha	Homo sapiens	92-111
10822086-2	2000	The effect of two fluoroquinolones, ciprofloxacin (cipro) and trovafloxacin (trova), on the interleukin-1 (IL-1)-dependent activation of E-Selectin was studied on human umbilical vein endothelial cells (HUVEC) in vitro.	Ciprofloxacin	36-41	interleukin 1 alpha	Homo sapiens	92-111
10822086-2	2000	The effect of two fluoroquinolones, ciprofloxacin (cipro) and trovafloxacin (trova), on the interleukin-1 (IL-1)-dependent activation of E-Selectin was studied on human umbilical vein endothelial cells (HUVEC) in vitro.	trovafloxacin	62-75	interleukin 1 alpha	Homo sapiens	92-111
10748004-6	2000	LY294002 potentiates the activation of mitogen-activated protein kinases and stress-activated protein kinases by TNF and IL-1, suggesting Akt inhibits these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 alpha	Homo sapiens	121-125
10822086-2	2000	The effect of two fluoroquinolones, ciprofloxacin (cipro) and trovafloxacin (trova), on the interleukin-1 (IL-1)-dependent activation of E-Selectin was studied on human umbilical vein endothelial cells (HUVEC) in vitro.	trovafloxacin	62-67	interleukin 1 alpha	Homo sapiens	92-111
10821716-2	2000	Some compounds, which have a lower alkyl group at the 2-position of the gamma-sultam skeleton, showed potent inhibitory effects on both cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LO), as well as production of interleukin (IL)-1 in in vitro assays.	gamma-sultam	72-84	interleukin 1 alpha	Homo sapiens	211-229
10830246-7	2000	RESULTS: Activation of HUVEC with interleukin-1 or T cells resulted in a drastic accumulation of PGE2 in the supernatant.	Dinoprostone	97-101	interleukin 1 alpha	Homo sapiens	34-47
10768757-6	2000	PS particles induced a concentration-dependent increase in IL-1alpha after 24 h. In contrast, cultivation for 48 h, did not result in any measurable production of H2O2, irrespective of the type of stimulus.	Polystyrenes	0-2	interleukin 1 alpha	Homo sapiens	59-68
11324458-1	2000	AIM: To study the inhibitory effects of antisense interleukin-1 receptor associated kinase-2 (IRAK-2) oligodeoxynucleotide (ODN) on interleukin-1 (IL-1)-stimulated nuclear factor-kappa B (NF-kappa B) activation.	Oligodeoxyribonucleotides	124-127	interleukin 1 alpha	Homo sapiens	132-151
10734180-3	2000	In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production (IC(50) values = 0.12 and 0.35 microM, respectively).	SB 239063	67-76	interleukin 1 alpha	Homo sapiens	87-132
10702308-8	2000	These results suggest that IL-1 and ectopic expression of TAB1 both activate TAK1 via autophosphorylation of Ser-192.	Serine	109-112	interleukin 1 alpha	Homo sapiens	27-31
10705937-3	2000	RESULTS: Production of TNF-alpha, IL-1alpha, IL-1beta and IL-6 by PBMC and TNF-alpha by PBM were significantly lower in the patients with PD as compared to the control groups.	phytobacteriomycin	66-69	interleukin 1 alpha	Homo sapiens	34-43
10705937-3	2000	RESULTS: Production of TNF-alpha, IL-1alpha, IL-1beta and IL-6 by PBMC and TNF-alpha by PBM were significantly lower in the patients with PD as compared to the control groups.	phytobacteriomycin	66-69	interleukin 1 alpha	Homo sapiens	45-53
10696064-6	2000	The increase in SP-A mRNA was evident within 4 to 6 h. IL-1alpha increased the SP-A concentration in alveolar epithelial cells and in the culture medium within 20 h. In contrast, at 27 to 30 d of gestation and in newborns, IL-1alpha decreased SP-C, -B, and -A mRNA by means of 64 to 67%, 48 to 59%, and 12 to 15%, respectively.	sp-c	243-247	interleukin 1 alpha	Homo sapiens	55-64
10696064-9	2000	On Day 27, IL-1alpha accelerated the degradation of SP-B mRNA in the presence of actinomycin D.	Dactinomycin	81-94	interleukin 1 alpha	Homo sapiens	11-20
10735591-9	2000	CONCLUSIONS: IL-1 increases PG production by myometrium by increased COX-2 expression.	Prostaglandins	28-30	interleukin 1 alpha	Homo sapiens	13-17
10735591-10	2000	NS-398 completely blocks IL-1-induced PG production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 alpha	Homo sapiens	25-29
10735591-10	2000	NS-398 completely blocks IL-1-induced PG production.	Prostaglandins	38-40	interleukin 1 alpha	Homo sapiens	25-29
10735591-11	2000	With intrauterine infection, IL-1 may induce labor through the autocrine production of uterotonic PGs.	Phosphatidylglycerols	98-101	interleukin 1 alpha	Homo sapiens	29-33
10704258-7	2000	Ouabain induced the production of IL-1alpha, IL-1beta and IL-6, but not of TNF-alpha.	Ouabain	0-7	interleukin 1 alpha	Homo sapiens	34-43
10704258-9	2000	The production of IL-1alpha, and IL-6 was inhibited by amlodipine in a concentration-dependent manner and was significantly decreased at a concentration of 10 micromol/l.	Amlodipine	55-65	interleukin 1 alpha	Homo sapiens	18-27
10704258-12	2000	The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients.	Amlodipine	23-33	interleukin 1 alpha	Homo sapiens	63-72
10675242-7	2000	Compared to control monolayers, lipopolysaccharide, prostaglandin E2, IL-1alpha, and TNF-alpha decreased mucosal-to-serosal and net sodium and chloride fluxes and increased serosal-to-mucosal movement of sodium and unmeasured ions.	Sodium	132-138	interleukin 1 alpha	Homo sapiens	70-79
10675242-7	2000	Compared to control monolayers, lipopolysaccharide, prostaglandin E2, IL-1alpha, and TNF-alpha decreased mucosal-to-serosal and net sodium and chloride fluxes and increased serosal-to-mucosal movement of sodium and unmeasured ions.	Chlorides	143-151	interleukin 1 alpha	Homo sapiens	70-79
10675242-7	2000	Compared to control monolayers, lipopolysaccharide, prostaglandin E2, IL-1alpha, and TNF-alpha decreased mucosal-to-serosal and net sodium and chloride fluxes and increased serosal-to-mucosal movement of sodium and unmeasured ions.	Sodium	204-210	interleukin 1 alpha	Homo sapiens	70-79
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	14-23
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	14-23
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	31-40
11294501-4	2000	NeuAc-IL-1alpha exhibited a marked reduction in the activity to up-regulate serum IL-6, moderate reduction in the activities to up-regulate serum amyloid A and NOx.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	6-15
11294501-6	2000	In addition, tissue level of NeuAc-IL-1alpha was high compared to IL-1alpha.	N-Acetylneuraminic Acid	29-34	interleukin 1 alpha	Homo sapiens	35-44
11294501-7	2000	These results indicate that coupling with NeuAc enabled us to develop neo-IL-1 with selective activities in vivo and enhanced tissue level.	N-Acetylneuraminic Acid	42-47	interleukin 1 alpha	Homo sapiens	74-78
10820436-5	2000	Treatment of both NB cell lines with interleukin-1alpha (0.5 ng/ml), tumor necrosis factor alpha (100 U/ml), interferon gamma (200 U/ml), or their combinations increased monocyte adhesion to SK-N-SH and SK-N-MC.	sk-n-sh	191-198	interleukin 1 alpha	Homo sapiens	37-55
10820436-5	2000	Treatment of both NB cell lines with interleukin-1alpha (0.5 ng/ml), tumor necrosis factor alpha (100 U/ml), interferon gamma (200 U/ml), or their combinations increased monocyte adhesion to SK-N-SH and SK-N-MC.	sk-n-mc	203-210	interleukin 1 alpha	Homo sapiens	37-55
10820436-8	2000	In contrast, monocyte adhesion to IL-1alpha or IFNgamma treated SK-N-MC was only slightly inhibited with a combination of mAb to CD18 + VLA-4 and there was no inhibition at all to TNFalpha-treated SK-N-MC.	sk-n-mc	64-71	interleukin 1 alpha	Homo sapiens	34-43
10820436-8	2000	In contrast, monocyte adhesion to IL-1alpha or IFNgamma treated SK-N-MC was only slightly inhibited with a combination of mAb to CD18 + VLA-4 and there was no inhibition at all to TNFalpha-treated SK-N-MC.	sk-n-mc	197-204	interleukin 1 alpha	Homo sapiens	34-43
10896254-7	2000	Cycloheximide treatment of HUVEC slightly inhibited the IL-1alpha-induced expression of VEGF mRNA, and IL-1alpha may mediate, at least in part, VEGF expression in response to IL-1alpha.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	56-65
10748004-4	2000	Consistent with these biochemical observations, TNF and IL-1 reduce apoptosis caused by growth factor and serum deprivation, and this action is also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	interleukin 1 alpha	Homo sapiens	56-60
10823686-0	2000	Effects of sulfhydryl compounds on interleukin-1-induced vascular endothelial growth factor production in human synovial stromal cells.	Sulfhydryl Compounds	11-31	interleukin 1 alpha	Homo sapiens	35-48
10823686-1	2000	We investigated the effects of various sulfhydryl compounds on interleukin-1 (IL-1)-induced vascular endothelial growth factor (VEGF) production in human synovial stromal cells (HSSC).	Sulfhydryl Compounds	39-49	interleukin 1 alpha	Homo sapiens	63-82
10919016-5	2000	Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P &lt; 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells.	Nitrites	101-108	interleukin 1 alpha	Homo sapiens	17-27
10800933-6	2000	In addition, several potassium channel inhibitors such as CsCl, tetraethylammonium, and 4-aminopyridine as well as nigericin inhibited astrocyte iNOS expression induced by IL-1/IFNgamma.	cesium chloride	58-62	interleukin 1 alpha	Homo sapiens	172-185
10800933-6	2000	In addition, several potassium channel inhibitors such as CsCl, tetraethylammonium, and 4-aminopyridine as well as nigericin inhibited astrocyte iNOS expression induced by IL-1/IFNgamma.	Tetraethylammonium	64-82	interleukin 1 alpha	Homo sapiens	172-185
10800933-6	2000	In addition, several potassium channel inhibitors such as CsCl, tetraethylammonium, and 4-aminopyridine as well as nigericin inhibited astrocyte iNOS expression induced by IL-1/IFNgamma.	4-Aminopyridine	88-103	interleukin 1 alpha	Homo sapiens	172-185
10800933-6	2000	In addition, several potassium channel inhibitors such as CsCl, tetraethylammonium, and 4-aminopyridine as well as nigericin inhibited astrocyte iNOS expression induced by IL-1/IFNgamma.	Nigericin	115-124	interleukin 1 alpha	Homo sapiens	172-185
10733939-2	2000	Interleukin-1 (IL-1) beta release from M&amp;phi; in response to LPS, appears to be mediated by the autocrine/paracrine release of ATP via P2X7 receptor activation.	Adenosine Monophosphate	41-44	interleukin 1 alpha	Homo sapiens	0-13
10733939-2	2000	Interleukin-1 (IL-1) beta release from M&amp;phi; in response to LPS, appears to be mediated by the autocrine/paracrine release of ATP via P2X7 receptor activation.	Adenosine Triphosphate	131-134	interleukin 1 alpha	Homo sapiens	0-13
10733939-4	2000	To determine whether CD39 modulates ATP-mediated release of IL-1 from EC, we stimulated human EC with LPS and measured levels of ATP secretion and IL-1 release.	Adenosine Triphosphate	36-39	interleukin 1 alpha	Homo sapiens	60-64
10733939-5	2000	LPS triggered ATP secretion from EC that was soon followed by IL-1alpha release.	Adenosine Triphosphate	14-17	interleukin 1 alpha	Homo sapiens	62-71
11324458-1	2000	AIM: To study the inhibitory effects of antisense interleukin-1 receptor associated kinase-2 (IRAK-2) oligodeoxynucleotide (ODN) on interleukin-1 (IL-1)-stimulated nuclear factor-kappa B (NF-kappa B) activation.	Oligodeoxyribonucleotides	102-122	interleukin 1 alpha	Homo sapiens	132-151
10749772-2	2000	The purpose of this study was to determine if gender- or age-related differences exist in the sensitivity of IL-1-producing cells to hydrocortisone.	Hydrocortisone	133-147	interleukin 1 alpha	Homo sapiens	109-113
10749772-5	2000	Hydrocortisone decreased soluble IL-1 receptor type II (sIL-1RII) secretion by unstimulated cells (P = 0.	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	33-37
10772110-5	2000	RESULTS: Human recombinant IL-1alpha (40 ng/ml) increased the amount of labeled GAG released and decreased labeled and total GAG remaining in explants, and IL-1alpha decreased mitogenic response.	Glycosaminoglycans	80-83	interleukin 1 alpha	Homo sapiens	27-36
10772110-5	2000	RESULTS: Human recombinant IL-1alpha (40 ng/ml) increased the amount of labeled GAG released and decreased labeled and total GAG remaining in explants, and IL-1alpha decreased mitogenic response.	Glycosaminoglycans	125-128	interleukin 1 alpha	Homo sapiens	27-36
10770206-0	2000	Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells.	Progesterone	0-12	interleukin 1 alpha	Homo sapiens	81-99
10770206-2	2000	Several laboratories have shown that inflammatory cytokines, including interleukin-lalpha (IL-1alpha), can oppose progesterone suppression of MMPs in the human endometrium.	Progesterone	114-126	interleukin 1 alpha	Homo sapiens	91-100
10770206-5	2000	Although IL-1alpha is a potent stimulator of MMP-3 in proliferative phase endometrium in organ culture, we demonstrate that progesterone exposure in vivo reduces IL-1alpha stimulation of MMP-3 in secretory phase tissue.	Progesterone	124-136	interleukin 1 alpha	Homo sapiens	162-171
10770206-6	2000	This loss of sensitivity to IL-1alpha was duplicated in isolated stromal cells treated with progesterone in vitro, and IL-1alpha stimulation of MMP-3 returned in a dose-dependent manner with progesterone withdrawal.	Progesterone	92-104	interleukin 1 alpha	Homo sapiens	28-37
10770206-7	2000	The antiprogestin, onapristone, partially blocked the ability of progesterone to prevent stimulation of MMP-3 by IL-1alpha.	onapristone	19-30	interleukin 1 alpha	Homo sapiens	113-122
10863961-5	2000	In contrast, 45Ca release induced by IL-1 alpha, IL-1 beta, thrombin and bradykinin was significantly reduced by indomethacin, whereas the effects of PTH and PTHrP were unaffected by indomethacin.	Indomethacin	113-125	interleukin 1 alpha	Homo sapiens	37-47
10729317-3	2000	In humans, prostaglandin E(2) (PGE(2)) enhances while interleukin (IL)-1 inhibits the decidualizing effect of progesterone.	Progesterone	110-122	interleukin 1 alpha	Homo sapiens	54-72
10882101-5	2000	These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway.	tab2	21-25	interleukin 1 alpha	Homo sapiens	107-111
10876805-3	2000	This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses.	monoamines	193-203	interleukin 1 alpha	Homo sapiens	140-153
10876805-3	2000	This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses.	Catecholamines	205-219	interleukin 1 alpha	Homo sapiens	140-153
10876805-3	2000	This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses.	Serotonin	224-233	interleukin 1 alpha	Homo sapiens	140-153
10735591-0	2000	Interleukin-1 stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 expression.	Prostaglandins	39-52	interleukin 1 alpha	Homo sapiens	0-13
10735591-2	2000	The objective of this study was to examine the effect of interleukin-1 (IL-1) and the cyclooxygenase-2 (COX-2) inhibitor, NS-398, on myometrial prostaglandin (PG) production and COX-2 expression.	Prostaglandins	159-161	interleukin 1 alpha	Homo sapiens	57-77
10735591-6	2000	RESULTS: IL-1 increased PG production beginning at 6 hr, COX-2 protein increased beginning at 4 hr and continued to increase at 24 hr.	Prostaglandins	24-26	interleukin 1 alpha	Homo sapiens	9-13
10679281-3	2000	The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP.	polyg-mdp	4-13	interleukin 1 alpha	Homo sapiens	84-102
10679281-3	2000	The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP.	Acetylmuramyl-Alanyl-Isoglutamine	10-13	interleukin 1 alpha	Homo sapiens	84-102
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	interleukin 1 alpha	Homo sapiens	192-196
10652294-0	2000	Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression.	kappabalpha	95-106	interleukin 1 alpha	Homo sapiens	15-28
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	Hexosamines	42-53	interleukin 1 alpha	Homo sapiens	153-157
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	Glucosamine	54-65	interleukin 1 alpha	Homo sapiens	153-157
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	Glucosamine	67-71	interleukin 1 alpha	Homo sapiens	153-157
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	mannosamine	77-88	interleukin 1 alpha	Homo sapiens	153-157
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	mannosamine	90-94	interleukin 1 alpha	Homo sapiens	153-157
10640399-5	2000	After 6 days of culture in 10 ng/ml IL-1 plus ManN, mechanical testing of explants in confined compression demonstrated that ManN inhibited the IL-1alpha-induced degradation in tissue equilibrium modulus, dynamic stiffness, streaming potential, and hydraulic permeability, in a dose-dependent fashion, with peak inhibition ( approximately 75-100% inhibition) reached by a concentration of 1.35 mM.	mannosamine	125-129	interleukin 1 alpha	Homo sapiens	36-40
10640399-5	2000	After 6 days of culture in 10 ng/ml IL-1 plus ManN, mechanical testing of explants in confined compression demonstrated that ManN inhibited the IL-1alpha-induced degradation in tissue equilibrium modulus, dynamic stiffness, streaming potential, and hydraulic permeability, in a dose-dependent fashion, with peak inhibition ( approximately 75-100% inhibition) reached by a concentration of 1.35 mM.	mannosamine	125-129	interleukin 1 alpha	Homo sapiens	144-153
10761626-9	2000	In the case of IL-1, and TNF-alpha low concentrations of cadmium chloride increase the expression of these genes, whereas this effect is less noticeable with higher amounts of cadmium.	Cadmium Chloride	57-73	interleukin 1 alpha	Homo sapiens	15-19
10761626-9	2000	In the case of IL-1, and TNF-alpha low concentrations of cadmium chloride increase the expression of these genes, whereas this effect is less noticeable with higher amounts of cadmium.	Cadmium	57-64	interleukin 1 alpha	Homo sapiens	15-19
10690884-0	2000	Interleukin-1 receptor antagonist ribonucleic acid and protein expression by cultured Graves" and normal orbital fibroblasts is differentially modulated by dexamethasone and irradiation.	Dexamethasone	156-169	interleukin 1 alpha	Homo sapiens	0-13
10648120-10	2000	However, the TiO(2)-LPS conjugate produced a two-to-three-fold, significant increase in the intestinal secretion of IL-1.	tio(2)-lps	13-23	interleukin 1 alpha	Homo sapiens	116-120
10690516-2	2000	Interleukin (IL)-1 alpha, IL-6, and IL-12 induction by ONO-4007 activates cytotoxic natural killer cells to up-regulate IFN-gamma and nitric oxide synthase activity.	ONO 4007	55-63	interleukin 1 alpha	Homo sapiens	0-24
10617995-4	2000	These doses of n-3 fatty acids are associated with significant reductions in the release of leukotriene B(4) from stimulated neutrophils and of interleukin 1 from monocytes.	Fatty Acids, Omega-3	15-30	interleukin 1 alpha	Homo sapiens	144-157
10623619-3	2000	Parthenolide, a sesquiterpene lactone found in many medical plants, is an inhibitor of IL-1-type cytokine signaling that blocks the activation of NF-kappaB.	parthenolide	0-12	interleukin 1 alpha	Homo sapiens	87-91
10623619-3	2000	Parthenolide, a sesquiterpene lactone found in many medical plants, is an inhibitor of IL-1-type cytokine signaling that blocks the activation of NF-kappaB.	sesquiterpene lactone	16-37	interleukin 1 alpha	Homo sapiens	87-91
10912190-6	2000	By its capability to reduce IL-1 effects and to stimulate TGF-beta expression in cultured articular chondrocytes, diacerein could favour anabolic processes in the OA cartilage and, hence may contribute to delay the progression of the disease.	diacerein	114-123	interleukin 1 alpha	Homo sapiens	28-32
11268367-14	2000	IL-1 alpha-induced stimulation of PRL release is also mediated by intrahypothlamic action of NO, which inhibits release of the PRL-inhibiting hormone dopamine.	Dopamine	150-158	interleukin 1 alpha	Homo sapiens	0-10
10774464-3	2000	Superantigens such as pyrogenic exotoxin A interact with monocytes and T lymphocytes in unique ways, resulting in T-cell proliferation and watershed production of monokines (e.g. tumor necrosis factor alpha, interleukin 1, interleukin 6), and lymphokines (e.g. tumor necrosis factor beta, interleukin 2, and gamma-interferon).	pyrogenic exotoxin a	22-42	interleukin 1 alpha	Homo sapiens	208-221
10912912-5	2000	We further show that pretreatment of human internal thoracic artery and cardiac atrial endothelium with the proinflammatory cytokines interleukin-1-alpha and -beta led to a significant increase in both the expression of the mu transcript and in morphine-stimulated nitric oxide release measured amperometrically.	Morphine	245-253	interleukin 1 alpha	Homo sapiens	134-163
10606930-4	2000	RESULTS: The results showed that TNF alpha, IL-1 alpha and PAF induced serine phosphorylation of MKK3 and MKK6, and p38 MAP kinase activation in BECs.	Serine	71-77	interleukin 1 alpha	Homo sapiens	44-54
10606930-5	2000	SB 203580 inhibited p38 MAP kinase activity and RANTES and GM-CSF production by TNF alpha-, IL-1 alpha- or PAF-stimulated human BECs.	SB 203580	0-9	interleukin 1 alpha	Homo sapiens	92-102
10834235-4	2000	Biochemical and immunochemical analysis of the tissues revealed increased levels of pro-inflammatory cytokines as well as increased levels of hydrogen peroxide and decreased activity of catalase Increasing concentrations of hydrogen peroxide also caused increases in macrophage release of pro-inflammatory cytokine (IL-1).	Hydrogen Peroxide	224-241	interleukin 1 alpha	Homo sapiens	289-320
10912912-5	2000	We further show that pretreatment of human internal thoracic artery and cardiac atrial endothelium with the proinflammatory cytokines interleukin-1-alpha and -beta led to a significant increase in both the expression of the mu transcript and in morphine-stimulated nitric oxide release measured amperometrically.	Nitric Oxide	265-277	interleukin 1 alpha	Homo sapiens	134-163
10611258-5	2000	Addition of the NFkappaB inhibitor SN50 (5 microg/ml) to confluent cultures of endometrial epithelial cells inhibited interleukin (IL)-1alpha (10 ng/ml) and tumour necrosis factor alpha (TNFalpha) (10 ng/ml) stimulated IL-6 (P &lt; 0.001 and P &lt; 0.01 respectively) and LIF (P &lt; 0.01 and P &lt; 0.05 respectively) production.	SN50	35-39	interleukin 1 alpha	Homo sapiens	118-141
10671814-3	2000	Under a serum-free culture condition, an increase in PGE(2) production by IL-1alpha and IL-1beta was observed at concentrations of 10 and 100 ng/ml compared to control cultures.	Prostaglandins E	53-56	interleukin 1 alpha	Homo sapiens	74-83
10769429-10	2000	D-hormone preparations (alfacalcidol, calcitriol) possess immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12.	alfacalcidol	24-36	interleukin 1 alpha	Homo sapiens	132-136
10611258-6	2000	The proteasome inhibitor MG132 (0.3 and 3 micromol/l) also caused a dose-dependent decrease in IL-1alpha and TNFalpha-stimulated IL-6 (P &lt; 0.001 and P &lt; 0.001 respectively) and leukaemia inhibitory factor (LIF) (P &lt; 0.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	25-30	interleukin 1 alpha	Homo sapiens	95-104
10769429-10	2000	D-hormone preparations (alfacalcidol, calcitriol) possess immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12.	Calcitriol	38-48	interleukin 1 alpha	Homo sapiens	132-136
11155801-2	2000	For example, it has been shown that IL-1 is the main mediator of the increase in ACTH and corticosterone blood levels detected in models of viral infection and bacterial endotoxins.	Corticosterone	90-104	interleukin 1 alpha	Homo sapiens	36-40
10569731-6	1999	Enzymatic activity of CD26 induced by IL-1alpha on fibroblasts was determined colorimetrically in terms of Gly-Pro hydrolysis of a synthetic chromogenic substrate, Gly-Pro p-nitroanilide.	Glycine	107-110	interleukin 1 alpha	Homo sapiens	38-47
10574930-5	1999	Despite this difference, FK506-induced IkappaBalpha degradation was dependent on the N-terminal Ser-32 and Ser-36 phosphorylation sites and was mediated by proteasomes, as is the case for IL-1-induced IkappaBalpha degradation.	Tacrolimus	25-30	interleukin 1 alpha	Homo sapiens	188-192
10616001-5	1999	RESULTS: Fluoxetine (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) inhibited NO release by 56%, 62%, and 71%, respectively, in the media of synovial cells stimulated by interleukin-1alpha (IL-1alpha; 1 ng/ml) plus tumor necrosis factor alpha (TNFalpha; 30 ng/ml).	Fluoxetine	9-19	interleukin 1 alpha	Homo sapiens	168-186
10616001-5	1999	RESULTS: Fluoxetine (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) inhibited NO release by 56%, 62%, and 71%, respectively, in the media of synovial cells stimulated by interleukin-1alpha (IL-1alpha; 1 ng/ml) plus tumor necrosis factor alpha (TNFalpha; 30 ng/ml).	Fluoxetine	9-19	interleukin 1 alpha	Homo sapiens	188-197
10616001-7	1999	Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) significantly (P&lt;0.05) inhibited PGE2 release in the media of human synovial cells in the presence of IL-1alpha plus TNFalpha, in a dose-dependent manner (up to 88% inhibition).	Fluoxetine	0-10	interleukin 1 alpha	Homo sapiens	180-189
10616001-7	1999	Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) significantly (P&lt;0.05) inhibited PGE2 release in the media of human synovial cells in the presence of IL-1alpha plus TNFalpha, in a dose-dependent manner (up to 88% inhibition).	Amitriptyline	15-28	interleukin 1 alpha	Homo sapiens	180-189
10616001-7	1999	Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) significantly (P&lt;0.05) inhibited PGE2 release in the media of human synovial cells in the presence of IL-1alpha plus TNFalpha, in a dose-dependent manner (up to 88% inhibition).	Dinoprostone	111-115	interleukin 1 alpha	Homo sapiens	180-189
10586114-2	1999	The IL-3- and IL-1-mediated proliferation were both inhibited by the specific p38 and MEK1 inhibitors SB203580 and PD98059, respectively.	SB 203580	102-110	interleukin 1 alpha	Homo sapiens	14-18
10586114-2	1999	The IL-3- and IL-1-mediated proliferation were both inhibited by the specific p38 and MEK1 inhibitors SB203580 and PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	115-122	interleukin 1 alpha	Homo sapiens	14-18
10565567-0	1999	Antisense IRAK-2 oligonucleotide blocks IL-1-stimulated NF-kappaB activation and ICAM-1 expression in cultured endothelial cells.	Oligonucleotides	17-32	interleukin 1 alpha	Homo sapiens	40-44
11026134-7	2000	It is suggested that initial high level of IL-1 production could serve as a predictor of efficiency of therapy with akatinol memantine in patients with early onset of Alzheimer"s disease.	akatinol memantine	116-134	interleukin 1 alpha	Homo sapiens	43-47
10586114-7	1999	The IL-1-enhanced IL-6 protein secretion was strongly reduced by SB203580 and PD98059.	SB 203580	65-73	interleukin 1 alpha	Homo sapiens	4-8
10586114-7	1999	The IL-1-enhanced IL-6 protein secretion was strongly reduced by SB203580 and PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	78-85	interleukin 1 alpha	Homo sapiens	4-8
10569731-6	1999	Enzymatic activity of CD26 induced by IL-1alpha on fibroblasts was determined colorimetrically in terms of Gly-Pro hydrolysis of a synthetic chromogenic substrate, Gly-Pro p-nitroanilide.	gly-pro p-nitroanilide	164-186	interleukin 1 alpha	Homo sapiens	38-47
10569731-7	1999	Among various inhibitors tested, diprotin A and phenylmethylsulfonyl fluoride inhibited the enzymatic activity, suggesting that the enzyme induced by IL-1alpha was DPPIV.	diprotin A	33-43	interleukin 1 alpha	Homo sapiens	150-159
10569731-7	1999	Among various inhibitors tested, diprotin A and phenylmethylsulfonyl fluoride inhibited the enzymatic activity, suggesting that the enzyme induced by IL-1alpha was DPPIV.	Phenylmethylsulfonyl Fluoride	48-77	interleukin 1 alpha	Homo sapiens	150-159
10569809-12	1999	Furthermore, the observed inhibitory effects of silymarin on COX-2 and IL-1alpha should be further explored to develop preventive strategies against those cancers in which these molecular targets play one of the causative roles, such as non-melanoma skin, colon, and breast cancers in humans.	Silymarin	48-57	interleukin 1 alpha	Homo sapiens	71-80
10613098-2	1999	Lipopolysaccarides and cytokines, like tumor necrosis factor, interleukin-1 and interferon-gamma, have been shown to induce iNOS in the endothelium, vascular smooth muscle cells, macrophages and different parenchymal cells.	lipopolysaccarides	0-18	interleukin 1 alpha	Homo sapiens	62-75
20654562-15	1999	Our data demonstrate that divergent IL-1alpha and IL-8 release profiles and corresponding mRNA upregulation characterize the response to the tested irritants and DNCB.	Dinitrochlorobenzene	162-166	interleukin 1 alpha	Homo sapiens	36-45
10614876-2	1999	We have established vascular smooth muscle cells culture conditions in which heparin, in the presence of endothelial cell growth supplement, promotes cell proliferation and inhibits interleukin-1 and matrix protein expression.	Heparin	77-84	interleukin 1 alpha	Homo sapiens	182-195
10555884-5	1999	RESULTS: A significant decrease of IL-1, IL-6, TNF-alpha, and beta2m was observed after 30 days, persisting after 90 days in the AL group, but with no significant variation in the placebo group.	Alendronate	129-131	interleukin 1 alpha	Homo sapiens	35-39
10616034-9	1999	Since fish oil and gamma linolenic acid (GLA) suppress IL-1 production by stimulated monocytes, they conceivably could exert this effect in the brain as well; the comparatively low prevalence of AD in elderly Japanese is intriguing in this regard.	Fish Oils	6-14	interleukin 1 alpha	Homo sapiens	55-59
10616034-9	1999	Since fish oil and gamma linolenic acid (GLA) suppress IL-1 production by stimulated monocytes, they conceivably could exert this effect in the brain as well; the comparatively low prevalence of AD in elderly Japanese is intriguing in this regard.	gamma-Linolenic Acid	19-39	interleukin 1 alpha	Homo sapiens	55-59
10616034-9	1999	Since fish oil and gamma linolenic acid (GLA) suppress IL-1 production by stimulated monocytes, they conceivably could exert this effect in the brain as well; the comparatively low prevalence of AD in elderly Japanese is intriguing in this regard.	gamma-Linolenic Acid	41-44	interleukin 1 alpha	Homo sapiens	55-59
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	Sugars	10-16	interleukin 1 alpha	Homo sapiens	146-155
10531207-10	1999	This conclusion was supported by evidence that N(G)-monomethyl-L-arginine, a competitive inhibitor of inducible NOS activity, is able to block the inhibitory action of IL-1 on IFN-gamma-induced bacteriostasis.	omega-N-Methylarginine	47-73	interleukin 1 alpha	Homo sapiens	168-172
10674720-8	1999	However, statistically significant amount of expressions of IL-1alpha, -1beta, and -6 were observed after the early days of transplantation of human RPE or IL-1alpha, -1beta, and TNF alpha of rat IPE, if we compare them to vehicle-only injection.	ipe	196-199	interleukin 1 alpha	Homo sapiens	60-85
10669911-12	1999	Treatment with citicoline tended to reduce serum IL-1 beta levels, mainly after 4 weeks of administration, with no modified blood histamine content.	Cytidine Diphosphate Choline	15-25	interleukin 1 alpha	Homo sapiens	49-58
10674720-8	1999	However, statistically significant amount of expressions of IL-1alpha, -1beta, and -6 were observed after the early days of transplantation of human RPE or IL-1alpha, -1beta, and TNF alpha of rat IPE, if we compare them to vehicle-only injection.	ipe	196-199	interleukin 1 alpha	Homo sapiens	60-77
10515886-4	1999	The ability of SAEC to ingest apoptotic eosinophils was enhanced by interleukin-1alpha (IL-1alpha) or tumor necrosis factor alpha (TNFalpha) in a time- and concentration-dependent fashion.	saec	15-19	interleukin 1 alpha	Homo sapiens	68-86
10506586-9	1999	When cells were incubated in 25 mM glucose to mimic the diabetic state, IL-1beta induction was inhibited in all cases, but to a significantly lesser extent with the 14-repeat allele.	Glucose	35-42	interleukin 1 alpha	Homo sapiens	72-80
10515886-4	1999	The ability of SAEC to ingest apoptotic eosinophils was enhanced by interleukin-1alpha (IL-1alpha) or tumor necrosis factor alpha (TNFalpha) in a time- and concentration-dependent fashion.	saec	15-19	interleukin 1 alpha	Homo sapiens	88-97
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	Amino Sugars	4-16	interleukin 1 alpha	Homo sapiens	146-155
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	Glucosamine	17-28	interleukin 1 alpha	Homo sapiens	146-155
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	Acetylglucosamine	30-50	interleukin 1 alpha	Homo sapiens	146-155
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	Galactosamine	56-69	interleukin 1 alpha	Homo sapiens	146-155
10515886-7	1999	The amino sugars glucosamine, n-acetyl glucosamine, and galactosamine significantly inhibited uptake of apoptotic eosinophils by both resting and IL-1alpha-stimulated SAEC, in contrast to the parent sugars glucose, galactose, mannose, and fucose.	saec	167-171	interleukin 1 alpha	Homo sapiens	146-155
10530917-8	1999	Nicotine and arecoline therefore significantly increased IL-1 alpha and -1 beta secretions and the surface expression of ICAM-1 in KB CCL17 cells.	Nicotine	0-8	interleukin 1 alpha	Homo sapiens	57-79
10530917-8	1999	Nicotine and arecoline therefore significantly increased IL-1 alpha and -1 beta secretions and the surface expression of ICAM-1 in KB CCL17 cells.	Arecoline	13-22	interleukin 1 alpha	Homo sapiens	57-79
10516167-2	1999	The present study tested the hypothesis that low O(2) tension directly stimulates human VSMC proliferation by inducing them to produce interleukin (IL)-1, a potent autocrine growth factor for human VSMC.	Oxygen	49-53	interleukin 1 alpha	Homo sapiens	135-153
10516167-4	1999	Levels of IL-1alpha and IL-1beta mRNA increased in human VSMC after 24-48 h of incubation in low O(2) compared with levels in normoxic cells and then decreased upon subsequent reoxygenation.	Oxygen	97-101	interleukin 1 alpha	Homo sapiens	10-19
10533294-5	1999	METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs.	Hydrogen Peroxide	36-53	interleukin 1 alpha	Homo sapiens	116-120
10509643-1	1999	PURPOSE: To correlate tear fluorescein clearance with interleukin-1alpha (IL-1alpha) concentration and gelatinase B (matrix metalloproteinase [MMP]-9) activity in the tear fluid of patients with ocular rosacea and normal control subjects.	Fluorescein	27-38	interleukin 1 alpha	Homo sapiens	54-72
10509643-1	1999	PURPOSE: To correlate tear fluorescein clearance with interleukin-1alpha (IL-1alpha) concentration and gelatinase B (matrix metalloproteinase [MMP]-9) activity in the tear fluid of patients with ocular rosacea and normal control subjects.	Fluorescein	27-38	interleukin 1 alpha	Homo sapiens	74-83
10490998-5	1999	Here, we report that other inflammatory cytokines (IL-1 alpha, IL-1 beta, and IL-6) are also neuroprotective to excessive NMDA challenge in our system.	N-Methylaspartate	122-126	interleukin 1 alpha	Homo sapiens	51-61
10547156-7	1999	Poly-L-lysine, but not poly-L-glutamic acid dose-dependently increased the urinary excretion of IL-1alpha.	Lysine	0-13	interleukin 1 alpha	Homo sapiens	96-105
10533294-5	1999	METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs.	Hydrogen Peroxide	55-59	interleukin 1 alpha	Homo sapiens	116-120
10533294-5	1999	METHODS: In this study, we measured hydrogen peroxide (H2O2) and superoxide anion (O2-) levels after stimulation by IL-1 plus IL-6 in cultured HMCs.	Superoxides	57-59	interleukin 1 alpha	Homo sapiens	116-120
10533294-9	1999	RESULTS: Both 100 microM H2O2 and supernatants of HMCs stimulated by IL-1 10 U/ml plus IL-6 1,000 U/ml caused similar glomerular damage, including blebbing and sloughing of endothelial cells, and denuded basement membrane in glomeruli.	Hydrogen Peroxide	25-29	interleukin 1 alpha	Homo sapiens	69-73
10628361-5	1999	Ponalrestat inhibited the production of interleukin-1 (IL-1) from human monocytes stimulated by Lipopolysaccharide (LPS) in vitro, and also suppressed LPS-induced increase of IL-1 in the blood in mice.	ponalrestat	0-11	interleukin 1 alpha	Homo sapiens	40-53
11798701-3	1999	In the present study the concentration of interleukin-1 in the brain, thymus and blood was investigated to reveal the mechanism of CNS dysfunction in MG. METHODS: The concentration of interleukin-1 in brain, thymus and blood was detected after establishing the experimental MG model of central nervous system dysfunction induced by injection of AChRab purified from MG sera into the rat cerebral ventricular system.	achrab	345-351	interleukin 1 alpha	Homo sapiens	42-55
11798701-3	1999	In the present study the concentration of interleukin-1 in the brain, thymus and blood was investigated to reveal the mechanism of CNS dysfunction in MG. METHODS: The concentration of interleukin-1 in brain, thymus and blood was detected after establishing the experimental MG model of central nervous system dysfunction induced by injection of AChRab purified from MG sera into the rat cerebral ventricular system.	achrab	345-351	interleukin 1 alpha	Homo sapiens	184-197
11798701-4	1999	RESULTS: Interleukin-1 level in brain, thymus and blood started to increase one week after injection of AChRab.	achrab	104-110	interleukin 1 alpha	Homo sapiens	9-22
10628361-5	1999	Ponalrestat inhibited the production of interleukin-1 (IL-1) from human monocytes stimulated by Lipopolysaccharide (LPS) in vitro, and also suppressed LPS-induced increase of IL-1 in the blood in mice.	ponalrestat	0-11	interleukin 1 alpha	Homo sapiens	55-59
10628361-5	1999	Ponalrestat inhibited the production of interleukin-1 (IL-1) from human monocytes stimulated by Lipopolysaccharide (LPS) in vitro, and also suppressed LPS-induced increase of IL-1 in the blood in mice.	ponalrestat	0-11	interleukin 1 alpha	Homo sapiens	175-179
10479405-2	1999	It has been demonstrated that interleukin 1 (IL-1) potentiates the cytotoxic effect of CDDP and that IL-6 decreases cytotoxicity by inhibition of apoptosis in cancer cells.	Cisplatin	87-91	interleukin 1 alpha	Homo sapiens	30-49
10495130-13	1999	Prostaglandin estradiol (PGE2) levels were measured and found to be greatly increased in the coculture compared with ST-2 cells or hemopoietic cells alone, consistent with evidence that IL-1 action in osteoclastogenesis is mediated by PGE2.	prostaglandin estradiol	0-23	interleukin 1 alpha	Homo sapiens	186-190
10495130-13	1999	Prostaglandin estradiol (PGE2) levels were measured and found to be greatly increased in the coculture compared with ST-2 cells or hemopoietic cells alone, consistent with evidence that IL-1 action in osteoclastogenesis is mediated by PGE2.	Dinoprostone	235-239	interleukin 1 alpha	Homo sapiens	186-190
10479405-9	1999	IL-6 did not influence the sensitivity towards CDDP of either wt or resistant cells, while IL-1alpha and IL-1beta enhanced sensitivity of resistant cells to CDDP.	Cisplatin	157-161	interleukin 1 alpha	Homo sapiens	91-100
10815993-0	1999	In vitro biological activities of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid.	N-Acetylneuraminic Acid	106-129	interleukin 1 alpha	Homo sapiens	53-71
10815993-1	1999	In the previous study, N-acetylneuraminic acid (NANA) with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its biological activities, and to develop IL-1 with less deleterious effects.	N-Acetylneuraminic Acid	23-46	interleukin 1 alpha	Homo sapiens	118-127
10815993-1	1999	In the previous study, N-acetylneuraminic acid (NANA) with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its biological activities, and to develop IL-1 with less deleterious effects.	N-Acetylneuraminic Acid	23-46	interleukin 1 alpha	Homo sapiens	118-122
10815993-2	1999	In this study we examined a variety of IL-1 activities in vitro, including proliferative effect on T cells, antiproliferative effect on myeloid leukemic cells and melanoma cells, stimulatory effects on IL-6 synthesis by melanoma cells and PGE2 synthesis by fibroblast cells.	Dinoprostone	239-243	interleukin 1 alpha	Homo sapiens	39-43
10467228-7	1999	Dexamethasone markedly suppressed basal production of interleukin (IL)-6 and IL-11 and that stimulated by parathyroid hormone (PTH), IL-1alpha, or tumour necrosis factor-alpha in a dose-dependent manner.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	133-142
10453033-3	1999	Northern blot analyses showed that Gal beta 1-4GlcNAc alpha 2, 6-sialyltransferase (ST6N) mRNA was up-regulated in cultured HUVEC by IL-1 or IL-4 alone, but that the expression was enhanced by costimulation, whereas the level of Gal beta 1-4GlcNAc/Gal beta 1-3GalNAc alpha2,3-sialyltransferase (ST3ON) mRNA was unchanged.	4glcnac	46-53	interleukin 1 alpha	Homo sapiens	133-137
10453033-3	1999	Northern blot analyses showed that Gal beta 1-4GlcNAc alpha 2, 6-sialyltransferase (ST6N) mRNA was up-regulated in cultured HUVEC by IL-1 or IL-4 alone, but that the expression was enhanced by costimulation, whereas the level of Gal beta 1-4GlcNAc/Gal beta 1-3GalNAc alpha2,3-sialyltransferase (ST3ON) mRNA was unchanged.	1-4glcnac	44-53	interleukin 1 alpha	Homo sapiens	133-137
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	Sialic Acids	46-58	interleukin 1 alpha	Homo sapiens	64-68
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	2,3-linked	35-45	interleukin 1 alpha	Homo sapiens	64-68
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	N-Acetylneuraminic Acid	46-57	interleukin 1 alpha	Homo sapiens	64-68
10542977-5	1999	As it has been previously reported that IL-1 and TGF-beta stimulate prostaglandin E2 (PGE2) release from lung fibroblasts, we investigate here the role of endogenous PGE2 and the direct effects of the two inhibitors of prostaglandin synthesis, indomethacin and dexamethasone, on IL-11 production by human lung fibroblasts.	Dinoprostone	68-84	interleukin 1 alpha	Homo sapiens	40-44
10454683-11	1999	CONCLUSION: Stimulation of human myometrial cells with interleukin 1 leads to rapid activation of the transcription factor NF-kappaB, which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis.	Prostaglandins	242-255	interleukin 1 alpha	Homo sapiens	55-68
10433808-8	1999	PGE(2)(1 microM or 10 nM) reduces marrow stromal cell IL-8 synthesis in response to IL-1alpha or TNF-alpha.	Dinoprostone	0-6	interleukin 1 alpha	Homo sapiens	84-93
10400621-8	1999	Formation of the complex was dependent on cell interaction with the heparin binding region in fibronectin and required IL-1/type I IL-1 receptor binding.	Heparin	68-75	interleukin 1 alpha	Homo sapiens	119-123
10400621-8	1999	Formation of the complex was dependent on cell interaction with the heparin binding region in fibronectin and required IL-1/type I IL-1 receptor binding.	Heparin	68-75	interleukin 1 alpha	Homo sapiens	131-135
10400621-9	1999	This report demonstrates the recruitment of a heparan sulfate to the IL-1 receptor complex, following attachment to fibronectin, which correlates with alterations in receptor function.	Heparitin Sulfate	46-61	interleukin 1 alpha	Homo sapiens	69-73
10400621-10	1999	The data suggest that the heparan sulfate constitutes an attachment regulated component of the IL-1 receptor complex with the role of mediating matrix regulation of IL-1 responses.	Heparitin Sulfate	26-41	interleukin 1 alpha	Homo sapiens	95-99
10400621-10	1999	The data suggest that the heparan sulfate constitutes an attachment regulated component of the IL-1 receptor complex with the role of mediating matrix regulation of IL-1 responses.	Heparitin Sulfate	26-41	interleukin 1 alpha	Homo sapiens	165-169
10429980-7	1999	This neuropeptide, which has an anti-inflammatory activity (notably through production of IL-10, antagonism of IL-1 and inhibition of the chemotaxis of polymorphonuclear leukocytes), thus plays a role in the anti-inflammatory action of minocycline.	Minocycline	236-247	interleukin 1 alpha	Homo sapiens	90-94
10443472-0	1999	Dexamethasone inhibits collagen degradation induced by the combination of interleukin-1 and plasminogen in cartilage explant culture.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	74-87
10443472-4	1999	Dexamethasone clearly blocked collagen degradation induced by the combination of interleukin-1 (IL-1) and plasminogen at the concentration of 10(-9) M, which is much lower than the concentrations reportedly required to inhibit matrix synthesis.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	81-94
10443472-4	1999	Dexamethasone clearly blocked collagen degradation induced by the combination of interleukin-1 (IL-1) and plasminogen at the concentration of 10(-9) M, which is much lower than the concentrations reportedly required to inhibit matrix synthesis.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	96-100
10390188-3	1999	Ceramide, a product of sphingomyelin hydrolysis, is a known mediator of apoptotic effects of TNF, IL-1, and gammaIFN.	Ceramides	0-8	interleukin 1 alpha	Homo sapiens	98-102
10390188-3	1999	Ceramide, a product of sphingomyelin hydrolysis, is a known mediator of apoptotic effects of TNF, IL-1, and gammaIFN.	Sphingomyelins	23-36	interleukin 1 alpha	Homo sapiens	98-102
10441905-5	1999	The levels of IL-1 alpha and IL-6 mRNA induced by mineral fiber exposure were greatest in AMs exposed to TW, crocidolite, chrysotile and RF1 in that order.	Asbestos, Crocidolite	109-120	interleukin 1 alpha	Homo sapiens	14-24
10440637-12	1999	RESULTS: Estradiol at concentrations of 0.04 ng/ml or more significantly reduced both IL-1alpha and IL- 1beta production.	Estradiol	9-18	interleukin 1 alpha	Homo sapiens	86-95
10440637-15	1999	CONCLUSIONS: Estradiol and progesterone inhibited the production of IL-1 from human peripheral monocytes.	Estradiol	13-22	interleukin 1 alpha	Homo sapiens	68-72
10440637-15	1999	CONCLUSIONS: Estradiol and progesterone inhibited the production of IL-1 from human peripheral monocytes.	Progesterone	27-39	interleukin 1 alpha	Homo sapiens	68-72
10400419-8	1999	In contrast, PD98059, a specific inhibitor of the ERK pathway, counteracted the suppressive effects of SB203580 and IL-1 on the apoptotic process indicating that the protective effect of SB203580 and IL-1 might be the result of a shift in the balance between the ERK1/2 and p38/JNK route.	SB 203580	103-111	interleukin 1 alpha	Homo sapiens	200-204
10400419-8	1999	In contrast, PD98059, a specific inhibitor of the ERK pathway, counteracted the suppressive effects of SB203580 and IL-1 on the apoptotic process indicating that the protective effect of SB203580 and IL-1 might be the result of a shift in the balance between the ERK1/2 and p38/JNK route.	SB 203580	187-195	interleukin 1 alpha	Homo sapiens	116-120
10400419-10	1999	Finally, the IL-1 and SB203580-mediated effects were associated with an enhanced nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) binding activity, which could also be blocked by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	195-202	interleukin 1 alpha	Homo sapiens	13-17
10418175-8	1999	Ethanol can increase plasma endotoxin, a potent inducer of tumor necrosis factor (TNF)-alpha and IL-1.	Ethanol	0-7	interleukin 1 alpha	Homo sapiens	97-101
10403380-2	1999	When 293 cells prelabeled with 13H]AA were incubated with exogenous PUFAs in the presence of IL-1 and serum, there was a significant increase in [3H]AA release (in the order AA &gt; linoleic acid &gt; oleic acid), which was augmented markedly by sPLA2-IIA and modestly by type IV cytosolic PLA2 (cPLA2), but only minimally by type VI Ca2(+)-independent PLA2, overexpression.	Oleic Acid	185-195	interleukin 1 alpha	Homo sapiens	93-97
10403380-3	1999	Transfection of cPLA2 into sPLA2-IIA-expressing cells produced a synergistic increase in IL-1-dependent [3H]AA release and subsequent prostaglandin production.	Tritium	105-107	interleukin 1 alpha	Homo sapiens	89-93
10358197-3	1999	A selective inhibitor for p38 MAPK, SB203580, almost completely recovered the IL-1-induced growth inhibition in A375-C2-1 cells.	SB 203580	36-44	interleukin 1 alpha	Homo sapiens	78-82
10358197-4	1999	IL-1-induced IL-6 production was also suppressed by SB203580.	SB 203580	52-60	interleukin 1 alpha	Homo sapiens	0-4
10358197-7	1999	SB203580 also reversed the IL-1-induced down-regulation of ODC activity and intracellular polyamine levels without affecting ODC mRNA levels in A375-C2-1 cells.	SB 203580	0-8	interleukin 1 alpha	Homo sapiens	27-31
10358197-7	1999	SB203580 also reversed the IL-1-induced down-regulation of ODC activity and intracellular polyamine levels without affecting ODC mRNA levels in A375-C2-1 cells.	Polyamines	90-99	interleukin 1 alpha	Homo sapiens	27-31
10342828-5	1999	However, cotreatment of the cells with 17beta-E2 and increasing concentrations of either tumor necrosis factor-alpha (TNF alpha), interleukin-1alpha (IL-1alpha), or IL-1beta completely suppressed ERE-tk-luciferase activity in a dose-dependent manner (IC50 = 0.05-5.0 pM).	17beta-e2	39-48	interleukin 1 alpha	Homo sapiens	130-148
10342828-5	1999	However, cotreatment of the cells with 17beta-E2 and increasing concentrations of either tumor necrosis factor-alpha (TNF alpha), interleukin-1alpha (IL-1alpha), or IL-1beta completely suppressed ERE-tk-luciferase activity in a dose-dependent manner (IC50 = 0.05-5.0 pM).	17beta-e2	39-48	interleukin 1 alpha	Homo sapiens	150-159
10445612-4	1999	Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level.	SB 203580	74-83	interleukin 1 alpha	Homo sapiens	29-38
10445612-4	1999	Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level.	SB 203580	74-83	interleukin 1 alpha	Homo sapiens	109-118
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Inositol 1,4,5-Trisphosphate	202-230	interleukin 1 alpha	Homo sapiens	72-81
10367586-7	1999	These results suggest the existence of regulatory mechanisms of IL-1alpha-induced PGI2 production, which involve PGHS and PLA2 gene transcription.	Epoprostenol	82-86	interleukin 1 alpha	Homo sapiens	64-73
10380911-0	1999	Aspirin-induced increases in soluble IL-1 receptor type II concentrations in vitro and in vivo.	Aspirin	0-7	interleukin 1 alpha	Homo sapiens	37-41
10380911-8	1999	Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.	Aspirin	15-22	interleukin 1 alpha	Homo sapiens	117-121
10454832-0	1999	Interleukin-1 mediates hemodynamic dysfunction and release of eicosanoids and tumor necrosis factor during graded bacteremia.	Eicosanoids	62-73	interleukin 1 alpha	Homo sapiens	0-13
10454832-2	1999	The purpose of this study was to identify the circulatory derangements of which IL-1 was a necessary mediator and evaluate its interactions with tumor necrosis factor (TNF) and the eicosanoids during graded bacteremia.	Eicosanoids	181-192	interleukin 1 alpha	Homo sapiens	80-84
10454832-11	1999	Conversely, IL-1 helps to maintain stroke volume and low SVRI in graded bacteremia, possibly through increased prostacyclin release.	Epoprostenol	111-123	interleukin 1 alpha	Homo sapiens	12-16
10454832-14	1999	IL-1 is required for increased leukotriene and prostacyclin levels in this model, but it is not involved in thromboxane release.	Leukotrienes	31-42	interleukin 1 alpha	Homo sapiens	0-4
10454832-14	1999	IL-1 is required for increased leukotriene and prostacyclin levels in this model, but it is not involved in thromboxane release.	Epoprostenol	47-59	interleukin 1 alpha	Homo sapiens	0-4
10334936-9	1999	IL-1 alone slightly decreases the basal production of angiogenin protein and mRNA, but essentially abolishes the response to IL-6 in the absence or presence of dexamethasone.	Dexamethasone	160-173	interleukin 1 alpha	Homo sapiens	0-4
10384913-4	1999	In tape stripped skin, levels of prostaglandin E2 and interleukin-1alpha were increased 3.4-fold and 3.3-fold, respectively (p&lt;0.0001; p&lt;0.02), levels of tumour necrosis factor-alpha were decreased 3.0-fold (p&lt;0.01), whereas levels of interleukin-6 and leukotriene B4 in blister fluids remained relatively unchanged.	Leukotrienes	262-273	interleukin 1 alpha	Homo sapiens	54-72
10384913-6	1999	However, a correlation was observed between levels of prostaglandin E2 and interleukin-1alpha in capsaicin pre-treated blister fluids (r=0.58, p&lt;0.01, n=19).	Dinoprostone	54-70	interleukin 1 alpha	Homo sapiens	75-93
10384913-6	1999	However, a correlation was observed between levels of prostaglandin E2 and interleukin-1alpha in capsaicin pre-treated blister fluids (r=0.58, p&lt;0.01, n=19).	Capsaicin	97-106	interleukin 1 alpha	Homo sapiens	75-93
10385244-5	1999	MK-571 strongly enhanced IL-6 expression at mRNA and protein level in lipopolysaccharide (LPS) and interleukin-1 (IL-1) stimulated human monocytes giving rise to 2.0+/-0.4 (x+/-s.d.)	verlukast	0-6	interleukin 1 alpha	Homo sapiens	99-118
10385244-10	1999	MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059.	verlukast	0-6	interleukin 1 alpha	Homo sapiens	56-60
10385244-10	1999	MK-571 mediated upregulation of IL-6 in the presence of IL-1 was partially attenuated by SB203580 and PD98059.	SB 203580	89-97	interleukin 1 alpha	Homo sapiens	56-60
11096704-5	1999	Dexa- methasone inhibits synthesis of the inflammatory cytokines, interleukin-1 and tumor necrosis factor.	Dexamethasone	0-15	interleukin 1 alpha	Homo sapiens	66-105
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	interleukin 1 alpha	Homo sapiens	60-73
10815986-0	1999	Synthesis of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid.	N-Acetylneuraminic Acid	85-108	interleukin 1 alpha	Homo sapiens	32-50
10815986-1	1999	In order to develop glycosylated cytokine, recombinant human IL-1alpha was chemically modified with N-acetylneuraminic acid (NANA).	N-Acetylneuraminic Acid	100-123	interleukin 1 alpha	Homo sapiens	61-70
10815986-3	1999	Compound 6 was coupled to IL-1alpha by the acyl azide method.	acyl azide	43-53	interleukin 1 alpha	Homo sapiens	26-35
10815986-4	1999	The glycosylated IL-1 was purified by anion-exchange chromatography, and NANA coupled to IL-1 was confirmed by oxidation with NaIO4.	metaperiodate	126-131	interleukin 1 alpha	Homo sapiens	17-21
10815986-4	1999	The glycosylated IL-1 was purified by anion-exchange chromatography, and NANA coupled to IL-1 was confirmed by oxidation with NaIO4.	metaperiodate	126-131	interleukin 1 alpha	Homo sapiens	89-93
10815986-5	1999	Based on the molecular weight average number of carbohydrate molecules introduced per molecule of IL-1alpha was estimated to be 2.9.	Carbohydrates	48-60	interleukin 1 alpha	Homo sapiens	98-107
10453033-8	1999	These results suggest that alpha 2,6-linked sialic acids on a molecule(s) inducible by costimulation with IL-1 + IL-4 but not IL-1 alone down-regulates VCAM-1-dependent adhesion under flow conditions.	alpha 2,6-linked sialic acids	27-56	interleukin 1 alpha	Homo sapiens	106-110
10454570-3	1999	The results reveal that the EBS is required for the response to both inducers mediated by Ets-2, which is regulated at a level subsequent to DNA binding, by an IL-1- and phorbol ester-inducible transactivation domain.	ethylbenzene	28-31	interleukin 1 alpha	Homo sapiens	160-164
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	interleukin 1 alpha	Homo sapiens	237-241
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	interleukin 1 alpha	Homo sapiens	401-405
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	interleukin 1 alpha	Homo sapiens	237-241
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	interleukin 1 alpha	Homo sapiens	401-405
10471086-5	1999	Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.	tepoxalin	70-79	interleukin 1 alpha	Homo sapiens	222-226
10542977-5	1999	As it has been previously reported that IL-1 and TGF-beta stimulate prostaglandin E2 (PGE2) release from lung fibroblasts, we investigate here the role of endogenous PGE2 and the direct effects of the two inhibitors of prostaglandin synthesis, indomethacin and dexamethasone, on IL-11 production by human lung fibroblasts.	Dinoprostone	86-90	interleukin 1 alpha	Homo sapiens	40-44
10542977-5	1999	As it has been previously reported that IL-1 and TGF-beta stimulate prostaglandin E2 (PGE2) release from lung fibroblasts, we investigate here the role of endogenous PGE2 and the direct effects of the two inhibitors of prostaglandin synthesis, indomethacin and dexamethasone, on IL-11 production by human lung fibroblasts.	Prostaglandins	68-81	interleukin 1 alpha	Homo sapiens	40-44
10542977-10	1999	These results suggest that endogenous PGE2 acts as an autocrine stimulus for IL-11 production by human lung fibroblasts activated by IL-1 alpha and TGF-beta.	Dinoprostone	38-42	interleukin 1 alpha	Homo sapiens	133-143
10434040-10	1999	Both TNF-alpha and IL-1alpha stimulation of the endothelial cells resulted in an increase in the total incorporation of [(35)S]sulfate into macromolecules, which probably indicates an increase in the total production of proteoglycans.	Sulfates	127-134	interleukin 1 alpha	Homo sapiens	19-28
10476899-0	1999	Involvement of cyclooxygenase-2 in interleukin-1alpha-induced prostaglandin production by human periodontal ligament cells.	Prostaglandins	62-75	interleukin 1 alpha	Homo sapiens	35-53
10476899-3	1999	The purpose of the present study was to investigate the involvement of cyclooxygenase (COX)-1 and COX-2 in PGE2 production by PDL cells stimulated with a proinflammatory cytokine, interleukin-1alpha (IL-1alpha), and to examine the regulation of PGE2 production by cell-cell interaction of human gingival keratinocytes and PDL cells.	Dinoprostone	107-111	interleukin 1 alpha	Homo sapiens	180-198
10476899-3	1999	The purpose of the present study was to investigate the involvement of cyclooxygenase (COX)-1 and COX-2 in PGE2 production by PDL cells stimulated with a proinflammatory cytokine, interleukin-1alpha (IL-1alpha), and to examine the regulation of PGE2 production by cell-cell interaction of human gingival keratinocytes and PDL cells.	Dinoprostone	245-249	interleukin 1 alpha	Homo sapiens	180-198
10476899-4	1999	METHODS: The levels of PGE2 in the culture media of PDL cells stimulated with IL-1alpha or culture media of human gingival keratinocytes were determined by an enzyme-linked immunosorbent assay.	Dinoprostone	23-27	interleukin 1 alpha	Homo sapiens	78-87
10476899-6	1999	RESULTS: IL-1alpha-stimulated PDL cells produced PGE2 in a time-dependent manner.	Dinoprostone	49-53	interleukin 1 alpha	Homo sapiens	9-18
10476899-7	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by the IL-1alpha-stimulated cells.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	138-147
10476899-7	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by the IL-1alpha-stimulated cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	interleukin 1 alpha	Homo sapiens	138-147
10476899-7	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by the IL-1alpha-stimulated cells.	Dinoprostone	115-119	interleukin 1 alpha	Homo sapiens	138-147
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dexamethasone	49-62	interleukin 1 alpha	Homo sapiens	13-22
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dinoprostone	109-113	interleukin 1 alpha	Homo sapiens	13-22
10476899-13	1999	The PGE2 production was depressed by treatment of the cells with IL-1 receptor antagonist and anti- IL-1alpha antibody, not with anti-IL-1beta antibody.	Dinoprostone	4-8	interleukin 1 alpha	Homo sapiens	100-109
10476899-15	1999	CONCLUSIONS: We suggest that PDL cells stimulated with IL-1alpha produce PGE2 through de novo synthesis of COX-2 and that the cell interaction of gingival keratinocytes and PDL cells controls COX-2 expression and PGE2 production via IL-1alpha or 1alpha IL-la-like factor(s).	Dinoprostone	73-77	interleukin 1 alpha	Homo sapiens	55-64
10476899-15	1999	CONCLUSIONS: We suggest that PDL cells stimulated with IL-1alpha produce PGE2 through de novo synthesis of COX-2 and that the cell interaction of gingival keratinocytes and PDL cells controls COX-2 expression and PGE2 production via IL-1alpha or 1alpha IL-la-like factor(s).	Dinoprostone	213-217	interleukin 1 alpha	Homo sapiens	55-64
10518003-9	1999	These diarylheptanoids suppress phorbol ester-induced activation of ornithine decarboxylase and production of tumor necrosis factor-alpha or interleukin-1alpha and their mRNA expression.	Diarylheptanoids	6-22	interleukin 1 alpha	Homo sapiens	141-159
10518003-9	1999	These diarylheptanoids suppress phorbol ester-induced activation of ornithine decarboxylase and production of tumor necrosis factor-alpha or interleukin-1alpha and their mRNA expression.	Phorbol Esters	32-45	interleukin 1 alpha	Homo sapiens	141-159
10440637-3	1999	As PGE2 has been shown to suppress the production of IL-1 by monocytes, it was speculated that sex hormones also modify the production of IL-1 by regulating PGE2 production.	Dinoprostone	3-7	interleukin 1 alpha	Homo sapiens	53-57
10440637-3	1999	As PGE2 has been shown to suppress the production of IL-1 by monocytes, it was speculated that sex hormones also modify the production of IL-1 by regulating PGE2 production.	Dinoprostone	3-7	interleukin 1 alpha	Homo sapiens	138-142
10440637-3	1999	As PGE2 has been shown to suppress the production of IL-1 by monocytes, it was speculated that sex hormones also modify the production of IL-1 by regulating PGE2 production.	Dinoprostone	157-161	interleukin 1 alpha	Homo sapiens	138-142
10440637-11	1999	Indomethacin was used to inhibit the synthesis of PGE2 and eliminate its effect on the production of IL-1.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	101-105
10400419-8	1999	In contrast, PD98059, a specific inhibitor of the ERK pathway, counteracted the suppressive effects of SB203580 and IL-1 on the apoptotic process indicating that the protective effect of SB203580 and IL-1 might be the result of a shift in the balance between the ERK1/2 and p38/JNK route.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	interleukin 1 alpha	Homo sapiens	116-120
10400419-8	1999	In contrast, PD98059, a specific inhibitor of the ERK pathway, counteracted the suppressive effects of SB203580 and IL-1 on the apoptotic process indicating that the protective effect of SB203580 and IL-1 might be the result of a shift in the balance between the ERK1/2 and p38/JNK route.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	interleukin 1 alpha	Homo sapiens	200-204
10405161-2	1999	Hyaluronic acid with a molecular weight above 1.2 MDa (HMW-HA) inhibits the AGE-induced activation of the transcription factor NF-kappaB and the NF-kappaB-regulated cytokines interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	175-193
10403380-0	1999	Polyunsaturated fatty acids potentiate interleukin-1-stimulated arachidonic acid release by cells overexpressing type IIA secretory phospholipase A2.	Fatty Acids, Unsaturated	0-27	interleukin 1 alpha	Homo sapiens	39-52
10403380-0	1999	Polyunsaturated fatty acids potentiate interleukin-1-stimulated arachidonic acid release by cells overexpressing type IIA secretory phospholipase A2.	Arachidonic Acid	64-80	interleukin 1 alpha	Homo sapiens	39-52
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	142-169	interleukin 1 alpha	Homo sapiens	282-301
10403380-1	1999	By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells.	Fatty Acids, Unsaturated	171-176	interleukin 1 alpha	Homo sapiens	282-301
10403380-2	1999	When 293 cells prelabeled with 13H]AA were incubated with exogenous PUFAs in the presence of IL-1 and serum, there was a significant increase in [3H]AA release (in the order AA &gt; linoleic acid &gt; oleic acid), which was augmented markedly by sPLA2-IIA and modestly by type IV cytosolic PLA2 (cPLA2), but only minimally by type VI Ca2(+)-independent PLA2, overexpression.	13h	31-34	interleukin 1 alpha	Homo sapiens	93-97
10403380-2	1999	When 293 cells prelabeled with 13H]AA were incubated with exogenous PUFAs in the presence of IL-1 and serum, there was a significant increase in [3H]AA release (in the order AA &gt; linoleic acid &gt; oleic acid), which was augmented markedly by sPLA2-IIA and modestly by type IV cytosolic PLA2 (cPLA2), but only minimally by type VI Ca2(+)-independent PLA2, overexpression.	Tritium	32-34	interleukin 1 alpha	Homo sapiens	93-97
10403380-2	1999	When 293 cells prelabeled with 13H]AA were incubated with exogenous PUFAs in the presence of IL-1 and serum, there was a significant increase in [3H]AA release (in the order AA &gt; linoleic acid &gt; oleic acid), which was augmented markedly by sPLA2-IIA and modestly by type IV cytosolic PLA2 (cPLA2), but only minimally by type VI Ca2(+)-independent PLA2, overexpression.	Linoleic Acid	182-195	interleukin 1 alpha	Homo sapiens	93-97
10358077-2	1999	A combination of the pro-inflammatory cytokines interleukin (IL)-1alpha, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha induces nitric oxide synthase mRNA expression and nitric oxide (NO) generation in the human colon carcinoma cell line HT-29.	Nitric Oxide	143-155	interleukin 1 alpha	Homo sapiens	48-71
10364071-3	1999	Pretreatment of HUVECs with ethyl gallate (3 to 10 micromol/L) significantly suppressed interleukin-1alpha (IL-1alpha)- or tumor necrosis factor-alpha (TNF-alpha)- induced mRNA and cell-surface expression of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and E-selectin, which was associated with reduced adhesion of leukocytes to HUVECs.	ethyl gallate	28-41	interleukin 1 alpha	Homo sapiens	88-106
10364071-3	1999	Pretreatment of HUVECs with ethyl gallate (3 to 10 micromol/L) significantly suppressed interleukin-1alpha (IL-1alpha)- or tumor necrosis factor-alpha (TNF-alpha)- induced mRNA and cell-surface expression of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and E-selectin, which was associated with reduced adhesion of leukocytes to HUVECs.	ethyl gallate	28-41	interleukin 1 alpha	Homo sapiens	108-117
10407498-7	1999	IL-1 alpha, transforming growth factor-beta (TGF beta) and, to a lesser extent, tumor necrosis factor-alpha (TNF alpha) stimulated the IL-11 production by VSMC, and the stimulatory effects of IL-1 alpha and TGF beta on IL-11 production were dose-dependent.	vsmc	155-159	interleukin 1 alpha	Homo sapiens	0-10
10407498-8	1999	IL-1 alpha and TNF alpha synergistically augmented TGF beta-stimulated IL-11 production by VSMC.	vsmc	91-95	interleukin 1 alpha	Homo sapiens	0-10
10400830-2	1999	Genistein inhibited the 125I-labeled IL-1alpha binding to TIG-1 cells in both a time and dose dependent manner.	Genistein	0-9	interleukin 1 alpha	Homo sapiens	37-46
10400830-2	1999	Genistein inhibited the 125I-labeled IL-1alpha binding to TIG-1 cells in both a time and dose dependent manner.	Iodine-125	24-28	interleukin 1 alpha	Homo sapiens	37-46
10445612-4	1999	Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level.	SB 203580	229-238	interleukin 1 alpha	Homo sapiens	29-38
10445612-4	1999	Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level.	SB 203580	229-238	interleukin 1 alpha	Homo sapiens	109-118
10367586-0	1999	Interleukin-1alpha stimulated prostacyclin release by increasing gene transcription of prostaglandin H synthase and phospholipase A2 in human vascular endothelial cells.	Epoprostenol	30-42	interleukin 1 alpha	Homo sapiens	0-18
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Epoprostenol	86-98	interleukin 1 alpha	Homo sapiens	52-70
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Epoprostenol	86-98	interleukin 1 alpha	Homo sapiens	72-81
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Epoprostenol	100-104	interleukin 1 alpha	Homo sapiens	52-70
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Epoprostenol	100-104	interleukin 1 alpha	Homo sapiens	72-81
10367586-1	1999	This study was conducted to evaluate the effects of interleukin-1alpha (IL-1alpha) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca2+, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method.	Inositol 1,4,5-Trisphosphate	202-230	interleukin 1 alpha	Homo sapiens	52-70
10429944-11	1999	Dexamethasone, over a wide range of concentrations, markedly enhanced proteoglycan synthesis and completely reversed the downregulatory effects of IL-1 and IL-6 + sIL-6Ralpha.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	147-151
10334922-9	1999	Addition of NS-398 inhibited the expression of the ODF gene in osteoblast-like cells treated with BMP-2 and IL-1alpha.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	12-18	interleukin 1 alpha	Homo sapiens	108-117
10385262-6	1999	IL-1alpha-dependent receptor induction was blocked by cycloheximide.	Cycloheximide	54-67	interleukin 1 alpha	Homo sapiens	0-9
10385262-14	1999	Preincubation with IL-1alpha had a marked effect on prostanoid release in foreskin fibroblasts only.	Prostaglandins	52-62	interleukin 1 alpha	Homo sapiens	19-28
10385262-17	1999	The IL-1alpha induced rise in BK-stimulated PGE2 synthesis was fully abolished by specific inhibition of cyclo-oxygenase 2.	Dinoprostone	44-48	interleukin 1 alpha	Homo sapiens	4-13
10385262-19	1999	IL-1alpha sensitized BK-stimulated prostanoid synthesis and modulated prostanoid patterns differently in fibroblasts from skin and foreskin.	Prostaglandins	35-45	interleukin 1 alpha	Homo sapiens	0-9
10385262-19	1999	IL-1alpha sensitized BK-stimulated prostanoid synthesis and modulated prostanoid patterns differently in fibroblasts from skin and foreskin.	Prostaglandins	70-80	interleukin 1 alpha	Homo sapiens	0-9
10385262-20	1999	The IL-1alpha effects on prostanoid release were not related to BK receptor numbers nor to the BK-stimulated Ca2+ signal but appear to be due to induction of prostanoid synthesizing enzymes.	Prostaglandins	25-35	interleukin 1 alpha	Homo sapiens	4-13
10385262-20	1999	The IL-1alpha effects on prostanoid release were not related to BK receptor numbers nor to the BK-stimulated Ca2+ signal but appear to be due to induction of prostanoid synthesizing enzymes.	Prostaglandins	158-168	interleukin 1 alpha	Homo sapiens	4-13
10225968-6	1999	An antisense oligodeoxynucleotide complementary to IL-1alpha mRNA was used to suppress endogenous IL-1alpha.	Oligodeoxyribonucleotides	13-33	interleukin 1 alpha	Homo sapiens	51-60
10225968-6	1999	An antisense oligodeoxynucleotide complementary to IL-1alpha mRNA was used to suppress endogenous IL-1alpha.	Oligodeoxyribonucleotides	13-33	interleukin 1 alpha	Homo sapiens	98-107
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	interleukin 1 alpha	Homo sapiens	75-79
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	interleukin 1 alpha	Homo sapiens	63-67
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	interleukin 1 alpha	Homo sapiens	237-241
10231436-0	1999	Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells.	Arachidonic Acid	78-90	interleukin 1 alpha	Homo sapiens	0-13
10231436-8	1999	Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation.	Tritium	99-101	interleukin 1 alpha	Homo sapiens	83-87
10231436-4	1999	Free arachidonic acid (AA) activates several protein kinases, and because IL-1 rapidly stimulates phospholipase A2 (PLA2) activity release AA, IL-1-induced activation of JNK1/SAPK may be mediated by AA release.	Arachidonic Acid	5-21	interleukin 1 alpha	Homo sapiens	74-78
10231436-4	1999	Free arachidonic acid (AA) activates several protein kinases, and because IL-1 rapidly stimulates phospholipase A2 (PLA2) activity release AA, IL-1-induced activation of JNK1/SAPK may be mediated by AA release.	Arachidonic Acid	5-21	interleukin 1 alpha	Homo sapiens	143-147
10231436-7	1999	Using similar incubation conditions, IL-1 also increased [3H]AA release from MCs.	Tritium	58-60	interleukin 1 alpha	Homo sapiens	37-41
10231436-8	1999	Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation.	aristolochic acid I	25-42	interleukin 1 alpha	Homo sapiens	83-87
10231436-8	1999	Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation.	aristolochic acid I	25-42	interleukin 1 alpha	Homo sapiens	183-187
10329302-3	1999	Interleukin-1 (IL-1) plays an important role in the pathogenesis of osteoarthritis (OA) either directly or through the stimulation of catabolic factors, such as nitric oxide (NO).	Nitric Oxide	161-173	interleukin 1 alpha	Homo sapiens	0-13
10329302-3	1999	Interleukin-1 (IL-1) plays an important role in the pathogenesis of osteoarthritis (OA) either directly or through the stimulation of catabolic factors, such as nitric oxide (NO).	Nitric Oxide	161-173	interleukin 1 alpha	Homo sapiens	15-19
10102285-0	1999	Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid.	Dexamethasone	123-136	interleukin 1 alpha	Homo sapiens	43-61
10334506-2	1999	Esculetin (EST) significantly suppressed the proteoglycan depletion and the release of pulse-labeled [35S]proteoglycan from the matrix layer of rabbit chondrocytes treated with recombinant human interleukin-1alpha.	esculetin	0-9	interleukin 1 alpha	Homo sapiens	195-213
10334506-2	1999	Esculetin (EST) significantly suppressed the proteoglycan depletion and the release of pulse-labeled [35S]proteoglycan from the matrix layer of rabbit chondrocytes treated with recombinant human interleukin-1alpha.	Sulfur-35	102-105	interleukin 1 alpha	Homo sapiens	195-213
10203300-3	1999	A novel pre-assay treatment using Frigen II was introduced to improve the recovery rates of cytokines, i.e., interleukin-1alpha, interleukin-1beta and interleukin-1 receptor antagonist, prior to ELISA assay.	frigen ii	34-43	interleukin 1 alpha	Homo sapiens	109-127
10203300-3	1999	A novel pre-assay treatment using Frigen II was introduced to improve the recovery rates of cytokines, i.e., interleukin-1alpha, interleukin-1beta and interleukin-1 receptor antagonist, prior to ELISA assay.	frigen ii	34-43	interleukin 1 alpha	Homo sapiens	109-122
10102285-0	1999	Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid.	Tretinoin	142-155	interleukin 1 alpha	Homo sapiens	43-61
10092052-7	1999	IL-1alpha production was not modulated by FA or DEP even in the presence of PMA.	Tetradecanoylphorbol Acetate	76-79	interleukin 1 alpha	Homo sapiens	0-9
10408016-8	1999	These results suggest that both, IL-1 beta and IL-1 alpha, stimulate GAG and especially hyaluronic acid synthesis, but not DNA synthesis, in vitro.	Glycosaminoglycans	69-72	interleukin 1 alpha	Homo sapiens	47-57
10408016-8	1999	These results suggest that both, IL-1 beta and IL-1 alpha, stimulate GAG and especially hyaluronic acid synthesis, but not DNA synthesis, in vitro.	Hyaluronic Acid	88-103	interleukin 1 alpha	Homo sapiens	47-57
10217524-0	1999	Interleukin-1alpha and tumour necrosis factor-alpha modulate airway smooth muscle DNA synthesis by induction of cyclo-oxygenase-2: inhibition by dexamethasone and fluticasone propionate.	Dexamethasone	145-158	interleukin 1 alpha	Homo sapiens	0-18
10037734-4	1999	A 90-nucleotide sequence in the APP gene 5"-untranslated region (5"-UTR) conferred translational regulation by IL-1alpha and IL-1beta to a chloramphenicol acetyltransferase (CAT) reporter gene.	Chloramphenicol	139-154	interleukin 1 alpha	Homo sapiens	111-120
10037734-4	1999	A 90-nucleotide sequence in the APP gene 5"-untranslated region (5"-UTR) conferred translational regulation by IL-1alpha and IL-1beta to a chloramphenicol acetyltransferase (CAT) reporter gene.	Chloramphenicol	139-154	interleukin 1 alpha	Homo sapiens	125-133
10070049-11	1999	Finally, preincubating cells with pyrrolidinedithiocarbamate (PDTC) but not SN50 (inhibitors of nuclear factor-kappaB activation and nuclear translocation, respectively) attenuated increases in IGFBP-1 induced by IL-1.	pyrrolidine dithiocarbamic acid	34-60	interleukin 1 alpha	Homo sapiens	213-217
10217524-0	1999	Interleukin-1alpha and tumour necrosis factor-alpha modulate airway smooth muscle DNA synthesis by induction of cyclo-oxygenase-2: inhibition by dexamethasone and fluticasone propionate.	Fluticasone	163-185	interleukin 1 alpha	Homo sapiens	0-18
10217524-7	1999	The cytokine mixture, comprising IL-1alpha (0.01 and 0.1 pM) and TNF-alpha (3 and 30 pM), directly evoked increases in DNA synthesis which were attenuated by dexamethasone.	Dexamethasone	158-171	interleukin 1 alpha	Homo sapiens	33-42
9933650-6	1999	The oligosaccharides in fraction AR also inhibited the growth of an IL-1-dependent cell line, D10-G4.	Oligosaccharides	4-20	interleukin 1 alpha	Homo sapiens	68-72
10209072-2	1999	The authors previously showed negative regulation of IL-1alpha-induced prostaglandin (PG) production by corticotropin releasing factor (CRF).	Prostaglandins	71-84	interleukin 1 alpha	Homo sapiens	53-62
10209072-2	1999	The authors previously showed negative regulation of IL-1alpha-induced prostaglandin (PG) production by corticotropin releasing factor (CRF).	Prostaglandins	86-88	interleukin 1 alpha	Homo sapiens	53-62
10209072-4	1999	IL-1alpha (100 U/ml) increased prostacyclin (PGI2) (measured as 6-keto PGF1alpha[6K]) synthesis in endothelial cells and the production of PGE2in fibroblasts.	Epoprostenol	31-43	interleukin 1 alpha	Homo sapiens	0-9
10209072-4	1999	IL-1alpha (100 U/ml) increased prostacyclin (PGI2) (measured as 6-keto PGF1alpha[6K]) synthesis in endothelial cells and the production of PGE2in fibroblasts.	Epoprostenol	45-49	interleukin 1 alpha	Homo sapiens	0-9
10209072-4	1999	IL-1alpha (100 U/ml) increased prostacyclin (PGI2) (measured as 6-keto PGF1alpha[6K]) synthesis in endothelial cells and the production of PGE2in fibroblasts.	6-Ketoprostaglandin F1 alpha	64-80	interleukin 1 alpha	Homo sapiens	0-9
10209072-4	1999	IL-1alpha (100 U/ml) increased prostacyclin (PGI2) (measured as 6-keto PGF1alpha[6K]) synthesis in endothelial cells and the production of PGE2in fibroblasts.	Dinoprostone	139-143	interleukin 1 alpha	Homo sapiens	0-9
10209072-7	1999	IL- 1beta (100 U/ml) was as active as IL-1alpha in triggering release of PGI2 from endothelial cells and PGE2 from fibroblasts.	Epoprostenol	73-77	interleukin 1 alpha	Homo sapiens	38-47
10209072-7	1999	IL- 1beta (100 U/ml) was as active as IL-1alpha in triggering release of PGI2 from endothelial cells and PGE2 from fibroblasts.	Dinoprostone	105-109	interleukin 1 alpha	Homo sapiens	38-47
10074418-1	1999	Recent advances have provided evidence that prostaglandin E2 mediates the generation of fever in response to interleukin-1 or lipopolysaccharide and have reinforced the similarities of signaling downstream of these two pyrogens.	Dinoprostone	44-60	interleukin 1 alpha	Homo sapiens	109-122
10030389-8	1999	The LPS and IL-1 induced decrease in hepatic lipase could have several consequences including decreasing the clearance of triglyceride rich lipoprotein particles and producing an increase in triglyceride rich HDL.	Triglycerides	122-134	interleukin 1 alpha	Homo sapiens	12-16
10025919-3	1999	Purine-stimulated prostaglandin E2 (PGE2) release from chondrocytes, untreated or treated with recombinant human interleukin-1alpha (rHuIL-1alpha), was assessed by radioimmunoassay.	purine	0-6	interleukin 1 alpha	Homo sapiens	113-131
9931029-2	1999	Lateral mobility was measured by fluorescence photobleaching recovery, using a Cy3-modified, noncompetitive mAb specific for IL-1RI (M5) bound to wild-type IL-1 RI or mutant IL-1 RI with a truncated cytoplasmic tail.	cy3	79-82	interleukin 1 alpha	Homo sapiens	125-129
9931029-7	1999	Measurements of resistance to solubilization by Triton X-100 showed that IL-1 binding increases the fraction of IL-1 RI sedimenting with cytoskeletal residues.	Octoxynol	48-60	interleukin 1 alpha	Homo sapiens	73-77
9931029-7	1999	Measurements of resistance to solubilization by Triton X-100 showed that IL-1 binding increases the fraction of IL-1 RI sedimenting with cytoskeletal residues.	Octoxynol	48-60	interleukin 1 alpha	Homo sapiens	112-116
10025919-3	1999	Purine-stimulated prostaglandin E2 (PGE2) release from chondrocytes, untreated or treated with recombinant human interleukin-1alpha (rHuIL-1alpha), was assessed by radioimmunoassay.	Dinoprostone	36-40	interleukin 1 alpha	Homo sapiens	113-131
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	151-161
10100010-10	1999	Prostaglandin concentration was increased approximately 8-fold with IL-8 + IL-1 (P &lt; 0.0001) and 2.5-fold with IL-1 treatment (P &lt; 0.0001).	Prostaglandins	0-13	interleukin 1 alpha	Homo sapiens	75-79
10069413-3	1999	In this study, we examined the effect of one of the monovalent gold compounds, aurothioglucose (AuTG), on the IL-1-induced production of IL-6, IL-8 and granulocyte macrophage colony stimulating factor (GM-CSF) from rheumatoid synovial fibroblasts (RSF) isolated from three RA patients.	Aurothioglucose	79-94	interleukin 1 alpha	Homo sapiens	110-114
10211553-2	1999	Cisplatin has recently been shown to modulate interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha production in macrophages.	Cisplatin	0-9	interleukin 1 alpha	Homo sapiens	46-64
10100010-10	1999	Prostaglandin concentration was increased approximately 8-fold with IL-8 + IL-1 (P &lt; 0.0001) and 2.5-fold with IL-1 treatment (P &lt; 0.0001).	Prostaglandins	0-13	interleukin 1 alpha	Homo sapiens	114-118
10100010-12	1999	Our data suggest that IL-8 stimulates IL-1-induced uterine contractions through PGE2 production and could be an important process during labour and delivery.	Dinoprostone	80-84	interleukin 1 alpha	Homo sapiens	38-42
10221415-7	1999	For azithromycin, the most interesting results were for IL-1alpha (decrease in 100% of individuals) and for TNF-alpha (decrease in 100% of individuals).	Azithromycin	4-16	interleukin 1 alpha	Homo sapiens	56-65
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	230-240
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Ionomycin	108-117	interleukin 1 alpha	Homo sapiens	151-161
9880560-1	1999	Osteoblasts respond to stimulation with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) by production of nitric oxide and prostaglandins (PGs).	Nitric Oxide	153-165	interleukin 1 alpha	Homo sapiens	55-59
9880560-1	1999	Osteoblasts respond to stimulation with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) by production of nitric oxide and prostaglandins (PGs).	Prostaglandins	170-184	interleukin 1 alpha	Homo sapiens	55-59
9880560-3	1999	IL-1, TNF-alpha, IFN-gamma, and exogenous sodium nitroprusside, a nitric oxide donor, all stimulated PGE2 production in a dose-dependent manner.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	0-4
9880560-5	1999	However, IL-1-induced PGE2 was unaffected.	Dinoprostone	22-26	interleukin 1 alpha	Homo sapiens	9-13
10216981-7	1999	D9 Tetrahydrocannabinnol and their metabolites inhibit production of IL-1 and gamma interferon.	d9 tetrahydrocannabinnol	0-24	interleukin 1 alpha	Homo sapiens	69-73
11107311-2	1999	The release of IL-1alpha, IL-2 and TNF-alpha was suppressed up to 60-80% by 0,05 ng of the PCB.	Polychlorinated Biphenyls	91-94	interleukin 1 alpha	Homo sapiens	15-24
10470365-10	1999	This early event in the IL-1 signalling mechanisms confirms that D3 inositides, as well as canonical inositides produced by nuclear phospholipase C isoforms, are involved in this pathway of activation of transcription factors.	inositides	68-78	interleukin 1 alpha	Homo sapiens	24-28
10470365-10	1999	This early event in the IL-1 signalling mechanisms confirms that D3 inositides, as well as canonical inositides produced by nuclear phospholipase C isoforms, are involved in this pathway of activation of transcription factors.	inositides	101-111	interleukin 1 alpha	Homo sapiens	24-28
11107311-1	1999	Immunotoxic effects of PCB 77, PCB 126 could be demonstrated by evaluation of the production of interleukin IL-1alpha, IL-2 and the tumor necrosis factor (TNF-alpha) of stimulated human leukocytes.	Polychlorinated Biphenyls	23-26	interleukin 1 alpha	Homo sapiens	108-117
10721046-0	1999	Peripherally injected IL-1 induces anorexia and increases brain tryptophan concentrations.	Tryptophan	64-74	interleukin 1 alpha	Homo sapiens	22-26
10721046-3	1999	Here we present evidence showing that in an animal model the peripheral injection of interleukin-1 is followed by a significant rise in brain tryptophan concentrations.	Tryptophan	142-152	interleukin 1 alpha	Homo sapiens	85-98
10721046-5	1999	By inference, we conclude that interleukin-1 induced anorexia is mediated by at least two different mechanism: i) interleukin-1 direct action within the hypothalamus; ii) increased brain serotonergic activity, secondary to interleukin-1 induced increased brain availability of the serotonin precursor, tryptophan.	Serotonin	281-290	interleukin 1 alpha	Homo sapiens	31-44
10721046-5	1999	By inference, we conclude that interleukin-1 induced anorexia is mediated by at least two different mechanism: i) interleukin-1 direct action within the hypothalamus; ii) increased brain serotonergic activity, secondary to interleukin-1 induced increased brain availability of the serotonin precursor, tryptophan.	Tryptophan	302-312	interleukin 1 alpha	Homo sapiens	31-44
11107311-1	1999	Immunotoxic effects of PCB 77, PCB 126 could be demonstrated by evaluation of the production of interleukin IL-1alpha, IL-2 and the tumor necrosis factor (TNF-alpha) of stimulated human leukocytes.	Polychlorinated Biphenyls	31-34	interleukin 1 alpha	Homo sapiens	108-117
9888864-9	1999	Pretreatment of HepG2 cells with the protein kinase C inhibitor Ro 31-8220 or the mitogen-activated protein kinase kinase (MAPKK)1,2 activity blocker PD98059 selectively suppressed the induction of PAI-1 (and CAT) expression by PMA, but not that by IL-1alpha.	Ro 31-8220	64-74	interleukin 1 alpha	Homo sapiens	249-258
9888864-9	1999	Pretreatment of HepG2 cells with the protein kinase C inhibitor Ro 31-8220 or the mitogen-activated protein kinase kinase (MAPKK)1,2 activity blocker PD98059 selectively suppressed the induction of PAI-1 (and CAT) expression by PMA, but not that by IL-1alpha.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	150-157	interleukin 1 alpha	Homo sapiens	249-258
9888864-10	1999	In contrast, the protein tyrosine kinase inhibitor herbimycin A blocked PAI-1 mRNA induction by IL-1 alpha only.	herbimycin	51-63	interleukin 1 alpha	Homo sapiens	96-106
10221158-3	1999	Reactive oxygen species comprising lipid oxidation products have been implicated in the signaling pathways of both TNF alpha and IL-1 and accordingly could modulate atherogenic events.	Reactive Oxygen Species	0-23	interleukin 1 alpha	Homo sapiens	129-133
10221158-9	1999	13-HPODE administered simultaneously with IL-1 or TNF alpha induced ICAM-1 additively, suggesting that hydroperoxides and cytokines act on the same signaling pathways.	Hydrogen Peroxide	103-117	interleukin 1 alpha	Homo sapiens	42-46
9914865-6	1999	Studies in human vessels suggest that interleukin-1 is particularly important as a mediator of inflammatory dilatation; the underlying mechanisms include induction of the inducible isoform of nitric oxide synthase in vascular smooth muscle, or over-production of nitric oxide from the endothelial isoform of nitric oxide synthase.	Nitric Oxide	192-204	interleukin 1 alpha	Homo sapiens	38-51
10609879-3	1999	Preincubation of the murine T cell line EL-4 and the human umbilical cord vein endothelial cell line ECV 304 with thiol modifying compounds like diamide, menadione or phenylarsine oxide inhibited the IL-1-induced phosphorylation of an endogenous substrate with a molecular mass of 60 kD.	Sulfhydryl Compounds	114-119	interleukin 1 alpha	Homo sapiens	200-204
10609879-3	1999	Preincubation of the murine T cell line EL-4 and the human umbilical cord vein endothelial cell line ECV 304 with thiol modifying compounds like diamide, menadione or phenylarsine oxide inhibited the IL-1-induced phosphorylation of an endogenous substrate with a molecular mass of 60 kD.	Diamide	145-152	interleukin 1 alpha	Homo sapiens	200-204
10609879-3	1999	Preincubation of the murine T cell line EL-4 and the human umbilical cord vein endothelial cell line ECV 304 with thiol modifying compounds like diamide, menadione or phenylarsine oxide inhibited the IL-1-induced phosphorylation of an endogenous substrate with a molecular mass of 60 kD.	Vitamin K 3	154-163	interleukin 1 alpha	Homo sapiens	200-204
10609879-3	1999	Preincubation of the murine T cell line EL-4 and the human umbilical cord vein endothelial cell line ECV 304 with thiol modifying compounds like diamide, menadione or phenylarsine oxide inhibited the IL-1-induced phosphorylation of an endogenous substrate with a molecular mass of 60 kD.	oxophenylarsine	167-185	interleukin 1 alpha	Homo sapiens	200-204
10609879-4	1999	In the endothelial cell line, a second target of about 85 kD was phosphorylated after IL-1 stimulation, which was also inhibited by thiol modification.	Sulfhydryl Compounds	132-137	interleukin 1 alpha	Homo sapiens	86-90
10609879-5	1999	These data suggest that IL-1 signal transduction depends on free thiols which might be targets for redox regulation not only in lymphocytes, but also in endothelial cells.	Sulfhydryl Compounds	65-71	interleukin 1 alpha	Homo sapiens	24-28
9867839-2	1999	We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts.	2-(1H-imidazol-2-yl)pyridine	34-53	interleukin 1 alpha	Homo sapiens	95-108
10565988-7	1999	Gusperimus (deoxyspergualin), which inhibits IL-1 synthesis, was useful in reversing early and late acute rejection in clinical trials.	gusperimus	0-10	interleukin 1 alpha	Homo sapiens	45-49
10565988-7	1999	Gusperimus (deoxyspergualin), which inhibits IL-1 synthesis, was useful in reversing early and late acute rejection in clinical trials.	gusperimus	12-27	interleukin 1 alpha	Homo sapiens	45-49
10559659-4	1999	In contrast, inflammatory cytokines such as interleukin-1alpha may block or interfere with steroid-mediated MMP regulation at ectopic sites of growth.	Steroids	91-98	interleukin 1 alpha	Homo sapiens	44-62
9950270-3	1999	Pretreatment of HUVEC with PTX significantly antagonized TNF-, IL-1-, and G-CSF-activated transmigration of neutrophils.	Pentoxifylline	27-30	interleukin 1 alpha	Homo sapiens	63-67
9867839-2	1999	We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts.	SB 203580	54-63	interleukin 1 alpha	Homo sapiens	95-108
10325585-2	1999	Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha).	Ethanol	0-7	interleukin 1 alpha	Homo sapiens	176-185
10385482-5	1999	To solve this problem previously, we established an in vitro model that showed that cultured human mesangial cells (HMC) stimulated with interleukin-1 (IL-1) plus IL-6 can cause mesangial cell proliferation, increasing production of chemical mediators and superoxide anion.	Superoxides	256-272	interleukin 1 alpha	Homo sapiens	152-156
10364740-2	1999	METHODS: 125I-labeled IL-1alpha bound to lung fibroblasts in a specific and saturable manner in lung fibroblasts obtained from both IPF patients and control subjects.	Iodine-125	9-13	interleukin 1 alpha	Homo sapiens	22-31
10096130-1	1999	This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes.	Aflatoxin B1	39-51	interleukin 1 alpha	Homo sapiens	203-222
10096130-1	1999	This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes.	Aflatoxin B1	39-51	interleukin 1 alpha	Homo sapiens	224-234
10096130-1	1999	This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes.	Aflatoxin B1	53-57	interleukin 1 alpha	Homo sapiens	203-222
10096130-1	1999	This project focused on the effects of aflatoxin B1 (AFB1), a food-contaminating mycotoxin produced by fungi, genus Aspergillus, on the release and genetic expression of some important cytokines, i.e., (interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF alpha)) by human monocytes.	Aflatoxin B1	53-57	interleukin 1 alpha	Homo sapiens	224-234
10096130-4	1999	Pretreatment of monocytes with AFB1 resulted in a decrease in IL-1, IL-6 and TNF alpha release already at a concentration of 0.05 pg/mL.	Aflatoxin B1	31-35	interleukin 1 alpha	Homo sapiens	62-66
10096130-6	1999	In fact, AFB1 completely blocked the transcription of IL-1 alpha, IL-6 and TNF alpha mRNAs, while it did not affect beta-actin mRNA at the concentrations used.	Aflatoxin B1	9-13	interleukin 1 alpha	Homo sapiens	54-64
10325585-2	1999	Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha).	Ethanol	9-13	interleukin 1 alpha	Homo sapiens	176-185
10325585-9	1999	After 24 h of MTX exposure, the release of IL-1alpha was unchanged.	Methotrexate	14-17	interleukin 1 alpha	Homo sapiens	43-52
9828188-0	1998	Interleukin 1alpha stimulates lactate dehydrogenase A expression and lactate production in cultured porcine sertoli cells.	Lactic Acid	30-37	interleukin 1 alpha	Homo sapiens	0-18
9934491-2	1998	Truncated analogs of tripterine as cytokine (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8) release inhibitors are discussed.	celastrol	21-31	interleukin 1 alpha	Homo sapiens	45-55
9848873-0	1998	Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.	Sulfhydryl Compounds	106-111	interleukin 1 alpha	Homo sapiens	47-60
9848873-2	1998	Tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1 (IL-1)-induced E-selectin expression was analyzed after pretreating human umbilical vein endothelial cells with different thiol-modifying agents, ie, diamide, phenylarsine oxide, N-ethylmaleimide, and diethyl maleate.	oxophenylarsine	218-236	interleukin 1 alpha	Homo sapiens	45-64
9848873-2	1998	Tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1 (IL-1)-induced E-selectin expression was analyzed after pretreating human umbilical vein endothelial cells with different thiol-modifying agents, ie, diamide, phenylarsine oxide, N-ethylmaleimide, and diethyl maleate.	Ethylmaleimide	238-254	interleukin 1 alpha	Homo sapiens	45-64
9848873-2	1998	Tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1 (IL-1)-induced E-selectin expression was analyzed after pretreating human umbilical vein endothelial cells with different thiol-modifying agents, ie, diamide, phenylarsine oxide, N-ethylmaleimide, and diethyl maleate.	diethyl maleate	260-275	interleukin 1 alpha	Homo sapiens	45-64
9828188-1	1998	By using cultured porcine Sertoli cells as a model, the action of interleukin 1alpha (IL-1alpha) on lactate production and the site of this action were studied.	Lactic Acid	100-107	interleukin 1 alpha	Homo sapiens	66-84
9828188-1	1998	By using cultured porcine Sertoli cells as a model, the action of interleukin 1alpha (IL-1alpha) on lactate production and the site of this action were studied.	Lactic Acid	100-107	interleukin 1 alpha	Homo sapiens	86-95
9828188-2	1998	IL-1alpha stimulated Sertoli cell lactate production in a time- and dose-dependent manner (with a half-maximal effect [ED50] of 6 pM).	Lactic Acid	34-41	interleukin 1 alpha	Homo sapiens	0-9
9828188-4	1998	First, IL-1alpha was shown to increase the uptake of glucose substrate in a time- and dose-dependent manner.	Glucose	53-60	interleukin 1 alpha	Homo sapiens	7-16
9828188-6	1998	Second, IL-1alpha increased the activity of the lactate dehydrogenase (LDH) A4 isoform, which is involved in the conversion of pyruvate into lactate.	Pyruvic Acid	127-135	interleukin 1 alpha	Homo sapiens	8-17
9828188-6	1998	Second, IL-1alpha increased the activity of the lactate dehydrogenase (LDH) A4 isoform, which is involved in the conversion of pyruvate into lactate.	Lactic Acid	48-55	interleukin 1 alpha	Homo sapiens	8-17
9828188-9	1998	Assuming that IL-1alpha might be produced in the seminiferous tubules by both Sertoli and germ cells, which utilize lactate for their energy metabolism, we suggest that these results together show 1) that the cytokine may represent a signal in the metabolic cooperation existing between Sertoli cells and germ cells, and 2) that a redistribution of LDH isoforms in favor of LDH A4 under IL-1alpha control is a key mechanism(s) in such cooperation used by germ cells to enhance lactate production in Sertoli cells.	Lactic Acid	116-123	interleukin 1 alpha	Homo sapiens	14-23
9828188-9	1998	Assuming that IL-1alpha might be produced in the seminiferous tubules by both Sertoli and germ cells, which utilize lactate for their energy metabolism, we suggest that these results together show 1) that the cytokine may represent a signal in the metabolic cooperation existing between Sertoli cells and germ cells, and 2) that a redistribution of LDH isoforms in favor of LDH A4 under IL-1alpha control is a key mechanism(s) in such cooperation used by germ cells to enhance lactate production in Sertoli cells.	Lactic Acid	477-484	interleukin 1 alpha	Homo sapiens	14-23
9856766-8	1998	Histamine (100 microM) and interleukin-1alpha (IL-1alpha, 10 ng/ml) significantly stimulated IL-6 and granulocyte macrophage colony-stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells.	Histamine	164-173	interleukin 1 alpha	Homo sapiens	27-45
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	131-139	interleukin 1 alpha	Homo sapiens	0-9
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	250-258	interleukin 1 alpha	Homo sapiens	0-9
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	250-258	interleukin 1 alpha	Homo sapiens	74-83
9856766-8	1998	Histamine (100 microM) and interleukin-1alpha (IL-1alpha, 10 ng/ml) significantly stimulated IL-6 and granulocyte macrophage colony-stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells.	Histamine	164-173	interleukin 1 alpha	Homo sapiens	47-56
9834469-5	1998	IL-1alpha was less effective than IL-1beta at stimulating PGE2 production through similar mechanisms.	Dinoprostone	58-62	interleukin 1 alpha	Homo sapiens	0-9
10052722-0	1998	Nitric oxide suppresses bFGF- and IL-1-alpha-mediated but not VEGF165-mediated angiogenesis in natively vascularized mammalian tissue.	Nitric Oxide	0-12	interleukin 1 alpha	Homo sapiens	34-44
10052722-1	1998	Using the rat mesenteric window angiogenesis assay, we studied the systemic effect of the nitric oxide synthase inhibitor Nw-nitro-L-arginine methyl ester, L-NAME, on angiogenesis induced by basic fibroblast growth factor (bFGF), interleukin-1-alpha (IL-1) or vascular endothelial growth factor (VEGF165).	nw-nitro-l-arginine methyl ester	122-154	interleukin 1 alpha	Homo sapiens	251-255
10052722-7	1998	These data suggest that nitric oxide can act as an endogenous suppressor of mammalian de novo angiogenesis, which is a new finding, and, moreover, that angiogenesis induced by VEGF165 on the one hand and by bFGF and IL-1 on the other in the rat mesenteric window depends on different pathways.	Nitric Oxide	24-36	interleukin 1 alpha	Homo sapiens	216-220
9813140-4	1998	Pretreatment with nicotine caused a significant inhibition of LPS-induced IL-1, IL-8, and PGE2 expression at the transcriptional level in U937 cells.	Nicotine	18-26	interleukin 1 alpha	Homo sapiens	74-78
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Homo sapiens	5-14
9834469-9	1998	These results suggest that IL-1ra has partial agonist properties when used together with IL-1alpha and IL-1beta in fetal membranes by increasing cPLA2 protein levels, which leads to an increase in the production of prostaglandins.	Prostaglandins	215-229	interleukin 1 alpha	Homo sapiens	89-98
9849881-2	1998	SB 203580, an inhibitor of p38 MAPK, in the range 0.1-1 microM inhibited IL-1-stimulated PGE2 (but not arachidonic acid) release and this was associated with inhibition of induction of COX-2 protein and mRNA.	SB 203580	0-9	interleukin 1 alpha	Homo sapiens	73-77
9849881-2	1998	SB 203580, an inhibitor of p38 MAPK, in the range 0.1-1 microM inhibited IL-1-stimulated PGE2 (but not arachidonic acid) release and this was associated with inhibition of induction of COX-2 protein and mRNA.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	73-77
9811056-0	1998	Interleukin-1alpha and tumor necrosis factor alpha synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts.	Dinoprostone	77-93	interleukin 1 alpha	Homo sapiens	0-18
9811056-8	1998	The inhibition was prevented by PGE2, indicating that the synergistic effect of IL-1alpha and TNFalpha was PGE2-mediated.	Dinoprostone	32-36	interleukin 1 alpha	Homo sapiens	80-89
9811056-8	1998	The inhibition was prevented by PGE2, indicating that the synergistic effect of IL-1alpha and TNFalpha was PGE2-mediated.	Dinoprostone	107-111	interleukin 1 alpha	Homo sapiens	80-89
9811056-12	1998	CONCLUSION: These findings suggest that IL-1alpha and TNFalpha synergistically stimulate the production of IL-11 via their effects on PGE2 production in the rheumatoid joint, and that atypical PKC may be another target for down-regulation of IL-11, the bone resorption-associated cytokine.	Dinoprostone	134-138	interleukin 1 alpha	Homo sapiens	40-49
9821957-7	1998	We also show that the receptor is tyrosine phosphorylated in response to IL-1.	Tyrosine	34-42	interleukin 1 alpha	Homo sapiens	73-77
9846627-6	1998	IL-1alpha was a potent inducer of defensin gene expression in keratocytes, which began 12 h after challenge and peaked at 18 to 24 h. TNFalpha weakly induced defensin mRNA in keratocytes at about 18 h. Southern blots of the RT-PCR products probed with an oligonucleotide complementary to internal sequences of defensin demonstrated the appropriately sized products (198 bp) specific for defensin.	Oligonucleotides	255-270	interleukin 1 alpha	Homo sapiens	0-9
9795242-6	1998	IL-1alpha did, however, inhibit [35S]sulphate incorporation into xyloside-linked CS chains.	35s]sulphate	33-45	interleukin 1 alpha	Homo sapiens	0-9
11774448-0	1998	[1,25(OH)2 vitamin D3 induces IL-1 alpha mRNA expression from osteoblastic-like and bone marrow co-culture cells].	Calcitriol	1-21	interleukin 1 alpha	Homo sapiens	30-40
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Sulfur-35	108-111	interleukin 1 alpha	Homo sapiens	54-72
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Sulfur-35	108-111	interleukin 1 alpha	Homo sapiens	74-83
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Sulfates	112-120	interleukin 1 alpha	Homo sapiens	54-72
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Sulfates	112-120	interleukin 1 alpha	Homo sapiens	74-83
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Glycosaminoglycans	140-157	interleukin 1 alpha	Homo sapiens	54-72
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Glycosaminoglycans	140-157	interleukin 1 alpha	Homo sapiens	74-83
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Glycosaminoglycans	159-162	interleukin 1 alpha	Homo sapiens	54-72
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Glycosaminoglycans	159-162	interleukin 1 alpha	Homo sapiens	74-83
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Nitric Oxide	203-215	interleukin 1 alpha	Homo sapiens	54-72
9795242-1	1998	Incubation of human articular cartilage explants with interleukin-1alpha (IL-1alpha) inhibited the rate of [35S]sulphate incorporation into glycosaminoglycan (GAG) chains concomitant with an increase in nitric oxide (NO) production.	Nitric Oxide	203-215	interleukin 1 alpha	Homo sapiens	74-83
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Sulfur-35	20-23	interleukin 1 alpha	Homo sapiens	45-54
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Sulfates	24-32	interleukin 1 alpha	Homo sapiens	45-54
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Keratan Sulfate	87-103	interleukin 1 alpha	Homo sapiens	45-54
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Chondroitin Sulfates	108-128	interleukin 1 alpha	Homo sapiens	45-54
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Chondroitin Sulfates	130-132	interleukin 1 alpha	Homo sapiens	45-54
9765278-13	1998	In summary, inhibitors of either GC or PDE5 prevented IL-1 induction of iNOS; IL-1 increased the rates of both cGMP generation and hydrolysis; and exogenous PDE hydrolyzable cGMP analog induced iNOS and NO.	Cyclic GMP	111-115	interleukin 1 alpha	Homo sapiens	78-82
9765278-13	1998	In summary, inhibitors of either GC or PDE5 prevented IL-1 induction of iNOS; IL-1 increased the rates of both cGMP generation and hydrolysis; and exogenous PDE hydrolyzable cGMP analog induced iNOS and NO.	Cyclic GMP	174-178	interleukin 1 alpha	Homo sapiens	54-58
9765278-14	1998	These results suggest that increased cGMP metabolic flux is sufficient to induce iNOS, and GC and PDE5 activities are required for IL-1 induction of iNOS expression via increases in coupled cGMP synthesis and hydrolysis.	Cyclic GMP	190-194	interleukin 1 alpha	Homo sapiens	131-135
9778216-10	1998	Cell membrane-associated IL-1alpha and tumor necrosis factor a, but not CD69, CD40 ligand, or CD11b, were involved in the induction of MMP-1 and PGE2 production, as shown by blockade experiments using monoclonal antibodies and cytokine antagonists.	Dinoprostone	145-149	interleukin 1 alpha	Homo sapiens	25-34
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Cytochalasin D	72-74	interleukin 1 alpha	Homo sapiens	175-179
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Cytochalasin D	72-74	interleukin 1 alpha	Homo sapiens	253-257
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 alpha	Homo sapiens	175-179
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 alpha	Homo sapiens	253-257
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 alpha	Homo sapiens	175-179
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 alpha	Homo sapiens	253-257
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Homo sapiens	30-34
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Homo sapiens	84-88
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Cytochalasin D	41-43	interleukin 1 alpha	Homo sapiens	30-34
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Cytochalasin D	41-43	interleukin 1 alpha	Homo sapiens	84-88
9797556-0	1998	Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells.	Ceramides	0-8	interleukin 1 alpha	Homo sapiens	24-67
9704637-9	1998	Although IL-1-induced levels of PGE2 are reduced by IL-4, exogenous addition of PGE2 does not abrogate the inhibitory effects of IL-4 on MMP expression.	Dinoprostone	32-36	interleukin 1 alpha	Homo sapiens	9-13
9775393-7	1998	Moreover, the cortical laminar distribution of IL-1 alpha + microglia in control patients also correlated with the cortical laminar distribution of beta-APP+ neuritic plaques found in Alzheimer patients (r = 0.91, P < 0.05).	beta-app	148-156	interleukin 1 alpha	Homo sapiens	47-57
9661009-3	1998	Trovafloxacin levels achievable in humans suppressed in vitro synthesis of each of the cytokines analyzed, viz., interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha.	trovafloxacin	0-13	interleukin 1 alpha	Homo sapiens	113-132
9661009-3	1998	Trovafloxacin levels achievable in humans suppressed in vitro synthesis of each of the cytokines analyzed, viz., interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha.	trovafloxacin	0-13	interleukin 1 alpha	Homo sapiens	134-144
9671372-8	1998	Catecholamine secretion in response to IL-1 and IL-2 (50 and 500 units/well, respectively), or nicotinic agonist dimethylphenylpiperazinium (10 microM, which mimics the action of acetylcholine), was tested for comparison.	Catecholamines	0-13	interleukin 1 alpha	Homo sapiens	39-43
9645689-10	1998	These results demonstrate unequivocally that IL 1alpha and TNFalpha enhance human osteoclast formation and suggest that they mediate their effects through PGE2.	Dinoprostone	155-159	interleukin 1 alpha	Homo sapiens	45-54
9767420-2	1998	The results reported in the present study show that modulators of the renin-angiotensin system, such as the angiotensin-converting enzyme (ACE)-inhibitor captopril and the angiotensin II receptor type I antagonist valsartan, have potent inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines tumour necrosis factor (TNF) and interleukin-1 (IL-1) in vitro.	Captopril	154-163	interleukin 1 alpha	Homo sapiens	373-392
9661070-1	1998	Interleukin-1 (IL-1) is an important factor in bone metabolism, and its actions may be mediated in part via prostaglandins.	Prostaglandins	108-122	interleukin 1 alpha	Homo sapiens	0-13
9661070-1	1998	Interleukin-1 (IL-1) is an important factor in bone metabolism, and its actions may be mediated in part via prostaglandins.	Prostaglandins	108-122	interleukin 1 alpha	Homo sapiens	15-19
9738983-8	1998	Platinum compounds induced cytokine production in human EC: cisplatin most prominently induced the release of IL-1 and IL-6, and TRK-710 had the greatest ability to induce the release of GM-CSF.	Platinum	0-8	interleukin 1 alpha	Homo sapiens	110-114
9738983-8	1998	Platinum compounds induced cytokine production in human EC: cisplatin most prominently induced the release of IL-1 and IL-6, and TRK-710 had the greatest ability to induce the release of GM-CSF.	Cisplatin	60-69	interleukin 1 alpha	Homo sapiens	110-114
9738983-9	1998	Intracellular H2O2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H2O2 production was eliminated.	Hydrogen Peroxide	14-18	interleukin 1 alpha	Homo sapiens	136-140
9738983-9	1998	Intracellular H2O2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H2O2 production was eliminated.	Platinum	105-113	interleukin 1 alpha	Homo sapiens	136-140
9738983-9	1998	Intracellular H2O2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H2O2 production was eliminated.	Hydrogen Peroxide	154-158	interleukin 1 alpha	Homo sapiens	136-140
9684268-8	1998	Monounsaturated fatty acids and omega-3 polyunsaturated fatty acids (PUFAs) suppress TNF and IL-1 production and actions, while n-6 PUFAs exert the opposite effect.	Fatty Acids, Monounsaturated	0-27	interleukin 1 alpha	Homo sapiens	93-97
9684268-8	1998	Monounsaturated fatty acids and omega-3 polyunsaturated fatty acids (PUFAs) suppress TNF and IL-1 production and actions, while n-6 PUFAs exert the opposite effect.	omega-3 polyunsaturated fatty acids	32-67	interleukin 1 alpha	Homo sapiens	93-97
9684268-8	1998	Monounsaturated fatty acids and omega-3 polyunsaturated fatty acids (PUFAs) suppress TNF and IL-1 production and actions, while n-6 PUFAs exert the opposite effect.	Fatty Acids, Unsaturated	69-74	interleukin 1 alpha	Homo sapiens	93-97
9648943-4	1998	Northern analyses showed that IL-1-dependent collagenase mRNA production was significantly decreased in the presence of dexamethasone.	Dexamethasone	120-133	interleukin 1 alpha	Homo sapiens	30-34
9648943-8	1998	CAT transfection studies utilizing collagenase promoter demonstrated a dose-dependent transcriptional inhibition of IL-1-induced gingival collagenase gene expression by dexamethasone.	Dexamethasone	169-182	interleukin 1 alpha	Homo sapiens	116-120
11774448-5	1998	CONCLUSION: These results demonstrate that IL-1 alpha involves in osteoclast formation induced by 1,25(OH)2D3.	Calcitriol	98-109	interleukin 1 alpha	Homo sapiens	43-53
9765278-0	1998	Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.	Cyclic GMP	0-10	interleukin 1 alpha	Homo sapiens	63-76
9765278-0	1998	Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.	Cyclic GMP	15-19	interleukin 1 alpha	Homo sapiens	63-76
9765278-0	1998	Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.	Nitric Oxide	85-97	interleukin 1 alpha	Homo sapiens	63-76
9765278-2	1998	The GC inhibitors LY83583 and methylene blue dose-dependently inhibited IL-1-induced nitric oxide (NO) production, inducible NO synthase (iNOS) protein, and mRNA expression.	6-anilino-5,8-quinolinedione	18-25	interleukin 1 alpha	Homo sapiens	72-76
9765278-2	1998	The GC inhibitors LY83583 and methylene blue dose-dependently inhibited IL-1-induced nitric oxide (NO) production, inducible NO synthase (iNOS) protein, and mRNA expression.	Methylene Blue	30-44	interleukin 1 alpha	Homo sapiens	72-76
9765278-2	1998	The GC inhibitors LY83583 and methylene blue dose-dependently inhibited IL-1-induced nitric oxide (NO) production, inducible NO synthase (iNOS) protein, and mRNA expression.	Nitric Oxide	85-97	interleukin 1 alpha	Homo sapiens	72-76
9765278-3	1998	These effects of GC inhibition were consistent with the rapid induction of cGMP by IL-1, which reached maximal levels after 5 min.	Cyclic GMP	75-79	interleukin 1 alpha	Homo sapiens	83-87
9809805-5	1998	Here we show that CRF, through interaction with specific membrane receptors, blocks the interleukin-1alpha (IL-1alpha)-stimulated prostaglandin (PG) synthesis in fibroblasts.	Prostaglandins	130-143	interleukin 1 alpha	Homo sapiens	88-106
9809805-5	1998	Here we show that CRF, through interaction with specific membrane receptors, blocks the interleukin-1alpha (IL-1alpha)-stimulated prostaglandin (PG) synthesis in fibroblasts.	Prostaglandins	130-143	interleukin 1 alpha	Homo sapiens	108-117
9809805-5	1998	Here we show that CRF, through interaction with specific membrane receptors, blocks the interleukin-1alpha (IL-1alpha)-stimulated prostaglandin (PG) synthesis in fibroblasts.	Prostaglandins	145-147	interleukin 1 alpha	Homo sapiens	88-106
9809805-5	1998	Here we show that CRF, through interaction with specific membrane receptors, blocks the interleukin-1alpha (IL-1alpha)-stimulated prostaglandin (PG) synthesis in fibroblasts.	Prostaglandins	145-147	interleukin 1 alpha	Homo sapiens	108-117
9809805-9	1998	CRF blocked the effect of IL-1alpha on PGE2 synthesis, and this was antagonised by D-PheCRF12-41.	Dinoprostone	39-43	interleukin 1 alpha	Homo sapiens	26-35
9809805-10	1998	In addition, the CRF receptor antagonists alpha helical CRF9-41 and D-PheCRF12-41 at high concentrations inhibited the IL-1alpha-induced PG synthesis similarly to CRF, suggesting partial agonistic action.	Prostaglandins	137-139	interleukin 1 alpha	Homo sapiens	119-128
9876351-8	1998	IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake.	Thyrotropin	81-84	interleukin 1 alpha	Homo sapiens	0-10
9876351-8	1998	IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake.	Iodides	117-123	interleukin 1 alpha	Homo sapiens	0-10
9766505-5	1998	In CD34+ selected cells, preincubation with amifostine increased formation of CFU-GEMM up to 38-fold and produced macroscopic colonies, exceeding colony number in cultures initiated with optimal concentrations of interleukin-1 (IL-1), IL-3, or kit ligand (KL).	Amifostine	44-54	interleukin 1 alpha	Homo sapiens	228-232
9766505-6	1998	When compared with recombinant human cytokines, amifostine enhanced IL-1 and IL-3 induced colony formation, although its stimulatory effect was less than additive.	Amifostine	48-58	interleukin 1 alpha	Homo sapiens	68-72
10193524-6	1998	BB-3437, a selective inhibitor of stromelysin, neutrophil collagenase, and collagenase 3, at the concentrations used in this study, showed a weak but dose dependent inhibitory effect on the IL-1 stimulated degradation of type II collagen, but had virtually no effect on proteoglycan breakdown.	BB 3437	0-7	interleukin 1 alpha	Homo sapiens	190-194
9738019-0	1998	Serotonin-mediated production of interstitial collagenase by uterine smooth muscle cells requires interleukin-1alpha, but not interleukin-1beta.	Serotonin	0-9	interleukin 1 alpha	Homo sapiens	98-116
9738019-2	1998	Our previous studies investigating the mechanisms of this induction demonstrated that the mRNAs of both interleukin-1 (IL-1) isoforms, IL-1alpha and IL-1beta, are induced by serotonin and that the induction of IL-1 is required for the subsequent induction of collagenase.	Serotonin	174-183	interleukin 1 alpha	Homo sapiens	135-144
9738019-7	1998	Western analysis indicated that detectable levels of IL-1alpha protein, but not that of IL-1beta, are produced at the time of serotonin-dependent collagenase induction.	Serotonin	126-135	interleukin 1 alpha	Homo sapiens	53-62
9738019-9	1998	Taken together, the results of our study indicate that IL-1alpha, but not IL-1beta, plays an obligatory role in multiple serotonin-mediated gene regulations in the myometrial smooth muscle cell.	Serotonin	121-130	interleukin 1 alpha	Homo sapiens	55-64
9751081-2	1998	Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro.	Dinoprostone	132-148	interleukin 1 alpha	Homo sapiens	101-110
9751081-2	1998	Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro.	Dinoprostone	150-154	interleukin 1 alpha	Homo sapiens	101-110
9767285-9	1998	The production of IL-1 alpha/IL-6 was inhibited up to 80/89% (10-7-10-6 mol/L before and after irradiation) by dexamethasone in a concentration-dependent manner and with all conditions of incubation.	Dexamethasone	111-124	interleukin 1 alpha	Homo sapiens	18-28
9802549-6	1998	Cytokines, IL-1 and TNF enhanced the hydroxyl radical formation in phorbol 12-myristate 13-acetate treated chondrocytes.	Hydroxyl Radical	37-45	interleukin 1 alpha	Homo sapiens	11-23
9802549-6	1998	Cytokines, IL-1 and TNF enhanced the hydroxyl radical formation in phorbol 12-myristate 13-acetate treated chondrocytes.	Tetradecanoylphorbol Acetate	67-98	interleukin 1 alpha	Homo sapiens	11-23
9736250-0	1998	Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells.	Ceramides	18-26	interleukin 1 alpha	Homo sapiens	38-83
9687383-1	1998	We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells.	coumeromycin	17-29	interleukin 1 alpha	Homo sapiens	176-189
9687383-1	1998	We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells.	coumeromycin	17-29	interleukin 1 alpha	Homo sapiens	191-195
9687383-1	1998	We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells.	Novobiocin	41-51	interleukin 1 alpha	Homo sapiens	176-189
9687383-1	1998	We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells.	Novobiocin	41-51	interleukin 1 alpha	Homo sapiens	191-195
9714132-11	1998	IL-1 also increased the secretion of sphingolipids into the medium.	Sphingolipids	37-50	interleukin 1 alpha	Homo sapiens	0-4
9761378-3	1998	Pentoxifyllin (Ptx) regulates the production of several cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and, interferon gamma (IFN-gamma).	Pentoxifylline	0-13	interleukin 1 alpha	Homo sapiens	117-137
9761378-3	1998	Pentoxifyllin (Ptx) regulates the production of several cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and, interferon gamma (IFN-gamma).	Pentoxifylline	15-18	interleukin 1 alpha	Homo sapiens	117-137
9691088-6	1998	These results indicate that the inhibitory effects of TNF + LPS + IFN-gamma are mediated by nitric oxide, produced by the actions of IL-1 released endogenously within human islets.	Nitric Oxide	92-104	interleukin 1 alpha	Homo sapiens	133-137
9715184-20	1998	Perflubron exhibits an anti-inflammatory effect in the alveolar environment with reduction of proinflammatory IL-1 and IL-6 (possibly removing a stimulus for IL-10), white blood cell count, and protein capillary leak.	perflubron	0-10	interleukin 1 alpha	Homo sapiens	110-114
12799971-6	1998	RESULTS: Morphine and other opioids have immunomodulating effects on nearly all measurable parts of the immune system (macrophages, granulocytes, nk-cells; mediators like Interleukin 1, 2 and 6, TNF).	Morphine	9-17	interleukin 1 alpha	Homo sapiens	171-193
9703867-0	1998	Effect of interleukin-1 alpha and tumour necrosis factor-alpha on cisplatin-induced ERCC-1 mRNA expression in a human ovarian carcinoma cell line.	Cisplatin	66-75	interleukin 1 alpha	Homo sapiens	10-62
9703867-5	1998	The biological agents interleukin (IL)-1 alpha and tumour necrosis factor (TNF)-alpha have been shown to enhance cisplatin cytotoxicity in vitro.	Cisplatin	113-122	interleukin 1 alpha	Homo sapiens	22-46
9703867-6	1998	IL-1 alpha inhibited cisplatin induction of ERCC-1 mRNA levels in our system.	Cisplatin	21-30	interleukin 1 alpha	Homo sapiens	0-10
9697986-6	1998	Furthermore, we examined whether pirfenidone affects the cellular binding between cultured lymphocytes and IL-1alpha-stimulated synovial fibroblasts by in vitro binding assay and found their mutual binding was significantly suppressed in a dose-dependent manner by pirfenidone.	pirfenidone	33-44	interleukin 1 alpha	Homo sapiens	107-116
9697986-6	1998	Furthermore, we examined whether pirfenidone affects the cellular binding between cultured lymphocytes and IL-1alpha-stimulated synovial fibroblasts by in vitro binding assay and found their mutual binding was significantly suppressed in a dose-dependent manner by pirfenidone.	pirfenidone	265-276	interleukin 1 alpha	Homo sapiens	107-116
9649471-9	1998	RESULTS: After 24 hours of EtOH exposure, the release of IL-1 alpha doubled, that of IL-6 increased 10 times, and that of TNF-alpha increased 3.5 times.	Ethanol	27-31	interleukin 1 alpha	Homo sapiens	57-67
9661070-6	1998	IL-1 similarly induced PGHS-2 mRNA expression and PGE2 production in HOBIT and HOB cells.	Dinoprostone	50-54	interleukin 1 alpha	Homo sapiens	0-4
9661070-8	1998	Cycloheximide enhanced effects of both IL-1 and PMA, suggesting that de novo protein synthesis is not required for induction of PGHS-2.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	39-51
9661070-9	1998	Twenty-four hours of PMA pretreatment blocked the induction of PGHS-2 by PMA but not by IL-1, suggesting that IL-1 induction of PGHS-2 mRNA is not dependent on the protein kinase C pathway.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 alpha	Homo sapiens	110-114
9661070-10	1998	Although FSK alone had little effect, it enhanced induction of PGHS-2 mRNA by IL-1.	Colforsin	9-12	interleukin 1 alpha	Homo sapiens	78-82
9661070-12	1998	In summary, we show that IL-1 is a potent inducer of PGHS-2 expression and PGE2 production in human osteosarcoma cells as well as in osteoblastic cells derived from normal human bone.	Dinoprostone	75-79	interleukin 1 alpha	Homo sapiens	25-29
9667369-10	1998	IL 1 and IL 2 concentrations were suppressed in the cocaine-exposed fetal serum compared with controls (p &lt; 0.005 and p &lt; 0.05, respectively).	Cocaine	52-59	interleukin 1 alpha	Homo sapiens	0-4
9655393-6	1998	In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1-induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2.	Prostaglandins	151-164	interleukin 1 alpha	Homo sapiens	97-110
9795242-6	1998	IL-1alpha did, however, inhibit [35S]sulphate incorporation into xyloside-linked CS chains.	xylosides	65-73	interleukin 1 alpha	Homo sapiens	0-9
9795242-6	1998	IL-1alpha did, however, inhibit [35S]sulphate incorporation into xyloside-linked CS chains.	Chondroitin Sulfates	81-83	interleukin 1 alpha	Homo sapiens	0-9
9795242-8	1998	Disaccharide analysis of the [35S]GAG chains showed that IL-1alpha preferentially inhibited sulphation of the 6-sulphated isomer and that l-NIO reversed this effect.	Disaccharides	0-12	interleukin 1 alpha	Homo sapiens	57-66
9795242-8	1998	Disaccharide analysis of the [35S]GAG chains showed that IL-1alpha preferentially inhibited sulphation of the 6-sulphated isomer and that l-NIO reversed this effect.	Sulfur-35	30-33	interleukin 1 alpha	Homo sapiens	57-66
9795242-8	1998	Disaccharide analysis of the [35S]GAG chains showed that IL-1alpha preferentially inhibited sulphation of the 6-sulphated isomer and that l-NIO reversed this effect.	Glycosaminoglycans	34-37	interleukin 1 alpha	Homo sapiens	57-66
9795242-9	1998	Thus, IL-1alpha-induced NO mediates the inhibition of sulphate incorporation and alters the sulphation pattern of newly synthesised GAG chains.	Sulfates	54-62	interleukin 1 alpha	Homo sapiens	6-15
9795242-9	1998	Thus, IL-1alpha-induced NO mediates the inhibition of sulphate incorporation and alters the sulphation pattern of newly synthesised GAG chains.	Glycosaminoglycans	132-135	interleukin 1 alpha	Homo sapiens	6-15
9692192-2	1998	We show here that antimycin A, a respiratory inhibitor, induced interleukin-1 synthesis and tumoricidal activity without inducing tumor necrosis factor or nitric oxide.	Antimycin A	18-29	interleukin 1 alpha	Homo sapiens	64-77
9692192-5	1998	In contrast, lipopolysaccharide induced the production of interleukin-1, tumor necrosis factor and nitric oxide, the induction of tumoricidal activity being sensitive to genistein and brefeldin A.	Genistein	170-179	interleukin 1 alpha	Homo sapiens	58-94
9692192-5	1998	In contrast, lipopolysaccharide induced the production of interleukin-1, tumor necrosis factor and nitric oxide, the induction of tumoricidal activity being sensitive to genistein and brefeldin A.	Brefeldin A	184-195	interleukin 1 alpha	Homo sapiens	58-94
10200497-4	1998	IL-1 increases beta-cell formation of NO, ceramide, prostaglandins, heat-shock proteins, and activates a protease.	Ceramides	42-50	interleukin 1 alpha	Homo sapiens	0-4
10200497-4	1998	IL-1 increases beta-cell formation of NO, ceramide, prostaglandins, heat-shock proteins, and activates a protease.	Prostaglandins	52-66	interleukin 1 alpha	Homo sapiens	0-4
10200497-5	1998	Additionally, IL-1 depresses beta-cell energy production, insulin gene expression and cyclic AMP synthesis, and impacts negatively on different parts of the insulin stimulus-secretion coupling, actions mimicked by NO.	Cyclic AMP	86-96	interleukin 1 alpha	Homo sapiens	14-18
9629249-15	1998	IL-1 alpha-induced stimulation of prolactin release is also mediated by intrahypothalamic action of NO, which inhibits release of the prolactin-inhibiting hormone dopamine.	Dopamine	163-171	interleukin 1 alpha	Homo sapiens	0-10
9660250-0	1998	Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.	Serotonin	0-9	interleukin 1 alpha	Homo sapiens	87-96
9660250-0	1998	Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.	N-(p-coumaroyl)serotonin	22-47	interleukin 1 alpha	Homo sapiens	87-96
9660250-3	1998	CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity.	N-(p-coumaroyl)serotonin	0-2	interleukin 1 alpha	Homo sapiens	57-76
9660250-4	1998	ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS.	N-(p-coumaroyl)serotonin	102-104	interleukin 1 alpha	Homo sapiens	55-64
9602219-1	1998	Nickel, the allergen of contact dermatitis, induces the in vitro production of inflammation markers such as intracellular adhesion molecule-1, interleukin-1 and tumour necrosis factor-alpha by keratinocytes.	Nickel	0-6	interleukin 1 alpha	Homo sapiens	143-189
9648711-5	1998	The results showed that TNF-alpha, IL-1alpha, and PAF induced tyrosine phosphorylation of p38 MAP kinase in a dose- and time-dependent manner.	Tyrosine	62-70	interleukin 1 alpha	Homo sapiens	35-44
9648711-6	1998	The specific p38 MAP kinase inhibitor, SB 203580, completely inhibited TNF-alpha-, IL-1alpha-, or PAF-induced IL-8 protein and mRNA expression in BECs.	SB 203580	39-48	interleukin 1 alpha	Homo sapiens	83-92
9619668-6	1998	When the cells were treated with 100 ng/ml of interleukin-1alpha for 3 days, toluidine-blue-stained matrix was strikingly reduced.	Tolonium Chloride	77-91	interleukin 1 alpha	Homo sapiens	46-70
9564845-16	1998	Our results demonstrate that IGF-I and IL-1alpha synergistically increase the level of IGFBP-5 in OAC by inhibiting the proteolysis and stimulating the expression of IGFBP-5, respectively.	SDZ 33-243	98-101	interleukin 1 alpha	Homo sapiens	39-48
9564845-17	1998	Furthermore, the attenuation of IGF-I-stimulated proteoglycan synthesis by IL-1alpha in OAC appears to be mediated by chondrocyte IGFBPs.	SDZ 33-243	88-91	interleukin 1 alpha	Homo sapiens	75-84
9564848-5	1998	Treatment of LNCaP cells with IL-1alpha led to a dose-dependent inhibition of dihydrotestosterone (DHT) glucuronidation.	Dihydrotestosterone	78-97	interleukin 1 alpha	Homo sapiens	30-39
9564848-5	1998	Treatment of LNCaP cells with IL-1alpha led to a dose-dependent inhibition of dihydrotestosterone (DHT) glucuronidation.	Dihydrotestosterone	99-102	interleukin 1 alpha	Homo sapiens	30-39
9564848-6	1998	IL-1alpha decreased both UGT activity and LNCaP cell proliferation in the absence and presence of DHT (0.5 nM); a maximal inhibition of 70% was observed.	Dihydrotestosterone	98-101	interleukin 1 alpha	Homo sapiens	0-9
9881751-0	1998	Development of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with D-galactose monosaccharide: biological activities in vivo.	d-galactose monosaccharide	87-113	interleukin 1 alpha	Homo sapiens	34-52
9881751-1	1998	In our previous study, a galactose monosaccharide with C9 spacer was chemically coupled to recombinant human interleukin 1alpha (rhIL-1alpha) in order to study the effect of glycosylation on its activities, and to develop IL-1 with less deleterious effects.	galactose monosaccharide	25-49	interleukin 1 alpha	Homo sapiens	109-127
9881751-1	1998	In our previous study, a galactose monosaccharide with C9 spacer was chemically coupled to recombinant human interleukin 1alpha (rhIL-1alpha) in order to study the effect of glycosylation on its activities, and to develop IL-1 with less deleterious effects.	galactose monosaccharide	25-49	interleukin 1 alpha	Homo sapiens	131-135
10342749-10	1998	Anti-IL-1 autoantibody neutralized rhIL-1alpha in D10.G4 assay and inhibited receptor binding of FITC-rhIL-1alpha.	Fluorescein-5-isothiocyanate	97-101	interleukin 1 alpha	Homo sapiens	5-9
11774411-0	1998	[Influence of interleukin-1 and dexamethasone on prostaglandin production of condylar chondrocytes].	Prostaglandins	49-62	interleukin 1 alpha	Homo sapiens	14-45
11774411-1	1998	OBJECTIVE: To study the effect of recombinant human interleukin-1(rhIL-1) and dexamethasone on the amount of 6-keto-prostaglandin F1 alpha produced by condylar chondrocytes.	6-Ketoprostaglandin F1 alpha	109-138	interleukin 1 alpha	Homo sapiens	52-72
9719467-8	1998	Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves.	Nitric Oxide	150-162	interleukin 1 alpha	Homo sapiens	27-31
9719467-8	1998	Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves.	Peroxynitrous Acid	168-181	interleukin 1 alpha	Homo sapiens	27-31
9719467-8	1998	Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves.	oxygen free radicals	128-148	interleukin 1 alpha	Homo sapiens	27-31
9839700-3	1998	The aim now was to investigate interactive effects between interleukin 1 alpha, -beta (IL-1 alpha, -1 beta), tumour necrosis factor-alpha,-beta (TNF-alpha, -beta) and BK or thrombin on prostaglandin biosynthesis in human PDL cells.	Prostaglandins	185-198	interleukin 1 alpha	Homo sapiens	59-85
9839700-4	1998	IL-1 alpha and -1 beta produced time- and concentration-dependent stimulation of prostanoid biosynthesis [prostaglandin (PG)E2 and 6-keto-PGF1alpha].	Prostaglandins	81-91	interleukin 1 alpha	Homo sapiens	0-22
9839700-4	1998	IL-1 alpha and -1 beta produced time- and concentration-dependent stimulation of prostanoid biosynthesis [prostaglandin (PG)E2 and 6-keto-PGF1alpha].	Dinoprostone	106-126	interleukin 1 alpha	Homo sapiens	0-22
9839700-4	1998	IL-1 alpha and -1 beta produced time- and concentration-dependent stimulation of prostanoid biosynthesis [prostaglandin (PG)E2 and 6-keto-PGF1alpha].	6-Ketoprostaglandin F1 alpha	131-147	interleukin 1 alpha	Homo sapiens	0-22
9839700-11	1998	In addition, a synergistic effect on the PGE2 response to IL-1 alpha or -1 beta was demonstrated when added in combination with TNF-alpha.	Dinoprostone	41-45	interleukin 1 alpha	Homo sapiens	58-68
9839700-12	1998	These experiments demonstrate synergistic interactions between BK, thrombin, IL-1 and TNF on prostaglandin biosynthesis in cultured human PDL cells.	Prostaglandins	93-106	interleukin 1 alpha	Homo sapiens	77-89
9561912-10	1998	More significantly, they express constitutively the c-fms (the receptor of the macrophage growth factor) and, under TPA stimulation, are able to modulate the expression of this receptor and its ligand, as well as TNF-alpha and IL-1.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 alpha	Homo sapiens	227-231
9507015-0	1998	Requirements of focal adhesions and calcium fluxes for interleukin-1-induced ERK kinase activation and c-fos expression in fibroblasts.	Calcium	36-43	interleukin 1 alpha	Homo sapiens	55-68
9521089-3	1998	The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.	Steroids	30-38	interleukin 1 alpha	Homo sapiens	82-95
9521089-3	1998	The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.	Steroids	30-38	interleukin 1 alpha	Homo sapiens	97-101
9521089-3	1998	The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.	Steroids	30-37	interleukin 1 alpha	Homo sapiens	82-95
9521089-3	1998	The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections.	Steroids	30-37	interleukin 1 alpha	Homo sapiens	97-101
20654397-5	1998	Stimulation of interleukin-1alpha release from the A431 human keratinocyte cell line reflected in vivo erythema scores more closely than cytotoxic potential, and coincided with nitric oxide production by macrophages upon exposure to A431-conditioned medium.	Nitric Oxide	177-189	interleukin 1 alpha	Homo sapiens	15-33
9507015-9	1998	Calcium depletion abolished IL-1-induced calcium uptake, ERK activation, and c-fos expression.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	28-32
9507015-3	1998	Previous studies in our laboratory showed that IL-1-induced calcium flux is dependent on focal adhesion formation, suggesting a matrix-dependent restriction system for IL-1 signaling.	Calcium	60-67	interleukin 1 alpha	Homo sapiens	47-51
9507015-9	1998	Calcium depletion abolished IL-1-induced calcium uptake, ERK activation, and c-fos expression.	Calcium	41-48	interleukin 1 alpha	Homo sapiens	28-32
9507015-3	1998	Previous studies in our laboratory showed that IL-1-induced calcium flux is dependent on focal adhesion formation, suggesting a matrix-dependent restriction system for IL-1 signaling.	Calcium	60-67	interleukin 1 alpha	Homo sapiens	168-172
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	interleukin 1 alpha	Homo sapiens	33-37
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	interleukin 1 alpha	Homo sapiens	169-173
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Ionomycin	200-209	interleukin 1 alpha	Homo sapiens	33-37
9507015-6	1998	Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression.	Lysine	17-30	interleukin 1 alpha	Homo sapiens	78-82
9507015-6	1998	Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression.	Calcium	91-98	interleukin 1 alpha	Homo sapiens	78-82
9530111-2	1998	In this study, we show that activation of human umbilical vein endothelial cells (HUVEC) by IL-1 alpha leads to increased tyrosine phosphorylation of several proteins including one with a molecular mass of approximately 42 kDa.	Tyrosine	122-130	interleukin 1 alpha	Homo sapiens	92-102
9507015-11	1998	In transfection studies, IL-1 stimulation of serum responsive element (SRE) transcriptional activity was dependent on the presence of extracellular calcium.	Calcium	148-155	interleukin 1 alpha	Homo sapiens	25-29
9507015-13	1998	Our results demonstrate that in cells attached to substrates by focal adhesions, IL-1-mediated calcium flux is required for ERK activation and c-fos expression but not for JNK or p38 activation.	Calcium	95-102	interleukin 1 alpha	Homo sapiens	81-85
9534885-7	1998	Both IL-1 alpha and IL-1 beta showed a stronger growth-stimulatory activity on DF-derived fibroblasts in a dose-dependent manner than normal fibroblasts, and the percent 3H-TdR uptake of DF was 1.4-fold (IL-1 alpha; 1,000 U/ml) and 1.3-fold (IL-1 beta; 1,000 U/ml) as compared with normal fibroblasts; however, the differences did not reach any significance.	Tritium	170-172	interleukin 1 alpha	Homo sapiens	5-15
9530111-4	1998	Tyrosine phosphorylation and catalytic activation of p42mapk by IL-1 alpha was transient, reaching maximal levels after 30 min and returning to basal levels by 120-300 min.	Tyrosine	0-8	interleukin 1 alpha	Homo sapiens	64-74
9530111-8	1998	Genistein, but not Ro-31-8220, attenuated IL-1 alpha- and TNF-alpha-induced p42mapk activation.	Genistein	0-9	interleukin 1 alpha	Homo sapiens	42-52
9530111-9	1998	Taken together, the results of this study demonstrate 1) that p42mapk is transiently activated in HUVEC by IL-1 alpha and TNF-alpha, 2) that this activation is PKC independent, and 3) that a genistein-inhibitable tyrosine kinase may be an upstream regulator of cytokine-induced p42mapk activation in human endothelium.	Genistein	191-200	interleukin 1 alpha	Homo sapiens	107-117
9570453-2	1998	We investigated the in vitro effect of prostaglandin E1 on the synthesis of tumor necrosis factor-alpha, interleukin-1, interleukin-6, interleukin-10 and transforming growth factor beta by human peripheral blood mononuclear cells stimulated with lipopolysaccharides.	Alprostadil	39-55	interleukin 1 alpha	Homo sapiens	105-118
9692114-0	1998	N-acetylcysteine inhibits IL-1 alpha-induced IL-8 secretion by bronchial epithelial cells.	Acetylcysteine	0-16	interleukin 1 alpha	Homo sapiens	26-36
9452460-2	1998	We have demonstrated previously that microtubule depolymerization by colchicine in human monocytes induces selective production of interleukin-1 (IL-1) (Manie, S., Schmid-Alliana, A., Kubar, J., Ferrua, B., and Rossi, B.	Colchicine	69-79	interleukin 1 alpha	Homo sapiens	131-144
9452460-2	1998	We have demonstrated previously that microtubule depolymerization by colchicine in human monocytes induces selective production of interleukin-1 (IL-1) (Manie, S., Schmid-Alliana, A., Kubar, J., Ferrua, B., and Rossi, B.	Colchicine	69-79	interleukin 1 alpha	Homo sapiens	146-150
9452460-11	1998	The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556, a specific inhibitor of Src-like kinase, abrogates both the colchicine-induced ERK activation and IL-1 production.	Colchicine	54-64	interleukin 1 alpha	Homo sapiens	213-217
9452460-11	1998	The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556, a specific inhibitor of Src-like kinase, abrogates both the colchicine-induced ERK activation and IL-1 production.	cp 118556	104-113	interleukin 1 alpha	Homo sapiens	213-217
9480918-4	1998	Cells on fibronectin showed a 1.5-2-fold enhancement in IL-1-induced NF-kappaB activity compared with levels in cells on poly(l-lysine) or bare tissue culture plates.	poly(l-lysine	121-134	interleukin 1 alpha	Homo sapiens	56-60
9570473-3	1998	Oxatomide suppressed the production of interleukin-1alpha induced by Dermatophagoides farinae antigen in plastic-adherent cells.	oxatomide	0-9	interleukin 1 alpha	Homo sapiens	39-57
9613344-1	1998	OBJECTIVE: To determine whether antisense oligonucleotides targeting c-fos mRNA have the ability to inhibit the growth of interleukin 1 (IL1) stimulated fibroblast-like cells from the synovium in rheumatoid arthritis (RA).	Oligonucleotides	42-58	interleukin 1 alpha	Homo sapiens	122-135
9613344-1	1998	OBJECTIVE: To determine whether antisense oligonucleotides targeting c-fos mRNA have the ability to inhibit the growth of interleukin 1 (IL1) stimulated fibroblast-like cells from the synovium in rheumatoid arthritis (RA).	Oligonucleotides	42-58	interleukin 1 alpha	Homo sapiens	137-140
9613344-4	1998	RESULTS: C-fos antisense oligonucleotides inhibited IL1 stimulated synovial fibroblast proliferation.	Oligonucleotides	25-41	interleukin 1 alpha	Homo sapiens	52-55
9613344-5	1998	The expression of AP1 activity induced by IL1 was suppressed by treatment with antisense oligonucleotides.	Oligonucleotides	89-105	interleukin 1 alpha	Homo sapiens	42-45
9458352-0	1998	Role of p53 and apoptosis in sensitization of cis-diamminedichloroplatinum antitumor activity by interleukin-1 in ovarian carcinoma cells.	Cisplatin	46-74	interleukin 1 alpha	Homo sapiens	97-110
9485082-0	1998	ATP and UTP activate calcium-mobilizing P2U-like receptors and act synergistically with interleukin-1 to stimulate prostaglandin E2 release from human rheumatoid synovial cells.	Uridine Triphosphate	8-11	interleukin 1 alpha	Homo sapiens	88-101
9485082-0	1998	ATP and UTP activate calcium-mobilizing P2U-like receptors and act synergistically with interleukin-1 to stimulate prostaglandin E2 release from human rheumatoid synovial cells.	Dinoprostone	115-131	interleukin 1 alpha	Homo sapiens	88-101
9485082-4	1998	The effect of IL-1 prestimulation on purine-mediated PGE2 release was determined.	purine	37-43	interleukin 1 alpha	Homo sapiens	14-18
9485082-4	1998	The effect of IL-1 prestimulation on purine-mediated PGE2 release was determined.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	14-18
9485082-6	1998	ATP and UTP stimulated a small, but significant, increase in PG release from resting synoviocytes and a dramatic increase in PG release from synoviocytes prestimulated with recombinant human IL-1alpha.	Adenosine Triphosphate	0-3	interleukin 1 alpha	Homo sapiens	191-200
9485082-6	1998	ATP and UTP stimulated a small, but significant, increase in PG release from resting synoviocytes and a dramatic increase in PG release from synoviocytes prestimulated with recombinant human IL-1alpha.	Uridine Triphosphate	8-11	interleukin 1 alpha	Homo sapiens	191-200
9485082-6	1998	ATP and UTP stimulated a small, but significant, increase in PG release from resting synoviocytes and a dramatic increase in PG release from synoviocytes prestimulated with recombinant human IL-1alpha.	pg	125-127	interleukin 1 alpha	Homo sapiens	191-200
9485082-10	1998	P2U receptor agonists stimulate PGE2 release from synoviocytes, an effect that is greatly enhanced by IL-1alpha prestimulation and blocked by intracellular calcium buffering.	Dinoprostone	32-36	interleukin 1 alpha	Homo sapiens	102-111
9523245-0	1998	Interleukin 1 alpha hematological examination in mechanics exposed to low benzene concentrations.	Benzene	74-81	interleukin 1 alpha	Homo sapiens	0-19
9523245-1	1998	OBJECT: To examine the hypothesis of Renz and Kalf relative to the involvement of interleukin 1 alpha (IL-1 alpha) in the development of anemia in benzene-exposed workers.	Benzene	147-154	interleukin 1 alpha	Homo sapiens	82-101
9523245-1	1998	OBJECT: To examine the hypothesis of Renz and Kalf relative to the involvement of interleukin 1 alpha (IL-1 alpha) in the development of anemia in benzene-exposed workers.	Benzene	147-154	interleukin 1 alpha	Homo sapiens	103-113
9523245-2	1998	According to this hypothesis, benzene inhibits the cleavage of the IL-1 alpha precursor (proIL-1 alpha) to mature IL-1 alpha and the lack of this cytokine is responsible for benzene-induced bone marrow suppression.	Benzene	30-37	interleukin 1 alpha	Homo sapiens	67-77
9539008-6	1998	Model 1A is pesticide damage to the central nervous system, overlapping with body chemical burdens, TD, and chronic zinc deficiency; model 1B is benzene disruption of interleukin-1, overlapping with childhood developmental windows and hapten-antigenic spreading; and model 1C is autoimmunity to immunoglobulin-G (IgG), overlapping with spreading to other IgG-inducers, sudden spreading of inciters, and food-contaminating chemicals.	Benzene	145-152	interleukin 1 alpha	Homo sapiens	167-180
9458352-1	1998	We have previously reported that interleukin-1 (IL-1 ) sensitized cisplatin cytotoxicity against human ovarian NIH:OVCAR-3 tumor cells.	Cisplatin	66-75	interleukin 1 alpha	Homo sapiens	33-52
9523245-2	1998	According to this hypothesis, benzene inhibits the cleavage of the IL-1 alpha precursor (proIL-1 alpha) to mature IL-1 alpha and the lack of this cytokine is responsible for benzene-induced bone marrow suppression.	Benzene	30-37	interleukin 1 alpha	Homo sapiens	92-102
9523245-2	1998	According to this hypothesis, benzene inhibits the cleavage of the IL-1 alpha precursor (proIL-1 alpha) to mature IL-1 alpha and the lack of this cytokine is responsible for benzene-induced bone marrow suppression.	Benzene	174-181	interleukin 1 alpha	Homo sapiens	67-77
9458352-7	1998	The synergistic interactions of IL-1 with CDDP may involve the enhancement of p53-dependent apoptosis.	Cisplatin	42-46	interleukin 1 alpha	Homo sapiens	32-36
9570565-1	1998	During inflammatory joint diseases, chondrocytes are exposed to cytokines such as IL-1 that induce the synthesis of nitric oxide (NO).	Nitric Oxide	116-128	interleukin 1 alpha	Homo sapiens	82-86
9570533-2	1998	It is reported here that melatonin induces the secretion of IL-1, IL-6, and TNF in fresh and 1-day in vitro cultured monocytes that also express the melatonin receptor (Kd = 270 +/- 60 pM; 42,000-48,000 receptors/cell).	Melatonin	25-34	interleukin 1 alpha	Homo sapiens	60-64
9570565-6	1998	L-NMA completely reversed the suppression of proteoglycan synthesis imposed by IL-1 in deep chondrocytes, but produced only partial reversal in superficial cells.	l-nma	0-5	interleukin 1 alpha	Homo sapiens	79-83
9570565-8	1998	In the presence of L-NMA, however, IL-1 reduced the metabolic t(1/2) of proteoglycans by approximately 50% in both the superficial and deep zones.	l-nma	19-24	interleukin 1 alpha	Homo sapiens	35-39
9666258-3	1998	Chronic exposure to morphine appears to disrupt the brain-immune axis by desensitizing the IL-1 activation of the HPA axis, and consequently potentiate the LEA response to IL-1.	Morphine	20-28	interleukin 1 alpha	Homo sapiens	91-95
9607726-10	1998	Levels of the GR, c-fos and c-jun mRNAs were also significantly increased in the presence of IL1 and inhibited when DEX was co-incubated with IL1.	dex	116-119	interleukin 1 alpha	Homo sapiens	142-145
9493781-2	1998	CK 123 and CK 124 are new IL-1 blockers which showed potent anti-uveitis actions that are more potent than the classic corticosteroid, prednisolone.	Prednisolone	135-147	interleukin 1 alpha	Homo sapiens	26-30
9666258-3	1998	Chronic exposure to morphine appears to disrupt the brain-immune axis by desensitizing the IL-1 activation of the HPA axis, and consequently potentiate the LEA response to IL-1.	Morphine	20-28	interleukin 1 alpha	Homo sapiens	172-176
9437511-4	1998	The TC compounds that are highly effective against MMP-13 in vitro are also highly inhibitory of glycosaminoglycan release from interleukin-1-stimulated cartilage explants in culture.	Tetracycline	4-6	interleukin 1 alpha	Homo sapiens	128-141
9769026-8	1998	A strengthening of the cAMP-dependent signaling chains was found to counteract the proliferation rate, the formation of free oxygen radicals, and the stimulated release of TNF-alpha and IL-1beta in cultivated microglia.	Cyclic AMP	23-27	interleukin 1 alpha	Homo sapiens	186-194
9530957-0	1998	Development of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, by coupling with D-galactose monosaccharide: synthesis and purification.	d-galactose monosaccharide	91-117	interleukin 1 alpha	Homo sapiens	34-52
9530957-0	1998	Development of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, by coupling with D-galactose monosaccharide: synthesis and purification.	d-galactose monosaccharide	91-117	interleukin 1 alpha	Homo sapiens	63-72
9530957-1	1998	In order to develop glycosylated cytokine, recombinant human IL-1alpha was chemically modified with galactose monosaccharide.	galactose monosaccharide	100-124	interleukin 1 alpha	Homo sapiens	61-70
9530957-4	1998	Compound 3 was coupled to IL-1alpha by the acyl azide method.	acyl azide	43-53	interleukin 1 alpha	Homo sapiens	26-35
9530957-6	1998	Based on the molecular weight, the average number of carbohydrate molecules introduced per molecule of IL-1alpha was estimated to be 9.1.	Carbohydrates	53-65	interleukin 1 alpha	Homo sapiens	103-112
9530958-0	1998	Development of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, by coupling with D-galactose monosaccharide: biological activities in vitro.	d-galactose monosaccharide	91-117	interleukin 1 alpha	Homo sapiens	34-52
9530958-0	1998	Development of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, by coupling with D-galactose monosaccharide: biological activities in vitro.	d-galactose monosaccharide	91-117	interleukin 1 alpha	Homo sapiens	63-72
9530958-1	1998	In the previous study, galactose with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its activities, and to develop IL-1 with less deleterious effects.	Galactose	23-32	interleukin 1 alpha	Homo sapiens	97-106
9530958-1	1998	In the previous study, galactose with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its activities, and to develop IL-1 with less deleterious effects.	Galactose	23-32	interleukin 1 alpha	Homo sapiens	97-101
9530958-2	1998	In this study we examined a variety of IL-1 activities in vitro, including proliferative effect on T cells, antiproliferative effect on myeloid leukemic cells and melanoma cells, stimulatory effects on IL-6 synthesis by melanoma cells and PGE2 synthesis by fibroblast cells Galactose-introduced IL-1alpha (Gal-IL-1alpha) exhibited reduced activities from 10 to 10000 times compared with unmodified IL-1alpha in all the activities performed in vitro.	Dinoprostone	239-243	interleukin 1 alpha	Homo sapiens	39-43
9530958-2	1998	In this study we examined a variety of IL-1 activities in vitro, including proliferative effect on T cells, antiproliferative effect on myeloid leukemic cells and melanoma cells, stimulatory effects on IL-6 synthesis by melanoma cells and PGE2 synthesis by fibroblast cells Galactose-introduced IL-1alpha (Gal-IL-1alpha) exhibited reduced activities from 10 to 10000 times compared with unmodified IL-1alpha in all the activities performed in vitro.	Galactose	274-283	interleukin 1 alpha	Homo sapiens	39-43
9777883-1	1998	The aims of the present study were to determine whether beta2-agonists (short- and long-acting) and a glucocorticoid (budesonide) influence the secretion of a pro-inflammatory cytokine (interleukin-1, [IL-1]) and a granulocyte attractant (leukotriene B4 [LTB4]) and to compare these effects on blood monocyte and alveolar macrophages.	Budesonide	118-128	interleukin 1 alpha	Homo sapiens	186-207
9565081-1	1998	Slices of lapine meniscus produced large amounts of nitric oxide after stimulation with interleukin-1, tumor necrosis factor alpha, or a mixture of lapine synovial cytokines known as chondrocyte-activating factors.	Nitric Oxide	52-64	interleukin 1 alpha	Homo sapiens	88-130
9850935-7	1998	Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis.	Dinoprostone	13-17	interleukin 1 alpha	Homo sapiens	30-39
9565081-7	1998	Endogenously generated nitric oxide suppressed the synthesis of collagen and proteoglycan by menisci but protected proteoglycan from the catabolic effects of interleukin-1.	Nitric Oxide	23-35	interleukin 1 alpha	Homo sapiens	158-171
9565081-10	1998	Fragments of meniscus, but not meniscal cells in monolayer culture, increased their production of matrix metalloproteinases, lactate, and, especially, prostaglandin E2 in response to interleukin-1.	Lactic Acid	125-132	interleukin 1 alpha	Homo sapiens	183-196
9565081-10	1998	Fragments of meniscus, but not meniscal cells in monolayer culture, increased their production of matrix metalloproteinases, lactate, and, especially, prostaglandin E2 in response to interleukin-1.	Dinoprostone	151-167	interleukin 1 alpha	Homo sapiens	183-196
9634733-8	1998	It is proposed that high level of IL-1 production by blood lymphocytes may be used as a criterion in selection of DAT patients for amiridin therapy.	amiridine	131-139	interleukin 1 alpha	Homo sapiens	34-38
9836494-0	1998	The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation.	Prostaglandins	112-122	interleukin 1 alpha	Homo sapiens	76-89
9836494-3	1998	The aim of this study was to determine the prostanoids produced by lipopolysaccharide and interleukin-1 stimulated enterocytes through the cyclooxygenase-1 and 2 pathways.	Prostaglandins	43-54	interleukin 1 alpha	Homo sapiens	90-103
9493871-1	1998	A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.	TUFTSIN	214-229	interleukin 1 alpha	Homo sapiens	76-80
9493871-1	1998	A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.	TUFTSIN	214-229	interleukin 1 alpha	Homo sapiens	99-103
9493871-1	1998	A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.	TUFTSIN	214-229	interleukin 1 alpha	Homo sapiens	99-103
9493871-1	1998	A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.	TUFTSIN	214-229	interleukin 1 alpha	Homo sapiens	99-103
9476258-10	1998	IL-1 alpha synthesis was greatly suppressed by calcipotriol 10(-8)-10(-6) M. EGF at 10 ng/ml, in contrast, strongly stimulated IL-1 alpha production.	calcipotriene	47-59	interleukin 1 alpha	Homo sapiens	0-10
9496264-5	1997	Dexamethasone decreased the IL-1-stimulated IL-6 release in all cases.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	28-32
9704053-4	1997	IL-1-induced lung leak was decreased by treatment with superoxide dismutase (SOD), dimethylsulfoxide (DMSO), supercritical fluid-aerosolized vitamin E, interleukin-1-receptor antagonist (IL-1ra), or liposome-associated PGE1 (Lip-PGE1).	Dimethyl Sulfoxide	83-100	interleukin 1 alpha	Homo sapiens	0-4
9704053-4	1997	IL-1-induced lung leak was decreased by treatment with superoxide dismutase (SOD), dimethylsulfoxide (DMSO), supercritical fluid-aerosolized vitamin E, interleukin-1-receptor antagonist (IL-1ra), or liposome-associated PGE1 (Lip-PGE1).	Dimethyl Sulfoxide	102-106	interleukin 1 alpha	Homo sapiens	0-4
9704053-4	1997	IL-1-induced lung leak was decreased by treatment with superoxide dismutase (SOD), dimethylsulfoxide (DMSO), supercritical fluid-aerosolized vitamin E, interleukin-1-receptor antagonist (IL-1ra), or liposome-associated PGE1 (Lip-PGE1).	Vitamin E	141-150	interleukin 1 alpha	Homo sapiens	0-4
9704053-4	1997	IL-1-induced lung leak was decreased by treatment with superoxide dismutase (SOD), dimethylsulfoxide (DMSO), supercritical fluid-aerosolized vitamin E, interleukin-1-receptor antagonist (IL-1ra), or liposome-associated PGE1 (Lip-PGE1).	Alprostadil	219-223	interleukin 1 alpha	Homo sapiens	0-4
9360994-4	1997	Furthermore, two PI 3-kinase-specific inhibitors, wortmannin and a dominant-negative mutant of the p85 subunit, inhibited IL-1-induced activation of both NFkappaB and AP-1.	Wortmannin	50-60	interleukin 1 alpha	Homo sapiens	122-126
9367827-5	1997	Further experiments demonstrated that in THP-1 cells pretreated with PMA, Dex potently synergized with IL-1 to stimulate G-CSF production.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 alpha	Homo sapiens	103-107
9432636-6	1997	It was found that pentoxifylline (Ptx) was able to inhibit significantly the HLA-DR expression and glycosaminoglycan synthesis induced by inflammatory cytokines including TNF-alpha, IFN-gamma and IL-1.	Pentoxifylline	18-32	interleukin 1 alpha	Homo sapiens	196-200
9432636-6	1997	It was found that pentoxifylline (Ptx) was able to inhibit significantly the HLA-DR expression and glycosaminoglycan synthesis induced by inflammatory cytokines including TNF-alpha, IFN-gamma and IL-1.	Pentoxifylline	34-37	interleukin 1 alpha	Homo sapiens	196-200
9396157-5	1997	All the thiazolidines examined also inhibited IL-1 alpha-induced IL-6 production with IC50 values of 10 nM order.	Thiazolidines	8-21	interleukin 1 alpha	Homo sapiens	46-56
9359732-2	1997	CNI-1493 inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 production whether or not LPS stimulation was enhanced by interferon (IFN)-gamma priming.	semapimod	0-8	interleukin 1 alpha	Homo sapiens	87-110
9402031-6	1997	Treatment of HUVEC with THD in combination with LPS, TNF, and IL-1, respectively, antagonized LPS-activated transmigration of neutrophils but stimulated the effects of TNF and IL-1.	Thalidomide	24-27	interleukin 1 alpha	Homo sapiens	176-180
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	118-131
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	133-137
9368513-8	1997	In Graves" and multinodular goitre thyrocytes, inhibition of IL-1 (100 U/ml)-stimulated IL-6 release by dexamethasone (100 nmol/l) was 62.51% +/- 10.43 (S.E.M.	Dexamethasone	104-117	interleukin 1 alpha	Homo sapiens	61-65
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	163-167
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Dexamethasone	44-47	interleukin 1 alpha	Homo sapiens	118-131
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Dexamethasone	44-47	interleukin 1 alpha	Homo sapiens	133-137
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Dexamethasone	44-47	interleukin 1 alpha	Homo sapiens	163-167
9336410-8	1997	Studies of mRNA half-life showed that both NECA and forskolin decreased the half-life of collagenase mRNA in IL-1-stimulated FLS and HS68 cells.	Colforsin	52-61	interleukin 1 alpha	Homo sapiens	109-113
9325328-16	1997	Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation.	Iron	167-171	interleukin 1 alpha	Homo sapiens	39-52
9342951-7	1997	The products of Smith degradation (T2a-S) and lithium degradation (T2a-L) of T2a and the product of deacetylation (T2b-D) of T2b also induced monocytes to secret IL-1 as efficiently as the original polysaccharides, indicating that xylosyl and glucuronic acid residues as well as acetyl groups were not important to promote the cytokine-stimulating activity.	Lithium	46-53	interleukin 1 alpha	Homo sapiens	162-166
9283970-0	1997	Interactions of hydroxyapatite and fluorapatite particles on human osteoarthritis type B synoviocytes: effects on interleukin-1 alpha levels and lipoxygenase pathways.	Durapatite	16-30	interleukin 1 alpha	Homo sapiens	114-133
9283970-0	1997	Interactions of hydroxyapatite and fluorapatite particles on human osteoarthritis type B synoviocytes: effects on interleukin-1 alpha levels and lipoxygenase pathways.	fluorapatite	35-47	interleukin 1 alpha	Homo sapiens	114-133
9401927-4	1997	This IL-1 alpha, IL-1 beta, or TNF-alpha-induced IL-6 production was enhanced, but the cAMP accumulation they induced was inhibited by the addition of indomethacin.	Cyclic AMP	87-91	interleukin 1 alpha	Homo sapiens	5-15
9401927-4	1997	This IL-1 alpha, IL-1 beta, or TNF-alpha-induced IL-6 production was enhanced, but the cAMP accumulation they induced was inhibited by the addition of indomethacin.	Indomethacin	151-163	interleukin 1 alpha	Homo sapiens	5-15
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprostone	150-166	interleukin 1 alpha	Homo sapiens	52-71
9310253-5	1997	Results demonstrate that CEA-induced IL-1alpha and TNF-alpha production involves tyrosine phosphorylation and the signaling in CEA treated cells is different than that seen with LPS stimulation.	Tyrosine	81-89	interleukin 1 alpha	Homo sapiens	37-46
9278551-0	1997	Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1.	Prostaglandins	31-44	interleukin 1 alpha	Homo sapiens	141-154
9278551-5	1997	By contrast, systemic administration of the cyclooxygenase inhibitor indomethacin resulted in parallel dose-related attenuations of IL-1 effects in hypothalamus and medulla.	Indomethacin	69-81	interleukin 1 alpha	Homo sapiens	132-136
9278551-6	1997	Microinjections of prostaglandin E2 (PGE2; &gt;/=10 ng) in rostral ventrolateral medulla, the principal seat of IL-1-sensitive neurons that project to the PVH, provoked discrete patterns of cellular activation in hypothalamus and medulla that mimicked those seen in response to intravenous IL-1.	Dinoprostone	19-35	interleukin 1 alpha	Homo sapiens	112-116
9278551-6	1997	Microinjections of prostaglandin E2 (PGE2; &gt;/=10 ng) in rostral ventrolateral medulla, the principal seat of IL-1-sensitive neurons that project to the PVH, provoked discrete patterns of cellular activation in hypothalamus and medulla that mimicked those seen in response to intravenous IL-1.	Dinoprostone	19-35	interleukin 1 alpha	Homo sapiens	290-294
9278551-7	1997	We interpret these findings as supporting the hypothesis that paracrine effects of PGE2 released from perivascular cells in the medulla as a consequence of IL-1 stimulation and, acting through prostanoid receptors on or near local aminergic neurons that project to the PVH, contribute to the stimulatory effects of increased circulating IL-1 on neurons constituting the central limb of the hypothalamo-pituitary-adrenal axis.	Dinoprostone	83-87	interleukin 1 alpha	Homo sapiens	156-160
9278551-7	1997	We interpret these findings as supporting the hypothesis that paracrine effects of PGE2 released from perivascular cells in the medulla as a consequence of IL-1 stimulation and, acting through prostanoid receptors on or near local aminergic neurons that project to the PVH, contribute to the stimulatory effects of increased circulating IL-1 on neurons constituting the central limb of the hypothalamo-pituitary-adrenal axis.	Dinoprostone	83-87	interleukin 1 alpha	Homo sapiens	337-341
9299442-2	1997	To clarify the functional role of amniotic IL-1 alpha, we studied its effect on the induction of nitric oxide (NO) synthesis in the uterus.	Nitric Oxide	97-109	interleukin 1 alpha	Homo sapiens	43-53
9299442-4	1997	NO measurement by NO selective electrode revealed that NO production in the rat and human uterus treated with IL-1 alpha was promoted by the addition of 1 mM L-arginine to the culture medium.	Arginine	158-168	interleukin 1 alpha	Homo sapiens	110-120
9294212-6	1997	Ovarian steroids inhibit the release of IL-1alpha and repress MMP-1 production by IL-1alpha-stimulated fibroblasts.	Steroids	8-16	interleukin 1 alpha	Homo sapiens	40-49
9294212-6	1997	Ovarian steroids inhibit the release of IL-1alpha and repress MMP-1 production by IL-1alpha-stimulated fibroblasts.	Steroids	8-16	interleukin 1 alpha	Homo sapiens	82-91
9294212-9	1997	However, MMP-1 production in the human endometrium is ultimately blocked by ovarian steroids, which act both upstream and downstream of IL-1alpha, thereby exerting an effective control via a "double-block" mechanism.	Steroids	84-92	interleukin 1 alpha	Homo sapiens	136-145
9292697-2	1997	In zidovudine-induced myopathy and dermatomyositis, immunoreactivity for interleukin (IL)-1 has been reported in diseased muscle fibers involving myofibrillar breakdown and atrophy.	Zidovudine	3-13	interleukin 1 alpha	Homo sapiens	73-91
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprostone	150-166	interleukin 1 alpha	Homo sapiens	238-257
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprost	171-193	interleukin 1 alpha	Homo sapiens	52-71
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprost	171-193	interleukin 1 alpha	Homo sapiens	238-257
9322624-9	1997	Actinomycin D completely abolished interleukin-1 alpha-induced cyclooxygenase-2 messenger ribonucleic acid expression, suggesting that the cytokine caused transcriptional activation of the cyclooxygenase-2 gene.	Dactinomycin	0-13	interleukin 1 alpha	Homo sapiens	35-54
9376221-5	1997	These MAP kinase homologues are integral components of parallel MAP kinase cascades activated in response to a number of cellular stresses including inflammatory cytokines (e.g., Interleukin-1 (Il-1) and tumour necrosis factor-alpha (TNF-alpha), heat and chemical shock, bacterial endotoxin and ischaemia/cellular ATP depletion.	Adenosine Triphosphate	314-317	interleukin 1 alpha	Homo sapiens	179-198
9379324-1	1997	The formation of the biologically active metabolite 5 alpha-dihydrotestosterone (DHT) from testosterone in response to phenytoin (Ph), interleukin-1 (IL-1), and epidermal growth factor (EGF) was investigated.	Dihydrotestosterone	52-79	interleukin 1 alpha	Homo sapiens	135-154
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	95-105
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interleukin 1 alpha	Homo sapiens	95-105
9314353-9	1997	In vitro treatment with budesonide of SCF-producing fibroblasts demonstrated inhibition of unstimulated, primary Np fibroblasts but not of IL-1-stimulated fibroblasts or transformed cell lines.	Budesonide	24-34	interleukin 1 alpha	Homo sapiens	139-143
9276732-7	1997	Unlike results seen in other systems, the upregulation of Cox-2 and the subsequent release of eicosanoids by endothelial cells was not directly induced by complement but rather required production of IL-1alpha, which acted on endothelial cells as an autocrine factor.	Eicosanoids	94-105	interleukin 1 alpha	Homo sapiens	200-209
9379324-1	1997	The formation of the biologically active metabolite 5 alpha-dihydrotestosterone (DHT) from testosterone in response to phenytoin (Ph), interleukin-1 (IL-1), and epidermal growth factor (EGF) was investigated.	Dihydrotestosterone	81-84	interleukin 1 alpha	Homo sapiens	135-154
9379324-1	1997	The formation of the biologically active metabolite 5 alpha-dihydrotestosterone (DHT) from testosterone in response to phenytoin (Ph), interleukin-1 (IL-1), and epidermal growth factor (EGF) was investigated.	Testosterone	67-79	interleukin 1 alpha	Homo sapiens	135-154
9379324-6	1997	IL-1 stimulated DHT and 4-androstenedione synthesis by 2-fold (n = 6; P &lt; 0.01).	Dihydrotestosterone	16-19	interleukin 1 alpha	Homo sapiens	0-4
9379324-6	1997	IL-1 stimulated DHT and 4-androstenedione synthesis by 2-fold (n = 6; P &lt; 0.01).	Androstenedione	24-41	interleukin 1 alpha	Homo sapiens	0-4
9379324-9	1997	Combinations of Ph and IL-1 caused a 45% increase in the amount of DHT formed and a 66% increase in 4-androstenedione when compared to the effect of phenytoin alone (n = 3; P &lt; 0.01).	Dihydrotestosterone	67-70	interleukin 1 alpha	Homo sapiens	23-27
9379324-9	1997	Combinations of Ph and IL-1 caused a 45% increase in the amount of DHT formed and a 66% increase in 4-androstenedione when compared to the effect of phenytoin alone (n = 3; P &lt; 0.01).	Androstenedione	100-117	interleukin 1 alpha	Homo sapiens	23-27
9379324-12	1997	EGF and IL-1 present in inflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic pathway.	Phenytoin	70-79	interleukin 1 alpha	Homo sapiens	8-12
9379324-12	1997	EGF and IL-1 present in inflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic pathway.	Steroids	107-114	interleukin 1 alpha	Homo sapiens	8-12
9298933-0	1997	Interleukin-1alpha synergistic in vivo enhancement of cyclophosphamide- and carboplatin-mediated antitumor activity.	Cyclophosphamide	54-70	interleukin 1 alpha	Homo sapiens	0-18
9277444-7	1997	IFN-gamma (300 U/ml), TNF-alpha (20 ng/ml), and IL-1 alpha (20 ng/ml) all induced a significantly increased release of prelabeled [3H]AA after 15 min to 2 h of treatment in control cells, and their effects were significantly reduced in cells transfected with cPLA2 antisense vector.	Tritium	131-133	interleukin 1 alpha	Homo sapiens	48-58
9271402-6	1997	We identified a putative NLS in the G-kinase ATP binding domain which resembles the NLS of the interleukin-1alpha precursor.	Adenosine Triphosphate	45-48	interleukin 1 alpha	Homo sapiens	95-113
9280289-3	1997	Furthermore, generating singlet oxygen outside the cells by irradiation of rose bengal-coated resin particles with visible light (lambda &gt; 450 nm) results in the induction of interstitial collagenase, IL-1 and IL-6, similar to the response observed with UVA irradiation.	Singlet Oxygen	24-38	interleukin 1 alpha	Homo sapiens	204-208
9280289-3	1997	Furthermore, generating singlet oxygen outside the cells by irradiation of rose bengal-coated resin particles with visible light (lambda &gt; 450 nm) results in the induction of interstitial collagenase, IL-1 and IL-6, similar to the response observed with UVA irradiation.	Rose Bengal	75-86	interleukin 1 alpha	Homo sapiens	204-208
9280289-4	1997	These observations suggest that singlet oxygen is an early intermediate in the signaling pathway of IL-1 and IL-6 mediating UVA induction of interstitial collagenase (E.C.	Singlet Oxygen	32-46	interleukin 1 alpha	Homo sapiens	100-104
9298933-0	1997	Interleukin-1alpha synergistic in vivo enhancement of cyclophosphamide- and carboplatin-mediated antitumor activity.	Carboplatin	76-87	interleukin 1 alpha	Homo sapiens	0-18
9298933-2	1997	Studies were undertaken to examine the ability of IL-1alpha to enhance the activity of cyclophosphamide (CTX) administered in combination with carboplatin.	Cyclophosphamide	87-103	interleukin 1 alpha	Homo sapiens	50-59
9298933-6	1997	When carboplatin was added to the treatment schema, significantly greater clonogenic cell killing and tumor regrowth delay were observed as compared to any agent alone or a two-drug combination (CTX/IL-1alpha or CTX/carboplatin).	Carboplatin	5-16	interleukin 1 alpha	Homo sapiens	199-208
9298933-9	1997	These results demonstrate that IL-1alpha can synergistically enhance the antitumor efficacy of CTX and the combination of CTX and carboplatin.	Carboplatin	130-141	interleukin 1 alpha	Homo sapiens	31-40
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	47-57
9260920-5	1997	Newly transcribed BrU-labeled mRNA was recovered from the immunoprecipitates and analyzed by RT-PCR to study phorbol ester-mediated regulation of interleukin 1 gene transcription in human leukemic HL-60 or lymphoma U937 cells.	Phorbol Esters	109-122	interleukin 1 alpha	Homo sapiens	146-159
9293391-12	1997	PTX and BC reduced TPA-induced IL-1 alpha and beta expression.	Pentoxifylline	0-3	interleukin 1 alpha	Homo sapiens	31-41
9293391-12	1997	PTX and BC reduced TPA-induced IL-1 alpha and beta expression.	Tetradecanoylphorbol Acetate	19-22	interleukin 1 alpha	Homo sapiens	31-41
20654323-4	1997	The unsaturated fatty acids increased both TEWL and LDV and elevated IL-1alpha and IL-8 mRNA levels, whereas their effects on protein levels were minimal.	Fatty Acids, Unsaturated	4-27	interleukin 1 alpha	Homo sapiens	69-78
9254084-14	1997	It is therefore likely that fever, leukocytosis, and nitric oxide synthesis are also mediated by IL-1 in patients suffering from SAH and it is probable that the inflammatory mediators contribute to brain damage.	Nitric Oxide	53-65	interleukin 1 alpha	Homo sapiens	97-101
20654323-5	1997	In contrast, the saturated fatty acids were not very effective in vivo but induced an increase in IL-1alpha protein levels.	Fatty Acids	17-38	interleukin 1 alpha	Homo sapiens	98-107
9000541-4	1997	PTK inhibition with genistein or herbimycin A blocks LPSa-stimulated secretion of tumor necrosis factor (TNF) and interleukin-1 (IL-1).	Genistein	20-29	interleukin 1 alpha	Homo sapiens	114-134
9242341-0	1997	Unopposed interleukin-1 is necessary for increased plasma cytokine and eicosanoid levels to develop in severe sepsis.	Eicosanoids	71-81	interleukin 1 alpha	Homo sapiens	10-23
9242341-1	1997	OBJECTIVE: The purpose of the study was to identify the changes in plasma prostaglandin, leukotriene, and cytokine levels during clinical severe sepsis for which interleukin-1 was necessary.	Prostaglandins	74-87	interleukin 1 alpha	Homo sapiens	162-175
9242341-1	1997	OBJECTIVE: The purpose of the study was to identify the changes in plasma prostaglandin, leukotriene, and cytokine levels during clinical severe sepsis for which interleukin-1 was necessary.	Leukotrienes	89-100	interleukin 1 alpha	Homo sapiens	162-175
9242341-10	1997	The clinical significance of IL-1 in modifying circulating eicosanoid and cytokine concentrations in clinical sepsis is not clear from the data.	Eicosanoids	59-69	interleukin 1 alpha	Homo sapiens	29-33
9313345-3	1997	No concentration-related effect was found for IL-1-stimulated MeAIB uptake, and the IL-1-mediated MeAIB uptake stimulation is independent of protein synthesis.	2,2-dimethyl-beta-alanine	98-103	interleukin 1 alpha	Homo sapiens	84-88
9221826-10	1997	These findings indicate the rise in intracellular Ca2+ as the starting event and indicate the role of mitochondria as the source of second messenger molecules essential for TBT-induced NF-kappaB activation and IL-1alpha production.	tributyltin	173-176	interleukin 1 alpha	Homo sapiens	210-219
9169462-1	1997	Role of protein kinase C. Paclitaxel can induce tumor necrosis factor (TNF) and interleukin-1 gene expression, similar to lipopolysaccharides.	Paclitaxel	26-36	interleukin 1 alpha	Homo sapiens	80-93
9238541-0	1997	Effect of 5-fluorouracil on interleukin-1 and interleukin-2 receptor expression.	Fluorouracil	10-24	interleukin 1 alpha	Homo sapiens	28-41
9238541-1	1997	We have studied the effect of anticancer drug 5-fluorouracil on the expression of human Interleukin-1 and Interleukin-2 receptor.	Fluorouracil	46-60	interleukin 1 alpha	Homo sapiens	88-101
9238541-2	1997	In this report, we show that 5-Fluorouracil increases the Interleukin-1 expression upto 2.66 folds without significantly affecting the levels of surface expression of p55 IL-2 receptor on human Peripheral blood mononuclear cells, CD4 and CD8 T cells.	Fluorouracil	29-43	interleukin 1 alpha	Homo sapiens	58-71
9238541-5	1997	Taken together, 5-fluorouracil differentially affects the expression of Interleukin-1, Interferon-gamma and Interleukin-2 receptor.	Fluorouracil	16-30	interleukin 1 alpha	Homo sapiens	72-85
9262988-5	1997	Incubation with IL1+IL3+SCF caused an increase (fold expansion) in committed (28.6 +/- 8.1), immature (5.8 +/- 1.8), and primitive progenitors (4.1 +/- 0.8) among control CB MNC compared to a decrease in committed progenitors (0 +/- 0) but an increase in both immature (8.4 +/- 4.8) and primitive progenitors (7 +/- 2.9) among 5-FU resistant CB MNC.	Fluorouracil	327-331	interleukin 1 alpha	Homo sapiens	16-19
9143391-1	1997	Interleukin-1 alpha (IL-1 alpha) is myeloprotective in a variety of animal models of cancer chemotherapy and is similarly beneficial in adults treated with carboplatin, 5-fluorouracil, and after autologous bone marrow transplantation.	Carboplatin	156-167	interleukin 1 alpha	Homo sapiens	0-19
9143391-1	1997	Interleukin-1 alpha (IL-1 alpha) is myeloprotective in a variety of animal models of cancer chemotherapy and is similarly beneficial in adults treated with carboplatin, 5-fluorouracil, and after autologous bone marrow transplantation.	Carboplatin	156-167	interleukin 1 alpha	Homo sapiens	21-31
9143391-1	1997	Interleukin-1 alpha (IL-1 alpha) is myeloprotective in a variety of animal models of cancer chemotherapy and is similarly beneficial in adults treated with carboplatin, 5-fluorouracil, and after autologous bone marrow transplantation.	Fluorouracil	169-183	interleukin 1 alpha	Homo sapiens	0-19
9143391-1	1997	Interleukin-1 alpha (IL-1 alpha) is myeloprotective in a variety of animal models of cancer chemotherapy and is similarly beneficial in adults treated with carboplatin, 5-fluorouracil, and after autologous bone marrow transplantation.	Fluorouracil	169-183	interleukin 1 alpha	Homo sapiens	21-31
9256609-10	1997	Prednisolone inhibited the production of IL-1 alpha, IL-1 beta, IL-6 and TNF alpha.	Prednisolone	0-12	interleukin 1 alpha	Homo sapiens	41-51
9151701-5	1997	When spermine was added to cultures of human peripheral blood mononuclear cells stimulated with lipopolysaccharide (LPS), it effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, MIP-1alpha, and MIP-1beta.	Spermine	5-13	interleukin 1 alpha	Homo sapiens	223-236
9151701-5	1997	When spermine was added to cultures of human peripheral blood mononuclear cells stimulated with lipopolysaccharide (LPS), it effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, MIP-1alpha, and MIP-1beta.	Spermine	5-13	interleukin 1 alpha	Homo sapiens	238-242
9168952-5	1997	Similar inhibitory effects for DMF on VCAM-1 expression were observed after stimulation of HUVEC with LPS, PMA, IL-4, and IL-1 alpha or in combinations with TNF alpha.	Dimethyl Fumarate	31-34	interleukin 1 alpha	Homo sapiens	122-132
9154867-1	1997	We hypothesized that phospholipase A2 (PLA2) metabolites contribute to the acute, neutrophil-dependent, edematous lung leak that develops after administration of interleukin-1 (IL-1) intratracheally to rats and tested this premise by using mepacrine to inhibit PLA2 activity in vivo.	Quinacrine	240-249	interleukin 1 alpha	Homo sapiens	177-181
9154867-3	1997	By comparison, lungs of mecaprine and IL-1-treated rats had decreased PLA2 activity, lavage phospholipid content, leak, weight gain, and lavage protein increases compared with rats given IL-1 intratracheally.	Phospholipids	92-104	interleukin 1 alpha	Homo sapiens	38-42
9154867-4	1997	Mepacrine treatment also decreased lung neutrophil accumulation, but not lung lavage cytokine-induced neutrophil chemoattractant (CINC) levels, in rats given IL-1 intratracheally.	Quinacrine	0-9	interleukin 1 alpha	Homo sapiens	158-162
9154867-5	1997	In parallel experiments, mepacrine treatment reduced the adhesion of human neutrophils to IL-1-treated human umbilical vein endothelial cells in vitro.	Quinacrine	25-34	interleukin 1 alpha	Homo sapiens	90-94
9191309-0	1997	IL-1 gene expression in human mammary tumour xenografts after treatment with hexadecylphosphocholine.	miltefosine	77-100	interleukin 1 alpha	Homo sapiens	0-4
9159271-4	1997	Moreover, in laboratory animal species, IL-1, IL-6, and TNF-alpha have been found to modulate intermediary metabolism of carbohydrate, fat, and protein substrates, regulate hypothalamic-pituitary outflow, and act in the brain to reduce food intake.	Carbohydrates	121-133	interleukin 1 alpha	Homo sapiens	40-44
9175171-6	1997	In IL1 alpha treated cells, PGF2 alpha levels were 846 +/- 109 pg/ml (n = 9) (P &lt; 0.05, compared to basal levels) in the absence and 567 +/- 122 pg/ml (n = 9) in the presence of 100 microM SNP (P &lt; 0.05, compared to IL1 alpha alone).	Dinoprost	28-32	interleukin 1 alpha	Homo sapiens	3-12
9103457-2	1997	Upon in vitro and in vivo assay of IL-1 antagonism, the IL-1ra mutants DoB 0039 (N91--&gt;R), DoB 0040 (T109--&gt;A) and DoB 0041 (N91/T109--&gt;R/A) could inhibit IL-1beta effects more efficiently than wild-type IL-1ra, with DoB 0041 being the most active.	2,5-dimethoxy-4-bromoamphetamine	71-74	interleukin 1 alpha	Homo sapiens	35-39
9134225-13	1997	One of the following cytokines (epidermal growth factor, transforming growth factor alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8) was required for 1,25(OH)2D3 to suppress clonal growth and induce cell differentiation.	25(oh)2d3	181-190	interleukin 1 alpha	Homo sapiens	91-110
9119864-5	1997	In addition, TiAlV stimulated significantly more release of the other cell mediators, interleukin-1, tumour necrosis factor and interleukin-6.	tialv	13-18	interleukin 1 alpha	Homo sapiens	86-123
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 alpha	Homo sapiens	181-190
9147372-10	1997	The presence of 3,4,5-trimethoxybenzoic acid 8-(diethyl amino)-octyl ester (TMB-8), an inhibitor of intracellular calcium mobilization, as well as nickel chloride, a non-specific calcium channel blocker, in the media also inhibited A beta-induced IL-1 release from LPS-activated THP-1 cells.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	16-74	interleukin 1 alpha	Homo sapiens	247-251
9483201-14	1997	IL-1 alpha-induced stimulation of prolactin release is also mediated by intrahypothalamic action of NO which inhibits release of the prolactin-inhibiting hormone, dopamine.	Dopamine	163-171	interleukin 1 alpha	Homo sapiens	0-10
9029128-13	1997	Anti-IL-1alpha Ab or IL-1Ra only marginally reversed chloroquine-induced depression of proliferation for the low drug concentration, but not the massive cell death effect at and above 50 microM.	Chloroquine	53-64	interleukin 1 alpha	Homo sapiens	5-14
9029128-15	1997	The autocrine mechanism involving IL-1alpha accounts only for a minor fraction of the full antiendothelial effect of chloroquine, which is mainly dependent on apoptosis.	Chloroquine	117-128	interleukin 1 alpha	Homo sapiens	34-43
9067703-0	1997	Differences in responses of interleukin-1 and tumor necrosis factor alpha production and secretion to cyclosporin-A and ultraviolet B-irradiation by normal and transformed keratinocyte cultures.	Cyclosporine	102-115	interleukin 1 alpha	Homo sapiens	28-73
9547616-0	1997	IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids.	Linoleic Acid	67-80	interleukin 1 alpha	Homo sapiens	0-4
9561185-0	1997	Prostaglandin E2 production by endogenous secretion of interleukin-1 in decidual cells from term fetal membrane.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	55-68
9561191-0	1997	Stimulation of PG I2-synthesis in the periodontal tissue by interleukin-1 alpha and -1 beta.	Epoprostenol	15-20	interleukin 1 alpha	Homo sapiens	60-91
9138453-4	1997	RESULTS: Numerous studies indicate that TNF and IL-1 inhibit gonadotropin-stimulated steroidogenesis of undifferentiated ovarian cells due to inhibition of adenylyl cyclase and post-cAMP sites.	Cyclic AMP	182-186	interleukin 1 alpha	Homo sapiens	48-52
9202885-6	1997	Distinct regions of the proximal promoter respond to a wide array of signals such as phorbol myristate acetate (PMA) and Ca2+ ionophore or phytohemaglutinin (PHA), CD28 activation, human T leukemia virus (HTLV)-1 tax, TNF, and interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	112-115	interleukin 1 alpha	Homo sapiens	227-246
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Buthionine Sulfoximine	141-163	interleukin 1 alpha	Homo sapiens	0-19
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Iron	211-215	interleukin 1 alpha	Homo sapiens	0-19
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Deferoxamine	225-240	interleukin 1 alpha	Homo sapiens	0-19
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Deferoxamine	242-245	interleukin 1 alpha	Homo sapiens	0-19
8981044-5	1997	Interleukin-1 alpha and beta mRNA showed two peaks at 6 h and 72 h. The inhibition of catalase by aminotriazol (ATZ), inhibition of GSHPx by buthionine sulfoximine (BSO), and blocking the Fenton reaction by the iron chelator desferrioxamine (DFO) in concert led to an increase in steady-state MMP-1 mRNA levels, possibly dependent on intracellular H2O2 increase.	Hydrogen Peroxide	348-352	interleukin 1 alpha	Homo sapiens	0-19
9029220-0	1997	Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally.	lisofylline	0-11	interleukin 1 alpha	Homo sapiens	83-87
9029220-2	1997	In the present study, we found that rats pretreated intraperitoneally with lisofylline [(R)-1-(5-hydroxyhexyl)-3, 7-dimethylxanthine (LSF)], an inhibitor of lysophosphatidic acid acyl transferase, which reduces the production of unsaturated phosphatidic acid species, did not develop the lung leak or the related ultrastructural abnormalities that occur after intratracheal administration of IL-1.	lisofylline	75-86	interleukin 1 alpha	Homo sapiens	392-396
9029220-2	1997	In the present study, we found that rats pretreated intraperitoneally with lisofylline [(R)-1-(5-hydroxyhexyl)-3, 7-dimethylxanthine (LSF)], an inhibitor of lysophosphatidic acid acyl transferase, which reduces the production of unsaturated phosphatidic acid species, did not develop the lung leak or the related ultrastructural abnormalities that occur after intratracheal administration of IL-1.	lisofylline	134-137	interleukin 1 alpha	Homo sapiens	392-396
9029220-3	1997	However, rats pretreated with LSF and then given IL-1 intratracheally did develop the same elevations of lung lavage cytokine-induced neutrophil chemoattractant (CINC) levels and the same increased numbers of lung lavage neutrophils as rats given IL-1 intratracheally.	lisofylline	30-33	interleukin 1 alpha	Homo sapiens	49-53
9029220-3	1997	However, rats pretreated with LSF and then given IL-1 intratracheally did develop the same elevations of lung lavage cytokine-induced neutrophil chemoattractant (CINC) levels and the same increased numbers of lung lavage neutrophils as rats given IL-1 intratracheally.	lisofylline	30-33	interleukin 1 alpha	Homo sapiens	247-251
9029220-4	1997	Lungs of rats given IL-1 intratracheally also had increased unsaturated phosphatidic acid and free acyl (linoleate, linolenate) concentrations compared with untreated rats, and these lipid responses were prevented by pretreatment of LSF.	unsaturated phosphatidic acid	60-89	interleukin 1 alpha	Homo sapiens	20-24
9029220-4	1997	Lungs of rats given IL-1 intratracheally also had increased unsaturated phosphatidic acid and free acyl (linoleate, linolenate) concentrations compared with untreated rats, and these lipid responses were prevented by pretreatment of LSF.	acyl	99-103	interleukin 1 alpha	Homo sapiens	20-24
9029220-4	1997	Lungs of rats given IL-1 intratracheally also had increased unsaturated phosphatidic acid and free acyl (linoleate, linolenate) concentrations compared with untreated rats, and these lipid responses were prevented by pretreatment of LSF.	Linoleic Acid	105-114	interleukin 1 alpha	Homo sapiens	20-24
9029220-4	1997	Lungs of rats given IL-1 intratracheally also had increased unsaturated phosphatidic acid and free acyl (linoleate, linolenate) concentrations compared with untreated rats, and these lipid responses were prevented by pretreatment of LSF.	alpha-Linolenic Acid	116-126	interleukin 1 alpha	Homo sapiens	20-24
9029220-4	1997	Lungs of rats given IL-1 intratracheally also had increased unsaturated phosphatidic acid and free acyl (linoleate, linolenate) concentrations compared with untreated rats, and these lipid responses were prevented by pretreatment of LSF.	lisofylline	233-236	interleukin 1 alpha	Homo sapiens	20-24
8985205-2	1997	When PBMC were coincubated with activated autologous platelets amid lipopolysaccharide (LPS, 50-100 pg/mL) for 8 h, the production of interleukin (IL)-1alpha increased 11- to 18-fold and tumor necrosis factor (TNF)-alpha 3- to 5-fold compared with PBMC without platelets.	amid	63-67	interleukin 1 alpha	Homo sapiens	134-157
8985205-5	1997	These data suggest that platelet-PBMC interaction, both directly and with platelet-derived factors, enhances production of shock-producing IL-1alpha and TNF-alpha, albeit differently.	PBMC	33-37	interleukin 1 alpha	Homo sapiens	139-148
9218520-5	1997	A GST-IL-1R fusion protein containing the entire cd (amino acids 369-569; GST-IL-1Rcd) recruited a kinase activity in the absence and presence of IL-1 stimulation.	Cadmium	49-51	interleukin 1 alpha	Homo sapiens	6-10
9263277-7	1997	The synthesis of interleukin-2 by lymphocytes and of interleukin-1 by macrophages is glutamine-dependent.	Glutamine	85-94	interleukin 1 alpha	Homo sapiens	53-66
9185523-7	1997	IL-1 increased the intensity of staining of alveolar type II cells for SP-B, and the concentrations of SP-B, -A, and disaturated phosphatidylcholine in bronchoalveolar lavage.	lecithins, disaturated	117-148	interleukin 1 alpha	Homo sapiens	0-4
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	adenosine cyclic 3",5"-phosphorothioate	22-61	interleukin 1 alpha	Homo sapiens	145-149
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	77-80	interleukin 1 alpha	Homo sapiens	145-149
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	Staurosporine	13-26	interleukin 1 alpha	Homo sapiens	75-79
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	calphostin C	31-43	interleukin 1 alpha	Homo sapiens	75-79
9169347-8	1997	Pretreatment of cells with 17 beta-estradiol (17 beta-E2) antagonized IL-1-stimulated IL-6 production.	Estradiol	27-44	interleukin 1 alpha	Homo sapiens	70-74
9169347-8	1997	Pretreatment of cells with 17 beta-estradiol (17 beta-E2) antagonized IL-1-stimulated IL-6 production.	17 beta-e2	46-56	interleukin 1 alpha	Homo sapiens	70-74
9140562-11	1997	Exposure to IGF and steroids prevented the decrease in mitogenesis that could lead to cellular loss, particularly in IL-1-conditioned explants.	Steroids	20-28	interleukin 1 alpha	Homo sapiens	117-121
9216708-7	1997	In the 5"-DFUR + OK-432 group, the level of IL-1 alpha production in tumor was significantly higher compared to the control group.	doxifluridine	7-14	interleukin 1 alpha	Homo sapiens	44-54
9152234-9	1997	When actinomycin D was added to stimulated keratocytes to inhibit transcription, the half-life of GRO alpha mRNA in TNF-alpha-treated cells was &lt; 1 hour, whereas the half-life of the GRO alpha mRNA synthesized in IL-1 alpha-stimulated cells was &gt; or = 9 hours.	Dactinomycin	5-18	interleukin 1 alpha	Homo sapiens	216-226
9151802-6	1997	The ability of IL-1 to upregulate Glut1 and Glut3 transcripts proved time-, dose-, nitric oxide-, and protein biosynthesis-dependent but glucose independent.	Nitric Oxide	83-95	interleukin 1 alpha	Homo sapiens	15-19
9151802-6	1997	The ability of IL-1 to upregulate Glut1 and Glut3 transcripts proved time-, dose-, nitric oxide-, and protein biosynthesis-dependent but glucose independent.	Glucose	137-144	interleukin 1 alpha	Homo sapiens	15-19
9160101-1	1997	Pentoxifylline and the two analogues HWA138 and HWA448, at concentrations exceeding 60 micrograms/ml, inhibited malaria antigen or lipopolysaccharide (LPS) induced TNF-alpha and IL-1 alpha secretion, but not IL-6 secretion, from human peripheral blood mononuclear cells in vitro.	Pentoxifylline	0-14	interleukin 1 alpha	Homo sapiens	178-188
9108098-6	1997	GPI-associated diacylglycerols independently activate the calcium-independent epsilon isoform of protein kinase C. Both signals collaborate in regulating the downstream NF-kappa B/rel-dependent gene expression of interleukin 1alpha, tumor necrosis factor (TNF) alpha, and inducible NO synthase.	Diglycerides	15-30	interleukin 1 alpha	Homo sapiens	213-231
9108098-6	1997	GPI-associated diacylglycerols independently activate the calcium-independent epsilon isoform of protein kinase C. Both signals collaborate in regulating the downstream NF-kappa B/rel-dependent gene expression of interleukin 1alpha, tumor necrosis factor (TNF) alpha, and inducible NO synthase.	Calcium	58-65	interleukin 1 alpha	Homo sapiens	213-231
9176105-8	1997	AcLDL stimulated IL-8 secretion &gt; TNF-alpha &gt; IL-1 alpha &gt; IL-2 = IFN-gamma = IL-1 beta, and decreased GM-CSF secretion eightfold.	acldl	0-5	interleukin 1 alpha	Homo sapiens	52-62
9105426-3	1997	Pre-treatment of HUVEC for 30 min with protein tyrosine kinase (PTK) inhibitors genistein and herbimycin A (10 micrograms/ml and 0.5 microgram/ml, respectively) before stimulation with IL-1 did not affect the expression of these molecules.	herbimycin	94-106	interleukin 1 alpha	Homo sapiens	185-189
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	PBMC	25-29	interleukin 1 alpha	Homo sapiens	149-159
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	Sodium Chloride	91-95	interleukin 1 alpha	Homo sapiens	149-159
9065752-5	1997	Tyrphostin-47, which as an inhibitor of protein-tyrosine kinases abolished vanadate-induced protein-tyrosine phosphorylation, inhibited expression of the two COX isoenzyme mRNAs in HUVEC stimulated with vanadate or interleukin-1alpha.	tyrphostin 47	0-13	interleukin 1 alpha	Homo sapiens	215-233
9065752-5	1997	Tyrphostin-47, which as an inhibitor of protein-tyrosine kinases abolished vanadate-induced protein-tyrosine phosphorylation, inhibited expression of the two COX isoenzyme mRNAs in HUVEC stimulated with vanadate or interleukin-1alpha.	Vanadates	75-83	interleukin 1 alpha	Homo sapiens	215-233
9065752-5	1997	Tyrphostin-47, which as an inhibitor of protein-tyrosine kinases abolished vanadate-induced protein-tyrosine phosphorylation, inhibited expression of the two COX isoenzyme mRNAs in HUVEC stimulated with vanadate or interleukin-1alpha.	Tyrosine	48-56	interleukin 1 alpha	Homo sapiens	215-233
9126706-5	1997	Incubation of mesangial cells with the oxidizing agents diamide or hydrogen peroxide did not upregulate MCP-1 gene expression, and prevented IL-1 induction of MCP-1 mRNA.	Hydrogen Peroxide	67-84	interleukin 1 alpha	Homo sapiens	141-145
9126706-7	1997	Non-oxidative depletion of intracellular glutathione also attenuated the effects of IL-1 on MCP-1 expression.	Glutathione	41-52	interleukin 1 alpha	Homo sapiens	84-88
9114567-5	1997	The maximum response was obtained with 10 ng/ml of IL-1 alpha by counting the viable cell number using trypan blue.	Trypan Blue	103-114	interleukin 1 alpha	Homo sapiens	51-61
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 alpha	Homo sapiens	0-4
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	rasmc	163-168	interleukin 1 alpha	Homo sapiens	0-4
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	227-230	interleukin 1 alpha	Homo sapiens	0-4
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	bisindolylmaleimide	267-286	interleukin 1 alpha	Homo sapiens	0-4
9036929-0	1997	L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro.	Ascorbic Acid	0-15	interleukin 1 alpha	Homo sapiens	73-82
9036929-0	1997	L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro.	uva	25-28	interleukin 1 alpha	Homo sapiens	73-82
9036929-6	1997	L-Ascorbic acid was able to downregulate IL-1alpha mRNA expression in both UVA-irradiated and nonirradiated cells; however, IL-6 mRNA expression remained unaffected.	Ascorbic Acid	0-15	interleukin 1 alpha	Homo sapiens	41-50
9034269-16	1997	CONCLUSIONS: Pretreatment with amrinone, and to a lesser degree, with dopamine, at clinically relevant concentrations inhibits in vitro IL-1alpha-induced increases in human umbilical vein endothelial cell adhesion molecule concentrations.	Amrinone	31-39	interleukin 1 alpha	Homo sapiens	136-145
9034269-16	1997	CONCLUSIONS: Pretreatment with amrinone, and to a lesser degree, with dopamine, at clinically relevant concentrations inhibits in vitro IL-1alpha-induced increases in human umbilical vein endothelial cell adhesion molecule concentrations.	Dopamine	70-78	interleukin 1 alpha	Homo sapiens	136-145
9179627-8	1997	The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO.	pg	140-142	interleukin 1 alpha	Homo sapiens	32-36
9179627-8	1997	The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO.	pg	140-142	interleukin 1 alpha	Homo sapiens	181-185
9179627-8	1997	The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promote the synthesis of IL-6 and NO.	Phosphorus	143-145	interleukin 1 alpha	Homo sapiens	181-185
9381981-4	1997	In particular, we investigated the earliest intracellular events following the binding of IL-1 alpha to its receptor, involving the inositide signal transduction pathway.	inositide	132-141	interleukin 1 alpha	Homo sapiens	90-100
9381981-6	1997	IL-1 alpha evokes a rapid and transient increase of the PLC beta 1 activity in the nucleus, which causes the hydrolysis of phosphatidylinositol mono- and bis-phosphate.	phosphatidylinositol mono- and bis-phosphate	123-167	interleukin 1 alpha	Homo sapiens	0-10
9381981-7	1997	In response to IL-1 alpha, not only the canonical inositol lipid pathway appears to be involved; also the 3"-phosphorylated lipids generated by phosphatidylinositol 3-kinase (PI 3-K), which may act as second messengers, appear to be affected.	inositol lipid	50-64	interleukin 1 alpha	Homo sapiens	15-25
9008612-11	1997	The loss of type II collagen from nasal cartilage stimulated with IL-1 alpha was inhibited by BB87, an inhibitor of both collagenases and gelatinases, and by BB3003, a selective inhibitor of gelatinase A.	bb87	94-98	interleukin 1 alpha	Homo sapiens	66-76
9008612-11	1997	The loss of type II collagen from nasal cartilage stimulated with IL-1 alpha was inhibited by BB87, an inhibitor of both collagenases and gelatinases, and by BB3003, a selective inhibitor of gelatinase A.	bb3003	158-164	interleukin 1 alpha	Homo sapiens	66-76
9512891-2	1997	The effects of interleukin-1 alpha (IL-1 alpha) on GAG metabolism in normal and otosclerotic human bone cells as well as its capacity to modulate IL-1 alpha, IL-1 beta and IL-6 secretion in both populations was analyzed.	Glycosaminoglycans	51-54	interleukin 1 alpha	Homo sapiens	36-46
9512891-8	1997	As the activity of neither enzyme was modified by treatment with IL-1 alpha, the cytokine seems to exert its influences on GAG synthesis rather than on the degradation process.	Glycosaminoglycans	123-126	interleukin 1 alpha	Homo sapiens	65-75
9041375-6	1997	IL-1 significantly increased CS in normal and Apert media, whereas IL-6 enhanced HS and DS in media of both populations.	Chondroitin Sulfates	29-31	interleukin 1 alpha	Homo sapiens	0-4
9043938-10	1997	Addition of monocyte-associated lymphokines, IL-1 and IL-6, showed that IL-1 partially replaced the enhancing effect of all trans-RA previously observed on LPL thymidine incorporation.	Thymidine	160-169	interleukin 1 alpha	Homo sapiens	72-76
9043938-12	1997	We conclude that retinol and retinoid acids (13-cis, all trans-) may alter the human colonic immune system possibly via IL-1 cytokine, but not via IL-6.	Vitamin A	17-24	interleukin 1 alpha	Homo sapiens	120-124
9043938-12	1997	We conclude that retinol and retinoid acids (13-cis, all trans-) may alter the human colonic immune system possibly via IL-1 cytokine, but not via IL-6.	retinoid acids	29-43	interleukin 1 alpha	Homo sapiens	120-124
21533366-14	1997	The significant differences between the two Arms were only: the CD8(+) lymphocytes were decreased in the patients treated with SPG and increased in controls; serum levels of IL-1 alpha was lower in patients treated with SPG than in the control group; the production in culture of IL-1 alpha was higher in Arm A than in Arm B and IL-6 was higher in Arm B than in Arm A.	spirogermanium	220-223	interleukin 1 alpha	Homo sapiens	174-184
21533366-14	1997	The significant differences between the two Arms were only: the CD8(+) lymphocytes were decreased in the patients treated with SPG and increased in controls; serum levels of IL-1 alpha was lower in patients treated with SPG than in the control group; the production in culture of IL-1 alpha was higher in Arm A than in Arm B and IL-6 was higher in Arm B than in Arm A.	spirogermanium	220-223	interleukin 1 alpha	Homo sapiens	280-290
9066525-7	1997	Interfacial membrane mononuclear cells also produced high levels of interleukin-1 alpha, interleukin-1 beta, and prostaglandin E2 and expressed bone resorptive activities following stimulation with either titanium or chromium orthophosphate.	chromic phosphate	217-240	interleukin 1 alpha	Homo sapiens	68-87
9000541-4	1997	PTK inhibition with genistein or herbimycin A blocks LPSa-stimulated secretion of tumor necrosis factor (TNF) and interleukin-1 (IL-1).	herbimycin	33-45	interleukin 1 alpha	Homo sapiens	114-134
9296336-5	1997	The ratio of 1,25(OH)2D/25-OH-D in RA SF, which is presumed to reflect the activity of 25-OH-D-1-hydroxylase (1-OH-ase), was positively correlated with the levels of interleukin-1alpha (IL-1alpha), IL-1beta, and IL-2 in such SF, and was significantly higher than that in sera from RA patients.	25-oh-d	24-31	interleukin 1 alpha	Homo sapiens	166-184
9296336-5	1997	The ratio of 1,25(OH)2D/25-OH-D in RA SF, which is presumed to reflect the activity of 25-OH-D-1-hydroxylase (1-OH-ase), was positively correlated with the levels of interleukin-1alpha (IL-1alpha), IL-1beta, and IL-2 in such SF, and was significantly higher than that in sera from RA patients.	25-oh-d	24-31	interleukin 1 alpha	Homo sapiens	186-195
9027784-2	1997	METHODS: Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic haemodialysis by means of either polysulphone (10 patients) or cuprophane membranes (10 patients) and compared to that of normal controls.	polysulfone P 1700	185-197	interleukin 1 alpha	Homo sapiens	23-27
9027784-2	1997	METHODS: Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic haemodialysis by means of either polysulphone (10 patients) or cuprophane membranes (10 patients) and compared to that of normal controls.	cuprammonium cellulose	215-225	interleukin 1 alpha	Homo sapiens	23-27
8940020-4	1996	Further characterization of this group of peptides has led to a 15-mer, AF12198, Ac-FEWTPGWYQJYALPL-NH2 (J represents the unnatural amino acid, 2-azetidine-1-carboxylic acid), with both in vitro and in vivo IL-1 antagonist activity.	ac-fewtpgwyqjyalpl	81-99	interleukin 1 alpha	Homo sapiens	207-211
9029455-0	1997	Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia.	Phenytoin	0-9	interleukin 1 alpha	Homo sapiens	125-138
9010681-4	1996	Inhibition by okadaic acid of serine/threonine specific phosphatases resulted in a marked increase in interleukin-1 stimulated MEK and MAP kinase activities.	Okadaic Acid	14-26	interleukin 1 alpha	Homo sapiens	102-115
9086447-12	1996	HSE cells produced hyaluronic acid (HA) at a constitutive rate of 200-800 ng/10(5) cells/24 h, which could be upregulated when the cells were incubated with either IL-1 alpha or aFGF.	Hyaluronic Acid	19-34	interleukin 1 alpha	Homo sapiens	164-174
9086447-12	1996	HSE cells produced hyaluronic acid (HA) at a constitutive rate of 200-800 ng/10(5) cells/24 h, which could be upregulated when the cells were incubated with either IL-1 alpha or aFGF.	Hyaluronic Acid	36-38	interleukin 1 alpha	Homo sapiens	164-174
8938138-0	1996	Sensitization by interleukin-1alpha of carboplatinum anti-tumor activity against human ovarian (NIH:OVCAR-3) carcinoma cells in vitro and in vivo.	Carboplatin	39-52	interleukin 1 alpha	Homo sapiens	17-35
8938138-2	1996	In this study, we found that IL-1alpha potentiated the cytotoxicity of carboplatin in human ovarian NIH:OVCAR-3 cancer cells during simultaneous drug exposure in vitro.	Carboplatin	71-82	interleukin 1 alpha	Homo sapiens	29-38
8938138-4	1996	Both carboplatin and IL-1alpha as single agents inhibited the growth of NIH:OVCAR-3 cells grown as xenograft in nude mice; however, carboplatin was more effective in delaying tumor growth, and this inhibition was dose-dependent.	Carboplatin	132-143	interleukin 1 alpha	Homo sapiens	21-30
8938138-5	1996	Treatment with IL-1alpha followed by carboplatin caused a significant delay in tumor growth, resulting in a significant enhancement (4-fold) of the anti-tumor effect of carboplatin.	Carboplatin	169-180	interleukin 1 alpha	Homo sapiens	15-24
8938138-6	1996	In vitro potentiation of carboplatin cytotoxicity by IL-1alpha did not involve formation of nitric oxide as IL-1 or combinations of IL-1 with carboplatin failed to modulate basal nitric oxide production in OVCAR-3 cells.	Carboplatin	25-36	interleukin 1 alpha	Homo sapiens	53-62
8938138-6	1996	In vitro potentiation of carboplatin cytotoxicity by IL-1alpha did not involve formation of nitric oxide as IL-1 or combinations of IL-1 with carboplatin failed to modulate basal nitric oxide production in OVCAR-3 cells.	Carboplatin	25-36	interleukin 1 alpha	Homo sapiens	53-57
8938138-7	1996	Potentiation of the anti-tumor activity of carboplatin by IL-1alpha was due to a significant (3- to 4-fold) increase in the accumulation of total Pt in IL-1-treated tumor xenograft, resulting in a 2-fold increase in DNA-Pt adduct formation in these tumors.	Carboplatin	43-54	interleukin 1 alpha	Homo sapiens	58-67
8938138-7	1996	Potentiation of the anti-tumor activity of carboplatin by IL-1alpha was due to a significant (3- to 4-fold) increase in the accumulation of total Pt in IL-1-treated tumor xenograft, resulting in a 2-fold increase in DNA-Pt adduct formation in these tumors.	Carboplatin	43-54	interleukin 1 alpha	Homo sapiens	58-62
8938138-7	1996	Potentiation of the anti-tumor activity of carboplatin by IL-1alpha was due to a significant (3- to 4-fold) increase in the accumulation of total Pt in IL-1-treated tumor xenograft, resulting in a 2-fold increase in DNA-Pt adduct formation in these tumors.	Platinum	146-148	interleukin 1 alpha	Homo sapiens	58-67
8938138-7	1996	Potentiation of the anti-tumor activity of carboplatin by IL-1alpha was due to a significant (3- to 4-fold) increase in the accumulation of total Pt in IL-1-treated tumor xenograft, resulting in a 2-fold increase in DNA-Pt adduct formation in these tumors.	Platinum	146-148	interleukin 1 alpha	Homo sapiens	58-62
8938138-9	1996	The potent synergy of IL-1alpha and carboplatin in vitro and in vivo against ovarian carcinoma cells suggests that combinations of carboplatinum and interleukin-1alpha may be effective against this disease in the clinic.	Carboplatin	36-47	interleukin 1 alpha	Homo sapiens	149-167
8938138-9	1996	The potent synergy of IL-1alpha and carboplatin in vitro and in vivo against ovarian carcinoma cells suggests that combinations of carboplatinum and interleukin-1alpha may be effective against this disease in the clinic.	Carboplatin	131-144	interleukin 1 alpha	Homo sapiens	22-31
9342758-6	1997	Cytokine secretion capacity was significantly altered in LASM which exhibited reduced TNF alpha and IL-6, but elevated IL-1 alpha secretion when compared to control SM.	lasm	57-61	interleukin 1 alpha	Homo sapiens	119-129
9449167-0	1997	Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/IL-6 ratio.	Biafine	0-7	interleukin 1 alpha	Homo sapiens	91-100
9449167-5	1997	As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-1/IL-6 ratio, chiefly by reducing the secretion of IL-6.	Biafine	42-49	interleukin 1 alpha	Homo sapiens	99-103
9003388-0	1996	2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC).	Mercaptoethanol	0-17	interleukin 1 alpha	Homo sapiens	115-128
9003388-0	1996	2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC).	pyrollidine dithiocarbamate	158-185	interleukin 1 alpha	Homo sapiens	115-128
9003388-0	1996	2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC).	prolinedithiocarbamate	187-191	interleukin 1 alpha	Homo sapiens	115-128
9048875-4	1996	Using lipopolysaccharide (LPS)-stimulated cells, sulphatide increased the IL-2 production (163 +/- 17% of controls without sulphatide, p = 0.02), and gal-cer increased the IL-1 alpha production (145 +/- 13%, p = 0.006), whereas neither gal-cer nor sulphatide had an effect on the production of IL-6, IL-10 or TNF alpha.	Galactosylceramides	150-157	interleukin 1 alpha	Homo sapiens	172-182
20650257-9	1996	Small amounts of oleic acid induced IL-1alpha mRNA expression in submerged keratinocyte cultures, whereas in RE-DED and in excised skin, IL-1alpha mRNA levels were increased only when the concentration applied topically was at least two orders of magnitude higher.	Oleic Acid	17-27	interleukin 1 alpha	Homo sapiens	36-45
8940020-4	1996	Further characterization of this group of peptides has led to a 15-mer, AF12198, Ac-FEWTPGWYQJYALPL-NH2 (J represents the unnatural amino acid, 2-azetidine-1-carboxylic acid), with both in vitro and in vivo IL-1 antagonist activity.	Amido radical	100-103	interleukin 1 alpha	Homo sapiens	207-211
8940020-4	1996	Further characterization of this group of peptides has led to a 15-mer, AF12198, Ac-FEWTPGWYQJYALPL-NH2 (J represents the unnatural amino acid, 2-azetidine-1-carboxylic acid), with both in vitro and in vivo IL-1 antagonist activity.	2-azetidine-1-carboxylic acid	144-173	interleukin 1 alpha	Homo sapiens	207-211
8950199-3	1996	Since reactive oxygen species (ROS) have been implicated in catabolic cytokine action and preliminary data suggested that catabolic cytokines such as TNF-alpha, IL-1 alpha, IL-1 beta and IL-6 are responsible for fibronectin fragment mediated damage, selected anti-oxidants (AOs) were tested as inhibitors of cytokine.	Reactive Oxygen Species	31-34	interleukin 1 alpha	Homo sapiens	161-171
9024987-3	1996	Here we report that tepoxalin selectively inhibits intercellular adhesion molecule-1 (ICAM-1, CD54)/MAC-1 (CD11b/CD18) dependent adhesion of polymorphonuclear cells to IL-1 activated human umbilical vein endothelial cells.	tepoxalin	20-29	interleukin 1 alpha	Homo sapiens	168-172
8912565-0	1996	A characteristic eruption associated with ifosfamide, carboplatin, and etoposide chemotherapy after pretreatment with recombinant interleukin-1 alpha.	Ifosfamide	42-52	interleukin 1 alpha	Homo sapiens	130-149
8912565-0	1996	A characteristic eruption associated with ifosfamide, carboplatin, and etoposide chemotherapy after pretreatment with recombinant interleukin-1 alpha.	Carboplatin	54-65	interleukin 1 alpha	Homo sapiens	130-149
8912565-0	1996	A characteristic eruption associated with ifosfamide, carboplatin, and etoposide chemotherapy after pretreatment with recombinant interleukin-1 alpha.	Etoposide	71-80	interleukin 1 alpha	Homo sapiens	130-149
8875957-1	1996	This study was focused on the characterization of the metabolism of linoleic acid by human dermal fibroblasts and the effect of interleukin-1 on the biosynthesis of octadecanoids.	octadecanoids	165-178	interleukin 1 alpha	Homo sapiens	128-141
8957229-7	1996	FR167653 can act as a protective drug in lipopolysaccharide-induced DIC, and this protection is due to an inhibition of increased plasma interleukin-1 and TNF-alpha.	FR 167653	0-8	interleukin 1 alpha	Homo sapiens	137-150
8982293-3	1996	After 5 d exposure to ATRA 10(-6) M APL-treated samples showed a significant reduction of IL-6 (p = 0.008) and GM-CSF (p = 0.03) and a significant increase of IL-1 alpha (p = 0.01) production, if compared to untreated APL samples.	Tretinoin	22-26	interleukin 1 alpha	Homo sapiens	159-169
8823366-0	1996	Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes.	Helium	11-17	interleukin 1 alpha	Homo sapiens	52-71
8824559-2	1996	Two hygromycin-resistant colonies, colony 3 and colony 6, which respectively do not and do express and release IL-1, were selected on the basis of Northern blot and ELISA.	hygromycin A	4-14	interleukin 1 alpha	Homo sapiens	111-115
23194965-0	1996	Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes.	Capsaicin	35-44	interleukin 1 alpha	Homo sapiens	48-66
23194965-0	1996	Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes.	Arachidonic Acid	115-131	interleukin 1 alpha	Homo sapiens	48-66
23194965-0	1996	Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes.	Leukotriene B4	133-146	interleukin 1 alpha	Homo sapiens	48-66
23194965-0	1996	Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes.	Prostaglandins E	154-169	interleukin 1 alpha	Homo sapiens	48-66
8772198-6	1996	By contrast, proMMP-3/prostromelysin 1 is up-regulated by TNFalpha or TPA in the presence of IL-1alpha, whose modulation is PKC-dependent.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 alpha	Homo sapiens	93-102
8772198-7	1996	The suppressive effect of IL-1alpha on the TNFalpha-induced proMMP-9 production is a new biological effect of IL-1 on MMP production.	prommp-9	60-68	interleukin 1 alpha	Homo sapiens	26-35
8772198-7	1996	The suppressive effect of IL-1alpha on the TNFalpha-induced proMMP-9 production is a new biological effect of IL-1 on MMP production.	prommp-9	60-68	interleukin 1 alpha	Homo sapiens	26-30
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	72-78	interleukin 1 alpha	Homo sapiens	17-26
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	108-110	interleukin 1 alpha	Homo sapiens	17-26
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	139-145	interleukin 1 alpha	Homo sapiens	17-26
8702551-7	1996	The induction of IL-1alpha by TNF can also be decreased by growth in 3% oxygen as compared to growth in 21% O2; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein.	Oxygen	139-145	interleukin 1 alpha	Homo sapiens	172-181
8702551-8	1996	The effect of Mn-SOD overexpression on IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	126-157	interleukin 1 alpha	Homo sapiens	39-48
8702551-9	1996	Mn-SOD overexpression and low oxygen alter IL-1alpha mRNA levels by decreasing the stability of the IL-1alpha mRNA.	Oxygen	30-36	interleukin 1 alpha	Homo sapiens	43-52
8702551-9	1996	Mn-SOD overexpression and low oxygen alter IL-1alpha mRNA levels by decreasing the stability of the IL-1alpha mRNA.	Oxygen	30-36	interleukin 1 alpha	Homo sapiens	100-109
8702551-10	1996	These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF-induced IL-1alpha expression, presumably superoxide.	Oxygen	45-47	interleukin 1 alpha	Homo sapiens	133-142
8702551-10	1996	These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF-induced IL-1alpha expression, presumably superoxide.	Superoxides	166-176	interleukin 1 alpha	Homo sapiens	133-142
8918695-5	1996	Surprisingly, blocking experiments with sIL-4R and anti-IL-4 mAb revealed that in three out of four Th2 cell clones this effect of IL-1 was IL-4-independent and could also not be blocked by cyclosporin A (CsA).	Cyclosporine	205-208	interleukin 1 alpha	Homo sapiens	131-135
8692926-1	1996	Interleukin 1 is the prototype of an inflammatory cytokine, and evidence suggests that it uses the sphingomyelin pathway and ceramide production to trigger mitogen-activated protein kinase (MAPK) activation and subsequent gene expression required for acute inflammatory processes.	Sphingomyelins	99-112	interleukin 1 alpha	Homo sapiens	0-13
8692926-1	1996	Interleukin 1 is the prototype of an inflammatory cytokine, and evidence suggests that it uses the sphingomyelin pathway and ceramide production to trigger mitogen-activated protein kinase (MAPK) activation and subsequent gene expression required for acute inflammatory processes.	Ceramides	125-133	interleukin 1 alpha	Homo sapiens	0-13
8807591-9	1996	The IL-1-induced-sTNF-R1-shedding was suppressed by the protein-kinase-A (PKA) inhibitor, H-8, or by H-7, the inhibitor of both PKC and PKA, but not by the specific PKC inhibitor GF.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	90-93	interleukin 1 alpha	Homo sapiens	4-8
8807591-9	1996	The IL-1-induced-sTNF-R1-shedding was suppressed by the protein-kinase-A (PKA) inhibitor, H-8, or by H-7, the inhibitor of both PKC and PKA, but not by the specific PKC inhibitor GF.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	101-104	interleukin 1 alpha	Homo sapiens	4-8
8807591-9	1996	The IL-1-induced-sTNF-R1-shedding was suppressed by the protein-kinase-A (PKA) inhibitor, H-8, or by H-7, the inhibitor of both PKC and PKA, but not by the specific PKC inhibitor GF.	glycylphenylalanine	179-181	interleukin 1 alpha	Homo sapiens	4-8
8941662-2	1996	The present study identifies the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK)-1 and ERK-2 as major tyrosine phosphorylated proteins in IL-1 stimulated chondrocytes.	Tyrosine	138-146	interleukin 1 alpha	Homo sapiens	174-178
8950199-6	1996	The AO, N-acetylcysteine (NAC), decreased the extent of cartilage PG depletion caused by TNF-alpha and IL-1 alpha and by the ROS, hydrogen peroxide and superoxide anion, confirming that the cytokines operate through ROS and that ROS can initiate cartilage PG depletion.	Acetylcysteine	8-24	interleukin 1 alpha	Homo sapiens	103-113
8950199-6	1996	The AO, N-acetylcysteine (NAC), decreased the extent of cartilage PG depletion caused by TNF-alpha and IL-1 alpha and by the ROS, hydrogen peroxide and superoxide anion, confirming that the cytokines operate through ROS and that ROS can initiate cartilage PG depletion.	Acetylcysteine	26-29	interleukin 1 alpha	Homo sapiens	103-113
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	31-44	interleukin 1 alpha	Homo sapiens	366-379
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Tetradecanoylphorbol Acetate	109-140	interleukin 1 alpha	Homo sapiens	366-379
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	249-262	interleukin 1 alpha	Homo sapiens	366-379
8878515-3	1996	These data suggest that increased IL-6 production after stimulation by either interleukin-1 or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine.	sil-6r	162-168	interleukin 1 alpha	Homo sapiens	78-122
8897833-4	1996	These effects of IL-1 alpha are directly correlated with SEMF prostaglandin E2 (PGE2) production.	semf	57-61	interleukin 1 alpha	Homo sapiens	17-27
8897833-4	1996	These effects of IL-1 alpha are directly correlated with SEMF prostaglandin E2 (PGE2) production.	Dinoprostone	62-78	interleukin 1 alpha	Homo sapiens	17-27
8897833-4	1996	These effects of IL-1 alpha are directly correlated with SEMF prostaglandin E2 (PGE2) production.	Dinoprostone	80-84	interleukin 1 alpha	Homo sapiens	17-27
8897833-10	1996	The effects of IL-1 alpha on SEMF PGE2 productions are, at least in part, due to stimulation of COX gene expression.	Dinoprostone	34-38	interleukin 1 alpha	Homo sapiens	15-25
8837751-0	1996	Failure of tumor necrosis factor and interleukin-1 to elicit superoxide production in the mitochondrial matrices of mammalian cells.	Superoxides	61-71	interleukin 1 alpha	Homo sapiens	37-50
8837751-1	1996	Subversion of mitochondrial electron transport to the production of O2.- has been proposed as a mechanism of tumor necrosis factor (TNF)-mediated cell killing and to a lesser extent interleukin-1 (IL-1) and lipopolysaccharide (LPS) cytotoxicity.	Superoxides	68-70	interleukin 1 alpha	Homo sapiens	182-195
8837751-1	1996	Subversion of mitochondrial electron transport to the production of O2.- has been proposed as a mechanism of tumor necrosis factor (TNF)-mediated cell killing and to a lesser extent interleukin-1 (IL-1) and lipopolysaccharide (LPS) cytotoxicity.	Superoxides	68-70	interleukin 1 alpha	Homo sapiens	197-201
8894717-1	1996	Bradykinin (BK)2 and interleukin-1 (IL-1) interact synergistically to stimulate prostaglandin synthesis in human synovial fibroblast-like cells.	Prostaglandins	80-93	interleukin 1 alpha	Homo sapiens	21-34
8894717-1	1996	Bradykinin (BK)2 and interleukin-1 (IL-1) interact synergistically to stimulate prostaglandin synthesis in human synovial fibroblast-like cells.	Prostaglandins	80-93	interleukin 1 alpha	Homo sapiens	36-40
8894717-6	1996	IL-1, in contrast, increased prostaglandins but not AA, above basal levels.	Prostaglandins	29-43	interleukin 1 alpha	Homo sapiens	0-4
8894717-11	1996	In addition, these data extend the results of previous investigations in demonstrating that basal phospholipase activity provides sufficient AA substrate for IL-1 induced prostanoid synthesis without invoking the concomitant induction of phospholipase activity by IL-1.	Prostaglandins	171-181	interleukin 1 alpha	Homo sapiens	158-162
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	138-147	interleukin 1 alpha	Homo sapiens	15-19
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	138-147	interleukin 1 alpha	Homo sapiens	102-106
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	138-147	interleukin 1 alpha	Homo sapiens	102-106
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	234-243	interleukin 1 alpha	Homo sapiens	15-19
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	234-243	interleukin 1 alpha	Homo sapiens	102-106
8936495-7	1996	Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release.	Serotonin	234-243	interleukin 1 alpha	Homo sapiens	102-106
8936495-8	1996	We therefore hypothesize that during tumor growth, increased production/secretion of IL-1 occurs, which facilitates the tryptophan supply to the brain.	Tryptophan	120-130	interleukin 1 alpha	Homo sapiens	85-89
8936495-9	1996	IL-1 can then also act on the VHM itself, where IL-1 receptors exist, to increase its neuronal activity and serotonin release.	Serotonin	108-117	interleukin 1 alpha	Homo sapiens	0-4
8936495-9	1996	IL-1 can then also act on the VHM itself, where IL-1 receptors exist, to increase its neuronal activity and serotonin release.	Serotonin	108-117	interleukin 1 alpha	Homo sapiens	48-52
8936495-10	1996	In other words, we believe that centrally acting IL-1 increases hypothalamic neuronal firing rate and serotonin release, while peripherally acting IL-1 is critical in supplying the hypothalamus with the precursor, tryptophan, in order to maintain the high rate of serotonin synthesis.	Serotonin	102-111	interleukin 1 alpha	Homo sapiens	49-53
8936495-10	1996	In other words, we believe that centrally acting IL-1 increases hypothalamic neuronal firing rate and serotonin release, while peripherally acting IL-1 is critical in supplying the hypothalamus with the precursor, tryptophan, in order to maintain the high rate of serotonin synthesis.	Tryptophan	214-224	interleukin 1 alpha	Homo sapiens	147-151
8936495-10	1996	In other words, we believe that centrally acting IL-1 increases hypothalamic neuronal firing rate and serotonin release, while peripherally acting IL-1 is critical in supplying the hypothalamus with the precursor, tryptophan, in order to maintain the high rate of serotonin synthesis.	Serotonin	264-273	interleukin 1 alpha	Homo sapiens	147-151
8798439-7	1996	The addition of the NO donor S-nitroso-acetylpenicillamine reconstituted the release of IL-1 bioactivity inhibited by NMMA in a concentration-dependent manner.	S-Nitroso-N-Acetylpenicillamine	29-58	interleukin 1 alpha	Homo sapiens	88-92
8798439-7	1996	The addition of the NO donor S-nitroso-acetylpenicillamine reconstituted the release of IL-1 bioactivity inhibited by NMMA in a concentration-dependent manner.	nmma	118-122	interleukin 1 alpha	Homo sapiens	88-92
8798439-9	1996	A cGMP donor, 8-bromo-cGMP, dose-dependently reverses NMMA inhibition of bioactive IL-1 release, suggesting that NO regulates IL-1 release by a cGMP-dependent mechanism.	Cyclic GMP	2-6	interleukin 1 alpha	Homo sapiens	126-130
8798439-9	1996	A cGMP donor, 8-bromo-cGMP, dose-dependently reverses NMMA inhibition of bioactive IL-1 release, suggesting that NO regulates IL-1 release by a cGMP-dependent mechanism.	8-bromocyclic GMP	14-26	interleukin 1 alpha	Homo sapiens	126-130
8798439-9	1996	A cGMP donor, 8-bromo-cGMP, dose-dependently reverses NMMA inhibition of bioactive IL-1 release, suggesting that NO regulates IL-1 release by a cGMP-dependent mechanism.	nmma	54-58	interleukin 1 alpha	Homo sapiens	126-130
8798439-9	1996	A cGMP donor, 8-bromo-cGMP, dose-dependently reverses NMMA inhibition of bioactive IL-1 release, suggesting that NO regulates IL-1 release by a cGMP-dependent mechanism.	Cyclic GMP	22-26	interleukin 1 alpha	Homo sapiens	126-130
8886420-14	1996	Experiments using cycloheximide demonstrated that this synergistic effect of IL-13 and IL-1 alpha on IL-8 secretion was not through de novo protein synthesis.	Cycloheximide	18-31	interleukin 1 alpha	Homo sapiens	87-97
8756544-11	1996	Importantly, progesterone suppressed both basal and IL-1 alpha-stimulated IL-8 expression in stromal and granulosa-lutein cell types.	Progesterone	13-25	interleukin 1 alpha	Homo sapiens	52-62
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Dinoprostone	133-149	interleukin 1 alpha	Homo sapiens	43-53
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Dinoprostone	151-155	interleukin 1 alpha	Homo sapiens	43-53
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Calcitriol	181-201	interleukin 1 alpha	Homo sapiens	43-53
8806873-3	1996	This in vitro system displays many of the functional and metabolic properties of a differentiated epidermis and can be induced to specifically release IL-1 alpha in response to a mixture of lipopolysaccharide and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	213-238	interleukin 1 alpha	Homo sapiens	151-161
8806873-5	1996	This response was confirmed in primary keratinocytes, which were also shown to secrete IL-1 alpha into media supernatants after incubation with phosphorothioate oligomers.	Parathion	144-160	interleukin 1 alpha	Homo sapiens	87-97
8753812-0	1996	Production of granulocyte colony-stimulating factor by THP-1 cells in response to retinoic acid and phorbol ester is mediated through the autocrine production of interleukin-1.	Tretinoin	82-95	interleukin 1 alpha	Homo sapiens	162-175
8753812-0	1996	Production of granulocyte colony-stimulating factor by THP-1 cells in response to retinoic acid and phorbol ester is mediated through the autocrine production of interleukin-1.	Phorbol Esters	100-113	interleukin 1 alpha	Homo sapiens	162-175
8770057-12	1996	Amiloride also inhibited IL-8 release from A549 cells stimulated with IL-1 or tumor necrosis factor.	Amiloride	0-9	interleukin 1 alpha	Homo sapiens	70-74
8842442-8	1996	Genistein inhibited VCAM-1 expression induced by incubation of HUVEC for 24 h with TNF alpha or IL-1 alpha whereas it did not affect ICAM-1 expression induced by 24 h incubation with either of these cytokines.	Genistein	0-9	interleukin 1 alpha	Homo sapiens	96-106
8899296-4	1996	One of the recently described "long" pentraxins (TSG-14/PTX3) is inducible by TNF or IL-1 and is produced during the acute phase response.	pentraxins	37-47	interleukin 1 alpha	Homo sapiens	85-89
8911126-1	1996	The aim of this study was to evaluate the safety and the biological effects of interleukin (IL-1 alpha) in patients" with recurrent ovarian carcinoma treated with carboplatin.	Carboplatin	163-174	interleukin 1 alpha	Homo sapiens	92-102
8911126-2	1996	In this phase I study, IL-1 alpha was administered by a continuous intravenous infusion at doses ranging 0.1-10 micrograms/m2 every 24 h for 4 days (96 h) 3 weeks before the first dose of carboplatin (400 mg/m2) in patients with potentially platinum-sensitive ovarian cancer.	Carboplatin	188-199	interleukin 1 alpha	Homo sapiens	23-33
8911126-2	1996	In this phase I study, IL-1 alpha was administered by a continuous intravenous infusion at doses ranging 0.1-10 micrograms/m2 every 24 h for 4 days (96 h) 3 weeks before the first dose of carboplatin (400 mg/m2) in patients with potentially platinum-sensitive ovarian cancer.	Platinum	241-249	interleukin 1 alpha	Homo sapiens	23-33
8678906-2	1996	We demonstrate here that tenidap inhibits the zymosan-induced expression of both interleukin 1 and tumor necrosis factor alpha in macrophages, at the mRNA and protein levels.	Zymosan	46-53	interleukin 1 alpha	Homo sapiens	81-126
8872139-0	1996	Interleukin-1 alpha induces variations of the intranuclear amount of phosphatidylinositol 4,5-bisphosphate and phospholipase C beta 1 in human osteosarcoma Saos-2 cells.	Phosphatidylinositol 4,5-Diphosphate	69-106	interleukin 1 alpha	Homo sapiens	0-19
8872139-4	1996	In this study we report immunocytochemical ultrastructural evidence on quantitative variations of PIP2 and phospholipase C beta 1 amounts in the nucleus of Saos-2 cells at different times of exposure to interleukin-1 alpha.	Phosphatidylinositol 4,5-Diphosphate	98-102	interleukin 1 alpha	Homo sapiens	203-222
8872139-6	1996	After longer periods of incubation with interleukin-1 alpha, on the other hand, the intranuclear amount of PIP2 is restored to initial level, while the amount of phospholipase C beta 1 is increased both at the nuclear and cytoplasmic level, when its activation is no longer effective.	Phosphatidylinositol 4,5-Diphosphate	107-111	interleukin 1 alpha	Homo sapiens	40-59
8844228-15	1996	In both trauma and sepsis patients, the usual deterioration in platelet function was even attenuated, which may be due to the effects of PTX on cytokine release (e.g., reduction in tumor necrosis factor and interleukin-1), improvement in microcirculation, or additional fibrinolytic effects.	Pentoxifylline	137-140	interleukin 1 alpha	Homo sapiens	207-220
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	107-119	interleukin 1 alpha	Homo sapiens	48-73
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	107-119	interleukin 1 alpha	Homo sapiens	75-79
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	121-125	interleukin 1 alpha	Homo sapiens	48-73
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	121-125	interleukin 1 alpha	Homo sapiens	75-79
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	6-keto pgf1	129-140	interleukin 1 alpha	Homo sapiens	48-73
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	6-keto pgf1	129-140	interleukin 1 alpha	Homo sapiens	75-79
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	152-168	interleukin 1 alpha	Homo sapiens	48-73
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	152-168	interleukin 1 alpha	Homo sapiens	75-79
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	170-174	interleukin 1 alpha	Homo sapiens	48-73
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	170-174	interleukin 1 alpha	Homo sapiens	75-79
8796788-3	1996	IL-1, but not IL-6 or IL-8, caused a dose- and time-dependent increase in the production of both PGI2 and PGE2.	Epoprostenol	97-101	interleukin 1 alpha	Homo sapiens	0-4
8796788-3	1996	IL-1, but not IL-6 or IL-8, caused a dose- and time-dependent increase in the production of both PGI2 and PGE2.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	0-4
8796788-5	1996	The action of IL-1 was greatly potentiated by the protein kinase C-activating phorbol ester, TPA, and inhibited by actinomycin D and cycloheximide.	Phorbol Esters	78-91	interleukin 1 alpha	Homo sapiens	14-18
8796788-5	1996	The action of IL-1 was greatly potentiated by the protein kinase C-activating phorbol ester, TPA, and inhibited by actinomycin D and cycloheximide.	Tetradecanoylphorbol Acetate	93-96	interleukin 1 alpha	Homo sapiens	14-18
8796788-5	1996	The action of IL-1 was greatly potentiated by the protein kinase C-activating phorbol ester, TPA, and inhibited by actinomycin D and cycloheximide.	Dactinomycin	115-128	interleukin 1 alpha	Homo sapiens	14-18
8796788-5	1996	The action of IL-1 was greatly potentiated by the protein kinase C-activating phorbol ester, TPA, and inhibited by actinomycin D and cycloheximide.	Cycloheximide	133-146	interleukin 1 alpha	Homo sapiens	14-18
8796788-6	1996	IL-1-induced PG production was also suppressed by dexamethasone, by the natural IL-1 receptor antagonist (IL-1ra), and by transforming growth factor1 beta (TGF1 beta).	Prostaglandins	13-15	interleukin 1 alpha	Homo sapiens	0-4
8796788-6	1996	IL-1-induced PG production was also suppressed by dexamethasone, by the natural IL-1 receptor antagonist (IL-1ra), and by transforming growth factor1 beta (TGF1 beta).	Dexamethasone	50-63	interleukin 1 alpha	Homo sapiens	0-4
8796788-7	1996	It is concluded that IL-1 is a potent agonist of PG synthesis in human myometrial cells, acting by a mechanism dependent on the synthesis of new proteins, presumably key enzymes (phospholipase A2 and/or cyclo-oxygenase-2).	Prostaglandins	49-51	interleukin 1 alpha	Homo sapiens	21-25
8660820-0	1996	Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, and it antifibrotic effects in vivo.	acanthoic acid	75-89	interleukin 1 alpha	Homo sapiens	15-60
8660820-0	1996	Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, and it antifibrotic effects in vivo.	(-)-pimara-9	91-103	interleukin 1 alpha	Homo sapiens	15-60
8660820-0	1996	Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, and it antifibrotic effects in vivo.	15-dien-19-oic acid	108-127	interleukin 1 alpha	Homo sapiens	15-60
8660820-4	1996	When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all.	Silicon Dioxide	49-55	interleukin 1 alpha	Homo sapiens	125-129
8660820-4	1996	When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all.	acanthoic acid	91-105	interleukin 1 alpha	Homo sapiens	125-129
8660820-13	1996	Taken together, these data indicate that acanthoic acid has a potent anti-inflammatory and antifibrosis effect by reducing IL-1 and TNF-alpha production.	acanthoic acid	41-55	interleukin 1 alpha	Homo sapiens	123-127
8662657-3	1996	HUVEC treated with aspirin lost their capacity to generate PGs but recovery occurred after 3- or 6-h induction of Cox-2 with phorbol ester or IL-1alpha.	Aspirin	19-26	interleukin 1 alpha	Homo sapiens	142-151
8635290-4	1996	In contrast, both (O2)- generation and enzyme induction were attenuated by priming with IL1-alpha, with the exception of PMA-stimulated (O2)- generation.	Superoxides	19-21	interleukin 1 alpha	Homo sapiens	88-97
8675151-4	1996	Dose-dependent increases in superoxide release, interleukin-1 (IL-1) release, and, within a relatively narrow range, prostaglandin-E2 (PGE2) release were observed in opsonized zymosan (oz)-stimulated HHMphi derived from both cirrhotic and noncirrhotic patients.	Zymosan	176-183	interleukin 1 alpha	Homo sapiens	63-67
8818192-0	1996	In vitro modulation of epidermal inflammatory cytokines (IL-1 alpha, IL-6, TNF alpha) by minocycline.	Minocycline	89-100	interleukin 1 alpha	Homo sapiens	57-67
8840155-3	1996	In this report, in situ hybridization was used to detect the messenger RNAs for interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) in samples of human skin prior to and at various times after application of urushiol, the immunogenic component of poison ivy/oak.	urushiol	266-274	interleukin 1 alpha	Homo sapiens	80-99
8662657-9	1996	However, in acetylsalicylic acid-treated cells, after 6-h stimulation with IL-1alpha, newly synthesized Cox-2 produced less TXB2 than 6-keto-PGF1alpha compared to untreated cells.	Aspirin	12-32	interleukin 1 alpha	Homo sapiens	75-84
8662657-9	1996	However, in acetylsalicylic acid-treated cells, after 6-h stimulation with IL-1alpha, newly synthesized Cox-2 produced less TXB2 than 6-keto-PGF1alpha compared to untreated cells.	6-Ketoprostaglandin F1 alpha	134-150	interleukin 1 alpha	Homo sapiens	75-84
8809439-10	1996	CONCLUSION: Both IL-1 (alpha and beta) and collagenase are up-regulated around loose THR, suggesting that they may play a role in loosening.	Threonine	85-88	interleukin 1 alpha	Homo sapiens	17-37
8718929-1	1996	The release of interleukin-1 alpha (IL-1 alpha) by human peripheral blood monocytes cultured for 24 and 48 h on polystyrene (PS) and titanium-sputtered polystyrene (Ti) was evaluated.	Polystyrenes	112-123	interleukin 1 alpha	Homo sapiens	15-34
8718929-1	1996	The release of interleukin-1 alpha (IL-1 alpha) by human peripheral blood monocytes cultured for 24 and 48 h on polystyrene (PS) and titanium-sputtered polystyrene (Ti) was evaluated.	Polystyrenes	112-123	interleukin 1 alpha	Homo sapiens	36-46
8718929-1	1996	The release of interleukin-1 alpha (IL-1 alpha) by human peripheral blood monocytes cultured for 24 and 48 h on polystyrene (PS) and titanium-sputtered polystyrene (Ti) was evaluated.	Polystyrenes	125-127	interleukin 1 alpha	Homo sapiens	36-46
8718929-1	1996	The release of interleukin-1 alpha (IL-1 alpha) by human peripheral blood monocytes cultured for 24 and 48 h on polystyrene (PS) and titanium-sputtered polystyrene (Ti) was evaluated.	Polystyrenes	152-163	interleukin 1 alpha	Homo sapiens	36-46
8718929-6	1996	High concentrations of PS particles (1 and 3 microns diameter) were equally effective stimuli for IL-1 alpha release as LPS.	Polystyrenes	23-25	interleukin 1 alpha	Homo sapiens	98-108
8688848-2	1996	By means of anti-BrdU monoclonal antibodies and [3H-thymidine] incorporation a reduced proliferation rate was shown both through a combination of TNF alpha with either IL-1 alpha or IFN alpha and, above all, through simultaneous treatment with the three cytokines.	3h-thymidine	49-61	interleukin 1 alpha	Homo sapiens	168-178
8613463-0	1996	Fibroblast growth factor and heparin protect endothelial cells from the effects of interleukin 1.	Heparin	29-36	interleukin 1 alpha	Homo sapiens	83-96
8613463-7	1996	This study indicates that aFGF/heparin in the culture medium of HUVEC abrogates the measured responses to IL-1.	Heparin	31-38	interleukin 1 alpha	Homo sapiens	106-110
8724299-0	1996	Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	89-93
8724299-5	1996	The addition of PGE2 to cultures stimulated with IL-1 alpha and indomethacin resulted increases in IL-6 mRNA and protein expression while causing a concomitant reduction in GMCSF protein and mRNA expression.	Dinoprostone	16-20	interleukin 1 alpha	Homo sapiens	49-59
8900471-4	1996	In addition, interleukin(IL-)1 alpha is shown to be present in platelet cytoplasm after methanol treatment but not after permeabilization using Fix&amp;Perm.	Methanol	88-96	interleukin 1 alpha	Homo sapiens	13-36
23194856-5	1996	Hypericin also inhibits the production of IL-1alpha in LPS-stimulated human monocytes and activates NO production in isolated human leukocytes.	hypericin	0-9	interleukin 1 alpha	Homo sapiens	42-51
8609410-7	1996	BmA-stimulated supernatants pretreated with anti-IL-1 alone resulted in VCAM-1 expression that was 23.7% of that with untreated supernatants while anti-IL-4, anti-IFN-gamma, or anti-TNF alone had essentially no effect on VCAM-1 expression.	bma	0-3	interleukin 1 alpha	Homo sapiens	49-53
8807194-5	1996	However when PTK inhibitors were present during both agonist activation (2h) and subsequent expression of E-selectin after removal of agonist (4h) the PTK inhibitors resulted in a dose dependent reduction in both IL-1 alpha and LPS stimulated E-selectin expression (IC50 = 50M).	Deuterium	73-75	interleukin 1 alpha	Homo sapiens	213-223
8731107-12	1996	FCCP blocked the cellular production of IL-1 alpha, IL-1 beta, and TNF-alpha, but had little effect on zinc-induced stimulated mononuclear cell supernatant calcitriol levels.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	0-4	interleukin 1 alpha	Homo sapiens	40-50
8807194-5	1996	However when PTK inhibitors were present during both agonist activation (2h) and subsequent expression of E-selectin after removal of agonist (4h) the PTK inhibitors resulted in a dose dependent reduction in both IL-1 alpha and LPS stimulated E-selectin expression (IC50 = 50M).	4h	143-145	interleukin 1 alpha	Homo sapiens	213-223
8793329-5	1996	LH-induced production of IL-1 was also greater (P &lt; 0.01) on proestrus (292 +/- 36 pg/10(6) cells/ ml) and estrus (222 +/- 30 pg/10(6) cells/ml) than on diestrus 1 (34 +/- 15 pg/10(6) cells/ml) or diestrus 2 (117 +/- 16 pg/10(6) cells/ml).	Luteinizing Hormone	0-2	interleukin 1 alpha	Homo sapiens	25-29
8793329-8	1996	The number of macrophages and their response to LH to produce IL-1 were increased significantly (P &lt; 0.01) by estradiol treatment but not by progesterone or testosterone treatment.	Estradiol	113-122	interleukin 1 alpha	Homo sapiens	62-66
8793329-9	1996	It was concluded that the peritoneal macrophages became more sensitive to LH to produce IL-1 on proestrus and estrus in cyclic hamsters, and that these changes in macrophages, probably induced by estradiol, would play important roles in ovarian function.	Luteinizing Hormone	74-76	interleukin 1 alpha	Homo sapiens	88-92
8894802-4	1996	This study demonstrates that phosphorothioate oligodeoxynucleotides can selectively inhibit IL-1r expression leading to a reduction in IL-1 dependent gene expression.	phosphorothioate oligodeoxynucleotides	29-67	interleukin 1 alpha	Homo sapiens	92-96
8728019-3	1996	The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-1 alpha, MIP-2 and MCP-1).	Dexamethasone	29-42	interleukin 1 alpha	Homo sapiens	347-351
8894802-3	1996	Treatment of A549 cells with this oligodeoxynucleotide (but not scrambled controls) inhibited the IL-1 stimulated expression of the cell adhesion molecule ICAM-1 but was without effect on the TNF-alpha induction of this molecule.	Oligodeoxyribonucleotides	34-54	interleukin 1 alpha	Homo sapiens	98-102
8809187-7	1996	In this study, we found that progesterone and a synthetic progestin, medroxyprogesterone acetate (MPA) act to enhance the action of IL-1 to increase the level of IL-8 mRNA; this action of progesterone/MPA appears to be affected principally by the stabilization of IL-8 mRNA, together with a small increase in IL-8 gene transcription.	Medroxyprogesterone Acetate	69-96	interleukin 1 alpha	Homo sapiens	132-136
8618003-4	1996	On Northern blot analysis, the baseline expression of the 1.2-kb POMC transcript was upregulated by ultraviolet radiation (UVR) or by stimulation with interleukin-1 alpha (IL-1 alpha) or phorbol 12-tetradecanoate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	225-228	interleukin 1 alpha	Homo sapiens	151-170
9162528-0	1996	D-mannose dimer introduced human recombinant interleukin- 1 alpha, NEO IL-1 alpha, exhibits altered tissue distribution in mice.	Mannose	2-9	interleukin 1 alpha	Homo sapiens	45-65
9162528-0	1996	D-mannose dimer introduced human recombinant interleukin- 1 alpha, NEO IL-1 alpha, exhibits altered tissue distribution in mice.	Mannose	2-9	interleukin 1 alpha	Homo sapiens	71-81
11862250-3	1996	Misoprostol reproducibly reverses inhibition of proteoglycan synthesis induced by interleukin-1 and certain NSAIDs, and also stimulates synthesis in OA cartilage.	Misoprostol	0-11	interleukin 1 alpha	Homo sapiens	82-95
8657102-4	1996	We found that two residues, serines 32 and 36, were phosphorylated in response to either tumor necrosis factor, interleukin-1, or phorbol ester.	Serine	28-35	interleukin 1 alpha	Homo sapiens	112-125
8608158-0	1996	Interleukin 1 stimulates cholesterol esterification and cholesterol deposition in J774 monocytes-macrophages.	Cholesterol	25-36	interleukin 1 alpha	Homo sapiens	0-13
8608158-0	1996	Interleukin 1 stimulates cholesterol esterification and cholesterol deposition in J774 monocytes-macrophages.	Cholesterol	56-67	interleukin 1 alpha	Homo sapiens	0-13
8608653-5	1996	IL-1alpha production by the TCL from the femoral head was significantly higher than any of the other groups when all the TCL were used for the analysis.	Triclosan	28-31	interleukin 1 alpha	Homo sapiens	0-9
8882622-9	1996	The non-selective PKC inhibitor, staurosporine (1-300 nM) significantly increased the production of IL-1 alpha-induced IL-8 mRNA and protein.	Staurosporine	33-46	interleukin 1 alpha	Homo sapiens	100-110
8882622-18	1996	It is proposed that activation of an isoform of PKC, possibly PKC epsilon or zeta, which is inhibited by higher concentrations of the bisinodolylmaleimides, plays a role in the regulation of chemokine expression induced by IL-1 alpha or TNF alpha in synovial cells.	bisinodolylmaleimides	134-155	interleukin 1 alpha	Homo sapiens	223-233
8833198-3	1996	Primary human astrocytes produced substantial amounts of NO in response to interleukin (IL)-1 alpha or IL-1 beta, which was blocked by the NO synthase inhibitor NG-mono-methyl-L-arginine (NMMA).	omega-N-Methylarginine	161-186	interleukin 1 alpha	Homo sapiens	75-99
8833198-3	1996	Primary human astrocytes produced substantial amounts of NO in response to interleukin (IL)-1 alpha or IL-1 beta, which was blocked by the NO synthase inhibitor NG-mono-methyl-L-arginine (NMMA).	omega-N-Methylarginine	188-192	interleukin 1 alpha	Homo sapiens	75-99
8778024-5	1996	Moreover, the tyrosine phosphorylation caused by the oxidant but not that induced by anti-IgM was markedly augmented by two inflammatory cytokines, tumour necrosis factor-alpha and interleukin-1 alpha, although these agents by themselves did not stimulate PTK activity nor induce tyrosine phosphorylation.	Tyrosine	14-22	interleukin 1 alpha	Homo sapiens	181-200
8778024-5	1996	Moreover, the tyrosine phosphorylation caused by the oxidant but not that induced by anti-IgM was markedly augmented by two inflammatory cytokines, tumour necrosis factor-alpha and interleukin-1 alpha, although these agents by themselves did not stimulate PTK activity nor induce tyrosine phosphorylation.	Tyrosine	280-288	interleukin 1 alpha	Homo sapiens	181-200
8636247-0	1996	Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves" ophthalmopathy.	Glycosaminoglycans	88-105	interleukin 1 alpha	Homo sapiens	0-13
8680773-0	1996	[Comparative characterization of results of the immunoenzyme method of interleukin-1 determination in blast transformation reaction with indomethacin].	Indomethacin	137-149	interleukin 1 alpha	Homo sapiens	71-84
8680773-2	1996	Combined addition of PHA and indomethacin to cell culture by shifting the balance between prostaglandin E and interleukin-1 helps assess the contribution of macrophages to the development of HIV infection.	Indomethacin	29-41	interleukin 1 alpha	Homo sapiens	110-123
8640042-2	1996	The median standardized IL-1 alpha creatinine quotient in children with first-time acute pyelonephritis was 3.6 pg/mumol, but was nondetectable in children with recurrent pyelonephritis, children with non-renal febrile conditions and children convalescent after acute pyelonephritis (p &lt; 0.05-0.01).	Creatinine	35-45	interleukin 1 alpha	Homo sapiens	24-34
8640042-6	1996	The acute IL-1 alpha creatinine quotients were lowest in children with uptake defects on 99mTC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection (reflecting the acute inflammation) (p &lt; 0.001) and 1 year after the acute infection (reflecting permanent kidney scarring) (p &lt; 0.001).	Creatinine	21-31	interleukin 1 alpha	Homo sapiens	10-20
8640042-6	1996	The acute IL-1 alpha creatinine quotients were lowest in children with uptake defects on 99mTC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection (reflecting the acute inflammation) (p &lt; 0.001) and 1 year after the acute infection (reflecting permanent kidney scarring) (p &lt; 0.001).	Technetium Tc 99m Dimercaptosuccinic Acid	89-118	interleukin 1 alpha	Homo sapiens	10-20
8640042-6	1996	The acute IL-1 alpha creatinine quotients were lowest in children with uptake defects on 99mTC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection (reflecting the acute inflammation) (p &lt; 0.001) and 1 year after the acute infection (reflecting permanent kidney scarring) (p &lt; 0.001).	Technetium Tc 99m Dimercaptosuccinic Acid	120-124	interleukin 1 alpha	Homo sapiens	10-20
11859379-9	1996	Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes.	Prostaglandins	66-79	interleukin 1 alpha	Homo sapiens	9-13
11859379-9	1996	Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes.	Leukotrienes	84-95	interleukin 1 alpha	Homo sapiens	9-13
11859379-9	1996	Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes.	Prostaglandins E	144-147	interleukin 1 alpha	Homo sapiens	9-13
11859379-9	1996	Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes.	Prostaglandins E	144-147	interleukin 1 alpha	Homo sapiens	236-240
11859379-10	1996	These findings may indicate that cyclo-oxygenase products such as PGE(2) normally contribute to IL-1 induction of IL-6 expression in chondrocytes, and under conditions when cyclo-oxygenase is inhibited, lipoxygenase products alternatively contribute to this response.	Dinoprostone	66-72	interleukin 1 alpha	Homo sapiens	96-100
8777276-2	1996	IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts.	Dinoprostone	104-120	interleukin 1 alpha	Homo sapiens	0-10
8777276-2	1996	IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts.	Dinoprostone	122-126	interleukin 1 alpha	Homo sapiens	0-10
8729095-8	1996	In further studies, DHA dose- and time-dependently reduced also the expression of E-selectin, Intercellular Adhesion Molecule-1, interleukin (IL)-6 and IL-8, in response to IL-1, IL-4, tumor-necrosis factor, or bacterial endotoxin.	Docosahexaenoic Acids	20-23	interleukin 1 alpha	Homo sapiens	173-177
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	Alginates	38-47	interleukin 1 alpha	Homo sapiens	176-185
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	mannuronic acid	60-75	interleukin 1 alpha	Homo sapiens	176-185
11859379-0	1996	Evidence of an Eicosanoid Contribution to IL-1 Induction of IL-6 in Human Articular Chondrocytes.	Eicosanoids	15-25	interleukin 1 alpha	Homo sapiens	42-46
11859379-1	1996	It has been demonstrated previously that interleukin-1 (IL-1) induces articular cartilage explants and chondrocytes in culture to produce elevated levels of inflammatory mediators such as interleukin-6 (IL-6) and prostaglandins.	Prostaglandins	213-227	interleukin 1 alpha	Homo sapiens	41-54
11859379-1	1996	It has been demonstrated previously that interleukin-1 (IL-1) induces articular cartilage explants and chondrocytes in culture to produce elevated levels of inflammatory mediators such as interleukin-6 (IL-6) and prostaglandins.	Prostaglandins	213-227	interleukin 1 alpha	Homo sapiens	56-60
11859379-3	1996	In this study we have utilized an alginate culture system in an effort to investigate a role for eicosanoids in IL-1 induction of IL-6 expression in human articular chondrocytes.	Eicosanoids	97-108	interleukin 1 alpha	Homo sapiens	112-116
11859379-4	1996	IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes.	Alginates	43-51	interleukin 1 alpha	Homo sapiens	0-4
11859379-4	1996	IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes.	Prostaglandins	96-110	interleukin 1 alpha	Homo sapiens	0-4
11859379-5	1996	Cyclo-oxygenase inhibitor, indomethacin (5 &amp;mgr;g ml(minus sign1)), was able to inhibit prostaglandin synthesis to below basal levels with no significant effect on the levels of IL-6 released by chondrocytes in response to IL-1.	Indomethacin	27-39	interleukin 1 alpha	Homo sapiens	227-231
8636247-0	1996	Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves" ophthalmopathy.	Glycosaminoglycans	88-105	interleukin 1 alpha	Homo sapiens	15-19
8636247-0	1996	Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves" ophthalmopathy.	Glycosaminoglycans	88-105	interleukin 1 alpha	Homo sapiens	53-57
8636247-0	1996	Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1-induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves" ophthalmopathy.	Glycosaminoglycans	88-105	interleukin 1 alpha	Homo sapiens	53-57
8636247-2	1996	Interleukin-1 (IL-1), produced by macrophages and fibroblasts within the diseased orbit, stimulates GAG synthesis by orbital fibroblasts.	Glycosaminoglycans	100-103	interleukin 1 alpha	Homo sapiens	0-13
8636247-2	1996	Interleukin-1 (IL-1), produced by macrophages and fibroblasts within the diseased orbit, stimulates GAG synthesis by orbital fibroblasts.	Glycosaminoglycans	100-103	interleukin 1 alpha	Homo sapiens	15-19
8636247-6	1996	The addition of IL-1 alone stimulated GAG synthesis by 73-176% (mean, 104%; P &lt; 0.05).	Glycosaminoglycans	38-41	interleukin 1 alpha	Homo sapiens	16-20
8636247-7	1996	Significant inhibition of IL-1-stimulated GAG synthesis was observed after treatment of normal fibroblasts with IL-1ra at a concentration of 5 ng/mL (12.5-fold molar excess; mean, 33%; P &lt; 0.05); essentially complete inhibition was achieved at 40 ng/mL (100-fold molar excess; mean, 86%; P &lt; 0.05).	Glycosaminoglycans	42-45	interleukin 1 alpha	Homo sapiens	26-30
8636247-9	1996	IL-1ra and sIL-1R are potent inhibitors of IL-1-induced GAG production by cultured human orbital fibroblasts.	Glycosaminoglycans	56-59	interleukin 1 alpha	Homo sapiens	0-4
8632759-0	1996	Interleukin-1 alpha-induced modulation of topoisomerase I activity and DNA damage: implications in the mechanisms of synergy with camptothecins in vitro and in vivo.	Camptothecin	130-143	interleukin 1 alpha	Homo sapiens	0-19
8632759-2	1996	We found that interleukin-1 alpha potentiated cytotoxicity of camptothecin (4-5-fold) during simultaneous drug exposure in human ovarian NIH:OVCAR-3 cancer cells in vitro.	Camptothecin	62-74	interleukin 1 alpha	Homo sapiens	14-33
8632759-3	1996	Studies indicated that IL-1 alpha significantly increased topoisomerase I-catalyzed camptothecin-induced DNA cleavable complexes in the ovarian cell line, which was not due increased intracellular camptothecin as IL-1 alpha failed to effect cellular uptake of camptothecin.	Camptothecin	84-96	interleukin 1 alpha	Homo sapiens	23-33
8632759-6	1996	Because camptothecins are active against solid tumors in vivo, combinations of IL-1 alpha with these active drugs may lead to more effective treatment of ovarian cancers in the clinic.	Camptothecin	8-21	interleukin 1 alpha	Homo sapiens	79-89
8669050-3	1996	In this study the effect von N-acetylcysteine (NAC) on the release of interleukin-1 alpha and beta (IL-1), interleukin-2 (IL-2), interferon-gamma (IFN-gamma) and tumornecrosisfactor-alpha (TNF-alpha) was assessed in an in vitro assay.	Acetylcysteine	47-50	interleukin 1 alpha	Homo sapiens	70-89
8834013-6	1996	Decreases in circulating IL-6, soluble IL-2 (sIL-2R), and TNF receptors and in synovial fluid IL-1 levels have been reported with methotrexate.	Methotrexate	130-142	interleukin 1 alpha	Homo sapiens	94-98
8557627-0	1996	Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism.	Nitric Oxide	139-151	interleukin 1 alpha	Homo sapiens	0-13
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	90-94
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	125-135
8669050-11	1996	CONCLUSION: N-acetylcysteine is capable to co-stimulate radioprotective cytokines like IL-1 alpha and IL-1 beta and to enhance IL-2 in vitro, whereas higher doses result in a suppression.	Acetylcysteine	12-28	interleukin 1 alpha	Homo sapiens	87-97
8557627-2	1996	IL-1 increases islet expression of nitric oxide (NO) synthase, and the resultant overproduction of NO participates in inhibition of insulin secretion because NO synthase inhibitors, e.g. NG-monomethyl-arginine (NMMA), prevent this inhibition.	nmma	211-215	interleukin 1 alpha	Homo sapiens	0-4
8557627-3	1996	While exploring effects of IL-1 on islet arachidonic acid metabolism, we found that IL-1 increases islet production of the 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid 12-(HETE).	Arachidonic Acid	41-57	interleukin 1 alpha	Homo sapiens	84-88
8557627-2	1996	IL-1 increases islet expression of nitric oxide (NO) synthase, and the resultant overproduction of NO participates in inhibition of insulin secretion because NO synthase inhibitors, e.g. NG-monomethyl-arginine (NMMA), prevent this inhibition.	Nitric Oxide	35-47	interleukin 1 alpha	Homo sapiens	0-4
8557627-3	1996	While exploring effects of IL-1 on islet arachidonic acid metabolism, we found that IL-1 increases islet production of the 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid 12-(HETE).	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	147-178	interleukin 1 alpha	Homo sapiens	27-31
8557627-3	1996	While exploring effects of IL-1 on islet arachidonic acid metabolism, we found that IL-1 increases islet production of the 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid 12-(HETE).	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	147-178	interleukin 1 alpha	Homo sapiens	84-88
8557627-2	1996	IL-1 increases islet expression of nitric oxide (NO) synthase, and the resultant overproduction of NO participates in inhibition of insulin secretion because NO synthase inhibitors, e.g. NG-monomethyl-arginine (NMMA), prevent this inhibition.	ng-monomethyl-arginine	187-209	interleukin 1 alpha	Homo sapiens	0-4
8557627-3	1996	While exploring effects of IL-1 on islet arachidonic acid metabolism, we found that IL-1 increases islet production of the 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid 12-(HETE).	Hydroxyeicosatetraenoic Acids	183-187	interleukin 1 alpha	Homo sapiens	84-88
8557627-7	1996	Mass spectrometric stereochemical analyses nonetheless indicate that 12-HETE produced by IL-1-treated islets consists only of the S-enantiomer and thus arises from enzyme action.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	69-76	interleukin 1 alpha	Homo sapiens	89-93
8557627-8	1996	IL-1 does enhance release of nonesterified arachidonate from islets, as measured by isotope dilution mass spectrometry, and this effect is suppressed by NMMA and mimicked by the NO-releasing compound 3-morpholinosydnonimine.	Arachidonic Acid	43-55	interleukin 1 alpha	Homo sapiens	0-4
8557627-8	1996	IL-1 does enhance release of nonesterified arachidonate from islets, as measured by isotope dilution mass spectrometry, and this effect is suppressed by NMMA and mimicked by the NO-releasing compound 3-morpholinosydnonimine.	nmma	153-157	interleukin 1 alpha	Homo sapiens	0-4
8794226-0	1996	Benzene-induced bone marrow cell depression caused by inhibition of the conversion of pre-interleukins-1alpha and -1beta to active cytokines by hydroquinone, a biological reactive metabolite of benzene.	Benzene	0-7	interleukin 1 alpha	Homo sapiens	90-120
8557627-8	1996	IL-1 does enhance release of nonesterified arachidonate from islets, as measured by isotope dilution mass spectrometry, and this effect is suppressed by NMMA and mimicked by the NO-releasing compound 3-morpholinosydnonimine.	linsidomine	200-223	interleukin 1 alpha	Homo sapiens	0-4
8557627-10	1996	IL-1 also impairs esterification of [3H8]arachidonate into islet phospholipids, and this effect is prevented by NMMA and mimicked by the mitochondrial ATP-synthase inhibitor oligomycin.	[3h8]arachidonate	36-53	interleukin 1 alpha	Homo sapiens	0-4
8557627-10	1996	IL-1 also impairs esterification of [3H8]arachidonate into islet phospholipids, and this effect is prevented by NMMA and mimicked by the mitochondrial ATP-synthase inhibitor oligomycin.	Phospholipids	65-78	interleukin 1 alpha	Homo sapiens	0-4
8557627-10	1996	IL-1 also impairs esterification of [3H8]arachidonate into islet phospholipids, and this effect is prevented by NMMA and mimicked by the mitochondrial ATP-synthase inhibitor oligomycin.	nmma	112-116	interleukin 1 alpha	Homo sapiens	0-4
8557627-10	1996	IL-1 also impairs esterification of [3H8]arachidonate into islet phospholipids, and this effect is prevented by NMMA and mimicked by the mitochondrial ATP-synthase inhibitor oligomycin.	Oligomycins	174-184	interleukin 1 alpha	Homo sapiens	0-4
8847725-15	1996	All responding patients required phenylephrine for treatment of IL-1 alpha-induced hypotension, whereas six (19%) of 31 of the nonresponding patients with nonvisceral metastases required phenylephrine (P = .0008).	Phenylephrine	33-46	interleukin 1 alpha	Homo sapiens	64-74
8847725-21	1996	IMPLICATIONS: Administration of higher doses of IL-1 alpha alone has been shown to produce hypotension in a large proportion of patients but can be given safely with phenylephrine support.	Phenylephrine	166-179	interleukin 1 alpha	Homo sapiens	48-58
8720407-10	1996	The prostaglandin E2 production was dramatically enhanced by additional interleukin-1 alpha, but decreased by the addition of tumor necrosis factor-alpha.	Dinoprostone	4-20	interleukin 1 alpha	Homo sapiens	72-91
8720407-11	1996	CONCLUSION: The results demonstrate that at the site of lumbar disc herniation, inflammatory cytokines such as interleukin-1 alpha are produced, which increases prostaglandin E2 production.	Dinoprostone	161-177	interleukin 1 alpha	Homo sapiens	111-130
8548848-6	1996	After 6 hr stimulation with IL-1 alpha suppression of E-selectin was observed with progesterone (P &lt; 0.001).	Progesterone	83-95	interleukin 1 alpha	Homo sapiens	28-38
8865862-5	1996	However, interleukin-1 (IL-1) (10 ng/mL) enhances, within two hours (+40%, p &lt; 0.05), intracellular production of hydrogen peroxide.	Hydrogen Peroxide	117-134	interleukin 1 alpha	Homo sapiens	9-28
8794226-0	1996	Benzene-induced bone marrow cell depression caused by inhibition of the conversion of pre-interleukins-1alpha and -1beta to active cytokines by hydroquinone, a biological reactive metabolite of benzene.	hydroquinone	144-156	interleukin 1 alpha	Homo sapiens	90-120
8536785-7	1996	IL-1 alpha-induced GM-CSF, IL-1 beta, IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha-induced G-CSF mRNA.	Dexamethasone	103-116	interleukin 1 alpha	Homo sapiens	0-10
8839631-3	1996	The authors compared effects of KE-758 and KE-298 on inflammatory cytokine production from human peripheral blood mononuclear cells and human umbilical vein endothelial cells (HUVEC), interleukin-1 (IL-1)-induced thymocyte proliferation (LAF) activity, adjuvant-induced arthritis in rats and lymphocyte transformation test in mice.	KE 758	32-38	interleukin 1 alpha	Homo sapiens	184-203
8839631-3	1996	The authors compared effects of KE-758 and KE-298 on inflammatory cytokine production from human peripheral blood mononuclear cells and human umbilical vein endothelial cells (HUVEC), interleukin-1 (IL-1)-induced thymocyte proliferation (LAF) activity, adjuvant-induced arthritis in rats and lymphocyte transformation test in mice.	esonarimod	43-49	interleukin 1 alpha	Homo sapiens	184-203
8772539-9	1996	Interleukin-1 (IL-1)-stimulated secretion of the inflammatory mediators, IL-6 and prostaglandin E2, was also inhibited by surfactant.	Dinoprostone	82-98	interleukin 1 alpha	Homo sapiens	0-19
11856995-6	1996	We have found that small-sized Ti particles of phagocytosable size, a commonly encountered particle species in the periprosthetic tissues of failed THAs, stimulate macrophages to secrete various mediators of bone resorption (prostaglandin E(2), interleukin-1, interleukin-6, and tumor necrosis factor-alpha from macrophages and cause bone resorption in organ culture.	Titanium	31-33	interleukin 1 alpha	Homo sapiens	245-258
8546706-0	1996	A redox-based mechanism for induction of interleukin-1 production by nitric oxide in a human colonic epithelial cell line (HT29-Cl.16E).	Nitric Oxide	69-81	interleukin 1 alpha	Homo sapiens	41-54
8704096-1	1996	We evaluate the influence of IL-4, IL-10 and TGF-beta upon the release of IL-1 alpha, tumor necrosis factor-alpha (TNF-alpha), and IL-6 by lipopolisaccharide (LPS, 1 microgram/ml) stimulated alveolar macrophages (AM).	lipopolisaccharide	139-157	interleukin 1 alpha	Homo sapiens	74-84
8704096-1	1996	We evaluate the influence of IL-4, IL-10 and TGF-beta upon the release of IL-1 alpha, tumor necrosis factor-alpha (TNF-alpha), and IL-6 by lipopolisaccharide (LPS, 1 microgram/ml) stimulated alveolar macrophages (AM).	lps	159-162	interleukin 1 alpha	Homo sapiens	74-84
8704096-2	1996	IL-4 reduced TNF-alpha release, in a dose dependent manner, to 62% and IL-1 alpha release to 42% of LPS-stimulated AM without IL-4.	lps	100-103	interleukin 1 alpha	Homo sapiens	71-81
8536785-7	1996	IL-1 alpha-induced GM-CSF, IL-1 beta, IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha-induced G-CSF mRNA.	Dexamethasone	126-139	interleukin 1 alpha	Homo sapiens	0-10
8867766-6	1996	The protein synthesis inhibitor cycloheximide abrogated the effects of IL-1 alpha, IL-1 beta and TNF-alpha on KGF gene induction, indicating that new protein synthesis is required in the process.	Cycloheximide	32-45	interleukin 1 alpha	Homo sapiens	71-81
8886801-9	1996	Vitamin E treatment significantly reduced IL-1 production after AAPH exposure.	Vitamin E	0-9	interleukin 1 alpha	Homo sapiens	42-46
8886801-9	1996	Vitamin E treatment significantly reduced IL-1 production after AAPH exposure.	2,2'-azobis(2-amidinopropane)	64-68	interleukin 1 alpha	Homo sapiens	42-46
8838968-5	1996	The effect of urinary trypsin inhibitor on the production of prostaglandin E2 (PGE2) from myometrial cultures stimulated by IL-8, IL-1 and LPS was verified.	Dinoprostone	61-77	interleukin 1 alpha	Homo sapiens	130-134
8838968-5	1996	The effect of urinary trypsin inhibitor on the production of prostaglandin E2 (PGE2) from myometrial cultures stimulated by IL-8, IL-1 and LPS was verified.	Dinoprostone	79-83	interleukin 1 alpha	Homo sapiens	130-134
8838968-9	1996	Also, urinary trypsin inhibitor could significantly inhibit the production of PGE2 in the myometrial cell cultures stimulated by IL-1 and LPS (p &lt; 0.001 and 0.0005).	Dinoprostone	78-82	interleukin 1 alpha	Homo sapiens	129-133
8867766-7	1996	Dexamethasone (10(-7) M), known to inhibit inflammatory reactions and retard wound healing, also inhibited the induction of KGF mRNA expression by IL-1 alpha, IL-1 beta and TNF-alpha.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	147-157
8718503-4	1996	From 2 to 4 months post-transplant, 67% of the recipients of unmodified marrow and 45% of the recipients of SBA-E- marrow grafts produced a normal level of IL-1.	sba-e	108-113	interleukin 1 alpha	Homo sapiens	156-160
8592071-3	1996	The rate of cell division was significantly higher than previously described for infundibula maintained in supplemented William"s E medium, and moreover did not fall over 7 d. The addition of 1 ng/ml interleukin-1 alpha (IL-1 alpha) caused hypercornification of the infundibulum similar to that seen in comedones; this could be blocked by 1000 ng/ml interleukin-1 receptor antagonist (IL-1ra).	william"s e medium	120-138	interleukin 1 alpha	Homo sapiens	200-219
8592071-3	1996	The rate of cell division was significantly higher than previously described for infundibula maintained in supplemented William"s E medium, and moreover did not fall over 7 d. The addition of 1 ng/ml interleukin-1 alpha (IL-1 alpha) caused hypercornification of the infundibulum similar to that seen in comedones; this could be blocked by 1000 ng/ml interleukin-1 receptor antagonist (IL-1ra).	william"s e medium	120-138	interleukin 1 alpha	Homo sapiens	221-231
16873161-3	1996	There was a positive correlation between concentrations of IL-1&amp;beta; and IL-6.	Adenosine Monophosphate	64-67	interleukin 1 alpha	Homo sapiens	59-63
8722494-1	1996	Prostaglandins and leukotrienes differentially regulate the production of interleukin-1 (IL-1) in monocytes.	Prostaglandins	0-14	interleukin 1 alpha	Homo sapiens	89-93
8722494-1	1996	Prostaglandins and leukotrienes differentially regulate the production of interleukin-1 (IL-1) in monocytes.	Leukotrienes	19-31	interleukin 1 alpha	Homo sapiens	89-93
8722494-10	1996	Addition of polyethylene glycol 8000 to MI-886-treated cultures eliminated the inhibitory effects of this drug, suggesting that this drug exerts its effects by promoting production of IL-1 inhibitors.	polyethylene glycol 8000	12-36	interleukin 1 alpha	Homo sapiens	184-188
8722494-10	1996	Addition of polyethylene glycol 8000 to MI-886-treated cultures eliminated the inhibitory effects of this drug, suggesting that this drug exerts its effects by promoting production of IL-1 inhibitors.	mi-886	40-46	interleukin 1 alpha	Homo sapiens	184-188
8649201-6	1996	The effects of ibuprofen on VCAM-1 expression were dose-dependent (IC50 [IL-1 alpha]: 0.5 mM; IC50 [TNF alpha]: 0.5 mM) and time-dependent with maximum responses observed after 18 h. Moreover, ibuprofen abrogated pyrogen-dependent adhesion of leukocytes to HUVEC.	Ibuprofen	15-24	interleukin 1 alpha	Homo sapiens	73-83
9390270-5	1996	The costimulatory effect of IL-1 and TNF is strongly enhanced by the calcium ionophore ionomycin.	Calcium	69-76	interleukin 1 alpha	Homo sapiens	28-40
9390270-5	1996	The costimulatory effect of IL-1 and TNF is strongly enhanced by the calcium ionophore ionomycin.	Ionomycin	87-96	interleukin 1 alpha	Homo sapiens	28-40
8910920-0	1996	Effect of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha on the intracellular fluorescein fluorescence polarization of human lung fibroblasts.	Fluorescein	103-114	interleukin 1 alpha	Homo sapiens	10-29
8910920-6	1996	The reduction in IFFP, following stimulation with the cytokines, was detected as early as 20 min after exposure to the cytokines, lasted at least 40-60 min after exposure to IL-1 alpha and IL-1 beta, and was inhibited by vinblastine, an inhibitor of the polymerization of microtubules.	Vinblastine	221-232	interleukin 1 alpha	Homo sapiens	174-184
8598481-6	1996	However, when used simultaneously, DHEA and LPS 0.2 ng/ml displayed a synergistic effect on monocyte cytotoxicity against cancerous cell lines, IL-1 secretion, reactive nitrogen intermediate release, complement receptor-1 cell-surface protein, and TNF-alpha protein to levels comparable with levels obtained using LPS 1.0 microgram/ml.	Dehydroepiandrosterone	35-39	interleukin 1 alpha	Homo sapiens	144-148
8649201-3	1996	In this study, the effects of ibuprofen on IL-1 alpha and TNF alpha-induced expression of ICAM-1, VCAM-1 and E-selectin on cultured human umbilical vein EC (HUVEC) were analyzed.	Ibuprofen	30-39	interleukin 1 alpha	Homo sapiens	43-53
8649201-5	1996	Ibuprofen was identified as a potent inhibitor of IL-1 alpha and TNF alpha-induced surface expression of VCAM-1 and a less potent inhibitor of pyrogen-induced expression of ICAM-1, whereas no effect on E-selectin was found.	Ibuprofen	0-9	interleukin 1 alpha	Homo sapiens	50-60
8805102-5	1996	Prostaglandin E2 depressed the production of IL-1 alpha, while it up-regulated the production of IL-6, TNF-alpha, and IFN-gamma.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	45-55
8742951-0	1996	Nicardipine hydrochloride suppresses DNA synthesis in human mesangial cells stimulated with recombinant human (rh) platelet-derived growth factor AA, rh interleukin-1 alpha, or rh tumor necrosis factor-alpha.	Nicardipine	0-25	interleukin 1 alpha	Homo sapiens	153-172
16764118-7	1996	The majority of these substances (TNFalpha, IL-1, IL-2, IL-3, IL-6) can stimulate the prostaglandin-biosynthesis by intrauterine tissues (amnion, chorion, decidua), some of them have antiinflammatory effects (IL-10, transforming growth factor alpha).	Prostaglandins	86-99	interleukin 1 alpha	Homo sapiens	44-48
8728354-8	1996	Recombinant IL-1, anti ICAM-1, and anti LFA-3 alone and collectively induced modest but significant increases in the secretions of 14C-labelled peptides and of IL-6 and IL-8 which were not inhibited by HC.	Carbon-14	131-134	interleukin 1 alpha	Homo sapiens	12-16
8728354-10	1996	HC inhibited the secretion of GM-CSF and LIF induced by IL-1.	Hydrocortisone	0-2	interleukin 1 alpha	Homo sapiens	56-60
8680718-9	1995	6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values.	Nitrites	393-400	interleukin 1 alpha	Homo sapiens	15-25
8548860-3	1995	The stromal macrophage, a target of benzene toxicity, is involved in hematopoietic regulation through the synthesis of several cytokines including interleukin-1, which is required for production by stromal fibroblasts of a number of cytokines required for the survival of hematopoietic progenitor cells.	Benzene	36-43	interleukin 1 alpha	Homo sapiens	147-160
8680718-7	1995	The combination of IL-1 alpha/IFN-gamma produced a highly significant (P &lt; 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective.	Nitrites	104-111	interleukin 1 alpha	Homo sapiens	19-29
8680718-8	1995	5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P &lt; 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively.	Nitrites	109-116	interleukin 1 alpha	Homo sapiens	27-37
8680718-9	1995	6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values.	Cycloheximide	331-344	interleukin 1 alpha	Homo sapiens	15-25
8903851-4	1995	The results have shown that interleukin-1 (IL-1) is a potent activator of human astrocytes and induces cytokines such as tumor necrosis factor alpha and interleukin-6, and is a potent activator of nitric oxide generation in astrocytes.	Nitric Oxide	197-209	interleukin 1 alpha	Homo sapiens	28-41
8903851-4	1995	The results have shown that interleukin-1 (IL-1) is a potent activator of human astrocytes and induces cytokines such as tumor necrosis factor alpha and interleukin-6, and is a potent activator of nitric oxide generation in astrocytes.	Nitric Oxide	197-209	interleukin 1 alpha	Homo sapiens	43-47
8903852-0	1995	Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors.	Nitric Oxide	100-112	interleukin 1 alpha	Homo sapiens	0-45
8964658-0	1995	Effect of peptide aldehydes with IL-1 beta converting enzyme inhibitory properties on IL-1 alpha and IL-1 beta production in vitro.	Aldehydes	18-27	interleukin 1 alpha	Homo sapiens	86-96
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	tripeptide K-26	4-14	interleukin 1 alpha	Homo sapiens	214-224
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	Aldehydes	15-23	interleukin 1 alpha	Homo sapiens	214-224
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	Aldehydes	59-67	interleukin 1 alpha	Homo sapiens	214-224
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	eoc-ala-tyr-val-ala-asp-h	69-94	interleukin 1 alpha	Homo sapiens	214-224
7499964-7	1995	We have found that TauCl inhibited the generation of nitric oxide, prostaglandin E2, tumor necrosis factor alpha, and interleukin-6, but TauCl slightly enhanced the release of IL-1 alpha.	N-chlorotaurine	137-142	interleukin 1 alpha	Homo sapiens	176-186
8587236-2	1995	The objective of this study was to investigate the role of cAMP in the regulation of IL-6 and IL-8 gene expression and peptide production in IL-1 stimulated human MC.	Cyclic AMP	59-63	interleukin 1 alpha	Homo sapiens	141-145
8587236-8	1995	Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6.	Cyclic AMP	24-28	interleukin 1 alpha	Homo sapiens	44-48
8587236-8	1995	Thus our data show that cAMP can potentiate IL-1 induced IL-6 production, while having no effect on IL-8 induction, and PGE2 may operate via a positive feedback loop to up-regulate IL-1 induced IL-6.	Dinoprostone	120-124	interleukin 1 alpha	Homo sapiens	181-185
8587236-9	1995	Taken together, our results demonstrate that cAMP differentially regulates IL-6 and IL-8 production in IL-1-stimulated human MC.	Cyclic AMP	45-49	interleukin 1 alpha	Homo sapiens	103-107
8834760-6	1995	TcAg also stimulated macrophages to produce interleukin-1 and could stimulate human B cells.	tcag	0-4	interleukin 1 alpha	Homo sapiens	44-57
8599808-5	1995	Oxygen radicals act as second messenger for the activation of cytokines via NF-kappaB transcription factor, they stimulate the formation of TNF-alpha, IL-1, IL-6 and influence the expression of monocyte-specific cytokines (CSF-1 and MCP-1).	Reactive Oxygen Species	0-15	interleukin 1 alpha	Homo sapiens	151-155
7487926-6	1995	These results imply that the activation of distinct MAP kinase pathways is required for the stimulation of glucose transport by IL1/anisomycin and IGF1 in KB cells, and suggest that the combined use of SB 203580 and PD 98059 is a powerful new approach to explore the roles of different MAP kinase cascades in cell regulation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	216-224	interleukin 1 alpha	Homo sapiens	128-131
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	interleukin 1 alpha	Homo sapiens	200-219
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	interleukin 1 alpha	Homo sapiens	221-231
7585518-5	1995	The response to either TNF-alpha or IL-1 alpha is synergistically enhanced by TPA.	Tetradecanoylphorbol Acetate	78-81	interleukin 1 alpha	Homo sapiens	36-46
8603935-0	1995	Appearance of interleukin 1 alpha relates DNA interstrand cross-links and cytotoxicity in cultured human keratinocytes exposed to bis-(2-chloroethyl) sulfide.	Mustard Gas	130-157	interleukin 1 alpha	Homo sapiens	14-33
8603935-1	1995	The utility of an increase in the level of interleukin 1 alpha (IL-1 alpha) as an indicator of cytotoxicity from exposure to bis-(2-chloroethyl) sulfide (BCES) was evaluated in submerged monolayer cultures of human cutaneous keratinocytes.	Mustard Gas	125-152	interleukin 1 alpha	Homo sapiens	64-74
8603935-1	1995	The utility of an increase in the level of interleukin 1 alpha (IL-1 alpha) as an indicator of cytotoxicity from exposure to bis-(2-chloroethyl) sulfide (BCES) was evaluated in submerged monolayer cultures of human cutaneous keratinocytes.	Mustard Gas	154-158	interleukin 1 alpha	Homo sapiens	64-74
8603935-8	1995	The dose-responsive increase in the interstrand cross-linking found in the DNA of cells immediately after exposure to BCES also correlated with the increase in IL-1 alpha 72 h after exposure.	Mustard Gas	118-122	interleukin 1 alpha	Homo sapiens	160-170
8603935-9	1995	These data suggest that the appearance of IL-1 alpha can be used to quantify the cytotoxicity resulting from BCES-medicated damage to cellular DNA and that degree of cross-linking in the DNA immediately after exposure to BCES is predictive of the level of cytotoxicity in an exposed culture 3 days later.	Mustard Gas	109-113	interleukin 1 alpha	Homo sapiens	42-52
8603935-9	1995	These data suggest that the appearance of IL-1 alpha can be used to quantify the cytotoxicity resulting from BCES-medicated damage to cellular DNA and that degree of cross-linking in the DNA immediately after exposure to BCES is predictive of the level of cytotoxicity in an exposed culture 3 days later.	Mustard Gas	221-225	interleukin 1 alpha	Homo sapiens	42-52
8595517-6	1995	Plasma TXB2, PGI, LTC4D4E4, and IL-6, expressed as % baseline, were significantly lower in patients receiving IL-1ra than in the placebo group (p &lt; .05), while plasma IL-1 was increased significantly.	Prostaglandins I	13-16	interleukin 1 alpha	Homo sapiens	110-114
8595517-7	1995	IL-1 may be a necessary mediator of increased circulating PGI, TXB2, LTC4D4E4, and IL-6 levels in patients with sepsis syndrome.	Prostaglandins I	58-61	interleukin 1 alpha	Homo sapiens	0-4
8595517-9	1995	The clinical significance of IL-1 in modifying circulating eicosanoid and cytokine concentrations in clinical sepsis is not clear from the data.	Eicosanoids	59-69	interleukin 1 alpha	Homo sapiens	29-33
7575485-9	1995	Calyculin A also acted synergistically with IL-1 or TNF alpha to cause a 2-fold potentiation of IL-1- or TNF alpha-induced IL-8 mRNA and peptide and RANTES mRNA expression.	calyculin A	0-11	interleukin 1 alpha	Homo sapiens	44-48
7575485-9	1995	Calyculin A also acted synergistically with IL-1 or TNF alpha to cause a 2-fold potentiation of IL-1- or TNF alpha-induced IL-8 mRNA and peptide and RANTES mRNA expression.	calyculin A	0-11	interleukin 1 alpha	Homo sapiens	96-100
7488583-5	1995	The PGE2 concentration of the culture media for 24 h was measured after the addition of recombinant human IL-1 alpha, TGF-beta 2, or b-FGF at various concentrations.	Dinoprostone	4-8	interleukin 1 alpha	Homo sapiens	106-116
7488583-7	1995	RESULTS: The PGE2 concentration of the culture media after addition of IL-1 alpha at the concentration of 100 or 500 pg/ml (1765 (768) and 3071 (1121) pg/10(4) cells) or TGF-beta 2 at the concentration of 10 or 100 ng/ml (689 (264) and 750 (189) pg/10(4) cells) was significantly increased compared with that in the controls (67 (20) pg/10(4) cells).	Dinoprostone	13-17	interleukin 1 alpha	Homo sapiens	71-81
7488583-11	1995	CONCLUSION: IL-1 and TGF-beta may participate in postoperative inflammation after cataract surgery by increasing PGE2 synthesis by residual LECs.	Dinoprostone	113-117	interleukin 1 alpha	Homo sapiens	12-16
8654078-4	1995	Significantly higher frequencies of IL-1alpha producing cells were observed in biopsies from epoxy resin (1%) allergen-affected and formaldehyde (8%) irritant affected skin.	Formaldehyde	132-144	interleukin 1 alpha	Homo sapiens	36-45
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Arachidonic Acid	18-34	interleukin 1 alpha	Homo sapiens	208-218
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	4-bromophenacyl bromide	76-97	interleukin 1 alpha	Homo sapiens	277-287
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	interleukin 1 alpha	Homo sapiens	277-287
8596125-2	1995	Simultaneously, an increase of IL-1 mRNA production could be observed in Northern blot hybridizations with a specific cDNA gene probe for human IL-1 alpha labelled with digoxigenin.	Digoxigenin	169-180	interleukin 1 alpha	Homo sapiens	31-35
8596125-2	1995	Simultaneously, an increase of IL-1 mRNA production could be observed in Northern blot hybridizations with a specific cDNA gene probe for human IL-1 alpha labelled with digoxigenin.	Digoxigenin	169-180	interleukin 1 alpha	Homo sapiens	144-154
8576649-1	1995	Oxidized low density lipoproteins (oxLDL) (0.5-50 micrograms/ml) generated from both rabbit and human LDL stimulated the production of interleukin-1 alpha (IL-1 alpha) by as much as 2- and 6-fold, respectively, as compared to native LDL after a 2-h incubation with macrophage-derived foam cells isolated from the balloon-injured arteries of cholesterol-fed rabbits.	Cholesterol	341-352	interleukin 1 alpha	Homo sapiens	135-154
8576649-1	1995	Oxidized low density lipoproteins (oxLDL) (0.5-50 micrograms/ml) generated from both rabbit and human LDL stimulated the production of interleukin-1 alpha (IL-1 alpha) by as much as 2- and 6-fold, respectively, as compared to native LDL after a 2-h incubation with macrophage-derived foam cells isolated from the balloon-injured arteries of cholesterol-fed rabbits.	Cholesterol	341-352	interleukin 1 alpha	Homo sapiens	156-166
8845742-4	1995	in the human microglia cells ammonia decreased the constitutive secretion of interleukin-6, but it enhanced the stimulated (interleukin-1 alpha, tumor necrosis factor-alpha, gamma-interferon and gamma-interferon + tumor necrosis factor-alpha) secretion of interleukin-8.	Ammonia	29-36	interleukin 1 alpha	Homo sapiens	124-172
8845742-6	1995	The magnitude of the ammonia-effect depended on the stimulating agent (lipopolysaccharide, interleukin-1 alpha, tumor necrosis factor-alpha, gamma-interferon).	Ammonia	21-28	interleukin 1 alpha	Homo sapiens	91-139
7653683-7	1995	RESULTS: CSF levels of interleukin-1 alpha decreased significantly after haloperidol withdrawal but showed no relation to clinical status.	Haloperidol	73-84	interleukin 1 alpha	Homo sapiens	23-42
7654388-9	1995	Pretreatment of HUVE and A549 monolayers with actinomycin D inhibited both IL-1 alpha-induced production of soluble chemotactic factor(s) and transcellular migration by &gt; 90%.	Dactinomycin	46-59	interleukin 1 alpha	Homo sapiens	75-85
7649115-3	1995	Recombinant human interleukin-1 alpha (IL-1 alpha) increased prostacyclin synthesis in endothelial cells by 66% and prostaglandin E2 (PGE2) synthesis in fibroblasts by 91%.	Epoprostenol	61-73	interleukin 1 alpha	Homo sapiens	18-37
7649115-3	1995	Recombinant human interleukin-1 alpha (IL-1 alpha) increased prostacyclin synthesis in endothelial cells by 66% and prostaglandin E2 (PGE2) synthesis in fibroblasts by 91%.	Epoprostenol	61-73	interleukin 1 alpha	Homo sapiens	39-49
7649115-3	1995	Recombinant human interleukin-1 alpha (IL-1 alpha) increased prostacyclin synthesis in endothelial cells by 66% and prostaglandin E2 (PGE2) synthesis in fibroblasts by 91%.	Dinoprostone	116-132	interleukin 1 alpha	Homo sapiens	18-37
7649115-3	1995	Recombinant human interleukin-1 alpha (IL-1 alpha) increased prostacyclin synthesis in endothelial cells by 66% and prostaglandin E2 (PGE2) synthesis in fibroblasts by 91%.	Dinoprostone	116-132	interleukin 1 alpha	Homo sapiens	39-49
7649115-3	1995	Recombinant human interleukin-1 alpha (IL-1 alpha) increased prostacyclin synthesis in endothelial cells by 66% and prostaglandin E2 (PGE2) synthesis in fibroblasts by 91%.	Dinoprostone	134-138	interleukin 1 alpha	Homo sapiens	18-37
7649115-4	1995	The PG response to IL-1 alpha was suppressed to about 50% by simultaneous addition of CRF in endothelial cells (75.6 +/- 6.2 vs. 159.7 +/- 14.9 ng 6-keto-PGF1 alpha/mg protein) and fibroblasts (115.5 +/- 23 vs. 233.6 +/- 42 ng PGE2/mg protein).	Dinoprostone	227-231	interleukin 1 alpha	Homo sapiens	19-29
7649115-6	1995	It is concluded that CRF suppresses IL-1 alpha-induced PG synthesis through actions on both phospholipase A2 and cyclooxygenase.	Prostaglandins	55-57	interleukin 1 alpha	Homo sapiens	36-46
7649115-7	1995	In view of the essential role of central PGE2 in IL-1 alpha-induced CRF/ACTH release, these findings suggest a novel regulatory cascade in immune-neuroendocrine interactions.	Dinoprostone	41-45	interleukin 1 alpha	Homo sapiens	49-59
7498365-0	1995	Azidothymidine and interferon-alpha in vitro effects on hematopoiesis: protective in vitro activity of IL-1 and GM-CSF.	Zidovudine	0-14	interleukin 1 alpha	Homo sapiens	103-107
8822445-0	1995	Interleukin-1 alpha and -beta modulation of luteinized human granulosa cell oestrogen and progesterone biosynthesis.	Progesterone	90-102	interleukin 1 alpha	Homo sapiens	0-19
8822445-1	1995	This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells.	Progesterone	110-122	interleukin 1 alpha	Homo sapiens	52-71
8822445-1	1995	This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells.	Progesterone	110-122	interleukin 1 alpha	Homo sapiens	73-83
8822445-1	1995	This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells.	Estradiol	128-138	interleukin 1 alpha	Homo sapiens	52-71
8822445-1	1995	This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells.	Estradiol	128-138	interleukin 1 alpha	Homo sapiens	73-83
8822445-5	1995	Our results indicate that progesterone synthesis by basal and human chorionic gonadotrophin (HCG)-stimulated granulosa cells co-cultured with white blood cells was inhibited by 5.0 ng/ml of IL-1 alpha and IL-1 beta at 48 h of culture.	Progesterone	26-38	interleukin 1 alpha	Homo sapiens	190-200
8822445-8	1995	In contrast, basal and HCG-stimulated oestradiol production by granulosa cells cultured free of white blood cells was inhibited only by IL-1 alpha.	Estradiol	38-48	interleukin 1 alpha	Homo sapiens	136-146
8822445-9	1995	IL-1 alpha at 5.0 ng/ml produced maximal inhibition of basal oestradiol (57%) and HCG-stimulated oestradiol (41%) production at 48 h of culture.	Estradiol	61-71	interleukin 1 alpha	Homo sapiens	0-10
8822445-9	1995	IL-1 alpha at 5.0 ng/ml produced maximal inhibition of basal oestradiol (57%) and HCG-stimulated oestradiol (41%) production at 48 h of culture.	Estradiol	97-107	interleukin 1 alpha	Homo sapiens	0-10
8822445-10	1995	Gonadal steroid inhibition by IL-1 alpha and IL-1 beta was not mediated through cytotoxic or antiproliferative effects on granulosa cells.	Steroids	8-15	interleukin 1 alpha	Homo sapiens	30-40
8822445-11	1995	Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies.	Steroids	105-112	interleukin 1 alpha	Homo sapiens	46-56
8822445-11	1995	Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies.	Steroids	105-112	interleukin 1 alpha	Homo sapiens	134-144
8822445-12	1995	In conclusion, IL-1 alpha directly inhibited the production of oestradiol by human ovarian granulosa cells.	Estradiol	63-73	interleukin 1 alpha	Homo sapiens	15-25
8822445-13	1995	IL-1 alpha and IL-1 beta also exerted indirect effects on steroid production via white blood cells that are usually present in granulosa cell cultures if steps are not taken to remove them.	Steroids	58-65	interleukin 1 alpha	Homo sapiens	0-10
8746788-3	1995	We previously reported that IL-1 upregulates transcription and cell surface molecules of type I IL-1R in TIG-1 cells through induction of prostaglandin (PG) E2 and cAMP accumulation.	Dinoprostone	138-159	interleukin 1 alpha	Homo sapiens	28-32
8746788-3	1995	We previously reported that IL-1 upregulates transcription and cell surface molecules of type I IL-1R in TIG-1 cells through induction of prostaglandin (PG) E2 and cAMP accumulation.	Cyclic AMP	164-168	interleukin 1 alpha	Homo sapiens	28-32
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Flavonoids	116-126	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Genistein	127-136	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Quercetin	141-150	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	bisindole alkaloids	156-175	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Staurosporine	176-189	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	staurosporine aglycone	194-200	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Tyrphostins	209-219	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	AG-879	220-225	interleukin 1 alpha	Homo sapiens	42-55
7595543-6	1995	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation.	Phorbol Esters	4-17	interleukin 1 alpha	Homo sapiens	148-161
7595543-6	1995	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation.	Tetradecanoylphorbol Acetate	18-54	interleukin 1 alpha	Homo sapiens	148-161
7595543-7	1995	Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1-induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C. We conclude that tyrosine kinase activity is essential for interleukin-1-induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved.	Phorbol Esters	22-35	interleukin 1 alpha	Homo sapiens	116-129
7595543-7	1995	Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased interleukin-1-induced interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C. We conclude that tyrosine kinase activity is essential for interleukin-1-induced interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved.	Phorbol Esters	22-35	interleukin 1 alpha	Homo sapiens	294-307
8750626-1	1995	Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) protect normal human hematopoietic progenitors from the toxicity of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	133-162	interleukin 1 alpha	Homo sapiens	0-13
8750626-1	1995	Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) protect normal human hematopoietic progenitors from the toxicity of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	133-162	interleukin 1 alpha	Homo sapiens	15-19
8750626-1	1995	Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) protect normal human hematopoietic progenitors from the toxicity of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	164-168	interleukin 1 alpha	Homo sapiens	0-13
8750626-1	1995	Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) protect normal human hematopoietic progenitors from the toxicity of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	164-168	interleukin 1 alpha	Homo sapiens	15-19
8750626-3	1995	Diethylaminobenzaldehyde (DEAB), a competitive inhibitor of ALDH-1, was shown to prevent the protective effects of IL-1 and TNF alpha.	2-(Diethylamino)benzaldehyde	0-24	interleukin 1 alpha	Homo sapiens	115-119
8750626-3	1995	Diethylaminobenzaldehyde (DEAB), a competitive inhibitor of ALDH-1, was shown to prevent the protective effects of IL-1 and TNF alpha.	DEAB	26-30	interleukin 1 alpha	Homo sapiens	115-119
8750626-12	1995	In conclusion, inhibition of the protection from 4-HC toxicity by DEAB, together with the increase in ALDH-1 expression and activity, provide strong evidence that IL-1 and TNF alpha mediate their protective action, at least partially, through ALDH-1.	DEAB	66-70	interleukin 1 alpha	Homo sapiens	163-167
8824940-0	1995	Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha.	bisbenzylisoquinoline alkaloids	22-53	interleukin 1 alpha	Homo sapiens	97-142
7579343-9	1995	In striking contrast to what was observed for IL-1 alpha, the synthetic GC dexamethasone (DXM) at a concentration of 10(-6) mol/L consistently inhibited the basal secretion of LIF/HILDA by an average of threefold and suppressed the IL-1 alpha-induced increase of the secretion of this cytokine by HUVEC.	Dexamethasone	75-88	interleukin 1 alpha	Homo sapiens	232-242
7579343-9	1995	In striking contrast to what was observed for IL-1 alpha, the synthetic GC dexamethasone (DXM) at a concentration of 10(-6) mol/L consistently inhibited the basal secretion of LIF/HILDA by an average of threefold and suppressed the IL-1 alpha-induced increase of the secretion of this cytokine by HUVEC.	Dexamethasone	90-93	interleukin 1 alpha	Homo sapiens	232-242
7579343-12	1995	Again, IL-1 alpha proved to be a very potent stimulus for the secretion of LIF/HILDA and synthetic GC such as DXM when used at a concentration of 10(-6) mol/L inhibited by an average of threefold the basal secretion of LIF/HILDA and had suppressive effect on the IL-1 alpha-induced increase of this secretion.	Dexamethasone	110-113	interleukin 1 alpha	Homo sapiens	7-17
7579343-12	1995	Again, IL-1 alpha proved to be a very potent stimulus for the secretion of LIF/HILDA and synthetic GC such as DXM when used at a concentration of 10(-6) mol/L inhibited by an average of threefold the basal secretion of LIF/HILDA and had suppressive effect on the IL-1 alpha-induced increase of this secretion.	Dexamethasone	110-113	interleukin 1 alpha	Homo sapiens	263-273
7488130-3	1995	Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory to TPA still increased their levels of WAF1 mRNA when exposed to IL-1.	Tetradecanoylphorbol Acetate	67-70	interleukin 1 alpha	Homo sapiens	189-193
7479875-10	1995	Calcium disregulation may be responsible for the effects of A beta on cytokine production, since the calcium ionophore A23187 similarly potentiated IL-1 beta-induced cytokine secretion and EGTA treatment blocked either A beta or A23187 activity.	Calcium	101-108	interleukin 1 alpha	Homo sapiens	148-157
7479875-10	1995	Calcium disregulation may be responsible for the effects of A beta on cytokine production, since the calcium ionophore A23187 similarly potentiated IL-1 beta-induced cytokine secretion and EGTA treatment blocked either A beta or A23187 activity.	Calcimycin	119-125	interleukin 1 alpha	Homo sapiens	148-157
7488114-2	1995	Dose-response studies revealed that LPS-induced IL-1 and TNF-alpha production was apparently totally suppressed in a competitive manner by a 10-fold excess of DT-5461.	DT 5461	159-166	interleukin 1 alpha	Homo sapiens	48-52
7488114-4	1995	DT-5461 suppressed IL-1 and TNF-alpha mRNA expression in LPS-activated monocytes.	Thymidine	0-2	interleukin 1 alpha	Homo sapiens	19-23
7487926-0	1995	The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells.	Deoxyglucose	104-118	interleukin 1 alpha	Homo sapiens	129-175
7487926-1	1995	The uptake of 2-deoxyglucose into KB cells was stimulated about 2-fold by interleukin-1 (IL1), anisomycin or insulin-like growth factor-1 (IGF1).	Deoxyglucose	14-28	interleukin 1 alpha	Homo sapiens	74-87
7487926-1	1995	The uptake of 2-deoxyglucose into KB cells was stimulated about 2-fold by interleukin-1 (IL1), anisomycin or insulin-like growth factor-1 (IGF1).	Deoxyglucose	14-28	interleukin 1 alpha	Homo sapiens	89-92
7487926-2	1995	Stimulation by IL1 and anisomycin was prevented by SB 203580, a specific inhibitor of the mitogen-activated protein (MAP) kinase homologue termed "re-activating kinase" [RK; also known as p38, p40 and CSBP (cytokine synthesis anti-inflammatory-drug-binding protein)], but was unaffected by PD 98059, a specific inhibitor of the activation of the classical MAP kinase pathway.	SB 203580	51-60	interleukin 1 alpha	Homo sapiens	15-18
7487926-2	1995	Stimulation by IL1 and anisomycin was prevented by SB 203580, a specific inhibitor of the mitogen-activated protein (MAP) kinase homologue termed "re-activating kinase" [RK; also known as p38, p40 and CSBP (cytokine synthesis anti-inflammatory-drug-binding protein)], but was unaffected by PD 98059, a specific inhibitor of the activation of the classical MAP kinase pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	290-298	interleukin 1 alpha	Homo sapiens	15-18
7487926-6	1995	These results imply that the activation of distinct MAP kinase pathways is required for the stimulation of glucose transport by IL1/anisomycin and IGF1 in KB cells, and suggest that the combined use of SB 203580 and PD 98059 is a powerful new approach to explore the roles of different MAP kinase cascades in cell regulation.	Glucose	107-114	interleukin 1 alpha	Homo sapiens	128-131
7579439-2	1995	IL-1 alpha and TNF alpha act in a synergistic manner to stimulate G-CSF and GM-CSF production by CDCL, resulting in an increase in CSF secretion that is 250-fold greater than that observed with either cytokine alone.	cdcl	97-101	interleukin 1 alpha	Homo sapiens	0-10
7579439-9	1995	Brief treatment of IL-1 alpha/TNF alpha-stimulated CDCL cells with cycloheximide before receptor induction reduces the synergistic increase in growth factor mRNA by 40% to 60% compared with cells not treated with CHX.	Cycloheximide	67-80	interleukin 1 alpha	Homo sapiens	19-29
7579439-9	1995	Brief treatment of IL-1 alpha/TNF alpha-stimulated CDCL cells with cycloheximide before receptor induction reduces the synergistic increase in growth factor mRNA by 40% to 60% compared with cells not treated with CHX.	Cycloheximide	213-216	interleukin 1 alpha	Homo sapiens	19-29
8595517-0	1995	Interleukin-1 mediates increased plasma levels of eicosanoids and cytokines in patients with sepsis syndrome.	Eicosanoids	50-61	interleukin 1 alpha	Homo sapiens	0-13
8595517-1	1995	The purpose of this was to study evaluate the effects of interleukin-1 (IL-1) inhibition by human recombinant IL-1 receptor antagonist (IL-1ra) on plasma prostaglandin, leukotriene, and cytokine levels in sepsis syndrome.	Prostaglandins	154-167	interleukin 1 alpha	Homo sapiens	57-70
8595517-1	1995	The purpose of this was to study evaluate the effects of interleukin-1 (IL-1) inhibition by human recombinant IL-1 receptor antagonist (IL-1ra) on plasma prostaglandin, leukotriene, and cytokine levels in sepsis syndrome.	Prostaglandins	154-167	interleukin 1 alpha	Homo sapiens	72-76
7590354-1	1995	Synthetic intronless genes, coding for human interleukin 1 alpha (IL 1 alpha) and interleukin 1 receptor antagonist (IL1ra), have been expressed efficiently in a specially designed prokaryotic vector, pGMCE (a pGEM1 derivative), where the target gene forms the second part of a two-cistron system.	pgmce	201-206	interleukin 1 alpha	Homo sapiens	45-64
7590354-1	1995	Synthetic intronless genes, coding for human interleukin 1 alpha (IL 1 alpha) and interleukin 1 receptor antagonist (IL1ra), have been expressed efficiently in a specially designed prokaryotic vector, pGMCE (a pGEM1 derivative), where the target gene forms the second part of a two-cistron system.	pgmce	201-206	interleukin 1 alpha	Homo sapiens	66-76
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Testosterone	84-96	interleukin 1 alpha	Homo sapiens	15-28
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Testosterone	84-96	interleukin 1 alpha	Homo sapiens	30-34
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Androstenedione	101-118	interleukin 1 alpha	Homo sapiens	15-28
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Androstenedione	101-118	interleukin 1 alpha	Homo sapiens	30-34
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	alpha-dihydrotestosterone	178-203	interleukin 1 alpha	Homo sapiens	30-34
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Dihydrotestosterone	205-208	interleukin 1 alpha	Homo sapiens	15-28
8526810-1	1995	The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied.	Dihydrotestosterone	205-208	interleukin 1 alpha	Homo sapiens	30-34
8526810-4	1995	There was a 1.8-fold increase in DHT synthesis (n = 7; p &lt; 0.02) and a 1.9-fold increase in 4-androstenedione in response to IL-1 (n = 7; p &lt; 0.02) (Wilcoxon signed-rank test for non-parametric, paired observations).	Androstenedione	95-112	interleukin 1 alpha	Homo sapiens	128-132
8526810-6	1995	There was a 1.7-fold increase in DHT synthesis in response to IL-1 (n = 8; p &lt; 0.01), and a 1.5-fold increase in testosterone formation from [14C]-4-androstenedione in the presence of IL-1, in six of the cell lines (n = 6; p &lt; 0.05).	Dihydrotestosterone	33-36	interleukin 1 alpha	Homo sapiens	62-66
8526810-7	1995	Both testosterone and 4-androstenedione were effective substrates in forming the potent metabolite DHT in significant amounts in response to IL-1.	Testosterone	5-17	interleukin 1 alpha	Homo sapiens	141-145
8526810-7	1995	Both testosterone and 4-androstenedione were effective substrates in forming the potent metabolite DHT in significant amounts in response to IL-1.	Androstenedione	22-39	interleukin 1 alpha	Homo sapiens	141-145
8526810-7	1995	Both testosterone and 4-androstenedione were effective substrates in forming the potent metabolite DHT in significant amounts in response to IL-1.	Dihydrotestosterone	99-102	interleukin 1 alpha	Homo sapiens	141-145
7545102-5	1995	Induction of NO formation by thyrocytes upon stimulation with IL-1 alpha + IFN-gamma was accompanied by the synthesis of tetrahydrobiopterin (BH4), an obligatory cofactor of NOS.	sapropterin	121-140	interleukin 1 alpha	Homo sapiens	62-72
7545102-5	1995	Induction of NO formation by thyrocytes upon stimulation with IL-1 alpha + IFN-gamma was accompanied by the synthesis of tetrahydrobiopterin (BH4), an obligatory cofactor of NOS.	sapropterin	142-145	interleukin 1 alpha	Homo sapiens	62-72
8567812-0	1995	Stimulation of prostaglandin (PG) F2 alpha and PGE2 release by tumour necrosis factor-alpha and interleukin-1 alpha in cultured human luteal phase endometrial cells.	Dinoprost	15-36	interleukin 1 alpha	Homo sapiens	96-115
8567812-0	1995	Stimulation of prostaglandin (PG) F2 alpha and PGE2 release by tumour necrosis factor-alpha and interleukin-1 alpha in cultured human luteal phase endometrial cells.	Dinoprostone	47-51	interleukin 1 alpha	Homo sapiens	96-115
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	Phosphatidylserines	95-113	interleukin 1 alpha	Homo sapiens	0-10
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	Phosphatidylserines	115-117	interleukin 1 alpha	Homo sapiens	0-10
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	fluorexon	190-197	interleukin 1 alpha	Homo sapiens	0-10
8576100-5	1995	On the other hand, liposomes composed of phosphatidylcholine (PC) showed no increase in permeability when incubated with IL-1 alpha, suggesting the importance of acidic phospholipids in the interaction of IL-1 alpha with the membrane.	Phosphatidylcholines	41-60	interleukin 1 alpha	Homo sapiens	205-215
8576100-5	1995	On the other hand, liposomes composed of phosphatidylcholine (PC) showed no increase in permeability when incubated with IL-1 alpha, suggesting the importance of acidic phospholipids in the interaction of IL-1 alpha with the membrane.	Phospholipids	169-182	interleukin 1 alpha	Homo sapiens	205-215
8576100-6	1995	Furthermore, permeability of liposomal membrane was markedly increased by IL-1 alpha in the presence of 1 microM calcium ions, although a permeability change was observed even in the absence of calcium ions.	Calcium	113-120	interleukin 1 alpha	Homo sapiens	74-84
8576100-7	1995	IL-1 alpha also induced the efflux of fluorescent dextran (average M(r) of 39,600), raising the possibility of translocation of IL-1 alpha through the cell membrane.	Dextrans	50-57	interleukin 1 alpha	Homo sapiens	0-10
8576100-7	1995	IL-1 alpha also induced the efflux of fluorescent dextran (average M(r) of 39,600), raising the possibility of translocation of IL-1 alpha through the cell membrane.	Dextrans	50-57	interleukin 1 alpha	Homo sapiens	128-138
7559890-0	1995	Interleukin-1-mediated stimulation of prostaglandin E production is without effect on plasminogen activator activity in human granulosa lutein cell cultures.	Prostaglandins E	38-53	interleukin 1 alpha	Homo sapiens	0-13
7672116-2	1995	Although calcium-dependent proteolytic processing of unphosphorylated pre-IL-1 alpha could be observed in cell lysates, proteolytic processing was not induced by treatment with calcium ionophore in intact cells producing the unphosphorylated pre-IL-1 alpha.	Calcium	9-16	interleukin 1 alpha	Homo sapiens	74-84
11854837-0	1995	Tyrosine Phosphorylation: Biochemical Events Involved in Cyclooxygenase II Activation by IL-1beta Interleukin-1 induced the expression of cyclooxygenase II in renal mesangial cells.	Tyrosine	0-8	interleukin 1 alpha	Homo sapiens	98-111
7677475-3	1995	METHODS: This initial study evaluated the impact of heparin-bonded CPB circuits on production of the cytokines interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-a), IL-6, and IL-8 in adults undergoing complex cardiac operations with prolonged CPB.	Heparin	52-59	interleukin 1 alpha	Homo sapiens	126-130
7544275-2	1995	IL-1 blocks human CG-induced cAMP and testosterone formation, as well as cytochrome P450 side-chain cleavage messenger RNA (mRNA) expression.	cysteinylglycine	18-20	interleukin 1 alpha	Homo sapiens	0-4
7544275-2	1995	IL-1 blocks human CG-induced cAMP and testosterone formation, as well as cytochrome P450 side-chain cleavage messenger RNA (mRNA) expression.	Cyclic AMP	29-33	interleukin 1 alpha	Homo sapiens	0-4
7544275-2	1995	IL-1 blocks human CG-induced cAMP and testosterone formation, as well as cytochrome P450 side-chain cleavage messenger RNA (mRNA) expression.	Testosterone	38-50	interleukin 1 alpha	Homo sapiens	0-4
7584121-3	1995	To inhibit IL-1 activity at the site of infection continuously, we employed a recombinant adenovirus that contained the cDNA for human IL-1 receptor antagonist protein (IL-1ra) designated as Ad.RSVIL-1ra.	rsvil-1ra	194-203	interleukin 1 alpha	Homo sapiens	11-15
7502710-7	1995	u-PA production was rapidly increased in MG63 by IL-1 alpha (10 ng/ml), whereas an effect on t-PA production was only found after a prolonged incubation and hardly any effect of IL-1 alpha on PAI-1 production was observed.	mg63	41-45	interleukin 1 alpha	Homo sapiens	49-59
8680718-10	1995	These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme.	Nitrites	57-64	interleukin 1 alpha	Homo sapiens	28-38
8680718-11	1995	8 The addition of TNF-alpha produced a significant (P &lt; 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation.	Nitrites	114-121	interleukin 1 alpha	Homo sapiens	85-95
8680718-13	1995	These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level.	Nitrites	91-98	interleukin 1 alpha	Homo sapiens	62-72
7543732-5	1995	Apigenin also inhibited IL-1 alpha-induced prostaglandin synthesis and TNF-alpha-induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine-induced gene expression.	Prostaglandins	43-56	interleukin 1 alpha	Homo sapiens	24-34
21597830-2	1995	Incubation with 100 ng/ml human recombinant IL-1 beta for 20 hours prior to a one hour exposure to L-phenylalanine mustard (L-PAM) provided significant protection of bone marrow colony forming cells when compared to bone marrow cells not exposed to IL-1.	Melphalan	99-122	interleukin 1 alpha	Homo sapiens	44-48
21597830-2	1995	Incubation with 100 ng/ml human recombinant IL-1 beta for 20 hours prior to a one hour exposure to L-phenylalanine mustard (L-PAM) provided significant protection of bone marrow colony forming cells when compared to bone marrow cells not exposed to IL-1.	Melphalan	124-129	interleukin 1 alpha	Homo sapiens	44-48
21597830-7	1995	Finally, the protection observed by IL-1 preincubation could be abrogated by incubation with 50 mu M L-buthionine sulfoximine (BSO).	Buthionine Sulfoximine	101-125	interleukin 1 alpha	Homo sapiens	36-40
21597830-7	1995	Finally, the protection observed by IL-1 preincubation could be abrogated by incubation with 50 mu M L-buthionine sulfoximine (BSO).	Buthionine Sulfoximine	127-130	interleukin 1 alpha	Homo sapiens	36-40
21597830-8	1995	This result indicates that IL-1 may increase the amount of glutathione in hematopoietic cells and be responsible for the observed protection from L-PAM.	Glutathione	59-70	interleukin 1 alpha	Homo sapiens	27-31
21597830-8	1995	This result indicates that IL-1 may increase the amount of glutathione in hematopoietic cells and be responsible for the observed protection from L-PAM.	Melphalan	146-151	interleukin 1 alpha	Homo sapiens	27-31
8542313-1	1995	Intraperitoneal injection of rat/human corticotropin-releasing factor (CRF) (40 micrograms/kg/0.2 ml of saline) resulted in a dramatic increase in specific iodine-125-labeled human interleukin-1 alpha ([125I]IL-1 alpha) binding in the male C57BL/6 mouse pituitary at 2 and 6 h after the injection although it did not affect [125I]IL-1 alpha binding in the mouse hippocampus, spleen and testis at any time after the injection.	Sodium Chloride	104-110	interleukin 1 alpha	Homo sapiens	181-200
8542313-1	1995	Intraperitoneal injection of rat/human corticotropin-releasing factor (CRF) (40 micrograms/kg/0.2 ml of saline) resulted in a dramatic increase in specific iodine-125-labeled human interleukin-1 alpha ([125I]IL-1 alpha) binding in the male C57BL/6 mouse pituitary at 2 and 6 h after the injection although it did not affect [125I]IL-1 alpha binding in the mouse hippocampus, spleen and testis at any time after the injection.	Iodine	156-162	interleukin 1 alpha	Homo sapiens	181-200
7543732-5	1995	Apigenin also inhibited IL-1 alpha-induced prostaglandin synthesis and TNF-alpha-induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine-induced gene expression.	hydroxyflavones	135-150	interleukin 1 alpha	Homo sapiens	24-34
7542635-4	1995	Our results show that a GSL containing four sugar residues (GSL-4A) induced the release of tumor necrosis factor, interleukin-6, and interleukin-1 in MNC, whereas GSL-1, containing only one glycosyl residue, was inactive.	Glycosphingolipids	24-27	interleukin 1 alpha	Homo sapiens	133-153
8580368-4	1995	Captopril dose-dependently suppressed the IL-1 beta-induced synthesis of TNF by 74% (P &lt; 0.01) and the IL-1 beta-induced synthesis of IL-1 alpha by 60% (P &lt; 0.01).	Captopril	0-9	interleukin 1 alpha	Homo sapiens	137-147
7641804-6	1995	Under the first condition, basal PGI2 production was unaffected while, in the presence of IL-1 alpha, a marked stimulation of PGI2 synthesis was observed.	Epoprostenol	126-130	interleukin 1 alpha	Homo sapiens	90-100
7641804-8	1995	Two lines of evidence indicate that PGI2 synthase is a constitutively expressed not inducible enzyme: (a) proliferating nonproducing cells when added with PGH2 produce an amount of PGI2 not different from the amount produced by cells stimulated with IL-1 alpha; (b) under this condition PGI2 synthase was immunodetectable either by immunofluorescence detected by confocal microscopy or by ELISA and, on microsomes isolated from endothelial cells, by Western blotting.	Epoprostenol	36-40	interleukin 1 alpha	Homo sapiens	250-260
8523010-6	1995	An apparent inverse relation between interleukin-1 alpha and interleukin-6 interfacial membranes of total hip arthroplasties compared with control synovial tissues suggests a complex cellular mechanism through a cytokine/prostaglandin cascade; this may regulate the observed bone resorption in aseptic loosening.	Prostaglandins	221-234	interleukin 1 alpha	Homo sapiens	37-56
8576539-4	1995	In the present study, the effects of amiprilose HCl on IL-1 activity, production and receptor distribution were investigated.	amiprilose	37-51	interleukin 1 alpha	Homo sapiens	55-59
8576539-8	1995	The results from in vitro studies demonstrated that low concentrations of amiprilose HCl (1-100 micrograms/ml) stimulated thymocyte proliferation and enhanced the proliferative response of IL-1 stimulated human synovial fibroblasts.	amiprilose	74-88	interleukin 1 alpha	Homo sapiens	189-193
7635444-2	1995	Interleukin-1 (IL-1), a microglia-derived acute phase cytokine, activates astrocytes and induces expression of the astrocyte-derived cytokine, S100 beta, which stimulates neurite growth (and thus has been implicated in neuritic plaque formation) and increases intracellular free calcium levels.	Calcium	279-286	interleukin 1 alpha	Homo sapiens	0-13
7635444-2	1995	Interleukin-1 (IL-1), a microglia-derived acute phase cytokine, activates astrocytes and induces expression of the astrocyte-derived cytokine, S100 beta, which stimulates neurite growth (and thus has been implicated in neuritic plaque formation) and increases intracellular free calcium levels.	Calcium	279-286	interleukin 1 alpha	Homo sapiens	15-19
8520508-0	1995	An interleukin 1 receptor antagonist blocks the IL-1-induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma.	Dinoprostone	97-113	interleukin 1 alpha	Homo sapiens	48-52
8546810-9	1995	Addition of TSH (1 mU/ml) produced an increase in the level of IL-1 alpha mRNA in primary TFC and HTori3 cells, at 12 and 24 h. TSH had no significant effect on the expression of IL-6 or IL-8 mRNA.	Thyrotropin	12-15	interleukin 1 alpha	Homo sapiens	63-73
8528944-0	1995	Glycosylated human recombinant interleukin-1 alpha, neo interleukin-1 alpha, with D-mannose dimer exhibits selective activities in vivo.	Mannose	84-91	interleukin 1 alpha	Homo sapiens	31-50
8528944-0	1995	Glycosylated human recombinant interleukin-1 alpha, neo interleukin-1 alpha, with D-mannose dimer exhibits selective activities in vivo.	Mannose	84-91	interleukin 1 alpha	Homo sapiens	56-75
8520508-2	1995	We show that PGE2 is produced in short-term cultures of bone marrow cells of patients with MM, concomitantly with both IL-6 and IL-1.	Dinoprostone	13-17	interleukin 1 alpha	Homo sapiens	128-132
8520508-7	1995	These results show that induction of IL-6 by IL-1 is related to PGE2 in the bone marrow of patients with MM.	Dinoprostone	64-68	interleukin 1 alpha	Homo sapiens	45-49
7638737-1	1995	BACKGROUND: Dysregulation of macrophage tumor necrosis factor (TNF) and interleukin-(IL-1) release results from repetitive lipopolysacharride (LPS) stimulation.	lipopolysacharride	123-141	interleukin 1 alpha	Homo sapiens	85-89
8520508-8	1995	Inhibition of PGE2 synthesis (as obtained with indomethacin and the IL-1RA) might be helpful to inhibit myeloma cell proliferation by reducing IL-1-induced endogenous IL-6 production not only in vitro (as demonstrated here) but also in vivo.	Dinoprostone	14-18	interleukin 1 alpha	Homo sapiens	68-72
7638737-9	1995	Addition of 8-bromo-cyclic adenosine monophosphate, H7, or nitroprusside prevented LPSp-induced augmentation of IL-1 but had no effect on inhibition of TNF release.	8-Bromo Cyclic Adenosine Monophosphate	12-50	interleukin 1 alpha	Homo sapiens	112-116
7608556-4	1995	Dexamethasone completely inhibited IL-1-induced COX-2 mRNA expression.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	35-39
7638737-9	1995	Addition of 8-bromo-cyclic adenosine monophosphate, H7, or nitroprusside prevented LPSp-induced augmentation of IL-1 but had no effect on inhibition of TNF release.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	52-54	interleukin 1 alpha	Homo sapiens	112-116
7638737-9	1995	Addition of 8-bromo-cyclic adenosine monophosphate, H7, or nitroprusside prevented LPSp-induced augmentation of IL-1 but had no effect on inhibition of TNF release.	Nitroprusside	59-72	interleukin 1 alpha	Homo sapiens	112-116
7638737-11	1995	CONCLUSIONS: Complex, independent, but incompletely understood signal transduction pathways for LPSp-induced alterations in LPSa-stimulated macrophage TNF and IL-1 release were shown.	lpsa	124-128	interleukin 1 alpha	Homo sapiens	159-163
7615528-0	1995	Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid.	Linoleic Acid	97-110	interleukin 1 alpha	Homo sapiens	0-13
7624317-4	1995	We demonstrate that collagenase expression stimulated by trypsin or cytochalasin B is regulated entirely through an autocrine cytokine, interleukin 1 alpha (IL-1 alpha).	Cytochalasin B	68-82	interleukin 1 alpha	Homo sapiens	136-155
7624317-4	1995	We demonstrate that collagenase expression stimulated by trypsin or cytochalasin B is regulated entirely through an autocrine cytokine, interleukin 1 alpha (IL-1 alpha).	Cytochalasin B	68-82	interleukin 1 alpha	Homo sapiens	157-167
7608556-7	1995	IL-1 effects were not reduced by the protein kinase C inhibitor staurosporine or by the protein kinase A inhibitor H89 but blocked by the protein tyrosine kinase inhibitor herbimycin A.	Staurosporine	64-77	interleukin 1 alpha	Homo sapiens	0-4
7608556-7	1995	IL-1 effects were not reduced by the protein kinase C inhibitor staurosporine or by the protein kinase A inhibitor H89 but blocked by the protein tyrosine kinase inhibitor herbimycin A.	herbimycin	172-184	interleukin 1 alpha	Homo sapiens	0-4
7476933-0	1995	Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.	Sulfhydryl Compounds	0-5	interleukin 1 alpha	Homo sapiens	34-38
7476933-5	1995	In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1.	Sulfhydryl Compounds	13-18	interleukin 1 alpha	Homo sapiens	145-149
7578979-0	1995	Interleukin 1 induces prostacyclin-dependent increases in cyclic AMP production and does not affect cyclic GMP production in human vascular smooth muscle cells.	Epoprostenol	22-34	interleukin 1 alpha	Homo sapiens	0-13
7476933-10	1995	Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not.	Sulfhydryl Compounds	22-27	interleukin 1 alpha	Homo sapiens	90-94
7578979-3	1995	IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively.	Cyclic AMP	13-17	interleukin 1 alpha	Homo sapiens	0-4
7622047-5	1995	Both recombinant huIL-10 and supernatants from COS cells transfected with an expression vector containing the ovIL-10 cDNA inhibited production of IL-1 and tumour necrosis factor-alpha by ov-alveolar macrophages.	ovil-10	110-117	interleukin 1 alpha	Homo sapiens	147-184
7621583-4	1995	When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli.	Dexamethasone	5-18	interleukin 1 alpha	Homo sapiens	51-61
7621583-4	1995	When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli.	Dexamethasone	5-18	interleukin 1 alpha	Homo sapiens	95-105
7621583-4	1995	When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli.	Hydrocortisone	22-36	interleukin 1 alpha	Homo sapiens	51-61
7621583-4	1995	When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli.	Hydrocortisone	22-36	interleukin 1 alpha	Homo sapiens	95-105
7621583-6	1995	In contrast, dexamethasone counteracts, in an additive way, the inhibitory effect of IL-1 alpha on regulatory complement protein factor H production by EC.	Dexamethasone	13-26	interleukin 1 alpha	Homo sapiens	85-95
7621586-8	1995	Hydrocortisone reduced IL-1 alpha to below the limit of sensitivity of the ELISA, and induced a small increase in IL-1Ra of questionable biological significance.	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	23-33
7578979-3	1995	IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively.	Epoprostenol	59-71	interleukin 1 alpha	Homo sapiens	0-4
7578979-3	1995	IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively.	Epoprostenol	73-77	interleukin 1 alpha	Homo sapiens	0-4
7578979-3	1995	IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively.	Indomethacin	111-123	interleukin 1 alpha	Homo sapiens	0-4
7578979-0	1995	Interleukin 1 induces prostacyclin-dependent increases in cyclic AMP production and does not affect cyclic GMP production in human vascular smooth muscle cells.	Cyclic AMP	58-68	interleukin 1 alpha	Homo sapiens	0-13
7578979-2	1995	In the present study, IL-1 markedly increased intracellular levels of the vasodilatory mediator, cAMP, in human saphenous and human aortic VSMC.	Cyclic AMP	97-101	interleukin 1 alpha	Homo sapiens	22-26
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	118-120	interleukin 1 alpha	Homo sapiens	31-41
7578979-3	1995	IL-1-induced cAMP was associated with a marked increase in prostacyclin (PGI2) production, and was reversed by indomethacin and tranylcypromine, inhibitors of cyclooxygenase and PGI2 synthetase respectively.	Tranylcypromine	128-143	interleukin 1 alpha	Homo sapiens	0-4
7578979-4	1995	Furthermore, PGI2, but not PGE2, was a potent inducer of cAMP production in HSVSMC, implicating a role for PGI2 in mediating IL-1-induced cAMP production.	Epoprostenol	13-17	interleukin 1 alpha	Homo sapiens	125-129
7578979-4	1995	Furthermore, PGI2, but not PGE2, was a potent inducer of cAMP production in HSVSMC, implicating a role for PGI2 in mediating IL-1-induced cAMP production.	hsvsmc	76-82	interleukin 1 alpha	Homo sapiens	125-129
7578979-4	1995	Furthermore, PGI2, but not PGE2, was a potent inducer of cAMP production in HSVSMC, implicating a role for PGI2 in mediating IL-1-induced cAMP production.	Epoprostenol	107-111	interleukin 1 alpha	Homo sapiens	125-129
7578979-4	1995	Furthermore, PGI2, but not PGE2, was a potent inducer of cAMP production in HSVSMC, implicating a role for PGI2 in mediating IL-1-induced cAMP production.	Cyclic AMP	138-142	interleukin 1 alpha	Homo sapiens	125-129
7578979-5	1995	In previous studies, IL-1 increased immunoreactive cGMP production in human saphenous VSMC through a pathway inhibitable by soluble guanylate cyclase inhibitors, methylene blue and LY83583, but not by nitric oxide (NO) synthase inhibitors, suggesting a role of NO-independent activation of soluble guanylate cyclase.	Cyclic GMP	51-55	interleukin 1 alpha	Homo sapiens	21-25
7578979-5	1995	In previous studies, IL-1 increased immunoreactive cGMP production in human saphenous VSMC through a pathway inhibitable by soluble guanylate cyclase inhibitors, methylene blue and LY83583, but not by nitric oxide (NO) synthase inhibitors, suggesting a role of NO-independent activation of soluble guanylate cyclase.	Methylene Blue	162-176	interleukin 1 alpha	Homo sapiens	21-25
7578979-5	1995	In previous studies, IL-1 increased immunoreactive cGMP production in human saphenous VSMC through a pathway inhibitable by soluble guanylate cyclase inhibitors, methylene blue and LY83583, but not by nitric oxide (NO) synthase inhibitors, suggesting a role of NO-independent activation of soluble guanylate cyclase.	6-anilino-5,8-quinolinedione	181-188	interleukin 1 alpha	Homo sapiens	21-25
7578979-5	1995	In previous studies, IL-1 increased immunoreactive cGMP production in human saphenous VSMC through a pathway inhibitable by soluble guanylate cyclase inhibitors, methylene blue and LY83583, but not by nitric oxide (NO) synthase inhibitors, suggesting a role of NO-independent activation of soluble guanylate cyclase.	Nitric Oxide	201-213	interleukin 1 alpha	Homo sapiens	21-25
7578979-7	1995	The results implicate prostacyclin-dependent cAMP production as a mediator of the vasodilatory effects of IL-1 in humans.	Epoprostenol	22-34	interleukin 1 alpha	Homo sapiens	106-110
7578979-7	1995	The results implicate prostacyclin-dependent cAMP production as a mediator of the vasodilatory effects of IL-1 in humans.	Cyclic AMP	45-49	interleukin 1 alpha	Homo sapiens	106-110
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	106-116	interleukin 1 alpha	Homo sapiens	10-29
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	106-116	interleukin 1 alpha	Homo sapiens	31-41
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	118-120	interleukin 1 alpha	Homo sapiens	10-29
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	213-215	interleukin 1 alpha	Homo sapiens	10-29
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	213-215	interleukin 1 alpha	Homo sapiens	31-41
8588070-6	1995	Coapplication of quinacrine (10 microM) and bromophenacyl bromide (100 microM), inhibitors of phospholipase A2 (PLA2), prevented the IL-1 alpha-induced increases in PGF2 alpha production.	Dinoprost	165-169	interleukin 1 alpha	Homo sapiens	133-143
7559085-3	1995	Incubation of NIM 1 cells with IL-1 alpha for 48 h increased the incorporation of 3H-thymidine (3H-TdR).	3h-thymidine	82-94	interleukin 1 alpha	Homo sapiens	31-41
7559085-3	1995	Incubation of NIM 1 cells with IL-1 alpha for 48 h increased the incorporation of 3H-thymidine (3H-TdR).	Tritium	82-84	interleukin 1 alpha	Homo sapiens	31-41
7559085-6	1995	These stimulatory effects of IL-1 alpha on both 3H-TdR incorporation and 45Ca influx were similarly inhibited by nicardipine, an inhibitor of voltage-dependent Ca2+ channels, in a concentration-dependent manner (10-1000 nM).	Tritium	48-50	interleukin 1 alpha	Homo sapiens	29-39
7559085-6	1995	These stimulatory effects of IL-1 alpha on both 3H-TdR incorporation and 45Ca influx were similarly inhibited by nicardipine, an inhibitor of voltage-dependent Ca2+ channels, in a concentration-dependent manner (10-1000 nM).	Nicardipine	113-124	interleukin 1 alpha	Homo sapiens	29-39
7612386-6	1995	These findings suggest that PP in MG had the effects of down-regulation of PBM IL-2 production and up-regulation of PBM IL-1 beta production, and that PP+pu therapy combined with PP suppresses the enhanced PBM IL-1 beta synthesis in MG patients.	Plutonium	154-156	interleukin 1 alpha	Homo sapiens	210-219
7675826-0	1995	Role of protein synthesis in interleukin 1 alpha-induced prostaglandin production in ovine astroglia.	Prostaglandins	57-70	interleukin 1 alpha	Homo sapiens	29-48
7675826-1	1995	Experiments were done to determine whether interleukin 1 alpha (IL-1 alpha) induces prostaglandin (PG) synthesis in cultured astroglia and to examine the role of enhanced cyclooxygenase 2 (COX 2) synthesis in these responses.	Prostaglandins	84-97	interleukin 1 alpha	Homo sapiens	43-62
7675826-1	1995	Experiments were done to determine whether interleukin 1 alpha (IL-1 alpha) induces prostaglandin (PG) synthesis in cultured astroglia and to examine the role of enhanced cyclooxygenase 2 (COX 2) synthesis in these responses.	Prostaglandins	84-97	interleukin 1 alpha	Homo sapiens	64-74
7675826-1	1995	Experiments were done to determine whether interleukin 1 alpha (IL-1 alpha) induces prostaglandin (PG) synthesis in cultured astroglia and to examine the role of enhanced cyclooxygenase 2 (COX 2) synthesis in these responses.	Prostaglandins	99-101	interleukin 1 alpha	Homo sapiens	64-74
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dinoprost	63-67	interleukin 1 alpha	Homo sapiens	24-34
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dinoprost	63-67	interleukin 1 alpha	Homo sapiens	102-112
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dactinomycin	118-131	interleukin 1 alpha	Homo sapiens	24-34
7615809-2	1995	At the inflammatory site, IL-1 is a potent inducer of the production of prostaglandin E2 (PGE2) and metalloproteinases on fibroblast-like cells, thus triggering tissue damage.	Dinoprostone	72-88	interleukin 1 alpha	Homo sapiens	26-30
7615809-2	1995	At the inflammatory site, IL-1 is a potent inducer of the production of prostaglandin E2 (PGE2) and metalloproteinases on fibroblast-like cells, thus triggering tissue damage.	Dinoprostone	90-94	interleukin 1 alpha	Homo sapiens	26-30
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	Dinoprost	54-58	interleukin 1 alpha	Homo sapiens	15-25
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	90-93	interleukin 1 alpha	Homo sapiens	15-25
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	Staurosporine	115-128	interleukin 1 alpha	Homo sapiens	15-25
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dactinomycin	118-131	interleukin 1 alpha	Homo sapiens	102-112
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Cycloheximide	152-165	interleukin 1 alpha	Homo sapiens	24-34
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dinoprost	220-224	interleukin 1 alpha	Homo sapiens	24-34
8588070-7	1995	Lastly, IL-1 alpha increased labeled arachidonic acid (AA) release whereas coaddition of quinacrine (10 microM) attenuated increased AA release.	Arachidonic Acid	37-53	interleukin 1 alpha	Homo sapiens	8-18
7675826-3	1995	Application of 10 ng/ml IL-1 alpha increased the production of PGF2 alpha for 2-24 h. Coincubation of IL-1 alpha with actinomycin D (1 microgram/ml) or cycloheximide (10 micrograms/ml) completely blocked the increase in PGF2 alpha.	Dinoprost	220-224	interleukin 1 alpha	Homo sapiens	102-112
8588070-8	1995	Therefore, we propose that IL-1 alpha enhances prostaglandin production by ovine astroglia via steps involving activation of PKC and increased activity of COX and PLA2.	Prostaglandins	47-60	interleukin 1 alpha	Homo sapiens	27-37
7675826-5	1995	These results indicate that longer periods than 4 h are necessary to increase COX2 protein, suggesting that proteins other than COX2 are involved in early IL-1 alpha-induced PG synthesis.	Prostaglandins	174-176	interleukin 1 alpha	Homo sapiens	155-165
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	Dinoprost	211-215	interleukin 1 alpha	Homo sapiens	15-25
8588070-6	1995	Coapplication of quinacrine (10 microM) and bromophenacyl bromide (100 microM), inhibitors of phospholipase A2 (PLA2), prevented the IL-1 alpha-induced increases in PGF2 alpha production.	Quinacrine	17-27	interleukin 1 alpha	Homo sapiens	133-143
7775626-9	1995	To a lesser extent, the combination of interleukin-1, interleukin-6, and tumor necrosis factor-alpha also counteracted the effects of dexamethasone.	Dexamethasone	134-147	interleukin 1 alpha	Homo sapiens	39-52
8588070-6	1995	Coapplication of quinacrine (10 microM) and bromophenacyl bromide (100 microM), inhibitors of phospholipase A2 (PLA2), prevented the IL-1 alpha-induced increases in PGF2 alpha production.	4-bromophenacyl bromide	44-65	interleukin 1 alpha	Homo sapiens	133-143
7539812-3	1995	The protein tyrosine kinase (PTK) inhibitors herbimycin A or genistein reduced IL-1 or LPS-induced NO release and NOS enzymatic activity.	herbimycin	45-57	interleukin 1 alpha	Homo sapiens	79-83
7539812-3	1995	The protein tyrosine kinase (PTK) inhibitors herbimycin A or genistein reduced IL-1 or LPS-induced NO release and NOS enzymatic activity.	Genistein	61-70	interleukin 1 alpha	Homo sapiens	79-83
8592902-0	1995	Influence of oestradiol-17 beta on interleukin-1 secretion by endotoxin-stimulated porcine mononuclear cells in vitro.	Estradiol	13-31	interleukin 1 alpha	Homo sapiens	35-48
8592902-2	1995	By use of this bioassay, the influence of increasing concentrations of oestradiol-17 beta on IL-1 secretion by endotoxin-stimulated porcine mononuclear cells (MNC) in vitro was studied.	Estradiol	71-89	interleukin 1 alpha	Homo sapiens	93-97
8592902-6	1995	The IL-1 secretion by the MNC, as determined by the D-10 bioassay, was significantly (P &lt; 0.01) suppressed by the highest oestradiol concentration tested (1500 pmol/l).	Estradiol	125-135	interleukin 1 alpha	Homo sapiens	4-8
8592902-7	1995	The results indicate that high physiological concentrations of oestradiol-17 beta may affect the secretion of IL-1 by porcine MNC.	Estradiol	63-81	interleukin 1 alpha	Homo sapiens	110-114
7544978-1	1995	Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide.	Ceramides	130-138	interleukin 1 alpha	Homo sapiens	61-80
7603468-5	1995	Using atomic absorption spectroscopy, we evaluated the cellular accumulation of cisplatin and the DNA platination; the results showed that IL-1 alpha increased cellular accumulation of cisplatin and DNA platination.	Cisplatin	80-89	interleukin 1 alpha	Homo sapiens	139-149
7760005-2	1995	N-t-Boc-Met-Leu-Phe, an antagonist for the FMLP receptor, inhibited the loss of IL-1 binding capacity induced by FMLP.	n-t-boc-met-leu-phe	0-19	interleukin 1 alpha	Homo sapiens	80-84
7603468-1	1995	The cytokine interleukin-1 alpha (IL-1 alpha) showed a cytostatic effect on human ovarian carcinoma cells and significantly enhanced the antiproliferative activity of cis-diamminedichloroplatinum(II) (cisplatin) toward the NIH:OVCAR-3 tumor cell line in culture.	Cisplatin	167-195	interleukin 1 alpha	Homo sapiens	13-32
7760005-12	1995	FMLP-induced release of the IL-1 decoy RII was unaffected by protein synthesis inhibitors, was blocked by certain protease inhibitors, and was mimicked by agents (the Ca++ ionophore A23187 and phorbol myristate acetate) that recapitulate elements in the signal transduction pathway of chemoattractant receptors.	Calcimycin	182-188	interleukin 1 alpha	Homo sapiens	28-32
7760005-12	1995	FMLP-induced release of the IL-1 decoy RII was unaffected by protein synthesis inhibitors, was blocked by certain protease inhibitors, and was mimicked by agents (the Ca++ ionophore A23187 and phorbol myristate acetate) that recapitulate elements in the signal transduction pathway of chemoattractant receptors.	Tetradecanoylphorbol Acetate	193-218	interleukin 1 alpha	Homo sapiens	28-32
7674242-6	1995	IL-1 induced prostaglandin E2 release was completely inhibited by the NSAID and partially inhibited by the salicylates.	Dinoprostone	13-29	interleukin 1 alpha	Homo sapiens	0-4
7674242-6	1995	IL-1 induced prostaglandin E2 release was completely inhibited by the NSAID and partially inhibited by the salicylates.	Salicylates	107-118	interleukin 1 alpha	Homo sapiens	0-4
7674242-7	1995	IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.	Ibuprofen	43-52	interleukin 1 alpha	Homo sapiens	0-4
7674242-7	1995	IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.	Ibuprofen	43-52	interleukin 1 alpha	Homo sapiens	82-86
7603468-1	1995	The cytokine interleukin-1 alpha (IL-1 alpha) showed a cytostatic effect on human ovarian carcinoma cells and significantly enhanced the antiproliferative activity of cis-diamminedichloroplatinum(II) (cisplatin) toward the NIH:OVCAR-3 tumor cell line in culture.	Cisplatin	167-195	interleukin 1 alpha	Homo sapiens	34-44
7603468-5	1995	Using atomic absorption spectroscopy, we evaluated the cellular accumulation of cisplatin and the DNA platination; the results showed that IL-1 alpha increased cellular accumulation of cisplatin and DNA platination.	Cisplatin	185-194	interleukin 1 alpha	Homo sapiens	139-149
7603468-1	1995	The cytokine interleukin-1 alpha (IL-1 alpha) showed a cytostatic effect on human ovarian carcinoma cells and significantly enhanced the antiproliferative activity of cis-diamminedichloroplatinum(II) (cisplatin) toward the NIH:OVCAR-3 tumor cell line in culture.	Cisplatin	201-210	interleukin 1 alpha	Homo sapiens	13-32
7603468-1	1995	The cytokine interleukin-1 alpha (IL-1 alpha) showed a cytostatic effect on human ovarian carcinoma cells and significantly enhanced the antiproliferative activity of cis-diamminedichloroplatinum(II) (cisplatin) toward the NIH:OVCAR-3 tumor cell line in culture.	Cisplatin	201-210	interleukin 1 alpha	Homo sapiens	34-44
7603468-7	1995	Further studies showed that IL-1 alpha reduced the removal of platinum from DNA.	Platinum	62-70	interleukin 1 alpha	Homo sapiens	28-38
7603468-8	1995	These results strongly suggest that IL-1 alpha inhibits DNA repair, and this decrease in DNA repair may explain, in part, the strong synergistic interaction between IL-1 alpha and cisplatin in NIH:OVCAR-3 cells.	Cisplatin	180-189	interleukin 1 alpha	Homo sapiens	36-46
7730639-2	1995	The 3-substituted 2-oxindole tenidap has proven anti-inflammatory actions both in vivo and in vitro, among which is the inhibition of TNF and IL-1 production by monocytes following activation by LPS.	3-substituted 2-oxindole	4-28	interleukin 1 alpha	Homo sapiens	142-146
7565643-6	1995	However, Poly I:C decreased only Zn1-stimulated release of IL-1 alpha.	Poly I-C	9-17	interleukin 1 alpha	Homo sapiens	59-69
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	140-153	interleukin 1 alpha	Homo sapiens	66-85
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	140-153	interleukin 1 alpha	Homo sapiens	87-97
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	155-159	interleukin 1 alpha	Homo sapiens	66-85
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	155-159	interleukin 1 alpha	Homo sapiens	87-97
7763262-2	1995	Both IL-1 alpha and IL-8 protein release were enhanced by treatment with ATRA and TNF-alpha after 48 h exposure.	Tretinoin	73-77	interleukin 1 alpha	Homo sapiens	5-15
7763262-3	1995	Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells.	Tretinoin	205-209	interleukin 1 alpha	Homo sapiens	12-22
7763262-3	1995	Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells.	Tretinoin	205-209	interleukin 1 alpha	Homo sapiens	137-147
7763262-3	1995	Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells.	Tretinoin	205-209	interleukin 1 alpha	Homo sapiens	137-147
7540334-0	1995	Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro.	Benzene	14-21	interleukin 1 alpha	Homo sapiens	51-64
7540334-0	1995	Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro.	hydroquinone	34-46	interleukin 1 alpha	Homo sapiens	51-64
7540334-1	1995	Decreased interleukin-1 (IL-1) production by mononuclear phagocytes has been shown to contribute to benzene myelotoxicity in animals.	Benzene	100-107	interleukin 1 alpha	Homo sapiens	10-23
7540334-1	1995	Decreased interleukin-1 (IL-1) production by mononuclear phagocytes has been shown to contribute to benzene myelotoxicity in animals.	Benzene	100-107	interleukin 1 alpha	Homo sapiens	25-29
7540334-3	1995	Fresh human blood monocytes were exposed to 0.001-10 microM hydroquinone (HQ) and assessed for their ability to release IL-1 alpha and IL-1 beta in response to a stimulation with endotoxin.	hydroquinone	60-72	interleukin 1 alpha	Homo sapiens	120-130
7537250-7	1995	The addition of exogenous tryptophan reversed the effect of combined IFN and IL-1 treatment, indicating that IDO activity induced by combined cytokine treatment was responsible for chlamydial inhibition.	Tryptophan	26-36	interleukin 1 alpha	Homo sapiens	77-81
7750577-0	1995	SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.	SB 203580	0-9	interleukin 1 alpha	Homo sapiens	105-118
7750577-3	1995	We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM), suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.	SB 203580	41-50	interleukin 1 alpha	Homo sapiens	218-231
7645988-0	1995	Stimulation by epigallocatechin gallate of interleukin-1 production by human peripheral blood mononuclear cells.	epigallocatechin gallate	15-39	interleukin 1 alpha	Homo sapiens	43-56
7645988-2	1995	The intracellular amounts of IL-1 beta and especially IL-1 alpha induced by EGCg, were significantly higher than their extracellular counterparts.	epigallocatechin gallate	76-80	interleukin 1 alpha	Homo sapiens	54-64
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	Glycine	16-19	interleukin 1 alpha	Homo sapiens	136-159
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	Lysine	20-23	interleukin 1 alpha	Homo sapiens	136-159
7745012-0	1995	Interleukin-1 stimulates prostaglandin E production by human trophoblast cells from first and third trimesters.	Prostaglandins E	25-40	interleukin 1 alpha	Homo sapiens	0-13
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	val-leu-lys-lys-arg	24-43	interleukin 1 alpha	Homo sapiens	136-159
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	Arginine	40-43	interleukin 1 alpha	Homo sapiens	136-159
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	44-59	interleukin 1 alpha	Homo sapiens	0-13
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	44-59	interleukin 1 alpha	Homo sapiens	15-19
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	61-64	interleukin 1 alpha	Homo sapiens	0-13
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	61-64	interleukin 1 alpha	Homo sapiens	15-19
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	195-198	interleukin 1 alpha	Homo sapiens	0-13
7745012-2	1995	Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown.	Prostaglandins E	195-198	interleukin 1 alpha	Homo sapiens	15-19
7745012-6	1995	IL-1 induced a 5-fold increase in PGE production, a response that was cell density, time, and dose dependent.	Prostaglandins E	34-37	interleukin 1 alpha	Homo sapiens	0-4
7745012-7	1995	IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response.	Prostaglandins E	13-16	interleukin 1 alpha	Homo sapiens	0-4
7745012-7	1995	IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response.	Prostaglandins E	13-16	interleukin 1 alpha	Homo sapiens	70-74
7745012-8	1995	Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions.	Prostaglandins E	37-40	interleukin 1 alpha	Homo sapiens	131-135
7745012-8	1995	Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions.	Prostaglandins E	37-40	interleukin 1 alpha	Homo sapiens	131-135
7745012-8	1995	Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions.	Prostaglandins E	241-244	interleukin 1 alpha	Homo sapiens	131-135
7745012-8	1995	Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions.	Prostaglandins E	241-244	interleukin 1 alpha	Homo sapiens	131-135
7745012-9	1995	Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells.	Prostaglandins E	121-124	interleukin 1 alpha	Homo sapiens	74-78
7745012-9	1995	Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells.	Prostaglandins E	121-124	interleukin 1 alpha	Homo sapiens	105-109
7745012-9	1995	Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells.	Prostaglandins E	121-124	interleukin 1 alpha	Homo sapiens	105-109
7745012-10	1995	These observations suggest a pivotal role of IL-1 in the regulation of PGE economy by trophoblast cells.	Prostaglandins E	71-74	interleukin 1 alpha	Homo sapiens	45-49
7534710-2	1995	We found a significant increase in the proportion of CD34+ cells in the PBSC fraction resistant to 25 micrograms/mL 5-FU after 7-day incubation with IL-1 plus IL-3 plus SCF as compared with the untreated fraction (p = 0.011).	Fluorouracil	116-120	interleukin 1 alpha	Homo sapiens	149-153
7535813-6	1995	Staurosporine inhibits freshly isolated T lymphocyte chemotaxis toward IL-8, whereas tyrphostin 23 inhibits chemotaxis of overnight cultured and anti-CD3-activated T lymphocytes toward IL-1 alpha.	Tyrphostins	85-95	interleukin 1 alpha	Homo sapiens	185-195
7717987-13	1995	Our results suggest that the IL1-induced phosphorylation of MAD3 on serine or threonine leads to its degradation.	Serine	68-74	interleukin 1 alpha	Homo sapiens	29-32
7717987-13	1995	Our results suggest that the IL1-induced phosphorylation of MAD3 on serine or threonine leads to its degradation.	Threonine	78-87	interleukin 1 alpha	Homo sapiens	29-32
7717991-9	1995	This 40 kDa protein may be related to the recently identified protein that becomes phosphorylated on tyrosine residues upon stimulation of the human epidermal carcinoma cell line KB by interleukin-1.	Tyrosine	101-109	interleukin 1 alpha	Homo sapiens	185-198
7534710-3	1995	We also showed that 5-FU-resistant PBSC have a greater capacity for expansion of IL-1/IL-3/SCF-responsive immature progenitors (p = 0.05), amplification of IL-3 plus GM-CSF responsive progenitors (p = 0.01), and production of committed single growth factor-responsive (granulocyte-macrophage colony-stimulating factor [GM-CSF]) precursors (p = 0.01) than the untreated PBSC.	Fluorouracil	20-24	interleukin 1 alpha	Homo sapiens	81-85
7721426-6	1995	Coculture study of vascular smooth muscle cells and endothelial cells without direct cell contact revealed that incubation for 72 hours with interleukin-1 induced high levels of nitric oxide release from cocultured vascular smooth muscle cells to the same degree as release from vascular smooth muscle cells alone.	Nitric Oxide	178-190	interleukin 1 alpha	Homo sapiens	141-154
7721426-8	1995	Furthermore, coincubation with 20 nmol/L BQ-485, an antagonist of one type of endothelin receptor (ETA), prevented the enhancement of interleukin-1-induced cytotoxicity in cocultured vascular smooth muscle cells.	BQ 485	41-47	interleukin 1 alpha	Homo sapiens	134-147
7721426-1	1995	Prolonged incubation with 1 nmol/L interleukin-1 induced high levels of nitric oxide release and cytotoxicity in vascular smooth muscle cells.	Nitric Oxide	72-84	interleukin 1 alpha	Homo sapiens	35-48
7721426-2	1995	NG-Monomethyl-L-arginine, an inhibitor of nitric oxide synthesis, inhibited interleukin-1-induced cytotoxicity at a concentration of 3 mmol/L.	omega-N-Methylarginine	0-24	interleukin 1 alpha	Homo sapiens	76-89
7721426-2	1995	NG-Monomethyl-L-arginine, an inhibitor of nitric oxide synthesis, inhibited interleukin-1-induced cytotoxicity at a concentration of 3 mmol/L.	Nitric Oxide	42-54	interleukin 1 alpha	Homo sapiens	76-89
7890376-5	1995	In contrast, whole cells of formaldehyde-treated P. granulosum and S. epidermidis significantly stimulated release of IL-1 beta by PBMCs from three donors compared with the negative control (culture medium).	Formaldehyde	28-40	interleukin 1 alpha	Homo sapiens	118-122
7789055-9	1995	These results in human "in vivo" confirm that ovarian steroids play an important role in regulating the production of IL1 and IL6 which could regulate bone resorption.	Steroids	54-62	interleukin 1 alpha	Homo sapiens	118-121
7706493-4	1995	In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone.	Dexamethasone	195-208	interleukin 1 alpha	Homo sapiens	51-55
7536243-6	1995	The suppression of lymphocyte blastogenesis in vitro by cyclosporine or prednisolone was restored by addition of interleukin (IL)-1, IL-2, IL-4, IL-5 or IL-6.	Cyclosporine	56-68	interleukin 1 alpha	Homo sapiens	113-131
7536243-6	1995	The suppression of lymphocyte blastogenesis in vitro by cyclosporine or prednisolone was restored by addition of interleukin (IL)-1, IL-2, IL-4, IL-5 or IL-6.	Prednisolone	72-84	interleukin 1 alpha	Homo sapiens	113-131
7676273-5	1995	The close relationship between sequential changes in the levels of tumour necrosis factor (TNF), Interleukin 1 and 6 (IL-1 and IL-6) in the serum, to the clinical progression of the disease from DF to DHF/DSS and then to full recovery implicates a pathogenetic role for the inflammatory cytokines.	dhf	201-204	interleukin 1 alpha	Homo sapiens	97-116
7676273-5	1995	The close relationship between sequential changes in the levels of tumour necrosis factor (TNF), Interleukin 1 and 6 (IL-1 and IL-6) in the serum, to the clinical progression of the disease from DF to DHF/DSS and then to full recovery implicates a pathogenetic role for the inflammatory cytokines.	dhf	201-204	interleukin 1 alpha	Homo sapiens	118-122
7532161-9	1995	Anti-IL-1 alpha antibody also abolished the E-selectin-inducing activity of PFA-fixed PCI.	Foscarnet	76-79	interleukin 1 alpha	Homo sapiens	5-15
7751029-4	1995	We demonstrated that PGE2, CT and 8-bromo-cAMP inhibited the LPS-induced gene activation of TNF-alpha and IL-1 alpha, and had no effect on the gene activation of IL-1 beta and IL-8.	Dinoprostone	21-25	interleukin 1 alpha	Homo sapiens	106-116
7751029-4	1995	We demonstrated that PGE2, CT and 8-bromo-cAMP inhibited the LPS-induced gene activation of TNF-alpha and IL-1 alpha, and had no effect on the gene activation of IL-1 beta and IL-8.	8-Bromo Cyclic Adenosine Monophosphate	34-46	interleukin 1 alpha	Homo sapiens	106-116
7884317-6	1995	The anti-inflammatory agent, dexamethasone, was the most potent agent in controlling the SE-mediated effects as evidenced by inhibited T cell proliferation (55%) and reduced levels of IL-1, IL-6, and IFN gamma (60% to 100%) and TNF alpha (50%).	Dexamethasone	29-42	interleukin 1 alpha	Homo sapiens	184-188
7897158-3	1995	Tenidap sodium has been demonstrated in in vitro studies to inhibit cyclooxygenase, lipoxygenase, and cytokine production (interleukin-1, interleukin-6, tumor necrosis factor-alpha).	tenidap	0-14	interleukin 1 alpha	Homo sapiens	123-136
7792282-0	1995	Cytokines in the viviparous reproduction of squamate reptiles: interleukin-1 alpha (IL-1 alpha) and IL-1 beta in placental structures of a skink.	squamate	44-52	interleukin 1 alpha	Homo sapiens	63-82
7745500-5	1995	Taken together, these results strongly suggest that mesangial cell proliferation and increased production of immune/chemical mediators and superoxide anion can be directly induced by IL-1 plus IL-6.	Superoxides	139-155	interleukin 1 alpha	Homo sapiens	183-187
7792282-0	1995	Cytokines in the viviparous reproduction of squamate reptiles: interleukin-1 alpha (IL-1 alpha) and IL-1 beta in placental structures of a skink.	squamate	44-52	interleukin 1 alpha	Homo sapiens	84-94
7535750-4	1995	Daily doses of recombinant human basic fibroblast growth factor (bFGF, 100 ng), tumor necrosis factor-alpha (TNF-alpha, 50 ng), or interleukin-1-alpha (IL-1 alpha, 50 ng) caused neovascular responses that were blocked by daily coadministration of the selective PKC inhibitor, calphostin C (4 micrograms).	calphostin C	276-288	interleukin 1 alpha	Homo sapiens	131-150
7864640-3	1995	Under these conditions IL-1-stimulated proteoglycan degradation was inhibited by bafilomycin A1 with an IC50 of &lt; 10 nM in both chondrocyte monolayers and articular cartilage explants.	bafilomycin A1	81-95	interleukin 1 alpha	Homo sapiens	23-27
7864640-5	1995	In chondrocyte monolayers, bafilomycin A1 could be added several hours after IL-1 and complete inhibition was still observed.	bafilomycin	27-38	interleukin 1 alpha	Homo sapiens	77-81
7864640-8	1995	IL-1 also stimulated the synthesis and secretion of prostromelysin by chondrocyte monolayers, however, under conditions in which IL-1 stimulated proteoglycan release was totally blocked by bafilomycin A1, there was no effect on IL-1-stimulated stromelysin secretion or stromelysin enzyme activity.	bafilomycin A1	189-203	interleukin 1 alpha	Homo sapiens	0-4
7864640-8	1995	IL-1 also stimulated the synthesis and secretion of prostromelysin by chondrocyte monolayers, however, under conditions in which IL-1 stimulated proteoglycan release was totally blocked by bafilomycin A1, there was no effect on IL-1-stimulated stromelysin secretion or stromelysin enzyme activity.	bafilomycin A1	189-203	interleukin 1 alpha	Homo sapiens	129-133
7864640-8	1995	IL-1 also stimulated the synthesis and secretion of prostromelysin by chondrocyte monolayers, however, under conditions in which IL-1 stimulated proteoglycan release was totally blocked by bafilomycin A1, there was no effect on IL-1-stimulated stromelysin secretion or stromelysin enzyme activity.	bafilomycin A1	189-203	interleukin 1 alpha	Homo sapiens	129-133
7821403-3	1995	However, sham injected and heat-inactivated interleukin-1 injected snails maintained significantly higher (approximately three-fold) levels of cercarial production compared to interleukin-1 injected snails over 8 weeks of cercarial shedding.	cercarial	143-152	interleukin 1 alpha	Homo sapiens	44-57
7821403-4	1995	Injection of interleukin-1 into schistosome-susceptible (M-line) and resistant (13-16-R1) strains of B. glabrata increased hemocyte phagocytosis of target particles and phagocytosis stimulated O2- production in both snail strains at 24 hr postexposure to the parasite.	Oxygen	193-195	interleukin 1 alpha	Homo sapiens	13-26
7822801-5	1995	Morphine but not opioid peptides interfered with activation and/or chemotaxis of the granulocytes induced by TNF-alpha, IL-1 alpha, IL-8, and FMLP (chemotactic peptide).	Morphine	0-8	interleukin 1 alpha	Homo sapiens	120-130
7532188-3	1995	Prolonged incubation with interleukin-1 (IL-1) induced large amounts of NO release and cytotoxicity in VSMC.	vsmc	103-107	interleukin 1 alpha	Homo sapiens	26-39
7532188-3	1995	Prolonged incubation with interleukin-1 (IL-1) induced large amounts of NO release and cytotoxicity in VSMC.	vsmc	103-107	interleukin 1 alpha	Homo sapiens	41-45
7532188-4	1995	NG-Monomethyl-L-arginine, an inhibitor of NO synthesis, inhibited both NO release and cytotoxicity induced by IL-1.	omega-N-Methylarginine	0-24	interleukin 1 alpha	Homo sapiens	110-114
7770069-4	1995	In order to understand the mechanisms by which IL-1 inhibits IL-6-stimulated fibrinogen transcription and translation, and since IL-1 is believed to act through PGE2 stimulation, we have studied the influence of PGE2 in IL-6 or IL-1, alone and in combination, on Fg mRNA expression (by Northern blot analysis) and the influence of PGE2, indomethacin, and arachidonic acid on Fg secretion.	Dinoprostone	161-165	interleukin 1 alpha	Homo sapiens	129-133
7538587-2	1995	When compared longterm in 60 experiments under standardized conditions, articular chondrocytes cultured in agarose exhibit variability in proteoglycan synthesis, and its suppression by interleukin 1 (IL-1), but a high reproducibility in the modulation of these effects by antirheumatic drugs.	Sepharose	107-114	interleukin 1 alpha	Homo sapiens	185-204
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	112-148	interleukin 1 alpha	Homo sapiens	202-212
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	150-153	interleukin 1 alpha	Homo sapiens	202-212
7853198-4	1995	Pretreatment with TPA for 15 min was enough to suppress the TNF-alpha-induced IL-1 alpha production.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 alpha	Homo sapiens	78-88
7853198-5	1995	Pretreatment for 15 min with other PKC activators such as aplysiatoxin or teleocidin, also inhibited the TNF-alpha-induced IL-1 alpha production.	aplysiatoxin	58-70	interleukin 1 alpha	Homo sapiens	123-133
7853198-5	1995	Pretreatment for 15 min with other PKC activators such as aplysiatoxin or teleocidin, also inhibited the TNF-alpha-induced IL-1 alpha production.	teleocidins	74-84	interleukin 1 alpha	Homo sapiens	123-133
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	146-149	interleukin 1 alpha	Homo sapiens	31-41
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	aplysiatoxin	151-163	interleukin 1 alpha	Homo sapiens	31-41
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	teleocidins	167-177	interleukin 1 alpha	Homo sapiens	31-41
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 alpha	Homo sapiens	66-76
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	teleocidins	186-196	interleukin 1 alpha	Homo sapiens	66-76
7846628-4	1995	We hypothesize that lipopolysaccharide stimulation of plasma membrane L-arginine transport is mediated via an autocrine cytokine loop involving TNF and IL-1.	Arginine	70-80	interleukin 1 alpha	Homo sapiens	152-156
7846628-7	1995	RESULTS: Lipopolysaccharide, IL-1, and TNF all increased both Na+-dependent and Na+-independent carrier-mediated L-arginine transport in a fashion that was both time and dose dependent.	Arginine	113-123	interleukin 1 alpha	Homo sapiens	29-33
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	53-63	interleukin 1 alpha	Homo sapiens	115-119
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	55-63	interleukin 1 alpha	Homo sapiens	115-119
7846628-12	1995	Furthermore, lipopolysaccharide stimulation of arginine transport is mediated in part through an autocrine mechanism involving IL-1 and TNF.	Arginine	47-55	interleukin 1 alpha	Homo sapiens	127-131
7770069-4	1995	In order to understand the mechanisms by which IL-1 inhibits IL-6-stimulated fibrinogen transcription and translation, and since IL-1 is believed to act through PGE2 stimulation, we have studied the influence of PGE2 in IL-6 or IL-1, alone and in combination, on Fg mRNA expression (by Northern blot analysis) and the influence of PGE2, indomethacin, and arachidonic acid on Fg secretion.	Dinoprostone	161-165	interleukin 1 alpha	Homo sapiens	129-133
7770069-5	1995	Moreover, since human recombinant interleukin-1 receptor antagonist (hrIL-1ra) is a strong inhibitor of IL-1 induced IL-1 transcription and translation and has an inhibitory effect on PGE2, we have studied the effects of IL-1ra on the down-regulation of IL-6 stimulated fibrinogen by IL-1, using an Fg ELISA method.	Dinoprostone	184-188	interleukin 1 alpha	Homo sapiens	34-47
7893261-8	1995	It is presented here that therapeutic concentrations of ibuprofen induced significant higher amounts of mRNA for interleukin-1 in human monocytes compared to untreated cells.	Ibuprofen	56-65	interleukin 1 alpha	Homo sapiens	113-126
8744695-0	1995	Influence of gold salts treatment on the serum concentration of IL-1 and IL-2 in patients with rheumatoid arthritis.	gold salts	13-23	interleukin 1 alpha	Homo sapiens	64-68
8534691-4	1995	Synthesis of hyaluronic acid was similar in all three groups, but after stimulation with Il-1 the cells exposed to the dialysates produced more hyaluronic acid.	Hyaluronic Acid	144-159	interleukin 1 alpha	Homo sapiens	89-93
8521084-5	1995	However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved: how and at which subcellular level, do the cells produce these reactive oxygen intermediates that will contribute to NF kappa B activation in response to IL-1 or TNF-alpha?	Oxygen	207-213	interleukin 1 alpha	Homo sapiens	289-293
7697373-0	1995	Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin 1 alpha.	Prostaglandins	19-32	interleukin 1 alpha	Homo sapiens	73-92
7697373-1	1995	We examined effects of interleukin 1 alpha (IL-1 alpha) on prostaglandin production in piglet cultured astroglia.	Prostaglandins	59-72	interleukin 1 alpha	Homo sapiens	23-42
7697373-1	1995	We examined effects of interleukin 1 alpha (IL-1 alpha) on prostaglandin production in piglet cultured astroglia.	Prostaglandins	59-72	interleukin 1 alpha	Homo sapiens	44-54
7697373-5	1995	Only small amounts of 6-keto-PGF 1 alpha or PGE2 were detected in medium under baseline conditions or in the presence of IL-1 alpha.	6-keto-pgf	22-32	interleukin 1 alpha	Homo sapiens	121-131
7697373-5	1995	Only small amounts of 6-keto-PGF 1 alpha or PGE2 were detected in medium under baseline conditions or in the presence of IL-1 alpha.	Dinoprostone	44-48	interleukin 1 alpha	Homo sapiens	121-131
7697373-8	1995	We conclude that IL-1 alpha causes a rapid increase in prostaglandin production by astroglia, and this process involves a step requiring continued or increased protein synthesis.	Prostaglandins	55-68	interleukin 1 alpha	Homo sapiens	17-27
7497600-5	1995	The inhibitory effects of r-verapamil and anti-IL1 serum were additive, suggesting that the antiproliferative effect of r-verapamil does not depend solely on inhibition of IL1-mediated effects.	Verapamil	120-131	interleukin 1 alpha	Homo sapiens	47-50
7821878-0	1995	Effects of contact sensitizers neomycin sulfate, benzocaine and 2,4-dinitrobenzene 1-sulfonate, sodium salt on viability, membrane integrity and IL-1 alpha mRNA expression of cultured normal human keratinocytes.	2,4-dinitrobenzene 1-sulfonate	64-94	interleukin 1 alpha	Homo sapiens	145-155
7497600-7	1995	Thus, although inhibition of IL1 effects may contribute in certain patients to the antiproliferative effect of r-verapamil, mechanisms other than IL1 inhibition seem to be more important in mediating the effects of r-verapamil.	Verapamil	111-122	interleukin 1 alpha	Homo sapiens	29-32
7821878-5	1995	The effects of the three sensitizers on IL-1 alpha mRNA expression were varied; neomycin sulfate caused a dose-dependent induction of IL-1 alpha mRNA, benzocaine did not significantly affect its signal, and DNBS suppressed IL-1 alpha gene expression.	Neomycin	80-96	interleukin 1 alpha	Homo sapiens	40-50
7821878-5	1995	The effects of the three sensitizers on IL-1 alpha mRNA expression were varied; neomycin sulfate caused a dose-dependent induction of IL-1 alpha mRNA, benzocaine did not significantly affect its signal, and DNBS suppressed IL-1 alpha gene expression.	Neomycin	80-96	interleukin 1 alpha	Homo sapiens	134-144
7821878-5	1995	The effects of the three sensitizers on IL-1 alpha mRNA expression were varied; neomycin sulfate caused a dose-dependent induction of IL-1 alpha mRNA, benzocaine did not significantly affect its signal, and DNBS suppressed IL-1 alpha gene expression.	Neomycin	80-96	interleukin 1 alpha	Homo sapiens	134-144
8562975-11	1995	These levels dropped after megestrol acetate treatment with a statistically significant decrease for interleukin-1 alpha and beta and tumor necrosis factor-alpha.	Megestrol Acetate	27-44	interleukin 1 alpha	Homo sapiens	101-120
7476567-1	1995	Previous findings provided evidence that bacterial lipopolysaccharide (LPS)-activated human monocytes are able to upregulate autologous polymorphonuclear (PMN) phagocytic ability via cell-to-cell contact mechanisms mediated by membrane (m)-associated cytokines (CKs), such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-6 and IL-8.	bacterial lipopolysaccharide	41-69	interleukin 1 alpha	Homo sapiens	312-336
7747636-2	1995	We previously reported that IL-1 inhibits PDGF-AA-induced biological activities including PDGF-AA-induced tyrosyl phosphorylation.	cyclo(tyrosyl-tyrosyl)	106-113	interleukin 1 alpha	Homo sapiens	28-32
7566325-11	1995	A disturbed profile synthesis of cytokines which induce differentiation and proliferation of the osteoclasts and which modulate the osteoblastic proliferation and function (IL-1, IL-6, TNF-alpha, GM-CSF...) may play a role in the bone loss of calcium stone formers but further studies are necessary to precise its transient or permanent involvement in their bone disease.	Calcium	243-250	interleukin 1 alpha	Homo sapiens	173-177
7566325-13	1995	This excess of calcitriol synthesis may be secondary either to monocyte increased synthesis of IL-1 which stimulates the renal 1 alpha-hydroxylase by the mean of an increased PGE2 synthesis or to the relative hypophosphatemia of the calcium stone formers comparatively to healthy controls.	Calcitriol	15-25	interleukin 1 alpha	Homo sapiens	95-99
7566325-13	1995	This excess of calcitriol synthesis may be secondary either to monocyte increased synthesis of IL-1 which stimulates the renal 1 alpha-hydroxylase by the mean of an increased PGE2 synthesis or to the relative hypophosphatemia of the calcium stone formers comparatively to healthy controls.	Dinoprostone	175-179	interleukin 1 alpha	Homo sapiens	95-99
7566582-7	1995	The exposure of MC to TNF alpha or to a lesser extent IL-1 alpha or LPS reduced their fibrinolytic activity by decreasing t-PA production and increasing PAI-1 synthesis.	Methylcholanthrene	16-18	interleukin 1 alpha	Homo sapiens	54-64
7571901-10	1995	The local cervical activation of interleukins (IL 1, 6, 8) caused by cervical infections stimulate the prostaglandin synthesis and cervical maturity.	Prostaglandins	103-116	interleukin 1 alpha	Homo sapiens	47-57
7749254-2	1995	The fall in serum iron and zinc, and rise in serum copper, are brought about by changes in the concentration of specific tissue proteins controlled by cytokines, especially interleukin 1, tumor necrosis factor, and interleukin 6.	Copper	51-57	interleukin 1 alpha	Homo sapiens	173-209
7786524-8	1995	HC (5 micrograms/ml), 1,25(OH)2D3 (10(-6) M) and MC903 (10(-6) M), but not CsA (5 micrograms/ml), inhibited IL-1 alpha production by HSC-1 cells stimulated with 100 U/ml of rIFN-gamma.	Hydrocortisone	0-2	interleukin 1 alpha	Homo sapiens	108-118
7786524-8	1995	HC (5 micrograms/ml), 1,25(OH)2D3 (10(-6) M) and MC903 (10(-6) M), but not CsA (5 micrograms/ml), inhibited IL-1 alpha production by HSC-1 cells stimulated with 100 U/ml of rIFN-gamma.	Calcitriol	22-33	interleukin 1 alpha	Homo sapiens	108-118
7699295-7	1995	The production of prostaglandin E2 in vitro was dramatically increased by the addition of IL-1 alpha and decreased by the addition of TNF-alpha.	Dinoprostone	18-34	interleukin 1 alpha	Homo sapiens	90-100
7699295-10	1995	Based on these findings, it was suggested that inflammatory cytokines, such as IL-1 alpha, are produced in herniated tissue, which increased prostaglandin E2 production and caused in sciatic pain.	Dinoprostone	141-157	interleukin 1 alpha	Homo sapiens	79-89
7777653-5	1995	The 5-HT1A agonist, 8-OH-DPAT, was able to attenuate the adrenocortical responses to acoustic stimulation, conditioned fear, IL-1 alpha, and cocaine administration, with ipsapirone also being effective in reducing the responses to acoustic stimulation and cocaine injection.	8-Hydroxy-2-(di-n-propylamino)tetralin	20-29	interleukin 1 alpha	Homo sapiens	125-135
7777653-5	1995	The 5-HT1A agonist, 8-OH-DPAT, was able to attenuate the adrenocortical responses to acoustic stimulation, conditioned fear, IL-1 alpha, and cocaine administration, with ipsapirone also being effective in reducing the responses to acoustic stimulation and cocaine injection.	ipsapirone	170-180	interleukin 1 alpha	Homo sapiens	125-135
7777653-6	1995	The 5-HT2 antagonist, ketanserin was able to reduce the adrenocortical response in the conditioned fear paradigm and the response to IL-1 alpha injection.	Ketanserin	22-32	interleukin 1 alpha	Homo sapiens	133-143
7481481-10	1995	With intermediate doses of prednisone (20-45 mg), we observed the largest improvement in IL-2 production and in IL-1 production upon LPS stimulation.	Prednisone	27-37	interleukin 1 alpha	Homo sapiens	112-116
7481481-11	1995	Higher doses of prednisone reduced also the spontaneous production of IL-1 and resulted in an increase in the expression of CD25+ cells.	Prednisone	16-26	interleukin 1 alpha	Homo sapiens	70-74
7481481-12	1995	The addition of low doses of cytotoxic drugs (oral cyclophosphamide or azathioprine) resulted in an improvement in the capacity to absorb IL-2 and a reduction in spontaneous IL-1 production.	Cyclophosphamide	51-67	interleukin 1 alpha	Homo sapiens	174-178
7481481-12	1995	The addition of low doses of cytotoxic drugs (oral cyclophosphamide or azathioprine) resulted in an improvement in the capacity to absorb IL-2 and a reduction in spontaneous IL-1 production.	Azathioprine	71-83	interleukin 1 alpha	Homo sapiens	174-178
7810657-2	1994	IL-1 dose dependently increased tritiated thymidine uptake in confluent Caco-2 monolayers fed complete growth medium.	tritiated	32-41	interleukin 1 alpha	Homo sapiens	0-4
7527398-4	1994	Ceramide has been proposed as an intracellular mediator of IL-1 action, but C2-ceramide or sphingosine stimulated predominantly MBP-specific kinase activity in fibroblasts and had no effect in HepG2 cells.	Ceramides	0-8	interleukin 1 alpha	Homo sapiens	59-63
7527398-7	1994	The major peak of IL-1-stimulated HepG2 Thr669 kinase activity co-chromatographed on Mono Q and phenyl-Superose with immunodetectable p54 MAP kinase.	Mono Q	85-91	interleukin 1 alpha	Homo sapiens	18-22
7527398-7	1994	The major peak of IL-1-stimulated HepG2 Thr669 kinase activity co-chromatographed on Mono Q and phenyl-Superose with immunodetectable p54 MAP kinase.	phenyl-superose	96-111	interleukin 1 alpha	Homo sapiens	18-22
7994038-9	1994	However, PBMC treated with D-mannose before fixation resulted in a loss of activity; this loss of activity was associated with release of IL-1 alpha, not IL-1 beta, into the supernatant.	Mannose	27-36	interleukin 1 alpha	Homo sapiens	138-148
7997261-1	1994	Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds.	pyridinyl-imidazole	119-138	interleukin 1 alpha	Homo sapiens	14-54
7994038-9	1994	However, PBMC treated with D-mannose before fixation resulted in a loss of activity; this loss of activity was associated with release of IL-1 alpha, not IL-1 beta, into the supernatant.	PBMC	9-13	interleukin 1 alpha	Homo sapiens	138-148
7810657-2	1994	IL-1 dose dependently increased tritiated thymidine uptake in confluent Caco-2 monolayers fed complete growth medium.	Thymidine	42-51	interleukin 1 alpha	Homo sapiens	0-4
7714166-1	1994	Interleukin-1 (IL-1) has been reported previously to inhibit the in-vitro decidualization of human endometrial stromal cells as assessed by progesterone-induced prolactin production and morphological transformation.	Progesterone	140-152	interleukin 1 alpha	Homo sapiens	15-19
7805742-1	1994	It has been shown that production of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by endothelial cells (EC) stimulated with tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 alpha requires the synthesis of new proteins and is regulated by anti-proteinases.	Platelet Activating Factor	65-68	interleukin 1 alpha	Homo sapiens	198-222
7805742-1	1994	It has been shown that production of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by endothelial cells (EC) stimulated with tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 alpha requires the synthesis of new proteins and is regulated by anti-proteinases.	Platelet Activating Factor	70-116	interleukin 1 alpha	Homo sapiens	198-222
7805742-2	1994	Here, we demonstrate that TNF-alpha and IL-1 alpha induce the expression by EC of a 34-kDa diisopropyl fluorophosphate-binding protein immunoprecipitated by an anti-human elastase antibody.	Isoflurophate	91-118	interleukin 1 alpha	Homo sapiens	40-50
7805742-6	1994	These results indicate that TNF-alpha and IL-1 alpha stimulate the production of a serine protease which is critical in the activation of enzymes involved in PAF synthesis, suggesting the potential involvement of this mechanism in the regulation of EC functions.	Platelet Activating Factor	158-161	interleukin 1 alpha	Homo sapiens	42-52
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	interleukin 1 alpha	Homo sapiens	193-212
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	interleukin 1 alpha	Homo sapiens	214-224
7714166-1	1994	Interleukin-1 (IL-1) has been reported previously to inhibit the in-vitro decidualization of human endometrial stromal cells as assessed by progesterone-induced prolactin production and morphological transformation.	Progesterone	140-152	interleukin 1 alpha	Homo sapiens	0-13
7714166-5	1994	TNF alpha and IL-1 significantly suppressed cAMP-stimulated prolactin production by endometrial stromal cells.	Cyclic AMP	44-48	interleukin 1 alpha	Homo sapiens	14-18
7714166-7	1994	These results indicated that TNF alpha and IL-1 suppress both progesterone-induced and cAMP-mediated prolactin production in endometrial stromal cells, and that this inhibition was not attributable to direct effects on progesterone metabolism or related to Ca(2+)-mediated signal transduction.	Progesterone	62-74	interleukin 1 alpha	Homo sapiens	43-47
7714166-7	1994	These results indicated that TNF alpha and IL-1 suppress both progesterone-induced and cAMP-mediated prolactin production in endometrial stromal cells, and that this inhibition was not attributable to direct effects on progesterone metabolism or related to Ca(2+)-mediated signal transduction.	Cyclic AMP	87-91	interleukin 1 alpha	Homo sapiens	43-47
7989466-7	1994	ET production was also stimulated by transforming growth factor-beta 1 (2, 5 &amp; 10 ng/mL) and IL-1 alpha (10 &amp; 100 IU/mL) under serum-free conditions but always to a lesser extent than stimulation by serum.	Adenosine Monophosphate	113-116	interleukin 1 alpha	Homo sapiens	97-107
7890801-7	1994	Cytokines such as IFN alpha, IFN gamma, G-CSF, TNF alpha, IL-1, and IL-4 markedly potentiate the differentiation-inducing effect of retinoids.	Retinoids	132-141	interleukin 1 alpha	Homo sapiens	58-62
7886628-10	1994	Only the PKC inhibitor H-7 reduced the augmentation that IL1 produces on CRF synthesis.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	23-26	interleukin 1 alpha	Homo sapiens	57-60
7808427-7	1994	IL-1 failed to phosphorylate Hsp27 when cells had been previously deactivated with tyrosine kinase inhibitors such as genistein.	Genistein	118-127	interleukin 1 alpha	Homo sapiens	0-4
11550712-4	1994	In the present study we compared the effect of IL-1, LPS and protein kinase C (PKC) activators (PMA), mezerein, phorbol dibutyrate on PGE2 synthesis and PLD activity in articular chondrocytes.	Dinoprostone	134-138	interleukin 1 alpha	Homo sapiens	47-51
11550712-5	1994	Although IL-1, LPS and PKC activators stimulate PGE2 synthesis, only the PKC activators stimulated PLD activity.	Dinoprostone	48-52	interleukin 1 alpha	Homo sapiens	9-13
7522684-5	1994	Furthermore, there is now evidence that the thionamides interfere with thyrocyte expression of Class I antigen, interleukin-1, interleukin-6, prostaglandin E2, and heat shock protein.	thionamides	44-55	interleukin 1 alpha	Homo sapiens	95-125
7957239-1	1994	Treatment of human synovial cells with interleukin-1 (IL-1) results in a large increase in the production of prostaglandin E2 (PGE2), a function in which the activation of phospholipase A2 (PLA2) is a key step.	Dinoprostone	109-125	interleukin 1 alpha	Homo sapiens	54-58
7957239-1	1994	Treatment of human synovial cells with interleukin-1 (IL-1) results in a large increase in the production of prostaglandin E2 (PGE2), a function in which the activation of phospholipase A2 (PLA2) is a key step.	Dinoprostone	127-131	interleukin 1 alpha	Homo sapiens	39-52
7957239-1	1994	Treatment of human synovial cells with interleukin-1 (IL-1) results in a large increase in the production of prostaglandin E2 (PGE2), a function in which the activation of phospholipase A2 (PLA2) is a key step.	Dinoprostone	127-131	interleukin 1 alpha	Homo sapiens	54-58
7957239-2	1994	In order to identify the enzymes that are linked to IL-1-mediated arachidonate availability and subsequent PGE2 production, we have investigated the changes in gene expression of the 85-kDa cytosolic PLA2 (cPLA2), the 14-kDa secretory PLA2 (sPLA2) and the two forms of cyclooxygenase in human synoviocytes after stimulation with recombinant IL-1 beta.	Arachidonic Acid	66-78	interleukin 1 alpha	Homo sapiens	52-56
7957239-3	1994	Northern-blot analysis revealed that both cPLA2 and cyclooxygenase-2 mRNA were progressively upregulated upon exposure to IL-1 for 5 hours and the glucocorticoid, dexamethasone, blocked the increased expression of these two genes.	Dexamethasone	163-176	interleukin 1 alpha	Homo sapiens	122-126
7957239-4	1994	In contrast, IL-1-induced sPLA2 gene expression determined in the same cell samples was weak and most often rapid, and dexamethasone further stimulated it.	Dexamethasone	119-132	interleukin 1 alpha	Homo sapiens	13-17
7957239-7	1994	Our data suggest that the IL-1-induced production of PGE2 in human synoviocytes can be attributed to the stimulation of both cPLA2 and cyclooxygenase-2.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	26-30
7979221-0	1994	Cytokine expression in the muscle of HIV-infected patients: evidence for interleukin-1 alpha accumulation in mitochondria of AZT fibers.	Zidovudine	125-128	interleukin 1 alpha	Homo sapiens	73-92
7979221-6	1994	Immunoelectron microscopy showed that interleukin-1 alpha was mainly bound to mitochondrial membranes in AZT fibers.	Zidovudine	105-108	interleukin 1 alpha	Homo sapiens	38-57
7536063-4	1994	Special interest was focused on prostaglandin synthesis, since indomethacin, an inhibitor of prostaglandin synthesis, partly inhibits IL-1-induced bone resorption.	Prostaglandins	32-45	interleukin 1 alpha	Homo sapiens	134-138
7536063-4	1994	Special interest was focused on prostaglandin synthesis, since indomethacin, an inhibitor of prostaglandin synthesis, partly inhibits IL-1-induced bone resorption.	Indomethacin	63-75	interleukin 1 alpha	Homo sapiens	134-138
7536063-4	1994	Special interest was focused on prostaglandin synthesis, since indomethacin, an inhibitor of prostaglandin synthesis, partly inhibits IL-1-induced bone resorption.	Prostaglandins	93-106	interleukin 1 alpha	Homo sapiens	134-138
7927949-2	1994	Exposure of these cells to IL-1 alpha decreased basal cell proliferation by half and markedly reduced the mitogenic action of 17 beta-estradiol (E2), the half-maximal inhibitory effect being exerted at 1.5 pM.	Estradiol	126-143	interleukin 1 alpha	Homo sapiens	27-37
7927949-4	1994	The antiproliferative effect of IL-1 alpha was additive to the inhibition of cell proliferation caused by dihydrotestosterone (DHT) or the glucocorticoid dexamethasone (DEX).	Dihydrotestosterone	106-125	interleukin 1 alpha	Homo sapiens	32-42
7927949-4	1994	The antiproliferative effect of IL-1 alpha was additive to the inhibition of cell proliferation caused by dihydrotestosterone (DHT) or the glucocorticoid dexamethasone (DEX).	Dihydrotestosterone	127-130	interleukin 1 alpha	Homo sapiens	32-42
7927949-4	1994	The antiproliferative effect of IL-1 alpha was additive to the inhibition of cell proliferation caused by dihydrotestosterone (DHT) or the glucocorticoid dexamethasone (DEX).	Dexamethasone	154-167	interleukin 1 alpha	Homo sapiens	32-42
7927949-4	1994	The antiproliferative effect of IL-1 alpha was additive to the inhibition of cell proliferation caused by dihydrotestosterone (DHT) or the glucocorticoid dexamethasone (DEX).	Dexamethasone	169-172	interleukin 1 alpha	Homo sapiens	32-42
7927949-5	1994	In parallel, IL-1 alpha-induced stimulation of apo-D and GCDFP-15 secretion was additive to that exerted by DHT or DEX.	Dihydrotestosterone	108-111	interleukin 1 alpha	Homo sapiens	13-23
7980528-3	1994	Here, we provide evidence that treatment of endothelial cells with the anti-inflammatory agent indomethacin abolished oxidized LDL as well as interleukin 1- and lipopolysaccharide-stimulated U937 adhesion.	Indomethacin	95-107	interleukin 1 alpha	Homo sapiens	142-155
7926002-5	1994	These data suggest that interleukin-1 suppresses synthesis of the cartilaginous matrix through more than one mechanism, at least one of which is dependent upon the production of nitric oxide.	Nitric Oxide	178-190	interleukin 1 alpha	Homo sapiens	24-37
7883398-3	1994	The latter change probably reflects stronger binding, consequent upon increased expression of p70-75 receptors for IL-2, and changes in the distribution or activity of target cells; IL-1 secretion may enhance the responsiveness of peripheral blood mononuclear cells, but prostaglandin secretion decreases their IL-2 production.	Prostaglandins	271-284	interleukin 1 alpha	Homo sapiens	182-186
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Mifepristone	14-19	interleukin 1 alpha	Homo sapiens	247-251
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Dexamethasone	159-172	interleukin 1 alpha	Homo sapiens	247-251
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Dexamethasone	174-177	interleukin 1 alpha	Homo sapiens	247-251
7947352-6	1994	Dex decreased in a dose-dependent manner the release of the above four lymphokines, with an ID50 of 0.9 +/- 0.1, 4.76 +/- 0.4, 9.8 +/- 1.8, and 1.16 +/- 0.2 nM for IL-1, IL-6, IL-8 and TNF-alpha, respectively.	Dexamethasone	0-3	interleukin 1 alpha	Homo sapiens	164-168
7861725-3	1994	We found that HPMC are capable of secreting IL-1 alpha and -beta in response to stimulation by these substances, but stimulation with a combination of LPS + TNF alpha, LPS + IL-1 alpha, or TNF alpha + IL-1 alpha, had a marked synergistic effect on cytokine production.	hydroxypropylmethylcellulose-lactose matrix	14-18	interleukin 1 alpha	Homo sapiens	44-54
7858418-5	1994	Based on the work of others which showed a marked synergism between IL-1 alpha and cisplatin, apparently mediated by H2O2 derived from tumour-infiltrating macrophages, we reasoned that the biotherapy could enhance the cytotoxicity of the CVD regimen.	Hydrogen Peroxide	117-121	interleukin 1 alpha	Homo sapiens	68-78
8083217-0	1994	Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts.	Tretinoin	52-65	interleukin 1 alpha	Homo sapiens	19-32
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	0-13	interleukin 1 alpha	Homo sapiens	123-142
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	0-13	interleukin 1 alpha	Homo sapiens	144-154
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	15-17	interleukin 1 alpha	Homo sapiens	123-142
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	15-17	interleukin 1 alpha	Homo sapiens	144-154
8077674-10	1994	Below this activation threshold, i.e., at 10(-12) M, melatonin does not induce the cell-associated IL-1 alpha and IL-1 beta activities, but does induce the mRNA for both IL-1 (alpha and beta).	Melatonin	53-62	interleukin 1 alpha	Homo sapiens	170-181
7820583-5	1994	The rhIL-1 beta-induced enhancement of nociceptive responses of WDR neurons was completely abolished by pretreatment with either IL-1 receptor antagonist, Na salicylate or alpha-melanocyte stimulating hormone.	na salicylate	155-168	interleukin 1 alpha	Homo sapiens	6-10
8086487-1	1994	The effect of individual fatty acids on the proliferation of thymic lymphocytes in response to interleukin-1 (IL-1) was investigated.	Fatty Acids	25-36	interleukin 1 alpha	Homo sapiens	95-108
8086487-1	1994	The effect of individual fatty acids on the proliferation of thymic lymphocytes in response to interleukin-1 (IL-1) was investigated.	Fatty Acids	25-36	interleukin 1 alpha	Homo sapiens	110-114
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	c20 fatty acids	124-139	interleukin 1 alpha	Homo sapiens	72-76
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	8,11,14-Eicosatrienoic Acid	140-167	interleukin 1 alpha	Homo sapiens	72-76
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	8,11,14-Eicosatrienoic Acid	169-173	interleukin 1 alpha	Homo sapiens	72-76
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	Arachidonic Acid	176-192	interleukin 1 alpha	Homo sapiens	72-76
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	197-218	interleukin 1 alpha	Homo sapiens	72-76
8086487-3	1994	A concentration-dependent inhibition (in the range 1-100 microM) in the IL-1-stimulated proliferation was observed with the C20 fatty acids dihomo-gamma-linolenic acid (DGLA), arachidonic acid and eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	220-223	interleukin 1 alpha	Homo sapiens	72-76
7847805-0	1994	Potentiation of antitumor activities of carboplatin and camptothecin by interleukin-1 alpha against human ovarian carcinoma in vivo.	Carboplatin	40-51	interleukin 1 alpha	Homo sapiens	72-91
7847805-0	1994	Potentiation of antitumor activities of carboplatin and camptothecin by interleukin-1 alpha against human ovarian carcinoma in vivo.	Camptothecin	56-68	interleukin 1 alpha	Homo sapiens	72-91
7847805-1	1994	Interleukin-1 alpha significantly potentiated the cytotoxicity of carboplatin (8-fold) and camptothecin (4-fold) during simultaneous drug exposure in human ovarian NIH: OVCAR-3 cancer cells in vitro.	Carboplatin	66-77	interleukin 1 alpha	Homo sapiens	0-19
7847805-1	1994	Interleukin-1 alpha significantly potentiated the cytotoxicity of carboplatin (8-fold) and camptothecin (4-fold) during simultaneous drug exposure in human ovarian NIH: OVCAR-3 cancer cells in vitro.	Camptothecin	91-103	interleukin 1 alpha	Homo sapiens	0-19
7827285-5	1994	TNF, IFN-alpha and IFN-gamma decreased fatty acid synthesis while IL-1 increased fatty acid synthesis.	Fatty Acids	81-91	interleukin 1 alpha	Homo sapiens	66-70
7827285-10	1994	IL-1 caused a slight increase in fatty acid synthesis and increased acetyl CoA carboxylase mRNA levels.	Fatty Acids	33-43	interleukin 1 alpha	Homo sapiens	0-4
7833939-0	1994	Dinucleotide repeat polymorphism in the human IL1A gene.	Dinucleoside Phosphates	0-12	interleukin 1 alpha	Homo sapiens	46-50
7962965-0	1994	Effects of etretinate on keratinocyte proliferation and secretion of interleukin-1 alpha (IL-1 alpha) and IL-8.	Etretinate	11-21	interleukin 1 alpha	Homo sapiens	69-88
7962965-0	1994	Effects of etretinate on keratinocyte proliferation and secretion of interleukin-1 alpha (IL-1 alpha) and IL-8.	Etretinate	11-21	interleukin 1 alpha	Homo sapiens	90-100
7962965-5	1994	Etretinate was shown to have an effect on either IL-1 alpha or IL-8 secretion in unstimulated NHKs.	Etretinate	0-10	interleukin 1 alpha	Homo sapiens	49-59
7962965-6	1994	In HSC-1, a human squamous cell carcinoma cell line cultured in 20% FCS/DMEM, inhibited IL-1 alpha secretion and enhanced IL-8 secretion.	dmem	72-76	interleukin 1 alpha	Homo sapiens	88-98
7962965-8	1994	Stimulation of NHKs with PMA significantly enhanced IL-1 alpha and IL-8 secretion, and these effects were inhibited by etretinate.	Etretinate	119-129	interleukin 1 alpha	Homo sapiens	52-62
7931789-2	1994	We compared the effect of particle composition (titanium and polymethylmethacrylate as inherent components of prosthetic materials or bone cement and polystyrene as a reference material) on the secretion of interleukin-1 and prostaglandin E2 by peritoneal macrophages and monocyte/macrophage cell lines (P388D1 and IC-21) and on the bone-resorbing activity of conditioned medium harvested from these particle-challenged macrophages.	Titanium	48-56	interleukin 1 alpha	Homo sapiens	207-220
7931789-2	1994	We compared the effect of particle composition (titanium and polymethylmethacrylate as inherent components of prosthetic materials or bone cement and polystyrene as a reference material) on the secretion of interleukin-1 and prostaglandin E2 by peritoneal macrophages and monocyte/macrophage cell lines (P388D1 and IC-21) and on the bone-resorbing activity of conditioned medium harvested from these particle-challenged macrophages.	Polymethyl Methacrylate	61-83	interleukin 1 alpha	Homo sapiens	207-220
7967307-6	1994	For example, blocking IL-1-induced prostaglandins is one target in treating inflammatory diseases.	Prostaglandins	35-49	interleukin 1 alpha	Homo sapiens	22-26
7967307-8	1994	Blocking IL-1, in contrast, reduces only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of prostaglandins necessary for physiologic homeostasis.	Prostaglandins	57-70	interleukin 1 alpha	Homo sapiens	9-13
7967307-8	1994	Blocking IL-1, in contrast, reduces only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of prostaglandins necessary for physiologic homeostasis.	Prostaglandins	57-70	interleukin 1 alpha	Homo sapiens	97-101
7967307-8	1994	Blocking IL-1, in contrast, reduces only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of prostaglandins necessary for physiologic homeostasis.	Prostaglandins	128-142	interleukin 1 alpha	Homo sapiens	9-13
7982043-5	1994	In the presence of ouabain, the hTNF alpha- or hIL-1 alpha-induced current was reduced over a wide range of membrane potential, so that the current reversed at about + 20 mV.	Ouabain	19-26	interleukin 1 alpha	Homo sapiens	47-58
8053890-6	1994	Elevation of intracellular calcium levels by A23187, as well as by thapsigargin, was found to lead to specific down-regulation of MRP8/MRP14 mRNA which is in contrast with data reported for inflammatory factors such as interleukin-1 or tumour necrosis factor alpha.	Calcium	27-34	interleukin 1 alpha	Homo sapiens	219-264
7917990-0	1994	Effect of nickel on the activation state of normal human keratinocytes through interleukin 1 and intercellular adhesion molecule 1 expression.	Nickel	10-16	interleukin 1 alpha	Homo sapiens	79-130
7917990-3	1994	In comparison with controls, the addition of subtoxic NiSO4 concentrations (0.1-20 micrograms/ml) to keratinocyte cultures induced a significant, but low release of IL-1 alpha and IL-1 beta at 24 and 48 h, detectable by enzyme-linked immunosorbent assay of the supernatants of treated cells.	nickel sulfate	54-59	interleukin 1 alpha	Homo sapiens	165-175
8000705-2	1994	When NHKs were treated with PGE1 directly, only a slight increase in cell growth and a transient decrease in interleukin 1 alpha (IL-1 alpha) secretion were observed.	Alprostadil	28-32	interleukin 1 alpha	Homo sapiens	109-128
8000705-2	1994	When NHKs were treated with PGE1 directly, only a slight increase in cell growth and a transient decrease in interleukin 1 alpha (IL-1 alpha) secretion were observed.	Alprostadil	28-32	interleukin 1 alpha	Homo sapiens	130-140
8000705-6	1994	Following PGE1 treatment, IL-1 alpha and TGF alpha from HDFs remained undetectable while IL-6 production was enhanced markedly.	Alprostadil	10-14	interleukin 1 alpha	Homo sapiens	26-36
7518838-5	1994	The IC50 of alpha-tcp on an IL-1-induced response was 45 microM.	alpha-Tocopherol	12-21	interleukin 1 alpha	Homo sapiens	28-32
7739201-7	1994	IL-1 alpha increased nitrite release in a dose-dependent fashion and a significant enhancement (p &lt; 0.01) was attained at 10 U/ml.	Nitrites	21-28	interleukin 1 alpha	Homo sapiens	0-10
7739201-8	1994	OBs released 14.2 nmol/4.0 x 10(4) cells of nitrite after 72 hrs stimulation by 100 U/ml IL-1 alpha.	Nitrites	44-51	interleukin 1 alpha	Homo sapiens	89-99
7999926-0	1994	Development of glycosylated human interleukin-1 alpha, neoglyco IL-1 alpha, coupled with D-mannose dimer: synthesis and biological activities in vitro.	Mannose	89-98	interleukin 1 alpha	Homo sapiens	34-53
7999926-2	1994	In order to investigate the effect of carbohydrate introduction on IL-1 activity and to develop IL-1 with less deleterious effects recombinant human IL-1 alpha was chemically coupled with mannose dimers, alpha-D-Man1-6-D-Man[Man2(alpha 1,6)] and alpha-D-Man1-4-D-Man[Man2(alpha 1,4)].	Mannose	188-195	interleukin 1 alpha	Homo sapiens	149-159
7999926-3	1994	About 5 molecules of mannose dimers were introduced per molecule of IL-1.	Mannose	21-28	interleukin 1 alpha	Homo sapiens	68-72
7999926-5	1994	Conversely, antibody against the mannose dimer reacted with only glycosylated IL-1.	Mannose	33-40	interleukin 1 alpha	Homo sapiens	78-82
7999926-6	1994	The effect of glycosylation on IL-1 activity was evaluated by measuring a variety of IL-1 activities in vitro, including proliferative effect on T cells, antiproliferative effect on melanoma cells, stimulatory effect on IL-6 synthesis by melanoma cells, and stimulatory effect on prostaglandin E2 synthesis by fibroblast cells.	Dinoprostone	280-296	interleukin 1 alpha	Homo sapiens	31-35
7969016-7	1994	However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities.	Polymethyl Methacrylate	14-36	interleukin 1 alpha	Homo sapiens	86-96
7969016-7	1994	However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities.	Polymethyl Methacrylate	38-42	interleukin 1 alpha	Homo sapiens	86-96
20692984-7	1994	When chlorpromazine was tested on EPISKIN, an increase in cytotoxicity and release of interleukin 1alpha followed UVA irradiation.	Chlorpromazine	5-19	interleukin 1 alpha	Homo sapiens	86-104
20692984-9	1994	The chlorpromazine-induced inflammatory reaction was also reflected by a more intense release of interleukin 1alpha in the underlying media of EPISKIN.	Chlorpromazine	4-18	interleukin 1 alpha	Homo sapiens	97-115
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Phosphatidylcholines	120-139	interleukin 1 alpha	Homo sapiens	44-57
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Ceramides	155-163	interleukin 1 alpha	Homo sapiens	44-57
8034680-3	1994	Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis.	Sphingomyelins	201-214	interleukin 1 alpha	Homo sapiens	44-57
7957239-0	1994	Interleukin-1-induced prostaglandin E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase A2 and cyclooxygenase-2.	Dinoprostone	22-38	interleukin 1 alpha	Homo sapiens	0-13
7957239-1	1994	Treatment of human synovial cells with interleukin-1 (IL-1) results in a large increase in the production of prostaglandin E2 (PGE2), a function in which the activation of phospholipase A2 (PLA2) is a key step.	Dinoprostone	109-125	interleukin 1 alpha	Homo sapiens	39-52
7701874-1	1994	Paraformaldehyde-fixed tissue of chronic granulomatous skin conditions, such as cutaneous leishmaniasis, granuloma annulare, leprosy and hidroadenitis, was investigated for the presence of interleukin-1 alpha-, interleukin-1 beta-, interleukin-6- and tumour necrosis factor-alpha-like immunoreactivities among the cellular infiltrates.	paraform	0-16	interleukin 1 alpha	Homo sapiens	189-202
7741033-6	1994	Cetirizine (10 micrograms/ml) significantly enhanced IL-1 release by human monocytes stimulated by a weak LPS concentration (1 microgram/ml) but could not modify the maximal increase of IL-1 release induced by 10 micrograms/ml of LPS.	Cetirizine	0-10	interleukin 1 alpha	Homo sapiens	53-57
7741033-12	1994	Cetirizine did not directly modify IL-1 generation by resting monocytes but the IL-1 production observed after LPS stimulation could promote the mechanisms by which PGE2 is released.	Dinoprostone	165-169	interleukin 1 alpha	Homo sapiens	80-84
7741042-1	1994	CGP 47969A is a novel piperazine derivative that inhibits the synthesis of inflammatory cytokines, such as interleukin-1 alpha (IL-1), IL-1 beta and tumor necrosis factor alpha (TNF), in human monocytes stimulated with lipopolysaccharide (LPS), zymosan or IL-1 itself.	Piperazine	22-32	interleukin 1 alpha	Homo sapiens	107-126
7524649-4	1994	DHA, but not eicosapentaenoic acid, decreased in a dose- and time-dependent fashion the expression of vascular cell adhesion molecule 1 (VCAM-1) induced by interleukin (IL)-1, tumor necrosis factor (TNF), IL-4, or bacterial lipopolysaccharide, with half-maximum inhibition at &lt; 10 mumol/L.	Docosahexaenoic Acids	0-3	interleukin 1 alpha	Homo sapiens	156-174
7524649-8	1994	In parallel with reduced surface VCAM-1 protein expression, DHA reduced VCAM-1 mRNA induction by IL-1 or TNF.	Docosahexaenoic Acids	60-63	interleukin 1 alpha	Homo sapiens	97-101
7893968-4	1994	A23187 induced the processing of 33 kDa IL-1 alpha and selectively released processed 17 kDa IL-1 alpha, without any change in the release of 33 kDa IL-1 alpha.	Calcimycin	0-6	interleukin 1 alpha	Homo sapiens	40-50
7893968-4	1994	A23187 induced the processing of 33 kDa IL-1 alpha and selectively released processed 17 kDa IL-1 alpha, without any change in the release of 33 kDa IL-1 alpha.	Calcimycin	0-6	interleukin 1 alpha	Homo sapiens	93-103
7893968-4	1994	A23187 induced the processing of 33 kDa IL-1 alpha and selectively released processed 17 kDa IL-1 alpha, without any change in the release of 33 kDa IL-1 alpha.	Calcimycin	0-6	interleukin 1 alpha	Homo sapiens	93-103
7893968-5	1994	When extracellular calcium was chelated by EGTA, or when intracellular calpain was inhibited by the cell-permeable cysteine-protease inhibitor, E64d, the processing of 33 kDa IL-1 alpha was significantly blocked, the release of 33 kDa IL-1 alpha being unchanged.	Calcium	19-26	interleukin 1 alpha	Homo sapiens	175-185
7893968-5	1994	When extracellular calcium was chelated by EGTA, or when intracellular calpain was inhibited by the cell-permeable cysteine-protease inhibitor, E64d, the processing of 33 kDa IL-1 alpha was significantly blocked, the release of 33 kDa IL-1 alpha being unchanged.	Calcium	19-26	interleukin 1 alpha	Homo sapiens	235-245
7893968-5	1994	When extracellular calcium was chelated by EGTA, or when intracellular calpain was inhibited by the cell-permeable cysteine-protease inhibitor, E64d, the processing of 33 kDa IL-1 alpha was significantly blocked, the release of 33 kDa IL-1 alpha being unchanged.	Egtazic Acid	43-47	interleukin 1 alpha	Homo sapiens	175-185
7868298-6	1994	For example, the IC50 for suramin inhibiting IL-1 alpha and IL-1 beta binding to soluble human IL-1 receptor were 204 microM and 186 microM, respectively.	Suramin	26-33	interleukin 1 alpha	Homo sapiens	45-55
7927949-5	1994	In parallel, IL-1 alpha-induced stimulation of apo-D and GCDFP-15 secretion was additive to that exerted by DHT or DEX.	Dexamethasone	115-118	interleukin 1 alpha	Homo sapiens	13-23
7960581-4	1994	Interleukin-1-alpha (IL-1-alpha) was added to some cultures to examine its effect on MLCER: The lymphocyte responses were measured by 3H-thymidine uptake for the last 18 hours of incubation in MLCER: RESULTS: IFN-gamma-treated, HLA-class-II-bearing HCE cells stimulated allogenic lymphocytes, whereas IFN-gamma nontreated, class-II-negative HCE cells did not.	Tritium	134-136	interleukin 1 alpha	Homo sapiens	0-19
7960581-4	1994	Interleukin-1-alpha (IL-1-alpha) was added to some cultures to examine its effect on MLCER: The lymphocyte responses were measured by 3H-thymidine uptake for the last 18 hours of incubation in MLCER: RESULTS: IFN-gamma-treated, HLA-class-II-bearing HCE cells stimulated allogenic lymphocytes, whereas IFN-gamma nontreated, class-II-negative HCE cells did not.	Thymidine	137-146	interleukin 1 alpha	Homo sapiens	0-19
7960581-6	1994	In addition, exogenous IL-1-alpha reduced the lymphocyte response in MLCER: This effort was inhibited by indomethacin.	Indomethacin	105-117	interleukin 1 alpha	Homo sapiens	23-33
7525650-3	1994	Gold sodium thiomalate inhibited cytokine (TNF, IL-1, IL-4)-stimulated expression of vascular cell adhesion molecule-1 and E-selectin but not intercellular adhesion molecule-1 on endothelial cells.	Gold Sodium Thiomalate	0-22	interleukin 1 alpha	Homo sapiens	48-52
7964160-0	1994	The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction.	Diglycerides	12-26	interleukin 1 alpha	Homo sapiens	69-82
7964160-0	1994	The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction.	Ceramides	31-39	interleukin 1 alpha	Homo sapiens	69-82
7964160-3	1994	Two lipid second messengers have been found to transmit TNF and IL-1 intracellular signals: 1,2-diacylglycerol (DAG), generated by a phosphatidylcholine-specific phospholipase C, and ceramide, generated by sphingomyelinase (SMase).	1,2-diacylglycerol	92-110	interleukin 1 alpha	Homo sapiens	64-68
7964160-3	1994	Two lipid second messengers have been found to transmit TNF and IL-1 intracellular signals: 1,2-diacylglycerol (DAG), generated by a phosphatidylcholine-specific phospholipase C, and ceramide, generated by sphingomyelinase (SMase).	1,2-diacylglycerol	112-115	interleukin 1 alpha	Homo sapiens	64-68
7964160-3	1994	Two lipid second messengers have been found to transmit TNF and IL-1 intracellular signals: 1,2-diacylglycerol (DAG), generated by a phosphatidylcholine-specific phospholipase C, and ceramide, generated by sphingomyelinase (SMase).	Ceramides	183-191	interleukin 1 alpha	Homo sapiens	64-68
7964160-4	1994	DAG is a well established activator of the important signaling system protein kinase C (PKC), which appears to mediate various cellular responses to TNF or IL-1.	1,2-diacylglycerol	0-3	interleukin 1 alpha	Homo sapiens	156-160
7964161-6	1994	In the past three years, several groups reported that IL-1 and tumor necrosis factor (TNF) rapidly induce sphingomyelin turnover in various types of cells, producing ceramide, which may act as a second messenger molecule in an intracellular signaling cascade.	Ceramides	166-174	interleukin 1 alpha	Homo sapiens	54-58
7926002-1	1994	Interleukin-1 alpha and beta induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed.	Nitric Oxide	72-84	interleukin 1 alpha	Homo sapiens	0-19
7926002-1	1994	Interleukin-1 alpha and beta induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed.	Alginates	128-136	interleukin 1 alpha	Homo sapiens	0-19
7930685-6	1994	LipofectAMINE caused the highest release of IL-1 alpha, whereas the lipofectACE and polybrene-DMSO mediated transfection with confluent cells released the least.	Lipofectamine	0-13	interleukin 1 alpha	Homo sapiens	44-54
7861725-3	1994	We found that HPMC are capable of secreting IL-1 alpha and -beta in response to stimulation by these substances, but stimulation with a combination of LPS + TNF alpha, LPS + IL-1 alpha, or TNF alpha + IL-1 alpha, had a marked synergistic effect on cytokine production.	hydroxypropylmethylcellulose-lactose matrix	14-18	interleukin 1 alpha	Homo sapiens	174-184
7861725-3	1994	We found that HPMC are capable of secreting IL-1 alpha and -beta in response to stimulation by these substances, but stimulation with a combination of LPS + TNF alpha, LPS + IL-1 alpha, or TNF alpha + IL-1 alpha, had a marked synergistic effect on cytokine production.	hydroxypropylmethylcellulose-lactose matrix	14-18	interleukin 1 alpha	Homo sapiens	174-184
7861725-7	1994	Cycloheximide and actinomycin D blocked the production of IL-1 alpha and -beta protein, showing that de novo production of IL-1 or synthesis of mRNA stabilizing proteins are needed after stimulation.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	58-78
7861725-7	1994	Cycloheximide and actinomycin D blocked the production of IL-1 alpha and -beta protein, showing that de novo production of IL-1 or synthesis of mRNA stabilizing proteins are needed after stimulation.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	58-62
7861725-7	1994	Cycloheximide and actinomycin D blocked the production of IL-1 alpha and -beta protein, showing that de novo production of IL-1 or synthesis of mRNA stabilizing proteins are needed after stimulation.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	58-78
7861725-7	1994	Cycloheximide and actinomycin D blocked the production of IL-1 alpha and -beta protein, showing that de novo production of IL-1 or synthesis of mRNA stabilizing proteins are needed after stimulation.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	58-62
7521369-10	1994	Activated NF-kappa B was apparent from 20 min and remained for up to 24 h. N-acetylcysteine (NAC) and pyrollidinedithiocarbamate (PDTC), which were shown to inhibit activation of NF-kappa B in Jurkat E6.1 lymphoblasts and EL4.NOB-1 thymoma, failed to block IL-1 activation of NF-kappa B in 1321N1 astrocytoma.	Acetylcysteine	75-91	interleukin 1 alpha	Homo sapiens	257-261
7521369-10	1994	Activated NF-kappa B was apparent from 20 min and remained for up to 24 h. N-acetylcysteine (NAC) and pyrollidinedithiocarbamate (PDTC), which were shown to inhibit activation of NF-kappa B in Jurkat E6.1 lymphoblasts and EL4.NOB-1 thymoma, failed to block IL-1 activation of NF-kappa B in 1321N1 astrocytoma.	Acetylcysteine	93-96	interleukin 1 alpha	Homo sapiens	257-261
7521369-10	1994	Activated NF-kappa B was apparent from 20 min and remained for up to 24 h. N-acetylcysteine (NAC) and pyrollidinedithiocarbamate (PDTC), which were shown to inhibit activation of NF-kappa B in Jurkat E6.1 lymphoblasts and EL4.NOB-1 thymoma, failed to block IL-1 activation of NF-kappa B in 1321N1 astrocytoma.	pyrollidinedithiocarbamate	102-128	interleukin 1 alpha	Homo sapiens	257-261
7521369-10	1994	Activated NF-kappa B was apparent from 20 min and remained for up to 24 h. N-acetylcysteine (NAC) and pyrollidinedithiocarbamate (PDTC), which were shown to inhibit activation of NF-kappa B in Jurkat E6.1 lymphoblasts and EL4.NOB-1 thymoma, failed to block IL-1 activation of NF-kappa B in 1321N1 astrocytoma.	prolinedithiocarbamate	130-134	interleukin 1 alpha	Homo sapiens	257-261
8077674-9	1994	Above its monocyte activation threshold, melatonin induces both cell-associated IL-1 alpha and IL-1 beta activities.	Melatonin	41-50	interleukin 1 alpha	Homo sapiens	80-90
7945500-10	1994	Indomethacin partially restored alpha (VI) mRNA expression in IL-1--treated cells.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	62-66
7945501-2	1994	OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production.	Oligonucleotides	152-167	interleukin 1 alpha	Homo sapiens	46-59
7945501-2	1994	OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production.	Oligonucleotides	152-167	interleukin 1 alpha	Homo sapiens	71-75
7945501-2	1994	OBJECTIVE: To prevent the negative effects of interleukin-1 (IL-1) and IL-1-induced IL-6 on cartilage proteoglycan (PG) synthesis, we used an antisense oligonucleotide (ASO) specific for IL-6 messenger RNA (mRNA) to inhibit IL-6 production.	Oligonucleotides, Antisense	169-172	interleukin 1 alpha	Homo sapiens	71-75
7945501-9	1994	Furthermore, IL-6-ASO can prevent the IL-1-induced inhibition of cartilage PG synthesis.	Oligonucleotides, Antisense	18-21	interleukin 1 alpha	Homo sapiens	38-42
7519668-7	1994	The respective effects of histamine, SP, and IL-1 beta were effectively blocked by the histamine H1, SP, and IL-1 receptor antagonists, supporting a receptor-mediated event for these agents.	Histamine	87-96	interleukin 1 alpha	Homo sapiens	45-54
7931789-4	1994	Although exogenous prostaglandin E2 and recombinant human interleukin-1 could significantly increase the 45Ca release and indomethacin significantly reduced both the spontaneous calcium efflux and active 45Ca release from calvarial bones labeled in vivo, the levels of interleukin-1 and prostaglandin E2, alone or together, did not always correlate with the bone-resorbing activity of conditioned media.	Dinoprostone	19-35	interleukin 1 alpha	Homo sapiens	269-282
7931789-4	1994	Although exogenous prostaglandin E2 and recombinant human interleukin-1 could significantly increase the 45Ca release and indomethacin significantly reduced both the spontaneous calcium efflux and active 45Ca release from calvarial bones labeled in vivo, the levels of interleukin-1 and prostaglandin E2, alone or together, did not always correlate with the bone-resorbing activity of conditioned media.	Indomethacin	122-134	interleukin 1 alpha	Homo sapiens	58-71
7931789-4	1994	Although exogenous prostaglandin E2 and recombinant human interleukin-1 could significantly increase the 45Ca release and indomethacin significantly reduced both the spontaneous calcium efflux and active 45Ca release from calvarial bones labeled in vivo, the levels of interleukin-1 and prostaglandin E2, alone or together, did not always correlate with the bone-resorbing activity of conditioned media.	Indomethacin	122-134	interleukin 1 alpha	Homo sapiens	269-282
7931789-4	1994	Although exogenous prostaglandin E2 and recombinant human interleukin-1 could significantly increase the 45Ca release and indomethacin significantly reduced both the spontaneous calcium efflux and active 45Ca release from calvarial bones labeled in vivo, the levels of interleukin-1 and prostaglandin E2, alone or together, did not always correlate with the bone-resorbing activity of conditioned media.	Dinoprostone	287-303	interleukin 1 alpha	Homo sapiens	58-71
7824535-3	1994	The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo.	Fatty Acids, Omega-3	4-19	interleukin 1 alpha	Homo sapiens	143-156
7824535-3	1994	The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo.	Eicosapentaenoic Acid	28-49	interleukin 1 alpha	Homo sapiens	143-156
7824535-3	1994	The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo.	Eicosapentaenoic Acid	51-54	interleukin 1 alpha	Homo sapiens	143-156
7824535-3	1994	The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo.	Docosahexaenoic Acids	60-80	interleukin 1 alpha	Homo sapiens	143-156
7824535-3	1994	The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo.	Docosahexaenoic Acids	82-85	interleukin 1 alpha	Homo sapiens	143-156
7528721-11	1994	Surprisingly, higher concentrations of verapamil (&gt; 12.5 micrograms/ml) or Ro 40-5967 (5 micrograms/ml) significantly enhanced IL-1-induced expression of ELAM-1.	Verapamil	39-48	interleukin 1 alpha	Homo sapiens	130-134
7528721-11	1994	Surprisingly, higher concentrations of verapamil (&gt; 12.5 micrograms/ml) or Ro 40-5967 (5 micrograms/ml) significantly enhanced IL-1-induced expression of ELAM-1.	ro 40	78-83	interleukin 1 alpha	Homo sapiens	130-134
8034668-8	1994	Dexamethasone alone did not increase PAI-1 mRNA accumulation but enhanced it in combination with IL-1.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	97-101
7519403-7	1994	Both IL-1 and TNF increased release of IL-6 and IL-8 from the cells in a dose-dependent manner and dexamethasone inhibited this effect.	Dexamethasone	99-112	interleukin 1 alpha	Homo sapiens	5-9
7519403-8	1994	Dexamethasone also inhibited the induction of IL-6 and IL-8 RNA by IL-1 and TNF.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	67-79
8018329-8	1994	Interleukin 1 significantly enhanced production of PGE2 by tumor cultures (P &lt; .02).	Dinoprostone	51-55	interleukin 1 alpha	Homo sapiens	0-13
8018657-1	1994	An increase in dermatan sulfate-proteoglycan (DSPG) production occurs in cultured aortic smooth muscle cells exposed to macrophage-conditioned media, an effect that is abrogated by an antibody to interleukin-1 (IL-1).	Dermatan Sulfate	15-31	interleukin 1 alpha	Homo sapiens	196-209
8025949-10	1994	PB-PMNs in culture also showed mRNA expression for IL-1 alpha, IL-1 beta, and TNF alpha in a time- and dose-dependent manner, especially after stimulation with zymosan.	pb-pmns	0-7	interleukin 1 alpha	Homo sapiens	51-61
8025949-10	1994	PB-PMNs in culture also showed mRNA expression for IL-1 alpha, IL-1 beta, and TNF alpha in a time- and dose-dependent manner, especially after stimulation with zymosan.	Zymosan	160-167	interleukin 1 alpha	Homo sapiens	51-61
8020193-0	1994	Retinoic acid effects on endothelial cell function: interaction with interleukin 1.	Tretinoin	0-13	interleukin 1 alpha	Homo sapiens	69-82
8020193-3	1994	To explore alternate hypotheses, we examined the interaction of retinoic acid and IL-1 on endothelial cell (EC) function and found that RA directly affects and modifies the effects of IL-1 on EC proliferation, prostacyclin production, and plasminogen activator inhibitor capacity (PAI-1).	Tretinoin	136-138	interleukin 1 alpha	Homo sapiens	82-86
8020193-3	1994	To explore alternate hypotheses, we examined the interaction of retinoic acid and IL-1 on endothelial cell (EC) function and found that RA directly affects and modifies the effects of IL-1 on EC proliferation, prostacyclin production, and plasminogen activator inhibitor capacity (PAI-1).	Tretinoin	136-138	interleukin 1 alpha	Homo sapiens	184-188
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Epoprostenol	19-31	interleukin 1 alpha	Homo sapiens	169-173
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Tretinoin	53-66	interleukin 1 alpha	Homo sapiens	169-173
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	cis and trans-retinoic acid	88-115	interleukin 1 alpha	Homo sapiens	169-173
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	cis and trans-retinoic acid	88-115	interleukin 1 alpha	Homo sapiens	268-272
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Vitamin A	120-127	interleukin 1 alpha	Homo sapiens	169-173
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Vitamin A	120-127	interleukin 1 alpha	Homo sapiens	268-272
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Epoprostenol	183-195	interleukin 1 alpha	Homo sapiens	169-173
8020193-6	1994	With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1.	Epoprostenol	183-195	interleukin 1 alpha	Homo sapiens	268-272
8020193-8	1994	With respect to plasminogen activator inhibitor capacity, both IL-1 and retinoic acid stimulated EC PAI-1 synthesis, but the individual effects were additive, with RA augmenting the known IL-1 effects on EC PAI-1 production.	Tretinoin	164-166	interleukin 1 alpha	Homo sapiens	188-192
8020193-9	1994	The interaction between RA and IL-1 on the endothelium, described in this study, may play a role in the fashion through which retinoic acid alters the expression of synovitis in certain types of experimental inflammatory arthritis.	Tretinoin	126-139	interleukin 1 alpha	Homo sapiens	31-35
8005288-2	1994	We have noted the potential for the cytokines IL-1 alpha, IL-1 beta, and TNF alpha to stimulate reactive oxygen species production by fertile donor sperm at levels that are consistent with the levels of IL-1 occurring in human seminal plasma.	Reactive Oxygen Species	96-119	interleukin 1 alpha	Homo sapiens	46-56
8040027-0	1994	Interleukin 1 increases thymidine labeling index of normal tissues of mice but not the tumor.	Thymidine	24-33	interleukin 1 alpha	Homo sapiens	0-13
8040027-7	1994	RESULTS: The thymidine labeling index of normal tissues was higher following the injection of recombinant human interleukin 1 24 h before radiolabeling.	Thymidine	13-22	interleukin 1 alpha	Homo sapiens	112-125
8040027-10	1994	A single interleukin 1 injection 24 h before the first radiation fraction also increased the thymidine labeling indices of normal tissues after localized fractionated irradiation.	Thymidine	93-102	interleukin 1 alpha	Homo sapiens	9-22
8040027-12	1994	The ability of interleukin 1 to enhance the thymidine labeling index declined after the first day following the completion of fractionated irradiation.	Thymidine	44-53	interleukin 1 alpha	Homo sapiens	15-28
8040027-13	1994	CONCLUSION: Recombinant human interleukin 1 increased the 24 h thymidine labeling index in normal tissues in mice, but not in RIF-1 tumor.	Thymidine	63-72	interleukin 1 alpha	Homo sapiens	30-43
7754794-1	1994	It has been reported that lithium salt compounds influence hematopoiesis, which is known to be regulated by a number of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6).	lithium salt	26-38	interleukin 1 alpha	Homo sapiens	170-190
7522897-2	1994	The resulting 5-FU-resistant cells were evaluated for (1) the production of GM-CSF-responsive clonogenic elements (CE), (2) the production of IL-3+GM-CSF-responsive CE, and (3) their self-renewal capacity (production of IL-1+IL-3+SCF-responsive CE).	Fluorouracil	14-18	interleukin 1 alpha	Homo sapiens	220-229
8207247-3	1994	In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1 alpha, IL-2 and its receptor, IFN-gamma, IL-3, IL-4, granulocyte-macrophage/CSF, TNF-alpha, and lymphotoxin.	Ciprofloxacin	22-35	interleukin 1 alpha	Homo sapiens	81-91
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	interleukin 1 alpha	Homo sapiens	189-199
7968719-1	1994	N-3 polyunsaturated fatty acids reduce the synthesis of IL-1, the main molecule responsible for fever.	Fatty Acids, Omega-3	0-31	interleukin 1 alpha	Homo sapiens	56-60
7973152-11	1994	Silica-stimulated monocytes from patients also secreted more IL-1 than those from normal subjects (p &lt; 0.001) in autologous mixed lymphocyte reaction.	Silicon Dioxide	0-6	interleukin 1 alpha	Homo sapiens	61-65
7953641-1	1994	We measured iodine-125-labeled recombinant human interleukin-1 alpha (125I-IL-1 alpha) binding in the hippocampus, pituitary, liver, spleen and testis, and plasma adrenocorticotropic hormone (ACTH) and corticosterone levels after i.p.	Iodine-125	12-22	interleukin 1 alpha	Homo sapiens	49-68
8004813-4	1994	In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta.	Cycloheximide	190-203	interleukin 1 alpha	Homo sapiens	249-259
8207201-2	1994	Although PGE2 did not effect T cell binding to EC, concentration-dependent inhibition of the transendothelial migration of T cells through unstimulated or IL-1-activated EC was observed.	Dinoprostone	9-13	interleukin 1 alpha	Homo sapiens	155-159
7516173-9	1994	However, the magnitude of this effect could not fully account for the potency of the glucocorticoid-induced alterations in IL-6 mRNA accumulation and protein production since 10(-6) M dexamethasone caused only a 50% decrease in IL-1-induced IL-6 gene transcription.	Dexamethasone	184-197	interleukin 1 alpha	Homo sapiens	228-232
8004813-4	1994	In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta.	Cycloheximide	190-203	interleukin 1 alpha	Homo sapiens	249-259
8004813-4	1994	In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta.	Cycloheximide	190-203	interleukin 1 alpha	Homo sapiens	249-259
8004813-6	1994	Dexamethasone suppressed both gene expression and protein production of GM-CSF, IL-6 and IL-8 when fibroblasts were exposed to IL-1 alpha.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	127-137
8004823-4	1994	IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6).	Nickel	127-133	interleukin 1 alpha	Homo sapiens	0-10
8004823-4	1994	IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6).	Nickel	178-184	interleukin 1 alpha	Homo sapiens	0-10
8006454-7	1994	Croton oil, phenol, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1 alpha without a concomitant release into the medium.	Croton Oil	0-10	interleukin 1 alpha	Homo sapiens	108-118
7982721-6	1994	Both the mitogen-stimulated and the interleukin-1 (IL-1)-enhanced IL-2 production were completely inhibited by 1 mA of DC applied for 20 min.	Deoxycytidine	119-121	interleukin 1 alpha	Homo sapiens	36-55
8006454-7	1994	Croton oil, phenol, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1 alpha without a concomitant release into the medium.	Phenol	12-18	interleukin 1 alpha	Homo sapiens	108-118
8006454-7	1994	Croton oil, phenol, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1 alpha without a concomitant release into the medium.	Benzalkonium Compounds	20-41	interleukin 1 alpha	Homo sapiens	108-118
8006454-7	1994	Croton oil, phenol, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1 alpha without a concomitant release into the medium.	Dinitrofluorobenzene	47-67	interleukin 1 alpha	Homo sapiens	108-118
8006454-9	1994	Studies using neutralizing antibodies to tumor necrosis factor alpha and IL-1 alpha demonstrated that IL-8 induction by croton oil and phenol occurred directly rather than through autocrine circuits.	Croton Oil	120-130	interleukin 1 alpha	Homo sapiens	73-83
8066833-4	1994	In particular interleukin-1 and tumor necrosis factor alpha, released from activated macrophages, have been shown to inhibit erythropoiesis and might initiate changes in iron metabolism.	Iron	170-174	interleukin 1 alpha	Homo sapiens	14-59
7948430-3	1994	In the presence of indomethacin, an inhibitor of cyclooxygenase, IL-1 inhibited the expression of IL-1R mRNA within 4 h after treatment, and the inhibition sustained at least for 24 h. IL-1 beta as well as IL-1 alpha at higher than 1 U/ml exhibited the inhibitory effect.	Indomethacin	19-31	interleukin 1 alpha	Homo sapiens	206-216
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	interleukin 1 alpha	Homo sapiens	24-28
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	interleukin 1 alpha	Homo sapiens	225-229
7913702-0	1994	IL-1 alpha-induced expression of ICAM-1 on cultured hyperproliferative keratinocytes: suppression by antipsoriatic dimethyl-fumarate.	Dimethyl Fumarate	115-132	interleukin 1 alpha	Homo sapiens	0-10
8195120-5	1994	By Northern blotting analysis, the increased expression of IL1 alpha, IL1 beta, and IL6 genes was shown to occur at 30 min of Mit C and MMS treatment and to decline after 8 h. Similarly, EMS up-regulated the expression of IL1 beta and IL6 genes.	Methyl Methanesulfonate	136-139	interleukin 1 alpha	Homo sapiens	59-68
8175759-2	1994	A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).	Dexamethasone	18-31	interleukin 1 alpha	Homo sapiens	210-214
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	112-116
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	134-147	interleukin 1 alpha	Homo sapiens	112-116
8175759-7	1994	Finally, dexamethasone diminished the IL-1-induced formation of NF-kappa B complexes, which were identified immunochemically to consist of p50 and p65, without reducing the amount of translocated factors.	Dexamethasone	9-22	interleukin 1 alpha	Homo sapiens	38-42
8033515-11	1994	Indomethacin or ICI 207968 inhibited the short-circuit current response to interleukin-1 and a combination of these antagonists produced a greater inhibition.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	75-88
8033515-11	1994	Indomethacin or ICI 207968 inhibited the short-circuit current response to interleukin-1 and a combination of these antagonists produced a greater inhibition.	2-(3-pyridylmethyl)indazolinone	16-26	interleukin 1 alpha	Homo sapiens	75-88
8180676-7	1994	The production of prostaglandin E2 was accelerated significantly by either IL-1 or IL-2 at a dose of 10 pmol/l.	Dinoprostone	18-34	interleukin 1 alpha	Homo sapiens	75-79
7913702-3	1994	We, therefore, studied the effect of dimethyl-fumarate ester (DMF) on the putative IL-1-induced ICAM-1 expression.	dimethyl-fumarate ester	37-60	interleukin 1 alpha	Homo sapiens	83-87
7913702-3	1994	We, therefore, studied the effect of dimethyl-fumarate ester (DMF) on the putative IL-1-induced ICAM-1 expression.	Dimethylformamide	62-65	interleukin 1 alpha	Homo sapiens	83-87
8169657-7	1994	Glutathione did not have an effect on interleukin-1 production by PBMC from young subjects; however, GSH supplementation tended (P = 0.08) to increase interleukin-1 production by PBMC from old subjects.	Glutathione	101-104	interleukin 1 alpha	Homo sapiens	151-164
8064732-5	1994	RESULTS: Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4.	Piroxicam	9-18	interleukin 1 alpha	Homo sapiens	84-88
8064717-4	1994	In combination with the described synovial fibroblast mitogen, interleukin 1 (IL-1), which can also generate a growth inhibitory cyclooxygenase product, the proliferative responses to PDGF, FGF, transforming growth factor alpha, and epidermal growth factor were enhanced; in some, but not in all of these fibroblast cultures containing IL-1, the achievement of maximal DNA synthesis required that the cyclooxygenase inhibitor, indomethacin, be included.	Indomethacin	427-439	interleukin 1 alpha	Homo sapiens	63-82
8064717-4	1994	In combination with the described synovial fibroblast mitogen, interleukin 1 (IL-1), which can also generate a growth inhibitory cyclooxygenase product, the proliferative responses to PDGF, FGF, transforming growth factor alpha, and epidermal growth factor were enhanced; in some, but not in all of these fibroblast cultures containing IL-1, the achievement of maximal DNA synthesis required that the cyclooxygenase inhibitor, indomethacin, be included.	Indomethacin	427-439	interleukin 1 alpha	Homo sapiens	78-82
8041811-2	1994	We here provide evidence that UVA-induced IL-1 alpha and IL-1 beta play a central role in the induction of the synthesis both of IL-6 and collagenase/MMP-1.	uva	30-33	interleukin 1 alpha	Homo sapiens	42-52
8163473-5	1994	We have studied the effect of interleukin-1 alpha (IL-1 alpha), a proinflammatory cytokine that facilitates its actions in part by inducing the synthesis of prostanoids, on the expression of Cox-2 in a human cell line (ECV304) and demonstrated that IL-1 alpha induces a sustained increase in the expression of the Cox-2 mRNA as well as the functional enzyme.	Prostaglandins	157-168	interleukin 1 alpha	Homo sapiens	30-49
8163473-5	1994	We have studied the effect of interleukin-1 alpha (IL-1 alpha), a proinflammatory cytokine that facilitates its actions in part by inducing the synthesis of prostanoids, on the expression of Cox-2 in a human cell line (ECV304) and demonstrated that IL-1 alpha induces a sustained increase in the expression of the Cox-2 mRNA as well as the functional enzyme.	Prostaglandins	157-168	interleukin 1 alpha	Homo sapiens	51-61
7513166-2	1994	Here we report that the rate of synthesis of phosphofetuin by hepatocytes in culture was reduced by inflammatory cytokines such as human interleukin (hIL)-6, human tumor necrosis factor-alpha and hIL-1 alpha, but dose-dependently stimulated by growth factors of hepatocytes, such as hepatocyte growth factor (HGF)/scatter factor (SF), epidermal growth factor and insulin, as determined by metabolic labeling and Northern blot analysis using cDNA for rat fetuin as a probe.	phosphofetuin	45-58	interleukin 1 alpha	Homo sapiens	196-207
8159722-10	1994	In addition, cultured smooth muscle cells expressed SAA1, SAA2, and SAA4 mRNAs when treated with interleukin 1 or 6 (IL-1 or IL-6) in the presence of dexamethasone.	Dexamethasone	150-163	interleukin 1 alpha	Homo sapiens	97-115
8159722-10	1994	In addition, cultured smooth muscle cells expressed SAA1, SAA2, and SAA4 mRNAs when treated with interleukin 1 or 6 (IL-1 or IL-6) in the presence of dexamethasone.	Dexamethasone	150-163	interleukin 1 alpha	Homo sapiens	117-121
8165708-7	1994	Neutralizing antibodies against IL-1 alpha, but not antibodies against IL1 beta, IL-6, or TNF alpha/beta, abrogate the heparan sulfate-mediated increase in cytotoxicity, suggesting that the increase depended in part upon the production of IL-1 alpha.	Heparitin Sulfate	119-134	interleukin 1 alpha	Homo sapiens	32-42
8165708-7	1994	Neutralizing antibodies against IL-1 alpha, but not antibodies against IL1 beta, IL-6, or TNF alpha/beta, abrogate the heparan sulfate-mediated increase in cytotoxicity, suggesting that the increase depended in part upon the production of IL-1 alpha.	Heparitin Sulfate	119-134	interleukin 1 alpha	Homo sapiens	239-249
8178956-0	1994	Interleukin-1 stimulates phosphatidic acid-mediated phospholipase D activity in human mesangial cells.	Phosphatidic Acids	25-42	interleukin 1 alpha	Homo sapiens	0-13
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	167-191	interleukin 1 alpha	Homo sapiens	62-75
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	167-191	interleukin 1 alpha	Homo sapiens	77-81
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	167-191	interleukin 1 alpha	Homo sapiens	102-106
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	193-195	interleukin 1 alpha	Homo sapiens	62-75
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	193-195	interleukin 1 alpha	Homo sapiens	77-81
8178956-1	1994	Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule.	phosphatidylethanolamine	193-195	interleukin 1 alpha	Homo sapiens	102-106
8178956-2	1994	Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA).	phosphatidylethanolamine	149-151	interleukin 1 alpha	Homo sapiens	79-83
8178956-2	1994	Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA).	Phosphatidic Acids	155-172	interleukin 1 alpha	Homo sapiens	79-83
8178956-2	1994	Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA).	Phosphatidic Acids	174-176	interleukin 1 alpha	Homo sapiens	79-83
8178956-7	1994	Blockade of PLD activation by IL-1 antibodies or antibody against the IL-1 receptor is bypassed by stimulation of human mesangial cells with 1,2-sn-dilinoleoyl PA.	1,2-sn-dilinoleoyl pa	141-162	interleukin 1 alpha	Homo sapiens	70-74
8161265-14	1994	Similar to rat KCs, indomethacin prevented PGE2 release while significantly upregulating TNF-alpha, IL-1, and IL-6, but not TGF-beta, consistent with an autoregulatory control of eicosanoids over proinflammatory cytokines.	Indomethacin	20-32	interleukin 1 alpha	Homo sapiens	100-104
8203954-8	1994	Stimulation of IL-1 induced growth by Tenidap was reduced by addition of high levels of exogenous PGE2 (100 ng/ml) although growth was still higher than in IL-1 alone.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	15-19
8203954-8	1994	Stimulation of IL-1 induced growth by Tenidap was reduced by addition of high levels of exogenous PGE2 (100 ng/ml) although growth was still higher than in IL-1 alone.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	156-160
8138241-4	1994	The purpose of this study was to compare the effects of lipopolysaccharide stimulation and peptidoglycan-polysaccharide stimulation of Kupffer cells on release of tumor necrosis factor-alpha and interleukin-1.	peptidoglycan-polysaccharide	91-119	interleukin 1 alpha	Homo sapiens	195-208
8138241-13	1994	After incubation for 8 and 24 hr, 100 micrograms/ml peptidoglycan-polysaccharide had induced significantly more interleukin-1 release from cultured Kupffer cells than had 400 ng/ml lipopolysaccharide (p &lt; 0.001).	peptidoglycan-polysaccharide	52-80	interleukin 1 alpha	Homo sapiens	112-125
7511596-9	1994	Histamine (1-100 microM) enhanced IL-1 alpha-induced synthesis of IL-6 (p &lt; 0.001).	Histamine	0-9	interleukin 1 alpha	Homo sapiens	34-44
7511596-10	1994	Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis.	Cimetidine	0-10	interleukin 1 alpha	Homo sapiens	144-154
7511596-10	1994	Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis.	Ranitidine	15-25	interleukin 1 alpha	Homo sapiens	144-154
7511596-10	1994	Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis.	Histamine	113-122	interleukin 1 alpha	Homo sapiens	144-154
7511596-12	1994	Prostaglandin E2, an activator of adenylate cyclase, also enhanced IL-1 alpha-induced synthesis of IL-6.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	67-77
7511596-13	1994	Histamine increased and sustained steady-state levels of IL-6 mRNA in IL-1 alpha-stimulated cells, but reduced IL-6 mRNA half-life (3.5 h versus 1.8 h).	Histamine	0-9	interleukin 1 alpha	Homo sapiens	70-80
8151314-0	1994	Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer.	Carboplatin	34-45	interleukin 1 alpha	Homo sapiens	11-30
8151314-1	1994	PURPOSE: The purpose of this study was to evaluate the clinical safety and ability of interleukin-1 alpha (IL-1 alpha) to ameliorate carboplatin-induced thrombocytopenia and thus allow patients with ovarian cancer to receive multiple cycles of chemotherapy at full doses.	Carboplatin	133-144	interleukin 1 alpha	Homo sapiens	86-105
8151314-1	1994	PURPOSE: The purpose of this study was to evaluate the clinical safety and ability of interleukin-1 alpha (IL-1 alpha) to ameliorate carboplatin-induced thrombocytopenia and thus allow patients with ovarian cancer to receive multiple cycles of chemotherapy at full doses.	Carboplatin	133-144	interleukin 1 alpha	Homo sapiens	107-117
8151314-2	1994	PATIENTS AND METHODS: IL-1 alpha was administered by continuous intravenous infusion daily at doses of 0.1 to 10 micrograms/m2/24 hours over 4 days (96 hours) before the first cycle and/or following the second cycle of carboplatin in 21 patients with recurrent ovarian cancer who had platinum-responsive disease.	Carboplatin	219-230	interleukin 1 alpha	Homo sapiens	22-32
8151314-2	1994	PATIENTS AND METHODS: IL-1 alpha was administered by continuous intravenous infusion daily at doses of 0.1 to 10 micrograms/m2/24 hours over 4 days (96 hours) before the first cycle and/or following the second cycle of carboplatin in 21 patients with recurrent ovarian cancer who had platinum-responsive disease.	Platinum	284-292	interleukin 1 alpha	Homo sapiens	22-32
8151314-7	1994	IL-1 alpha following carboplatin significantly reduced the duration of thrombocytopenia (days platelet count &lt; 50,000, 5.1 to 2.9 days; P = .003) and increased the area under the curve (AUC) of platelets as a function of time (P &lt; .001).	Carboplatin	21-32	interleukin 1 alpha	Homo sapiens	0-10
8151314-13	1994	Treatment with IL-1 alpha was associated with the tolerance of multiple cycles of carboplatin at the same dose in several patients.	Carboplatin	82-93	interleukin 1 alpha	Homo sapiens	15-25
8151314-15	1994	CONCLUSION: These findings demonstrate that IL-1 alpha can enhance recovery of platelets following carboplatin therapy and suggest a potential therapeutic role for IL-1 alpha in attenuating thrombocytopenia associated with chemotherapy.	Carboplatin	99-110	interleukin 1 alpha	Homo sapiens	44-54
8019842-4	1994	In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin.	Serotonin	225-234	interleukin 1 alpha	Homo sapiens	40-44
8130263-8	1994	Nifedipine also blocked ionomycin and thapsigargin stimulation but only partially blocked bradykinin and interleukin 1 alpha stimulation.	Nifedipine	0-10	interleukin 1 alpha	Homo sapiens	105-124
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	308-312	interleukin 1 alpha	Homo sapiens	192-211
7519403-0	1994	Dexamethasone inhibits IL-1 and TNF activity in human lung fibroblasts without affecting IL-1 or TNF receptors.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	23-27
7519403-3	1994	Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	55-66
7519403-4	1994	In these studies, we determined whether dexamethasone interferes with the upregulation of IL-6 and IL-8 by downregulating expression of the IL-1 or TNF receptor genes.	Dexamethasone	40-53	interleukin 1 alpha	Homo sapiens	140-144
8147926-2	1994	OBJECTIVE: To characterize the effects of interleukin-1 alpha (IL-1) on prostanoid biosynthesis by human rheumatoid synovium microvessel endothelium (HSE).	Prostaglandins	72-82	interleukin 1 alpha	Homo sapiens	42-61
8147926-2	1994	OBJECTIVE: To characterize the effects of interleukin-1 alpha (IL-1) on prostanoid biosynthesis by human rheumatoid synovium microvessel endothelium (HSE).	Prostaglandins	72-82	interleukin 1 alpha	Homo sapiens	63-67
8147926-6	1994	RESULTS: IL-1 induced an increase in COX activity (as assessed by prostaglandin E2 release) that was dose- and time-dependent and was blocked by cycloheximide, actinomycin D, and dexamethasone.	Dinoprostone	66-82	interleukin 1 alpha	Homo sapiens	9-13
8147926-6	1994	RESULTS: IL-1 induced an increase in COX activity (as assessed by prostaglandin E2 release) that was dose- and time-dependent and was blocked by cycloheximide, actinomycin D, and dexamethasone.	Cycloheximide	145-158	interleukin 1 alpha	Homo sapiens	9-13
8147926-6	1994	RESULTS: IL-1 induced an increase in COX activity (as assessed by prostaglandin E2 release) that was dose- and time-dependent and was blocked by cycloheximide, actinomycin D, and dexamethasone.	Dactinomycin	160-173	interleukin 1 alpha	Homo sapiens	9-13
8147926-6	1994	RESULTS: IL-1 induced an increase in COX activity (as assessed by prostaglandin E2 release) that was dose- and time-dependent and was blocked by cycloheximide, actinomycin D, and dexamethasone.	Dexamethasone	179-192	interleukin 1 alpha	Homo sapiens	9-13
8147926-7	1994	IL-1 induced a selective increase in COX II mRNA and biosynthesis of COX II protein that was blocked by dexamethasone.	Dexamethasone	104-117	interleukin 1 alpha	Homo sapiens	0-4
8147926-9	1994	The induction of COX II expression provides, at least in part, a mechanism for the pronounced increase in prostanoid synthesis observed in HSE cells following incubation with IL-1.	Prostaglandins	106-116	interleukin 1 alpha	Homo sapiens	175-179
8175024-5	1994	Similarly, the stimulation of [3H]thymidine incorporation by IL-1 but not by TNF-alpha was blocked by TNF-alpha antisense transfection.	3h]thymidine	31-43	interleukin 1 alpha	Homo sapiens	61-65
21566987-5	1994	Further experiments indicated that interleukin 1 (IL-1), one of the mediators of LPS activity, also synergized with t-RA to stimulate G-CSF secretion.	Tretinoin	116-120	interleukin 1 alpha	Homo sapiens	35-54
8207338-3	1994	Endotoxin induced inflammation indirectly through the release of IL-1 which was inhibited by fewer agents, including CK-17, CK-102 and prednisolone.	CK 102	124-130	interleukin 1 alpha	Homo sapiens	65-69
8207338-3	1994	Endotoxin induced inflammation indirectly through the release of IL-1 which was inhibited by fewer agents, including CK-17, CK-102 and prednisolone.	Prednisolone	135-147	interleukin 1 alpha	Homo sapiens	65-69
8207338-4	1994	However, the direct effect of IL-1 can only be suppressed by CK-17 and prednisolone.	Prednisolone	71-83	interleukin 1 alpha	Homo sapiens	30-34
8207338-7	1994	Most importantly, CK-17 was found to be 2-fold more potent than prednisolone in inhibiting IL-1-induced uveitis, while no side effects were noted at doses tested to date.	Prednisolone	64-76	interleukin 1 alpha	Homo sapiens	91-95
8130263-0	1994	Differential role of extra- and intracellular calcium in bradykinin and interleukin 1 alpha stimulation of arachidonic acid release from A549 cells.	Calcium	46-53	interleukin 1 alpha	Homo sapiens	72-91
8130263-0	1994	Differential role of extra- and intracellular calcium in bradykinin and interleukin 1 alpha stimulation of arachidonic acid release from A549 cells.	Arachidonic Acid	107-123	interleukin 1 alpha	Homo sapiens	72-91
8130263-1	1994	The release of arachidonic acid in A549 cells was stimulated in a time- and dose-dependent manner by the Ca2+ ionophore ionomycin (t1/2 = 4 min), thapsigargin (t1/2 = 8 min), bradykinin (t1/2 = 12 min, EC50 = 3 nM), and interleukin 1 alpha (t1/2 = 28 min, EC50 = 0.3 ng/ml).	Arachidonic Acid	15-31	interleukin 1 alpha	Homo sapiens	220-239
8130263-1	1994	The release of arachidonic acid in A549 cells was stimulated in a time- and dose-dependent manner by the Ca2+ ionophore ionomycin (t1/2 = 4 min), thapsigargin (t1/2 = 8 min), bradykinin (t1/2 = 12 min, EC50 = 3 nM), and interleukin 1 alpha (t1/2 = 28 min, EC50 = 0.3 ng/ml).	Ionomycin	120-129	interleukin 1 alpha	Homo sapiens	220-239
8130263-1	1994	The release of arachidonic acid in A549 cells was stimulated in a time- and dose-dependent manner by the Ca2+ ionophore ionomycin (t1/2 = 4 min), thapsigargin (t1/2 = 8 min), bradykinin (t1/2 = 12 min, EC50 = 3 nM), and interleukin 1 alpha (t1/2 = 28 min, EC50 = 0.3 ng/ml).	Thapsigargin	146-158	interleukin 1 alpha	Homo sapiens	220-239
8130263-2	1994	Bradykinin (10 nM) and interleukin 1 alpha (1 ng/ml) stimulation was blocked by the bradykinin B2 receptor antagonist, D-Arg,[Hyp3,Thi5,8, D-Phe7]bradykinin and interleukin 1 receptor antagonist (IC50 = 30 mM and 20 ng/ml, respectively), suggesting receptor mediation.	D-Arginine	119-124	interleukin 1 alpha	Homo sapiens	23-42
8130263-2	1994	Bradykinin (10 nM) and interleukin 1 alpha (1 ng/ml) stimulation was blocked by the bradykinin B2 receptor antagonist, D-Arg,[Hyp3,Thi5,8, D-Phe7]bradykinin and interleukin 1 receptor antagonist (IC50 = 30 mM and 20 ng/ml, respectively), suggesting receptor mediation.	thi5	131-135	interleukin 1 alpha	Homo sapiens	23-42
8130263-6	1994	However, the presence of EGTA completely abolished bradykinin stimulation and partially blocked the effect of interleukin 1 alpha (43% inhibition).	Egtazic Acid	25-29	interleukin 1 alpha	Homo sapiens	110-129
8130263-7	1994	In the presence of extracellular Ca2+, ionomycin (3 mM), thapsigargin (0.3 mM), bradykinin (10 nM), and interleukin 1 alpha (1 ng/ml) stimulation of arachidonic acid release was blocked by the Ca2+ influx blocker LaCl3 (29, 44, 35, and 41% inhibition, respectively).	Arachidonic Acid	149-165	interleukin 1 alpha	Homo sapiens	104-123
8166301-0	1994	Interleukin-1alpha induced protection against pulmonary oxygen toxicity.	Oxygen	56-62	interleukin 1 alpha	Homo sapiens	0-18
8126130-9	1994	The monocyte cytokines [IL-1 alpha (5 U/mL), IL-1 beta (5 U/mL), and TNF alpha (1000 U/mL) significantly stimulated trophoblast progesterone production (nanograms per mL): JEG-3 control, 4.1 +/- 0.5; IL-1 alpha, 7.8 +/- 0.9; IL-1 beta, 8.8 +/- 0.5; and TNF alpha 7.2 +/- 0.8 (P &lt; 0.05).	Progesterone	128-140	interleukin 1 alpha	Homo sapiens	24-34
8126130-15	1994	We conclude that monocyte IL-1 alpha, IL-1 beta, and TNF alpha may regulate trophoblast progesterone production through paracrine effects.	Progesterone	88-100	interleukin 1 alpha	Homo sapiens	26-36
8299714-0	1994	Interleukin-1 and transforming growth factor-alpha: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts.	Dinoprostone	99-103	interleukin 1 alpha	Homo sapiens	0-50
8006889-1	1994	OBJECTIVE: To investigate the regulation of the prostaglandin (PG) synthesis by interleukin 1 (IL-1) in human synovial cells and chondrocytes.	Prostaglandins	48-61	interleukin 1 alpha	Homo sapiens	80-99
8006889-1	1994	OBJECTIVE: To investigate the regulation of the prostaglandin (PG) synthesis by interleukin 1 (IL-1) in human synovial cells and chondrocytes.	Prostaglandins	63-65	interleukin 1 alpha	Homo sapiens	80-99
8006889-2	1994	METHODS: Both cell types stimulated by human recombinant IL-1 synthesized PGE2, PGF2 alpha and 6-keto-PGF1 alpha.	Dinoprostone	74-78	interleukin 1 alpha	Homo sapiens	57-61
8006889-2	1994	METHODS: Both cell types stimulated by human recombinant IL-1 synthesized PGE2, PGF2 alpha and 6-keto-PGF1 alpha.	Dinoprost	80-84	interleukin 1 alpha	Homo sapiens	57-61
8006889-2	1994	METHODS: Both cell types stimulated by human recombinant IL-1 synthesized PGE2, PGF2 alpha and 6-keto-PGF1 alpha.	6-keto-pgf1	95-106	interleukin 1 alpha	Homo sapiens	57-61
8312373-1	1994	We have investigated the effects of lipopolysaccharide (LPS) and probucol (a lipid soluble antioxidant) on the gene expression of interleukin 1 alpha and beta (IL-1 alpha and IL-1 beta), and platelet-derived growth factor A chain and B chain (PDGF-A and PDGF-B) in the human monocytic cell line U-937.	Probucol	65-73	interleukin 1 alpha	Homo sapiens	130-149
8312373-1	1994	We have investigated the effects of lipopolysaccharide (LPS) and probucol (a lipid soluble antioxidant) on the gene expression of interleukin 1 alpha and beta (IL-1 alpha and IL-1 beta), and platelet-derived growth factor A chain and B chain (PDGF-A and PDGF-B) in the human monocytic cell line U-937.	Probucol	65-73	interleukin 1 alpha	Homo sapiens	160-170
8061933-8	1994	The half-life for IL-1 alpha and IL-1 beta was estimated using actinomycin D treatment.	Dactinomycin	63-76	interleukin 1 alpha	Homo sapiens	18-28
8009810-0	1994	Effects of flurbiprofen on recombinant human IL-1 alpha-induced fever and associated clinical, haematological and blood biochemical changes in the dwarf goat.	Flurbiprofen	11-23	interleukin 1 alpha	Homo sapiens	45-55
8009810-4	1994	Intravenous injection of recombinant human interleukin-1 alpha (r. HuIL-1 alpha: 0.5 microgram/kg) caused shivering, fever, inhibition of rumen contractions, tachycardia, hypoferraemia, hypozincaemia, hyperglycaemia followed by hypoglycaemia, changes in plasma urea and creatinine values, lymphopaenia and neutropaenia followed by neutrophilic leukocytosis.	Urea	261-265	interleukin 1 alpha	Homo sapiens	43-62
8009810-4	1994	Intravenous injection of recombinant human interleukin-1 alpha (r. HuIL-1 alpha: 0.5 microgram/kg) caused shivering, fever, inhibition of rumen contractions, tachycardia, hypoferraemia, hypozincaemia, hyperglycaemia followed by hypoglycaemia, changes in plasma urea and creatinine values, lymphopaenia and neutropaenia followed by neutrophilic leukocytosis.	Creatinine	270-280	interleukin 1 alpha	Homo sapiens	43-62
8180354-4	1994	Putative mediators include peptide hormones (e.g. corticotropin releasing hormone (CRH)) and/or inflammatory-cytokines (e.g. interleukin-1, -6, and -8 (IL-1, -6 and -8)) which promote the production of oxytotic factors (e.g. prostanoids and endothelin) capable of eliciting uterine contractions and enhancing expression of proteases capable of initiating cervical change and/or membrane rupture.	Prostaglandins	225-236	interleukin 1 alpha	Homo sapiens	125-150
8180354-4	1994	Putative mediators include peptide hormones (e.g. corticotropin releasing hormone (CRH)) and/or inflammatory-cytokines (e.g. interleukin-1, -6, and -8 (IL-1, -6 and -8)) which promote the production of oxytotic factors (e.g. prostanoids and endothelin) capable of eliciting uterine contractions and enhancing expression of proteases capable of initiating cervical change and/or membrane rupture.	Prostaglandins	225-236	interleukin 1 alpha	Homo sapiens	152-168
8113250-4	1994	The membranes from implants with a polyethylene articulation produced significantly higher levels of collagenase and interleukin-1 (p &lt; 0.05).	Polyethylene	35-47	interleukin 1 alpha	Homo sapiens	101-130
8294881-10	1994	The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex.	Dexamethasone	17-20	interleukin 1 alpha	Homo sapiens	67-71
8294881-6	1994	Induction of IL-1R II mRNA by Dex was associated with augmented membrane expression and release of the type II IL-1 binding molecule.	Dexamethasone	30-33	interleukin 1 alpha	Homo sapiens	13-17
8294881-9	1994	The concentrations of IL-1 alpha and IL-1 receptor antagonist required to displace the binding of IL-1 beta to the soluble form of the decoy molecule induced by Dex from PMN were, respectively, 100 and 2 times higher compared with IL-1 beta.	Dexamethasone	161-164	interleukin 1 alpha	Homo sapiens	22-32
8193081-0	1994	Regulatory effects of 1,25-dihydroxyvitamin D3 and a novel vitamin D3 analogue MC903 on secretion of interleukin-1 alpha (IL-1 alpha) and IL-8 by normal human keratinocytes and a human squamous cell carcinoma cell line (HSC-1).	Cholecalciferol	36-46	interleukin 1 alpha	Homo sapiens	122-132
8193081-5	1994	In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro.	Calcitriol	79-90	interleukin 1 alpha	Homo sapiens	118-128
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	25-56	interleukin 1 alpha	Homo sapiens	138-148
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 alpha	Homo sapiens	138-148
8294881-10	1994	The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex.	Dexamethasone	148-151	interleukin 1 alpha	Homo sapiens	67-71
8193081-11	1994	Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently.	Calcitriol	12-23	interleukin 1 alpha	Homo sapiens	111-121
8301142-0	1994	Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.	Tretinoin	0-13	interleukin 1 alpha	Homo sapiens	28-32
8193081-11	1994	Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently.	calcipotriene	27-32	interleukin 1 alpha	Homo sapiens	111-121
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	Isotretinoin	0-20	interleukin 1 alpha	Homo sapiens	116-120
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	Vitamin A	22-29	interleukin 1 alpha	Homo sapiens	116-120
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	Retinaldehyde	31-44	interleukin 1 alpha	Homo sapiens	116-120
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	2-octenal	50-55	interleukin 1 alpha	Homo sapiens	116-120
8113959-0	1994	Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes.	muramyl tripeptide	10-28	interleukin 1 alpha	Homo sapiens	42-61
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	Acitretin	56-63	interleukin 1 alpha	Homo sapiens	116-120
8113959-4	1994	Monocyte interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha expression were all up-regulated after a 2-h incubation with L-MTP-PE.	L-MTP-PE	156-164	interleukin 1 alpha	Homo sapiens	9-33
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	Alitretinoin	81-100	interleukin 1 alpha	Homo sapiens	116-120
8301142-12	1994	These studies demonstrate that RA and other retinoid analogs inhibit IL-1-induced IL-6 production and that this effect is analog-specific and, at least partially, transcriptionally mediated.	Retinoids	44-52	interleukin 1 alpha	Homo sapiens	69-73
8164327-1	1994	We studied whether human blood mononuclear cells could produce tumor necrosis factor (TNF) and interleukin 1 (IL-1) by surgical stimuli, and if so, prostaglandin E1 (PGE1) could inhibit their increases before and following operation in patients undergoing head-neck surgery.	Alprostadil	166-170	interleukin 1 alpha	Homo sapiens	95-114
8164327-6	1994	Production of IL-1 on the 1st postoperative day increased 1.7 fold in control group and 1.1 fold in PGE1 group compared with those before surgery.	Alprostadil	100-104	interleukin 1 alpha	Homo sapiens	14-18
8296275-5	1994	Tumour necrosis factor, IL1 and IL6 are generally produced as part of the inflammatory reaction and stimulate synthesis of prostaglandin.	Prostaglandins	123-136	interleukin 1 alpha	Homo sapiens	24-27
8186319-0	1994	The inducible expression of THP-1 cell interleukin-1 mRNA: effects of estrogen on differential response to phorbol ester and lipopolysaccharide.	Phorbol Esters	107-120	interleukin 1 alpha	Homo sapiens	39-52
8292041-4	1994	Both genistein and herbimycin A significantly inhibited IL-1 and TNF alpha-induced upregulation of neutrophils (p &lt; 0.05) and monocyte (p &lt; 0.01) adherence.	Genistein	5-14	interleukin 1 alpha	Homo sapiens	56-60
8292041-4	1994	Both genistein and herbimycin A significantly inhibited IL-1 and TNF alpha-induced upregulation of neutrophils (p &lt; 0.05) and monocyte (p &lt; 0.01) adherence.	herbimycin	19-31	interleukin 1 alpha	Homo sapiens	56-60
8292041-5	1994	IL-1 and TNF alpha-stimulated lymphocyte adherence was diminished in the presence of herbimycin A (p &lt; 0.05), but genistein only inhibited TNF alpha-stimulated adherence.	herbimycin	85-97	interleukin 1 alpha	Homo sapiens	0-4
8011537-2	1994	IL-1 alpha, IL-1 beta and TNF-alpha stimulated 3H-TdR uptake in leukaemic blasts in a dose-dependent fashion.	Tritium	47-49	interleukin 1 alpha	Homo sapiens	0-10
8276785-8	1994	While confirming the existence of an autonomous nuclear phosphoinositide signaling system, our data clearly indicate that in SaOS-2 cells one of the earliest events following IL-1 alpha treatment is the breakdown of nuclear phosphatidylinositol monophosphate and phosphatidylinositol bisphosphate because of the activation of a specific nuclear PLC isoform.	Phosphatidylinositols	56-72	interleukin 1 alpha	Homo sapiens	175-185
8276785-8	1994	While confirming the existence of an autonomous nuclear phosphoinositide signaling system, our data clearly indicate that in SaOS-2 cells one of the earliest events following IL-1 alpha treatment is the breakdown of nuclear phosphatidylinositol monophosphate and phosphatidylinositol bisphosphate because of the activation of a specific nuclear PLC isoform.	phosphatidylinositol monophosphate	224-258	interleukin 1 alpha	Homo sapiens	175-185
8276785-8	1994	While confirming the existence of an autonomous nuclear phosphoinositide signaling system, our data clearly indicate that in SaOS-2 cells one of the earliest events following IL-1 alpha treatment is the breakdown of nuclear phosphatidylinositol monophosphate and phosphatidylinositol bisphosphate because of the activation of a specific nuclear PLC isoform.	phosphatidylinositol bisphosphate	263-296	interleukin 1 alpha	Homo sapiens	175-185
7487347-2	1994	Coculture of paraformaldehyde-fixed macrophages with syngeneic thymocytes resulted in synthesis of a lymphokine which triggered IL-1 production in untreated, peritoneal macrophages.	paraform	13-29	interleukin 1 alpha	Homo sapiens	128-132
7534178-1	1994	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 (IL1) and tumour necrosis factor alpha (TNF alpha) stimulate nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	146-158	interleukin 1 alpha	Homo sapiens	71-84
7534178-1	1994	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 (IL1) and tumour necrosis factor alpha (TNF alpha) stimulate nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	146-158	interleukin 1 alpha	Homo sapiens	86-89
8288885-2	1994	In contrast to mature T cells or the Jurkat cell line, PER-117 cells require interleukin-1 (IL-1) for optimal IL-2 secretion, in addition to calcium ionophore and phorbol 12-myristate 12-acetate (PMA).	Tetradecanoylphorbol Acetate	196-199	interleukin 1 alpha	Homo sapiens	92-96
8073838-5	1994	On the basis of these data we hypothesize that, besides epidermal keratinocytes, another target for Calcipotriol may be the skin"s own immune system, suggesting that Calcipotriol can modify T lymphocyte activity (IL-1 dependent) through a down-regulation of CAMs.	calcipotriene	166-178	interleukin 1 alpha	Homo sapiens	213-217
7994374-10	1994	LMWHb generated a similar increase in TNF, but also a decrease in IL-1.	lmwhb	0-5	interleukin 1 alpha	Homo sapiens	66-70
8287594-7	1994	The ability of the RPM to degrade IC was remarkably enhanced by the pretreatment with HUT102 cell products and the related human recombinant cytokines, lymphotoxin and IL-1 alpha.	Sirolimus	19-22	interleukin 1 alpha	Homo sapiens	168-178
8003632-4	1994	Levels of IL-6 resulting from OM and IL-1 alpha stimulation could be reduced by indomethacin (10(-6) M) and restored again by also adding PGE2.	Indomethacin	80-92	interleukin 1 alpha	Homo sapiens	37-47
8003629-9	1994	Recombinant, human IL-1 (rhIL-1) was shown to prime haemocytes from both resistant snail strains for superoxide production, but had no effect on haemocytes from susceptible B. glabrata.	Superoxides	101-111	interleukin 1 alpha	Homo sapiens	19-23
8306483-6	1994	gamma-interferon, tumour necrosis factor and interleukin-1 stimulated glycosaminoglycan synthesis; this effect was greater in orbital than in dermal fibroblasts with gamma-interferon and interleukin-1 (P &lt; 0.05).	Glycosaminoglycans	70-87	interleukin 1 alpha	Homo sapiens	45-58
8306483-6	1994	gamma-interferon, tumour necrosis factor and interleukin-1 stimulated glycosaminoglycan synthesis; this effect was greater in orbital than in dermal fibroblasts with gamma-interferon and interleukin-1 (P &lt; 0.05).	Glycosaminoglycans	70-87	interleukin 1 alpha	Homo sapiens	187-200
8003632-4	1994	Levels of IL-6 resulting from OM and IL-1 alpha stimulation could be reduced by indomethacin (10(-6) M) and restored again by also adding PGE2.	Dinoprostone	138-142	interleukin 1 alpha	Homo sapiens	37-47
8124729-7	1994	Cytokines, particularly interleukin-1 (IL-1) and IL-6, act as endogenous pyrogens in the brain and stimulate thermogenesis via synthesis of prostaglandins and CRF.	Prostaglandins	140-154	interleukin 1 alpha	Homo sapiens	39-43
8003637-0	1994	Low-dose dietary L-arginine increases plasma interleukin 1 alpha but not interleukin 1 beta in patients with diabetes mellitus.	Arginine	17-27	interleukin 1 alpha	Homo sapiens	45-64
8003637-4	1994	Arginine supplementation in 29 patients with diabetes mellitus prompted a 2-fold increase of IL-1 alpha from baseline levels (P &lt; 0.001) while IL-1 beta was unaffected.	Arginine	0-8	interleukin 1 alpha	Homo sapiens	93-103
8125795-2	1994	IL-1 stimulates the activation and differentiation of pre-B cells and T cells, chemotaxis of neutrophils, recruitment of bone marrow stem cells, stimulation of arachidonic acid metabolism, degradation of proteoglycans, and increase in basal body temperature.	Arachidonic Acid	160-176	interleukin 1 alpha	Homo sapiens	0-4
7531991-4	1994	Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression.	Hydrocortisone	35-49	interleukin 1 alpha	Homo sapiens	68-72
8154300-0	1994	Acridinium ester labelled cytokines: receptor binding studies with human interleukin-1 alpha, interleukin-1 beta and interferon-gamma.	9-Phenylcarboxylate-10-methylacridinium	0-16	interleukin 1 alpha	Homo sapiens	73-92
8199456-2	1994	Incubation of endothelial cells (EC) with interleukin-1 alpha (IL-1 alpha), in contrast to incubation with interferon gamma or tumor necrosis factor alpha, resulted in an enhanced IgG AEA binding.	anandamide	184-187	interleukin 1 alpha	Homo sapiens	42-61
8199456-2	1994	Incubation of endothelial cells (EC) with interleukin-1 alpha (IL-1 alpha), in contrast to incubation with interferon gamma or tumor necrosis factor alpha, resulted in an enhanced IgG AEA binding.	anandamide	184-187	interleukin 1 alpha	Homo sapiens	63-73
8199456-4	1994	The upregulation of IgG-AEA-binding reactivity to IL-1 alpha-stimulated EC was due to binding to antigens that were already expressed by unstimulated EC.	anandamide	24-27	interleukin 1 alpha	Homo sapiens	50-60
8054512-0	1994	Recombinant human interleukin-1 alpha: a potent bio-immunomodifier in vivo in immunosuppressed mice induced by cyclophosphamide, retroviral infection and surgical stress.	Cyclophosphamide	111-127	interleukin 1 alpha	Homo sapiens	18-37
8054512-1	1994	Recombinant human Interleukin-1 Alpha (rhu IL-1 alpha) was assessed for its efficacy in modifying the immunosuppression of mice compromised by Cyclophosphamide (CY), retrovirus infection or surgical stress.	Cyclophosphamide	143-159	interleukin 1 alpha	Homo sapiens	18-37
8054512-1	1994	Recombinant human Interleukin-1 Alpha (rhu IL-1 alpha) was assessed for its efficacy in modifying the immunosuppression of mice compromised by Cyclophosphamide (CY), retrovirus infection or surgical stress.	Cyclophosphamide	143-159	interleukin 1 alpha	Homo sapiens	43-53
8054512-1	1994	Recombinant human Interleukin-1 Alpha (rhu IL-1 alpha) was assessed for its efficacy in modifying the immunosuppression of mice compromised by Cyclophosphamide (CY), retrovirus infection or surgical stress.	Cyclophosphamide	161-163	interleukin 1 alpha	Homo sapiens	18-37
8288917-0	1994	Interleukin-1 increases 15-hydroxyeicosatetraenoic acid production in human dermal fibroblasts.	Eicosatetraenoic acid, 15-hydroxy-	24-55	interleukin 1 alpha	Homo sapiens	0-13
7506711-5	1994	Estradiol also promoted a slight increase in interferon gamma-stimulated endothelial cell adherence for peripheral blood mononuclear cells, but no effect of estradiol was observed when adhesion of leukocytes to endothelial cells was stimulated with IL-1 or IL-4.	Estradiol	0-9	interleukin 1 alpha	Homo sapiens	249-253
7869186-3	1994	In the blood cell cultures of the untreated and sulfasalazine treated patients with Crohn"s disease and ulcerative colitis higher levels of TNF-alpha, IL-1-alpha and IL-1-beta were found whereas IL-2 production was decreased and IFN-gamma-production was not significantly different as compared to the controls.	Sulfasalazine	48-61	interleukin 1 alpha	Homo sapiens	151-161
7505803-0	1994	Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway.	Nitric Oxide	104-116	interleukin 1 alpha	Homo sapiens	0-13
7505803-3	1994	Interleukin 1 (IL-1), tumor necrosis factor (TNF), interferon gamma (IFN-gamma) and Escherichia coli lipopolysaccharide (LPS) increased cGMP at 24 h, whereas IL-2 and IL-6 were ineffective.	Cyclic GMP	136-140	interleukin 1 alpha	Homo sapiens	0-13
7505803-3	1994	Interleukin 1 (IL-1), tumor necrosis factor (TNF), interferon gamma (IFN-gamma) and Escherichia coli lipopolysaccharide (LPS) increased cGMP at 24 h, whereas IL-2 and IL-6 were ineffective.	Cyclic GMP	136-140	interleukin 1 alpha	Homo sapiens	15-19
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	22-58	interleukin 1 alpha	Homo sapiens	14-18
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	22-58	interleukin 1 alpha	Homo sapiens	180-184
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	60-64	interleukin 1 alpha	Homo sapiens	14-18
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	60-64	interleukin 1 alpha	Homo sapiens	180-184
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Methylene Blue	140-154	interleukin 1 alpha	Homo sapiens	14-18
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Methylene Blue	140-154	interleukin 1 alpha	Homo sapiens	180-184
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	6-anilino-5,8-quinolinedione	159-166	interleukin 1 alpha	Homo sapiens	14-18
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	6-anilino-5,8-quinolinedione	159-166	interleukin 1 alpha	Homo sapiens	180-184
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	205-209	interleukin 1 alpha	Homo sapiens	14-18
7505803-4	1994	The effect of IL-1 on cyclic guanosine 3",5"-monophosphate (cGMP) was delayed, occurring after 6 h of exposure, and was maximal after 10 h. Methylene blue and LY83583 reversed the IL-1-induced increase in cGMP, suggesting that it was mediated by activation of soluble guanylate cyclase.	Cyclic GMP	205-209	interleukin 1 alpha	Homo sapiens	180-184
7505803-5	1994	However, IL-1-induced cGMP in HSVSMC was not inhibited by extracellular hemoglobin.	Cyclic GMP	22-26	interleukin 1 alpha	Homo sapiens	9-13
7505803-6	1994	Also, the effect of IL-1 on cGMP was not reversed by nitro- or methyl-substituted L-arginine analogs, aminoguanidine, or diphenyleneiodonium, all of which inhibit IL-1-induced NO synthase in rat aortic VSMC (RAVSMC).	Cyclic GMP	28-32	interleukin 1 alpha	Homo sapiens	20-24
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	Cyclic GMP	13-17	interleukin 1 alpha	Homo sapiens	0-4
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	hsvsmc	21-27	interleukin 1 alpha	Homo sapiens	0-4
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	sapropterin	178-197	interleukin 1 alpha	Homo sapiens	0-4
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	Arginine	231-241	interleukin 1 alpha	Homo sapiens	0-4
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	Arginine	231-241	interleukin 1 alpha	Homo sapiens	0-4
7505803-9	1994	IL-1-induced cGMP was also NO independent in human umbilical artery VSMC, and NO dependent in rat vena cava VSMC.	Cyclic GMP	13-17	interleukin 1 alpha	Homo sapiens	0-4
7507497-8	1994	The synthetic glucocorticoid hormone dexamethasone (DEX) blocks the LPS induction of SP with a Ki approximating 8 x 10(-11) M. The inhibition is due in part to the blockade of the LPS induction of ganglionic IL-1 mRNA.	Dexamethasone	37-50	interleukin 1 alpha	Homo sapiens	208-212
7507497-8	1994	The synthetic glucocorticoid hormone dexamethasone (DEX) blocks the LPS induction of SP with a Ki approximating 8 x 10(-11) M. The inhibition is due in part to the blockade of the LPS induction of ganglionic IL-1 mRNA.	Dexamethasone	52-55	interleukin 1 alpha	Homo sapiens	208-212
7507497-10	1994	The inhibition by indomethacin suggests a non-monocytic cell source since prostaglandins are thought to restrict the LPS induction of monocytic IL-1.	Indomethacin	18-30	interleukin 1 alpha	Homo sapiens	144-148
7507497-10	1994	The inhibition by indomethacin suggests a non-monocytic cell source since prostaglandins are thought to restrict the LPS induction of monocytic IL-1.	Prostaglandins	74-88	interleukin 1 alpha	Homo sapiens	144-148
8288917-3	1994	Interleukin-1 stimulates the production of prostaglandin E2 in fibroblasts, but its effect on the synthesis of 15-HETE is at present unknown.	Dinoprostone	43-59	interleukin 1 alpha	Homo sapiens	0-13
8288917-6	1994	Interleukin-1 significantly increased the production of 15-HETE, but also 12-hydroxy-heptadecatrienoic acid, 11-hydroxyeicosatetraenoic acid, and prostaglandins, in a concentration- and time-dependent fashion.	12-hydroxy-heptadecatrienoic acid	74-107	interleukin 1 alpha	Homo sapiens	0-13
8288917-6	1994	Interleukin-1 significantly increased the production of 15-HETE, but also 12-hydroxy-heptadecatrienoic acid, 11-hydroxyeicosatetraenoic acid, and prostaglandins, in a concentration- and time-dependent fashion.	11R-hydroxy-5E,8Z,12Z,14Z-eicosatetraenoic acid	109-140	interleukin 1 alpha	Homo sapiens	0-13
8288917-6	1994	Interleukin-1 significantly increased the production of 15-HETE, but also 12-hydroxy-heptadecatrienoic acid, 11-hydroxyeicosatetraenoic acid, and prostaglandins, in a concentration- and time-dependent fashion.	Prostaglandins	146-160	interleukin 1 alpha	Homo sapiens	0-13
8288917-8	1994	Dexamethasone (10 nM), and the protein synthesis inhibitors actinomycin D (1 microM) and cycloheximide (3 micrograms/ml) completely abolished the effect of interleukin-1 on 15-HETE formation.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	156-169
8288917-8	1994	Dexamethasone (10 nM), and the protein synthesis inhibitors actinomycin D (1 microM) and cycloheximide (3 micrograms/ml) completely abolished the effect of interleukin-1 on 15-HETE formation.	Dactinomycin	60-73	interleukin 1 alpha	Homo sapiens	156-169
8288917-8	1994	Dexamethasone (10 nM), and the protein synthesis inhibitors actinomycin D (1 microM) and cycloheximide (3 micrograms/ml) completely abolished the effect of interleukin-1 on 15-HETE formation.	Cycloheximide	89-102	interleukin 1 alpha	Homo sapiens	156-169
8288917-8	1994	Dexamethasone (10 nM), and the protein synthesis inhibitors actinomycin D (1 microM) and cycloheximide (3 micrograms/ml) completely abolished the effect of interleukin-1 on 15-HETE formation.	15-Hete	173-180	interleukin 1 alpha	Homo sapiens	156-169
18475594-9	1994	IL-1 of AM origin and PGE(2) of Fb origin secreted at high levels, may be candidates for this suppression because it was abrogated by anti IL-1beta and indomethacin.	Indomethacin	152-164	interleukin 1 alpha	Homo sapiens	0-4
8164509-5	1994	However, under conditions in which THC augmented supernatant IL-1 bioactivity from THP-1 cells, ELISA studies showed that the levels of IL-1 alpha and IL-1 beta were unchanged and decreased, respectively.	Dronabinol	35-38	interleukin 1 alpha	Homo sapiens	136-146
8154008-3	1994	Admission geometric mean venous blood lactate concentrations were almost twice as high in fatal cases as in survivors (7.1 mmol/L vs. 3.6 mmol/L; P &lt; 0.001) and were correlated with levels of tumour necrosis factor (r = 0.42, n = 79; P &lt; 0.0001) and interleukin 1-alpha (r = 0.6, n = 34; P &lt; 0.0001).	Lactic Acid	38-45	interleukin 1 alpha	Homo sapiens	256-275
7787251-1	1994	Recombinant human interleukin-1 alpha (rIL-1 alpha), at concentrations that were not growth-inhibitory when given alone (100-10,000 U/ml), enhanced the growth inhibition resulting from a 72-h fluorouracil (FUra) exposure in HCT116 colon cancer cells.	Fluorouracil	192-204	interleukin 1 alpha	Homo sapiens	18-37
7787251-1	1994	Recombinant human interleukin-1 alpha (rIL-1 alpha), at concentrations that were not growth-inhibitory when given alone (100-10,000 U/ml), enhanced the growth inhibition resulting from a 72-h fluorouracil (FUra) exposure in HCT116 colon cancer cells.	Fluorouracil	206-210	interleukin 1 alpha	Homo sapiens	18-37
8190832-7	1994	Administration of IL-1 produces a long-lasting increase in corticosterone.	Corticosterone	59-73	interleukin 1 alpha	Homo sapiens	18-22
8190832-1	1994	Interleukin-1 (IL-1) and interleukin-6 (IL-6), and their cognate receptors, are expressed in hippocampal neurons, which are targets for corticosteroid hormones.	corticosteroid hormones	136-159	interleukin 1 alpha	Homo sapiens	0-13
8190832-1	1994	Interleukin-1 (IL-1) and interleukin-6 (IL-6), and their cognate receptors, are expressed in hippocampal neurons, which are targets for corticosteroid hormones.	corticosteroid hormones	136-159	interleukin 1 alpha	Homo sapiens	15-19
8142915-1	1994	In vivo, recombinant human interleukin 1 alpha (rHuIL-1 alpha) + recombinant human macrophage colony-stimulating factor (rHuM-CSF) (IL-1 + M-CSF) effectively serves as a rescue agent for myelosuppression by enhancing the recovery of hematopoietic stem cell (HSC) subpopulations following treatment with 5-fluorouracil (5-FU).	Fluorouracil	303-317	interleukin 1 alpha	Homo sapiens	27-46
8142915-1	1994	In vivo, recombinant human interleukin 1 alpha (rHuIL-1 alpha) + recombinant human macrophage colony-stimulating factor (rHuM-CSF) (IL-1 + M-CSF) effectively serves as a rescue agent for myelosuppression by enhancing the recovery of hematopoietic stem cell (HSC) subpopulations following treatment with 5-fluorouracil (5-FU).	Fluorouracil	319-323	interleukin 1 alpha	Homo sapiens	27-46
7505123-3	1993	We have investigated the effect of beta-glucans on the production of interleukin-1 (IL-1) and its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1Ra).	beta-Glucans	35-47	interleukin 1 alpha	Homo sapiens	69-82
7505123-3	1993	We have investigated the effect of beta-glucans on the production of interleukin-1 (IL-1) and its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1Ra).	beta-Glucans	35-47	interleukin 1 alpha	Homo sapiens	84-88
7505123-9	1993	Because of their differential effects on cytokine production, beta-glucans may be used to therapeutic advantage in the diseases in which IL-1 is implicated.	beta-Glucans	62-74	interleukin 1 alpha	Homo sapiens	137-141
8267584-4	1993	IL-4 (10 ng/ml) alone did not affect prostaglandin E2 (PGE2) synthesis by mesangial cells, though, it inhibited IL-1 alpha- and TNF alpha-stimulated PGE2 synthesis by 48% and 81%, respectively.	Dinoprostone	149-153	interleukin 1 alpha	Homo sapiens	112-122
8267584-5	1993	Comparable inhibition was observed on the conversion of exogenous arachidonic acid to PGs by IL-1-stimulated cells, suggesting IL-4 down regulates PG endoperoxide synthase activity.	Arachidonic Acid	66-82	interleukin 1 alpha	Homo sapiens	93-97
8267584-5	1993	Comparable inhibition was observed on the conversion of exogenous arachidonic acid to PGs by IL-1-stimulated cells, suggesting IL-4 down regulates PG endoperoxide synthase activity.	Phosphatidylglycerols	86-89	interleukin 1 alpha	Homo sapiens	93-97
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 alpha	Homo sapiens	0-4
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	321-324	interleukin 1 alpha	Homo sapiens	0-4
8280080-7	1993	Phorbol ester also induced TIMP-1 and MMP-9, the expression of the latter being further enhanced by TNF alpha or interleukin 1 alpha (IL-1 alpha).	Phorbol Esters	0-13	interleukin 1 alpha	Homo sapiens	113-132
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Staurosporine	330-343	interleukin 1 alpha	Homo sapiens	0-4
8268245-3	1993	The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	26-29	interleukin 1 alpha	Homo sapiens	55-59
8268245-3	1993	The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	55-59
8268245-4	1993	When protein kinase C was down-regulated by treating the cells with a high level of TPA, the inductive effect of IL-1 upon proMMP-3 production was reduced considerably.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Homo sapiens	113-117
8268245-7	1993	Both IL-1 and TPA also accelerated the production of prostaglandin E2 (PGE2) by cervical fibroblasts.	Dinoprostone	53-69	interleukin 1 alpha	Homo sapiens	5-9
8268245-7	1993	Both IL-1 and TPA also accelerated the production of prostaglandin E2 (PGE2) by cervical fibroblasts.	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	5-9
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Staurosporine	41-54	interleukin 1 alpha	Homo sapiens	74-78
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 alpha	Homo sapiens	0-4
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	)-2-methylpiperazine dihydrochloride	283-319	interleukin 1 alpha	Homo sapiens	0-4
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Staurosporine	41-54	interleukin 1 alpha	Homo sapiens	171-175
8280080-7	1993	Phorbol ester also induced TIMP-1 and MMP-9, the expression of the latter being further enhanced by TNF alpha or interleukin 1 alpha (IL-1 alpha).	Phorbol Esters	0-13	interleukin 1 alpha	Homo sapiens	134-144
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Dinoprostone	104-108	interleukin 1 alpha	Homo sapiens	74-78
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Dinoprostone	163-167	interleukin 1 alpha	Homo sapiens	74-78
7504060-3	1993	LPS-LPS-binding protein complexes in blood also interact with monocytes and neutrophils bearing glycosyl-phosphatidylinositol (GPI) anchored membrane CD14 (mCD14), promoting the release of cytokines such as tumor necrosis factor and interleukin 1 (IL-1).	Glycosylphosphatidylinositols	96-125	interleukin 1 alpha	Homo sapiens	233-252
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Dinoprostone	163-167	interleukin 1 alpha	Homo sapiens	171-175
8003924-1	1993	We studied the effects of human recombinant interleukin-1 alpha on scopolamine-induced amnesia for a passive avoidance response in the mouse.	Scopolamine	67-78	interleukin 1 alpha	Homo sapiens	44-63
8131794-1	1993	In an attempt to understand more directly the molecular mechanisms involved in the cellular response of endothelial cells to Interleukin-1 (IL-1), we have made several cDNA libraries from human umbilical vein endothelial cells (HUVEC) stimulated for 1 h with IL-1 in the presence of cycloheximide.	Cycloheximide	283-296	interleukin 1 alpha	Homo sapiens	140-144
7504060-3	1993	LPS-LPS-binding protein complexes in blood also interact with monocytes and neutrophils bearing glycosyl-phosphatidylinositol (GPI) anchored membrane CD14 (mCD14), promoting the release of cytokines such as tumor necrosis factor and interleukin 1 (IL-1).	Glycosylphosphatidylinositols	127-130	interleukin 1 alpha	Homo sapiens	233-252
8186370-6	1993	Using digoxigenin-labelled oligonucleotide probes we have detected expression of the cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TGF beta 1 &amp; 2 and TNF-alpha in frozen sections of CNS tissue from MS cases.	Digoxigenin	6-17	interleukin 1 alpha	Homo sapiens	95-105
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	222-226	interleukin 1 alpha	Homo sapiens	0-13
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	222-226	interleukin 1 alpha	Homo sapiens	15-19
8140119-6	1993	IL-1 or TNF in combination with EGF or TGF-alpha stimulated synergistically the production of PGE2 by amnion cells.	Dinoprostone	94-98	interleukin 1 alpha	Homo sapiens	0-4
8140119-10	1993	The potentiation of the PGE2-stimulatory effect of IL-1 by TGF-alpha may be related to its ability to induce IL-1 receptors on amnion cells.	Dinoprostone	24-28	interleukin 1 alpha	Homo sapiens	51-55
8140119-10	1993	The potentiation of the PGE2-stimulatory effect of IL-1 by TGF-alpha may be related to its ability to induce IL-1 receptors on amnion cells.	Dinoprostone	24-28	interleukin 1 alpha	Homo sapiens	109-113
8226870-4	1993	A 35S-labeled protein doublet with a molecular mass of approximately 70,000 daltons was immunoprecipitated with the anti-Cox-2 antiserum in L-[35S] methionine-labeled cells stimulated with interleukin 1 alpha.	l-[35s] methionine	140-158	interleukin 1 alpha	Homo sapiens	189-208
8186370-6	1993	Using digoxigenin-labelled oligonucleotide probes we have detected expression of the cytokines IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TGF beta 1 &amp; 2 and TNF-alpha in frozen sections of CNS tissue from MS cases.	Oligonucleotides	27-42	interleukin 1 alpha	Homo sapiens	95-105
8140119-0	1993	Epidermal growth factor and transforming growth factor-alpha enhance the interleukin-1- and tumor necrosis factor-stimulated prostaglandin E2 production and the interleukin-1 specific binding on amnion cells.	Dinoprostone	125-141	interleukin 1 alpha	Homo sapiens	73-113
8140119-0	1993	Epidermal growth factor and transforming growth factor-alpha enhance the interleukin-1- and tumor necrosis factor-stimulated prostaglandin E2 production and the interleukin-1 specific binding on amnion cells.	Dinoprostone	125-141	interleukin 1 alpha	Homo sapiens	73-86
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	141-157	interleukin 1 alpha	Homo sapiens	0-13
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	141-157	interleukin 1 alpha	Homo sapiens	15-19
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	159-163	interleukin 1 alpha	Homo sapiens	0-13
8140119-1	1993	Interleukin-1 (IL-1), tumor necrosis factor (TNF), epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) stimulate prostaglandin E2 (PGE2) production by amnion cells whereas TGF-beta inhibits the PGE2 production.	Dinoprostone	159-163	interleukin 1 alpha	Homo sapiens	15-19
8118428-0	1993	Development of neoglycoproteins conjugated with natural oligosaccharides through carboxyl residues of proteins and its application to recombinant human interleukin 1.	Oligosaccharides	56-72	interleukin 1 alpha	Homo sapiens	152-165
8118428-6	1993	While this strategy was applied to recombinant human interleukin 1 alpha (IL-1 alpha), three molecules of oligosaccharide-Asns were introduced into per molecule of IL-1 with 10% yield of glycosylation.	oligosaccharide-asns	106-126	interleukin 1 alpha	Homo sapiens	53-72
8131967-0	1993	The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.	Sulfhydryl Compounds	15-20	interleukin 1 alpha	Homo sapiens	66-79
8225873-9	1993	When added together, dexamethasone antagonizes the interleukin-1 alpha-induced increase of stromelysin, gelatinase B, and TIMP1 in a dose-dependent manner.	Dexamethasone	21-34	interleukin 1 alpha	Homo sapiens	51-70
8228619-0	1993	Silica induces apoptosis in macrophages and the release of interleukin-1 alpha and interleukin-1 beta.	Silicon Dioxide	0-6	interleukin 1 alpha	Homo sapiens	59-78
8077304-1	1993	Interleukin-1 (IL-1), a potent stimulant of bone resorption, has been implicated in the pathogenesis of postmenopausal osteoporosis, because monocyte IL-1 bioactivity increases after the menopause and is decreased by estrogen and progesterone (EP) replacement.	Progesterone	230-242	interleukin 1 alpha	Homo sapiens	0-13
8077304-1	1993	Interleukin-1 (IL-1), a potent stimulant of bone resorption, has been implicated in the pathogenesis of postmenopausal osteoporosis, because monocyte IL-1 bioactivity increases after the menopause and is decreased by estrogen and progesterone (EP) replacement.	Progesterone	230-242	interleukin 1 alpha	Homo sapiens	15-19
8228619-2	1993	The use of anti-IL-1 antisera showed that both IL-1 alpha and IL-1 beta were present in supernatants of silica-treated macrophages.	Silicon Dioxide	104-110	interleukin 1 alpha	Homo sapiens	47-57
8216333-4	1993	3-Morpholino-sydnonimine (SIN-1) enhanced IL-1 alpha-induced TNF synthesis to a maximum of 272% (mean of n = 5 donors), with 100% set as TNF production by stimulation with IL-1 alpha alone.	linsidomine	0-24	interleukin 1 alpha	Homo sapiens	42-52
8275306-4	1993	ATA decreased both steady state and interleukin-1 (IL1)-induced increase in beta-APP mRNA levels.	Aurintricarboxylic Acid	0-3	interleukin 1 alpha	Homo sapiens	36-49
8275306-4	1993	ATA decreased both steady state and interleukin-1 (IL1)-induced increase in beta-APP mRNA levels.	Aurintricarboxylic Acid	0-3	interleukin 1 alpha	Homo sapiens	51-54
7694584-4	1993	We found that dexamethasone (4-40 micrograms/mL), the azathioprine metabolite 6-mercaptopurine (10-100 micrograms/mL) and cyclosporine A (0.1-1 microgram/mL) have no effect on the basal and the tumor necrosis factor-alpha- or interleukin-1-stimulated expression of these adhesion molecules.	Azathioprine	54-66	interleukin 1 alpha	Homo sapiens	226-239
7694584-4	1993	We found that dexamethasone (4-40 micrograms/mL), the azathioprine metabolite 6-mercaptopurine (10-100 micrograms/mL) and cyclosporine A (0.1-1 microgram/mL) have no effect on the basal and the tumor necrosis factor-alpha- or interleukin-1-stimulated expression of these adhesion molecules.	Cyclosporine	122-136	interleukin 1 alpha	Homo sapiens	226-239
8216333-4	1993	3-Morpholino-sydnonimine (SIN-1) enhanced IL-1 alpha-induced TNF synthesis to a maximum of 272% (mean of n = 5 donors), with 100% set as TNF production by stimulation with IL-1 alpha alone.	linsidomine	0-24	interleukin 1 alpha	Homo sapiens	172-182
7691802-7	1993	Inhibition of PTKs by herbimycin A completely blocks LPS-induced down-modulation of CD14 and production of TNF-alpha and IL-1.	herbimycin	22-34	interleukin 1 alpha	Homo sapiens	121-125
8408074-2	1993	Autoradiographs of the membranes revealed an 85-kDa 32P-labeled band; the intensity of this band was transiently increased in nuclear but not in cytosolic extracts from interleukin-1 alpha-treated cells.	Phosphorus-32	52-55	interleukin 1 alpha	Homo sapiens	169-188
8408074-3	1993	Incorporation of 32P label into a blotted protein band suggested the presence of an interleukin-1 alpha-responsive 85-kDa nuclear protein kinase.	Phosphorus-32	17-20	interleukin 1 alpha	Homo sapiens	84-103
7691110-6	1993	The TNF alpha/IL-1-stimulated GM-CSF release was blocked by the addition of 1 microM dexamethasone, whereas basal CSF-1 release was unaffected.	Dexamethasone	85-98	interleukin 1 alpha	Homo sapiens	14-18
8238136-0	1993	Interleukin-1 and tumor necrosis factor stimulate arachidonic acid release and phospholipid metabolism in human myometrial cells.	Arachidonic Acid	50-66	interleukin 1 alpha	Homo sapiens	0-39
8238136-0	1993	Interleukin-1 and tumor necrosis factor stimulate arachidonic acid release and phospholipid metabolism in human myometrial cells.	Phospholipids	79-91	interleukin 1 alpha	Homo sapiens	0-39
8238136-1	1993	OBJECTIVE: Our aim was to evaluate the effects of the cytokines interleukin-1 and tumor necrosis factor on arachidonic acid release in human myometrial cells.	Arachidonic Acid	107-123	interleukin 1 alpha	Homo sapiens	64-103
8238136-8	1993	In addition, interleukin-1 also increased the loss of arachidonic acid from phosphatidic acid and significantly potentiated the oxytocin-evoked myometrial contractility.	Arachidonic Acid	54-70	interleukin 1 alpha	Homo sapiens	13-26
8238136-8	1993	In addition, interleukin-1 also increased the loss of arachidonic acid from phosphatidic acid and significantly potentiated the oxytocin-evoked myometrial contractility.	Phosphatidic Acids	76-93	interleukin 1 alpha	Homo sapiens	13-26
8238136-9	1993	CONCLUSIONS: Both interleukin-1 and tumor necrosis factor enhance arachidonic acid release, probably by inducing the synthesis of phospholipase A2 and possibly other enzymes involved in the metabolism of phospholipids.	Arachidonic Acid	66-82	interleukin 1 alpha	Homo sapiens	18-57
8238136-9	1993	CONCLUSIONS: Both interleukin-1 and tumor necrosis factor enhance arachidonic acid release, probably by inducing the synthesis of phospholipase A2 and possibly other enzymes involved in the metabolism of phospholipids.	Phospholipids	204-217	interleukin 1 alpha	Homo sapiens	18-57
8221116-0	1993	Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.	Lithium Chloride	63-79	interleukin 1 alpha	Homo sapiens	0-13
8286511-7	1993	The incorporation of D-(U-14C) glucose into triacylglycerol and free fatty acids was significantly stimulated by TNF-alpha and IL-1, but not by IL-6.	d-(u-14c) glucose	21-38	interleukin 1 alpha	Homo sapiens	127-131
8292668-11	1993	Our results demonstrate that methotrexate blocks the interleukin 1 beta-interleukin 1 receptor pathway.	Methotrexate	29-41	interleukin 1 alpha	Homo sapiens	53-66
8292668-12	1993	Methotrexate is therefore another interleukin 1 inhibitor and a clinically efficient anticytokine.	Methotrexate	0-12	interleukin 1 alpha	Homo sapiens	34-47
8286511-5	1993	MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes.	Triglycerides	111-126	interleukin 1 alpha	Homo sapiens	59-63
8286511-7	1993	The incorporation of D-(U-14C) glucose into triacylglycerol and free fatty acids was significantly stimulated by TNF-alpha and IL-1, but not by IL-6.	Triglycerides	44-59	interleukin 1 alpha	Homo sapiens	127-131
8286511-5	1993	MAIN OUTCOME MEASURES: Effect of TNF-alpha, interleukin-1 (IL-1), and interleukin-6 (IL-6) on the synthesis of triacylglycerol and phospholipids by freshly isolated human hepatocytes.	Phospholipids	131-144	interleukin 1 alpha	Homo sapiens	59-63
8286511-7	1993	The incorporation of D-(U-14C) glucose into triacylglycerol and free fatty acids was significantly stimulated by TNF-alpha and IL-1, but not by IL-6.	Fatty Acids, Nonesterified	64-80	interleukin 1 alpha	Homo sapiens	127-131
8292668-0	1993	Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells.	Methotrexate	23-35	interleukin 1 alpha	Homo sapiens	99-112
8292668-0	1993	Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells.	Methotrexate	64-76	interleukin 1 alpha	Homo sapiens	99-112
8292668-5	1993	It has been demonstrated that methotrexate has no influence on the interleukin 1 synthesis, so we focused our attention on the ability of methotrexate to interfere with the binding of interleukin 1 beta to the interleukin 1 receptor.	Methotrexate	138-150	interleukin 1 alpha	Homo sapiens	184-197
8292668-7	1993	Methotrexate led to an astonishing decrease in the binding of interleukin 1 beta to the interleukin 1 receptor of peripheral blood cells, whereas methylprednisolone and indomethacin were not inhibitory.	Methotrexate	0-12	interleukin 1 alpha	Homo sapiens	62-75
8360185-9	1993	However, experiments with actinomycin D demonstrated that IL-1 significantly increased the half-life of the PN-1 mRNA.	Dactinomycin	26-39	interleukin 1 alpha	Homo sapiens	58-62
8256659-1	1993	Recombinant human interleukin-1 (rhIL-1) can induce an elevation in calcium that has been ascribed exclusively to the stimulation of bone resorption.	Calcium	68-75	interleukin 1 alpha	Homo sapiens	18-39
8409518-1	1993	Stimulation of cultured human keratinocytes with interleukin (IL)-1 alpha is known to elicit prostaglandin (PG) E2 release.	Dinoprostone	93-114	interleukin 1 alpha	Homo sapiens	49-73
8114468-4	1993	METHODS: Since interleukin-1 (IL-1) promotes secretion of prostaglandin E-2 (PG-E2 and collagenase, we were interested in the number of membrane receptors for these cytokines on keratoconus fibroblasts and determined the corresponding dissociation constant (kD).	Dinoprostone	58-75	interleukin 1 alpha	Homo sapiens	15-28
8114468-4	1993	METHODS: Since interleukin-1 (IL-1) promotes secretion of prostaglandin E-2 (PG-E2 and collagenase, we were interested in the number of membrane receptors for these cytokines on keratoconus fibroblasts and determined the corresponding dissociation constant (kD).	Dinoprostone	58-75	interleukin 1 alpha	Homo sapiens	30-34
8114468-4	1993	METHODS: Since interleukin-1 (IL-1) promotes secretion of prostaglandin E-2 (PG-E2 and collagenase, we were interested in the number of membrane receptors for these cytokines on keratoconus fibroblasts and determined the corresponding dissociation constant (kD).	Dinoprostone	77-82	interleukin 1 alpha	Homo sapiens	15-28
8114468-4	1993	METHODS: Since interleukin-1 (IL-1) promotes secretion of prostaglandin E-2 (PG-E2 and collagenase, we were interested in the number of membrane receptors for these cytokines on keratoconus fibroblasts and determined the corresponding dissociation constant (kD).	Dinoprostone	77-82	interleukin 1 alpha	Homo sapiens	30-34
8114468-12	1993	If IL-1 is added to the incubation medium, which contains [3H]-labeled arachidonic acid, PG-E2 synthesis increases more than in normal corneal cells.	Tritium	59-61	interleukin 1 alpha	Homo sapiens	3-7
8114468-12	1993	If IL-1 is added to the incubation medium, which contains [3H]-labeled arachidonic acid, PG-E2 synthesis increases more than in normal corneal cells.	Arachidonic Acid	71-87	interleukin 1 alpha	Homo sapiens	3-7
8114468-12	1993	If IL-1 is added to the incubation medium, which contains [3H]-labeled arachidonic acid, PG-E2 synthesis increases more than in normal corneal cells.	Dinoprostone	89-94	interleukin 1 alpha	Homo sapiens	3-7
8376361-2	1993	Signal transduction for tumor necrosis factor-alpha and interleukin-1 involves sphingomyelin hydrolysis to ceramide and stimulation of a ceramide-activated serine/threonine protein kinase (Mathias, S., Younes, A., Kan, C., Orlow, I., Joseph, C., and Kolesnick, R. (1993) Science 259, 519-522).	Sphingomyelins	79-92	interleukin 1 alpha	Homo sapiens	56-69
8376361-2	1993	Signal transduction for tumor necrosis factor-alpha and interleukin-1 involves sphingomyelin hydrolysis to ceramide and stimulation of a ceramide-activated serine/threonine protein kinase (Mathias, S., Younes, A., Kan, C., Orlow, I., Joseph, C., and Kolesnick, R. (1993) Science 259, 519-522).	Ceramides	107-115	interleukin 1 alpha	Homo sapiens	56-69
8311930-4	1993	RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production.	Cyclic AMP	188-192	interleukin 1 alpha	Homo sapiens	117-121
8311930-4	1993	RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production.	Colforsin	235-244	interleukin 1 alpha	Homo sapiens	117-121
8311930-4	1993	RESULTS: HMC were found to specifically bind [125I]IL-1 with an apparent Kd of 2 x 10(-10) M. Incubation of HMC with IL-1 or TNF caused a time-dependent and dose-dependent accumulation of cAMP, as well as a significant potentiation of forskolin-promoted cAMP production.	Cyclic AMP	254-258	interleukin 1 alpha	Homo sapiens	117-121
8311930-7	1993	CONCLUSIONS: It is suggested that IL-1 and TNF may activate one or more isoforms of the catalytic component of adenylyl cyclase, raising intracellular cAMP.	Cyclic AMP	151-155	interleukin 1 alpha	Homo sapiens	34-38
8237476-4	1993	Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner.	Titanium	14-22	interleukin 1 alpha	Homo sapiens	154-158
8371761-1	1993	Inducible gene expression in eukaryotes is mainly controlled by the activity of transcriptional activator proteins, such as NF-kappa B (refs 1-3), a factor activated upon treatment of cells with phorbol esters, lipopolysaccharide, interleukin-1 and tumour necrosis factor-alpha.	Phorbol Esters	195-209	interleukin 1 alpha	Homo sapiens	231-277
8142610-2	1993	Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury.	Bleomycin	120-129	interleukin 1 alpha	Homo sapiens	41-53
8237476-4	1993	Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner.	Polymethyl Methacrylate	28-50	interleukin 1 alpha	Homo sapiens	154-158
8237476-4	1993	Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner.	Polystyrenes	62-73	interleukin 1 alpha	Homo sapiens	154-158
8237476-4	1993	Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner.	Phosphorus	75-77	interleukin 1 alpha	Homo sapiens	154-158
8237476-8	1993	Exogenous PGE2 and recombinant human IL-1 could significantly increase the 45Ca release; indomethacin (IM) significantly reduced both the spontaneous calcium efflux and active 45Ca release from in vivo labeled calvarial bones.	Calcium	150-157	interleukin 1 alpha	Homo sapiens	37-41
8248272-2	1993	HUVEC which had been preincubated with LPS, interleukin-1 alpha (IL-1 alpha), IL-1 beta, tumor necrosis factor (TNF alpha), or interferon-gamma (IFN-gamma) produced more PGI2 than control cells in response to thrombin.	Epoprostenol	170-174	interleukin 1 alpha	Homo sapiens	44-63
8246834-7	1993	Indomethacin partially prevented the IL-1 alpha + EGF-induced increase in enzyme release, suggesting the involvement of prostaglandins.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	37-47
8246834-7	1993	Indomethacin partially prevented the IL-1 alpha + EGF-induced increase in enzyme release, suggesting the involvement of prostaglandins.	Prostaglandins	120-134	interleukin 1 alpha	Homo sapiens	37-47
8230718-0	1993	[Effects of DbcAMP on tumor necrosis factor and interleukin-1 production in human monocytes].	Bucladesine	12-18	interleukin 1 alpha	Homo sapiens	48-61
8230718-2	1993	To determine whether DbcAMP suppresses the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in human monocytes, we measured the levels of TNF and IL-1 in response to E. Coli lipopolysaccharide (40 micrograms.ml-1) in vitro.	Bucladesine	21-27	interleukin 1 alpha	Homo sapiens	89-108
8230718-2	1993	To determine whether DbcAMP suppresses the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in human monocytes, we measured the levels of TNF and IL-1 in response to E. Coli lipopolysaccharide (40 micrograms.ml-1) in vitro.	Bucladesine	21-27	interleukin 1 alpha	Homo sapiens	104-108
8248272-2	1993	HUVEC which had been preincubated with LPS, interleukin-1 alpha (IL-1 alpha), IL-1 beta, tumor necrosis factor (TNF alpha), or interferon-gamma (IFN-gamma) produced more PGI2 than control cells in response to thrombin.	Epoprostenol	170-174	interleukin 1 alpha	Homo sapiens	65-75
8356399-3	1993	We found that hydrocortisone stimulated cell proliferation but inhibited the differentiation of TEC and significantly reduced the production of interleukin-1 alpha, interleukin-6 and granulocyte-macrophage colony stimulating factor.	Hydrocortisone	14-28	interleukin 1 alpha	Homo sapiens	144-163
7688736-6	1993	Using gel retardation and transient expression assays, we show that IL-1 causes protein tyrosine phosphorylation-dependent activation of NF-kappa B enhancer binding protein, which then induces transcription of the gro-genes via an NF-kappa B site located 76 base pairs upstream from the cap site.	Tyrosine	88-96	interleukin 1 alpha	Homo sapiens	68-72
7688736-7	1993	IL-1-activated protein tyrosine phosphorylation is also required for gro-gene induction in human cervical carcinoma cells, HeLa; human fibroblast cells, WI-38; and mouse fibroblast cells, L929.	Tyrosine	23-31	interleukin 1 alpha	Homo sapiens	0-4
8353136-0	1993	Regulation of hyaluronate production by interleukin 1 in cultured human chorionic cells.	hyaluronate	14-25	interleukin 1 alpha	Homo sapiens	40-53
8363610-0	1993	Inhibition of DNA repair and sensitization of cisplatin in human ovarian carcinoma cells by interleukin-1 alpha.	Cisplatin	46-55	interleukin 1 alpha	Homo sapiens	92-111
8363610-1	1993	Interleukin-1 alpha induced an increase in both the cellular accumulation of cis-diamminedichloroplatinum (II) (cisplatin) and DNA platination and significantly reduced the removal of platinum from DNA of human ovarian (NIH: OVCAR-3) carcinoma cells in culture.	Cisplatin	77-105	interleukin 1 alpha	Homo sapiens	0-19
8363610-1	1993	Interleukin-1 alpha induced an increase in both the cellular accumulation of cis-diamminedichloroplatinum (II) (cisplatin) and DNA platination and significantly reduced the removal of platinum from DNA of human ovarian (NIH: OVCAR-3) carcinoma cells in culture.	Cisplatin	112-121	interleukin 1 alpha	Homo sapiens	0-19
8363610-1	1993	Interleukin-1 alpha induced an increase in both the cellular accumulation of cis-diamminedichloroplatinum (II) (cisplatin) and DNA platination and significantly reduced the removal of platinum from DNA of human ovarian (NIH: OVCAR-3) carcinoma cells in culture.	Platinum	97-105	interleukin 1 alpha	Homo sapiens	0-19
8363610-2	1993	The combinations of IL-1 alpha and cisplatin were highly synergistic against these ovarian carcinoma cells and maximum levels of sensitization (15-20-fold) were observed during simultaneous exposure of cisplatin and IL-1 alpha.	Cisplatin	35-44	interleukin 1 alpha	Homo sapiens	216-226
8363610-2	1993	The combinations of IL-1 alpha and cisplatin were highly synergistic against these ovarian carcinoma cells and maximum levels of sensitization (15-20-fold) were observed during simultaneous exposure of cisplatin and IL-1 alpha.	Cisplatin	202-211	interleukin 1 alpha	Homo sapiens	20-30
8363610-4	1993	These results strongly indicate that IL-1 alpha inhibits DNA repair, and this inhibition of DNA repair may explain, in part, a strong synergistic interaction between IL-1 alpha and cisplatin in NIH: OVCAR-3 cells.	Cisplatin	181-190	interleukin 1 alpha	Homo sapiens	37-47
8353136-2	1993	When these cells were treated with human recombinant interleukin 1 alpha (hrIL-1), the biosynthesis and secretion of hyaluronate were predominantly accelerated, but those of sulfated glycosaminoglycans were not modulated.	hyaluronate	117-128	interleukin 1 alpha	Homo sapiens	53-72
8353136-2	1993	When these cells were treated with human recombinant interleukin 1 alpha (hrIL-1), the biosynthesis and secretion of hyaluronate were predominantly accelerated, but those of sulfated glycosaminoglycans were not modulated.	Glycosaminoglycans	183-201	interleukin 1 alpha	Homo sapiens	53-72
8354887-8	1993	To monitor the reliability and reproducibility of this method, we followed the adherence of Calcein AM-labeled THP-1 cells, a human monocytic cell line, to human endothelial cells treated with interleukin-1.	calcein AM	92-102	interleukin 1 alpha	Homo sapiens	193-206
8347686-6	1993	Actinomycin D and cycloheximide inhibited both the basal and IL-1 alpha-induced production of M-CSF, suggesting a requirement for de novo RNA and protein synthesis.	Dactinomycin	0-13	interleukin 1 alpha	Homo sapiens	61-71
8347686-6	1993	Actinomycin D and cycloheximide inhibited both the basal and IL-1 alpha-induced production of M-CSF, suggesting a requirement for de novo RNA and protein synthesis.	Cycloheximide	18-31	interleukin 1 alpha	Homo sapiens	61-71
7504450-6	1993	An autocrine IL-1-dependent mechanism mediating NiCl2 effects could be excluded.	nickel chloride	48-53	interleukin 1 alpha	Homo sapiens	13-17
8105984-3	1993	It seems likely that the aminosalicylates are important free radical scavengers, can reduce leukotriene production and can inhibit the cellular release of interleukin-1, all of which are likely to be important in reducing the acute inflammatory response in inflammatory bowel disease.	Aminosalicylic Acid	25-41	interleukin 1 alpha	Homo sapiens	155-168
8368330-7	1993	Prostaglandin E2 inhibits Na(+)-K(+)-ATPase and appears to mediate the actions of several peptide hormones, including endothelin, interleukin-1, and atrial natriuretic peptide [ANP-(31-67)].	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	130-143
8377379-10	1993	The effect of rapamycin on the IL-1 alpha enhanced TNF alpha production differed from the effect of CsA.	Sirolimus	14-23	interleukin 1 alpha	Homo sapiens	31-41
8225400-6	1993	When fibroblasts were pretreated with cyclohexamide prior to stimulation the level of induction by LPS and IL-1 alpha increased dramatically and peak levels were observed at 5 h post-stimulation.	4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione	38-51	interleukin 1 alpha	Homo sapiens	107-117
8334682-5	1993	Enhanced expression of IL-1 alpha and IL-1 beta mRNA was inhibited at 4 h but not 24 h when monocytes were incubated with L-MTP-PE plus anti-TNF compared with L-MTP-PE alone.	L-MTP-PE	122-130	interleukin 1 alpha	Homo sapiens	23-33
8334682-5	1993	Enhanced expression of IL-1 alpha and IL-1 beta mRNA was inhibited at 4 h but not 24 h when monocytes were incubated with L-MTP-PE plus anti-TNF compared with L-MTP-PE alone.	L-MTP-PE	159-167	interleukin 1 alpha	Homo sapiens	23-33
7505000-3	1993	The expression of tumour necrosis factor (TNF)alpha, TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose-dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX.	Pentoxifylline	124-127	interleukin 1 alpha	Homo sapiens	178-188
8354727-4	1993	While both therapies improved clinical parameters of periodontal disease, IL-1 alpha concentration increased significantly (p &lt; 0.05) in M/AP-PFD sites 6 months after treatment, but were unchanged in other groups.	ap-pfd	142-148	interleukin 1 alpha	Homo sapiens	74-84
8377379-4	1993	The presence of cyclosporin A (CsA) during stimulation with IL-1 alpha inhibited the enhanced TNF alpha production in a dose dependent fashion, with a maximal inhibition of 90% at a concentration of 250 ng/ml.	Cyclosporine	31-34	interleukin 1 alpha	Homo sapiens	60-70
8411796-11	1993	When cyclosporine A is used in combination with prednisone, the immunologic cycle that causes rejection is interrupted twice by virtue of the fact that prednisone prevents the production of IL-1 by macrophages and cyclosporine A with the production of lymphokines, especially IL-2 (T-cell growth factor).	Cyclosporine	5-19	interleukin 1 alpha	Homo sapiens	190-194
8218592-7	1993	The selective PKC inhibitor, Ro 31-7549, augmented IL-1-induced inhibition of hair follicle growth, but did not itself affect hair follicle growth.	Ro 31-7549	29-39	interleukin 1 alpha	Homo sapiens	51-55
8411796-11	1993	When cyclosporine A is used in combination with prednisone, the immunologic cycle that causes rejection is interrupted twice by virtue of the fact that prednisone prevents the production of IL-1 by macrophages and cyclosporine A with the production of lymphokines, especially IL-2 (T-cell growth factor).	Prednisone	48-58	interleukin 1 alpha	Homo sapiens	190-194
8411796-11	1993	When cyclosporine A is used in combination with prednisone, the immunologic cycle that causes rejection is interrupted twice by virtue of the fact that prednisone prevents the production of IL-1 by macrophages and cyclosporine A with the production of lymphokines, especially IL-2 (T-cell growth factor).	Prednisone	152-162	interleukin 1 alpha	Homo sapiens	190-194
8210444-6	1993	IL-2 enhanced the stimulatory actions of interleukin-1 (IL-1), epidermal growth factor (EGF), ionomycin, and phorbol 12-myristate 13-acetate (PMA) on PGE2 production by decidual cells.	Dinoprostone	150-154	interleukin 1 alpha	Homo sapiens	56-60
8317554-5	1993	Both manganese SOD and copper, zinc SOD activities were significantly induced by paraquat, interleukin-1, tumor necrosis factor, adriamycin, and bleomycin in lymphocytes and neutrophils from asymptomatic non-aged adults, whereas neither activity was induced in aged individuals.	Copper	23-29	interleukin 1 alpha	Homo sapiens	91-127
8346241-5	1993	Immunoprecipitation of [3H]myristic acid-radiolabeled human monocyte lysates with IgG antibodies to the 31-kDa IL-1 alpha precursor recovered a protein with the physicochemical properties of the IL-1 alpha N-terminal propiece (16 kDa, pI 4.45).	Myristic Acid	27-40	interleukin 1 alpha	Homo sapiens	111-121
8346241-5	1993	Immunoprecipitation of [3H]myristic acid-radiolabeled human monocyte lysates with IgG antibodies to the 31-kDa IL-1 alpha precursor recovered a protein with the physicochemical properties of the IL-1 alpha N-terminal propiece (16 kDa, pI 4.45).	Myristic Acid	27-40	interleukin 1 alpha	Homo sapiens	195-205
8346241-7	1993	To determine which lysine(s) are acylated, a series of synthetic peptides containing all lysines found in the IL-1 alpha N-terminal propiece were used in an in vitro myristoylation assay containing peptide, myristoyl-CoA, and monocyte lysate as enzyme source.	Lysine	89-96	interleukin 1 alpha	Homo sapiens	110-120
8372116-6	1993	Pretreatment with 1 mg/kg L364 partially blocked the decrease in food intake and gastric stasis induced by IL-1 alpha.	3-(4-chlorophenyl)pentanedioic acid	26-30	interleukin 1 alpha	Homo sapiens	107-117
8304239-0	1993	Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture.	Arachidonic Acid	60-76	interleukin 1 alpha	Homo sapiens	24-43
8304239-3	1993	Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1 alpha or beta: prostaglandin E2, F2 alpha and 6-keto-prostaglandin F1 alpha.	Prostaglandins	65-79	interleukin 1 alpha	Homo sapiens	102-121
8304239-3	1993	Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1 alpha or beta: prostaglandin E2, F2 alpha and 6-keto-prostaglandin F1 alpha.	Dinoprostone	131-147	interleukin 1 alpha	Homo sapiens	102-121
8304239-3	1993	Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1 alpha or beta: prostaglandin E2, F2 alpha and 6-keto-prostaglandin F1 alpha.	6-Ketoprostaglandin F1 alpha	162-191	interleukin 1 alpha	Homo sapiens	102-121
8304239-4	1993	Regarding the synthesis of these prostaglandins, IL-1 beta was again more potent than IL-1 alpha.	Prostaglandins	33-47	interleukin 1 alpha	Homo sapiens	86-96
8346241-0	1993	The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.	Lysine	73-80	interleukin 1 alpha	Homo sapiens	24-43
8346241-4	1993	We report that the N terminus of the 31-kDa IL-1 alpha precursor is myristoylated on specific internal lysine residues.	Lysine	103-109	interleukin 1 alpha	Homo sapiens	44-54
8346241-5	1993	Immunoprecipitation of [3H]myristic acid-radiolabeled human monocyte lysates with IgG antibodies to the 31-kDa IL-1 alpha precursor recovered a protein with the physicochemical properties of the IL-1 alpha N-terminal propiece (16 kDa, pI 4.45).	Tritium	24-26	interleukin 1 alpha	Homo sapiens	111-121
8317554-7	1993	Enzyme induction with paraquat, adriamycin, or bleomycin was inhibitable by neutralizing antibody to interleukin-1 and tumor necrosis factor, suggesting that the inductions observed with these three drugs are due to the distal mediators, interleukin-1 or tumor necrosis factor released from the cells.	Paraquat	22-30	interleukin 1 alpha	Homo sapiens	238-276
8317554-7	1993	Enzyme induction with paraquat, adriamycin, or bleomycin was inhibitable by neutralizing antibody to interleukin-1 and tumor necrosis factor, suggesting that the inductions observed with these three drugs are due to the distal mediators, interleukin-1 or tumor necrosis factor released from the cells.	Doxorubicin	32-42	interleukin 1 alpha	Homo sapiens	238-276
8317554-7	1993	Enzyme induction with paraquat, adriamycin, or bleomycin was inhibitable by neutralizing antibody to interleukin-1 and tumor necrosis factor, suggesting that the inductions observed with these three drugs are due to the distal mediators, interleukin-1 or tumor necrosis factor released from the cells.	Bleomycin	47-56	interleukin 1 alpha	Homo sapiens	238-276
8331300-0	1993	Modulation of comedonal levels of interleukin-1 in acne patients treated with tetracyclines.	Tetracyclines	78-91	interleukin 1 alpha	Homo sapiens	34-47
8225402-0	1993	Human recombinant interleukin-1 receptor antagonist (hrIL-1RA) inhibits prostaglandin E2 (PGE2) generation but not alkaline phosphatase activity in in vivo chronic granulomatous tissue induced by KMnO4.	Dinoprostone	72-88	interleukin 1 alpha	Homo sapiens	18-31
8225402-0	1993	Human recombinant interleukin-1 receptor antagonist (hrIL-1RA) inhibits prostaglandin E2 (PGE2) generation but not alkaline phosphatase activity in in vivo chronic granulomatous tissue induced by KMnO4.	Dinoprostone	90-94	interleukin 1 alpha	Homo sapiens	18-31
8225402-0	1993	Human recombinant interleukin-1 receptor antagonist (hrIL-1RA) inhibits prostaglandin E2 (PGE2) generation but not alkaline phosphatase activity in in vivo chronic granulomatous tissue induced by KMnO4.	Potassium Permanganate	196-201	interleukin 1 alpha	Homo sapiens	18-31
8225402-1	1993	Interleukin-1, a soluble polypeptide, plays an important role in inflammatory reactions by increasing prostaglandin E2 (PGE2) generation.	Dinoprostone	102-118	interleukin 1 alpha	Homo sapiens	0-13
8225402-1	1993	Interleukin-1, a soluble polypeptide, plays an important role in inflammatory reactions by increasing prostaglandin E2 (PGE2) generation.	Dinoprostone	120-124	interleukin 1 alpha	Homo sapiens	0-13
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	72-81	interleukin 1 alpha	Homo sapiens	0-10
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	72-81	interleukin 1 alpha	Homo sapiens	213-223
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Cimetidine	119-129	interleukin 1 alpha	Homo sapiens	0-10
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Cimetidine	119-129	interleukin 1 alpha	Homo sapiens	213-223
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	171-180	interleukin 1 alpha	Homo sapiens	0-10
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	171-180	interleukin 1 alpha	Homo sapiens	213-223
8325995-8	1993	Indomethacin, a cyclooxygenase inhibitor, significantly reduced IL-1 alpha-induced IL-1 beta synthesis, but had no effect on the histamine-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	64-74
8325995-9	1993	Histamine (10(-5) M) enhanced and sustained IL-1 beta mRNA levels in IL-1 alpha-stimulated PBMC.	Histamine	0-9	interleukin 1 alpha	Homo sapiens	69-79
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	9-18	interleukin 1 alpha	Homo sapiens	103-113
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	84-93	interleukin 1 alpha	Homo sapiens	103-113
8373725-0	1993	Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts.	Arachidonic Acid	60-76	interleukin 1 alpha	Homo sapiens	0-13
8373725-2	1993	Activation of arachidonic acid release by bradykinin was potentiated by interleukin-1 added either simultaneously with bradykinin or to cultures 24 h before addition of bradykinin.	Arachidonic Acid	14-30	interleukin 1 alpha	Homo sapiens	72-85
8373725-4	1993	The stimulation of arachidonic acid release in response to bradykinin, in the absence or presence of interleukin-1, was not affected by RHC-80267, an inhibitor of diacylglycerol kinase, suggesting that deacylation of diacylglycerol was not an important pathway of arachidonic acid production in cultures exposed to bradykinin.	Arachidonic Acid	19-35	interleukin 1 alpha	Homo sapiens	101-114
8373725-7	1993	On the other hand, interleukin-1 amplification of bradykinin-stimulated release of arachidonic acid was blocked by actinomycin D and cycloheximide.	Arachidonic Acid	83-99	interleukin 1 alpha	Homo sapiens	19-32
8373725-7	1993	On the other hand, interleukin-1 amplification of bradykinin-stimulated release of arachidonic acid was blocked by actinomycin D and cycloheximide.	Dactinomycin	115-128	interleukin 1 alpha	Homo sapiens	19-32
8373725-7	1993	On the other hand, interleukin-1 amplification of bradykinin-stimulated release of arachidonic acid was blocked by actinomycin D and cycloheximide.	Cycloheximide	133-146	interleukin 1 alpha	Homo sapiens	19-32
8331300-4	1993	All six minocycline-treated patients showed an increase in bioactive IL-1 alpha-like material compared with three of five tetracycline-treated patients.	Minocycline	8-19	interleukin 1 alpha	Homo sapiens	69-79
8378543-0	1993	The effects of interleukins 1 alpha and 1 beta on prostaglandin production by cultured human fetal membranes.	Prostaglandins	50-63	interleukin 1 alpha	Homo sapiens	15-46
7692435-1	1993	Using oligonucleotide-directed mutagenesis, the binding site on human interleukin-1 alpha (IL-1 alpha) for the human type I IL-1 receptor (IL-1R) has been analyzed.	Oligonucleotides	6-21	interleukin 1 alpha	Homo sapiens	70-89
7692435-1	1993	Using oligonucleotide-directed mutagenesis, the binding site on human interleukin-1 alpha (IL-1 alpha) for the human type I IL-1 receptor (IL-1R) has been analyzed.	Oligonucleotides	6-21	interleukin 1 alpha	Homo sapiens	91-101
8234146-0	1993	Effect of a benzylidene derivative, a novel antirheumatic agent, on IL-1 production.	benzylidene	12-23	interleukin 1 alpha	Homo sapiens	68-72
8234146-2	1993	PAL significantly inhibited interleukin-1 (IL-1) production and release in human monocytes in a dose dependent fashion under lipopolysaccharide (LPS) stimulation.	protocatechualdehyde	0-3	interleukin 1 alpha	Homo sapiens	28-41
8234146-2	1993	PAL significantly inhibited interleukin-1 (IL-1) production and release in human monocytes in a dose dependent fashion under lipopolysaccharide (LPS) stimulation.	protocatechualdehyde	0-3	interleukin 1 alpha	Homo sapiens	43-47
8234146-4	1993	To clarify the mechanism of action of ACP on rat adjuvant arthritis, we investigated the effects of PAL, a metabolite of ACP, on IL-1 production using synovial cell cultures derived from patients with rheumatoid arthritis.	protocatechualdehyde	100-103	interleukin 1 alpha	Homo sapiens	129-133
8234146-5	1993	PAL significantly inhibited the IL-1 beta production induced by IL-1 alpha or PMA without inhibition of total protein synthesis and cytotoxicity.	protocatechualdehyde	0-3	interleukin 1 alpha	Homo sapiens	64-74
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	103-113
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	181-191
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcium	4-11	interleukin 1 alpha	Homo sapiens	86-96
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcimycin	22-28	interleukin 1 alpha	Homo sapiens	86-96
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcimycin	30-36	interleukin 1 alpha	Homo sapiens	86-96
8395696-0	1993	Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells.	Arachidonic Acid	34-50	interleukin 1 alpha	Homo sapiens	11-30
8378543-3	1993	IL-1 alpha increased PGE2 levels on the fetal side of the membrane, indicating increased production of prostaglandin from the amnion, but had little effect on levels of PGE2 on the maternal side of the membrane.	Dinoprostone	21-25	interleukin 1 alpha	Homo sapiens	0-10
8395696-1	1993	The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2.	Arachidonic Acid	51-67	interleukin 1 alpha	Homo sapiens	36-46
8395696-5	1993	In the G292 cells, IL-1 alpha (50 U/ml) induced a 10-fold increase in PGE2 production at all the incubation times tested, and a significant two-fold increase in 5 hydroxyeicosatetraenoic acid (HETE) formation after 48 h. These effects were not seen in SaOS-2 cells under identical conditions.	Dinoprostone	70-74	interleukin 1 alpha	Homo sapiens	19-29
8395696-5	1993	In the G292 cells, IL-1 alpha (50 U/ml) induced a 10-fold increase in PGE2 production at all the incubation times tested, and a significant two-fold increase in 5 hydroxyeicosatetraenoic acid (HETE) formation after 48 h. These effects were not seen in SaOS-2 cells under identical conditions.	Hydroxyeicosatetraenoic Acids	163-191	interleukin 1 alpha	Homo sapiens	19-29
8378543-3	1993	IL-1 alpha increased PGE2 levels on the fetal side of the membrane, indicating increased production of prostaglandin from the amnion, but had little effect on levels of PGE2 on the maternal side of the membrane.	Prostaglandins	103-116	interleukin 1 alpha	Homo sapiens	0-10
8395696-5	1993	In the G292 cells, IL-1 alpha (50 U/ml) induced a 10-fold increase in PGE2 production at all the incubation times tested, and a significant two-fold increase in 5 hydroxyeicosatetraenoic acid (HETE) formation after 48 h. These effects were not seen in SaOS-2 cells under identical conditions.	Hydroxyeicosatetraenoic Acids	193-197	interleukin 1 alpha	Homo sapiens	19-29
8365458-1	1993	Recombinant human interleukin-1 alpha (rHu-IL-1 alpha) has been indicated to produce central antinociception in the mouse phenylquinone writhing test, the antinociception being unaffected by naloxone.	phenylbenzoquinone	122-135	interleukin 1 alpha	Homo sapiens	18-37
8118455-4	1993	Incubation of chondrocytes with diacerhein for 24 hours was not associated with substantial changes in glycosaminoglycan or collagen production but substantially antagonized interleukin-1-mediated enhancement of collagenase production.	diacerein	32-42	interleukin 1 alpha	Homo sapiens	174-187
8118455-8	1993	These data demonstrate that diacerhein can reduce or even abolish interleukin-1-mediated enhancement of collagenase production by joint chondrocytes.	diacerein	28-38	interleukin 1 alpha	Homo sapiens	66-79
8099911-2	1993	We have reported recently that colchicine and other microtubule-disrupting agents stimulated interleukin-1 (IL-1) alpha and beta synthesis in human monocytes.	Colchicine	31-41	interleukin 1 alpha	Homo sapiens	93-106
8099911-2	1993	We have reported recently that colchicine and other microtubule-disrupting agents stimulated interleukin-1 (IL-1) alpha and beta synthesis in human monocytes.	Colchicine	31-41	interleukin 1 alpha	Homo sapiens	108-119
8103313-0	1993	Experimental modulation of IL-1 production and cell surface molecule expression by levamisole.	Levamisole	83-93	interleukin 1 alpha	Homo sapiens	27-31
8103313-2	1993	Current results reveal that oral levamisole pre-treatment provides elicited peritoneal macrophages with the ability to respond better to ex vivo LPS stimulation, and that levamisole can directly act on LPS-stimulated macrophages in vitro, resulting in enhanced production of IL-1, a key mediator of the immune response.	Levamisole	33-43	interleukin 1 alpha	Homo sapiens	275-279
8103313-2	1993	Current results reveal that oral levamisole pre-treatment provides elicited peritoneal macrophages with the ability to respond better to ex vivo LPS stimulation, and that levamisole can directly act on LPS-stimulated macrophages in vitro, resulting in enhanced production of IL-1, a key mediator of the immune response.	Levamisole	171-181	interleukin 1 alpha	Homo sapiens	275-279
8103313-3	1993	These data offer further biological and immunologic evidence that IL-1 production is indeed enhanced by levamisole.	Levamisole	104-114	interleukin 1 alpha	Homo sapiens	66-70
8103313-5	1993	Increased IL-1 expression was found to occur for cells treated in vitro with levamisole, demonstrating that there were direct effects by levamisole on LPS-stimulated macrophage cytokine production.	Levamisole	77-87	interleukin 1 alpha	Homo sapiens	10-14
8103313-5	1993	Increased IL-1 expression was found to occur for cells treated in vitro with levamisole, demonstrating that there were direct effects by levamisole on LPS-stimulated macrophage cytokine production.	Levamisole	137-147	interleukin 1 alpha	Homo sapiens	10-14
8103313-10	1993	This in vivo result is consistent with in vitro data showing augmented IL-1 induction after levamisole treatment, since neopterin is a marker for macrophage activation and sIL-2R release correlates with IL-2 production and binding after IL-1 activation of T-cells.	Levamisole	92-102	interleukin 1 alpha	Homo sapiens	71-75
8103313-10	1993	This in vivo result is consistent with in vitro data showing augmented IL-1 induction after levamisole treatment, since neopterin is a marker for macrophage activation and sIL-2R release correlates with IL-2 production and binding after IL-1 activation of T-cells.	Levamisole	92-102	interleukin 1 alpha	Homo sapiens	237-241
8103313-10	1993	This in vivo result is consistent with in vitro data showing augmented IL-1 induction after levamisole treatment, since neopterin is a marker for macrophage activation and sIL-2R release correlates with IL-2 production and binding after IL-1 activation of T-cells.	Neopterin	120-129	interleukin 1 alpha	Homo sapiens	71-75
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-196	interleukin 1 alpha	Homo sapiens	18-31
8099911-5	1993	These results suggested that the colchicine-mediated IL-1 induction was generated by microtubule disassembly.	Colchicine	33-43	interleukin 1 alpha	Homo sapiens	53-57
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	interleukin 1 alpha	Homo sapiens	18-31
8099911-7	1993	The use of different protein kinase inhibitors supported a role of the PKA, but not the PKC, in the colchicine-induced IL-1 production.	Colchicine	100-110	interleukin 1 alpha	Homo sapiens	119-123
8099911-8	1993	Furthermore, elevation of intracellular cAMP levels by 8-bromo-cAMP, forskolin, or cholera toxin potentiated the effect of suboptimal concentration of colchicine on IL-1 synthesis.	Cyclic AMP	40-44	interleukin 1 alpha	Homo sapiens	165-169
8099911-8	1993	Furthermore, elevation of intracellular cAMP levels by 8-bromo-cAMP, forskolin, or cholera toxin potentiated the effect of suboptimal concentration of colchicine on IL-1 synthesis.	8-Bromo Cyclic Adenosine Monophosphate	55-67	interleukin 1 alpha	Homo sapiens	165-169
8370313-10	1993	After the 24-h incubation, PGE2 and IL-1 alpha released by frozen LSE (PGE2 = 1126 +/- 208 pg/0.1 ml; IL-1 alpha = 80.6 +/- 6.8 pg/0.1 ml) remained significantly higher than controls (PGE2 = 229.0 +/- 45 pg/0.1 ml; IL-1 alpha = 4.9 +/- 0.7 pg/0.1 ml).	Dinoprostone	27-31	interleukin 1 alpha	Homo sapiens	102-112
8099911-8	1993	Furthermore, elevation of intracellular cAMP levels by 8-bromo-cAMP, forskolin, or cholera toxin potentiated the effect of suboptimal concentration of colchicine on IL-1 synthesis.	Colforsin	69-78	interleukin 1 alpha	Homo sapiens	165-169
8099911-8	1993	Furthermore, elevation of intracellular cAMP levels by 8-bromo-cAMP, forskolin, or cholera toxin potentiated the effect of suboptimal concentration of colchicine on IL-1 synthesis.	Colchicine	151-161	interleukin 1 alpha	Homo sapiens	165-169
8370313-10	1993	After the 24-h incubation, PGE2 and IL-1 alpha released by frozen LSE (PGE2 = 1126 +/- 208 pg/0.1 ml; IL-1 alpha = 80.6 +/- 6.8 pg/0.1 ml) remained significantly higher than controls (PGE2 = 229.0 +/- 45 pg/0.1 ml; IL-1 alpha = 4.9 +/- 0.7 pg/0.1 ml).	Dinoprostone	27-31	interleukin 1 alpha	Homo sapiens	102-112
8370313-10	1993	After the 24-h incubation, PGE2 and IL-1 alpha released by frozen LSE (PGE2 = 1126 +/- 208 pg/0.1 ml; IL-1 alpha = 80.6 +/- 6.8 pg/0.1 ml) remained significantly higher than controls (PGE2 = 229.0 +/- 45 pg/0.1 ml; IL-1 alpha = 4.9 +/- 0.7 pg/0.1 ml).	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	36-46
8370313-10	1993	After the 24-h incubation, PGE2 and IL-1 alpha released by frozen LSE (PGE2 = 1126 +/- 208 pg/0.1 ml; IL-1 alpha = 80.6 +/- 6.8 pg/0.1 ml) remained significantly higher than controls (PGE2 = 229.0 +/- 45 pg/0.1 ml; IL-1 alpha = 4.9 +/- 0.7 pg/0.1 ml).	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	36-46
8397767-3	1993	For example, IL-1 induction of prostaglandins is one target in treating disease, and drugs preventing the production of inhibiting cyclooxygenase have well-known toxicities because they block the normal synthesis of prostaglandins in many tissues.	Prostaglandins	31-45	interleukin 1 alpha	Homo sapiens	13-17
8397767-3	1993	For example, IL-1 induction of prostaglandins is one target in treating disease, and drugs preventing the production of inhibiting cyclooxygenase have well-known toxicities because they block the normal synthesis of prostaglandins in many tissues.	Prostaglandins	216-230	interleukin 1 alpha	Homo sapiens	13-17
8397767-4	1993	IL-1 blockading agents, in contrast, affect only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of these molecules for homeostasis.	Prostaglandins	65-78	interleukin 1 alpha	Homo sapiens	0-4
8397767-4	1993	IL-1 blockading agents, in contrast, affect only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of these molecules for homeostasis.	Prostaglandins	65-78	interleukin 1 alpha	Homo sapiens	105-109
8514886-5	1993	Herbimycin A also decreased elevated blood calcium levels that were induced either by repeated subcutaneous injections of recombinant human interleukin-1 alpha or by a human tumor.	herbimycin	0-12	interleukin 1 alpha	Homo sapiens	140-159
8314823-6	1993	Exposure to titanium-aluminum-vanadium increased the release of prostaglandin E2, interleukin-1, tumor necrosis factor, and interleukin-6.	titanium-aluminum-vanadium	12-38	interleukin 1 alpha	Homo sapiens	64-118
8514886-5	1993	Herbimycin A also decreased elevated blood calcium levels that were induced either by repeated subcutaneous injections of recombinant human interleukin-1 alpha or by a human tumor.	Calcium	43-50	interleukin 1 alpha	Homo sapiens	140-159
8512591-1	1993	Interleukin-1 alpha (IL-1 alpha) exerts antiproliferative effects on a human ovarian carcinoma cell line, NIH:OVCAR-3, which is resistant to clinically relevant concentrations of doxorubicin (DOX) and other chemotherapeutic agents.	Doxorubicin	179-190	interleukin 1 alpha	Homo sapiens	21-31
8512591-1	1993	Interleukin-1 alpha (IL-1 alpha) exerts antiproliferative effects on a human ovarian carcinoma cell line, NIH:OVCAR-3, which is resistant to clinically relevant concentrations of doxorubicin (DOX) and other chemotherapeutic agents.	Doxorubicin	192-195	interleukin 1 alpha	Homo sapiens	0-19
8512591-1	1993	Interleukin-1 alpha (IL-1 alpha) exerts antiproliferative effects on a human ovarian carcinoma cell line, NIH:OVCAR-3, which is resistant to clinically relevant concentrations of doxorubicin (DOX) and other chemotherapeutic agents.	Doxorubicin	192-195	interleukin 1 alpha	Homo sapiens	21-31
8512591-6	1993	DOX was found to significantly increase IL-1 alpha accumulation by NIH:OVCAR-3 cells after long-term (48 hr) exposure to the cytokine at 37 degrees, which might be due to increased nonspecific fluid phase uptake or to interference with cytokine degradation and/or release processes.	Doxorubicin	0-3	interleukin 1 alpha	Homo sapiens	40-50
7684300-6	1993	Similar concentrations of forskolin, PGE1 and db cyclic AMP enhanced significantly constitutive thrombomodulin activity and reversed the decrease of this activity caused by interleukin-1 (IL-1).	Colforsin	26-35	interleukin 1 alpha	Homo sapiens	188-192
7684300-6	1993	Similar concentrations of forskolin, PGE1 and db cyclic AMP enhanced significantly constitutive thrombomodulin activity and reversed the decrease of this activity caused by interleukin-1 (IL-1).	Alprostadil	37-41	interleukin 1 alpha	Homo sapiens	188-192
7684300-6	1993	Similar concentrations of forskolin, PGE1 and db cyclic AMP enhanced significantly constitutive thrombomodulin activity and reversed the decrease of this activity caused by interleukin-1 (IL-1).	db cyclic amp	46-59	interleukin 1 alpha	Homo sapiens	188-192
7684300-10	1993	Forskolin (10(-4) M) decreased the IL-1-induced tissue factor mRNA and increased the thrombomodulin mRNA level.	Colforsin	0-9	interleukin 1 alpha	Homo sapiens	35-39
8218931-2	1993	IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts.	Dinoprostone	75-91	interleukin 1 alpha	Homo sapiens	0-10
8218931-2	1993	IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts.	Dinoprostone	93-97	interleukin 1 alpha	Homo sapiens	0-10
8218931-3	1993	The effect of IL-1 alpha, IL-1 beta and TNF-alpha on PGE2 formation was significantly potentiated by EGF in a dose-dependent manner.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	14-24
8511981-1	1993	We studied the effect of menatetrenone, a vitamin K2 homolog, on bone resorption stimulated by interleukin-1 alpha (IL-1 alpha), prostaglandin E2 (PGE2), parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	menatetrenone	25-38	interleukin 1 alpha	Homo sapiens	95-114
8484101-5	1993	By contrast, IL-1 production by LPS- or silica-stimulated monocytes was not affected by this antibody.	Silicon Dioxide	40-46	interleukin 1 alpha	Homo sapiens	13-17
8212310-3	1993	For example, IL-1 induction of prostaglandins is one target in treating disease, and drugs preventing the production of inhibiting cyclooxygenase have well-known toxicities because they block the normal synthesis of prostaglandins in many tissues.	Prostaglandins	31-45	interleukin 1 alpha	Homo sapiens	13-17
8212310-3	1993	For example, IL-1 induction of prostaglandins is one target in treating disease, and drugs preventing the production of inhibiting cyclooxygenase have well-known toxicities because they block the normal synthesis of prostaglandins in many tissues.	Prostaglandins	216-230	interleukin 1 alpha	Homo sapiens	13-17
8212310-4	1993	IL-1 blockading agents, in contrast, affect only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of these molecules for homeostasis.	Prostaglandins	65-78	interleukin 1 alpha	Homo sapiens	0-4
8212310-4	1993	IL-1 blockading agents, in contrast, affect only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of these molecules for homeostasis.	Prostaglandins	65-78	interleukin 1 alpha	Homo sapiens	105-109
8473346-9	1993	Stimulation of the cells with tumor necrosis factor, phorbol 12-myristate 13-acetate, lipopolysaccharide, or interleukin-1 increased mRNA levels for PHS II, and this change correlated well with increased prostacyclin biosynthesis.	Epoprostenol	204-216	interleukin 1 alpha	Homo sapiens	109-122
8468485-0	1993	Cytokines and dexamethasone modulation of IL-1 receptors on human neutrophils in vitro.	Dexamethasone	14-27	interleukin 1 alpha	Homo sapiens	42-46
8468485-6	1993	Further studies showed that dexamethasone and GM-CSF (or G-CSF) synergistically increased IL-1 binding after 8 h. This synergistic modulation was a cytokine dose- and time-dependent process, and was due to an increase in IL-1R numbers rather than a change in binding affinity.	Dexamethasone	28-41	interleukin 1 alpha	Homo sapiens	90-94
8468485-7	1993	In addition, human bone marrow neutrophils, cord blood neutrophils, and several human hematopoietic cell lines (HL-60, U-937, and AML-193) responded to dexamethasone and GM-CSF (or G-CSF) with a superadditive increase in IL-1 binding.	Dexamethasone	152-165	interleukin 1 alpha	Homo sapiens	221-225
8476047-0	1993	Prostaglandin E2 downregulates Kupffer cell production of IL-1 and IL-6 during hepatic regeneration.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	58-62
8476047-5	1993	This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P &lt; 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media.	Arginine	133-141	interleukin 1 alpha	Homo sapiens	53-57
8476047-8	1993	When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P &lt; 0.05).	Indomethacin	34-46	interleukin 1 alpha	Homo sapiens	161-165
8476047-8	1993	When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P &lt; 0.05).	Arginine	133-141	interleukin 1 alpha	Homo sapiens	161-165
8049410-1	1993	Sympathetic innervation of the lungs and Interleukin-1 (IL-1) production by alveolar macrophages at urethan--induced carcinogenesis have been studied.	Urethane	100-107	interleukin 1 alpha	Homo sapiens	41-54
8049410-1	1993	Sympathetic innervation of the lungs and Interleukin-1 (IL-1) production by alveolar macrophages at urethan--induced carcinogenesis have been studied.	Urethane	100-107	interleukin 1 alpha	Homo sapiens	56-60
7683959-0	1993	IL1 and TNF alpha induce cGMP formation in C6 astrocytoma cells via the nitridergic pathway.	Cyclic GMP	25-29	interleukin 1 alpha	Homo sapiens	0-3
8437596-0	1993	The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin.	Carboplatin	87-98	interleukin 1 alpha	Homo sapiens	30-49
8383677-2	1993	In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.	Okadaic Acid	58-70	interleukin 1 alpha	Homo sapiens	183-202
8383677-2	1993	In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.	calyculin A	75-86	interleukin 1 alpha	Homo sapiens	183-202
8383677-7	1993	The stimulation of interleukin-1 alpha production by okadaic acid was more modest than that of interleukin-1 beta.	Okadaic Acid	53-65	interleukin 1 alpha	Homo sapiens	19-38
8213348-6	1993	Cytokines IL-1 alpha and TNF were also able to stimulate PGI2 synthesis, although to a lesser extent.	Epoprostenol	57-61	interleukin 1 alpha	Homo sapiens	10-20
7683888-2	1993	Incorporation of labelled thymidine was significantly decreased by IL-6, IL-1 and HGF but only slightly by LIF and RA.	Thymidine	26-35	interleukin 1 alpha	Homo sapiens	73-77
8490954-6	1993	Treatment of muscles with cyclo-oxygenase inhibitors, indomethacin (1 x 10(-5) M) or acetyl salicylic acid (2 x 10(-4) M), abolished the prolongation of action potential duration elicited by IL-1.	Indomethacin	54-66	interleukin 1 alpha	Homo sapiens	191-195
8490954-6	1993	Treatment of muscles with cyclo-oxygenase inhibitors, indomethacin (1 x 10(-5) M) or acetyl salicylic acid (2 x 10(-4) M), abolished the prolongation of action potential duration elicited by IL-1.	Aspirin	85-106	interleukin 1 alpha	Homo sapiens	191-195
8490954-7	1993	However, the effects of IL-1 were also blocked by the lipoxygenase inhibitor nordihydroguaiaretic acid (2 x 10(-5) M) or by treating tissues with the leukotriene receptor blocker, ICI198615 (1 x 10(-8) M).	Masoprocol	77-102	interleukin 1 alpha	Homo sapiens	24-28
8490954-7	1993	However, the effects of IL-1 were also blocked by the lipoxygenase inhibitor nordihydroguaiaretic acid (2 x 10(-5) M) or by treating tissues with the leukotriene receptor blocker, ICI198615 (1 x 10(-8) M).	ICI 198615	180-189	interleukin 1 alpha	Homo sapiens	24-28
8508557-0	1993	Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro.	Steroids	18-26	interleukin 1 alpha	Homo sapiens	48-52
8508557-2	1993	We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA.	Steroids	38-46	interleukin 1 alpha	Homo sapiens	68-81
8508557-2	1993	We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA.	Steroids	38-46	interleukin 1 alpha	Homo sapiens	83-87
8508557-4	1993	In studies of cells from normal male donors, 17-beta-estradiol at pharmacological concentrations (&gt; or = 10(-6) M) enhanced IL-1 and IL-6 secretion as well as the production of cell-associated IL-1.	Estradiol	45-62	interleukin 1 alpha	Homo sapiens	127-131
8508557-4	1993	In studies of cells from normal male donors, 17-beta-estradiol at pharmacological concentrations (&gt; or = 10(-6) M) enhanced IL-1 and IL-6 secretion as well as the production of cell-associated IL-1.	Estradiol	45-62	interleukin 1 alpha	Homo sapiens	196-200
8508557-5	1993	Progesterone and testosterone at similar concentrations inhibited IL-1 secretion but had no significant effect on IL-6 secretion or on the production of cell-associated IL-1.	Progesterone	0-12	interleukin 1 alpha	Homo sapiens	66-70
8508557-5	1993	Progesterone and testosterone at similar concentrations inhibited IL-1 secretion but had no significant effect on IL-6 secretion or on the production of cell-associated IL-1.	Testosterone	17-29	interleukin 1 alpha	Homo sapiens	66-70
8508557-8	1993	It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo.	Estradiol	21-38	interleukin 1 alpha	Homo sapiens	51-55
8508557-8	1993	It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo.	Progesterone	114-126	interleukin 1 alpha	Homo sapiens	157-161
8508557-8	1993	It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo.	Testosterone	132-144	interleukin 1 alpha	Homo sapiens	157-161
8281894-5	1993	Steroids play a dose dependent inhibitory role perhaps via GIF (Glucocorticoid Increasing Factor) and cytokines (IL 1).	Steroids	0-8	interleukin 1 alpha	Homo sapiens	113-117
8156173-1	1993	Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied.	Polycyclic Aromatic Hydrocarbons	76-108	interleukin 1 alpha	Homo sapiens	119-129
8156173-1	1993	Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied.	Polycyclic Aromatic Hydrocarbons	110-114	interleukin 1 alpha	Homo sapiens	119-129
8156173-2	1993	Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells.	beta-Naphthoflavone	12-31	interleukin 1 alpha	Homo sapiens	90-100
8388949-6	1993	In addition, the following values were decreased after dexamethasone therapy in the early treatment group: number of neutrophils in tracheobronchial aspirate fluid (p &lt; 0.05), and concentrations of leukotriene B4 (p &lt; 0.01), interleukin-1 (p &lt; 0.01), elastase-alpha 1-proteinase inhibitor (p &lt; 0.01), and albumin (p &lt; 0.01).	Dexamethasone	55-68	interleukin 1 alpha	Homo sapiens	231-244
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	44-63
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	65-69
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Water	106-111	interleukin 1 alpha	Homo sapiens	181-185
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	44-63
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	65-69
8340257-1	1993	Chemical conjugation of a recombinant human interleukin-1 alpha (IL-1) with gelatin was conducted using a water-soluble carbodiimide in an attempt to augment the indirect effect of IL-1 on in vivo tumor cell growth in mice.	Carbodiimides	120-132	interleukin 1 alpha	Homo sapiens	181-185
8285140-5	1993	Gentisate (2,5-DHB) and homogentisate (a tyrosine metabolite) inhibited the lymphoproliferative action of IL-1.	Gentisates	0-9	interleukin 1 alpha	Homo sapiens	106-110
8285140-5	1993	Gentisate (2,5-DHB) and homogentisate (a tyrosine metabolite) inhibited the lymphoproliferative action of IL-1.	2,5-dhb	11-18	interleukin 1 alpha	Homo sapiens	106-110
8285140-5	1993	Gentisate (2,5-DHB) and homogentisate (a tyrosine metabolite) inhibited the lymphoproliferative action of IL-1.	Homogentisic Acid	24-37	interleukin 1 alpha	Homo sapiens	106-110
8285140-5	1993	Gentisate (2,5-DHB) and homogentisate (a tyrosine metabolite) inhibited the lymphoproliferative action of IL-1.	Tyrosine	41-49	interleukin 1 alpha	Homo sapiens	106-110
7682484-1	1993	Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1 alpha (IL-1 alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma cells to ECs, and is associated with decreased EC 13-hydroxyoctadecadienoic acid (13-HODE) synthesis in vitro.	13-hydroxy-9,11-octadecadienoic acid	299-329	interleukin 1 alpha	Homo sapiens	82-101
7682484-1	1993	Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1 alpha (IL-1 alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma cells to ECs, and is associated with decreased EC 13-hydroxyoctadecadienoic acid (13-HODE) synthesis in vitro.	13-hydroxy-9,11-octadecadienoic acid	299-329	interleukin 1 alpha	Homo sapiens	103-113
7682484-1	1993	Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1 alpha (IL-1 alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma cells to ECs, and is associated with decreased EC 13-hydroxyoctadecadienoic acid (13-HODE) synthesis in vitro.	13-hydroxy-9,11-octadecadienoic acid	331-338	interleukin 1 alpha	Homo sapiens	82-101
7682484-1	1993	Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1 alpha (IL-1 alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma cells to ECs, and is associated with decreased EC 13-hydroxyoctadecadienoic acid (13-HODE) synthesis in vitro.	13-hydroxy-9,11-octadecadienoic acid	331-338	interleukin 1 alpha	Homo sapiens	103-113
8511981-4	1993	Indomethacin (10(-6) M) completely inhibited bone resorption induced by IL-1 alpha and partially inhibited bone resorption induced by 1,25-(OH)2D3.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	72-82
8511981-6	1993	Menatetrenone (3 x 10(-6)-3 x 10(-5) M) inhibited the bone resorption induced by IL-1 alpha (2 U/ml), PGE2 (10(-7) M), PTH (3 x 10(-7) M), and 1,25-(OH)2D3 (3 x 10(-10) M) in a dose-dependent manner.	menatetrenone	0-13	interleukin 1 alpha	Homo sapiens	81-91
8511981-7	1993	Menatetrenone also inhibited the PGE2 production stimulated by IL-1 alpha.	menatetrenone	0-13	interleukin 1 alpha	Homo sapiens	63-73
8511981-7	1993	Menatetrenone also inhibited the PGE2 production stimulated by IL-1 alpha.	Dinoprostone	33-37	interleukin 1 alpha	Homo sapiens	63-73
8336306-0	1993	Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells.	Hydroxychloroquine	46-64	interleukin 1 alpha	Homo sapiens	80-99
8336306-0	1993	Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells.	Hydroxychloroquine	46-64	interleukin 1 alpha	Homo sapiens	101-111
8336306-3	1993	Hydroxychloroquine inhibited production of IL-1-alpha (monocytes) and IL-6 (T cells and monocytes).	Hydroxychloroquine	0-18	interleukin 1 alpha	Homo sapiens	43-53
8321913-0	1993	Augmentation of interleukin-1 induced prostacyclin production by endothelial cell growth factor: implications for chronic synovitis.	Epoprostenol	38-50	interleukin 1 alpha	Homo sapiens	16-29
8476047-9	1993	We conclude that during hepatic regeneration, KC IL-1 and IL-6 production is elevated and is controlled in an autoregulatory fashion by elevated KC PGE2 production.	Dinoprostone	148-152	interleukin 1 alpha	Homo sapiens	49-53
8453620-5	1993	IL-1 and IL-6 also antagonized estradiol (10(-9) M) stimulated growth.	Estradiol	31-40	interleukin 1 alpha	Homo sapiens	0-4
8453620-11	1993	IL-1-induced TGF-beta secretion was blocked by estradiol (10(-9) M).	Estradiol	47-56	interleukin 1 alpha	Homo sapiens	0-4
8453620-13	1993	These findings indicate that IL-1 and IL-6 act additively to inhibit growth in the absence or presence of estradiol and modulate the estrogen receptor and progesterone receptor content of these cells.	Estradiol	106-115	interleukin 1 alpha	Homo sapiens	29-33
8453624-0	1993	Protective effects of recombinant human interleukin-1 alpha in doxorubicin-treated normal and tumor-bearing mice.	Doxorubicin	63-74	interleukin 1 alpha	Homo sapiens	40-59
8453624-1	1993	Experiments were performed to determine whether treatment with recombinant human IL-1 alpha (rhuIL-1 alpha) would protect C3H mice from the toxic effects of the widely used chemotherapeutic agent, doxorubicin (DXR).	Doxorubicin	197-208	interleukin 1 alpha	Homo sapiens	81-91
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	12-o-tetradecanoyl 13-phorbol acetate	0-37	interleukin 1 alpha	Homo sapiens	162-181
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	162-181
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	183-193
8396219-7	1993	The cytokine, interleukin-1, was a potent secretagogue of irCRF and this was effect-additive with the increase observed with forskolin, but not with PMA.	Colforsin	125-134	interleukin 1 alpha	Homo sapiens	14-27
8457602-2	1993	Tumor necrosis factor (TNF) and interleukin-1 (IL-1) synergistically stimulate the production of prostaglandin E2 (PGE2) by amnion cells.	Dinoprostone	97-113	interleukin 1 alpha	Homo sapiens	32-51
8457602-2	1993	Tumor necrosis factor (TNF) and interleukin-1 (IL-1) synergistically stimulate the production of prostaglandin E2 (PGE2) by amnion cells.	Dinoprostone	115-119	interleukin 1 alpha	Homo sapiens	32-51
8437596-8	1993	In contrast, 5 of the 15 patients given one of the two higher doses of interleukin-1 alpha after carboplatin had minimal thrombocytopenia (nadir, 91,000 to 332,000 platelets per cubic millimeter).	Carboplatin	97-108	interleukin 1 alpha	Homo sapiens	71-90
8437596-9	1993	In the 10 patients given 0.3 microgram of interleukin-1 alpha per kilogram after carboplatin treatment, the platelet count recovered to 100,000 per cubic millimeter significantly earlier than in either the control group (P = 0.002) or the patients who received interleukin-1 alpha before carboplatin (P = 0.003), with the median times to recovery in the three groups being 16, 21, and 23 days, respectively.	Carboplatin	81-92	interleukin 1 alpha	Homo sapiens	42-61
8437596-9	1993	In the 10 patients given 0.3 microgram of interleukin-1 alpha per kilogram after carboplatin treatment, the platelet count recovered to 100,000 per cubic millimeter significantly earlier than in either the control group (P = 0.002) or the patients who received interleukin-1 alpha before carboplatin (P = 0.003), with the median times to recovery in the three groups being 16, 21, and 23 days, respectively.	Carboplatin	288-299	interleukin 1 alpha	Homo sapiens	42-61
8437596-11	1993	CONCLUSIONS: Interleukin-1 alpha can accelerate the recovery of platelets after high-dose carboplatin therapy and may be clinically useful in preventing or treating thrombocytopenia induced by chemotherapy.	Carboplatin	90-101	interleukin 1 alpha	Homo sapiens	13-32
8503951-4	1993	Interleukin-1 (IL-1) and, to a lesser extent, tumor necrosis factor alpha (TNF alpha) stimulated GM-CSF formation within 3 h; mRNA levels also increased particularly in the presence of the protein synthesis inhibitor, cycloheximide.	Cycloheximide	218-231	interleukin 1 alpha	Homo sapiens	15-19
8503951-5	1993	IL-1, TNF alpha and, in addition, interferon-gamma (IFN-gamma) raised the M-CSF levels within 6 h; cycloheximide potentiated the effects of IL-1 and TNF alpha on mRNA levels.	Cycloheximide	99-112	interleukin 1 alpha	Homo sapiens	0-4
8503951-5	1993	IL-1, TNF alpha and, in addition, interferon-gamma (IFN-gamma) raised the M-CSF levels within 6 h; cycloheximide potentiated the effects of IL-1 and TNF alpha on mRNA levels.	Cycloheximide	99-112	interleukin 1 alpha	Homo sapiens	140-144
8482109-8	1993	The IL-1 alpha-induced mRNA and protein production were inhibited by dexamethasone.	Dexamethasone	69-82	interleukin 1 alpha	Homo sapiens	4-14
8156173-2	1993	Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells.	benz(a)anthracene	36-53	interleukin 1 alpha	Homo sapiens	90-100
8461522-5	1993	These cytokines also inhibit contractility and nitric oxide release (a vasodilator), and IL-1 and TNF-alpha have been found to reduce adrenergic stimulation of myocardial contractility by reducing intracellular cyclic AMP levels and uncoupling adenylate cyclase from beta receptors.	Cyclic AMP	211-221	interleukin 1 alpha	Homo sapiens	89-93
7679691-9	1993	LCM-induced proliferation of ionomycin-activated CD56dim NK cells was inhibited 24% by anti-IL-1 heteroantisera and 57% by anti-TNF antisera; a combination of both antisera inhibited proliferation by 73%.	Lincomycin	0-3	interleukin 1 alpha	Homo sapiens	92-96
7679691-9	1993	LCM-induced proliferation of ionomycin-activated CD56dim NK cells was inhibited 24% by anti-IL-1 heteroantisera and 57% by anti-TNF antisera; a combination of both antisera inhibited proliferation by 73%.	Ionomycin	29-38	interleukin 1 alpha	Homo sapiens	92-96
8357988-3	1993	(2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.	Prostaglandins	46-60	interleukin 1 alpha	Homo sapiens	21-24
8357988-3	1993	(2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.	Prostaglandins	62-65	interleukin 1 alpha	Homo sapiens	21-24
8357988-3	1993	(2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.	Prostaglandins	62-64	interleukin 1 alpha	Homo sapiens	21-24
8357988-3	1993	(2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.	Misoprostol	180-191	interleukin 1 alpha	Homo sapiens	21-24
8357988-6	1993	It is suggested that these NSAIDs induce IL1 synthesis by diminishing PG levels.	Prostaglandins	70-72	interleukin 1 alpha	Homo sapiens	41-44
8386286-2	1993	In our basic studies, HHM phi increased dose dependently the release of superoxide (O2-) and interleukin-1 (IL-1) when stimulated by opsonized zymosan, up to 1000 micrograms/dish.	Zymosan	143-150	interleukin 1 alpha	Homo sapiens	93-112
8502198-2	1993	The bacterial polysaccharides stimulate gingival neutrophils and macrophages to interleukin-1 (IL-1) production.	Polysaccharides	14-29	interleukin 1 alpha	Homo sapiens	80-99
8492010-3	1993	2) IL-1 stimulated the production of MMPs, TIMP and PGE2.	Dinoprostone	52-56	interleukin 1 alpha	Homo sapiens	3-7
8352010-0	1993	[Promoting effect of panaxatriol ginsenoside on gene expression of human interleukin-1].	panaxatriol ginsenoside	21-44	interleukin 1 alpha	Homo sapiens	73-87
8352010-1	1993	Effect of panaxatriol ginsenoside (PG) on interleukin-1 (IL-1) gene expression was studied by using wheat germ extract (cell-free translation system) and IL-1 bioassay.	panaxatriol ginsenoside	10-33	interleukin 1 alpha	Homo sapiens	57-61
8352010-1	1993	Effect of panaxatriol ginsenoside (PG) on interleukin-1 (IL-1) gene expression was studied by using wheat germ extract (cell-free translation system) and IL-1 bioassay.	pg	35-37	interleukin 1 alpha	Homo sapiens	57-61
8352010-1	1993	Effect of panaxatriol ginsenoside (PG) on interleukin-1 (IL-1) gene expression was studied by using wheat germ extract (cell-free translation system) and IL-1 bioassay.	pg	35-37	interleukin 1 alpha	Homo sapiens	154-158
8432990-4	1993	Evidence is presented for down-regulation of the IL-1-induced LIF activity by an endogenous cyclo-oxygenase product(s); the glucocorticoid, dexamethasone, lowered the IL-1-induced LIF activity and mRNA expression.	Dexamethasone	140-153	interleukin 1 alpha	Homo sapiens	49-53
8432990-4	1993	Evidence is presented for down-regulation of the IL-1-induced LIF activity by an endogenous cyclo-oxygenase product(s); the glucocorticoid, dexamethasone, lowered the IL-1-induced LIF activity and mRNA expression.	Dexamethasone	140-153	interleukin 1 alpha	Homo sapiens	167-171
8383401-3	1993	Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).	Lidocaine	5-14	interleukin 1 alpha	Homo sapiens	109-128
8383401-3	1993	Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).	Bupivacaine	19-30	interleukin 1 alpha	Homo sapiens	109-128
8383401-5	1993	In short-term (24 h) cultures of mononuclear cells the addition of lidocaine or bupivacaine reduced, in a dose-dependent manner, the level of IL-1 detected after stimulation with lipopolysaccharide (LPS).	Lidocaine	67-76	interleukin 1 alpha	Homo sapiens	142-146
8383401-5	1993	In short-term (24 h) cultures of mononuclear cells the addition of lidocaine or bupivacaine reduced, in a dose-dependent manner, the level of IL-1 detected after stimulation with lipopolysaccharide (LPS).	Bupivacaine	80-91	interleukin 1 alpha	Homo sapiens	142-146
8383401-6	1993	In all three assays (chemiluminescence, LTB4 and IL-1 RIA) bupivacaine was found to be more potent than lidocaine.	Bupivacaine	59-70	interleukin 1 alpha	Homo sapiens	49-53
8427707-2	1993	We have previously shown that AM produce a specific interleukin-1 (IL-1) inhibitor of 20 to 25 kD that blocks biologic activities of IL-1 alpha and IL-1 beta such as prostaglandin E2 production by fibroblasts.	Dinoprostone	166-182	interleukin 1 alpha	Homo sapiens	52-65
8427707-2	1993	We have previously shown that AM produce a specific interleukin-1 (IL-1) inhibitor of 20 to 25 kD that blocks biologic activities of IL-1 alpha and IL-1 beta such as prostaglandin E2 production by fibroblasts.	Dinoprostone	166-182	interleukin 1 alpha	Homo sapiens	67-71
8461062-7	1993	Furthermore, hrIL-1ra inhibited VSMC growth in the presence of exogenous mitogenic doses of IL-1 alpha.	vsmc	32-36	interleukin 1 alpha	Homo sapiens	92-102
8425199-6	1993	IL-1 caused a time- and dose-dependent increase in 125I-labeled IFN-gamma binding that was maximal at 6 h, persisted for at least 24 h, and was blocked by both actinomycin D and cycloheximide.	Dactinomycin	160-173	interleukin 1 alpha	Homo sapiens	0-4
8425199-6	1993	IL-1 caused a time- and dose-dependent increase in 125I-labeled IFN-gamma binding that was maximal at 6 h, persisted for at least 24 h, and was blocked by both actinomycin D and cycloheximide.	Cycloheximide	178-191	interleukin 1 alpha	Homo sapiens	0-4
8425199-8	1993	IL-1 also produced a time- and dose-dependent increase in IFN-gamma receptor mRNA levels that was maximal at 3 h and persisted for at least 24 h. Actinomycin D, but not cycloheximide, completely blocked the IL-1-mediated increase in IFN-gamma receptor mRNA levels.	Dactinomycin	146-159	interleukin 1 alpha	Homo sapiens	0-4
8425199-8	1993	IL-1 also produced a time- and dose-dependent increase in IFN-gamma receptor mRNA levels that was maximal at 3 h and persisted for at least 24 h. Actinomycin D, but not cycloheximide, completely blocked the IL-1-mediated increase in IFN-gamma receptor mRNA levels.	Dactinomycin	146-159	interleukin 1 alpha	Homo sapiens	207-211
8425199-8	1993	IL-1 also produced a time- and dose-dependent increase in IFN-gamma receptor mRNA levels that was maximal at 3 h and persisted for at least 24 h. Actinomycin D, but not cycloheximide, completely blocked the IL-1-mediated increase in IFN-gamma receptor mRNA levels.	Cycloheximide	169-182	interleukin 1 alpha	Homo sapiens	0-4
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	69-84	interleukin 1 alpha	Homo sapiens	204-214
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	244-259	interleukin 1 alpha	Homo sapiens	204-214
8440336-1	1993	The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6.	Tetradecanoylphorbol Acetate	170-173	interleukin 1 alpha	Homo sapiens	196-209
8440336-1	1993	The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6.	Tetradecanoylphorbol Acetate	170-173	interleukin 1 alpha	Homo sapiens	211-215
8463123-7	1993	Furthermore, SDS-PAGE analyses of lysates of the B-cell lines that had been affinity cross-linked with 125I-IL-1 alpha revealed two bands corresponding to IL-1R structures of 60 and 110 kD.	Sodium Dodecyl Sulfate	13-16	interleukin 1 alpha	Homo sapiens	108-118
8440758-8	1993	The effect of naproxen sodium on the IL-1-stimulated release was to suppress, but not totally overcome, the increased release of proteoglycan and neutral metalloproteinase activity.	Naproxen	14-29	interleukin 1 alpha	Homo sapiens	37-41
8440758-9	1993	In summary, these in vitro studies of cartilage metabolism indicate that naproxen sodium has the potential to suppress catabolic activities in articular cartilage, including those that are motivated by IL-1.	Naproxen	73-88	interleukin 1 alpha	Homo sapiens	202-206
8429822-2	1993	Dexamethasone (DEX) decreased levels of IL-1 alpha and IL-1 beta mRNAs in a dose-related fashion.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	40-50
8429822-2	1993	Dexamethasone (DEX) decreased levels of IL-1 alpha and IL-1 beta mRNAs in a dose-related fashion.	Dexamethasone	15-18	interleukin 1 alpha	Homo sapiens	40-50
8429822-3	1993	The DEX-induced decrease in levels of IL-1 alpha and IL-1 beta mRNAs was abolished by the steroid receptor antagonist RU486.	Dexamethasone	4-7	interleukin 1 alpha	Homo sapiens	38-48
8429822-3	1993	The DEX-induced decrease in levels of IL-1 alpha and IL-1 beta mRNAs was abolished by the steroid receptor antagonist RU486.	Mifepristone	118-123	interleukin 1 alpha	Homo sapiens	38-48
8429822-4	1993	The levels of IL-1 alpha and IL-1 beta proteins within the cells and of IL-1 beta in the culture medium were decreased by DEX to comparable extents, so that DEX had no detectable effect on cytokine secretion.	Dexamethasone	122-125	interleukin 1 alpha	Homo sapiens	14-24
8475825-3	1993	In this paper, we studied the time course of PGE2-synthesis and interaction between IL-1 and PGE2.	Dinoprostone	45-49	interleukin 1 alpha	Homo sapiens	84-88
8475825-3	1993	In this paper, we studied the time course of PGE2-synthesis and interaction between IL-1 and PGE2.	Dinoprostone	93-97	interleukin 1 alpha	Homo sapiens	84-88
8475825-4	1993	PGE2 concentration was measured by radioimmunoassay in the culture media to which rabbit antihuman IL-1 polyclonal antibody was added after culture for 6 h, 1 day, 1, 2, 3, 4, 5 and 6 weeks.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	99-103
8475825-6	1993	The results show that the antihuman IL-1 polyclonal antibody suppressed PGE2-synthesis.	Dinoprostone	72-76	interleukin 1 alpha	Homo sapiens	36-40
8475825-7	1993	Thus, IL-1 induces PGE2 synthesis in human LEC culture.	Dinoprostone	19-23	interleukin 1 alpha	Homo sapiens	6-10
8131658-4	1993	The production of IL-1 was tested through human monocytes stimulated with zymosan and measured by ELISA method; the activity of IL-1 was measured by its effect on the proliferation of murine thymocytes.	Zymosan	74-81	interleukin 1 alpha	Homo sapiens	18-22
8131658-5	1993	The results showed that Tripterygium Wilfordii Hook, Tripterygil Hyhoglauci Tetrandrine significantly inhibited both of IL-1 production and IL-1 activity; while Aconiti Tuber, Ephedrae Herba, Atractyloidis Rhizoma, Atractyloidis Lanceae Rhizoma, Ledebouiellae Radix slightly inhibited IL-1 activity but not affecting IL-1 production.	hyhoglauci tetrandrine	65-87	interleukin 1 alpha	Homo sapiens	120-124
8381280-0	1993	Cyclic adenosine 3",5"-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.	Cyclic AMP	0-36	interleukin 1 alpha	Homo sapiens	60-73
8381280-1	1993	This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells.	Cyclic AMP	35-39	interleukin 1 alpha	Homo sapiens	59-72
8381280-1	1993	This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells.	Cyclic AMP	35-39	interleukin 1 alpha	Homo sapiens	74-78
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Bucladesine	0-14	interleukin 1 alpha	Homo sapiens	126-130
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Colforsin	16-25	interleukin 1 alpha	Homo sapiens	126-130
8131658-5	1993	The results showed that Tripterygium Wilfordii Hook, Tripterygil Hyhoglauci Tetrandrine significantly inhibited both of IL-1 production and IL-1 activity; while Aconiti Tuber, Ephedrae Herba, Atractyloidis Rhizoma, Atractyloidis Lanceae Rhizoma, Ledebouiellae Radix slightly inhibited IL-1 activity but not affecting IL-1 production.	hyhoglauci tetrandrine	65-87	interleukin 1 alpha	Homo sapiens	140-144
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Staurosporine	27-40	interleukin 1 alpha	Homo sapiens	126-130
8131658-5	1993	The results showed that Tripterygium Wilfordii Hook, Tripterygil Hyhoglauci Tetrandrine significantly inhibited both of IL-1 production and IL-1 activity; while Aconiti Tuber, Ephedrae Herba, Atractyloidis Rhizoma, Atractyloidis Lanceae Rhizoma, Ledebouiellae Radix slightly inhibited IL-1 activity but not affecting IL-1 production.	hyhoglauci tetrandrine	65-87	interleukin 1 alpha	Homo sapiens	140-144
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Tetradecanoylphorbol Acetate	45-76	interleukin 1 alpha	Homo sapiens	126-130
8381280-3	1993	IL-1 was found to elicit a dose-dependent rise in adenyl cyclase activity in isolated K562 membranes, as well as increasing cAMP concentrations in whole cells.	Cyclic AMP	124-128	interleukin 1 alpha	Homo sapiens	0-4
8131658-5	1993	The results showed that Tripterygium Wilfordii Hook, Tripterygil Hyhoglauci Tetrandrine significantly inhibited both of IL-1 production and IL-1 activity; while Aconiti Tuber, Ephedrae Herba, Atractyloidis Rhizoma, Atractyloidis Lanceae Rhizoma, Ledebouiellae Radix slightly inhibited IL-1 activity but not affecting IL-1 production.	hyhoglauci tetrandrine	65-87	interleukin 1 alpha	Homo sapiens	140-144
8381280-4	1993	cAMP concentrations were found to peak within 3 minutes of IL-1 stimulation.	Cyclic AMP	0-4	interleukin 1 alpha	Homo sapiens	59-63
8237602-1	1993	While lipopolysaccharide endotoxin is the most prominent inducer of the kinecascade (TNF alpha, IL-1, 4, 6, 8) that leads to shock and multiple organ failure, bacterial exotoxins and products of certain gram positive bacteria can induce the same end results.	kinecascade	72-83	interleukin 1 alpha	Homo sapiens	96-109
8380591-4	1993	Isoforms of 32P-labeled Hsp27 were dephosphorylated during cold-chases with excess phosphate in the absence but not in the presence of TNF/IL-1 or inhibitors of protein phosphatases suggesting that inactivation of protein phosphatase(s) plays a role in TNF/IL-1 signal transduction.	Phosphorus-32	12-15	interleukin 1 alpha	Homo sapiens	257-261
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	45-70	interleukin 1 alpha	Homo sapiens	0-10
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 alpha	Homo sapiens	0-10
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	80-83	interleukin 1 alpha	Homo sapiens	0-10
8512018-7	1993	After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 alpha	Homo sapiens	34-44
8456622-0	1993	Possible role of IL-1 in arthritis: effects of prostaglandins in the regulation of IL-1 synthesis and actions.	Prostaglandins	47-61	interleukin 1 alpha	Homo sapiens	83-87
8273563-2	1993	MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 microM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well as IL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive.	MK-886	0-5	interleukin 1 alpha	Homo sapiens	55-59
8273563-2	1993	MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 microM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well as IL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive.	tepoxalin	31-40	interleukin 1 alpha	Homo sapiens	55-59
8456629-9	1993	As expected, hydrocortisone demonstrated a marked decrease on IL-1 alpha and IL-1 beta, both in the presence and absence of LPS.	Hydrocortisone	13-27	interleukin 1 alpha	Homo sapiens	62-72
8215585-4	1993	All MC lines, including the MC-a and the melanoma lines, showed expression of MHC class I, IL-1, IL-2, ICAM-1 and the MAA, NKI-Beteb, during all passages tested.	mc-a	28-32	interleukin 1 alpha	Homo sapiens	91-95
8442836-0	1993	The induction of IL-1 by freeze-dried ethylene oxide-treated bone-patellar tendon-bone allograft wear particles: an in vitro study.	Ethylene Oxide	38-52	interleukin 1 alpha	Homo sapiens	17-21
8018446-5	1993	In vitro this factor inhibited IL-1 induced proliferative responses as well as PGE2 secretion by IL-1 induced fibroblasts.	Dinoprostone	79-83	interleukin 1 alpha	Homo sapiens	97-101
8180318-1	1993	The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented.	Cyclic AMP	81-85	interleukin 1 alpha	Homo sapiens	25-43
7803193-2	1993	Pretreatment with recombinant human interleukin-1 beta (IL-1) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration.	Doxorubicin	114-124	interleukin 1 alpha	Homo sapiens	56-60
7803193-2	1993	Pretreatment with recombinant human interleukin-1 beta (IL-1) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration.	Doxorubicin	126-129	interleukin 1 alpha	Homo sapiens	56-60
8018447-5	1993	In vitro IL-1 induced proliferative responses of mouse thymocytes, human T cells and fibroblasts and IL-1 stimulated PGE2 secretion from fibroblasts, were all inhibited by the M20 IL-1 Inhibitor.	Dinoprostone	117-121	interleukin 1 alpha	Homo sapiens	101-105
7803193-4	1993	Neutrophil and platelet counts after the administration of ADM (16 mg/kg) did not differ between the group with and that without IL-1 pretreatment, whereas lipid peroxide levels in the heart were reduced in the group pretreated with IL-1.	Lipid Peroxides	156-170	interleukin 1 alpha	Homo sapiens	233-237
7803193-5	1993	It appears that the chemoprotection mechanism of IL-1 lies in the prevention of cardiotoxicity due to ADM-induced free radicals.	Doxorubicin	102-105	interleukin 1 alpha	Homo sapiens	49-53
8018447-5	1993	In vitro IL-1 induced proliferative responses of mouse thymocytes, human T cells and fibroblasts and IL-1 stimulated PGE2 secretion from fibroblasts, were all inhibited by the M20 IL-1 Inhibitor.	Dinoprostone	117-121	interleukin 1 alpha	Homo sapiens	101-105
8018447-8	1993	Levels of corticosterone and fibrinogen were increased by injection of IL-1, and decreased by the IL-1 Inhibitor.	Corticosterone	10-24	interleukin 1 alpha	Homo sapiens	71-75
8018447-9	1993	IL-1 reduced zinc and iron plasma levels and elevated copper plasma levels.	Iron	22-26	interleukin 1 alpha	Homo sapiens	0-4
8018447-9	1993	IL-1 reduced zinc and iron plasma levels and elevated copper plasma levels.	Copper	54-60	interleukin 1 alpha	Homo sapiens	0-4
8402271-0	1993	Modification of prostaglandin E2 and collagen synthesis in keratoconus fibroblasts, associated with an increase of interleukin 1 alpha receptor number.	Dinoprostone	16-32	interleukin 1 alpha	Homo sapiens	115-134
8402271-9	1993	When the cells are stimulated with IL1, synthesis of PGE2 strongly increases and the amounts produced by keratoconus cells are always higher than those of the normal cornea cells.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	35-38
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	doxifluridine	214-238	interleukin 1 alpha	Homo sapiens	90-109
7506142-8	1993	The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively.	Amines	185-191	interleukin 1 alpha	Homo sapiens	81-94
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	doxifluridine	214-238	interleukin 1 alpha	Homo sapiens	111-121
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	doxifluridine	240-248	interleukin 1 alpha	Homo sapiens	90-109
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	doxifluridine	240-248	interleukin 1 alpha	Homo sapiens	111-121
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	Fluorouracil	258-272	interleukin 1 alpha	Homo sapiens	90-109
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	Fluorouracil	258-272	interleukin 1 alpha	Homo sapiens	111-121
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	Fluorouracil	274-280	interleukin 1 alpha	Homo sapiens	90-109
8339382-1	1993	The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics.	Fluorouracil	274-280	interleukin 1 alpha	Homo sapiens	111-121
7584017-3	1993	The cytokines tumor necrosis factor and interleukin-1 also promote de novo lipogenesis in the liver and may be responsible for impaired triglyceride removal in peripheral tissues; these effects together contribute to the hypertriglyceridemia often seen in septic states.	Triglycerides	136-148	interleukin 1 alpha	Homo sapiens	40-53
8405009-9	1993	Both IL-1 and TNF production were significantly lower in patients receiving fenoterol plus flunisolide than in patients on fenoterol alone.	Fenoterol	76-85	interleukin 1 alpha	Homo sapiens	5-9
8419122-7	1993	Inhibition of LH-stimulated testosterone production was observed also when Leydig cells were cultured in the presence of testicular macrophages for 24 h before maximal LH stimulation (8 ng/ml) for a further 24 h. Human recombinant interleukin-1 alpha and interleukin-1 beta (0.5-10 U/ml) did not significantly alter basal or LH-stimulated Leydig cell testosterone production at 24, 48, or 72 h of culture.	Luteinizing Hormone	14-16	interleukin 1 alpha	Homo sapiens	231-250
8405009-9	1993	Both IL-1 and TNF production were significantly lower in patients receiving fenoterol plus flunisolide than in patients on fenoterol alone.	flunisolide	91-102	interleukin 1 alpha	Homo sapiens	5-9
8380280-6	1993	After stimulation with LPS-S, the largest quantity of TNF-alpha and IL-1 alpha released was less than that obtained after stimulation with LPS-R at the same concentration, while the quantity of IL-6 released was found to be slightly higher than that obtained after stimulation with porins or LPS-R. LPS-S (1 microgram/ml) induces IFN-gamma release from lymphocytes in notably smaller quantities than that obtained with LPS-R and slightly larger quantities than that obtained with porins.	Sulfur	25-26	interleukin 1 alpha	Homo sapiens	68-78
8217219-5	1993	The presence of the cyclooxygenase inhibitor, indomethacin, potentiated the action of IL-1 on M-CSF synthesis, suggesting that an endogenous cyclooxygenase product(s) can down-regulate M-CSF formation.	Indomethacin	46-58	interleukin 1 alpha	Homo sapiens	86-90
8508050-7	1993	Thymulin (1 ng/ml) resulted in a significant (p &lt; 0.01) increase in IL-1 alpha in the volunteers and a significant (p &lt; 0.05) inhibition of this cytokine at all dose levels tested in SLE patients, whose basal levels of IL-1 alpha were significantly (p &lt; 0.05) higher.	Thymic Factor, Circulating	0-8	interleukin 1 alpha	Homo sapiens	71-81
8508050-7	1993	Thymulin (1 ng/ml) resulted in a significant (p &lt; 0.01) increase in IL-1 alpha in the volunteers and a significant (p &lt; 0.05) inhibition of this cytokine at all dose levels tested in SLE patients, whose basal levels of IL-1 alpha were significantly (p &lt; 0.05) higher.	Thymic Factor, Circulating	0-8	interleukin 1 alpha	Homo sapiens	225-235
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	51-64
8144314-1	1993	Cyclic AMP, protein kinase A and NF kappa B have been implicated as second messengers in the interleukin-1 (IL-1) action pathway.	Cyclic AMP	0-10	interleukin 1 alpha	Homo sapiens	93-106
8144314-1	1993	Cyclic AMP, protein kinase A and NF kappa B have been implicated as second messengers in the interleukin-1 (IL-1) action pathway.	Cyclic AMP	0-10	interleukin 1 alpha	Homo sapiens	108-112
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	66-70
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Polylysine	175-185	interleukin 1 alpha	Homo sapiens	66-70
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 alpha	Homo sapiens	50-60
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Polylysine	143-153	interleukin 1 alpha	Homo sapiens	50-60
8341137-0	1993	The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.	Phenytoin	4-13	interleukin 1 alpha	Homo sapiens	115-128
8392131-2	1993	Surface protein expression of vascular cell adhesion molecule-1, endothelial leukocyte adhesion molecule-1, or intercellular adhesion molecule-1, which is induced by tumor necrosis factor, interleukin-1, and lipopolysaccharide, was not induced by pentoxyfilline, a phosphodiesterase inhibitor, nor by dibutyryl cyclic adenosine monophosphate.	Pentoxifylline	247-261	interleukin 1 alpha	Homo sapiens	189-202
8392131-2	1993	Surface protein expression of vascular cell adhesion molecule-1, endothelial leukocyte adhesion molecule-1, or intercellular adhesion molecule-1, which is induced by tumor necrosis factor, interleukin-1, and lipopolysaccharide, was not induced by pentoxyfilline, a phosphodiesterase inhibitor, nor by dibutyryl cyclic adenosine monophosphate.	Bucladesine	301-341	interleukin 1 alpha	Homo sapiens	189-202
8393508-0	1993	Failure of interleukin-1 to induce intracellular calcium fluxes in K562 cells.	Calcium	49-56	interleukin 1 alpha	Homo sapiens	11-24
8393508-1	1993	The ability of interleukin-1 to induce calcium fluxes in K562 cells, was examined using flow cytometry and the calcium chelator Indo-1.	Calcium	39-46	interleukin 1 alpha	Homo sapiens	15-28
8393508-1	1993	The ability of interleukin-1 to induce calcium fluxes in K562 cells, was examined using flow cytometry and the calcium chelator Indo-1.	Calcium	111-118	interleukin 1 alpha	Homo sapiens	15-28
8342574-5	1993	In vitro IL-1 production by LN PBM treated with lipopolysaccharide (LPS) was enhanced by coculture with GM-CSF.	pbm	31-34	interleukin 1 alpha	Homo sapiens	9-13
8380188-6	1993	Furthermore, HSV-precultured monocytes had a reduced production of IL-1 alpha and TNF-beta after phorbol-ionomycin stimulation.	phorbol	97-104	interleukin 1 alpha	Homo sapiens	67-77
8380188-6	1993	Furthermore, HSV-precultured monocytes had a reduced production of IL-1 alpha and TNF-beta after phorbol-ionomycin stimulation.	Ionomycin	105-114	interleukin 1 alpha	Homo sapiens	67-77
8341137-0	1993	The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.	p-hpph	25-31	interleukin 1 alpha	Homo sapiens	115-128
8341137-0	1993	The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.	Prostaglandins	44-57	interleukin 1 alpha	Homo sapiens	115-128
18475506-9	1993	It is concluded that cercarial penetration causes a release of IL-1alpha consistent with skin trauma; however, schistosomulae may regulate the production of chemotactic (neutrophils, macrophages, T-cells, etc.)	cercarial	21-30	interleukin 1 alpha	Homo sapiens	63-72
8341137-2	1993	IL-1 alpha, IL-1 beta and TNF alpha, dose-dependently, stimulated PGE2 formation in gingival fibroblasts.	Dinoprostone	66-70	interleukin 1 alpha	Homo sapiens	0-10
8341137-3	1993	The metabolite, p-HPPH (1.2-2.4 micrograms/ml), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH.	p-hpph	16-22	interleukin 1 alpha	Homo sapiens	101-111
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Calcitriol	0-10	interleukin 1 alpha	Homo sapiens	113-117
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	60-85	interleukin 1 alpha	Homo sapiens	113-117
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	87-90	interleukin 1 alpha	Homo sapiens	113-117
8461541-15	1993	PGE2 production and PGH synthase mRNA are increased by PTH and interleukin-1 and decreased by estrogen.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	63-76
8489769-0	1993	Effects of retinoic acid on interleukin-1 alpha and -1 beta expression by normal human keratinocytes cultured in defined medium.	Tretinoin	11-24	interleukin 1 alpha	Homo sapiens	28-59
8489769-2	1993	We investigated the effects of retinoic acid (RA) treatments on IL-1 alpha and -beta protein and mRNA expression of normal human keratinocytes cultured in low-calcium defined medium with or without hydrocortisone.	Tretinoin	46-48	interleukin 1 alpha	Homo sapiens	64-84
8489769-5	1993	Release of both IL-1 alpha and -beta in culture supernatants was detectable only after RA treatment and in the absence of hydrocortisone.	Tretinoin	87-89	interleukin 1 alpha	Homo sapiens	16-26
1469696-0	1992	A novel orally active inhibitor of IL-1 generation: synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives.	3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid	102-147	interleukin 1 alpha	Homo sapiens	35-39
18475522-0	1993	Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.	Benzylisoquinolines	22-44	interleukin 1 alpha	Homo sapiens	88-134
1283556-0	1992	Substance P stimulates IL-1 production by astrocytes via intracellular calcium.	Calcium	71-78	interleukin 1 alpha	Homo sapiens	23-27
1283556-5	1992	We found that both SP and the calcium ionophore A23187 raised intracellular calcium ([Ca2+]i) and stimulated IL-1 production in astrocytes.	Calcium	30-37	interleukin 1 alpha	Homo sapiens	109-113
1283556-5	1992	We found that both SP and the calcium ionophore A23187 raised intracellular calcium ([Ca2+]i) and stimulated IL-1 production in astrocytes.	Calcimycin	48-54	interleukin 1 alpha	Homo sapiens	109-113
1283556-7	1992	Treatment with dibromo BAPTA/AM, an intracellular calcium buffer, blocked SP-induced IL-1 production.	5,5'-dibromo-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	15-28	interleukin 1 alpha	Homo sapiens	85-89
1283556-7	1992	Treatment with dibromo BAPTA/AM, an intracellular calcium buffer, blocked SP-induced IL-1 production.	Calcium	50-57	interleukin 1 alpha	Homo sapiens	85-89
1469696-1	1992	A new series of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acids was prepared and the inhibitory activities of its members on IL-1 generation were evaluated both by in vitro systems using human monocytes and/or rat exudated macrophages stimulated with LPS, and by an in vivo system using the rat CMC-LPS air-pouch model.	3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid	16-62	interleukin 1 alpha	Homo sapiens	124-128
1469696-4	1992	Among the compounds evaluated, (Z)-3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propeno ic acid (20a), which inhibited IL-1 generation from human monocytes with an IC50 value of 3.0 microM and had an IC50 value of 1.4 microM for rat exudated macrophages, showed the most potent inhibitory activity in the rat CMC-LPS model by oral administration.	(z)-3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propeno ic acid	31-108	interleukin 1 alpha	Homo sapiens	132-136
1447187-0	1992	Interleukin-1 alpha mediates an alternative pathway for the antiproliferative action of poly(I.C) on human endothelial cells.	Poly I-C	88-97	interleukin 1 alpha	Homo sapiens	0-19
1447187-4	1992	In addition, the mRNA levels for the cytokines interleukin-1 alpha (IL-1 alpha) and interferon-beta 1 are induced in poly(I.C)-treated cells.	Poly I-C	117-126	interleukin 1 alpha	Homo sapiens	47-66
1447187-4	1992	In addition, the mRNA levels for the cytokines interleukin-1 alpha (IL-1 alpha) and interferon-beta 1 are induced in poly(I.C)-treated cells.	Poly I-C	117-126	interleukin 1 alpha	Homo sapiens	68-78
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Poly I-C	43-52	interleukin 1 alpha	Homo sapiens	109-119
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Poly I-C	43-52	interleukin 1 alpha	Homo sapiens	159-169
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Oligonucleotides	130-145	interleukin 1 alpha	Homo sapiens	109-119
1447187-5	1992	Moreover, the growth inhibitory effects of poly(I.C) are relieved when cells are grown in the presence of an IL-1 alpha antisense oligonucleotide to the human IL-1 alpha transcript.	Oligonucleotides	130-145	interleukin 1 alpha	Homo sapiens	159-169
1447187-6	1992	Thus, the effects of poly(I.C) appear to be mediated, in part, through the function of IL-1 alpha, suggesting an alternative pathway for dsRNA-mediated inhibition of human endothelial cell growth.	Poly I-C	21-30	interleukin 1 alpha	Homo sapiens	87-97
1472130-6	1992	Using cyclooxygenase inhibitors, evidence was obtained that an endogenous cyclooxygenase product(s) in the IL-1-treated cultures inhibited formation of both PAIs; exogenous prostaglandin E2 (10(-7) M) reversed the effect of cyclooxygenase inhibition.	Dinoprostone	173-189	interleukin 1 alpha	Homo sapiens	107-111
1476308-7	1992	Explants obtained from older horses were significantly (P &lt; 0.05) less responsive to interleukin 1, with respect to synthesis and release of glycosaminoglycan.	Glycosaminoglycans	144-161	interleukin 1 alpha	Homo sapiens	88-101
1472130-7	1992	The glucocorticoid dexamethasone (10(-6) to 10(-7) M) inhibited IL-1-stimulated PAI-2 formation but reversed the suppressive effect of IL-1 on PAI-1 production.	Dexamethasone	19-32	interleukin 1 alpha	Homo sapiens	64-68
1472130-7	1992	The glucocorticoid dexamethasone (10(-6) to 10(-7) M) inhibited IL-1-stimulated PAI-2 formation but reversed the suppressive effect of IL-1 on PAI-1 production.	Dexamethasone	19-32	interleukin 1 alpha	Homo sapiens	135-139
1482145-4	1992	Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice.	Corticosterone	10-24	interleukin 1 alpha	Homo sapiens	62-66
1476918-1	1992	Interleukin 1 (IL-1) immunoreactivity in sebaceous glands was studied in paraffin sections of normal human skin.	Paraffin	73-81	interleukin 1 alpha	Homo sapiens	0-19
1337276-10	1992	The stimulation of estradiol secretion and the inhibition of cell proliferation induced by IFN-alpha in cultured porcine granulosa cells in this study are in contrast with the effects of IL-1, which, as we reported previously, inhibited both progesterone and estradiol secretion and stimulated cell growth in these cell cultures.	Progesterone	242-254	interleukin 1 alpha	Homo sapiens	187-191
1487305-0	1992	Increased production of interleukin-1 and tumor necrosis factor by human monocytes treated in vitro with cisplatin or other biological response modifiers.	Cisplatin	105-114	interleukin 1 alpha	Homo sapiens	24-63
1493919-3	1992	injections of recombinant human IL-1 alpha and recombinant rabbit IL-1 alpha induced intense accumulation of 111In-labelled neutrophils which was dependent on the dose of the cytokines administered.	Indium-111	109-114	interleukin 1 alpha	Homo sapiens	32-42
1333514-0	1992	Interleukin 1-stimulated prostacyclin synthesis in endothelium: lack of phospholipase C, phospholipase D, or protein kinase C involvement in early signal transduction.	Epoprostenol	25-37	interleukin 1 alpha	Homo sapiens	0-13
1281830-3	1992	Human endothelial cells (ECs) subjected to hypoxia (PO2 approximately 12-14 Torr) elaborated IL-1 activity into conditioned media in a time-dependent manner; this activity was completely neutralized by an antibody to IL-1 alpha.	PO-2	52-55	interleukin 1 alpha	Homo sapiens	217-227
1333514-11	1992	Despite the absence of increased plasma membrane protein kinase C activity up to 4 hours after interleukin 1, pretreatment of human umbilical vein endothelium monolayers with staurosporine or phorbol myristate acetate (18 hours) to reduce protein kinase C activities, significantly attenuated the interleukin 1-stimulated prostanoid responses at 16 hours but not at 4 hours.	Tetradecanoylphorbol Acetate	192-217	interleukin 1 alpha	Homo sapiens	297-310
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	34-39	interleukin 1 alpha	Homo sapiens	116-129
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Tetradecanoylphorbol Acetate	48-73	interleukin 1 alpha	Homo sapiens	97-110
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Tetradecanoylphorbol Acetate	48-73	interleukin 1 alpha	Homo sapiens	213-226
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Egtazic Acid	76-80	interleukin 1 alpha	Homo sapiens	116-129
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Epoprostenol	120-132	interleukin 1 alpha	Homo sapiens	97-110
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Epoprostenol	120-132	interleukin 1 alpha	Homo sapiens	213-226
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Epoprostenol	146-158	interleukin 1 alpha	Homo sapiens	116-129
1333514-11	1992	Despite the absence of increased plasma membrane protein kinase C activity up to 4 hours after interleukin 1, pretreatment of human umbilical vein endothelium monolayers with staurosporine or phorbol myristate acetate (18 hours) to reduce protein kinase C activities, significantly attenuated the interleukin 1-stimulated prostanoid responses at 16 hours but not at 4 hours.	Staurosporine	175-188	interleukin 1 alpha	Homo sapiens	297-310
1494711-4	1992	Supplementing the diet with essential fatty acids (omega-3 and/or omega-6) may inhibit the production of some of the mediators of inflammation, such as leukotriene-B4 and interleukin-1.	Fatty Acids, Essential	28-49	interleukin 1 alpha	Homo sapiens	171-184
1479286-11	1992	However, anti-TNF antibodies and interleukin 1 receptor antagonist (IL-1ra) blocked the increase in serum triglycerides induced by TNF or IL-1, respectively.	Triglycerides	106-119	interleukin 1 alpha	Homo sapiens	68-72
1494711-4	1992	Supplementing the diet with essential fatty acids (omega-3 and/or omega-6) may inhibit the production of some of the mediators of inflammation, such as leukotriene-B4 and interleukin-1.	omega-3	51-58	interleukin 1 alpha	Homo sapiens	171-184
1339739-2	1992	The results showed that IL-1 activity of the monocyte culture supernatant was decreased in the preoperative patients, compared with that of controls or postoperative groups; the PGE2 content of the culture supernatant of monocytes from the preoperative cases was increased, compared to normal controls or to the postoperative groups.	Dinoprostone	178-182	interleukin 1 alpha	Homo sapiens	24-28
1465772-3	1992	Irradiated or mitomycin-c treated PBMC could easily be induced (with LPS) to produce IL-6 and IL-1 while no activity was measured after 48 hr in the supernatant of PHA-stimulated T cells, suggesting that in the MLC the monokines were entirely produced by stimulator PBMC.	Mitomycin	14-25	interleukin 1 alpha	Homo sapiens	94-98
1494711-4	1992	Supplementing the diet with essential fatty acids (omega-3 and/or omega-6) may inhibit the production of some of the mediators of inflammation, such as leukotriene-B4 and interleukin-1.	omega-6	66-73	interleukin 1 alpha	Homo sapiens	171-184
1429687-0	1992	Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.	Dinoprostone	94-110	interleukin 1 alpha	Homo sapiens	0-19
1339739-3	1992	Again, we found that there was significant negative correlation between IL-1 activity and the PGE2 content, with the activity of IL-1 the lowest and the content of PGE2 the highest in advanced colonic cancer patients.	Dinoprostone	94-98	interleukin 1 alpha	Homo sapiens	72-76
1339739-3	1992	Again, we found that there was significant negative correlation between IL-1 activity and the PGE2 content, with the activity of IL-1 the lowest and the content of PGE2 the highest in advanced colonic cancer patients.	Dinoprostone	94-98	interleukin 1 alpha	Homo sapiens	129-133
1339739-3	1992	Again, we found that there was significant negative correlation between IL-1 activity and the PGE2 content, with the activity of IL-1 the lowest and the content of PGE2 the highest in advanced colonic cancer patients.	Dinoprostone	164-168	interleukin 1 alpha	Homo sapiens	72-76
1429687-1	1992	Treatment of the human lung fibroblast cell line, WI-38, with interleukin-1 alpha (IL-1 alpha) results in a large increase in the production of cytosolic phospholipase A2 (cPLA2) and prostaglandin E2 (PGE2).	Dinoprostone	183-199	interleukin 1 alpha	Homo sapiens	62-81
1429687-4	1992	The glucocorticoid, dexamethasone, blocks the IL-1 alpha-mediated increases in both cPLA2 and PGE2 without affecting the cyclooxygenase level.	Dinoprostone	94-98	interleukin 1 alpha	Homo sapiens	46-56
1429687-1	1992	Treatment of the human lung fibroblast cell line, WI-38, with interleukin-1 alpha (IL-1 alpha) results in a large increase in the production of cytosolic phospholipase A2 (cPLA2) and prostaglandin E2 (PGE2).	Dinoprostone	183-199	interleukin 1 alpha	Homo sapiens	83-93
1429687-5	1992	Taken together, these data suggest that in these cells, the regulation of prostaglandin production by IL-1 and glucocorticoid can be attributed to the level of cPLA2.	Prostaglandins	74-87	interleukin 1 alpha	Homo sapiens	102-106
1429687-1	1992	Treatment of the human lung fibroblast cell line, WI-38, with interleukin-1 alpha (IL-1 alpha) results in a large increase in the production of cytosolic phospholipase A2 (cPLA2) and prostaglandin E2 (PGE2).	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	62-81
1429687-6	1992	These results provide a new mechanism for the effect of IL-1 and glucocorticoids on eicosanoid synthesis and provide additional support for an important role of cPLA2 in the inflammatory response.	Eicosanoids	84-94	interleukin 1 alpha	Homo sapiens	56-60
1429687-1	1992	Treatment of the human lung fibroblast cell line, WI-38, with interleukin-1 alpha (IL-1 alpha) results in a large increase in the production of cytosolic phospholipase A2 (cPLA2) and prostaglandin E2 (PGE2).	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	83-93
1429687-2	1992	The IL-1-induced accumulation of cPLA2 is closely correlated with increased PGE2 release.	Dinoprostone	76-80	interleukin 1 alpha	Homo sapiens	4-8
1429687-4	1992	The glucocorticoid, dexamethasone, blocks the IL-1 alpha-mediated increases in both cPLA2 and PGE2 without affecting the cyclooxygenase level.	Dexamethasone	20-33	interleukin 1 alpha	Homo sapiens	46-56
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 alpha	Homo sapiens	68-87
1424289-2	1992	In this study we have examined the effects of the corticosteroid prednisolone on the production of IL-1 alpha and IL-1 beta by lipopolysaccharide (LPS)-stimulated monocytes, and the ability of the monocyte conditioned media (MOCM) obtained under these conditions to induce human hepatoma HepG2 cells to produce serum amyloid A (SAA) and C-reactive protein (CRP).	Prednisolone	65-77	interleukin 1 alpha	Homo sapiens	99-109
1424289-4	1992	The findings indicate: (i) prednisolone substantially inhibits the production of both IL-1 alpha and IL-1 beta by LPS-stimulated monocytes.	Prednisolone	27-39	interleukin 1 alpha	Homo sapiens	86-96
1421374-4	1992	Recently, interleukin-1 (IL-1) production has been found to be decreased in lipopolysaccharide-stimulated peripheral blood monocytes obtained from SAA patients.	saa	147-150	interleukin 1 alpha	Homo sapiens	10-29
1292637-0	1992	IL-1 synergizes with ARA-C in aborting the development of chloroleukemia while protecting from ARA-C-induced alopecia in the rat model.	Cytarabine	95-100	interleukin 1 alpha	Homo sapiens	0-4
1424289-5	1992	The MOCM from prednisolone-treated monocytes induced less SAA and CRP production by HepG2 cells; (ii) IL-1 alpha and IL-1 beta both induced CRP and SAA synthesis by HepG2 cells, but only in the presence of IL-6.	Prednisolone	14-26	interleukin 1 alpha	Homo sapiens	102-112
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 alpha	Homo sapiens	89-99
1292637-1	1992	Recently, interleukin 1 (IL-1) was shown to protect rats from ARA-C-induced alopecia.	Cytarabine	62-67	interleukin 1 alpha	Homo sapiens	25-29
1337984-8	1992	At these concentrations, both compounds effectively inhibited IL-1-driven PGE2 and IL-6 induction without affecting general protein synthesis or secretion.	Dinoprostone	74-78	interleukin 1 alpha	Homo sapiens	62-66
1292637-2	1992	The present study was designed to investigate the effect of combination rHu-IL-1 and ARA-C on transplantable chloroleukemia (C51) and at the same time evaluate the protective effect of IL-1 on the ARA-C-induced alopecia in the rat model.	Cytarabine	197-202	interleukin 1 alpha	Homo sapiens	185-189
1292637-7	1992	Thus, IL-1 demonstrated a double beneficial effect, synergism with ARA-C against the leukemic cells on the one hand, and protection from ARA-C-induced alopecia, on the other.	Cytarabine	67-72	interleukin 1 alpha	Homo sapiens	6-10
1292637-7	1992	Thus, IL-1 demonstrated a double beneficial effect, synergism with ARA-C against the leukemic cells on the one hand, and protection from ARA-C-induced alopecia, on the other.	Cytarabine	137-142	interleukin 1 alpha	Homo sapiens	6-10
1291559-0	1992	Interactions between interferon gamma, tumour necrosis factor alpha, and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture.	Progesterone	101-113	interleukin 1 alpha	Homo sapiens	73-86
1291559-0	1992	Interactions between interferon gamma, tumour necrosis factor alpha, and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture.	Estradiol	118-128	interleukin 1 alpha	Homo sapiens	73-86
1291559-6	1992	In addition, IL-1 and TNF alpha, neither of which was effective alone, acted synergistically to reduce significantly HCG-stimulated progesterone production by 30%.	Progesterone	132-144	interleukin 1 alpha	Homo sapiens	13-17
1357034-8	1992	Ocular cells were also stimulated with PMA and shown to produce IL-1.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	64-68
1464470-4	1992	Ebselen was found to dose dependently inhibit the adhesion of PMNL to IL-1 activated endothelium and to inhibit transendothelial PMNL migration induced by IL-1 alpha, and TNF alpha with an IC50 value of 28 microM.	ebselen	0-7	interleukin 1 alpha	Homo sapiens	70-74
1464470-4	1992	Ebselen was found to dose dependently inhibit the adhesion of PMNL to IL-1 activated endothelium and to inhibit transendothelial PMNL migration induced by IL-1 alpha, and TNF alpha with an IC50 value of 28 microM.	ebselen	0-7	interleukin 1 alpha	Homo sapiens	155-165
1404592-1	1992	Oxygen radical scavengers, such as dithiocarbamates and cysteine derivatives, inhibit activation of the ubiquitous transcription factor nuclear factor kappa B (NF-kappa B) after treatment of cells with tumor necrosis factor, phorbol ester, and interleukin-1.	Reactive Oxygen Species	0-14	interleukin 1 alpha	Homo sapiens	244-257
1331399-0	1992	Characterization of [3H]morphine binding to interleukin-1-activated thymocytes.	Tritium	21-23	interleukin 1 alpha	Homo sapiens	44-57
1404592-1	1992	Oxygen radical scavengers, such as dithiocarbamates and cysteine derivatives, inhibit activation of the ubiquitous transcription factor nuclear factor kappa B (NF-kappa B) after treatment of cells with tumor necrosis factor, phorbol ester, and interleukin-1.	dithiocarbamates	35-51	interleukin 1 alpha	Homo sapiens	244-257
1331399-0	1992	Characterization of [3H]morphine binding to interleukin-1-activated thymocytes.	Morphine	24-32	interleukin 1 alpha	Homo sapiens	44-57
1331399-1	1992	We have previously reported that interleukin-1-induced proliferation of thymocytes is accompanied by the appearance of [3H]morphine binding sites on these cells.	Tritium	120-122	interleukin 1 alpha	Homo sapiens	33-46
1404592-1	1992	Oxygen radical scavengers, such as dithiocarbamates and cysteine derivatives, inhibit activation of the ubiquitous transcription factor nuclear factor kappa B (NF-kappa B) after treatment of cells with tumor necrosis factor, phorbol ester, and interleukin-1.	Cysteine	56-64	interleukin 1 alpha	Homo sapiens	244-257
1331399-1	1992	We have previously reported that interleukin-1-induced proliferation of thymocytes is accompanied by the appearance of [3H]morphine binding sites on these cells.	Morphine	123-131	interleukin 1 alpha	Homo sapiens	33-46
1331399-5	1992	These [3H]morphine binding sites may mediate a negative feedback effect on interleukin-1-induced proliferation of thymocytes in vivo.	Tritium	7-9	interleukin 1 alpha	Homo sapiens	75-88
1404592-1	1992	Oxygen radical scavengers, such as dithiocarbamates and cysteine derivatives, inhibit activation of the ubiquitous transcription factor nuclear factor kappa B (NF-kappa B) after treatment of cells with tumor necrosis factor, phorbol ester, and interleukin-1.	Phorbol Esters	225-238	interleukin 1 alpha	Homo sapiens	244-257
1331399-5	1992	These [3H]morphine binding sites may mediate a negative feedback effect on interleukin-1-induced proliferation of thymocytes in vivo.	Morphine	10-18	interleukin 1 alpha	Homo sapiens	75-88
1434539-8	1992	Slight but significant transendothelial migration of 51Cr-labeled PMNL was induced by alpha-thrombin (7.4 +/- 0.6% of cells added, unstimulated = 1.9 +/- 0.4%), although this response was less than that induced by f-norLeu-Leu-Phe (17%), IL-1 alpha (29%) or TNF-alpha (21%).	Chromium-51	53-57	interleukin 1 alpha	Homo sapiens	238-248
1491385-1	1992	The effect of methotrexate (MTX) treatment on patients with rheumatoid arthritis on interleukin 1 (IL-1) was evaluated.	Methotrexate	14-26	interleukin 1 alpha	Homo sapiens	84-104
1491385-1	1992	The effect of methotrexate (MTX) treatment on patients with rheumatoid arthritis on interleukin 1 (IL-1) was evaluated.	Methotrexate	28-31	interleukin 1 alpha	Homo sapiens	84-104
1491385-5	1992	Four patients manifested a sharp decrease in IL-1 production 6 weeks after MTX administration associated with a decrease in the number of painful but not swollen joints.	Methotrexate	75-78	interleukin 1 alpha	Homo sapiens	45-49
1491385-7	1992	Our results suggest that MTX may affect IL-1 production and IL-1 mediated events in some patients.	Methotrexate	25-28	interleukin 1 alpha	Homo sapiens	40-44
1434539-9	1992	alpha-Thrombin enhanced the initial rate of IL-1, TNF-alpha and f-norLeu-Leu-Phe induced PMNL transendothelial migration in an additive or supradditive manner (e.g., with IL-1 alpha+alpha-thrombin, migration was 58% greater than additive at 15 to 30 minutes, p &lt; 0.001).	methylphenyl carbinol	0-5	interleukin 1 alpha	Homo sapiens	44-48
1491385-7	1992	Our results suggest that MTX may affect IL-1 production and IL-1 mediated events in some patients.	Methotrexate	25-28	interleukin 1 alpha	Homo sapiens	60-64
1434539-9	1992	alpha-Thrombin enhanced the initial rate of IL-1, TNF-alpha and f-norLeu-Leu-Phe induced PMNL transendothelial migration in an additive or supradditive manner (e.g., with IL-1 alpha+alpha-thrombin, migration was 58% greater than additive at 15 to 30 minutes, p &lt; 0.001).	methylphenyl carbinol	0-5	interleukin 1 alpha	Homo sapiens	171-181
1328386-9	1992	Addition of anti-sense oligonucleotides directed to the mRNA of IL-1 alpha, IL-6, and TNF-alpha, respectively, resulted in growth arrest and cell death.	Oligonucleotides	23-39	interleukin 1 alpha	Homo sapiens	64-74
1434539-9	1992	alpha-Thrombin enhanced the initial rate of IL-1, TNF-alpha and f-norLeu-Leu-Phe induced PMNL transendothelial migration in an additive or supradditive manner (e.g., with IL-1 alpha+alpha-thrombin, migration was 58% greater than additive at 15 to 30 minutes, p &lt; 0.001).	Phenylalanine	77-80	interleukin 1 alpha	Homo sapiens	44-48
1434539-9	1992	alpha-Thrombin enhanced the initial rate of IL-1, TNF-alpha and f-norLeu-Leu-Phe induced PMNL transendothelial migration in an additive or supradditive manner (e.g., with IL-1 alpha+alpha-thrombin, migration was 58% greater than additive at 15 to 30 minutes, p &lt; 0.001).	Phenylalanine	77-80	interleukin 1 alpha	Homo sapiens	171-181
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	101-104	interleukin 1 alpha	Homo sapiens	216-220
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	tetradecanoylphorbol 13-acetate	20-51	interleukin 1 alpha	Homo sapiens	102-112
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 alpha	Homo sapiens	102-112
1384479-6	1992	The stimulatory effect of both IL-1 alpha and IL-1 beta and the synergistical stimulation with TPA were completely abrogated by 10 ng/ml TGF-beta 1 or 1 microM dexamethasone.	Dexamethasone	160-173	interleukin 1 alpha	Homo sapiens	31-41
1390947-0	1992	Aurothioglucose inhibits induced NF-kB and AP-1 activity by acting as an IL-1 functional antagonist.	Aurothioglucose	0-15	interleukin 1 alpha	Homo sapiens	73-77
1390947-3	1992	We have studied the effects of indomethacin, dexamethasone and aurothioglucose (which have been used in the treatment of patients affected by rheumatoid arthritis) in the IL-1 inducible CAT assay.	Indomethacin	31-43	interleukin 1 alpha	Homo sapiens	171-175
1390947-3	1992	We have studied the effects of indomethacin, dexamethasone and aurothioglucose (which have been used in the treatment of patients affected by rheumatoid arthritis) in the IL-1 inducible CAT assay.	Dexamethasone	45-58	interleukin 1 alpha	Homo sapiens	171-175
1390947-3	1992	We have studied the effects of indomethacin, dexamethasone and aurothioglucose (which have been used in the treatment of patients affected by rheumatoid arthritis) in the IL-1 inducible CAT assay.	Aurothioglucose	63-78	interleukin 1 alpha	Homo sapiens	171-175
1390947-4	1992	We show that aurothioglucose or dexamethasone is able to inhibit IL-1 induced CAT activity whereas a non-steroidal anti-inflammatory drug (indomethacin) is inactive.	Aurothioglucose	13-28	interleukin 1 alpha	Homo sapiens	65-69
1390947-4	1992	We show that aurothioglucose or dexamethasone is able to inhibit IL-1 induced CAT activity whereas a non-steroidal anti-inflammatory drug (indomethacin) is inactive.	Dexamethasone	32-45	interleukin 1 alpha	Homo sapiens	65-69
1390947-5	1992	Order of addition experiments indicate that aurothioglucose, which has disease-modifying activity in treated patients, acts as an IL-1 functional antagonist in this system.	Aurothioglucose	44-59	interleukin 1 alpha	Homo sapiens	130-134
1329566-7	1992	Pretreatment with the cyclooxygenase inhibitor indomethacin markedly reduced the increase in aldosterone plasma levels and PRA induced by IL-1, indicating that prostaglandins are involved in these effects of the cytokine.	Indomethacin	47-59	interleukin 1 alpha	Homo sapiens	138-142
1329566-7	1992	Pretreatment with the cyclooxygenase inhibitor indomethacin markedly reduced the increase in aldosterone plasma levels and PRA induced by IL-1, indicating that prostaglandins are involved in these effects of the cytokine.	Prostaglandins	160-174	interleukin 1 alpha	Homo sapiens	138-142
1394436-13	1992	AG126 enhanced IFN-gamma, IL-1, and IL-6 production in PBM that were costimulated with the stress stimuli heat shock and phenylarsine oxide.	AG 127	0-5	interleukin 1 alpha	Homo sapiens	26-30
1468114-0	1992	Reduction of the acetylcholine-induced K+ current in identified Aplysia neurons by human interleukin-1 and interleukin-2.	Acetylcholine	17-30	interleukin 1 alpha	Homo sapiens	89-102
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	101-104	interleukin 1 alpha	Homo sapiens	249-253
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	216-220
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	249-253
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	216-220
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	249-253
1445798-5	1992	Although the levels of other fos-related mRNAs were also elevated, their maximal induction was delayed by approximately 5 h. IL-1 alone had little or no effect, but enhanced TPA induced transcription and steady-state levels of these mRNAs.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	125-129
1468114-2	1992	Effects of bath-applied recombinant human interleukin-1 (rhIL-1) and interleukin-2 (rhIL-2) on the acetylcholine (ACh)-induced K+ current recorded from identified neurons (R9 and R10) of Aplysia kurodai were investigated with voltage-clamp and pressure ejection techniques.	Acetylcholine	99-112	interleukin 1 alpha	Homo sapiens	42-64
1468114-10	1992	These results suggest that the immunomodulators, IL-1 and IL-2, can modulate the ACh-induced response in the nervous system.	Acetylcholine	81-84	interleukin 1 alpha	Homo sapiens	49-53
1445798-7	1992	These findings indicate that the synergistic effect of IL-1 and TPA on AP-1 mediated gene expression is due, in part, to the ability of IL-1 to enhance the expression of genes encoding specific AP-1 transcription factor components.	Tetradecanoylphorbol Acetate	64-67	interleukin 1 alpha	Homo sapiens	136-140
1526345-6	1992	Other cytokines including IL-1, IL-6, and alpha-interferon increase hepatic de novo fatty acid synthesis.	Fatty Acids	84-94	interleukin 1 alpha	Homo sapiens	26-30
1396721-1	1992	Lapine synovial fibroblasts produce prostaglandin E2 (PGE2) and neutral metalloproteinases in response to phorbol 12-myristate 13-acetate (PMA), human recombinant interleukin-1 (hrIL-1) and, in an autocrine fashion, in response to partially purified preparations of their own cytokines known as cell-activating factors (CAF).	Dinoprostone	36-52	interleukin 1 alpha	Homo sapiens	163-176
1396721-1	1992	Lapine synovial fibroblasts produce prostaglandin E2 (PGE2) and neutral metalloproteinases in response to phorbol 12-myristate 13-acetate (PMA), human recombinant interleukin-1 (hrIL-1) and, in an autocrine fashion, in response to partially purified preparations of their own cytokines known as cell-activating factors (CAF).	Dinoprostone	54-58	interleukin 1 alpha	Homo sapiens	163-176
1396721-1	1992	Lapine synovial fibroblasts produce prostaglandin E2 (PGE2) and neutral metalloproteinases in response to phorbol 12-myristate 13-acetate (PMA), human recombinant interleukin-1 (hrIL-1) and, in an autocrine fashion, in response to partially purified preparations of their own cytokines known as cell-activating factors (CAF).	hril	178-182	interleukin 1 alpha	Homo sapiens	163-176
1478189-2	1992	IL-1 significantly reduced serum insulin levels in ADX rats only, while it similarly decreased plasma glucose levels.	Glucose	102-109	interleukin 1 alpha	Homo sapiens	0-4
1281784-5	1992	The most potent combination of growth factors that we examined, interleukin 1 (IL-1)/IL-3/IL-6/MGF, resulted in the conferral of G418 resistance to 45% of progenitors and long-term culture-initiating cells.	antibiotic G 418	129-133	interleukin 1 alpha	Homo sapiens	64-83
1478189-6	1992	The present study immunohistochemically supported our working hypothesis that the withdrawal of adrenal steroids by adrenalectomy enhances the islet cell sensitivity to exogenous administration of IL-1.	Steroids	104-112	interleukin 1 alpha	Homo sapiens	197-201
1401082-2	1992	We characterized the mechanisms by which recombinant (r) tumor necrosis factor (TNF), IFN-gamma, and IL-1, alone and in combination, regulate human lung fibroblast hyaluronic acid (HA) production.	Hyaluronic Acid	164-179	interleukin 1 alpha	Homo sapiens	101-105
1409612-4	1992	IL-1ra blocked the increased body temperature and oxygen consumption induced by injection of recombinant human IL-1 only when both cytokines were administered i.p.	Oxygen	50-56	interleukin 1 alpha	Homo sapiens	0-4
1401082-2	1992	We characterized the mechanisms by which recombinant (r) tumor necrosis factor (TNF), IFN-gamma, and IL-1, alone and in combination, regulate human lung fibroblast hyaluronic acid (HA) production.	Hyaluronic Acid	181-183	interleukin 1 alpha	Homo sapiens	101-105
1456174-9	1992	Superoxide dismutase and glutathione peroxidase prevented H/R-induced IL-1 and IL-6 increase.	r	60-61	interleukin 1 alpha	Homo sapiens	70-74
1387585-0	1992	Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide: obligatory role of interleukin 1 in the generation of lymphokine-activated killer cells.	Oligonucleotides	74-89	interleukin 1 alpha	Homo sapiens	23-36
1387585-6	1992	However, a synthetic IL-1 beta antisense oligonucleotide, which could specifically inhibit intracellular IL-1 beta protein expression as detected by Western blot, was more effective in reducing LAK killing, but it could not suppress the cytotoxicity generated by exogenous IL-1 plus IL-2.	Oligonucleotides	41-56	interleukin 1 alpha	Homo sapiens	21-25
1456174-10	1992	These results constitute the first demonstration that H/R stimulates HUVEC to promote IL-1 and IL-6 production and strongly suggest a role for oxygen-derived free radicals in the cytokine synthesis.	r	56-57	interleukin 1 alpha	Homo sapiens	86-90
1456177-0	1992	The effect of hyaluronan on interleukin-1 alpha-induced prostaglandin E2 production in human osteoarthritic synovial cells.	Hyaluronic Acid	14-24	interleukin 1 alpha	Homo sapiens	28-47
1456177-0	1992	The effect of hyaluronan on interleukin-1 alpha-induced prostaglandin E2 production in human osteoarthritic synovial cells.	Dinoprostone	56-72	interleukin 1 alpha	Homo sapiens	28-47
1456177-1	1992	An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.	Hyaluronic Acid	36-46	interleukin 1 alpha	Homo sapiens	55-74
1456177-1	1992	An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.	Dinoprostone	83-99	interleukin 1 alpha	Homo sapiens	55-74
1456177-1	1992	An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	55-74
1456177-1	1992	An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.	Dinoprostone	172-176	interleukin 1 alpha	Homo sapiens	55-74
1477353-2	1992	It was established that IL1a leads to cartilage degradation as shown by an increase of sulphated glycosaminoglycans (sGAG) in culture medium and their decrease in tissue, inhibition of proteoglycan (PG) synthesis by chondrocytes.	Glycosaminoglycans	97-115	interleukin 1 alpha	Homo sapiens	24-28
1337984-3	1992	The level of kinase induction correlated well with dose-response curves for two characteristic IL-1-induced responses, PGE2 and IL-6 production.	Dinoprostone	119-123	interleukin 1 alpha	Homo sapiens	95-99
1337984-6	1992	Even after 2 hours exposure, the ability of IL-1 to induce IL-6 or PGE2 was still IL-1ra-inhibitable by more than 80%, suggesting that events downstream of, or parallel to MAP-kinase activation, requiring the continual formation of new IL-1 receptor complexes, are needed to fully elicit these responses.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	44-48
1477295-0	1992	The effects of interleukin-1 on pancreatic beta cell function in vitro depend on the glucose concentration.	Glucose	85-92	interleukin 1 alpha	Homo sapiens	15-28
1478705-7	1992	Although pretreatment of monocytes for 2 h with 1,25-(OH)2D3 caused significant reduction in the release of IL-1 alpha and TNF alpha, reconstitution of monocyte-depleted cultures with similarly treated monocytes had no inhibitory effect on the proliferative response.	Calcitriol	48-60	interleukin 1 alpha	Homo sapiens	108-118
1505642-3	1992	In this study, we report on the ability of IL-1 and TNF-alpha to protect hematopoietic cells capable of repopulating irradiated long-term bone marrow stromal cultures from 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	172-201	interleukin 1 alpha	Homo sapiens	43-47
1505642-3	1992	In this study, we report on the ability of IL-1 and TNF-alpha to protect hematopoietic cells capable of repopulating irradiated long-term bone marrow stromal cultures from 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	203-207	interleukin 1 alpha	Homo sapiens	43-47
1510717-0	1992	In human monocytes interleukin-1 stimulates a phospholipase C active on phosphatidylcholine and inactive on phosphatidylinositol.	Phosphatidylcholines	72-91	interleukin 1 alpha	Homo sapiens	19-32
1325990-2	1992	Exposure of cells to hypoxia (pO2 approximately 14 torr) followed by reoxygenation led to significant release of IL-1 only from the mononuclear phagocytes.	PO-2	30-33	interleukin 1 alpha	Homo sapiens	113-117
1325990-3	1992	Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as the time in reoxygenation (maximal IL-1 release at 6-9 h).	Oxygen	41-47	interleukin 1 alpha	Homo sapiens	15-19
1325990-3	1992	Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as the time in reoxygenation (maximal IL-1 release at 6-9 h).	PO-2	98-102	interleukin 1 alpha	Homo sapiens	15-19
1325990-5	1992	IL-1 released during reoxygenation was newly synthesized, and its production was triggered by the generation of oxygen free radicals, as it could be blocked by the addition of either allopurinol or free radical scavengers to cultures and could be stimulated in part by low concentrations of hydrogen peroxide or xanthine/xanthine oxidase.	oxygen free radicals	112-132	interleukin 1 alpha	Homo sapiens	0-4
1325990-5	1992	IL-1 released during reoxygenation was newly synthesized, and its production was triggered by the generation of oxygen free radicals, as it could be blocked by the addition of either allopurinol or free radical scavengers to cultures and could be stimulated in part by low concentrations of hydrogen peroxide or xanthine/xanthine oxidase.	Allopurinol	183-194	interleukin 1 alpha	Homo sapiens	0-4
1325990-5	1992	IL-1 released during reoxygenation was newly synthesized, and its production was triggered by the generation of oxygen free radicals, as it could be blocked by the addition of either allopurinol or free radical scavengers to cultures and could be stimulated in part by low concentrations of hydrogen peroxide or xanthine/xanthine oxidase.	Hydrogen Peroxide	291-308	interleukin 1 alpha	Homo sapiens	0-4
1299751-7	1992	Immediately after praziquantel therapy IL-1 production fell from Kact.	Praziquantel	18-30	interleukin 1 alpha	Homo sapiens	39-43
1510717-1	1992	Interleukin-1 (IL-1) can initiate the synthesis of prostaglandins which in turn act as endogenous modulators of IL-1 production.	Prostaglandins	51-65	interleukin 1 alpha	Homo sapiens	0-13
1510717-1	1992	Interleukin-1 (IL-1) can initiate the synthesis of prostaglandins which in turn act as endogenous modulators of IL-1 production.	Prostaglandins	51-65	interleukin 1 alpha	Homo sapiens	15-19
1510717-1	1992	Interleukin-1 (IL-1) can initiate the synthesis of prostaglandins which in turn act as endogenous modulators of IL-1 production.	Prostaglandins	51-65	interleukin 1 alpha	Homo sapiens	112-116
1510717-6	1992	Studies have shown that IL-1 does not activate the IP pathway, but it primarily stimulates a PLC linked to phosphatidylethanolamine in cultured rat mesangial cells, and a PLC linked to PC in Jurkart cells.	phosphatidylethanolamine	107-131	interleukin 1 alpha	Homo sapiens	24-28
1510717-9	1992	In contrast, in cells labeled with [3H]AA, IL-1 causes the formation of DAG associated with the hydrolysis of PC.	Tritium	36-38	interleukin 1 alpha	Homo sapiens	43-47
1510717-9	1992	In contrast, in cells labeled with [3H]AA, IL-1 causes the formation of DAG associated with the hydrolysis of PC.	Diglycerides	72-75	interleukin 1 alpha	Homo sapiens	43-47
1510717-9	1992	In contrast, in cells labeled with [3H]AA, IL-1 causes the formation of DAG associated with the hydrolysis of PC.	Phosphatidylcholines	110-112	interleukin 1 alpha	Homo sapiens	43-47
1379083-0	1992	Specific repression of granulocyte-macrophage and granulocyte colony-stimulating factor gene expression in interleukin-1-stimulated endothelial cells with antisense oligodeoxynucleotides.	Oligodeoxyribonucleotides	165-186	interleukin 1 alpha	Homo sapiens	107-120
1502195-10	1992	IL-1 was shown to stimulate the secretion of thymulin as measured both by its ability to stimulate induction of IL-2 receptor-positive lymphocytes from human peripheral blood lymphocytes and by the azathioprine-sensitive rosette assay.	Azathioprine	198-210	interleukin 1 alpha	Homo sapiens	0-4
1502195-11	1992	In addition, the zinc-thymulin complex in the presence, but not absence, of IL-1 stimulates nuclear protein kinase C in isolated lymphocyte nuclei.	Thymic Factor, Circulating	22-30	interleukin 1 alpha	Homo sapiens	76-80
1358037-7	1992	In the group treated with sulphasalazine there was a progressive and significant decline in serum IL-1 alpha, IL-1 beta, and TNF alpha levels over the six month period (median levels at six months were &lt; 0.1, 0.12, and 0.44 ng/ml respectively).	Sulfasalazine	26-40	interleukin 1 alpha	Homo sapiens	98-108
1330055-0	1992	On the signal transducing mechanisms involved in the synergistic interaction between interleukin-1 and bradykinin on prostaglandin biosynthesis in human gingival fibroblasts.	Prostaglandins	117-130	interleukin 1 alpha	Homo sapiens	85-98
1483116-3	1992	Administration of interleukin-1 alpha to cultured osteoblasts produce an increase in cellular proliferation as suggested by 3H-thymidine incorporation and cell growth studies.	Tritium	124-126	interleukin 1 alpha	Homo sapiens	18-37
1322806-4	1992	IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures.	Dinoprostone	151-167	interleukin 1 alpha	Homo sapiens	0-10
1322806-4	1992	IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures.	Dinoprostone	169-173	interleukin 1 alpha	Homo sapiens	0-10
1322806-6	1992	Recombinant human interleukin-6 (IL-6) caused a concentration-dependent (6-200 ng/ml) potentiation of IL-1-stimulated neutral proteinase and PGE2 production by BNC.	Dinoprostone	141-145	interleukin 1 alpha	Homo sapiens	102-106
1483116-3	1992	Administration of interleukin-1 alpha to cultured osteoblasts produce an increase in cellular proliferation as suggested by 3H-thymidine incorporation and cell growth studies.	Thymidine	127-136	interleukin 1 alpha	Homo sapiens	18-37
1426065-3	1992	The combination of cycloheximide and recombinant interleukin-1 caused a 14-fold enhancement of interleukin-1 alpha and interleukin-1 beta mRNA expression above that observed after cells were stimulated with interleukin-1 alone.	Cycloheximide	19-32	interleukin 1 alpha	Homo sapiens	95-108
1638519-2	1992	The results presented herein demonstrate that the pretreatment of mice with recombinant human interleukin 1 alpha (rhIL-1 alpha) protects mice from the lethal effects of several myelotoxic chemotherapeutic drugs, including 5-fluorouracil (5FUra), cyclophosphamide, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and 1,3-bis-(2-chloroethyl)-1-nitrosourea.	Fluorouracil	239-244	interleukin 1 alpha	Homo sapiens	94-113
1638519-2	1992	The results presented herein demonstrate that the pretreatment of mice with recombinant human interleukin 1 alpha (rhIL-1 alpha) protects mice from the lethal effects of several myelotoxic chemotherapeutic drugs, including 5-fluorouracil (5FUra), cyclophosphamide, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and 1,3-bis-(2-chloroethyl)-1-nitrosourea.	Cyclophosphamide	247-263	interleukin 1 alpha	Homo sapiens	94-113
1638519-2	1992	The results presented herein demonstrate that the pretreatment of mice with recombinant human interleukin 1 alpha (rhIL-1 alpha) protects mice from the lethal effects of several myelotoxic chemotherapeutic drugs, including 5-fluorouracil (5FUra), cyclophosphamide, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and 1,3-bis-(2-chloroethyl)-1-nitrosourea.	Carboplatin	265-315	interleukin 1 alpha	Homo sapiens	94-113
1638519-2	1992	The results presented herein demonstrate that the pretreatment of mice with recombinant human interleukin 1 alpha (rhIL-1 alpha) protects mice from the lethal effects of several myelotoxic chemotherapeutic drugs, including 5-fluorouracil (5FUra), cyclophosphamide, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and 1,3-bis-(2-chloroethyl)-1-nitrosourea.	Carmustine	325-362	interleukin 1 alpha	Homo sapiens	94-113
1322303-3	1992	IL-1 induced c-jun gene transcription and mRNA expression by means of a pathway dependent on protein tyrosine kinase activity since tyrphostin, a specific inhibitor of tyrosine kinase, inhibited this induction.	Tyrphostins	132-142	interleukin 1 alpha	Homo sapiens	0-4
1322303-6	1992	Accumulation of intracellular cAMP generated by IL-1 through the 80-kDa IL-1R negatively regulated c-fos expression which was induced by IL-1 through PKC activation.	Cyclic AMP	30-34	interleukin 1 alpha	Homo sapiens	48-52
1322303-6	1992	Accumulation of intracellular cAMP generated by IL-1 through the 80-kDa IL-1R negatively regulated c-fos expression which was induced by IL-1 through PKC activation.	Cyclic AMP	30-34	interleukin 1 alpha	Homo sapiens	72-76
1638519-2	1992	The results presented herein demonstrate that the pretreatment of mice with recombinant human interleukin 1 alpha (rhIL-1 alpha) protects mice from the lethal effects of several myelotoxic chemotherapeutic drugs, including 5-fluorouracil (5FUra), cyclophosphamide, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and 1,3-bis-(2-chloroethyl)-1-nitrosourea.	Fluorouracil	223-237	interleukin 1 alpha	Homo sapiens	94-113
1358619-8	1992	Using phorbol ester-activated, 51Cr-labelled peripheral blood mononuclear cells (PBMCs) in a cell adhesion assay, we demonstrated potent adhesive activity of ICAM-1 in GO-OF pretreated with IL-1a, TNFa, IFNg or Graves" IgGs, while all other compounds did not affect PBMC adhesion to GO-OF.	Phorbol Esters	6-19	interleukin 1 alpha	Homo sapiens	190-195
1426065-3	1992	The combination of cycloheximide and recombinant interleukin-1 caused a 14-fold enhancement of interleukin-1 alpha and interleukin-1 beta mRNA expression above that observed after cells were stimulated with interleukin-1 alone.	Cycloheximide	19-32	interleukin 1 alpha	Homo sapiens	95-108
1504058-8	1992	It is suggested from these results that the cytotoxicity of LAMs is regulated by CSF-1, IL-1, IFN-gamma, and TNF, and that the production of cytotoxic molecules is involved in cell-mediated killing by LAMs.	lipoarabinomannan	60-64	interleukin 1 alpha	Homo sapiens	88-92
1639344-6	1992	In addition, ursodeoxycholic acid suppressed the concanavalin A-induced thymocyte proliferation mediated by interleukin-1.	Ursodeoxycholic Acid	13-33	interleukin 1 alpha	Homo sapiens	108-121
1322431-4	1992	Both IL-1 alpha and beta inhibited [3H] thymidine uptake into NPA cell DNA in a dose- and time-dependent manner at concentrations ranging from 5 x 10(2) to 10(5) U/L; 10(5) U/L of IL-1 suppressed DNA synthesis by more than 40% of control.	Tritium	36-38	interleukin 1 alpha	Homo sapiens	5-15
1322431-4	1992	Both IL-1 alpha and beta inhibited [3H] thymidine uptake into NPA cell DNA in a dose- and time-dependent manner at concentrations ranging from 5 x 10(2) to 10(5) U/L; 10(5) U/L of IL-1 suppressed DNA synthesis by more than 40% of control.	Thymidine	40-49	interleukin 1 alpha	Homo sapiens	5-15
1506211-6	1992	In cell culture studies it has been shown that macrophages/monocytes release IL1, IL6 and TNF after ingestion of silica, which affects fibroblasts, T-helper cells and endothelial cells.	Silicon Dioxide	113-119	interleukin 1 alpha	Homo sapiens	77-80
1391721-1	1992	The effect of interleukin-1 alpha (IL-1) on the synthesis of glomerular basement membrane heparan sulfate-proteoglycan (HS-PG) was investigated.	Hydrogen	120-122	interleukin 1 alpha	Homo sapiens	35-39
1330002-3	1992	SDS-PAGE indicated that these biological activities were associated with the adaptive release of tunicate IL1-like (tunicate IL-1) molecules by stimulated hemocytes.	Sodium Dodecyl Sulfate	0-3	interleukin 1 alpha	Homo sapiens	106-109
1330002-3	1992	SDS-PAGE indicated that these biological activities were associated with the adaptive release of tunicate IL1-like (tunicate IL-1) molecules by stimulated hemocytes.	Sodium Dodecyl Sulfate	0-3	interleukin 1 alpha	Homo sapiens	125-129
1523264-3	1992	We report that pretreatment with ibuprofen significantly improved food intake and gastric emptying in IL-1 injected rats, but did not return them to control levels.	Ibuprofen	33-42	interleukin 1 alpha	Homo sapiens	102-106
1420598-9	1992	This study demonstrates that glycosylation of the extracellular domain of the IL-1RtI is due to N-linked carbohydrates, that the degree of glycosylation can vary in cells of different lineage, and that this N-linked glycosylation appears to be essential for optimal binding and activity of IL-1 to its type I receptor.	n-linked carbohydrates	96-118	interleukin 1 alpha	Homo sapiens	78-82
1420598-9	1992	This study demonstrates that glycosylation of the extracellular domain of the IL-1RtI is due to N-linked carbohydrates, that the degree of glycosylation can vary in cells of different lineage, and that this N-linked glycosylation appears to be essential for optimal binding and activity of IL-1 to its type I receptor.	Nitrogen	96-97	interleukin 1 alpha	Homo sapiens	78-82
1523264-4	1992	We conclude that PGs mediate, at least in part, IL-1 induced gastroparesis.	Phosphatidylglycerols	17-20	interleukin 1 alpha	Homo sapiens	48-52
1442930-0	1992	Transforming growth factor-beta opposes the stimulatory effects of interleukin-1 and tumor necrosis factor on amnion cell prostaglandin E2 production: implication for preterm labor.	Dinoprostone	122-138	interleukin 1 alpha	Homo sapiens	67-106
1425935-5	1992	Interleukin-1, interleukin-2 production and interleukin-2 receptor expression were all reduced in the presence of scoparone.	scoparone	114-123	interleukin 1 alpha	Homo sapiens	0-13
1322666-4	1992	DDTC treatment also increased interleukin-alpha (IL-1 alpha), IL-1 beta, and tumor necrosis factor (TNF) expression in these cells.	Ditiocarb	0-4	interleukin 1 alpha	Homo sapiens	49-59
1322666-9	1992	These data suggest that the myeloprotective effects of DDTC may be mediated, at least in part, by the induction of TNF, IL-1 alpha, and IL-1 beta.	Ditiocarb	55-59	interleukin 1 alpha	Homo sapiens	120-130
1382370-0	1992	Effects of human recombinant IL-1 on d-tubocurarine-induced histamine release from isolated rat peritoneal mast cells.	Tubocurarine	37-51	interleukin 1 alpha	Homo sapiens	29-33
1382370-0	1992	Effects of human recombinant IL-1 on d-tubocurarine-induced histamine release from isolated rat peritoneal mast cells.	Histamine	60-69	interleukin 1 alpha	Homo sapiens	29-33
1386807-3	1992	When enriched T cells were tested in the presence of interleukin-1 alpha (0 to 100 U/ml, incorporation of 3H-thymidine was greater in those cells stimulated by ALG than by PHA.	3h-thymidine	106-118	interleukin 1 alpha	Homo sapiens	53-72
1636747-1	1992	The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), potently induce prostaglandin formation in glomerular mesangial cells.	Prostaglandins	85-98	interleukin 1 alpha	Homo sapiens	30-34
1636747-6	1992	IL-1-induced COX mass was maintained at an increased level for at least 48 h. The glucocorticoid dexamethasone (DEX) virtually abolished prostaglandin production and blocked cytokine induction of COX activity and mass.	Dexamethasone	97-110	interleukin 1 alpha	Homo sapiens	0-4
1636747-6	1992	IL-1-induced COX mass was maintained at an increased level for at least 48 h. The glucocorticoid dexamethasone (DEX) virtually abolished prostaglandin production and blocked cytokine induction of COX activity and mass.	Dexamethasone	112-115	interleukin 1 alpha	Homo sapiens	0-4
1504741-4	1992	IL-1 alpha (1.5-6.0 ng ml-1) and IL-1 beta (30-300 pg ml-1), dose-dependently, stimulated PGE2 formation, in 24 h cultures, with IL-beta being the most potent agonist.	Dinoprostone	90-94	interleukin 1 alpha	Homo sapiens	0-10
1504741-6	1992	PHT (2.5-20 micrograms ml-1) did not induce PGE2 formation itself but potentiated IL-1 alpha- and IL-1 beta-induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentrations of both IL-1 and PHT.	Dinoprostone	116-120	interleukin 1 alpha	Homo sapiens	82-92
1353743-0	1992	Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.	Aminophenols	10-22	interleukin 1 alpha	Homo sapiens	52-65
1353743-0	1992	Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.	Aminosalicylic Acid	24-29	interleukin 1 alpha	Homo sapiens	52-65
1353743-0	1992	Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.	Aminosalicylic Acid	34-39	interleukin 1 alpha	Homo sapiens	52-65
1353743-2	1992	Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid.	Aminosalicylic Acid	30-35	interleukin 1 alpha	Homo sapiens	133-146
1353743-2	1992	Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid.	Aminosalicylic Acid	39-44	interleukin 1 alpha	Homo sapiens	133-146
1353743-2	1992	Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid.	Aminosalicylic Acid	95-100	interleukin 1 alpha	Homo sapiens	133-146
1353743-4	1992	Interleukin-1 content in tissue cultured in the presence of 5-ASA (100 micrograms/ml) was two-thirds of its content in tissue cultured in drug free medium and its release into the medium was decreased by 50%.	Aminosalicylic Acid	60-65	interleukin 1 alpha	Homo sapiens	0-13
1353743-7	1992	We conclude that pharmacological suppression of colonic interleukin-1 generation may be one, although not the sole mechanism to explain the therapeutic efficacy of 5-ASA in the treatment of inflammatory bowel disease.	Aminosalicylic Acid	164-169	interleukin 1 alpha	Homo sapiens	56-69
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	54-64
1321178-0	1992	Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells.	Nedocromil	21-38	interleukin 1 alpha	Homo sapiens	46-59
1377699-3	1992	The addition of IL-1 to these cultures increased the level of CSA and, specifically, of granulocyte colony-stimulating factor (G-CSF) released.	Cyclosporine	62-65	interleukin 1 alpha	Homo sapiens	16-20
1377699-4	1992	Anti-GM-CSF antibody neutralized BPA and CSA in normal naive LTC CM but only the CSA in the CM from IL-1-stimulated LTC.	Cyclosporine	81-84	interleukin 1 alpha	Homo sapiens	100-104
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	54-64
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
1607919-4	1992	A second group of patients received indomethacin plus IL-1 alpha based on preclinical studies, which indicated that indomethacin could abrogate IL-1 alpha-induced hypotension; however, the MTD of IL-1 alpha plus indomethacin was 0.1 microgram/kg lower than IL-1 alpha alone.	Indomethacin	116-128	interleukin 1 alpha	Homo sapiens	144-154
20732127-6	1992	Time- and dose-dependent release of the pro-inflammatory mediators, prostaglandin E2, prostacyclin and interleukin-1-alpha (IL-1alpha) was seen in LSE exposed to two known chemical irritants, morpholine and hydroxylamine sulphate, but not in LSE exposed to a minimally irritating test sample.	morpholine	192-202	interleukin 1 alpha	Homo sapiens	103-122
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Phenytoin	42-45	interleukin 1 alpha	Homo sapiens	55-65
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Dinoprostone	135-139	interleukin 1 alpha	Homo sapiens	55-65
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Phenytoin	187-190	interleukin 1 alpha	Homo sapiens	55-65
1641068-3	1992	Injection of 6-OHDA into the PVN depleted its norepinephrine (NE) content by 85% and reduced by 80-82% the increase in plasma CS concentrations following intraperitoneal injection of recombinant human interleukin-1 alpha (IL-1), but did not affect the adrenocortical response to 20 min restraint.	Oxidopamine	13-19	interleukin 1 alpha	Homo sapiens	201-220
1641068-3	1992	Injection of 6-OHDA into the PVN depleted its norepinephrine (NE) content by 85% and reduced by 80-82% the increase in plasma CS concentrations following intraperitoneal injection of recombinant human interleukin-1 alpha (IL-1), but did not affect the adrenocortical response to 20 min restraint.	Oxidopamine	13-19	interleukin 1 alpha	Homo sapiens	222-226
1641068-5	1992	This lesion reduced the CS response to human IL-1 alpha by 82-86%, but did not alter that to 20 min restraint, although there was a nonsignificant decrease in the CS response following 3 min of restraint.	Corticosterone	24-26	interleukin 1 alpha	Homo sapiens	45-55
20732127-6	1992	Time- and dose-dependent release of the pro-inflammatory mediators, prostaglandin E2, prostacyclin and interleukin-1-alpha (IL-1alpha) was seen in LSE exposed to two known chemical irritants, morpholine and hydroxylamine sulphate, but not in LSE exposed to a minimally irritating test sample.	morpholine	192-202	interleukin 1 alpha	Homo sapiens	124-133
20732127-6	1992	Time- and dose-dependent release of the pro-inflammatory mediators, prostaglandin E2, prostacyclin and interleukin-1-alpha (IL-1alpha) was seen in LSE exposed to two known chemical irritants, morpholine and hydroxylamine sulphate, but not in LSE exposed to a minimally irritating test sample.	hydroxylamine sulphate	207-229	interleukin 1 alpha	Homo sapiens	103-122
20732127-6	1992	Time- and dose-dependent release of the pro-inflammatory mediators, prostaglandin E2, prostacyclin and interleukin-1-alpha (IL-1alpha) was seen in LSE exposed to two known chemical irritants, morpholine and hydroxylamine sulphate, but not in LSE exposed to a minimally irritating test sample.	hydroxylamine sulphate	207-229	interleukin 1 alpha	Homo sapiens	124-133
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	14-16	interleukin 1 alpha	Homo sapiens	230-243
1377908-0	1992	Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, inhibits induction of acute-phase proteins by interleukin-6 alone or in combination with interleukin-1 in human hepatoma cell lines.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	150-163
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	14-16	interleukin 1 alpha	Homo sapiens	245-249
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	230-243
1377908-1	1992	Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose-dependent manner (5-20 nM) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	245-249
1596568-2	1992	Exposure to IL-3, IL-7, IL-1, and IL-6 resulted in a mean 2.8-, 1.5-, 1.4-, and 1.6-fold stimulation of 3H-thymidine (3H-TdR) incorporation, respectively.	3h-thymidine	104-116	interleukin 1 alpha	Homo sapiens	24-28
1596568-2	1992	Exposure to IL-3, IL-7, IL-1, and IL-6 resulted in a mean 2.8-, 1.5-, 1.4-, and 1.6-fold stimulation of 3H-thymidine (3H-TdR) incorporation, respectively.	Tritium	104-106	interleukin 1 alpha	Homo sapiens	24-28
1599440-9	1992	Thus only 20% of the proteoglycans isolated from the medium of IL-1-treated cultures, compared with 39% for control cultures, had the capacity to form high-M(r) aggregates with hyaluronic acid.	Hyaluronic Acid	177-192	interleukin 1 alpha	Homo sapiens	63-67
1610348-5	1992	When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling.	Cycloheximide	52-65	interleukin 1 alpha	Homo sapiens	5-15
1610348-5	1992	When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling.	Sulfur-35	155-158	interleukin 1 alpha	Homo sapiens	5-15
1610348-5	1992	When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling.	Methionine	160-170	interleukin 1 alpha	Homo sapiens	5-15
1610348-5	1992	When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling.	Phosphorus-32	271-274	interleukin 1 alpha	Homo sapiens	5-15
1610549-1	1992	This experiment was conducted in order to investigate whether expression of gangliosides on islet cell surface in vitro is influenced by cytokines, especially interleukin 1.	Gangliosides	76-88	interleukin 1 alpha	Homo sapiens	159-172
1596698-1	1992	Recombinant interleukin-1 (IL-1) alpha and beta stimulated significant loss of glycosaminoglcan (GAG) content from normal (non-arthritic) articular cartilage explants but only after incubation for 14 days and only in specimens from 8/21 (38%) individuals.	glycosaminoglcan	79-95	interleukin 1 alpha	Homo sapiens	12-25
1596698-1	1992	Recombinant interleukin-1 (IL-1) alpha and beta stimulated significant loss of glycosaminoglcan (GAG) content from normal (non-arthritic) articular cartilage explants but only after incubation for 14 days and only in specimens from 8/21 (38%) individuals.	glycosaminoglcan	79-95	interleukin 1 alpha	Homo sapiens	27-38
1596698-1	1992	Recombinant interleukin-1 (IL-1) alpha and beta stimulated significant loss of glycosaminoglcan (GAG) content from normal (non-arthritic) articular cartilage explants but only after incubation for 14 days and only in specimens from 8/21 (38%) individuals.	Glycosaminoglycans	97-100	interleukin 1 alpha	Homo sapiens	12-25
1596698-1	1992	Recombinant interleukin-1 (IL-1) alpha and beta stimulated significant loss of glycosaminoglcan (GAG) content from normal (non-arthritic) articular cartilage explants but only after incubation for 14 days and only in specimens from 8/21 (38%) individuals.	Glycosaminoglycans	97-100	interleukin 1 alpha	Homo sapiens	27-38
1596698-3	1992	The reduction in GAG induced by IL-1 was also greater for both OA and RA cartilage than normal cartilage.	Glycosaminoglycans	17-20	interleukin 1 alpha	Homo sapiens	32-36
1511500-5	1992	Thus, the inflammatory cytokines IL-1 and TNF alpha reportedly detected in the circulation during severe sepsis may directly affect not only glucose uptake but also its subsequent metabolism within tissue fibroblasts.	Glucose	141-148	interleukin 1 alpha	Homo sapiens	33-37
1425452-3	1992	IL-1 by itself enhanced [3H]thymidine incorporation in a concentration-dependent manner.	Tritium	25-27	interleukin 1 alpha	Homo sapiens	0-4
1425452-3	1992	IL-1 by itself enhanced [3H]thymidine incorporation in a concentration-dependent manner.	Thymidine	28-37	interleukin 1 alpha	Homo sapiens	0-4
1425452-7	1992	When IL-1 and TNF alpha were added together in relatively low concentrations (1 ng/ml each), the combination had synergistic effects in enhancing [3H]thymidine incorporation.	Tritium	147-149	interleukin 1 alpha	Homo sapiens	5-9
1425452-4	1992	Moreover, IL-1 acted synergistically with insulin, epidermal growth factor (EGF), or fibroblast growth factor (FGF) to enhance [3H]thymidine incorporation.	Tritium	128-130	interleukin 1 alpha	Homo sapiens	10-14
1425452-7	1992	When IL-1 and TNF alpha were added together in relatively low concentrations (1 ng/ml each), the combination had synergistic effects in enhancing [3H]thymidine incorporation.	Thymidine	150-159	interleukin 1 alpha	Homo sapiens	5-9
1425452-4	1992	Moreover, IL-1 acted synergistically with insulin, epidermal growth factor (EGF), or fibroblast growth factor (FGF) to enhance [3H]thymidine incorporation.	Thymidine	131-140	interleukin 1 alpha	Homo sapiens	10-14
1376256-0	1992	Interleukin-1 induces protein tyrosine phosphorylation in T cells.	Tyrosine	30-38	interleukin 1 alpha	Homo sapiens	0-13
1376256-7	1992	Independent of cAMP, by tyrosine phosphorylation of specific substrates IL-1 also induces c-myc and IL-6 mRNA expression and cellular proliferation.	Tyrosine	24-32	interleukin 1 alpha	Homo sapiens	72-76
1376256-2	1992	In the present report we show that IL-1 induces the activation of tyrosine kinase in these cells, leading to tyrosine phosphorylation of a subset of proteins of 38, 75, 97 and 115 kDa.	Tyrosine	66-74	interleukin 1 alpha	Homo sapiens	35-39
1376256-6	1992	Altogether, our results demonstrate that the activation of a tyrosine kinase(s) is an early and major event that happens after IL-1/IL-1R interaction, leading to an increase in intracellular cAMP which results in c-myb and IL-5 mRNA expression.	Cyclic AMP	191-195	interleukin 1 alpha	Homo sapiens	127-131
1528578-6	1992	As the result, it is considered that M phi in the peritoneal cavity secrete IL-1, which has no influence on ovulation, but inhibits cleavage of the fertilized ovum, decreases the content of intracellular glycogen in the endometrium, and disturbs the environment for ovular growth after implantation, resulting in infertility.	Glycogen	204-212	interleukin 1 alpha	Homo sapiens	76-80
1587305-1	1992	The ability of highly purified, recombinant human macrophage colony-stimulating factor (M-CSF) and recombinant human interleukin 1 alpha (IL-1) to rescue hematopoietic activity from the myelosuppressive effects of 5-fluorouracil (5-FU) was investigated in the C57Bl/6 mouse.	Fluorouracil	214-228	interleukin 1 alpha	Homo sapiens	138-142
1587305-1	1992	The ability of highly purified, recombinant human macrophage colony-stimulating factor (M-CSF) and recombinant human interleukin 1 alpha (IL-1) to rescue hematopoietic activity from the myelosuppressive effects of 5-fluorouracil (5-FU) was investigated in the C57Bl/6 mouse.	Fluorouracil	230-234	interleukin 1 alpha	Homo sapiens	138-142
1587305-2	1992	IL-1 (q24 h x 4) stimulated granulopoietic recovery in the 5-FU-treated animals and reduced the period of severe neutropenia associated with this drug by 7 days.	Fluorouracil	59-63	interleukin 1 alpha	Homo sapiens	0-4
1587305-5	1992	Unexpectedly, the combination of IL-1 plus M-CSF (q24 h, days 1-4) followed by M-CSF (q24 h, days 5-14) resulted in a more than additive stimulation of progenitor recovery in both the marrow and the spleen that was observed as early as day 3 following 5-FU treatment.	Fluorouracil	252-256	interleukin 1 alpha	Homo sapiens	33-37
1587305-6	1992	Furthermore, in the absence of protracted M-CSF administration on days 5-14, the 4-day rescue with a combination of IL-1 plus M-CSF also resulted in a more than additive effect on the recovery from 5-FU-induced neutropenia.	Fluorouracil	198-202	interleukin 1 alpha	Homo sapiens	116-120
1587305-7	1992	Collectively, these observations demonstrated that IL-1 and M-CSF can interact synergistically to stimulate granulopoietic recovery in the 5-FU-treated animal.	Fluorouracil	139-143	interleukin 1 alpha	Homo sapiens	51-55
1319454-8	1992	The effect of IL-1 took 2 h to develop and was blocked by cycloheximide (100 mumol/l).	Cycloheximide	58-71	interleukin 1 alpha	Homo sapiens	14-18
1319454-10	1992	Many of the actions of IL-1 are mediated by prostaglandin E2 (PGE2).	Dinoprostone	44-60	interleukin 1 alpha	Homo sapiens	23-27
1319454-10	1992	Many of the actions of IL-1 are mediated by prostaglandin E2 (PGE2).	Dinoprostone	62-66	interleukin 1 alpha	Homo sapiens	23-27
1630586-2	1992	Since metabolites of the arachidonic acid cascade (AAC) have been implicated in mediating actions of cytokines in different tissues and some AAC inhibitors were able to block pyrogenic effects of cytokines and suppress IL-1-induced ACTH secretion, we decided to examine the mechanism of IL-6 action on CRF release in vitro.	Arachidonic Acid	25-41	interleukin 1 alpha	Homo sapiens	219-223
1587265-1	1992	Stimulation of human monocytes by lipopolysaccharide or phorbol ester resulted in an increase in thromboxane-B2 and prostaglandin-E2 production, whereas interleukin 1, tumour necrosis factor alpha and leukotriene C4 exerted no effects.	Phorbol Esters	56-69	interleukin 1 alpha	Homo sapiens	153-196
1315505-4	1992	Similarly, IL-1-induced CSF-1 production was inhibited by cholera toxin and this inhibition was reversed by an arginine analog, p-methoxy-benzylaminodecamethylene guanidine sulfate.	Arginine	111-119	interleukin 1 alpha	Homo sapiens	11-15
1315505-4	1992	Similarly, IL-1-induced CSF-1 production was inhibited by cholera toxin and this inhibition was reversed by an arginine analog, p-methoxy-benzylaminodecamethylene guanidine sulfate.	p-methoxy-benzylaminodecamethylene guanidine sulfate	128-180	interleukin 1 alpha	Homo sapiens	11-15
1315505-5	1992	Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1.	Bucladesine	0-14	interleukin 1 alpha	Homo sapiens	105-109
1315505-5	1992	Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1.	Cyclic AMP	10-14	interleukin 1 alpha	Homo sapiens	105-109
1315505-5	1992	Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1.	Theophylline	62-74	interleukin 1 alpha	Homo sapiens	105-109
1315505-5	1992	Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1.	Colforsin	79-88	interleukin 1 alpha	Homo sapiens	105-109
1315505-5	1992	Dibutyryl-cAMP as well as other cAMP elevating agents such as theophylline and forskolin also suppressed IL-1-induced CSF-1 production, suggesting that cAMP concentrations inversely regulate the biosynthesis of CSF-1.	Cyclic AMP	32-36	interleukin 1 alpha	Homo sapiens	105-109
1315505-6	1992	Measurement of cAMP concentration indicated that IL-1 treatment of MIA PaCa-2 cells did not change the cAMP level.	Cyclic AMP	15-19	interleukin 1 alpha	Homo sapiens	49-53
1315505-7	1992	IL-1-induced CSF-1 production was not suppressed by the protein kinase C (PKC) inhibitor, H7, under conditions in which 12-O-tetradecanoylphorbol-13-acetate-induced CSF-1 production was completely abolished.	Tetradecanoylphorbol Acetate	120-156	interleukin 1 alpha	Homo sapiens	0-4
1584804-8	1992	IL-1 mRNA accumulates in young fibroblasts treated with cycloheximide, suggesting that it is transcribed but unstable in these cells; accumulation of IL-1 mRNA in old fibroblasts may be due at least in part to increased stability.	Cycloheximide	56-69	interleukin 1 alpha	Homo sapiens	0-4
1510423-0	1992	Pharmacologic modulation of interleukin-1 expression by amphotericin B-stimulated human mononuclear cells.	Amphotericin B	56-70	interleukin 1 alpha	Homo sapiens	28-41
1414690-1	1992	Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage.	Bleomycin	97-106	interleukin 1 alpha	Homo sapiens	15-19
1414690-1	1992	Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage.	Silicon Dioxide	112-118	interleukin 1 alpha	Homo sapiens	15-19
1414690-2	1992	We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin.	Paraquat	30-38	interleukin 1 alpha	Homo sapiens	77-81
1414690-2	1992	We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin.	Paraquat	40-42	interleukin 1 alpha	Homo sapiens	77-81
1414690-3	1992	PQ (100 microM) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold).	Paraquat	0-2	interleukin 1 alpha	Homo sapiens	28-32
1414690-4	1992	It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.	Paraquat	92-94	interleukin 1 alpha	Homo sapiens	32-36
1397536-0	1992	Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production.	Staurosporine	10-23	interleukin 1 alpha	Homo sapiens	39-43
1616390-4	1992	Uptake of 50 microM glutamine was determined after a 12-hour incubation with varying doses (10 to 1000 U/mL) of tumor necrosis factor-alpha, interleukin-1, interleukin-6, interferon-gamma, and various combinations of these cytokines.	Glutamine	20-29	interleukin 1 alpha	Homo sapiens	141-154
1397536-0	1992	Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production.	Prostaglandins E	55-70	interleukin 1 alpha	Homo sapiens	39-43
1533322-12	1992	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a band at 85 Kd corresponding to the 68-Kd IL-1 receptor type II (IL-1RtII).	Sodium Dodecyl Sulfate	0-22	interleukin 1 alpha	Homo sapiens	108-112
1533322-12	1992	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a band at 85 Kd corresponding to the 68-Kd IL-1 receptor type II (IL-1RtII).	polyacrylamide	23-37	interleukin 1 alpha	Homo sapiens	108-112
1498252-11	1992	In contrast, the addition of the stimulatory agent IL-1 alpha to hydrocortisone-treated cells resulted in no increase in IL-1 beta mRNA.	Hydrocortisone	65-79	interleukin 1 alpha	Homo sapiens	51-61
1315688-0	1992	Interleukin-1 up-regulates transcription of its own receptor in a human fibroblast cell line TIG-1: role of endogenous PGE2 and cAMP.	Dinoprostone	119-123	interleukin 1 alpha	Homo sapiens	0-13
1315688-0	1992	Interleukin-1 up-regulates transcription of its own receptor in a human fibroblast cell line TIG-1: role of endogenous PGE2 and cAMP.	Cyclic AMP	128-132	interleukin 1 alpha	Homo sapiens	0-13
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	217-233	interleukin 1 alpha	Homo sapiens	48-58
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	235-239	interleukin 1 alpha	Homo sapiens	48-58
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Cyclic AMP	255-259	interleukin 1 alpha	Homo sapiens	48-58
1602241-0	1992	Stimulation of human monocyte and polymorphonuclear cell iodination and interleukin-1 production by epigallocatechin gallate.	epigallocatechin gallate	100-124	interleukin 1 alpha	Homo sapiens	72-85
1582808-5	1992	Of the various compounds examined, only interleukin-1 (IL-1) and transforming growth factor (TGF)-beta significantly stimulated [3H]GAG accumulation in a dose- and time-dependent fashion.	Tritium	129-131	interleukin 1 alpha	Homo sapiens	40-53
1582808-5	1992	Of the various compounds examined, only interleukin-1 (IL-1) and transforming growth factor (TGF)-beta significantly stimulated [3H]GAG accumulation in a dose- and time-dependent fashion.	Tritium	129-131	interleukin 1 alpha	Homo sapiens	55-59
1582808-5	1992	Of the various compounds examined, only interleukin-1 (IL-1) and transforming growth factor (TGF)-beta significantly stimulated [3H]GAG accumulation in a dose- and time-dependent fashion.	Glycosaminoglycans	132-135	interleukin 1 alpha	Homo sapiens	40-53
1582808-5	1992	Of the various compounds examined, only interleukin-1 (IL-1) and transforming growth factor (TGF)-beta significantly stimulated [3H]GAG accumulation in a dose- and time-dependent fashion.	Glycosaminoglycans	132-135	interleukin 1 alpha	Homo sapiens	55-59
1582808-7	1992	In conclusion, both IL-1 and TGF-beta are potent stimulators of [3H]GAG accumulation by retroocular connective tissue and perimysial fibroblasts, as well as by fibroblasts from the dermal sites studied.	Tritium	65-67	interleukin 1 alpha	Homo sapiens	20-24
1582808-7	1992	In conclusion, both IL-1 and TGF-beta are potent stimulators of [3H]GAG accumulation by retroocular connective tissue and perimysial fibroblasts, as well as by fibroblasts from the dermal sites studied.	Glycosaminoglycans	68-71	interleukin 1 alpha	Homo sapiens	20-24
1573267-7	1992	Thioglycollate-elicited peritoneal exudate macrophages incubated with native doublet MIP 1-secreted bioactive TNF and IL-6, as well as immunoreactive IL-1 alpha, and these effects were enhanced significantly when the cells were costimulated with IFN-gamma.	Thioglycolates	0-14	interleukin 1 alpha	Homo sapiens	150-160
1602241-5	1992	EGCg also potently stimulated the production of interleukin-1-like factor by monocytes.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	48-61
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	142-155
1619908-0	1992	Kupffer cell autoregulation of IL-1 production by PGE2 during hepatic regeneration.	Dinoprostone	50-54	interleukin 1 alpha	Homo sapiens	31-35
1619908-3	1992	Regenerating liver KC 48-120 hr following PHx responded to LPS with a significantly greater (p less than 0.05) production of IL-1 in standard RPMI-1640.	rpmi-1640	142-151	interleukin 1 alpha	Homo sapiens	125-129
1619908-4	1992	When 10 microM L-arginine RPMI-1640 was used to simulate the high arginase activity low L-arginine levels of the hepatic microenvironment, regenerating liver KC production of IL-1 was further increased (p less than 0.05).	Arginine	15-25	interleukin 1 alpha	Homo sapiens	175-179
1619908-4	1992	When 10 microM L-arginine RPMI-1640 was used to simulate the high arginase activity low L-arginine levels of the hepatic microenvironment, regenerating liver KC production of IL-1 was further increased (p less than 0.05).	rpmi-1640	26-35	interleukin 1 alpha	Homo sapiens	175-179
1619908-4	1992	When 10 microM L-arginine RPMI-1640 was used to simulate the high arginase activity low L-arginine levels of the hepatic microenvironment, regenerating liver KC production of IL-1 was further increased (p less than 0.05).	Arginine	88-98	interleukin 1 alpha	Homo sapiens	175-179
1619908-6	1992	When the cyclooxygenase inhibitor indomethacin (10 microM) was added to low arginine cultures, the PGE2 production was inhibited, and IL-1 production was upregulated (p less than 0.05).	Indomethacin	34-46	interleukin 1 alpha	Homo sapiens	134-138
1619908-7	1992	We conclude that during hepatic regeneration KC IL-1 production is elevated but controlled in an autoregulatory fashion by KC PGE2 production.	Dinoprostone	126-130	interleukin 1 alpha	Homo sapiens	48-52
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	157-168
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	157-161
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	18-22	interleukin 1 alpha	Homo sapiens	142-155
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	18-22	interleukin 1 alpha	Homo sapiens	157-168
1317213-0	1992	Inhibition of interferon-gamma- and phorbol ester-induced HLA-DR and interleukin-1 production by the expression of a transfected poly(ADP-ribose) synthetase gene in human leukemia THP-1 cells.	Phorbol Esters	36-49	interleukin 1 alpha	Homo sapiens	69-82
1620968-1	1992	Prostaglandin E2 (PGE2) and stromelysin are produced by equine chondrocytes and synovial cells in vitro in response to recombinant human (rh) interleukin-1 (IL-1) alpha and beta, and equine mononuclear cell supernatants (MCS) containing IL-1.	Dinoprostone	18-22	interleukin 1 alpha	Homo sapiens	157-161
1620968-4	1992	Equine MCS, containing a lower concentration of IL-1 than the concentration of rhIL-1 used in these experiments, stimulated production of much higher levels of PGE2 than rhIL-1.	mcs	7-10	interleukin 1 alpha	Homo sapiens	48-52
1620968-4	1992	Equine MCS, containing a lower concentration of IL-1 than the concentration of rhIL-1 used in these experiments, stimulated production of much higher levels of PGE2 than rhIL-1.	Dinoprostone	160-164	interleukin 1 alpha	Homo sapiens	48-52
1636747-6	1992	IL-1-induced COX mass was maintained at an increased level for at least 48 h. The glucocorticoid dexamethasone (DEX) virtually abolished prostaglandin production and blocked cytokine induction of COX activity and mass.	Prostaglandins	137-150	interleukin 1 alpha	Homo sapiens	0-4
1636747-8	1992	By utilizing stable isotope methods, we could demonstrate that IL-1 increased free arachidonate levels, implying new PLA2 synthesis over a time course that was maximal at 6 h and was cycloheximide and actinomycin D sensitive.	Arachidonic Acid	83-95	interleukin 1 alpha	Homo sapiens	63-67
1636747-8	1992	By utilizing stable isotope methods, we could demonstrate that IL-1 increased free arachidonate levels, implying new PLA2 synthesis over a time course that was maximal at 6 h and was cycloheximide and actinomycin D sensitive.	Cycloheximide	183-196	interleukin 1 alpha	Homo sapiens	63-67
1317213-4	1992	When THP-1 cells were treated with either interferon-gamma or phorbol ester, mRNA level of the synthetase decreased and HLA-DR or interleukin-1 was induced, respectively.	Phorbol Esters	62-75	interleukin 1 alpha	Homo sapiens	130-143
1636747-8	1992	By utilizing stable isotope methods, we could demonstrate that IL-1 increased free arachidonate levels, implying new PLA2 synthesis over a time course that was maximal at 6 h and was cycloheximide and actinomycin D sensitive.	Dactinomycin	201-214	interleukin 1 alpha	Homo sapiens	63-67
1636747-9	1992	These data demonstrate that the cytokines IL-1 and TNF enhance synthesis of COX and PLA2, contributing to increased prostaglandin production.	Prostaglandins	116-129	interleukin 1 alpha	Homo sapiens	42-46
1317213-6	1992	An expression of the exogenous synthetase gene inhibited the interferon-gamma- and phorbol ester-dependent induction of HLA-DR and interleukin-1.	Phorbol Esters	83-96	interleukin 1 alpha	Homo sapiens	131-144
1636747-11	1992	This occurs because DEX inhibits the IL-1-induced enhanced arachidonate release.	Dexamethasone	20-23	interleukin 1 alpha	Homo sapiens	37-41
1516641-0	1992	Interleukin-1 alpha-stimulated fibroblast eicosanoid synthesis is not mediated by interleukin-6.	Eicosanoids	42-52	interleukin 1 alpha	Homo sapiens	0-19
1636747-11	1992	This occurs because DEX inhibits the IL-1-induced enhanced arachidonate release.	Arachidonic Acid	59-71	interleukin 1 alpha	Homo sapiens	37-41
1591276-3	1992	However, BK stimulated the production of prostaglandin E2, an effect that was markedly enhanced by pre-incubation with recombinant interleukin-1 alpha (rhIL-1 alpha), but was apparently unaffected by BK receptor antagonists types 1 and 2.	Dinoprostone	41-57	interleukin 1 alpha	Homo sapiens	131-150
1516641-2	1992	Although human dermal fibroblasts did not secrete interleukin-1 alpha or interleukin-1 beta, human recombinant interleukin-1 alpha stimulated arachidonic acid metabolism and interleukin-6 synthesis.	Arachidonic Acid	142-158	interleukin 1 alpha	Homo sapiens	111-130
1516641-5	1992	Human recombinant interleukin-1 alpha also stimulated the metabolism of [14C]arachidonic acid, but only if fibroblast were pre-incubated with the cytokine for three hours.	[14c]arachidonic acid	72-93	interleukin 1 alpha	Homo sapiens	18-37
1516641-6	1992	Our data indicate that (a) fibroblasts secrete interleukin-6 but not interleukin-1, (b) interleukin-1 alpha, but not interleukin-6, stimulates fibroblast arachidonic acid metabolism and (c) the mechanisms involved in the metabolism of endogenous arachidonic acid are more sensitive to human recombinant interleukin-1 alpha than those involved in metabolism of the exogenous substrate.	Arachidonic Acid	154-170	interleukin 1 alpha	Homo sapiens	88-107
1516641-6	1992	Our data indicate that (a) fibroblasts secrete interleukin-6 but not interleukin-1, (b) interleukin-1 alpha, but not interleukin-6, stimulates fibroblast arachidonic acid metabolism and (c) the mechanisms involved in the metabolism of endogenous arachidonic acid are more sensitive to human recombinant interleukin-1 alpha than those involved in metabolism of the exogenous substrate.	Arachidonic Acid	246-262	interleukin 1 alpha	Homo sapiens	88-107
1373107-7	1992	Pretreatment of endothelial cells with IL-1 increased their adhesion to fibronectin and vitronectin and increased the expression of vitronectin receptor and fibronectin receptor as detected by immunofluorescence flow cytometry, quantitative antibody binding, and immunoprecipitation of [35S]methionine-labeled cell extracts.	Sulfur-35	287-290	interleukin 1 alpha	Homo sapiens	39-43
1372239-0	1992	Interleukin-1 alpha and tumor necrosis factor-alpha differentially regulate enkephalin, vasoactive intestinal polypeptide, neurotensin, and substance P biosynthesis in chromaffin cells.	chromaffin	168-178	interleukin 1 alpha	Homo sapiens	0-19
1373107-7	1992	Pretreatment of endothelial cells with IL-1 increased their adhesion to fibronectin and vitronectin and increased the expression of vitronectin receptor and fibronectin receptor as detected by immunofluorescence flow cytometry, quantitative antibody binding, and immunoprecipitation of [35S]methionine-labeled cell extracts.	Methionine	291-301	interleukin 1 alpha	Homo sapiens	39-43
1558854-4	1992	The IL-1 receptor antagonist protein (IRAP) eliminated chondrocyte activation by IL-1, but only partially inhibited activation by CAF.	cafestol palmitate	130-133	interleukin 1 alpha	Homo sapiens	4-8
1558854-5	1992	Thus, CAF may contain a cytokine in addition to IL-1 which activates chondrocytes.	cafestol palmitate	6-9	interleukin 1 alpha	Homo sapiens	48-52
1554223-5	1992	Paraformaldehyde-fixed bronchoalveolar lavage cells from RSV-infected but not uninfected patients induced a marked proliferative response by cloned T cells indicating that in vivo infected cells expressed bioactive interleukin-1.	paraform	0-16	interleukin 1 alpha	Homo sapiens	215-228
1372239-3	1992	Stimulation of VIP and substance P biosynthesis by forskolin was markedly enhanced by IL-1 alpha, while forskolin stimulation of enkephalin and neurotensin biosynthesis was unaffected.	Colforsin	51-60	interleukin 1 alpha	Homo sapiens	86-96
1372239-4	1992	IL-1 alpha amplified the effect of phorbol myristate acetate to increase the VIP content of chromaffin cells, but antagonized phorbol ester-induced elevation of neurotensin levels.	Tetradecanoylphorbol Acetate	35-60	interleukin 1 alpha	Homo sapiens	0-10
1372239-4	1992	IL-1 alpha amplified the effect of phorbol myristate acetate to increase the VIP content of chromaffin cells, but antagonized phorbol ester-induced elevation of neurotensin levels.	chromaffin	92-102	interleukin 1 alpha	Homo sapiens	0-10
1372239-4	1992	IL-1 alpha amplified the effect of phorbol myristate acetate to increase the VIP content of chromaffin cells, but antagonized phorbol ester-induced elevation of neurotensin levels.	Phorbol Esters	126-139	interleukin 1 alpha	Homo sapiens	0-10
1372239-8	1992	These data provide a functional demonstration of IL-1 and TNF receptors in chromaffin cell cultures and suggest a physiological role for cytokine production in the adrenal medulla.	chromaffin	75-85	interleukin 1 alpha	Homo sapiens	49-53
1522186-0	1992	The correlation of interleukin 1 and tumour necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicular fluid of in-vitro fertilization patients.	Estradiol	63-73	interleukin 1 alpha	Homo sapiens	19-59
1348040-3	1992	IL-1 alpha and IL-1 beta dose-dependently (1-10 micrograms/kg) reduced the severity of gastric damage induced by indomethacin, whereas tumor necrosis factor alpha (1-10 micrograms/kg) had no effect.	Indomethacin	113-125	interleukin 1 alpha	Homo sapiens	0-10
1348040-5	1992	Whereas IL-1 alpha and IL-1 beta significantly inhibited pentagastrin-stimulated acid secretion, the dose-response relationship and time course of actions suggested that effects on acid secretion did not fully account for the ability of these agents to reduce indomethacin-induced gastric injury.	Pentagastrin	57-69	interleukin 1 alpha	Homo sapiens	8-18
1522186-0	1992	The correlation of interleukin 1 and tumour necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicular fluid of in-vitro fertilization patients.	Progesterone	75-87	interleukin 1 alpha	Homo sapiens	19-59
1522186-0	1992	The correlation of interleukin 1 and tumour necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicular fluid of in-vitro fertilization patients.	Testosterone	92-104	interleukin 1 alpha	Homo sapiens	19-59
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Estradiol	174-184	interleukin 1 alpha	Homo sapiens	77-90
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Estradiol	174-184	interleukin 1 alpha	Homo sapiens	92-96
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Progesterone	186-198	interleukin 1 alpha	Homo sapiens	77-90
1592440-2	1992	Over a wide dose range, dexamethasone inhibited IL-8 production induced by IL-1 alpha stimulation.	Dexamethasone	24-37	interleukin 1 alpha	Homo sapiens	75-85
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Progesterone	186-198	interleukin 1 alpha	Homo sapiens	92-96
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Testosterone	203-215	interleukin 1 alpha	Homo sapiens	77-90
1522186-2	1992	The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels.	Testosterone	203-215	interleukin 1 alpha	Homo sapiens	92-96
1522186-6	1992	There was a significant (P less than 0.01) positive correlation between IL-1 and progesterone levels.	Progesterone	81-93	interleukin 1 alpha	Homo sapiens	72-76
1593570-3	1992	MC isolated from inflammatory SF produced, in addition to variable levels of IL-1, a specific IL-1 inhibitor of approximately 23 kDa which blocked both IL-1 biological activity and binding to its receptor.	Methylcholanthrene	0-2	interleukin 1 alpha	Homo sapiens	77-81
1548425-3	1992	In the present study, we investigated the effects of tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), IL-4, and transforming growth factor-beta 1 (TGF-beta) on the adhesiveness of DMEC isolated from psoriatic plaques or normal skin for human peripheral blood mononuclear cells (PBMC).	dmec	188-192	interleukin 1 alpha	Homo sapiens	88-101
1548425-3	1992	In the present study, we investigated the effects of tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), IL-4, and transforming growth factor-beta 1 (TGF-beta) on the adhesiveness of DMEC isolated from psoriatic plaques or normal skin for human peripheral blood mononuclear cells (PBMC).	dmec	188-192	interleukin 1 alpha	Homo sapiens	103-107
1548425-5	1992	Pretreatment of DMEC from normal skin with human recombinant IL-1 or TNF alone or in combination for 8 h significantly (p less than 0.01) enhanced their capacity to adhere to human PBMC.	dmec	16-20	interleukin 1 alpha	Homo sapiens	61-65
1548425-6	1992	Similarly, treatment of normal DMEC with IL-4 also increased endothelial adhesiveness, although this cytokine required an incubation period of 24 h. In parallel studies, DMEC from psoriatic plaques were found to respond to the stimulatory effects of TNF, IL-1, and IL-4 in similar dose- and time-dependent manner.	dmec	170-174	interleukin 1 alpha	Homo sapiens	255-259
1600120-9	1992	Dialysis induced an active synthesis of IL-1 by peripheral blood mononuclear cells, even in the absence of sodium acetate in the dialysate bath, but there was no release of IL-1 to the circulating medium.	Sodium Acetate	107-121	interleukin 1 alpha	Homo sapiens	40-44
1593570-3	1992	MC isolated from inflammatory SF produced, in addition to variable levels of IL-1, a specific IL-1 inhibitor of approximately 23 kDa which blocked both IL-1 biological activity and binding to its receptor.	Methylcholanthrene	0-2	interleukin 1 alpha	Homo sapiens	94-98
1593570-3	1992	MC isolated from inflammatory SF produced, in addition to variable levels of IL-1, a specific IL-1 inhibitor of approximately 23 kDa which blocked both IL-1 biological activity and binding to its receptor.	Methylcholanthrene	0-2	interleukin 1 alpha	Homo sapiens	94-98
1586876-4	1992	PBM obtained during severe asthma showed a pattern of IL-1 and TNF secretion similar to that of normal subjects.	pbm	0-3	interleukin 1 alpha	Homo sapiens	54-58
1312061-4	1992	[35S]-labelled single-stranded RNA probes were prepared by transcribing human cDNA fragments of the TNF-alpha and IL-1 alpha genes subcloned into appropriate vectors.	Sulfur-35	1-4	interleukin 1 alpha	Homo sapiens	114-124
1545152-3	1992	After 6-h treatment with the phorbol ester PMA, gene expression for IL-1 alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, and the IL-6 receptor were increased.	Phorbol Esters	29-42	interleukin 1 alpha	Homo sapiens	68-78
1617996-10	1992	New agents such as WR2721, IL-3, and IL-1 alpha are undergoing clinical evaluation to determine whether the toxicities of platinum compounds can be decreased and lead to further exploitation of the dose response relationship.	Platinum	122-130	interleukin 1 alpha	Homo sapiens	37-47
1371258-1	1992	OBJECTIVE: To investigate the expression of interleukin-1 (IL-1) beta messenger ribonucleic acid (mRNA) and IL-1 receptor antagonist (IL-1ra) mRNA in peritoneal macrophages.	ribonucleic	80-91	interleukin 1 alpha	Homo sapiens	44-57
1371258-1	1992	OBJECTIVE: To investigate the expression of interleukin-1 (IL-1) beta messenger ribonucleic acid (mRNA) and IL-1 receptor antagonist (IL-1ra) mRNA in peritoneal macrophages.	ribonucleic	80-91	interleukin 1 alpha	Homo sapiens	59-63
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	115-125
1498519-8	1992	Further, our data demonstrate that tumor necrosis factor and IL-1 play an important role in the up-regulation of LAK activity by monocytes that have been pretreated with FK-565 or CP.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	170-176	interleukin 1 alpha	Homo sapiens	61-65
1541678-1	1992	An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents.	Nitric Oxide	106-118	interleukin 1 alpha	Homo sapiens	48-61
1541678-1	1992	An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents.	Arginine	129-139	interleukin 1 alpha	Homo sapiens	48-61
1374829-8	1992	In the presence of IB4, adhesion of PMNs to untreated and IL-1-pretreated type 3 and 4 endothelial cells was significantly reduced by PMA.	ib4	19-22	interleukin 1 alpha	Homo sapiens	58-62
1571831-7	1992	These results suggest that the cytokines, IL-1 and TNF-beta, can increase t-PA activity in G292 cells and that there is both a cAMP-dependent as well as a cAMP-independent pathway involved in the regulation of this osteoblastic cell function.	Cyclic AMP	155-159	interleukin 1 alpha	Homo sapiens	42-46
1550404-10	1992	In contrast, dexamethasone (10(-6) mol/l) suppressed the ability of IL-1 to increase the expression of IL-6 mRNA.	Dexamethasone	13-26	interleukin 1 alpha	Homo sapiens	68-72
1561701-0	1992	Modulation of interleukin-1 induced thymocyte proliferation by D-mannose.	Mannose	63-72	interleukin 1 alpha	Homo sapiens	14-27
1561701-2	1992	The monosaccharide, D-mannose (4-10 mM), significantly inhibited thymocyte proliferation induced by recombinant interleukin-1 (rIL-1).	Monosaccharides	4-18	interleukin 1 alpha	Homo sapiens	112-125
1561701-2	1992	The monosaccharide, D-mannose (4-10 mM), significantly inhibited thymocyte proliferation induced by recombinant interleukin-1 (rIL-1).	Mannose	20-29	interleukin 1 alpha	Homo sapiens	112-125
1561701-3	1992	Mannose also inhibited the proliferation response to native, human IL-1.	Mannose	0-7	interleukin 1 alpha	Homo sapiens	67-71
1571831-4	1992	The effect of IL-1 at 10.0 U/ml was partially inhibited in the presence of indomethacin.	Indomethacin	75-87	interleukin 1 alpha	Homo sapiens	14-18
1639431-0	1992	Increased release of interleukin-1 and tumour necrosis factor by interleukin-2-induced lymphokine-activated killer cells in the presence of cisplatin and FK-565.	Cisplatin	140-149	interleukin 1 alpha	Homo sapiens	21-61
1571831-5	1992	Forskolin (1.0 microM) increased t-PA activity after 24 hours with the effects of combined treatment of IL-1 (1.0 U/ml, 10.0 U/ml) and forskolin being apparently additive in nature.	Colforsin	0-9	interleukin 1 alpha	Homo sapiens	104-108
1571831-7	1992	These results suggest that the cytokines, IL-1 and TNF-beta, can increase t-PA activity in G292 cells and that there is both a cAMP-dependent as well as a cAMP-independent pathway involved in the regulation of this osteoblastic cell function.	Cyclic AMP	127-131	interleukin 1 alpha	Homo sapiens	42-46
1729138-0	1992	Culture of human dermal fibroblasts in collagen gels: modulation of interleukin 1-induced prostaglandin E2 synthesis by an extracellular matrix.	Dinoprostone	90-106	interleukin 1 alpha	Homo sapiens	68-81
1729138-7	1992	These results are consistent with interleukin 1 (IL 1) stimulating PGE2 synthesis in dermal fibroblasts by increasing cyclooxygenase activity.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	34-53
1729138-8	1992	Furthermore, the results show that dermal fibroblasts have an additional regulatory mechanism, related to the cell population densities or their interactions with an extracellular matrix, to finely modulate the amount of PGE2 synthesized in response to IL 1.	Dinoprostone	221-225	interleukin 1 alpha	Homo sapiens	253-257
1532379-1	1992	Pretreatment of epidermal cells (EC) with hydrocortisone or dexamethasone abolishes their capacity to produce interleukin-1 (IL-1) and therefore reduces their capacity to support proliferative response of lectin-stimulated T cells.	Hydrocortisone	42-56	interleukin 1 alpha	Homo sapiens	125-129
1532379-1	1992	Pretreatment of epidermal cells (EC) with hydrocortisone or dexamethasone abolishes their capacity to produce interleukin-1 (IL-1) and therefore reduces their capacity to support proliferative response of lectin-stimulated T cells.	Dexamethasone	60-73	interleukin 1 alpha	Homo sapiens	125-129
1639431-0	1992	Increased release of interleukin-1 and tumour necrosis factor by interleukin-2-induced lymphokine-activated killer cells in the presence of cisplatin and FK-565.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	154-160	interleukin 1 alpha	Homo sapiens	21-61
1370516-9	1992	The protein synthesis inhibitor cycloheximide (Cy) blocked IL-1-, TNF-, or LPS-induced MCP gene expression in monocytes.	Cycloheximide	32-45	interleukin 1 alpha	Homo sapiens	59-63
1370516-9	1992	The protein synthesis inhibitor cycloheximide (Cy) blocked IL-1-, TNF-, or LPS-induced MCP gene expression in monocytes.	Cycloheximide	47-49	interleukin 1 alpha	Homo sapiens	59-63
1371624-0	1992	Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2.	Tacrolimus	31-37	interleukin 1 alpha	Homo sapiens	56-75
19912845-0	1992	Increased sensitivity of glioblastoma cells to interleukin 1 after long-term incubation with dexamethasone.	Dexamethasone	93-106	interleukin 1 alpha	Homo sapiens	47-60
19912845-5	1992	However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6.	Dexamethasone	57-60	interleukin 1 alpha	Homo sapiens	95-99
19912845-7	1992	However, maximum IL 6 production at high doses of IL 1beta was inhibited in cells cultured in the presence of DEX during the IL 1 challenge.	Dexamethasone	110-113	interleukin 1 alpha	Homo sapiens	50-54
19912845-8	1992	Thus, the results suggest the possibility that when glucocorticoids are elevated for extended periods, and concentrations of IL 1 are low because of steroid suppression of IL 1 production, actions of IL 1 may be maintained or even augmented due to up-regulated IL 1 receptor expression in particular cell types.	Steroids	149-156	interleukin 1 alpha	Homo sapiens	125-129
1556000-5	1992	The exposure to ara-C inhibits the proliferation of a higher proportion of clonogenic cells in culture pretreated with IL-3 than in control or cells pretreated with IL-1.	Cytarabine	16-21	interleukin 1 alpha	Homo sapiens	165-169
1313779-6	1992	In contrast, indomethacin had no effect on proteoglycan synthesis and superoxide generation, although it accelerated the IL-1 production.	Indomethacin	13-25	interleukin 1 alpha	Homo sapiens	121-125
1546442-2	1992	Human interleukin-1 beta was about three to ten times as active on equine synovial cells as human interleukin-1 alpha in terms of prostaglandin E2 production.	Dinoprostone	130-146	interleukin 1 alpha	Homo sapiens	98-117
1332453-3	1992	Recently, interleukin-1 receptor antagonist (IL-1ra), a natural inhibitor of IL-1 released by macrophages, has been reported to inhibit PGE2.	Dinoprostone	136-140	interleukin 1 alpha	Homo sapiens	45-49
1370482-0	1992	Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	126-139
1370482-1	1992	Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	91-104
1370482-1	1992	Okadaic acid, a phosphatase inhibitor from a marine organism, mimics tumor necrosis factor/interleukin-1 (TNF/IL-1) in inducing changes in early cellular protein phosphorylation.	Okadaic Acid	0-12	interleukin 1 alpha	Homo sapiens	110-114
1370390-7	1992	Hybridization with 32P-labeled oligonucleotides specific for the respective cytokine messenger RNAs (mRNAs) showed a 10-fold lower prevalence of transcripts for TNF, IL-1, and IL-6, as well.	Phosphorus-32	19-22	interleukin 1 alpha	Homo sapiens	166-170
1370390-7	1992	Hybridization with 32P-labeled oligonucleotides specific for the respective cytokine messenger RNAs (mRNAs) showed a 10-fold lower prevalence of transcripts for TNF, IL-1, and IL-6, as well.	Oligonucleotides	31-47	interleukin 1 alpha	Homo sapiens	166-170
1359744-7	1992	Prednisolone significantly and dose-dependently inhibited interleukin-1 release.	Prednisolone	0-12	interleukin 1 alpha	Homo sapiens	58-71
1334331-3	1992	IL-1 not only upregulates the number of kinin receptors on these cells, but may also upregulate a calcium-dependent process involved in the synthesis of prostaglandins.	Calcium	98-105	interleukin 1 alpha	Homo sapiens	0-4
1354433-0	1992	Study of immune-associated antigens (IL-1 and ICAM-1) in normal human keratinocytes treated by sodium lauryl sulphate.	Sodium Dodecyl Sulfate	95-117	interleukin 1 alpha	Homo sapiens	9-41
1334331-3	1992	IL-1 not only upregulates the number of kinin receptors on these cells, but may also upregulate a calcium-dependent process involved in the synthesis of prostaglandins.	Prostaglandins	153-167	interleukin 1 alpha	Homo sapiens	0-4
1456666-4	1992	This study also confirmed the protective effects of IL-1 in experimental NSAID-gastropathy, and demonstrates that one of the ways the IL-1 may protect the mucosa is through its ability to inhibit the release of proinflammatory mediators (e.g., PAF) and promote the release of antiinflammatory mediators (e.g., nitric oxide).	Platelet Activating Factor	244-247	interleukin 1 alpha	Homo sapiens	134-138
1456666-4	1992	This study also confirmed the protective effects of IL-1 in experimental NSAID-gastropathy, and demonstrates that one of the ways the IL-1 may protect the mucosa is through its ability to inhibit the release of proinflammatory mediators (e.g., PAF) and promote the release of antiinflammatory mediators (e.g., nitric oxide).	Nitric Oxide	310-322	interleukin 1 alpha	Homo sapiens	134-138
1370149-0	1992	Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis.	Prostaglandins	136-149	interleukin 1 alpha	Homo sapiens	73-86
1389011-1	1992	We investigated the capacity of cellulose cuprophane (CUP) and synthetic polyacrylonitrile dialysis membranes to induce the production of interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha using an in vitro model in which normal whole blood is incubated directly with calibrated membrane fragments.	cellulose cuprophane	32-52	interleukin 1 alpha	Homo sapiens	153-157
1389011-1	1992	We investigated the capacity of cellulose cuprophane (CUP) and synthetic polyacrylonitrile dialysis membranes to induce the production of interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha using an in vitro model in which normal whole blood is incubated directly with calibrated membrane fragments.	polyacrylonitrile	73-90	interleukin 1 alpha	Homo sapiens	153-157
1493577-0	1992	[Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)].	Zidovudine	86-100	interleukin 1 alpha	Homo sapiens	40-53
1493577-0	1992	[Demonstration of a protector effect of interleukin-1 against hematologic toxicity of azidothymidine (AZT)].	Zidovudine	102-105	interleukin 1 alpha	Homo sapiens	40-53
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	1-(5-bromo-pyridin-2-yl)-3-[2-(6-fluoro-2-hydroxy-3-propionyl-phenyl)-cyclopropyl]-urea	228-231	interleukin 1 alpha	Homo sapiens	47-66
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	1-(5-bromo-pyridin-2-yl)-3-[2-(6-fluoro-2-hydroxy-3-propionyl-phenyl)-cyclopropyl]-urea	228-231	interleukin 1 alpha	Homo sapiens	68-78
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	Zidovudine	260-263	interleukin 1 alpha	Homo sapiens	47-66
1493577-4	1992	Data reported here show that recombinant human interleukin-1 alpha (IL-1 alpha), a pleiotropic cytokine, was demonstrated to be efficient to protect normal human as well as murine hematopoietic progenitors (CFU-GM, CFU-GEMM and BFU-E) from the toxic effect of AZT.	Zidovudine	260-263	interleukin 1 alpha	Homo sapiens	68-78
1493577-6	1992	The results demonstrate that marrow progenitors respond differently to AZT and point out the potential efficacy of IL-1 alpha to enhance the proliferation of hematopoietic stem cells treated with growth factors (IL-3, erythropoietin) and to minimize the hematopoietic toxicity associated with AZT treatment.	Zidovudine	293-296	interleukin 1 alpha	Homo sapiens	115-125
1628488-4	1992	Treatment with Interleukin-1 (Il-1) or retinol resulted in diminished synthesis and enhanced catabolism of matrix proteoglycans, but the chondrocytes were more sensitive to human recombinant Il-1 alpha than to Il-1 beta.	Vitamin A	39-46	interleukin 1 alpha	Homo sapiens	191-201
1420809-3	1992	We have shown that interleukin-1 and transforming growth factor-beta, cytokines released by the local inflammatory cell infiltrate, are capable of stimulating GAG synthesis by retroocular and pretibial fibroblasts.	Glycosaminoglycans	159-162	interleukin 1 alpha	Homo sapiens	19-68
1622735-3	1992	Monocytes treated with N-CWS at more than 0.5 microgram/ml produced IL-1 and TNF-alpha extracellularly.	n-cws	23-28	interleukin 1 alpha	Homo sapiens	68-72
1576016-0	1992	Effect of calcitriol on the secretion of prostaglandin E2, interleukin 1, and tumor necrosis factor alpha by human monocytes.	Calcitriol	10-20	interleukin 1 alpha	Homo sapiens	41-105
1370149-10	1992	However, indomethacin, a well known inhibitor of prostaglandin synthesis, prevented the increase in lipolysis induced by TNF, IL-1, IFN alpha, IFN beta, or IFN gamma.	Indomethacin	9-21	interleukin 1 alpha	Homo sapiens	126-130
1577097-8	1992	Our data suggest that prostaglandin inhibitors suppress the negative feedback control of myelopoiesis induced by IL-1 and therefore may have a role in augmenting IL-1 stimulation of myelopoiesis.	Prostaglandins	22-35	interleukin 1 alpha	Homo sapiens	113-117
1577097-8	1992	Our data suggest that prostaglandin inhibitors suppress the negative feedback control of myelopoiesis induced by IL-1 and therefore may have a role in augmenting IL-1 stimulation of myelopoiesis.	Prostaglandins	22-35	interleukin 1 alpha	Homo sapiens	162-166
1294622-4	1992	Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes.	Sulbactam	106-115	interleukin 1 alpha	Homo sapiens	172-182
1547025-0	1992	Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A.	Lipid A	140-147	interleukin 1 alpha	Homo sapiens	78-91
1547025-8	1992	Added to PBMo 1 h before LPS it totally inhibited the production of mRNA for TNF and IL-1.	pbmo	9-13	interleukin 1 alpha	Homo sapiens	85-89
1294622-4	1992	Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes.	beta-Lactams	10-22	interleukin 1 alpha	Homo sapiens	172-182
1294622-7	1992	Teicoplanin is a very strong inducer of TNF, IL-1 alpha and IL-6.	Teicoplanin	0-11	interleukin 1 alpha	Homo sapiens	45-55
1294622-4	1992	Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes.	Cephalosporins	48-62	interleukin 1 alpha	Homo sapiens	172-182
1582733-1	1992	The effect of intravenous administration of lentinan, an immunopotentiating polysaccharide, on the production of interleukin 1-alpha (IL 1-alpha), interleukin 1-beta (IL 1-beta) and tumor necrosis factor-alpha (TNF-alpha) by monocytes in peripheral blood mononuclear cells (PBM) was studied in patients with gastric carcinoma.	Lentinan	44-52	interleukin 1 alpha	Homo sapiens	113-132
1294622-4	1992	Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes.	Cefamandole	76-86	interleukin 1 alpha	Homo sapiens	172-182
1294622-4	1992	Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes.	ceftazidin	88-98	interleukin 1 alpha	Homo sapiens	172-182
1582733-1	1992	The effect of intravenous administration of lentinan, an immunopotentiating polysaccharide, on the production of interleukin 1-alpha (IL 1-alpha), interleukin 1-beta (IL 1-beta) and tumor necrosis factor-alpha (TNF-alpha) by monocytes in peripheral blood mononuclear cells (PBM) was studied in patients with gastric carcinoma.	Lentinan	44-52	interleukin 1 alpha	Homo sapiens	134-144
1582733-3	1992	The ability of monocytes in PBM to produce IL 1-alpha was significantly augmented 3 and 5 days after lentinan administration, as compared with that before treatment.	Lentinan	101-109	interleukin 1 alpha	Homo sapiens	43-53
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	99-103
1371299-3	1992	Paraformaldehyde-fixed macrophages like-wise showed augmentation of IL-1 activity, but whereas all of the bioactivity associated with the fixed macrophages could be neutralized by anti-IL-1 alpha antibody only approximately 40% of the supernate activity could be attributed to IL-1 alpha.	paraform	0-16	interleukin 1 alpha	Homo sapiens	185-195
1517529-3	1992	The greatest Interleukin -1 alpha (IL-1 alpha) production increase was induced by Propofol.	Propofol	82-90	interleukin 1 alpha	Homo sapiens	13-33
1517529-3	1992	The greatest Interleukin -1 alpha (IL-1 alpha) production increase was induced by Propofol.	Propofol	82-90	interleukin 1 alpha	Homo sapiens	35-45
1517533-10	1992	Mercury also inhibited the ability of these cells to synthesize and secrete IL-1.	Mercury	0-7	interleukin 1 alpha	Homo sapiens	76-80
1371299-3	1992	Paraformaldehyde-fixed macrophages like-wise showed augmentation of IL-1 activity, but whereas all of the bioactivity associated with the fixed macrophages could be neutralized by anti-IL-1 alpha antibody only approximately 40% of the supernate activity could be attributed to IL-1 alpha.	paraform	0-16	interleukin 1 alpha	Homo sapiens	277-287
1556675-1	1992	We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%).	Methylprednisolone	53-71	interleukin 1 alpha	Homo sapiens	89-108
1619288-1	1992	Isoniazid in vitro decreased interleukin-1 production by glass-adherent cells from the blood of healthy donors.	Isoniazid	0-9	interleukin 1 alpha	Homo sapiens	29-42
1309881-2	1992	We have previously shown bradykinin to be a potent stimulus for the release of prostanoids from interleukin-1 (IL-1)-treated, but not untreated, human synovial cells.	Prostaglandins	79-90	interleukin 1 alpha	Homo sapiens	96-109
1309881-2	1992	We have previously shown bradykinin to be a potent stimulus for the release of prostanoids from interleukin-1 (IL-1)-treated, but not untreated, human synovial cells.	Prostaglandins	79-90	interleukin 1 alpha	Homo sapiens	111-115
1309881-7	1992	In matched experiments, IL-1 treatment enhanced specific [3H]bradykinin binding 1.5- to 2.0-fold above that observed in untreated cells.	Tritium	58-60	interleukin 1 alpha	Homo sapiens	24-28
1309881-9	1992	The potencies of a series of kinin analogs and antagonists and unrelated peptides in displacing [3H]bradykinin from IL-1-treated cells correlated well with their abilities to induce prostanoid release.	Tritium	97-99	interleukin 1 alpha	Homo sapiens	116-120
1309881-10	1992	These studies provide novel information regarding the nature of kinin receptors in intact human synovia and in cultured human synovial cells, their regulation by IL-1 and their role in IL-1-treated cells in kinin-mediated prostaglandin E2 production.	Dinoprostone	222-238	interleukin 1 alpha	Homo sapiens	185-189
1556675-1	1992	We report that administration of the corticosteroid, methylprednisolone (PRED) inhibited interleukin 1 (IL-1) induction of chondrocyte caseinolytic activity (25-55%) and collagenolytic activity (15-24%).	prednylidene	73-77	interleukin 1 alpha	Homo sapiens	89-108
1619693-2	1992	The results showed that selenium is able to enhance lectin-stimulated T lymphocyte proliferation, to increase the production of interleukin 2 (IL-2) by lymphocytes and interleukin 1 (IL-1) by macrophages in the presence of lectin and to augment the response of T lymphoblasts to IL-2 and that of thymocytes to IL-1.	Selenium	24-32	interleukin 1 alpha	Homo sapiens	168-187
1619693-2	1992	The results showed that selenium is able to enhance lectin-stimulated T lymphocyte proliferation, to increase the production of interleukin 2 (IL-2) by lymphocytes and interleukin 1 (IL-1) by macrophages in the presence of lectin and to augment the response of T lymphoblasts to IL-2 and that of thymocytes to IL-1.	Selenium	24-32	interleukin 1 alpha	Homo sapiens	183-187
1619693-4	1992	Selenium might enhance IL-2 production and response through the augmentation of IL-1 production and response, thereby promoting the enhancement of the proliferation and action of T lymphocytes and other immunocompetent cells.	Selenium	0-8	interleukin 1 alpha	Homo sapiens	80-84
1310515-0	1992	Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor.	tetrandrine	23-34	interleukin 1 alpha	Homo sapiens	93-132
1310515-0	1992	Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor.	berbamine	39-48	interleukin 1 alpha	Homo sapiens	93-132
1310515-1	1992	Tetrandrine and berbamine are bisbenzylisoquinoline compounds which differ from each other in a minor way in terms of chemical structure, yet tetrandrine is 6-18 times more potent than berbamine in terms of inhibitory effects on production of interleukin-1 and tumor necrosis factor (TNF alpha) by monocytes and macrophages, and TNF beta production by lymphocytes.	tetrandrine	0-11	interleukin 1 alpha	Homo sapiens	243-282
1310515-1	1992	Tetrandrine and berbamine are bisbenzylisoquinoline compounds which differ from each other in a minor way in terms of chemical structure, yet tetrandrine is 6-18 times more potent than berbamine in terms of inhibitory effects on production of interleukin-1 and tumor necrosis factor (TNF alpha) by monocytes and macrophages, and TNF beta production by lymphocytes.	berbamine	16-25	interleukin 1 alpha	Homo sapiens	243-282
1310515-1	1992	Tetrandrine and berbamine are bisbenzylisoquinoline compounds which differ from each other in a minor way in terms of chemical structure, yet tetrandrine is 6-18 times more potent than berbamine in terms of inhibitory effects on production of interleukin-1 and tumor necrosis factor (TNF alpha) by monocytes and macrophages, and TNF beta production by lymphocytes.	tetrandrine	142-153	interleukin 1 alpha	Homo sapiens	243-282
1342713-4	1992	With the mounting evidence that TNF, IL-1, and T lymphocyte cytokines affect hemopoiesis and iron metabolism it is possible that the reported discrepancy is a reflection of that inextricable interdependence between the two systems in the face of infection.	Iron	93-97	interleukin 1 alpha	Homo sapiens	37-41
1316577-10	1992	Finally, the presence of LPS in the dialysate compartment led to a moderate increase in interleukin 1 (IL-1) and tumour necrosis factor alpha (TNF) concentrations in plasma as well as in monocyte culture supernatants after isolation from recirculating normal human whole blood exposed to CU, PAN, or PS membrane.	ps	26-28	interleukin 1 alpha	Homo sapiens	88-107
18475442-7	1992	Thus prostaglandin formation in HN or B.Cl-induced inflammation, if IL-1 dependent, is not associated with the loss of significant amounts of the cytokine from the epidermis.	Prostaglandins	5-18	interleukin 1 alpha	Homo sapiens	68-72
18475478-6	1992	Exogenous TNF-alpha (1000-0.5 ng/ml) and IL-1 (500-0.24 ng/ml) had an additive suppressive activity on fibroblast proliferation which was partially reversed by indomethacin.	Indomethacin	160-172	interleukin 1 alpha	Homo sapiens	41-45
18475489-2	1992	As interleukin-1 (IL-1) stimulates keratinocyte PGE synthesis we investigated whether the degree of confluency of the keratinocyte culture modified the response of the cells to IL-1.	Prostaglandins E	48-51	interleukin 1 alpha	Homo sapiens	3-16
18475489-2	1992	As interleukin-1 (IL-1) stimulates keratinocyte PGE synthesis we investigated whether the degree of confluency of the keratinocyte culture modified the response of the cells to IL-1.	Prostaglandins E	48-51	interleukin 1 alpha	Homo sapiens	18-22
18475489-3	1992	It was found that IL-1alpha (100 U/ml) stimulated PGE(2) synthesis by proliferating (7 days in culture) but not differentiating (14 days in culture) keratinocytes.	Prostaglandins E	50-53	interleukin 1 alpha	Homo sapiens	18-27
1317231-4	1992	In the present study, we have evaluated the effect of the anti-inflammatory and antiasthmatic drug, nedocromil sodium, on the spontaneous and IL1-induced expression of GM-CSF in cultured bronchial epithelial cells.	Nedocromil	100-117	interleukin 1 alpha	Homo sapiens	142-145
1292755-1	1992	We have investigated the antiproliferative effects of recombinant human interleukin-1 alpha (IL-1) combined with the cytotoxic antitumor drug doxorubicin against A375 human melanoma IL-1-sensitive (C6) and IL-1-resistant (C5) clonal cell lines.	Doxorubicin	142-153	interleukin 1 alpha	Homo sapiens	182-186
1292755-1	1992	We have investigated the antiproliferative effects of recombinant human interleukin-1 alpha (IL-1) combined with the cytotoxic antitumor drug doxorubicin against A375 human melanoma IL-1-sensitive (C6) and IL-1-resistant (C5) clonal cell lines.	Doxorubicin	142-153	interleukin 1 alpha	Homo sapiens	182-186
1292755-4	1992	The strongest synergism occurred when C6 cells were exposed to IL-1 prior to doxorubicin, and when C5 cells were pretreated with doxorubicin for 6 hr prior to IL-1 additions.	Doxorubicin	77-88	interleukin 1 alpha	Homo sapiens	63-67
1292755-4	1992	The strongest synergism occurred when C6 cells were exposed to IL-1 prior to doxorubicin, and when C5 cells were pretreated with doxorubicin for 6 hr prior to IL-1 additions.	Doxorubicin	129-140	interleukin 1 alpha	Homo sapiens	159-163
1292755-6	1992	Doxorubicin treatment enhanced the binding and internalization of [125I]IL-1 after 24 and 48 hr at 37 degrees C, but IL-1 binding to cells incubated on ice was increased only marginally by doxorubicin pretreatment.	Doxorubicin	0-11	interleukin 1 alpha	Homo sapiens	72-76
1292755-6	1992	Doxorubicin treatment enhanced the binding and internalization of [125I]IL-1 after 24 and 48 hr at 37 degrees C, but IL-1 binding to cells incubated on ice was increased only marginally by doxorubicin pretreatment.	Doxorubicin	189-200	interleukin 1 alpha	Homo sapiens	117-121
1292755-8	1992	A recombinant protein IL-1 receptor antagonist that binds to both the 80 kDa type I and the 65 kDa type II IL-1 receptors, blocked the cytostatic effects of IL-1 and abrogated the synergism with doxorubicin.	Doxorubicin	195-206	interleukin 1 alpha	Homo sapiens	22-26
1317231-0	1992	Protective effect of nedocromil sodium on the IL1-induced release of GM-CSF from cultured human bronchial epithelial cells.	Nedocromil	21-38	interleukin 1 alpha	Homo sapiens	46-49
1744113-8	1991	The other can be activated by stimulation with TNF, interleukin-1, or lipopolysaccharide and in which a protein factor that can be induced by TPA treatment is involved.	Tetradecanoylphorbol Acetate	142-145	interleukin 1 alpha	Homo sapiens	52-65
1475634-14	1992	Thus, for example, cyclosporin A inhibits in vitro the bone resorbing activity of interleukin 1, 1,25-dihydroxy-vitamin D3, parathyroid hormone and prostaglandin E2 by apparently non-T-cell effects, while in vivo protects against bone and cartilage loss in adjuvant arthritis.	Cyclosporine	19-32	interleukin 1 alpha	Homo sapiens	82-95
1837236-0	1991	The role of arginine residues in interleukin 1 receptor binding.	Arginine	12-20	interleukin 1 alpha	Homo sapiens	33-46
1837236-4	1991	Modification of the proteins with phenylglyoxal, an arginine-specific reagent, resulted in the loss of Type 1 IL-1 receptor binding activity.	Phenylglyoxal	34-47	interleukin 1 alpha	Homo sapiens	110-114
1837236-4	1991	Modification of the proteins with phenylglyoxal, an arginine-specific reagent, resulted in the loss of Type 1 IL-1 receptor binding activity.	Arginine	52-60	interleukin 1 alpha	Homo sapiens	110-114
1837236-5	1991	The stoichiometry of this modification revealed that a single arginine in either IL-1 alpha or IL-1 beta is responsible for the loss of activity.	Arginine	62-70	interleukin 1 alpha	Homo sapiens	81-91
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Cyanogen Bromide	0-16	interleukin 1 alpha	Homo sapiens	52-62
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Cyanogen Bromide	0-16	interleukin 1 alpha	Homo sapiens	147-157
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	29-42	interleukin 1 alpha	Homo sapiens	52-62
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	29-42	interleukin 1 alpha	Homo sapiens	147-157
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 alpha	Homo sapiens	52-62
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 alpha	Homo sapiens	147-157
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 alpha	Homo sapiens	52-62
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	283-296	interleukin 1 alpha	Homo sapiens	147-157
1807818-4	1991	The glucocorticosteroids inhibit the synthesis of interleukin-1 (IL-1) by the macrophages and suppress the IL-2 production from the T cells (Palacios, 1982).	glucocorticosteroids	4-24	interleukin 1 alpha	Homo sapiens	50-63
1954872-5	1991	IL-1 alpha mRNA expression in Leydig cells was detectable as early as 2 h after the addition of IL-1 beta (10 ng/ml) and persisted for up to 24 h. Lipopolysaccharide also stimulated IL-1 alpha mRNA expression in these cells, but phorbol ester had no effect.	Phorbol Esters	229-242	interleukin 1 alpha	Homo sapiens	0-10
1807818-4	1991	The glucocorticosteroids inhibit the synthesis of interleukin-1 (IL-1) by the macrophages and suppress the IL-2 production from the T cells (Palacios, 1982).	glucocorticosteroids	4-24	interleukin 1 alpha	Homo sapiens	65-69
1661707-0	1991	Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.	Prostaglandins	88-101	interleukin 1 alpha	Homo sapiens	66-79
1661707-1	1991	The interactions between bradykinin (BK) and interleukin-1 (IL-1) on prostaglandin formation in human gingival fibroblasts have been studied.	Prostaglandins	69-82	interleukin 1 alpha	Homo sapiens	45-64
1661707-2	1991	IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist.	Dinoprostone	36-52	interleukin 1 alpha	Homo sapiens	0-10
1661707-2	1991	IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist.	Dinoprostone	54-58	interleukin 1 alpha	Homo sapiens	0-10
1661707-3	1991	The effects of both IL-1 alpha and IL-1 beta on PGE2 biosynthesis was synergistically potentiated by BK, in a dose-related manner.	Dinoprostone	48-52	interleukin 1 alpha	Homo sapiens	20-30
1661707-6	1991	These data suggest that BK and IL-1 act in concert to enhance prostanoid formation in inflammatory lesions and that the level of interaction is distal to phospholipase activity.	Prostaglandins	62-72	interleukin 1 alpha	Homo sapiens	31-35
1661292-1	1991	The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined.	Cyclic AMP	40-44	interleukin 1 alpha	Homo sapiens	55-65
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	dibutyryl	0-9	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Cyclic AMP	10-14	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	8-Bromo Cyclic Adenosine Monophosphate	16-28	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Colforsin	30-39	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Alprostadil	56-60	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Dinoprostone	66-70	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 alpha	Homo sapiens	144-154
1752957-5	1991	However, eosinophil viability decreased by 21% in dexamethasone-pretreated IL-1 alpha-stimulated endothelial cell-conditioned medium (P less than 0.05), which suggested viability antagonism by glucocorticoids.	Dexamethasone	50-63	interleukin 1 alpha	Homo sapiens	75-85
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	241-244	interleukin 1 alpha	Homo sapiens	144-154
1838853-5	1991	Human interleukin-1 alpha (IL-1, 1 ng/ml) and bovine parathyroid hormone-(1-34) (PTH, 10 ng/ml) increased PGE2 production earlier and to a greater extent than 1,25-(OH)2D3.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	6-25
1955497-6	1991	This report demonstrates for the first time the possibility that IL-1 blocks decidualization, the functional differentiation of human endometrial stromal cells in response to ovarian steroids.	Steroids	183-191	interleukin 1 alpha	Homo sapiens	65-69
1838853-5	1991	Human interleukin-1 alpha (IL-1, 1 ng/ml) and bovine parathyroid hormone-(1-34) (PTH, 10 ng/ml) increased PGE2 production earlier and to a greater extent than 1,25-(OH)2D3.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	27-31
1658153-7	1991	In contrast, NMA enhances the synthesis of both gelatinase and PGE2 after activation with a combination of IL-1, LPS, and TNF-alpha.	omega-N-Methylarginine	13-16	interleukin 1 alpha	Homo sapiens	107-111
1658153-7	1991	In contrast, NMA enhances the synthesis of both gelatinase and PGE2 after activation with a combination of IL-1, LPS, and TNF-alpha.	Dinoprostone	63-67	interleukin 1 alpha	Homo sapiens	107-111
1658153-9	1991	Exposure of IL-1 and fibroblast growth factor-stimulated chondrocytes to authentic, exogenous .N = O led to an increase of PGE2 synthesis from 5.6 +/- 1.7 of untreated cells to 15.8 +/- 6.8 ng/10(6) of .N = O treated cells within the 1st h. This was followed by a suppression of PGE2 synthesis within the next 2 h.	Dinoprostone	123-127	interleukin 1 alpha	Homo sapiens	12-16
1658153-9	1991	Exposure of IL-1 and fibroblast growth factor-stimulated chondrocytes to authentic, exogenous .N = O led to an increase of PGE2 synthesis from 5.6 +/- 1.7 of untreated cells to 15.8 +/- 6.8 ng/10(6) of .N = O treated cells within the 1st h. This was followed by a suppression of PGE2 synthesis within the next 2 h.	Dinoprostone	279-283	interleukin 1 alpha	Homo sapiens	12-16
1940611-6	1991	We report the results of further studies designed to investigate the ability of GM-CSF, erythropoietin, interleukin-1, and lithium to modulate AZT toxicity on murine hematopoietic granulocyte-macrophage (CFU-GM), megakaryocytic (CFU-Meg), and erythroid (BFU-E) progenitors cultured from bone marrow and spleen cells from mice infected with RLV.	Zidovudine	143-146	interleukin 1 alpha	Homo sapiens	104-117
1940611-9	1991	However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced.	Zidovudine	123-126	interleukin 1 alpha	Homo sapiens	28-41
1940611-9	1991	However, in the presence of interleukin-1 (recombinant human IL-1 alpha, 30 ngm) or lithium chloride (ultra-pure, 1.0 mM), AZT toxicity CFU-GM, CFU-Meg, and BFU-E cultured from RLV-infected marrow or spleen cells was reduced.	Zidovudine	123-126	interleukin 1 alpha	Homo sapiens	61-71
1940611-10	1991	These results further demonstrate interleukin-1 and lithium are effective in modulating the toxic action of AZT on hematopoietic progenitors and that RLV-infected animals serve as a useful viral model system to study the effect of agents capable of modulating hematopoiesis in the presence of the anti-viral drug AZT.	Zidovudine	108-111	interleukin 1 alpha	Homo sapiens	34-47
1822334-3	1991	It is suggested that interleukin-1 causes both changes by 1) increasing the metallothionein-mediated hepatic uptake to serum Zn and 2) upregulating ceruloplasmin (acute phase reactant) gene and synthesis in liver and subsequently the level of ceruloplasmin-Cu complexes in the blood.	Zinc	125-127	interleukin 1 alpha	Homo sapiens	21-34
1822334-3	1991	It is suggested that interleukin-1 causes both changes by 1) increasing the metallothionein-mediated hepatic uptake to serum Zn and 2) upregulating ceruloplasmin (acute phase reactant) gene and synthesis in liver and subsequently the level of ceruloplasmin-Cu complexes in the blood.	Copper	257-259	interleukin 1 alpha	Homo sapiens	21-34
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Formaldehyde	78-86	interleukin 1 alpha	Homo sapiens	41-51
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Paraffin	93-101	interleukin 1 alpha	Homo sapiens	41-51
1665456-1	1991	The monokine interleukin-1 alpha (IL-1) induces a glucose-dependent increase in insulin secretion, an effect tentatively attributed to its ability to increase beta cell phosphoinositide (PI) hydrolysis.	Glucose	50-57	interleukin 1 alpha	Homo sapiens	13-32
1665456-1	1991	The monokine interleukin-1 alpha (IL-1) induces a glucose-dependent increase in insulin secretion, an effect tentatively attributed to its ability to increase beta cell phosphoinositide (PI) hydrolysis.	Glucose	50-57	interleukin 1 alpha	Homo sapiens	34-38
1665456-1	1991	The monokine interleukin-1 alpha (IL-1) induces a glucose-dependent increase in insulin secretion, an effect tentatively attributed to its ability to increase beta cell phosphoinositide (PI) hydrolysis.	Phosphatidylinositols	169-185	interleukin 1 alpha	Homo sapiens	13-32
1665456-1	1991	The monokine interleukin-1 alpha (IL-1) induces a glucose-dependent increase in insulin secretion, an effect tentatively attributed to its ability to increase beta cell phosphoinositide (PI) hydrolysis.	Phosphatidylinositols	169-185	interleukin 1 alpha	Homo sapiens	34-38
1665456-3	1991	In perifused islets, insulin secretion in response to IL-1 in the presence of 7 mM glucose averaged 313 +/- 43 pg/islet/min 35-40 min after the onset of stimulation.	Glucose	83-90	interleukin 1 alpha	Homo sapiens	54-58
1665456-6	1991	This level of IL-1 caused significant increases in inositol phosphate accumulation in the presence of 7 mM glucose but not 2.75 mM glucose.	Inositol Phosphates	51-69	interleukin 1 alpha	Homo sapiens	14-18
1665456-6	1991	This level of IL-1 caused significant increases in inositol phosphate accumulation in the presence of 7 mM glucose but not 2.75 mM glucose.	Glucose	107-114	interleukin 1 alpha	Homo sapiens	14-18
1665456-11	1991	These results emphasize the role of PI hydrolysis in IL-1-induced insulin secretion and suggest further that calcium influx is essential for IL-1 to fully activate both PI hydrolysis and insulin secretion.	Calcium	109-116	interleukin 1 alpha	Homo sapiens	141-145
1726126-7	1991	Essential fatty acids, the precursors of eicosanoids, are suppressors of T-cell proliferation, IL-1, IL-2 and TNF production and have been shown to be of benefit in rheumatoid arthritis, systemic lupus erythematosus and glomerulonephritis.	Fatty Acids, Essential	0-21	interleukin 1 alpha	Homo sapiens	95-99
1726126-7	1991	Essential fatty acids, the precursors of eicosanoids, are suppressors of T-cell proliferation, IL-1, IL-2 and TNF production and have been shown to be of benefit in rheumatoid arthritis, systemic lupus erythematosus and glomerulonephritis.	Eicosanoids	41-52	interleukin 1 alpha	Homo sapiens	95-99
1815239-0	1991	Synergistic stimulation of amnion cell prostaglandin E2 synthesis by interleukin-1, tumor necrosis factor and products from activated human granulocytes.	Dinoprostone	39-55	interleukin 1 alpha	Homo sapiens	69-105
1815239-1	1991	We examined the interactions between supernatant from FMLP-activated human granulocytes, recombinant interleukin-1 (IL-1) and recombinant tumor necrosis factor (TNF) in the stimulation of prostaglandin E2 (PGE2) production by human amnion cells.	Dinoprostone	188-204	interleukin 1 alpha	Homo sapiens	101-120
1815239-1	1991	We examined the interactions between supernatant from FMLP-activated human granulocytes, recombinant interleukin-1 (IL-1) and recombinant tumor necrosis factor (TNF) in the stimulation of prostaglandin E2 (PGE2) production by human amnion cells.	Dinoprostone	206-210	interleukin 1 alpha	Homo sapiens	101-120
1815239-7	1991	The combinations of IL-1 alpha or IL-1 beta with either TNF-alpha or TNF-beta caused a synergistic stimulation of amnion cell PGE2 production as well, whereas the combinations of IL-1 alpha with IL-1 beta or of TNF-alpha with TNF-beta were not synergistic.	Dinoprostone	126-130	interleukin 1 alpha	Homo sapiens	20-30
1790304-4	1991	In this study we examined the ability of taurolidine to block LPS-induced tumor necrosis factor (TNF) and interleukin 1 (IL-1) synthesis in human peripheral blood mononuclear cells (PBMC) from 27 donors.	taurolidine	41-52	interleukin 1 alpha	Homo sapiens	106-125
1658153-2	1991	The present study shows that IL-1 induces the biosynthesis of nitric oxide (.N = O) by articular chondrocytes.	Nitric Oxide	62-74	interleukin 1 alpha	Homo sapiens	29-33
1658153-5	1991	A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation.	Nitrites	120-127	interleukin 1 alpha	Homo sapiens	17-21
1658153-5	1991	A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation.	Nitrogen Dioxide	129-132	interleukin 1 alpha	Homo sapiens	17-21
1658153-6	1991	The biosynthesis of .N = O requires an induction period of approximately 6 h and continues for at least 72 h. Inhibition of .N = O production with the competitive inhibitor NG-monomethyl-L-arginine (NMA) leads to a suppression of gelatinase and PGE2 synthesis by chondrocytes activated with IL-1 alone.	omega-N-Methylarginine	173-197	interleukin 1 alpha	Homo sapiens	291-295
1658153-6	1991	The biosynthesis of .N = O requires an induction period of approximately 6 h and continues for at least 72 h. Inhibition of .N = O production with the competitive inhibitor NG-monomethyl-L-arginine (NMA) leads to a suppression of gelatinase and PGE2 synthesis by chondrocytes activated with IL-1 alone.	omega-N-Methylarginine	199-202	interleukin 1 alpha	Homo sapiens	291-295
1742333-1	1991	In addition, PMA inhibited endogenous and interleukin-1 (IL-1) induced plasminogen activator (PA) activity, while increasing mRNA PAI-1 levels.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	42-55
1742333-1	1991	In addition, PMA inhibited endogenous and interleukin-1 (IL-1) induced plasminogen activator (PA) activity, while increasing mRNA PAI-1 levels.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	57-61
1717193-1	1991	All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb).	Tretinoin	4-23	interleukin 1 alpha	Homo sapiens	189-217
1717193-1	1991	All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb).	Tretinoin	4-23	interleukin 1 alpha	Homo sapiens	219-229
1717193-1	1991	All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb).	Tretinoin	25-29	interleukin 1 alpha	Homo sapiens	189-217
1717193-1	1991	All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb).	Tretinoin	25-29	interleukin 1 alpha	Homo sapiens	219-229
1934598-4	1991	Although both steroids decreased IL-1 secretion from human monocytes stimulated with lipopolysaccharide (LPS), they exert the same effect through a different mechanism.	Steroids	14-22	interleukin 1 alpha	Homo sapiens	33-37
1915666-3	1991	In contrast, when cells were individually stimulated by soluble substances including a protein kinase C activating phorbol ester, the production of interleukin 1 and interleukin 2 was dramatically inhibited during microgravity exposure.	Phorbol Esters	115-128	interleukin 1 alpha	Homo sapiens	148-161
1839507-2	1991	The RRA is based on the competition between human 125I-labeled rIL-1 alpha and standard or unknown quantities of IL-1 alpha or IL-1 beta for binding to a limited amounts of IL-1 receptor (IL-1R) isolated from the EL4 mouse thymoma cell line.	Iodine-125	50-54	interleukin 1 alpha	Homo sapiens	64-74
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	96-117	interleukin 1 alpha	Homo sapiens	30-40
1839507-5	1991	When plasma samples with inhibiting activity were incubated with labeled IL-1 alpha and chromatographed on a Sephadex G200 column, they were found to contain 125I-labeled complexes with an apparent molecular weight of 150-200kD.	sephadex	109-117	interleukin 1 alpha	Homo sapiens	73-83
1663075-6	1991	PMA priming, which has been reported to up-regulate scavenger receptor expression in THP-1 cells, significantly enhanced IL-1 production by fucoidan and poly I.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	121-125
1663075-8	1991	Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production.	Cyclic AMP	133-143	interleukin 1 alpha	Homo sapiens	28-32
1663075-8	1991	Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production.	Cyclic AMP	213-223	interleukin 1 alpha	Homo sapiens	28-32
1663075-8	1991	Scavenger receptor-mediated IL-1 production was inhibited by H7, a protein kinase C inhibitor, and enhanced by IBMX, an inhibitor of cyclic AMP degradation, suggesting a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavenger receptor-mediated IL-1 production.	Cyclic AMP	213-223	interleukin 1 alpha	Homo sapiens	293-297
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	119-122	interleukin 1 alpha	Homo sapiens	30-40
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	127-130	interleukin 1 alpha	Homo sapiens	30-40
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	Ionomycin	136-145	interleukin 1 alpha	Homo sapiens	30-40
1660901-0	1991	Time course of IL1 and IL6 synthesis and release in human bronchial epithelial cell cultures exposed to toluene diisocyanate.	Toluene 2,4-Diisocyanate	104-124	interleukin 1 alpha	Homo sapiens	15-18
1937785-2	1991	The inhibitory activity could be detected after the depletion of IL-1 alpha by the use of a specific antibody (anti-human recombinant IL-1 alpha monoclonal antibody)-conjugated Sepharose column.	Sepharose	177-186	interleukin 1 alpha	Homo sapiens	65-75
1937785-2	1991	The inhibitory activity could be detected after the depletion of IL-1 alpha by the use of a specific antibody (anti-human recombinant IL-1 alpha monoclonal antibody)-conjugated Sepharose column.	Sepharose	177-186	interleukin 1 alpha	Homo sapiens	134-144
1660901-1	1991	We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro.	Toluene 2,4-Diisocyanate	161-181	interleukin 1 alpha	Homo sapiens	101-114
1660901-1	1991	We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro.	Toluene 2,4-Diisocyanate	161-181	interleukin 1 alpha	Homo sapiens	116-119
1660901-1	1991	We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro.	Toluene 2,4-Diisocyanate	183-186	interleukin 1 alpha	Homo sapiens	101-114
1660901-1	1991	We have previously demonstrated that human bronchial epithelial cells release appreciable amounts of interleukin 1 (IL1) and interleukin 6 (IL6) when exposed to toluene diisocyanate (TDI) in vitro.	Toluene 2,4-Diisocyanate	183-186	interleukin 1 alpha	Homo sapiens	116-119
1660901-3	1991	The epithelial cell-derived IL1 and IL6 can promote T cell activation and proliferation in culture, and if this also happens in vivo they may contribute to the persistence of the inflammatory response of the bronchial mucosa observed in TDI-sensitive asthmatics.	Toluene 2,4-Diisocyanate	237-240	interleukin 1 alpha	Homo sapiens	28-31
1834696-9	1991	IL-1 alpha may play an intracellular role in regulating senescence; an IL-1 alpha antisense oligodeoxynucleotide was shown to prolong the life span of cultured human endothelial cells.	Oligodeoxyribonucleotides	92-112	interleukin 1 alpha	Homo sapiens	71-81
1717608-0	1991	Responses of human dermal microvascular endothelial cells to histamine and their modulation by interleukin 1 and substance P.	Histamine	61-70	interleukin 1 alpha	Homo sapiens	95-108
1717608-5	1991	Interleukin-1 induces a concentration-dependent release of prostaglandin E2 following 24 h incubation.	Dinoprostone	59-75	interleukin 1 alpha	Homo sapiens	0-13
1717608-7	1991	In cells incubated with 1 U/ml human recombinant interleukin 1 alpha for 24 h prior to stimulation with histamine (10(-5)-10(-3) M) for 30 min, there is a significant potentiation of histamine-induced release of prostaglandin E2 (p less than 0.05).	Histamine	104-113	interleukin 1 alpha	Homo sapiens	49-68
1717608-7	1991	In cells incubated with 1 U/ml human recombinant interleukin 1 alpha for 24 h prior to stimulation with histamine (10(-5)-10(-3) M) for 30 min, there is a significant potentiation of histamine-induced release of prostaglandin E2 (p less than 0.05).	Histamine	183-192	interleukin 1 alpha	Homo sapiens	49-68
1717608-7	1991	In cells incubated with 1 U/ml human recombinant interleukin 1 alpha for 24 h prior to stimulation with histamine (10(-5)-10(-3) M) for 30 min, there is a significant potentiation of histamine-induced release of prostaglandin E2 (p less than 0.05).	Dinoprostone	212-228	interleukin 1 alpha	Homo sapiens	49-68
1717608-8	1991	Using a solubilized cell sonicate prepared from human dermal microvascular endothelial cells incubated with 1 U/ml human recombinant interleukin 1 alpha for 24 h, conversion of exogenous arachidonic acid into prostaglandin E2 increased by 60.19 +/- 18.28%.	Arachidonic Acid	187-203	interleukin 1 alpha	Homo sapiens	133-152
1717608-8	1991	Using a solubilized cell sonicate prepared from human dermal microvascular endothelial cells incubated with 1 U/ml human recombinant interleukin 1 alpha for 24 h, conversion of exogenous arachidonic acid into prostaglandin E2 increased by 60.19 +/- 18.28%.	Dinoprostone	209-225	interleukin 1 alpha	Homo sapiens	133-152
1717608-9	1991	Cycloheximide partially reduces the increased conversion but completely blocks interleukin-1-induced release of prostaglandin E2 from intact cells.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	79-92
1717608-9	1991	Cycloheximide partially reduces the increased conversion but completely blocks interleukin-1-induced release of prostaglandin E2 from intact cells.	Dinoprostone	112-128	interleukin 1 alpha	Homo sapiens	79-92
1717608-11	1991	These results demonstrate that human dermal microvascular endothelial cells are responsive to histamine and that interleukin-1, but not substance P, can potentiate histamine-induced release of <protein-id="3552">prostaglandin E2.	Histamine	164-173	interleukin 1 alpha	Homo sapiens	113-126
1717608-13	1991	Interactions between histamine and interleukin-1 may be important in the modulation of inflammatory reactions in skin.	Histamine	21-30	interleukin 1 alpha	Homo sapiens	35-48
1717650-5	1991	The increases in brain tryptophan caused by intraperitoneal injection of endotoxin or interleukin-1 (IL-1) were also prevented by chlorisondamine pretreatment.	Tryptophan	23-33	interleukin 1 alpha	Homo sapiens	73-105
1577097-2	1992	However, IL-1 also induces the synthesis by stromal cells of inhibitors of hemopoiesis including tumor necrosis factor (TNF) and prostaglandin E2.	Dinoprostone	129-145	interleukin 1 alpha	Homo sapiens	9-13
1717650-5	1991	The increases in brain tryptophan caused by intraperitoneal injection of endotoxin or interleukin-1 (IL-1) were also prevented by chlorisondamine pretreatment.	Chlorisondamine	130-145	interleukin 1 alpha	Homo sapiens	73-105
1717650-10	1991	Endotoxin and IL-1 also elevate brain tryptophan, presumably by a similar mechanism.	Tryptophan	38-48	interleukin 1 alpha	Homo sapiens	14-18
1657905-0	1991	Cyclic adenosine 3",5"-monophosphate suppresses interleukin 1-induced synthesis of matrix metalloproteinases but not of tissue inhibitor of metalloproteinases in human uterine cervical fibroblasts.	Cyclic AMP	0-36	interleukin 1 alpha	Homo sapiens	48-61
1823998-1	1991	Effects of Polyactin A (PAA) on abilities of human monocytes to synthesize and secrete interleukin-1 (IL-1) and to modulate natural killer (NK) cell activity in large granular lymphocytes (LGL) were investigated in vitro.	polyactin A	24-27	interleukin 1 alpha	Homo sapiens	87-107
1823998-2	1991	Over a wide range of concentrations (0.01-100 micrograms.ml-1), PAA directly induced IL-1 synthesis and secretion, showing the maximal effect at 10 micrograms.ml-1, and evidently synergized with lipopolysaccharides (LPS) of E coli in stimulation of IL-1 production by human monocytes.	polyactin A	64-67	interleukin 1 alpha	Homo sapiens	85-89
1823998-2	1991	Over a wide range of concentrations (0.01-100 micrograms.ml-1), PAA directly induced IL-1 synthesis and secretion, showing the maximal effect at 10 micrograms.ml-1, and evidently synergized with lipopolysaccharides (LPS) of E coli in stimulation of IL-1 production by human monocytes.	polyactin A	64-67	interleukin 1 alpha	Homo sapiens	249-253
1823998-5	1991	These results demonstrate significant effects of PAA on functions of human monocytes, enhancing IL-1 production and affecting their regulative activity on NK cell cytotoxicity.	polyactin A	49-52	interleukin 1 alpha	Homo sapiens	96-100
1657905-2	1991	Here, we have examined the exact participation of cAMP in the IL-1-induced production of the precursors of matrix metalloproteinase (MMPs) and their specific inhibitor, tissue inhibitor of metalloproteinases (TIMP) in human uterine cervical fibroblasts.	Cyclic AMP	50-54	interleukin 1 alpha	Homo sapiens	62-66
1657905-3	1991	IL-1 significantly augmented the production of proMMP-1 (vertebrate procollagenase), proMMP-3 (prostromelysin), and TIMP without detectable changes in the intracellular level of cAMP.	Cyclic AMP	178-182	interleukin 1 alpha	Homo sapiens	0-4
1657905-5	1991	On the contrary, the IL-1-mediated induction of proMMP-1 and proMMP-3 was significantly suppressed by treatment of the cells with Bt2cAMP, forskolin, or theophylline.	Bucladesine	130-137	interleukin 1 alpha	Homo sapiens	21-25
1657905-5	1991	On the contrary, the IL-1-mediated induction of proMMP-1 and proMMP-3 was significantly suppressed by treatment of the cells with Bt2cAMP, forskolin, or theophylline.	Colforsin	139-148	interleukin 1 alpha	Homo sapiens	21-25
1657905-5	1991	On the contrary, the IL-1-mediated induction of proMMP-1 and proMMP-3 was significantly suppressed by treatment of the cells with Bt2cAMP, forskolin, or theophylline.	Theophylline	153-165	interleukin 1 alpha	Homo sapiens	21-25
1773338-2	1991	The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), are two pyrogens which stimulate brain PGE2 formation during fever and also increase PGE2 synthesis in human mononuclear cells in vitro.	Dinoprostone	108-112	interleukin 1 alpha	Homo sapiens	15-28
1657905-6	1991	The suppressive effect of Bt2cAMP on the IL-1-induced production of proMMP-1 and -3 was not due to the inhibition of zymogen secretion, but resulted from the decrease in the steady-state levels of proMMP-1 and proMMP-3 mRNAs.	Bucladesine	26-33	interleukin 1 alpha	Homo sapiens	41-45
1773338-2	1991	The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), are two pyrogens which stimulate brain PGE2 formation during fever and also increase PGE2 synthesis in human mononuclear cells in vitro.	Dinoprostone	108-112	interleukin 1 alpha	Homo sapiens	30-34
1773338-2	1991	The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), are two pyrogens which stimulate brain PGE2 formation during fever and also increase PGE2 synthesis in human mononuclear cells in vitro.	Dinoprostone	154-158	interleukin 1 alpha	Homo sapiens	15-28
1773338-2	1991	The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), are two pyrogens which stimulate brain PGE2 formation during fever and also increase PGE2 synthesis in human mononuclear cells in vitro.	Dinoprostone	154-158	interleukin 1 alpha	Homo sapiens	30-34
1657905-7	1991	In contrast, Bt2cAMP slightly enhanced the IL-1-induced production of TIMP.	Bucladesine	13-20	interleukin 1 alpha	Homo sapiens	43-47
1834679-0	1991	GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle: role of histamine.	Histamine	78-87	interleukin 1 alpha	Homo sapiens	27-31
1913664-0	1991	Potentiation of mitomycin C and porfiromycin antitumor activity in solid tumor models by recombinant human interleukin 1 alpha.	Mitomycin	16-27	interleukin 1 alpha	Homo sapiens	107-126
1913664-0	1991	Potentiation of mitomycin C and porfiromycin antitumor activity in solid tumor models by recombinant human interleukin 1 alpha.	Porfiromycin	32-44	interleukin 1 alpha	Homo sapiens	107-126
1913664-1	1991	The time- and dose-dependent effects of recombinant human interleukin 1 alpha (IL-1 alpha) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems.	Mitomycin	120-131	interleukin 1 alpha	Homo sapiens	58-77
1913664-1	1991	The time- and dose-dependent effects of recombinant human interleukin 1 alpha (IL-1 alpha) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems.	Mitomycin	120-131	interleukin 1 alpha	Homo sapiens	79-89
1913664-1	1991	The time- and dose-dependent effects of recombinant human interleukin 1 alpha (IL-1 alpha) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems.	Mitomycin	133-136	interleukin 1 alpha	Homo sapiens	79-89
1913664-1	1991	The time- and dose-dependent effects of recombinant human interleukin 1 alpha (IL-1 alpha) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems.	Porfiromycin	142-154	interleukin 1 alpha	Homo sapiens	58-77
1913664-1	1991	The time- and dose-dependent effects of recombinant human interleukin 1 alpha (IL-1 alpha) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems.	Porfiromycin	142-154	interleukin 1 alpha	Homo sapiens	79-89
1913664-2	1991	IL-1 alpha produced dose-dependent sensitization of clonogenic RIF-1 tumor cells to MMC in vivo.	Mitomycin	84-87	interleukin 1 alpha	Homo sapiens	0-10
1913664-4	1991	More than additive clonogenic cell kill after IL-1 alpha-chemotherapy combinations reflected increased cellular sensitivity to MMC and PORF.	Mitomycin	127-130	interleukin 1 alpha	Homo sapiens	46-56
1913664-6	1991	Dexamethasone inhibited and ketoconazole, an inhibitor of corticosterone biosynthesis, enhanced IL-1 alpha-mediated chemosensitization in these models.	Ketoconazole	28-40	interleukin 1 alpha	Homo sapiens	96-106
1913664-6	1991	Dexamethasone inhibited and ketoconazole, an inhibitor of corticosterone biosynthesis, enhanced IL-1 alpha-mediated chemosensitization in these models.	Corticosterone	58-72	interleukin 1 alpha	Homo sapiens	96-106
1759822-3	1991	We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide.	Erythromycin	85-97	interleukin 1 alpha	Homo sapiens	138-157
1759822-3	1991	We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide.	Erythromycin	85-97	interleukin 1 alpha	Homo sapiens	160-170
1951564-2	1991	Interleukin-1 is produced by human decidua, stimulates prostaglandin production by intrauterine tissues, and is present in the amniotic fluid of women with preterm labor and intraamniotic infection.	Prostaglandins	55-68	interleukin 1 alpha	Homo sapiens	0-13
1834679-8	1991	Taken together, our data support the conclusion that IL-1 makes CFU-S sensitive to GM-CSF-induced endogeneous histamine that will trigger them into cell cycle, while GM-CSF alone has no such effect on this biological activity.	Histamine	110-119	interleukin 1 alpha	Homo sapiens	53-57
1724348-1	1991	The effect of SP on recombinant human IL-1 alpha-induced cartilage degradation in rabbit knees was investigated.	TFF2 protein, human	14-16	interleukin 1 alpha	Homo sapiens	38-48
1918951-8	1991	The studies demonstrate that both membrane-associated IL-1 and the IL-1 precursor are acylated with palmitic acid.	Palmitic Acid	100-113	interleukin 1 alpha	Homo sapiens	54-58
1918951-8	1991	The studies demonstrate that both membrane-associated IL-1 and the IL-1 precursor are acylated with palmitic acid.	Palmitic Acid	100-113	interleukin 1 alpha	Homo sapiens	67-71
1918951-0	1991	Acylation of cell-associated IL-1 by palmitic acid.	Palmitic Acid	37-50	interleukin 1 alpha	Homo sapiens	29-33
1918951-3	1991	When the monocytes were labeled with [3H]palmitate, 23- and 31-kDa bands were visualized, for membrane-associated IL-1 and its precursor, respectively.	3h]palmitate	38-50	interleukin 1 alpha	Homo sapiens	114-118
1911708-3	1991	Interleukin-1 (IL-1, 1-10 ng/ml) modestly increased the synthesis of collagens I and III (measured by tritiated proline incorporation into specific electrophoretic bands), whereas transforming growth factor-beta (TGF-beta) or platelet-derived growth factor (PDGF) markedly stimulated production of these interstitial collagens.	Proline	112-119	interleukin 1 alpha	Homo sapiens	0-25
1793049-1	1991	Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD).	triclinic monosodium urate	140-166	interleukin 1 alpha	Homo sapiens	89-108
1793049-1	1991	Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD).	Uric Acid	168-171	interleukin 1 alpha	Homo sapiens	89-108
1793049-1	1991	Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD).	Calcium Pyrophosphate	177-208	interleukin 1 alpha	Homo sapiens	89-108
1793049-4	1991	Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles.	Colchicine	0-10	interleukin 1 alpha	Homo sapiens	45-49
1793049-5	1991	However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals.	Colchicine	9-19	interleukin 1 alpha	Homo sapiens	42-46
1838898-4	1991	Both resting and activated synoviocytes contained mRNA for basic fibroblast growth factor (bFGF) which is a synergist for IL-1 induced NMP production, and secreted bFGF into their culture media.	N-methylpyrrolidone	135-138	interleukin 1 alpha	Homo sapiens	122-126
1893621-1	1991	We have developed a quantitative assay for IgG autoantibodies against IL-1 alpha using protein A-Sepharose CL-4B.	Sepharose CL 4B	97-112	interleukin 1 alpha	Homo sapiens	70-80
1874169-10	1991	Tracer studies with radiolabeled steroid substrates suggested that IL-1-attenuated ovarian androsterone accumulation is due, if only in part, to inhibition of transformations catalyzed by (theca-interstitial) 17 alpha-hydroxylase/17:20 lyase, stimulation of theca-interstitial (or granulosa 20 alpha-hydroxysteroid dehydrogenase-mediated conversions, or both.	Steroids	33-40	interleukin 1 alpha	Homo sapiens	67-71
1714833-11	1991	Dexamethasone (10(-6) M) suppressed both basal and IL-1- and TNF-induced IL-6 mRNA expression.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	51-77
1874169-10	1991	Tracer studies with radiolabeled steroid substrates suggested that IL-1-attenuated ovarian androsterone accumulation is due, if only in part, to inhibition of transformations catalyzed by (theca-interstitial) 17 alpha-hydroxylase/17:20 lyase, stimulation of theca-interstitial (or granulosa 20 alpha-hydroxysteroid dehydrogenase-mediated conversions, or both.	Androsterone	91-103	interleukin 1 alpha	Homo sapiens	67-71
1874173-0	1991	Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome P450 expression in primary cultures of Leydig cells.	Cholesterol	23-34	interleukin 1 alpha	Homo sapiens	0-13
1874173-2	1991	We have reported that IL-1 inhibited hCG-induced cAMP and testosterone formation.	Cyclic AMP	49-53	interleukin 1 alpha	Homo sapiens	22-26
1874173-2	1991	We have reported that IL-1 inhibited hCG-induced cAMP and testosterone formation.	Testosterone	58-70	interleukin 1 alpha	Homo sapiens	22-26
1874173-3	1991	In the present study we evaluated the effect of IL-1 on Leydig cell cholesterol side-chain cleavage cytochrome P450 (P450scc) mRNA levels.	Cholesterol	68-79	interleukin 1 alpha	Homo sapiens	48-52
1654497-0	1991	Tumor necrosis factor-alpha, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells.	Triglycerides	75-87	interleukin 1 alpha	Homo sapiens	29-42
1875058-6	1991	Supernatants from melanocyte cultures stimulated with either IL-1 alpha or TNF alpha and separated on a heparin-Sepharose column became positive for neutrophil and monocyte chemotactic activity in a dose- and time-dependent fashion.	Heparin	104-111	interleukin 1 alpha	Homo sapiens	61-71
1875058-6	1991	Supernatants from melanocyte cultures stimulated with either IL-1 alpha or TNF alpha and separated on a heparin-Sepharose column became positive for neutrophil and monocyte chemotactic activity in a dose- and time-dependent fashion.	Sepharose	112-121	interleukin 1 alpha	Homo sapiens	61-71
1654497-2	1991	We now show that TNF-alpha, IL-1, and IFN-alpha stimulate lipogenesis as measured by the incorporation of 3H-glycerol into triglyceride in cultured HepG2 cells.	3h-glycerol	106-117	interleukin 1 alpha	Homo sapiens	28-32
1654497-2	1991	We now show that TNF-alpha, IL-1, and IFN-alpha stimulate lipogenesis as measured by the incorporation of 3H-glycerol into triglyceride in cultured HepG2 cells.	Triglycerides	123-135	interleukin 1 alpha	Homo sapiens	28-32
1654497-6	1991	Cells treated with TNF or IL-1 also showed increased secretion of labeled triglyceride into the media.	Triglycerides	74-86	interleukin 1 alpha	Homo sapiens	26-30
1651357-6	1991	Similar results were obtained for the effect of dexamethasone on the induction of SAA by IL-6 plus IL-1 alpha.	Dexamethasone	48-61	interleukin 1 alpha	Homo sapiens	99-109
1859477-3	1991	Simultaneous addition of the PKC antagonist, staurosporine, blocked the mezerein-induced inhibition of IL-1 activity on both proteoglycan degradation and synthesis in a concentration-related manner.	mezerein	72-80	interleukin 1 alpha	Homo sapiens	103-107
1830582-10	1991	After cross-linking of IL-1 to cells followed by specific immunoprecipitation, sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a band at 85 kDa corresponding to the 68-kDa IL-1RtII.	Sodium Dodecyl Sulfate	79-101	interleukin 1 alpha	Homo sapiens	23-27
1830582-10	1991	After cross-linking of IL-1 to cells followed by specific immunoprecipitation, sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a band at 85 kDa corresponding to the 68-kDa IL-1RtII.	polyacrylamide	102-116	interleukin 1 alpha	Homo sapiens	23-27
1859477-0	1991	Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 (PGE2) release and inhibits proteoglycan synthesis by cartilage in organ culture.	Dinoprostone	181-197	interleukin 1 alpha	Homo sapiens	14-27
1859477-6	1991	These data indicate that the effects of IL-1 on proteoglycan metabolism and prostaglandin production are mediated by an intracellular signal distinct from PKC and suggest that activation of PKC in chondrocytes may play a role in modulating the action of IL-1 on proteoglycan metabolism.	Prostaglandins	76-89	interleukin 1 alpha	Homo sapiens	40-44
1859477-0	1991	Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 (PGE2) release and inhibits proteoglycan synthesis by cartilage in organ culture.	Dinoprostone	181-197	interleukin 1 alpha	Homo sapiens	120-133
2060021-1	1991	In this study, we investigated the effect of human recombinant interleukin-1 alpha (IL-1 alpha) on antigen-presenting cell (APC) activity of spleen cells in mice treated with 5-fluorouracil (5-FU).	Fluorouracil	175-189	interleukin 1 alpha	Homo sapiens	84-94
1859477-0	1991	Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 (PGE2) release and inhibits proteoglycan synthesis by cartilage in organ culture.	Dinoprostone	181-197	interleukin 1 alpha	Homo sapiens	135-139
1859477-0	1991	Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 (PGE2) release and inhibits proteoglycan synthesis by cartilage in organ culture.	Dinoprostone	199-203	interleukin 1 alpha	Homo sapiens	14-27
1859477-0	1991	Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 (PGE2) release and inhibits proteoglycan synthesis by cartilage in organ culture.	Dinoprostone	199-203	interleukin 1 alpha	Homo sapiens	120-133
1859477-1	1991	Addition of the protein kinase C (PKC) activator, mezerein, resulted in the concentration-dependent inhibition of IL-1 activity on proteoglycan metabolism.	mezerein	50-58	interleukin 1 alpha	Homo sapiens	114-118
1859477-3	1991	Simultaneous addition of the PKC antagonist, staurosporine, blocked the mezerein-induced inhibition of IL-1 activity on both proteoglycan degradation and synthesis in a concentration-related manner.	Staurosporine	45-58	interleukin 1 alpha	Homo sapiens	103-107
1864014-2	1991	After 7 days of ciprofloxacin, the extracellular and cellular production of TNF-alpha, the cellular production of IL-1 activity, the extracellular and cellular production of IL-1 alpha, and the cellular production of IL-6 increased significantly.	Ciprofloxacin	16-29	interleukin 1 alpha	Homo sapiens	174-184
2060021-1	1991	In this study, we investigated the effect of human recombinant interleukin-1 alpha (IL-1 alpha) on antigen-presenting cell (APC) activity of spleen cells in mice treated with 5-fluorouracil (5-FU).	Fluorouracil	191-195	interleukin 1 alpha	Homo sapiens	63-82
2065663-5	1991	NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.	Sulfhydryl Compounds	14-19	interleukin 1 alpha	Homo sapiens	163-176
1893956-7	1991	These results demonstrate that the survival of human marrow CFU-GM and BFU-E can be influenced by IL-1, IL-6, LF, and T-lymphocytes.	1-(5-bromo-pyridin-2-yl)-3-[2-(6-fluoro-2-hydroxy-3-propionyl-phenyl)-cyclopropyl]-urea	71-74	interleukin 1 alpha	Homo sapiens	98-102
1662225-6	1991	However, at the highest concentration tested (50 IU/ml), IL-1 alpha enhanced cyclic AMP accumulation over that seen with LH alone.	Cyclic AMP	77-87	interleukin 1 alpha	Homo sapiens	57-67
1662225-6	1991	However, at the highest concentration tested (50 IU/ml), IL-1 alpha enhanced cyclic AMP accumulation over that seen with LH alone.	Luteinizing Hormone	121-123	interleukin 1 alpha	Homo sapiens	57-67
1662225-0	1991	Interleukin-1 alpha modulates luteinizing hormone stimulated cyclic AMP and progesterone release from human granulosa cells in vitro.	Cyclic AMP	61-71	interleukin 1 alpha	Homo sapiens	0-19
1662225-4	1991	IL-1 alpha stimulated basal as well as LH-induced progesterone accumulation.	Luteinizing Hormone	39-41	interleukin 1 alpha	Homo sapiens	0-10
1662225-4	1991	IL-1 alpha stimulated basal as well as LH-induced progesterone accumulation.	Progesterone	50-62	interleukin 1 alpha	Homo sapiens	0-10
1831824-2	1991	IL-1 alpha BF was identified as IgG (1) by sucrose density-gradient centrifugation followed by immunodiffusion autoradiography, (2) by ligand-blotting method, (3) by ligand binding to affinity-immobilized serum IgG, and (4) by IgG affinity purification followed by sucrose density-gradient centrifugation.	Sucrose	43-50	interleukin 1 alpha	Homo sapiens	0-10
1831824-2	1991	IL-1 alpha BF was identified as IgG (1) by sucrose density-gradient centrifugation followed by immunodiffusion autoradiography, (2) by ligand-blotting method, (3) by ligand binding to affinity-immobilized serum IgG, and (4) by IgG affinity purification followed by sucrose density-gradient centrifugation.	Sucrose	265-272	interleukin 1 alpha	Homo sapiens	0-10
1662225-7	1991	At a lower concentration, IL-1 alpha either had no effect or was slightly inhibitory to the LH-induced cyclic AMP accumulation, depending on the culture period.	Luteinizing Hormone	92-94	interleukin 1 alpha	Homo sapiens	26-36
1662225-7	1991	At a lower concentration, IL-1 alpha either had no effect or was slightly inhibitory to the LH-induced cyclic AMP accumulation, depending on the culture period.	Cyclic AMP	103-113	interleukin 1 alpha	Homo sapiens	26-36
1931864-3	1991	In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1.	Alginates	47-56	interleukin 1 alpha	Homo sapiens	166-179
1907306-4	1991	We found that most clones from both the peripheral blood and CSF express IL-1, IL-2, IL-4, IFN-gamma, or TNF-alpha cytokine mRNA after activation with ionomycin and PMA.	Ionomycin	151-160	interleukin 1 alpha	Homo sapiens	73-77
14731549-4	1991	This article proposes that oxygen radicals act as second messengers for a variety of agents, including the immunomodulatory cytokines TNF and IL-1, in at least one type of regulatory pathway activating NF-kappa B.	Reactive Oxygen Species	27-42	interleukin 1 alpha	Homo sapiens	142-146
1785374-3	1991	Recombinant human IL-1 alpha (rhIL-1 alpha) stimulated PGE2 and PLA2 release in a time- and dose-dependent manner.	Dinoprostone	55-59	interleukin 1 alpha	Homo sapiens	18-28
1906891-0	1991	Interleukin-1 alpha stimulates prostaglandin biosynthesis in serum-activated mesangial cells by induction of a non-pancreatic (type II) phospholipase A2.	Prostaglandins	31-44	interleukin 1 alpha	Homo sapiens	0-19
1906891-1	1991	Enhanced prostaglandin (PG) biosynthesis is a hallmark of inflammation, and interleukin-1 (IL), a proinflammatory cytokine, is a potent stimulus of PG production.	Prostaglandins	148-150	interleukin 1 alpha	Homo sapiens	76-94
1906891-2	1991	We investigated the mechanisms of IL-1 alpha-enhanced PG synthesis in serum-stimulated mesangial cells.	Prostaglandins	54-56	interleukin 1 alpha	Homo sapiens	34-44
1906891-8	1991	Thus IL-1 directly stimulates, as well as primes cells for, enhanced PG synthesis, in part, by increasing PLA2 activity through new synthesis of a non-pancreatic (Type II) PLA2.	Prostaglandins	69-71	interleukin 1 alpha	Homo sapiens	5-9
2066564-7	1991	The numbers of IL-1-produced colonies resulting from IL-1-producing monocytes could be completely abolished by incorporation of rabbit anti-human IL-1 in the semisolid agarose but not by rabbit anti-human IL-6 or anti-human TNF-alpha.	Sepharose	168-175	interleukin 1 alpha	Homo sapiens	15-19
1852623-0	1991	Dinucleotide repeat polymorphism in the human interleukin 1, alpha gene (IL1A).	Dinucleoside Phosphates	0-12	interleukin 1 alpha	Homo sapiens	46-66
1852623-0	1991	Dinucleotide repeat polymorphism in the human interleukin 1, alpha gene (IL1A).	Dinucleoside Phosphates	0-12	interleukin 1 alpha	Homo sapiens	73-77
2066564-7	1991	The numbers of IL-1-produced colonies resulting from IL-1-producing monocytes could be completely abolished by incorporation of rabbit anti-human IL-1 in the semisolid agarose but not by rabbit anti-human IL-6 or anti-human TNF-alpha.	Sepharose	168-175	interleukin 1 alpha	Homo sapiens	53-57
1872130-0	1991	Human recombinant interleukin 1 inhibits TSH-stimulated morphological changes in thyroid follicles cultured as semi-organs.	Thyrotropin	41-44	interleukin 1 alpha	Homo sapiens	18-31
2066564-7	1991	The numbers of IL-1-produced colonies resulting from IL-1-producing monocytes could be completely abolished by incorporation of rabbit anti-human IL-1 in the semisolid agarose but not by rabbit anti-human IL-6 or anti-human TNF-alpha.	Sepharose	168-175	interleukin 1 alpha	Homo sapiens	53-57
1872130-6	1991	On the other hand, both IL-1 alpha and beta inhibited these TSH-stimulated changes.	Thyrotropin	60-63	interleukin 1 alpha	Homo sapiens	24-34
1872130-8	1991	We conclude that IL-1 inhibits TSH-stimulated morphological changes in thyroid follicles cultured as semi-organs, depending on the concentration of IL-1.	Thyrotropin	31-34	interleukin 1 alpha	Homo sapiens	17-21
1914496-3	1991	Gamma Interferon (gamma-IFN), Tumor Necrosis Factor (TNF), and Interleukin 1 (IL1) are peptide regulatory factors involved in immunological responses, but they also play a role in the synthesis of collagen and prostaglandin E2 by fibroblasts.	Dinoprostone	210-226	interleukin 1 alpha	Homo sapiens	63-76
1872130-8	1991	We conclude that IL-1 inhibits TSH-stimulated morphological changes in thyroid follicles cultured as semi-organs, depending on the concentration of IL-1.	Thyrotropin	31-34	interleukin 1 alpha	Homo sapiens	148-152
1853890-8	1991	In addition to stimulation of prostaglandin biosynthesis and labor, the placental interleukin-1 may act as an inflammatory mediator, leading to systemic and local changes at fetomaternal interface and activating fetomaternal immune systems against intrauterine infection.	Prostaglandins	30-43	interleukin 1 alpha	Homo sapiens	82-95
1751203-7	1991	A parallel in vitro study showed that IL-1 produced during HD requires at least 24 hours to be released, and that both CU and PS are able to bind and clear IL-1.	cuprammonium cellulose	119-121	interleukin 1 alpha	Homo sapiens	156-160
1751203-7	1991	A parallel in vitro study showed that IL-1 produced during HD requires at least 24 hours to be released, and that both CU and PS are able to bind and clear IL-1.	polysulfone P 1700	126-128	interleukin 1 alpha	Homo sapiens	156-160
1914496-3	1991	Gamma Interferon (gamma-IFN), Tumor Necrosis Factor (TNF), and Interleukin 1 (IL1) are peptide regulatory factors involved in immunological responses, but they also play a role in the synthesis of collagen and prostaglandin E2 by fibroblasts.	Dinoprostone	210-226	interleukin 1 alpha	Homo sapiens	78-81
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	phorbol-12-myristate	14-34	interleukin 1 alpha	Homo sapiens	290-309
1787777-4	1991	Treatment with levodopa induced an increase in interleukin-1 synthesis, and in IgM and IgA levels in plasma, which suggest a possible selective action on cells of the immune system.	Levodopa	15-23	interleukin 1 alpha	Homo sapiens	47-60
1904900-11	1991	The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells.	Oxygen	163-165	interleukin 1 alpha	Homo sapiens	108-112
1905331-6	1991	Hydrocortisone decreased the expression of both IL-1 alpha and TGF alpha mRNA in keratinocytes.	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	48-58
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	13-acetate	36-46	interleukin 1 alpha	Homo sapiens	290-309
2053589-3	1991	Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells.	Sulfur-35	39-42	interleukin 1 alpha	Homo sapiens	107-117
2054193-9	1991	Budesonide inhibited both spontaneous and interleukin-1 (IL-1)-induced GM-CSF production by cultured HBEC.	Budesonide	0-10	interleukin 1 alpha	Homo sapiens	42-61
2053589-3	1991	Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells.	Sulfur-35	39-42	interleukin 1 alpha	Homo sapiens	107-111
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	Tetradecanoylphorbol Acetate	48-51	interleukin 1 alpha	Homo sapiens	290-309
2053915-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) induced a time-dependent (0-72 hours) and concentration-dependent (0.01-10 ng/ml) production of metalloproteinases (collagenase, gelatinase, stromelysin) and prostaglandin E2 (PGE2) in rabbit articular chondrocytes (RAC).	Dinoprostone	209-225	interleukin 1 alpha	Homo sapiens	18-37
2053915-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) induced a time-dependent (0-72 hours) and concentration-dependent (0.01-10 ng/ml) production of metalloproteinases (collagenase, gelatinase, stromelysin) and prostaglandin E2 (PGE2) in rabbit articular chondrocytes (RAC).	Dinoprostone	209-225	interleukin 1 alpha	Homo sapiens	39-49
1710149-3	1991	However, the addition of IL-1 alpha to CD34+ DR+ cultures containing IL-6 resulted in the appearance of CFU-MK-derived colonies, suggesting that IL-6 requires the presence of IL-1 alpha to exhibit its MK colony-stimulating activity (MK-CSA).	mk-csa	233-239	interleukin 1 alpha	Homo sapiens	25-35
2053915-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) induced a time-dependent (0-72 hours) and concentration-dependent (0.01-10 ng/ml) production of metalloproteinases (collagenase, gelatinase, stromelysin) and prostaglandin E2 (PGE2) in rabbit articular chondrocytes (RAC).	Dinoprostone	227-231	interleukin 1 alpha	Homo sapiens	18-37
1710149-5	1991	The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination.	mk-csa	143-149	interleukin 1 alpha	Homo sapiens	39-49
2053915-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) induced a time-dependent (0-72 hours) and concentration-dependent (0.01-10 ng/ml) production of metalloproteinases (collagenase, gelatinase, stromelysin) and prostaglandin E2 (PGE2) in rabbit articular chondrocytes (RAC).	Dinoprostone	227-231	interleukin 1 alpha	Homo sapiens	39-49
1710149-5	1991	The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination.	mk-csa	143-149	interleukin 1 alpha	Homo sapiens	110-120
2053915-2	1991	Exposure of RAC to recombinant human platelet-derived growth factor homodimer BB (PDGF-BB; 2-200 ng/ml) in the presence of stimulatory and substimulatory concentrations of IL-1 alpha resulted in a marked augmentation of metalloproteinase and PGE2 production.	Dinoprostone	242-246	interleukin 1 alpha	Homo sapiens	172-182
1710149-5	1991	The addition of either anti-IL-6, anti-IL-1 alpha, or anti-IL-3 antisera to cultures containing both IL-6 and IL-1 alpha totally abolished the MK-CSA of the IL-6/IL-1 alpha combination.	mk-csa	143-149	interleukin 1 alpha	Homo sapiens	110-120
2053915-5	1991	Cycloheximide and actinomycin D caused a concentration-dependent suppression of the PDGF-BB-mediated potentiation of radiolabeled IL-1 alpha binding to RAC and cell responsiveness to IL-1 alpha.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	130-140
1884096-2	1991	Strips of rabbit superior mesenteric artery, precontracted with phenylephrine, relaxed when exposed to human recombinant interleukin-1 (IL-1) of the alpha or beta types.	Phenylephrine	64-77	interleukin 1 alpha	Homo sapiens	121-134
2053915-5	1991	Cycloheximide and actinomycin D caused a concentration-dependent suppression of the PDGF-BB-mediated potentiation of radiolabeled IL-1 alpha binding to RAC and cell responsiveness to IL-1 alpha.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	183-193
1884096-2	1991	Strips of rabbit superior mesenteric artery, precontracted with phenylephrine, relaxed when exposed to human recombinant interleukin-1 (IL-1) of the alpha or beta types.	Phenylephrine	64-77	interleukin 1 alpha	Homo sapiens	136-140
2053915-5	1991	Cycloheximide and actinomycin D caused a concentration-dependent suppression of the PDGF-BB-mediated potentiation of radiolabeled IL-1 alpha binding to RAC and cell responsiveness to IL-1 alpha.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	130-140
1884096-9	1991	Indomethacin (2.8 microM) prevented or acutely reversed IL-1-induced relaxations in the rabbit mesenteric artery.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	56-60
2053915-5	1991	Cycloheximide and actinomycin D caused a concentration-dependent suppression of the PDGF-BB-mediated potentiation of radiolabeled IL-1 alpha binding to RAC and cell responsiveness to IL-1 alpha.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	183-193
1914415-0	1991	Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells.	hyaluronate	27-38	interleukin 1 alpha	Homo sapiens	10-23
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	hyaluronate	52-63	interleukin 1 alpha	Homo sapiens	0-13
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	hyaluronate	52-63	interleukin 1 alpha	Homo sapiens	15-19
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	ha	65-67	interleukin 1 alpha	Homo sapiens	0-13
1914415-1	1991	Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro.	ha	65-67	interleukin 1 alpha	Homo sapiens	15-19
1713772-1	1991	Full-length vascular cell adhesion molecule-1 (VCAM-1) cDNA cloned by polymerase chain reaction (PCR) of poly(A)+RNA from interleukin-1 (IL-1)-activated human umbilical vein endothelial cells (HUVEC) contained an insert of 276 nucleotides after position 1,034 of the previously published sequence.	Poly A	105-112	interleukin 1 alpha	Homo sapiens	122-141
1715762-0	1991	Role of calcium on interleukin-1 production by monocytes: its relevance during T cell proliferation.	Calcium	8-15	interleukin 1 alpha	Homo sapiens	19-32
2033250-8	1991	However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29.	Okadaic Acid	75-87	interleukin 1 alpha	Homo sapiens	183-187
2033250-8	1991	However, when cultures were treated with the protein phosphatase inhibitor okadaic acid alone, the level of pP29 increased after 1 h and the presence of okadaic acid during prolonged IL-1 treatment blocked the decline in pP29.	Okadaic Acid	153-165	interleukin 1 alpha	Homo sapiens	183-187
2033250-9	1991	The protein synthesis inhibitors puromycin, emetine, and cycloheximide also blocked the decline in pP29 during IL-1 treatment.	Puromycin	33-42	interleukin 1 alpha	Homo sapiens	111-115
2033250-9	1991	The protein synthesis inhibitors puromycin, emetine, and cycloheximide also blocked the decline in pP29 during IL-1 treatment.	Emetine	44-51	interleukin 1 alpha	Homo sapiens	111-115
2033250-9	1991	The protein synthesis inhibitors puromycin, emetine, and cycloheximide also blocked the decline in pP29 during IL-1 treatment.	Cycloheximide	57-70	interleukin 1 alpha	Homo sapiens	111-115
1653038-0	1991	In situ hybridization for the detection of feline interleukin 1 alpha mRNA on the paraffin-embedded section using biotin-labeled probes.	Paraffin	82-90	interleukin 1 alpha	Homo sapiens	50-69
1653038-0	1991	In situ hybridization for the detection of feline interleukin 1 alpha mRNA on the paraffin-embedded section using biotin-labeled probes.	Biotin	114-120	interleukin 1 alpha	Homo sapiens	50-69
1653038-1	1991	In situ hybridization (ISH) technique with a biotin-labeled probe was established for detecting feline interleukin 1 (IL-1) alpha mRNA in necropsied specimens.	Biotin	45-51	interleukin 1 alpha	Homo sapiens	103-116
1653038-1	1991	In situ hybridization (ISH) technique with a biotin-labeled probe was established for detecting feline interleukin 1 (IL-1) alpha mRNA in necropsied specimens.	Biotin	45-51	interleukin 1 alpha	Homo sapiens	118-129
1653038-2	1991	Homology between human IL-1 alpha cDNA used as a probe and feline IL-1 alpha mRNA was confirmed by means of dot blot hybridization using the biotin-labeled probe.	Biotin	141-147	interleukin 1 alpha	Homo sapiens	23-33
1653038-2	1991	Homology between human IL-1 alpha cDNA used as a probe and feline IL-1 alpha mRNA was confirmed by means of dot blot hybridization using the biotin-labeled probe.	Biotin	141-147	interleukin 1 alpha	Homo sapiens	66-76
1653038-3	1991	Hence, we tried by this biotinylated probe to detect mRNA of IL-1 alpha in paraffin-embedded sections.	Paraffin	75-83	interleukin 1 alpha	Homo sapiens	61-71
1827818-4	1991	We have found that this cytokine is an autocrine growth factor, because proliferation of Th2 cells in response to several stimuli is inhibited by anti-IL-1 alpha or anti-IL-1R mAb, or by an IL-1 alpha antisense oligodeoxynucleotide.	Oligodeoxyribonucleotides	211-231	interleukin 1 alpha	Homo sapiens	190-200
1868042-3	1991	The cytotoxic effects of rIL-1 beta beta were blocked by the simultaneous presence of a naturally occurring 6-9-kilodalton (kDa) inhibitor of IL-1-induced T-cell proliferation.	6-9-kilodalton	108-122	interleukin 1 alpha	Homo sapiens	26-30
1715762-4	1991	On the other hand, IL-1 production by LPS-stimulated monocytes was strongly decreased both by EGTA and nifedipin.	Egtazic Acid	94-98	interleukin 1 alpha	Homo sapiens	19-23
1715762-4	1991	On the other hand, IL-1 production by LPS-stimulated monocytes was strongly decreased both by EGTA and nifedipin.	Nifedipine	103-112	interleukin 1 alpha	Homo sapiens	19-23
1715762-5	1991	Northern blot analysis showed that this inhibition paralleled a decrease of IL-1 alpha and beta messenger RNA (mRNA) expression only in the presence of EGTA but not in the presence of nifedipin.	Egtazic Acid	152-156	interleukin 1 alpha	Homo sapiens	76-86
1715762-7	1991	Thus, it is suggested that the impairment of T cell proliferation by calcium inhibitors could result not only from an effect on Ca2+ influx in T cells but also from interfering with the function of accessory cells, such as the production of IL-1.	Calcium	69-76	interleukin 1 alpha	Homo sapiens	241-245
2039486-0	1991	1,25(OH)2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production.	Calcitriol	0-12	interleukin 1 alpha	Homo sapiens	38-51
2031055-8	1991	In addition, combining IL-1 with dexamethasone, a synthetic glucocorticoid that enhances some IL-1 actions, produced only additive, not synergistic, increases in Cu-Zn SOD activities.	Dexamethasone	33-46	interleukin 1 alpha	Homo sapiens	94-98
2047762-1	1991	The production and mRNA expression of IL-1 alpha and IL-1 beta by human monocytes was examined after two different stimuli, a protein kinase C (PKC) activator phorbol myristate acetate (PMA) and bacterial lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	159-184	interleukin 1 alpha	Homo sapiens	38-48
2047762-1	1991	The production and mRNA expression of IL-1 alpha and IL-1 beta by human monocytes was examined after two different stimuli, a protein kinase C (PKC) activator phorbol myristate acetate (PMA) and bacterial lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	186-189	interleukin 1 alpha	Homo sapiens	38-48
2039486-3	1991	We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells.	1,25(oh)2-cholecalciferol	65-90	interleukin 1 alpha	Homo sapiens	113-117
2039486-3	1991	We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells.	Calcitriol	92-104	interleukin 1 alpha	Homo sapiens	113-117
2039486-4	1991	1,25(OH)2-D3 inhibited the IL-1-alpha induced IL-8 production and mRNA expression in keratinocytes, fibroblasts and PBMC, but not in endothelial cells.	Calcitriol	0-12	interleukin 1 alpha	Homo sapiens	27-37
2025958-0	1991	Synergistic effect of coumarin (1,2 benzopyrone) and endotoxin in the induction of human interleukin-1.	coumarin	22-30	interleukin 1 alpha	Homo sapiens	89-102
1826880-2	1991	Recent radioligand binding studies have identified high-affinity binding sites for 125I-recombinant human IL-1 alpha in the hippocampus with characteristics similar to those of IL-1 receptors in immune cells.	Iodine-125	83-87	interleukin 1 alpha	Homo sapiens	106-116
2025651-3	1991	The reduction in LPL activity was most prominent in the heparin releasable pool; IL-1 treatment resulted in a 7.2-8.3-fold decrease in the functional compartment and a 2.5-2.8-fold decrease in residual cellular activity.	Heparin	56-63	interleukin 1 alpha	Homo sapiens	81-85
1826853-6	1991	The fact that Dex treatment also reduced the level of circulating M-CSF after rhuIL-1 administration suggests that the inhibitory effects of IL-1 are mediated through locally produced M-CSF.	Dexamethasone	14-17	interleukin 1 alpha	Homo sapiens	81-85
2025958-0	1991	Synergistic effect of coumarin (1,2 benzopyrone) and endotoxin in the induction of human interleukin-1.	coumarin	32-47	interleukin 1 alpha	Homo sapiens	89-102
2022165-6	1991	The addition of prednisolone to cell cultures suppressed prostaglandin E2, interleukin-1 synthesis, and monocyte zinc did not change.	Prednisolone	16-28	interleukin 1 alpha	Homo sapiens	75-88
2016326-3	1991	Treatment of exponentially growing MRC5 cells with these cytokines led to a 3-4-fold increase in transferrin receptor mRNA and a coordinate increase in transferrin receptor protein by 24 h. Under these conditions, stimulation of [3H]thymidine incorporation was minimal, suggesting that the induction of transferrin receptor by TNF and IL-1 is mediated by a growth-independent regulatory mechanism.	Tritium	230-232	interleukin 1 alpha	Homo sapiens	335-339
1840657-0	1991	Construction of interleukin-1 alpha mutants using unequal contamination of synthetic oligonucleotides.	Oligonucleotides	85-101	interleukin 1 alpha	Homo sapiens	16-35
1840657-4	1991	Using double-stranded cassettes, a region of the human interleukin-1 alpha gene has been altered using such mutagenic oligonucleotides.	Oligonucleotides	118-134	interleukin 1 alpha	Homo sapiens	55-74
2016326-3	1991	Treatment of exponentially growing MRC5 cells with these cytokines led to a 3-4-fold increase in transferrin receptor mRNA and a coordinate increase in transferrin receptor protein by 24 h. Under these conditions, stimulation of [3H]thymidine incorporation was minimal, suggesting that the induction of transferrin receptor by TNF and IL-1 is mediated by a growth-independent regulatory mechanism.	Thymidine	233-242	interleukin 1 alpha	Homo sapiens	335-339
1855144-3	1991	Moreover, we also show that after the administration of interleukin-1 alpha, tumor necrosis factor-alpha, and corticotropin releasing hormone, naloxone becomes analgesic itself.	Naloxone	143-151	interleukin 1 alpha	Homo sapiens	56-104
2016326-9	1991	This study demonstrates that the complex role of TNF and IL-1 in iron homeostasis includes modulation of the transferrin receptor.	Iron	65-69	interleukin 1 alpha	Homo sapiens	57-61
1864286-6	1991	However, most other functions such as IL-1 and TNF production, and proliferation of lymphocytes and bone marrow progenitor cells are inhibited in vitro by concentrations of quinolones exceeding 50 micrograms/ml.	Quinolones	173-183	interleukin 1 alpha	Homo sapiens	38-42
1860049-6	1991	I0(IL-1) was sensitive to changes in the external Na+ concentration but not to changes in K+, Ca2+ and Cl- concentrations, and was resistant to tetraethylammonium (5 mM) and 4-aminopyridine (5 mM).	Tetraethylammonium	144-162	interleukin 1 alpha	Homo sapiens	3-7
1860049-6	1991	I0(IL-1) was sensitive to changes in the external Na+ concentration but not to changes in K+, Ca2+ and Cl- concentrations, and was resistant to tetraethylammonium (5 mM) and 4-aminopyridine (5 mM).	4-Aminopyridine	174-189	interleukin 1 alpha	Homo sapiens	3-7
1860049-8	1991	I0(IL-1) was partially reduced by 50 microM ouabain.	Ouabain	44-51	interleukin 1 alpha	Homo sapiens	3-7
1825935-9	1991	IL-1 stimulates prostaglandin E2 release by NIH:OVCAR-3 cells, but this response is unrelated to the antiproliferative effect of IL-1.	Dinoprostone	16-32	interleukin 1 alpha	Homo sapiens	0-4
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	odn	31-34	interleukin 1 alpha	Homo sapiens	109-148
1645326-0	1991	Human immunoglobulin preparation for intravenous use induces elevation of cellular cyclic adenosine 3":5"-monophosphate levels, resulting in suppression of tumour necrosis factor alpha and interleukin-1 production.	cyclic adenosine 3":	83-103	interleukin 1 alpha	Homo sapiens	189-202
1645326-0	1991	Human immunoglobulin preparation for intravenous use induces elevation of cellular cyclic adenosine 3":5"-monophosphate levels, resulting in suppression of tumour necrosis factor alpha and interleukin-1 production.	5"-monophosphate	103-119	interleukin 1 alpha	Homo sapiens	189-202
1645326-6	1991	N6, 2"-0-dibutyryl cAMP (BtcAMP), a lipid-soluble derivative of cAMP, and cholera toxin (CT), an adenylate cyclase activating agent, also suppressed the production of TNF-alpha and IL-1.	n6, 2"-0-dibutyryl	0-18	interleukin 1 alpha	Homo sapiens	181-185
1645326-6	1991	N6, 2"-0-dibutyryl cAMP (BtcAMP), a lipid-soluble derivative of cAMP, and cholera toxin (CT), an adenylate cyclase activating agent, also suppressed the production of TNF-alpha and IL-1.	btcamp	25-31	interleukin 1 alpha	Homo sapiens	181-185
2007786-6	1991	Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC.	Hydrocortisone	12-26	interleukin 1 alpha	Homo sapiens	122-126
2007786-6	1991	Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC.	Prednisolone	28-40	interleukin 1 alpha	Homo sapiens	122-126
2007786-6	1991	Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC.	Dexamethasone	45-58	interleukin 1 alpha	Homo sapiens	122-126
1645326-8	1991	These results indicate that the binding of IGIV to PEC via Fc gamma receptors (Fc gamma R) induces the elevation of intracellular cAMP levels, resulting in the suppression of LPS-induced TNF-alpha and IL-1 productions.	Cyclic AMP	130-134	interleukin 1 alpha	Homo sapiens	201-205
1831388-3	1991	Molecular exclusion column chromatography with Sephacryl S-300 HR revealed that 125I-labeled IL-1 alpha added to normal human serum rapidly formed higher molecular weight complexes without indication of proteolytic degradation.	sephacryl s	47-58	interleukin 1 alpha	Homo sapiens	93-103
1831388-7	1991	Kinetic analysis with 125I-labeled IL-1 alpha revealed that the average binding affinity of these IL-1 alpha-specific IgGs was 4.7 x 10(10) M-1.	Iodine-125	22-26	interleukin 1 alpha	Homo sapiens	35-45
1831388-7	1991	Kinetic analysis with 125I-labeled IL-1 alpha revealed that the average binding affinity of these IL-1 alpha-specific IgGs was 4.7 x 10(10) M-1.	Iodine-125	22-26	interleukin 1 alpha	Homo sapiens	98-108
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	Diazepam	35-43	interleukin 1 alpha	Homo sapiens	109-148
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	Benzodiazepines	67-82	interleukin 1 alpha	Homo sapiens	109-148
1678655-2	1991	The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes, as determined by specific immunoreactive and biological assays for these cytokines.	Benzodiazepines	73-76	interleukin 1 alpha	Homo sapiens	178-197
1647544-4	1991	Piascledine partially reverses the effect of interleukin-1 on synovial cells and totally abolishes its action on chondrocytes.	piascledine	0-11	interleukin 1 alpha	Homo sapiens	45-58
1647544-5	1991	Moreover, incubation of the two cell types for 5 days with Piascledine prior to a 48 h-exposure to interleukin-1 prevents partially the effect of interleukin-1.	piascledine	59-70	interleukin 1 alpha	Homo sapiens	146-159
1647544-6	1991	These data suggest a potential role for Piascledine to limit the deleterious effects of interleukin-1 in osteoarticular diseases by reducing the capacity of this cytokine to stimulate collagenase production by synoviocytes and chondrocytes.	piascledine	40-51	interleukin 1 alpha	Homo sapiens	88-101
1825941-4	1991	However, the interleukins IL-1 alpha, IL-1 beta, IL-2, and tumour necrosis factor (TNF) alpha and beta, but not IL-6, stimulated neopterin production by unfractionated peripheral blood mononuclear cells (PBMC), and culture supernatants from PBMC stimulated with IL-1 alpha, IL-1 beta, IL-2 and IL-6, but not TNF-alpha or TNF-beta induced neopterin production following transfer to fresh monocyte cultures.	Neopterin	129-138	interleukin 1 alpha	Homo sapiens	26-36
2043214-0	1991	Obligatory action of polypeptide growth factors for the IL-1-mediated prostaglandin E2 production in fibroblasts: potential role of growth factors in modulation of tissue response to IL-1.	Dinoprostone	70-86	interleukin 1 alpha	Homo sapiens	56-60
1900943-0	1991	Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.	Aspirin	0-7	interleukin 1 alpha	Homo sapiens	17-30
1900943-3	1991	Pretreatment with aspirin at low concentrations (0.1-1 micrograms/ml) inhibited more than 60% of the enzyme mass and also the cyclooxygenase activity in IL-1-induced cells with only minimal effects on the basal level of the synthase enzyme in cells without IL-1.	Aspirin	18-25	interleukin 1 alpha	Homo sapiens	153-157
1900943-3	1991	Pretreatment with aspirin at low concentrations (0.1-1 micrograms/ml) inhibited more than 60% of the enzyme mass and also the cyclooxygenase activity in IL-1-induced cells with only minimal effects on the basal level of the synthase enzyme in cells without IL-1.	Aspirin	18-25	interleukin 1 alpha	Homo sapiens	257-261
1900943-5	1991	Similarly low levels of aspirin inhibited the increased L-[35S]methionine incorporation into PGH synthase that was induced by IL-1 and also suppressed expression of the 2.7-kilobase PGH synthase mRNA.	Aspirin	24-31	interleukin 1 alpha	Homo sapiens	126-130
1900943-5	1991	Similarly low levels of aspirin inhibited the increased L-[35S]methionine incorporation into PGH synthase that was induced by IL-1 and also suppressed expression of the 2.7-kilobase PGH synthase mRNA.	L-Methionine-35S	56-73	interleukin 1 alpha	Homo sapiens	126-130
1997187-0	1991	Interleukin 1 alpha blocks estradiol-stimulated growth and down-regulates the estrogen receptor in MCF-7 breast cancer cells in vitro.	Estradiol	27-36	interleukin 1 alpha	Homo sapiens	0-19
1997187-3	1991	Inhibition with trans-hydroxytamoxifen was IL-1 alpha dose dependent (maximum = 97% at 1000 units/ml, P less than 0.01) and estradiol dose dependent (reversible with 10(-8) M estradiol, maximum inhibition at 10(-10) M estradiol).	4'-hydroxytamoxifen	16-38	interleukin 1 alpha	Homo sapiens	43-53
1869367-0	1991	Glyco-tuftsin derivatives modulate interleukin-1 and tumor necrosis factor production.	glyco-tuftsin	0-13	interleukin 1 alpha	Homo sapiens	35-74
1880018-9	1991	This is consistent with the finding that 1,25-(OH)2D3 also inhibited IL-1 alpha, TNF alpha and LT production in these cultures.	Calcitriol	41-53	interleukin 1 alpha	Homo sapiens	69-79
1675281-4	1991	However, when rat femoral head cartilage samples were incubated with 100 ng mL-1 rHu-IL-1 alpha or IL-1 beta for 5 days there was a significant increase in GAG loss from the cartilage into medium, whilst human synovial fluid significantly decreased the loss of GAG from rat cartilage into medium, compared with controls.	Glycosaminoglycans	156-159	interleukin 1 alpha	Homo sapiens	85-95
1675281-4	1991	However, when rat femoral head cartilage samples were incubated with 100 ng mL-1 rHu-IL-1 alpha or IL-1 beta for 5 days there was a significant increase in GAG loss from the cartilage into medium, whilst human synovial fluid significantly decreased the loss of GAG from rat cartilage into medium, compared with controls.	Glycosaminoglycans	261-264	interleukin 1 alpha	Homo sapiens	85-95
2004073-1	1991	A case of hypercalcaemia secondary to a long-standing solitary ameloblastoma is presented with evidence to suggest that the raised plasma calcium was the result of the secretion of interleukin-1 and a parathyroid hormone-like substances by the tumour.	Calcium	138-145	interleukin 1 alpha	Homo sapiens	181-194
1995437-9	1991	These data suggest that tumor necrosis factor-alpha and interleukin-1 alpha are related to some of the metabolic consequences of both acute and chronic alcohol-induced liver disease, whereas interleukin-6 is related to abnormalities seen in acute liver injury.	Alcohols	152-159	interleukin 1 alpha	Homo sapiens	56-75
1703047-0	1991	Effects of an immunosuppressant, FK506, on interleukin 1 alpha production by human macrophages and a macrophage-like cell line, U937.	Tacrolimus	33-38	interleukin 1 alpha	Homo sapiens	43-62
1703047-3	1991	FK506 partially suppressed IL-1 alpha release, from macrophage-like U937 cells stimulated with phorbol myristate acetate and from human monocytes and alveolar macrophages activated with lipopolysaccharide, in a dose-dependent manner.	Tacrolimus	0-5	interleukin 1 alpha	Homo sapiens	27-37
1703047-3	1991	FK506 partially suppressed IL-1 alpha release, from macrophage-like U937 cells stimulated with phorbol myristate acetate and from human monocytes and alveolar macrophages activated with lipopolysaccharide, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 alpha	Homo sapiens	27-37
1703047-4	1991	Moreover, it was indicated that FK506 suppressed not only IL-1 release but also IL-1 synthesis itself, by measurement of cell-associated IL-1 alpha of U937 cells.	Tacrolimus	32-37	interleukin 1 alpha	Homo sapiens	58-62
1703047-4	1991	Moreover, it was indicated that FK506 suppressed not only IL-1 release but also IL-1 synthesis itself, by measurement of cell-associated IL-1 alpha of U937 cells.	Tacrolimus	32-37	interleukin 1 alpha	Homo sapiens	80-84
1703047-4	1991	Moreover, it was indicated that FK506 suppressed not only IL-1 release but also IL-1 synthesis itself, by measurement of cell-associated IL-1 alpha of U937 cells.	Tacrolimus	32-37	interleukin 1 alpha	Homo sapiens	137-147
1703047-5	1991	The optimal concentrations of FK506 for suppressing IL-1 alpha did not affect cell viability or proliferation, and were 10- to 100-fold lower than those of cyclosporin A.	Tacrolimus	30-35	interleukin 1 alpha	Homo sapiens	52-62
1703047-6	1991	It is concluded that FK506 affects macrophage physiology, suppressing IL-1 alpha production significantly.	Tacrolimus	21-26	interleukin 1 alpha	Homo sapiens	70-80
2016118-1	1991	The production of the cytokines tumour necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes was analysed following their stimulation with muramyl dipeptide (MDP; 1 microgram/ml), in the absence or presence of graded concentrations of platelet-activating factor (PAF).	Dipeptides	159-168	interleukin 1 alpha	Homo sapiens	80-84
2027111-2	1991	Piroxicam has been shown to downregulate the expression of interleukin 1 (IL-1) associated chondrocyte enzyme inducing activity (catabolin) produced by OA synovium.	Piroxicam	0-9	interleukin 1 alpha	Homo sapiens	59-78
1991694-0	1991	Interleukin-1 modification of the effects of cyclophosphamide and fractionated irradiation.	Cyclophosphamide	45-61	interleukin 1 alpha	Homo sapiens	0-13
1991694-1	1991	Studies were performed to determine whether recombinant human interleukin-1 (IL-1) modifies the tumor cytotoxicity of cyclophosphamide (CY) combined with fractionated X-irradiation.	Cyclophosphamide	118-134	interleukin 1 alpha	Homo sapiens	62-75
1991694-1	1991	Studies were performed to determine whether recombinant human interleukin-1 (IL-1) modifies the tumor cytotoxicity of cyclophosphamide (CY) combined with fractionated X-irradiation.	Cyclophosphamide	118-134	interleukin 1 alpha	Homo sapiens	77-81
1991694-1	1991	Studies were performed to determine whether recombinant human interleukin-1 (IL-1) modifies the tumor cytotoxicity of cyclophosphamide (CY) combined with fractionated X-irradiation.	Cyclophosphamide	136-138	interleukin 1 alpha	Homo sapiens	62-75
1991694-1	1991	Studies were performed to determine whether recombinant human interleukin-1 (IL-1) modifies the tumor cytotoxicity of cyclophosphamide (CY) combined with fractionated X-irradiation.	Cyclophosphamide	136-138	interleukin 1 alpha	Homo sapiens	77-81
1991694-6	1991	From these findings, it appears that IL-1 enhances the cytotoxic effects of CY and X ray against tumors, an effect that would have considerable practical significance in the light of the protective effects shown elsewhere for the same lymphokine on normal tissues.	Cyclophosphamide	76-78	interleukin 1 alpha	Homo sapiens	37-41
2027111-4	1991	The piroxicam effect appears due to a selective increase in production of a naturally occurring inhibitor(s) and/or induction of new inhibitor formation acting on chondrocytes at a post-IL-1 receptor level.	Piroxicam	4-13	interleukin 1 alpha	Homo sapiens	186-190
1719750-5	1991	An increasing body of evidence indicates that IL-1, IFN-alpha, as well as C3a and C5a of the complement cascade, are capable of acting on central catecholamines within the brain.	Catecholamines	146-160	interleukin 1 alpha	Homo sapiens	46-50
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	Tetradecanoylphorbol Acetate	250-281	interleukin 1 alpha	Homo sapiens	295-308
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	phorbol	250-257	interleukin 1 alpha	Homo sapiens	295-308
1901643-5	1991	We demonstrate that both the AP-1 sequence and the URS bind phorbol or interleukin-1 induced nuclear proteins.	Peptichemio	51-54	interleukin 1 alpha	Homo sapiens	71-84
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	interleukin 1 alpha	Homo sapiens	138-142
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	interleukin 1 alpha	Homo sapiens	138-142
1755377-9	1991	This IL-1/TNF/PMA-activated protein kinase is distinct from protein kinase A, protein kinase C or casein kinase in substrate specificity; in Ca and phospholipid dependency; in cyclic nucleotide dependency; and sensitivity to protein kinase inhibitors.	Phospholipids	148-160	interleukin 1 alpha	Homo sapiens	5-9
1755377-9	1991	This IL-1/TNF/PMA-activated protein kinase is distinct from protein kinase A, protein kinase C or casein kinase in substrate specificity; in Ca and phospholipid dependency; in cyclic nucleotide dependency; and sensitivity to protein kinase inhibitors.	Nucleotides, Cyclic	176-193	interleukin 1 alpha	Homo sapiens	5-9
2069091-3	1991	DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA.	DA-E 5090	0-8	interleukin 1 alpha	Homo sapiens	24-34
2069091-4	1991	Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.	DA-E 5090	42-50	interleukin 1 alpha	Homo sapiens	77-87
2064213-2	1991	Previously, we found that human endometrial stromal cells respond to the action of interleukin-1 (IL-1) with an increase in the production of prostaglandins.	Prostaglandins	142-156	interleukin 1 alpha	Homo sapiens	83-96
1826821-5	1991	Furthermore, these effects were shown to be sensitive to the weak estrogen, phenol red, since the IL-1-induced shifts in G0/G1 and S phases were markedly blunted in its presence.	Phenolsulfonphthalein	76-86	interleukin 1 alpha	Homo sapiens	98-102
2064213-2	1991	Previously, we found that human endometrial stromal cells respond to the action of interleukin-1 (IL-1) with an increase in the production of prostaglandins.	Prostaglandins	142-156	interleukin 1 alpha	Homo sapiens	98-102
1826821-6	1991	In cell proliferation experiments, the IL-1-induced synchronization of MCF-7 cells increased the cytotoxic efficacy of the chemotherapeutic drug, 5-fluorodeoxyuracil.	5-fluorodeoxyuracil	146-165	interleukin 1 alpha	Homo sapiens	39-43
1796815-3	1991	In order to elucidate the role of these cytokines in psoriasis, messenger RNA (mRNA) expression of interleukin-1 (IL-1) and IL-6 in psoriatic epidermis was investigated using biotin-labelled complementary DNA (cDNA) of the cytokines.	Biotin	175-181	interleukin 1 alpha	Homo sapiens	99-119
1826821-7	1991	These data demonstrate that IL-1 by arresting the estrogen-responsive human breast cancer cells, MCF-7, in the G0/G1-phase of the cell cycle can not only directly inhibit the growth of MCF-7 cells, but also increase the efficacy of FUDR.	Floxuridine	232-236	interleukin 1 alpha	Homo sapiens	28-32
1810214-3	1991	In addition, SIRS prevented the IL-1-induced increase in resistance of thymocytes to the lytic action of hydrocortisone.	Hydrocortisone	105-119	interleukin 1 alpha	Homo sapiens	32-36
1824616-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) and recombinant human IL-1 beta stimulate matrix proteoglycan degradation and inhibit glycosaminoglycan synthesis in bovine nasal cartilage explants.	Glycosaminoglycans	137-154	interleukin 1 alpha	Homo sapiens	18-37
1824616-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) and recombinant human IL-1 beta stimulate matrix proteoglycan degradation and inhibit glycosaminoglycan synthesis in bovine nasal cartilage explants.	Glycosaminoglycans	137-154	interleukin 1 alpha	Homo sapiens	39-49
1675963-5	1991	Spontaneous and PHA induced interleukin-1 (IL-1) was enhanced in the presence of Mn2+.	Manganese(2+)	81-85	interleukin 1 alpha	Homo sapiens	16-47
1812993-2	1991	Interleukin-1 is a potent inhibitor of thyroglobulin and cAMP production in human thyroid cells and the inhibitory effect is enhanced by tumor necrosis factor-alpha and interferon-gamma.	Cyclic AMP	57-61	interleukin 1 alpha	Homo sapiens	0-13
1824916-10	1991	SDS/PAGE analysis of internalized IL-1 in Raji cells revealed that the ligand was sequentially processed to trichloroacetic acid-soluble products.	Trichloroacetic Acid	108-128	interleukin 1 alpha	Homo sapiens	34-38
1824916-12	1991	Treatment of Raji cells with the lysosomotropic agent chloroquine inhibited the degradation of IL-1 without having any effect on the amount of intact IL-1 in the intracellular compartments.	Chloroquine	54-65	interleukin 1 alpha	Homo sapiens	95-99
1686972-5	1991	Moreover, the action of cytokines/lymphokines having DP IV susceptible bonds, as IL-1, IL-2 and IL-6, on lymphocyte proliferation, was found to be suppressed by specific inhibitors of DP IV as well as AP-N.	dp	53-55	interleukin 1 alpha	Homo sapiens	81-85
1686972-5	1991	Moreover, the action of cytokines/lymphokines having DP IV susceptible bonds, as IL-1, IL-2 and IL-6, on lymphocyte proliferation, was found to be suppressed by specific inhibitors of DP IV as well as AP-N.	dp	184-186	interleukin 1 alpha	Homo sapiens	81-85
1722107-0	1991	Muramyl tripeptide phosphatidylethanolamine encapsulated in liposomes stimulates monocyte production of tumor necrosis factor and interleukin-1 in vitro.	mifamurtide	0-43	interleukin 1 alpha	Homo sapiens	130-143
1722107-14	1991	Intracellular IL-1 was significantly increased in monocytes incubated with L-MTP-PE.	L-MTP-PE	75-83	interleukin 1 alpha	Homo sapiens	14-18
1892733-0	1991	Interleukin-1 stimulation of arachidonic acid release from human synovial fibroblasts; blockade by inhibitors of protein kinases and protein synthesis.	Arachidonic Acid	29-45	interleukin 1 alpha	Homo sapiens	0-13
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	[3h]arachidonic acid	82-102	interleukin 1 alpha	Homo sapiens	12-16
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	[3h]arachidonic acid	82-102	interleukin 1 alpha	Homo sapiens	18-31
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	Arachidonic Acid	86-102	interleukin 1 alpha	Homo sapiens	12-16
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	Arachidonic Acid	86-102	interleukin 1 alpha	Homo sapiens	18-31
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	Diglycerides	204-218	interleukin 1 alpha	Homo sapiens	12-16
1892733-1	1991	Addition of IL-1 (interleukin-1) to human synovial fibroblasts radiolabelled with [3H]arachidonic acid caused a linear dose-dependent increase in arachidonic acid release and a transient rise in labelled diacylglycerol.	Diglycerides	204-218	interleukin 1 alpha	Homo sapiens	18-31
1892733-2	1991	Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1.	Tetradecanoylphorbol Acetate	28-31	interleukin 1 alpha	Homo sapiens	210-214
1892733-2	1991	Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1.	4-phorbol 12-myristate 13-acetate	32-65	interleukin 1 alpha	Homo sapiens	210-214
1892733-2	1991	Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1.	dic8 (1,2-dioctanoyl-sn-glycerol	70-102	interleukin 1 alpha	Homo sapiens	210-214
1892733-2	1991	Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1.	Arachidonic Acid	119-135	interleukin 1 alpha	Homo sapiens	210-214
1892733-3	1991	When cultures were treated with PMA for 16-24 h to down regulate protein kinase C, the ability of IL-1 to increase arachidonic acid release persisted to the same extent as in nontreated cultures.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 alpha	Homo sapiens	98-102
1892733-3	1991	When cultures were treated with PMA for 16-24 h to down regulate protein kinase C, the ability of IL-1 to increase arachidonic acid release persisted to the same extent as in nontreated cultures.	Arachidonic Acid	115-131	interleukin 1 alpha	Homo sapiens	98-102
1892733-6	1991	IL-1 stimulation of arachidonic acid release was blocked by H-7, H-8 and staurosporine.	Arachidonic Acid	20-36	interleukin 1 alpha	Homo sapiens	0-4
1892733-6	1991	IL-1 stimulation of arachidonic acid release was blocked by H-7, H-8 and staurosporine.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	65-68	interleukin 1 alpha	Homo sapiens	0-4
1892733-6	1991	IL-1 stimulation of arachidonic acid release was blocked by H-7, H-8 and staurosporine.	Staurosporine	73-86	interleukin 1 alpha	Homo sapiens	0-4
1892733-8	1991	Addition of H-7 at various times following IL-1 decreased IL-1 stimulated arachidonic acid release, suggesting that continued protein kinase activity was necessary for IL-1 action.	Arachidonic Acid	74-90	interleukin 1 alpha	Homo sapiens	58-62
1892733-8	1991	Addition of H-7 at various times following IL-1 decreased IL-1 stimulated arachidonic acid release, suggesting that continued protein kinase activity was necessary for IL-1 action.	Arachidonic Acid	74-90	interleukin 1 alpha	Homo sapiens	58-62
1892733-9	1991	Cycloheximide and actinomycin D inhibited the stimulation of arachidonic acid release by IL-1, PMA or DiC8.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	89-93
1892733-9	1991	Cycloheximide and actinomycin D inhibited the stimulation of arachidonic acid release by IL-1, PMA or DiC8.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	89-93
1892733-9	1991	Cycloheximide and actinomycin D inhibited the stimulation of arachidonic acid release by IL-1, PMA or DiC8.	Arachidonic Acid	61-77	interleukin 1 alpha	Homo sapiens	89-93
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Cycloheximide	16-29	interleukin 1 alpha	Homo sapiens	63-67
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Cycloheximide	16-29	interleukin 1 alpha	Homo sapiens	83-87
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Cycloheximide	16-29	interleukin 1 alpha	Homo sapiens	83-87
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Dactinomycin	33-46	interleukin 1 alpha	Homo sapiens	63-67
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Dactinomycin	33-46	interleukin 1 alpha	Homo sapiens	83-87
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Dactinomycin	33-46	interleukin 1 alpha	Homo sapiens	83-87
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Arachidonic Acid	99-115	interleukin 1 alpha	Homo sapiens	83-87
1715770-5	1991	IL-1 simulation of human and murine fibroblasts resulted in release of prostaglandin E2.	Dinoprostone	71-87	interleukin 1 alpha	Homo sapiens	0-4
1892733-10	1991	The addition of cycloheximide or actinomycin D 15-45 min after IL-1 also inhibited IL-1 stimulated arachidonic acid release, indicating that continued protein synthesis was required for IL-1 action.	Arachidonic Acid	99-115	interleukin 1 alpha	Homo sapiens	83-87
1651782-2	1991	Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6).	Dinoprostone	168-184	interleukin 1 alpha	Homo sapiens	6-16
1997401-0	1991	Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3.	Calcitriol	103-127	interleukin 1 alpha	Homo sapiens	14-54
1651782-2	1991	Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6).	Dinoprostone	186-190	interleukin 1 alpha	Homo sapiens	6-16
1651782-5	1991	However, IL-1 alpha or beta induced PGE2 production by human dermal fibroblasts and by human synovial cells was inhibited (in 5/8 experiments) up to 62% by addition of IL-6.	Dinoprostone	36-40	interleukin 1 alpha	Homo sapiens	9-19
1873492-2	1991	IL-1 alpha and beta preparations were standardized in terms of biological activity in the EL-4/CTLL bioassay and, in parallel, employed to stimulate PGE2 secretion in human fibroblasts, mesangial cells (MC), C57B1/6 mouse MC, DBA/2 mouse macrophages and Sprague Dawley rat MC.	Dinoprostone	149-153	interleukin 1 alpha	Homo sapiens	0-10
1809690-3	1991	Endogenously synthesized Il-1 in turn activates PGE release, indicating that the C5b-9 attack initiates an autocrine feedback stimulation.	Prostaglandins E	48-51	interleukin 1 alpha	Homo sapiens	25-29
1702762-0	1991	Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides.	bacteroides lipopolysaccharides	88-119	interleukin 1 alpha	Homo sapiens	13-33
1667651-4	1991	CBD was also shown to decrease the measurable quantity of both IL-1 and TNF.	Cannabidiol	0-3	interleukin 1 alpha	Homo sapiens	63-67
1814847-0	1991	Chlorpromazine protection against interleukin-1 and tumor necrosis factor-mediated activities in vivo.	Chlorpromazine	0-14	interleukin 1 alpha	Homo sapiens	34-73
1783465-8	1991	Blood mononuclear cells from individuals treated with 1,25-(OH)2D3 showed a significantly reduced production of both interleukin-1 alpha (45%) and tumor necrosis factor-alpha (58%) (both measured by ELISA).	Calcitriol	54-66	interleukin 1 alpha	Homo sapiens	117-136
1845871-2	1991	We studied the effects of IL-1 on phosphatidylinositol (PtdIns) metabolism and confirmed reports indicating that IL-1 does not stimulate increased PtdIns turnover; however, we observed the accumulation of PtdIns-4-phosphate (PtdInsP) in response to IL-1.	Phosphatidylinositols	34-54	interleukin 1 alpha	Homo sapiens	26-30
1845871-2	1991	We studied the effects of IL-1 on phosphatidylinositol (PtdIns) metabolism and confirmed reports indicating that IL-1 does not stimulate increased PtdIns turnover; however, we observed the accumulation of PtdIns-4-phosphate (PtdInsP) in response to IL-1.	Phosphatidylinositols	56-62	interleukin 1 alpha	Homo sapiens	26-30
1845871-3	1991	Using a fibroblast membrane preparation, we were able to detect stimulated PtdInsP accumulation within 10 s of IL-1 addition.	phosphatidylinositol 4-phosphate	75-82	interleukin 1 alpha	Homo sapiens	111-115
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Phosphatidylinositols	16-22	interleukin 1 alpha	Homo sapiens	0-4
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Phosphatidylinositols	16-22	interleukin 1 alpha	Homo sapiens	98-102
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Inositol 1,4,5-Trisphosphate	292-319	interleukin 1 alpha	Homo sapiens	0-4
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Inositol 1,4,5-Trisphosphate	292-319	interleukin 1 alpha	Homo sapiens	98-102
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Diglycerides	324-338	interleukin 1 alpha	Homo sapiens	0-4
1845871-9	1991	IL-1-stimulated PtdIns kinase activity represents an important physiological regulatory effect by IL-1 as it could control the synthesis and/or maintenance of phosphorylated derivatives of PtdIns which comprise only a very small pool of substrates for the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol.	Diglycerides	324-338	interleukin 1 alpha	Homo sapiens	98-102
1943441-7	1991	NH4Cl augmented the effects of IL-1 and IL-6.	Ammonium Chloride	0-5	interleukin 1 alpha	Homo sapiens	31-35
1922610-6	1991	A time course study indicated that the ability of PBMC from transplants to release IL-1 alpha and beta promptly decreased following the operation, possibly owing to prednisolone and ciclosporin immunosuppressive therapy.	Prednisolone	165-177	interleukin 1 alpha	Homo sapiens	83-93
1922610-6	1991	A time course study indicated that the ability of PBMC from transplants to release IL-1 alpha and beta promptly decreased following the operation, possibly owing to prednisolone and ciclosporin immunosuppressive therapy.	Cyclosporine	182-193	interleukin 1 alpha	Homo sapiens	83-93
1997611-9	1991	Moreover, the IL-1 alpha and IL-1 beta concentrations correlated with those of Prostaglandin E2 and F2 alpha in AF, measured by RIA.	Dinoprostone	79-95	interleukin 1 alpha	Homo sapiens	14-24
1925068-6	1991	LPS and iron particles, however, were more efficient in stimulating IL-1 production.	Iron	8-12	interleukin 1 alpha	Homo sapiens	68-72
1905023-3	1991	We also include information on the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti-inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism.	Prostaglandins	212-225	interleukin 1 alpha	Homo sapiens	195-208
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 1 alpha	Homo sapiens	100-104
1925068-7	1991	Absence of IL-1 activity was noted in supernatants of monocyte cultures in the presence of dexamethasone.	Dexamethasone	91-104	interleukin 1 alpha	Homo sapiens	11-15
1667554-1	1991	Studies comparing pulmonary responses to crystalline silica (SiO2) and titanium dioxide (0.3 microns diameter, TiO2-F) demonstrated a positive correlation between alveolar macrophage (AM) release of interleukin-1 (IL-1), tumor necrosis factor (TNF) and fibronectin and, pulmonary granuloma formation, inflammation and fibrosis, respectively.	titanium dioxide	71-87	interleukin 1 alpha	Homo sapiens	214-218
1667554-2	1991	AM IL-1 release was associated with the development of pulmonary granulomas after SiO2 exposure.	Silicon Dioxide	82-86	interleukin 1 alpha	Homo sapiens	3-7
2124239-0	1990	Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts.	Sphingosine	0-11	interleukin 1 alpha	Homo sapiens	24-28
2273259-9	1990	Additionally, we evaluated the detection of IL-1 in the presence of mitogens, phorbol ester or calcium ionophore, as well as the determination of IL-1 in serum and PF samples of human and murine origin.	Calcium	95-102	interleukin 1 alpha	Homo sapiens	44-48
2290308-1	1990	We found a dose-dependent inhibition of spontaneous and LPS-induced IL-1 production of isolated human monocytes by methylprednisolone (MP) in vitro.	Methylprednisolone	115-133	interleukin 1 alpha	Homo sapiens	68-72
2290308-1	1990	We found a dose-dependent inhibition of spontaneous and LPS-induced IL-1 production of isolated human monocytes by methylprednisolone (MP) in vitro.	Methylprednisolone	135-137	interleukin 1 alpha	Homo sapiens	68-72
2290308-2	1990	Kinetic studies of spontaneous and LPS-induced IL-1 production of isolated monocytes of 10 normal individuals showed a synchronous circadian rhythm, with its maximum at 4:00 p.m. and its minimum at 4:00 a.m., which is most probably independent of the physiological circadian rhythm of cortisol levels because the IL-1 production was of the same value at the times of maximum and minimum cortisol levels.	Hydrocortisone	285-293	interleukin 1 alpha	Homo sapiens	47-51
2290308-2	1990	Kinetic studies of spontaneous and LPS-induced IL-1 production of isolated monocytes of 10 normal individuals showed a synchronous circadian rhythm, with its maximum at 4:00 p.m. and its minimum at 4:00 a.m., which is most probably independent of the physiological circadian rhythm of cortisol levels because the IL-1 production was of the same value at the times of maximum and minimum cortisol levels.	Hydrocortisone	387-395	interleukin 1 alpha	Homo sapiens	47-51
2124239-0	1990	Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts.	Dinoprostone	38-54	interleukin 1 alpha	Homo sapiens	24-28
2290308-3	1990	In contrast, in a patient with hypercortisolism and a preserved circadian rhythm of cortisol levels, we found the minimum of IL-1 production at 4:00 p.m., 8 hours after the maximum cortisol level was reached.	Hydrocortisone	36-44	interleukin 1 alpha	Homo sapiens	125-129
2290308-3	1990	In contrast, in a patient with hypercortisolism and a preserved circadian rhythm of cortisol levels, we found the minimum of IL-1 production at 4:00 p.m., 8 hours after the maximum cortisol level was reached.	Hydrocortisone	84-92	interleukin 1 alpha	Homo sapiens	125-129
2124239-1	1990	IL-1 stimulates PGE2 production in human fibroblasts by stimulating arachidonic acid (AA) mobilization and cyclooxygenase synthesis.	Dinoprostone	16-20	interleukin 1 alpha	Homo sapiens	0-4
2124239-1	1990	IL-1 stimulates PGE2 production in human fibroblasts by stimulating arachidonic acid (AA) mobilization and cyclooxygenase synthesis.	Arachidonic Acid	68-84	interleukin 1 alpha	Homo sapiens	0-4
2124239-3	1990	To examine the role of protein kinase C (PKC) in IL-1-mediated PGE2 production, we treated cells with PMA, which stimulated PGE2 production suggesting a positive role for PKC activation in the regulation of PGE2 synthesis.	Dinoprostone	63-67	interleukin 1 alpha	Homo sapiens	49-53
2124239-4	1990	Therefore, we tested the effect of sphingosine, a PKC inhibitor, on IL-1-induced PGE2 production.	Dinoprostone	81-85	interleukin 1 alpha	Homo sapiens	68-72
2124239-3	1990	To examine the role of protein kinase C (PKC) in IL-1-mediated PGE2 production, we treated cells with PMA, which stimulated PGE2 production suggesting a positive role for PKC activation in the regulation of PGE2 synthesis.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 alpha	Homo sapiens	49-53
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	14-25	interleukin 1 alpha	Homo sapiens	41-45
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	50-54
2124239-3	1990	To examine the role of protein kinase C (PKC) in IL-1-mediated PGE2 production, we treated cells with PMA, which stimulated PGE2 production suggesting a positive role for PKC activation in the regulation of PGE2 synthesis.	Dinoprostone	124-128	interleukin 1 alpha	Homo sapiens	49-53
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	209-213	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	209-213	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Dinoprostone	209-213	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-6	1990	However, when sphingosine was added with IL-1, or IL-1 was added to sphingosine-pretreated cells, PGE2 production increased severalfold, suggesting that the inhibition of PKC results in enhanced IL-1-mediated PGE2 production; structural analogs of sphingosine did not potentiate the IL-1 effect.	Sphingosine	68-79	interleukin 1 alpha	Homo sapiens	50-54
2124239-7	1990	In cells made deficient in PKC by prolonged exposure to PMA, IL-1-mediated PGE2 production was enhanced compared with normal cells, further suggesting that functional PKC is not required for, and may down-modulate, IL-1-mediated PGE2 production.	Dinoprostone	75-79	interleukin 1 alpha	Homo sapiens	61-65
2124239-7	1990	In cells made deficient in PKC by prolonged exposure to PMA, IL-1-mediated PGE2 production was enhanced compared with normal cells, further suggesting that functional PKC is not required for, and may down-modulate, IL-1-mediated PGE2 production.	Dinoprostone	229-233	interleukin 1 alpha	Homo sapiens	215-219
2124239-8	1990	These findings also suggest that PMA and IL-1 stimulate PGE2 synthesis via fundamentally different pathways.	Dinoprostone	56-60	interleukin 1 alpha	Homo sapiens	41-45
2124239-9	1990	In separate studies on the effect of IL-1 on AA mobilization, we found that IL-1 induced an increase in phospholipase A2 (PLA2) activity and that cycloheximide blocked the increase, suggesting the requirement for new protein synthesis.	Cycloheximide	146-159	interleukin 1 alpha	Homo sapiens	37-41
2124239-10	1990	We also found that the PLA2 activity increased as a result of IL-1 exposure was further stimulated by sphingosine.	Sphingosine	102-113	interleukin 1 alpha	Homo sapiens	62-66
2124239-11	1990	Thus, in addition to its primary effects on the cell, which are likely mediated via PKC, we present evidence suggesting that sphingosine may also play a role in potentiating an IL-1-induced PLA2 activity, resulting in increased availability of AA for conversion to PGE2.	Sphingosine	125-136	interleukin 1 alpha	Homo sapiens	177-181
2124239-11	1990	Thus, in addition to its primary effects on the cell, which are likely mediated via PKC, we present evidence suggesting that sphingosine may also play a role in potentiating an IL-1-induced PLA2 activity, resulting in increased availability of AA for conversion to PGE2.	Dinoprostone	265-269	interleukin 1 alpha	Homo sapiens	177-181
2147937-0	1990	Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production.	Prostaglandins	105-118	interleukin 1 alpha	Homo sapiens	30-34
2147937-0	1990	Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production.	Prostaglandins	105-118	interleukin 1 alpha	Homo sapiens	77-81
2147937-8	1990	The inhibitory effects appeared to be competitive, because increasing concentrations of IL-1 overcame the block of bone resorption in both systems and the inhibition of PGE2 production in calvariae.	Dinoprostone	169-173	interleukin 1 alpha	Homo sapiens	88-92
2258610-0	1990	Chemoprotective effects of recombinant human IL-1 alpha in cyclophosphamide-treated normal and tumor-bearing mice.	Cyclophosphamide	59-75	interleukin 1 alpha	Homo sapiens	45-55
2258610-2	1990	In this study, recombinant human IL-1 alpha (rhIL-1 alpha) was used to protect normal and tumor-bearing BALB/c mice from the acute toxicity caused by lethal doses of cyclophosphamide (Cy) and 5-fluorouracil.	Cyclophosphamide	166-182	interleukin 1 alpha	Homo sapiens	33-43
2258610-2	1990	In this study, recombinant human IL-1 alpha (rhIL-1 alpha) was used to protect normal and tumor-bearing BALB/c mice from the acute toxicity caused by lethal doses of cyclophosphamide (Cy) and 5-fluorouracil.	Cyclophosphamide	184-186	interleukin 1 alpha	Homo sapiens	33-43
2258610-2	1990	In this study, recombinant human IL-1 alpha (rhIL-1 alpha) was used to protect normal and tumor-bearing BALB/c mice from the acute toxicity caused by lethal doses of cyclophosphamide (Cy) and 5-fluorouracil.	Fluorouracil	192-206	interleukin 1 alpha	Homo sapiens	33-43
2175610-1	1990	Interleukin-1 (IL-1) has been shown to regulate glycosaminoglycan (GAG) synthesis.	Glycosaminoglycans	48-65	interleukin 1 alpha	Homo sapiens	15-19
2175610-1	1990	Interleukin-1 (IL-1) has been shown to regulate glycosaminoglycan (GAG) synthesis.	Glycosaminoglycans	67-70	interleukin 1 alpha	Homo sapiens	0-13
2175610-1	1990	Interleukin-1 (IL-1) has been shown to regulate glycosaminoglycan (GAG) synthesis.	Glycosaminoglycans	67-70	interleukin 1 alpha	Homo sapiens	15-19
2175610-4	1990	Similarly, the decrease in sulfated GAG synthesis induced by IL-1 was reversed by the addition of the IL-1 inhibitor.	Glycosaminoglycans	36-39	interleukin 1 alpha	Homo sapiens	61-65
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	70-74	interleukin 1 alpha	Homo sapiens	0-4
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	70-74	interleukin 1 alpha	Homo sapiens	131-135
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	109-113	interleukin 1 alpha	Homo sapiens	0-4
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	109-113	interleukin 1 alpha	Homo sapiens	131-135
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	109-113	interleukin 1 alpha	Homo sapiens	0-4
1963325-7	1990	IL-1 also inhibited induction of aromatase activity and LH-stimulated cAMP accumulation induced by dibutyryl cAMP, suggesting that IL-1 also affects the steps distal to cAMP generation.	Cyclic AMP	109-113	interleukin 1 alpha	Homo sapiens	131-135
2121579-6	1990	Indomethacin (1, 5, and 10 mg/kg, IP, -30 minutes) induced a dose-related prevention of the inhibitory effect of IC interleukin-1 beta.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	116-129
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Cyclic AMP	4-8	interleukin 1 alpha	Homo sapiens	82-86
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Cyclic AMP	4-8	interleukin 1 alpha	Homo sapiens	151-155
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Colforsin	18-27	interleukin 1 alpha	Homo sapiens	82-86
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Colforsin	18-27	interleukin 1 alpha	Homo sapiens	151-155
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	1-Methyl-3-isobutylxanthine	29-56	interleukin 1 alpha	Homo sapiens	82-86
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	1-Methyl-3-isobutylxanthine	29-56	interleukin 1 alpha	Homo sapiens	151-155
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Dinoprostone	62-66	interleukin 1 alpha	Homo sapiens	82-86
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Dinoprostone	62-66	interleukin 1 alpha	Homo sapiens	151-155
2174073-5	1990	The cAMP agonists forskolin, 3-isobutyl-1-methylxanthine, and PGE2 suppressed the IL-1 induction of stromelysin; conversely, indomethacin superinduced IL-1-elicited stromelysin mRNA.	Indomethacin	125-137	interleukin 1 alpha	Homo sapiens	151-155
2174073-7	1990	2",5"-Dideoxyadenosine, an inhibitor of adenylate cyclase, also augmented the IL-1 induction of stromeylsin mRNA, as did H-8, a specific inhibitor of the cAMP-dependent protein kinase A.	2',5'-dideoxyadenosine	0-22	interleukin 1 alpha	Homo sapiens	78-82
2174073-8	1990	Staurosporine and H-7, inhibitors of protein kinase C, blocked the IL-1 induction of stromelysin mRNA.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	67-71
2127434-2	1990	Intradialytic induction of IL-1 is associated with complement activation in patients dialyzed with first-use cellulose membranes.	Cellulose	109-118	interleukin 1 alpha	Homo sapiens	27-31
2127434-14	1990	An IL-1-inducing activity was, however, detected in the blood compartment upon dialysis with high permeability membranes, as previously found by others with cuprophan membranes.	cuprammonium cellulose	157-166	interleukin 1 alpha	Homo sapiens	3-7
2287944-5	1990	The inhibition of interleukin-1 (IL-1) activity or other inflammatory cytokines by MTX may play an important role in the antiinflammatory effect of MTX.	Methotrexate	83-86	interleukin 1 alpha	Homo sapiens	33-37
2287944-5	1990	The inhibition of interleukin-1 (IL-1) activity or other inflammatory cytokines by MTX may play an important role in the antiinflammatory effect of MTX.	Methotrexate	148-151	interleukin 1 alpha	Homo sapiens	33-37
2287944-7	1990	MTX has crucial effects on the cascade of events initiated by some cytokines (IL-1, IL-6, tumor necrosis factor), which plays a major role in RA and other inflammatory diseases.	Methotrexate	0-3	interleukin 1 alpha	Homo sapiens	78-82
1995225-6	1991	Prednisolone in the culture medium at physiologic concentrations suppressed the release of IL-1 and enhanced the release of IL-1 IHA.	Prednisolone	0-12	interleukin 1 alpha	Homo sapiens	91-95
1995225-6	1991	Prednisolone in the culture medium at physiologic concentrations suppressed the release of IL-1 and enhanced the release of IL-1 IHA.	Prednisolone	0-12	interleukin 1 alpha	Homo sapiens	124-128
2124488-1	1990	Prostaglandin production and cAMP formation are two signaling pathways identified for IL-1, though neither adequately account for the multitude of effects of IL-1.	Prostaglandins	0-13	interleukin 1 alpha	Homo sapiens	86-90
2124488-1	1990	Prostaglandin production and cAMP formation are two signaling pathways identified for IL-1, though neither adequately account for the multitude of effects of IL-1.	Cyclic AMP	29-33	interleukin 1 alpha	Homo sapiens	86-90
2124488-2	1990	To investigate the role of tyrosine phosphorylation in IL-1 signaling, we used the tyrosine kinase inhibitor, genistein.	Tyrosine	27-35	interleukin 1 alpha	Homo sapiens	55-59
2124488-2	1990	To investigate the role of tyrosine phosphorylation in IL-1 signaling, we used the tyrosine kinase inhibitor, genistein.	Genistein	110-119	interleukin 1 alpha	Homo sapiens	55-59
2124488-3	1990	At 10-30 micrograms/ml, genistein blocked IL-1 stimulated prostaglandin production and induction of prostaglandin endoperoxide synthase (PES) in glomerular mesangial cells maintained in 10% serum.	Genistein	24-33	interleukin 1 alpha	Homo sapiens	42-46
2124488-3	1990	At 10-30 micrograms/ml, genistein blocked IL-1 stimulated prostaglandin production and induction of prostaglandin endoperoxide synthase (PES) in glomerular mesangial cells maintained in 10% serum.	Prostaglandins	58-71	interleukin 1 alpha	Homo sapiens	42-46
2124488-6	1990	Overall these data suggest that tyrosine phosphorylation may be a required event for IL-1 stimulation of PGE2 and PES activity, either directly as part of IL-1 signaling, or indirectly as part of a serum/PDGF competence effect on mesangial cells.	Tyrosine	32-40	interleukin 1 alpha	Homo sapiens	85-89
2124488-6	1990	Overall these data suggest that tyrosine phosphorylation may be a required event for IL-1 stimulation of PGE2 and PES activity, either directly as part of IL-1 signaling, or indirectly as part of a serum/PDGF competence effect on mesangial cells.	Tyrosine	32-40	interleukin 1 alpha	Homo sapiens	155-159
2124488-6	1990	Overall these data suggest that tyrosine phosphorylation may be a required event for IL-1 stimulation of PGE2 and PES activity, either directly as part of IL-1 signaling, or indirectly as part of a serum/PDGF competence effect on mesangial cells.	Dinoprostone	105-109	interleukin 1 alpha	Homo sapiens	85-89
2124488-6	1990	Overall these data suggest that tyrosine phosphorylation may be a required event for IL-1 stimulation of PGE2 and PES activity, either directly as part of IL-1 signaling, or indirectly as part of a serum/PDGF competence effect on mesangial cells.	Dinoprostone	105-109	interleukin 1 alpha	Homo sapiens	155-159
2175325-0	1990	cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.	Cyclic AMP	0-4	interleukin 1 alpha	Homo sapiens	14-18
2175325-5	1990	Concomitantly we were able to show that IL-1 increased the cytosolic cAMP levels in endothelial cells.	Cyclic AMP	69-73	interleukin 1 alpha	Homo sapiens	40-44
2175325-6	1990	An inhibitor of adenylate cyclase, ddAdo, decreased both the IL-1-induced cAMP elevation and lymphocyte penetration.	Dideoxyadenosine	35-40	interleukin 1 alpha	Homo sapiens	61-65
2175325-6	1990	An inhibitor of adenylate cyclase, ddAdo, decreased both the IL-1-induced cAMP elevation and lymphocyte penetration.	Cyclic AMP	74-78	interleukin 1 alpha	Homo sapiens	61-65
2175325-7	1990	A protein kinase A inhibitor HA 1004 could inhibit the IL-1-induced lymphocyte penetration, where as protein kinase C (N-(2-guamidino-ethyl)-5-isoquinolinesyl foamide hydrocloride) and calcium-calmodulin (N-(6-aminohexyl)-5-chloro-1-naphthalensulfanamide) inhibitors had no effect.	N-(2-guanidinoethyl)-5-isoquinolinesulfonamide	29-36	interleukin 1 alpha	Homo sapiens	55-59
2175325-7	1990	A protein kinase A inhibitor HA 1004 could inhibit the IL-1-induced lymphocyte penetration, where as protein kinase C (N-(2-guamidino-ethyl)-5-isoquinolinesyl foamide hydrocloride) and calcium-calmodulin (N-(6-aminohexyl)-5-chloro-1-naphthalensulfanamide) inhibitors had no effect.	n-(2-guamidino-ethyl)-5-isoquinolinesyl foamide hydrocloride	119-179	interleukin 1 alpha	Homo sapiens	55-59
2175325-7	1990	A protein kinase A inhibitor HA 1004 could inhibit the IL-1-induced lymphocyte penetration, where as protein kinase C (N-(2-guamidino-ethyl)-5-isoquinolinesyl foamide hydrocloride) and calcium-calmodulin (N-(6-aminohexyl)-5-chloro-1-naphthalensulfanamide) inhibitors had no effect.	n-(6-aminohexyl)-5-chloro-1-naphthalensulfanamide	205-254	interleukin 1 alpha	Homo sapiens	55-59
2175325-9	1990	These data support the view that IL-1 acts via cAMP as a second messenger in regard to lymphocyte penetration through endothelial cells.	Cyclic AMP	47-51	interleukin 1 alpha	Homo sapiens	33-37
2175325-10	1990	The above data demonstrate that IL-1-induced lymphocyte penetration through endothelial cells and that this IL-1-induced signal is transduced via cAMP in endothelial cells.	Cyclic AMP	146-150	interleukin 1 alpha	Homo sapiens	32-36
2175325-10	1990	The above data demonstrate that IL-1-induced lymphocyte penetration through endothelial cells and that this IL-1-induced signal is transduced via cAMP in endothelial cells.	Cyclic AMP	146-150	interleukin 1 alpha	Homo sapiens	108-112
2175610-1	1990	Interleukin-1 (IL-1) has been shown to regulate glycosaminoglycan (GAG) synthesis.	Glycosaminoglycans	48-65	interleukin 1 alpha	Homo sapiens	0-13
1963325-2	1990	IL-1 inhibited FSH induction of aromatase activity and of LH-stimulated cAMP accumulation by granulosa cells.	Cyclic AMP	72-76	interleukin 1 alpha	Homo sapiens	0-4
1963325-5	1990	IL-1 also significantly inhibited increases in [125I]iodo-LH binding and progesterone secretion induced by FSH, as well as reducing basal levels of aromatase activity and LH-stimulated cAMP accumulation.	iodo-lh	53-60	interleukin 1 alpha	Homo sapiens	0-4
1963325-5	1990	IL-1 also significantly inhibited increases in [125I]iodo-LH binding and progesterone secretion induced by FSH, as well as reducing basal levels of aromatase activity and LH-stimulated cAMP accumulation.	Cyclic AMP	185-189	interleukin 1 alpha	Homo sapiens	0-4
1963325-6	1990	Studies on the mechanisms of IL-1 actions on FSH-induced differentiation of immature porcine granulosa cells revealed that IL-1 reduced cAMP accumulation by the cells in response to FSH in a time- and concentration-dependent manner.	Cyclic AMP	136-140	interleukin 1 alpha	Homo sapiens	29-33
1963325-6	1990	Studies on the mechanisms of IL-1 actions on FSH-induced differentiation of immature porcine granulosa cells revealed that IL-1 reduced cAMP accumulation by the cells in response to FSH in a time- and concentration-dependent manner.	Cyclic AMP	136-140	interleukin 1 alpha	Homo sapiens	123-127
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Colchicine	48-58	interleukin 1 alpha	Homo sapiens	176-179
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Colchicine	48-58	interleukin 1 alpha	Homo sapiens	229-232
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Vinblastine	60-71	interleukin 1 alpha	Homo sapiens	176-179
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Vinblastine	60-71	interleukin 1 alpha	Homo sapiens	229-232
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Vincristine	77-88	interleukin 1 alpha	Homo sapiens	176-179
2242502-3	1990	On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells.	Vincristine	77-88	interleukin 1 alpha	Homo sapiens	229-232
2147409-9	1990	Quinolinic acid lesion studies demonstrated that the [125I]IL-1 alpha-binding sites in the hippocampus were localized to intrinsic neurons.	Quinolinic Acid	0-15	interleukin 1 alpha	Homo sapiens	59-69
2174073-0	1990	IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway.	Prostaglandins	162-175	interleukin 1 alpha	Homo sapiens	0-4
2174073-0	1990	IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway.	Cyclic AMP	206-210	interleukin 1 alpha	Homo sapiens	0-4
2174073-2	1990	cAMP has been shown to inhibit stromelysin transcription in fibroblasts of nonsynovial origin, and is regarded as an important second messenger for IL-1.	Cyclic AMP	0-4	interleukin 1 alpha	Homo sapiens	148-152
2174073-3	1990	In addition to stimulating metalloproteinase transcription, IL-1 also induces PGE2 production in synoviocytes.	Dinoprostone	78-82	interleukin 1 alpha	Homo sapiens	60-64
2125363-6	1990	Both IL-1 alpha and IL-1 beta induced production of IL-6 mRNA and of PGE2 in these cell types.	Dinoprostone	69-73	interleukin 1 alpha	Homo sapiens	5-15
1700731-7	1990	The transcription inhibitor, actinomycin D, and protein synthesis inhibitor, cycloheximide, inhibited the increase in GM-CSF and G-CSF production induced by IL-1 and TNF.	Dactinomycin	29-42	interleukin 1 alpha	Homo sapiens	157-161
1700731-7	1990	The transcription inhibitor, actinomycin D, and protein synthesis inhibitor, cycloheximide, inhibited the increase in GM-CSF and G-CSF production induced by IL-1 and TNF.	Cycloheximide	77-90	interleukin 1 alpha	Homo sapiens	157-161
2228314-4	1990	3H-thymidine incorporation by the LIM1215 cell line was stimulated by low concentrations of epidermal growth factor and basic fibroblast growth factor and, to a lesser extent, by higher concentrations of interleukin-1 and insulin-like growth factor 1.	Tritium	0-2	interleukin 1 alpha	Homo sapiens	204-250
2228314-4	1990	3H-thymidine incorporation by the LIM1215 cell line was stimulated by low concentrations of epidermal growth factor and basic fibroblast growth factor and, to a lesser extent, by higher concentrations of interleukin-1 and insulin-like growth factor 1.	Thymidine	3-12	interleukin 1 alpha	Homo sapiens	204-250
2244911-8	1990	Prolonged exposure of HUVEC to phorbol myristate acetate down-regulated PKC activity and inhibited subsequent ICAM-1 up-regulation by this agent and by IL-1.	Tetradecanoylphorbol Acetate	31-56	interleukin 1 alpha	Homo sapiens	152-156
2124239-3	1990	To examine the role of protein kinase C (PKC) in IL-1-mediated PGE2 production, we treated cells with PMA, which stimulated PGE2 production suggesting a positive role for PKC activation in the regulation of PGE2 synthesis.	Dinoprostone	124-128	interleukin 1 alpha	Homo sapiens	49-53
2124239-4	1990	Therefore, we tested the effect of sphingosine, a PKC inhibitor, on IL-1-induced PGE2 production.	Sphingosine	35-46	interleukin 1 alpha	Homo sapiens	68-72
2125233-4	1990	Cells from patients with adrenomyeloneuropathy, however, had significantly lower cytokine-stimulated cyclooxygenase and phospholipase A2 activities than normals, as well as lower prostaglandin E2 synthesis in response to interleukin 1.	Dinoprostone	179-195	interleukin 1 alpha	Homo sapiens	221-234
2125233-0	1990	Arachidonic acid metabolism in fibroblasts from patients with peroxisomal diseases: response to interleukin 1.	Arachidonic Acid	0-16	interleukin 1 alpha	Homo sapiens	96-109
2125233-2	1990	Basal- as well as interleukin 1-stimulated prostaglandin E2 syntheses were higher in fibroblasts from patients with X-linked adrenoleukodystrophy, the Zellweger cerebrohepatorenal syndrome and rhizomelic chondrodysplasia punctata than in normals.	Dinoprostone	43-59	interleukin 1 alpha	Homo sapiens	18-31
2125233-7	1990	Exaggerated arachidonic acid metabolism in response to interleukin 1 suggests that cells from patients with peroxisomal enzyme defects may be useful in elucidating pathways for arachidonate release and eicosanoid synthesis.	Arachidonic Acid	12-28	interleukin 1 alpha	Homo sapiens	55-68
2150741-4	1990	When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis.	Etodolac	53-61	interleukin 1 alpha	Homo sapiens	31-44
2150741-4	1990	When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis.	Etodolac	53-61	interleukin 1 alpha	Homo sapiens	46-50
2150741-4	1990	When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis.	Glycosaminoglycans	101-104	interleukin 1 alpha	Homo sapiens	31-44
2150741-4	1990	When cells were incubated with Interleukin-1 (IL-1), Etodolac still exerted its inhibiting effect on GAG synthesis.	Glycosaminoglycans	101-104	interleukin 1 alpha	Homo sapiens	46-50
2240247-7	1990	However, when sampled 20 min after 10.8 micrograms IL-1 alpha (20-min study, n = 6), CSF levels of all prostanoids except for TxB2 significantly increased over the controls.	Prostaglandins	103-114	interleukin 1 alpha	Homo sapiens	51-61
2240281-4	1990	Plasma obtained 3 h after endotoxin injection inhibited IL-1-induced PGE2 release from fibroblasts by 57% (P less than 0.001 vs. baseline and saline controls, respectively).	Dinoprostone	69-73	interleukin 1 alpha	Homo sapiens	56-60
2127553-0	1990	Interleukin-1 potentiates histamine-induced release of prostacyclin from human endothelial cells.	Histamine	26-35	interleukin 1 alpha	Homo sapiens	0-13
2127553-0	1990	Interleukin-1 potentiates histamine-induced release of prostacyclin from human endothelial cells.	Epoprostenol	55-67	interleukin 1 alpha	Homo sapiens	0-13
2127553-2	1990	In human cultured umbilical vein endothelial cells, interleukin-1 potentiated histamine-induced release of prostacyclin in a time- and concentration-dependent manner.	Histamine	78-87	interleukin 1 alpha	Homo sapiens	52-65
2127553-2	1990	In human cultured umbilical vein endothelial cells, interleukin-1 potentiated histamine-induced release of prostacyclin in a time- and concentration-dependent manner.	Epoprostenol	107-119	interleukin 1 alpha	Homo sapiens	52-65
2127553-4	1990	In cells incubated with interleukin-1 for 24 h, maximal potentiation was observed when cells were pre-incubated with 0.5 u ml-1 interleukin-1 before stimulation with histamine (1 microM-1 mM).	Histamine	166-175	interleukin 1 alpha	Homo sapiens	24-37
2127553-4	1990	In cells incubated with interleukin-1 for 24 h, maximal potentiation was observed when cells were pre-incubated with 0.5 u ml-1 interleukin-1 before stimulation with histamine (1 microM-1 mM).	Histamine	166-175	interleukin 1 alpha	Homo sapiens	128-141
2127553-6	1990	In cells incubated with 0.5 u ml-1 interleukin-1, 20 min pre-incubation was sufficient to induce a statistically significant potentiation of prostacyclin release induced by 1 microM histamine (P less than 0.05).	Epoprostenol	141-153	interleukin 1 alpha	Homo sapiens	35-48
2127553-6	1990	In cells incubated with 0.5 u ml-1 interleukin-1, 20 min pre-incubation was sufficient to induce a statistically significant potentiation of prostacyclin release induced by 1 microM histamine (P less than 0.05).	Histamine	182-191	interleukin 1 alpha	Homo sapiens	35-48
2290027-3	1990	In addition to short acting stimuli like thrombin and histamine an increased prostanoid release occurs in the presence of endotoxin, interleukin 1 or tumor necrosis factor (TNF).	Histamine	54-63	interleukin 1 alpha	Homo sapiens	133-171
2290027-3	1990	In addition to short acting stimuli like thrombin and histamine an increased prostanoid release occurs in the presence of endotoxin, interleukin 1 or tumor necrosis factor (TNF).	Prostaglandins	77-87	interleukin 1 alpha	Homo sapiens	133-171
1700730-2	1990	We demonstrate that both IL-1 alpha and IL-1 beta treatment of these cells led to stimulation of DNA synthesis (as shown by increase of 3H-thymidine incorporation up to 35-fold) and also resulted in colony formation of leukemic megakaryoblasts.	3h-thymidine	136-148	interleukin 1 alpha	Homo sapiens	25-35
2150741-6	1990	IL-1 alone or in combination with Etodolac decreased the synthesis of GAGs suggesting that pretreatment with Etodolac cannot prevent the action of IL-1.	Glycosaminoglycans	70-74	interleukin 1 alpha	Homo sapiens	0-4
2150741-8	1990	In presence of IL-1, Etodolac at the highest concentration partially diminished the stimulatory effect of IL-1.	Etodolac	21-29	interleukin 1 alpha	Homo sapiens	15-19
2150741-8	1990	In presence of IL-1, Etodolac at the highest concentration partially diminished the stimulatory effect of IL-1.	Etodolac	21-29	interleukin 1 alpha	Homo sapiens	106-110
2150741-10	1990	In the same experiment, IL-1 alone caused a slight increase of GAG production that was not abolished by Etodolac treatment.	Glycosaminoglycans	63-66	interleukin 1 alpha	Homo sapiens	24-28
2240247-0	1990	Recombinant human interleukin 1 alpha dilates pial arterioles and increases cerebrospinal fluid prostanoids in piglets.	Prostaglandins	96-107	interleukin 1 alpha	Homo sapiens	18-37
2127553-8	1990	Nifedipine but not cycloheximide, significantly (P less than 0.05) inhibited histamine-induced release of prostacyclin and interleukin-1 potentiation of histamine-induced release of prostacyclin (P less than 0.05).	Nifedipine	0-10	interleukin 1 alpha	Homo sapiens	123-136
2127553-8	1990	Nifedipine but not cycloheximide, significantly (P less than 0.05) inhibited histamine-induced release of prostacyclin and interleukin-1 potentiation of histamine-induced release of prostacyclin (P less than 0.05).	Histamine	77-86	interleukin 1 alpha	Homo sapiens	123-136
2127553-8	1990	Nifedipine but not cycloheximide, significantly (P less than 0.05) inhibited histamine-induced release of prostacyclin and interleukin-1 potentiation of histamine-induced release of prostacyclin (P less than 0.05).	Histamine	153-162	interleukin 1 alpha	Homo sapiens	123-136
2127553-8	1990	Nifedipine but not cycloheximide, significantly (P less than 0.05) inhibited histamine-induced release of prostacyclin and interleukin-1 potentiation of histamine-induced release of prostacyclin (P less than 0.05).	Epoprostenol	182-194	interleukin 1 alpha	Homo sapiens	123-136
2127553-14	1990	These results suggest that interleukin-1 potentiates histamine-induced release of prostacyclin by rapid up-regulation of prostaglandin synthetase activity as well as by inducing synthesis of enzyme protein.	Histamine	53-62	interleukin 1 alpha	Homo sapiens	27-40
2127553-14	1990	These results suggest that interleukin-1 potentiates histamine-induced release of prostacyclin by rapid up-regulation of prostaglandin synthetase activity as well as by inducing synthesis of enzyme protein.	Epoprostenol	82-94	interleukin 1 alpha	Homo sapiens	27-40
2104237-7	1990	IL 1 concentration was high in spontaneous (IL 1 alpha, 3.7; IL 1 beta, 0.3 ng/mL) and pilocarpine induced sweat (IL 1 alpha, 3.9; IL 1 beta, 1.2 ng/mL), and it was much increased during jogging and sauna (IL 1 alpha, 22.6; IL 1 beta, 3.3 ng/mL).	Pilocarpine	87-98	interleukin 1 alpha	Homo sapiens	0-4
2104237-7	1990	IL 1 concentration was high in spontaneous (IL 1 alpha, 3.7; IL 1 beta, 0.3 ng/mL) and pilocarpine induced sweat (IL 1 alpha, 3.9; IL 1 beta, 1.2 ng/mL), and it was much increased during jogging and sauna (IL 1 alpha, 22.6; IL 1 beta, 3.3 ng/mL).	Pilocarpine	87-98	interleukin 1 alpha	Homo sapiens	114-124
2104237-7	1990	IL 1 concentration was high in spontaneous (IL 1 alpha, 3.7; IL 1 beta, 0.3 ng/mL) and pilocarpine induced sweat (IL 1 alpha, 3.9; IL 1 beta, 1.2 ng/mL), and it was much increased during jogging and sauna (IL 1 alpha, 22.6; IL 1 beta, 3.3 ng/mL).	Pilocarpine	87-98	interleukin 1 alpha	Homo sapiens	114-124
2074250-8	1990	In-vitro data on cefodizime, a third generation cephalosporin that achieves good tissue levels, are presented and show the ability of the intact antibiotic, as well as its immunomodulating side-chain, to down-regulate TNF and interleukin 1 (IL-1) released from human monocytes by lectin-activated lymphocytes, LPS and IFN.	cefodizime	17-27	interleukin 1 alpha	Homo sapiens	226-245
2074251-4	1990	Data obtained both in vivo and ex vivo show that cefodizime enhances various immune parameters such as phagocyte function, B lymphocyte responsiveness and delayed hypersensitivity; it may restore natural killer (NK) and phagocyte activity, as well as interleukin 1 (IL-1) and interferon production, in immunocompromised patients and animals.	cefodizime	49-59	interleukin 1 alpha	Homo sapiens	251-270
2208307-6	1990	GM-CSF treatment enabled M phi to produce more interleukin (IL)-1 and IL-6 upon stimulation with lipopolysaccharides or polyinosinic-polycytidylic acid, but was unable to stimulate M phi directly.	Poly I-C	120-151	interleukin 1 alpha	Homo sapiens	47-65
2125233-7	1990	Exaggerated arachidonic acid metabolism in response to interleukin 1 suggests that cells from patients with peroxisomal enzyme defects may be useful in elucidating pathways for arachidonate release and eicosanoid synthesis.	Arachidonic Acid	177-189	interleukin 1 alpha	Homo sapiens	55-68
2125233-7	1990	Exaggerated arachidonic acid metabolism in response to interleukin 1 suggests that cells from patients with peroxisomal enzyme defects may be useful in elucidating pathways for arachidonate release and eicosanoid synthesis.	Eicosanoids	202-212	interleukin 1 alpha	Homo sapiens	55-68
2144978-4	1990	The inhibitor blocks IL-1-induced prostaglandin E2 production by human fibroblasts and the IL-1-related increase of phytohemagglutinin-induced murine thymocyte proliferation.	Dinoprostone	34-50	interleukin 1 alpha	Homo sapiens	21-25
2278877-3	1990	This cell line specifically requires bFGF, interleukin 1, or transforming growth factor e for anchorage-independent growth in soft agar.	Agar	131-135	interleukin 1 alpha	Homo sapiens	43-89
2257173-0	1990	Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.	Lipid A	22-29	interleukin 1 alpha	Homo sapiens	101-114
2257173-0	1990	Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.	Lipid A	74-81	interleukin 1 alpha	Homo sapiens	101-114
2257173-1	1990	Experiments were designed to investigate the significance of lipid A partial structures, precursor Ia (compound 406), and lipid X (compound 401) to serve as antagonists of interleukin 1 (IL-1) release from human mononuclear cells and monocytes induced by lipopolysaccharide (LPS, endotoxin) of Salmonella abortus equi or synthetic Escherichia coli lipid A (compound 506).	Lipid A	61-68	interleukin 1 alpha	Homo sapiens	172-185
2257173-1	1990	Experiments were designed to investigate the significance of lipid A partial structures, precursor Ia (compound 406), and lipid X (compound 401) to serve as antagonists of interleukin 1 (IL-1) release from human mononuclear cells and monocytes induced by lipopolysaccharide (LPS, endotoxin) of Salmonella abortus equi or synthetic Escherichia coli lipid A (compound 506).	Lipid A	61-68	interleukin 1 alpha	Homo sapiens	187-191
2257173-1	1990	Experiments were designed to investigate the significance of lipid A partial structures, precursor Ia (compound 406), and lipid X (compound 401) to serve as antagonists of interleukin 1 (IL-1) release from human mononuclear cells and monocytes induced by lipopolysaccharide (LPS, endotoxin) of Salmonella abortus equi or synthetic Escherichia coli lipid A (compound 506).	lipid X	122-129	interleukin 1 alpha	Homo sapiens	172-185
2257173-1	1990	Experiments were designed to investigate the significance of lipid A partial structures, precursor Ia (compound 406), and lipid X (compound 401) to serve as antagonists of interleukin 1 (IL-1) release from human mononuclear cells and monocytes induced by lipopolysaccharide (LPS, endotoxin) of Salmonella abortus equi or synthetic Escherichia coli lipid A (compound 506).	lipid X	122-129	interleukin 1 alpha	Homo sapiens	187-191
2257173-2	1990	A definite inhibition mediated by lipid A partial structures on IL-1 release induced by LPS or lipid A was found in repeated experiments.	Lipid A	34-41	interleukin 1 alpha	Homo sapiens	64-68
2257173-2	1990	A definite inhibition mediated by lipid A partial structures on IL-1 release induced by LPS or lipid A was found in repeated experiments.	Lipid A	95-102	interleukin 1 alpha	Homo sapiens	64-68
2257173-5	1990	We conclude from these results that lipid A partial structures (precursor Ia and lipid X) have potent immunomodulatory effects on LPS- and lipid A-induced IL-1 release and may become useful reagents to study the mechanism of interaction of LPS and lipid A with cells of the immune system.	Lipid A	36-43	interleukin 1 alpha	Homo sapiens	155-159
2257173-5	1990	We conclude from these results that lipid A partial structures (precursor Ia and lipid X) have potent immunomodulatory effects on LPS- and lipid A-induced IL-1 release and may become useful reagents to study the mechanism of interaction of LPS and lipid A with cells of the immune system.	Lipid A	139-146	interleukin 1 alpha	Homo sapiens	155-159
2257173-5	1990	We conclude from these results that lipid A partial structures (precursor Ia and lipid X) have potent immunomodulatory effects on LPS- and lipid A-induced IL-1 release and may become useful reagents to study the mechanism of interaction of LPS and lipid A with cells of the immune system.	Lipid A	139-146	interleukin 1 alpha	Homo sapiens	155-159
2398274-7	1990	We further demonstrated that the inhibitory IgG which was bound to protein A Sepharose could bind a significant amount of 125I-IL-1 alpha, whereas only a negligible binding of the radiolabeled ligand was detected when IgG without the inhibitory activity was used as control.	Sepharose	77-86	interleukin 1 alpha	Homo sapiens	127-137
2254900-2	1990	Pretreatment of chondrocytes with actinomycin D or cycloheximide significantly inhibited IL-1 induced PLA2 activation and secretion, suggesting that the enzyme induction process is RNA and protein synthesis dependent.	Dactinomycin	34-47	interleukin 1 alpha	Homo sapiens	89-93
2254900-2	1990	Pretreatment of chondrocytes with actinomycin D or cycloheximide significantly inhibited IL-1 induced PLA2 activation and secretion, suggesting that the enzyme induction process is RNA and protein synthesis dependent.	Cycloheximide	51-64	interleukin 1 alpha	Homo sapiens	89-93
1702455-0	1990	Increased superoxide anion release from chondrocytes in response to interleukin 1 and interferons.	Superoxides	10-26	interleukin 1 alpha	Homo sapiens	68-81
1702455-1	1990	In order to investigate a possible mechanism of degradation of cartilage matrix in chronic inflammation, superoxide anion (O2-) release from chondrocytes after stimulation with interleukin 1 (IL 1) and interferons (IFNs) has been studied.	Superoxides	105-121	interleukin 1 alpha	Homo sapiens	177-196
1702455-1	1990	In order to investigate a possible mechanism of degradation of cartilage matrix in chronic inflammation, superoxide anion (O2-) release from chondrocytes after stimulation with interleukin 1 (IL 1) and interferons (IFNs) has been studied.	Superoxides	123-125	interleukin 1 alpha	Homo sapiens	177-196
2174138-3	1990	On the basis of other studies that showed interleukin 1 can stimulate fibroblasts and macrophages to produce collagenases and prostaglandins, we then proposed that interleukin 1 may play an important role in cholesteatoma-related bone resorption, also.	Prostaglandins	126-140	interleukin 1 alpha	Homo sapiens	42-55
2174138-3	1990	On the basis of other studies that showed interleukin 1 can stimulate fibroblasts and macrophages to produce collagenases and prostaglandins, we then proposed that interleukin 1 may play an important role in cholesteatoma-related bone resorption, also.	Prostaglandins	126-140	interleukin 1 alpha	Homo sapiens	164-177
2174138-6	1990	By radioimmunoassay, interleukin 1 was shown to stimulate the production of prostaglandin E2 by osteoblasts in vitro.	Dinoprostone	76-92	interleukin 1 alpha	Homo sapiens	21-34
2128549-7	1990	Indirect Id stimulation of group-1 cells by Id-I or Id-C, and group-2 cells by Id-I or EPI, was inhibited by anti-HLA-DR,DP(DQ) mAb or sodium azide, and exogenous IL-1 alone did not support this processed, MHC-mediated T-cell stimulation, but live adherent cells did.	dp	121-123	interleukin 1 alpha	Homo sapiens	163-167
2128549-7	1990	Indirect Id stimulation of group-1 cells by Id-I or Id-C, and group-2 cells by Id-I or EPI, was inhibited by anti-HLA-DR,DP(DQ) mAb or sodium azide, and exogenous IL-1 alone did not support this processed, MHC-mediated T-cell stimulation, but live adherent cells did.	Sodium Azide	135-147	interleukin 1 alpha	Homo sapiens	163-167
2218499-4	1990	Treatment of human endothelial cell populations with an antisense oligodeoxynucleotide to the human IL-1 alpha transcript prevented cell senescence and extended the proliferative life-span of the cells in vitro.	Oligodeoxyribonucleotides	66-86	interleukin 1 alpha	Homo sapiens	100-110
2125034-1	1990	We have studied the in vitro effects of gold sodium thiomalate (GST) and auranofin (Auf) on the production of interleukin 1 (IL1) expressed as thymocyte co-stimulatory activity (TCSA), and interleukin 1 beta (IL1 beta) as modulated by interferon gamma (IFN gamma).	Gold Sodium Thiomalate	40-62	interleukin 1 alpha	Homo sapiens	110-128
2125034-1	1990	We have studied the in vitro effects of gold sodium thiomalate (GST) and auranofin (Auf) on the production of interleukin 1 (IL1) expressed as thymocyte co-stimulatory activity (TCSA), and interleukin 1 beta (IL1 beta) as modulated by interferon gamma (IFN gamma).	Auranofin	73-82	interleukin 1 alpha	Homo sapiens	110-128
2203800-2	1990	[35S]Methionine incorporation into IL-1 induced, immunoprecipitable HLA-DR molecules demonstrated de novo synthesis of both light and heavy chains of the HLA-DR molecules.	Sulfur-35	1-4	interleukin 1 alpha	Homo sapiens	35-39
2203800-2	1990	[35S]Methionine incorporation into IL-1 induced, immunoprecipitable HLA-DR molecules demonstrated de novo synthesis of both light and heavy chains of the HLA-DR molecules.	Methionine	5-15	interleukin 1 alpha	Homo sapiens	35-39
2203800-5	1990	Pretreatment of T47D cells with estradiol-17 beta significantly decreased the IL-1 induced HLA-DR expression, and pretreatment of IL-1 with an IL-1 specific antibody, neutralized IL-1 action.	Estradiol	32-49	interleukin 1 alpha	Homo sapiens	78-82
1981242-4	1990	Dexamethasone (10-100 nM) inhibited IL-1 production and IL-1 mediated thymocyte proliferation.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	36-40
1981242-4	1990	Dexamethasone (10-100 nM) inhibited IL-1 production and IL-1 mediated thymocyte proliferation.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	56-60
1981242-5	1990	High concentrations of indomethacin, aspirin, and 12 other nonsteroidal antiinflammatory drugs (NSAID) inhibited IL-1 activity, or production or both.	Indomethacin	23-35	interleukin 1 alpha	Homo sapiens	113-117
1981242-5	1990	High concentrations of indomethacin, aspirin, and 12 other nonsteroidal antiinflammatory drugs (NSAID) inhibited IL-1 activity, or production or both.	Aspirin	37-44	interleukin 1 alpha	Homo sapiens	113-117
1981242-6	1990	Methotrexate inhibited IL-1 activity without affecting IL-1 production.	Methotrexate	0-12	interleukin 1 alpha	Homo sapiens	23-27
1981242-7	1990	D-penicillamine inhibited IL-1 activity and tended to inhibit IL-1 production.	Penicillamine	0-15	interleukin 1 alpha	Homo sapiens	26-30
1981242-7	1990	D-penicillamine inhibited IL-1 activity and tended to inhibit IL-1 production.	Penicillamine	0-15	interleukin 1 alpha	Homo sapiens	62-66
1981242-8	1990	Gold compounds inhibited IL-1 activity, but only auranofin inhibited IL-1 production.	Auranofin	49-58	interleukin 1 alpha	Homo sapiens	69-73
1981242-9	1990	Acetaminophen in high concentrations (1 mg/ml) inhibited IL-1 activity and production.	Acetaminophen	0-13	interleukin 1 alpha	Homo sapiens	57-61
1981242-10	1990	Colchicine inhibited IL-1 activity but not IL-1 production.	Colchicine	0-10	interleukin 1 alpha	Homo sapiens	21-25
2230430-3	1990	As a result, IL-1 suppressed dose-dependently the secretion of both 35S and 3H into the supernatant of the medium containing free human or porcine chondrocytes.	Sulfur-35	68-71	interleukin 1 alpha	Homo sapiens	13-17
2230430-3	1990	As a result, IL-1 suppressed dose-dependently the secretion of both 35S and 3H into the supernatant of the medium containing free human or porcine chondrocytes.	Tritium	76-78	interleukin 1 alpha	Homo sapiens	13-17
2212685-0	1990	Bioassay of interleukin-1 in serum and plasma following removal of inhibitory activity with polyethylene glycol.	Polyethylene Glycols	92-111	interleukin 1 alpha	Homo sapiens	12-25
2212685-3	1990	The IL-1 bioassay could be performed in the presence of a 3% concentration of PEG and recovery of added natural IL-1 from plasma or serum was essentially complete.	Polyethylene Glycols	78-81	interleukin 1 alpha	Homo sapiens	4-8
1699434-6	1990	Appreciable amounts of immunoreactive IL-1 and IL-6 were indeed recovered in the supernatants of TDI-exposed epithelial cells.	Toluene 2,4-Diisocyanate	97-100	interleukin 1 alpha	Homo sapiens	38-42
2121110-7	1990	We found that no single cytokine, but rather a specific combination of tumor necrosis factor, interleukin-1, interferon-gamma, and endotoxin, were required for maximal induction of HC nitrogen oxide production.	Nitrogen Oxides	184-198	interleukin 1 alpha	Homo sapiens	94-107
2146113-7	1990	Alveolar macrophages from bituminous coal mine dust- or titanium dioxide-exposed lungs showed increased ability to release interleukin-1 on stimulation in vitro.	titanium dioxide	56-72	interleukin 1 alpha	Homo sapiens	123-136
2172158-0	1990	IL-1-induced production of IL-2 and IFN-gamma in subclones of human T-cell derived leukaemia HSB.2 cells: regulation by phytohaemagglutinin-mediated (poly)phosphoinositide breakdown and cyclic AMP.	Cyclic AMP	186-196	interleukin 1 alpha	Homo sapiens	0-4
2172158-11	1990	These results indicate that the variation of IL-1-induced production of IL-2 and IFN-gamma in this T-cell line is attributed to the difference in the PHA-mediated signal transduction pathway and, presumably, to the different regulation of intracellular cyclic AMP.	Cyclic AMP	253-263	interleukin 1 alpha	Homo sapiens	45-49
2258168-2	1990	In the fetal thymus immunoreactivity for IL-1 alpha was mainly confined to the medulla and was detected in S-100 positive interdigitating reticulum cells.	s-100	107-112	interleukin 1 alpha	Homo sapiens	41-51
2144546-0	1990	Obligatory action of polypeptide growth factors for the IL-1-mediated prostaglandin E2 production in fibroblasts.	Dinoprostone	70-86	interleukin 1 alpha	Homo sapiens	56-60
2144546-2	1990	Our studies show that in connective tissue cells, induction of PGE2 synthesis in response to IL-1 requires costimulation with platelet-derived growth factor (PDGF) or fibroblast growth factor (FGF).	Dinoprostone	63-67	interleukin 1 alpha	Homo sapiens	93-97
2144546-3	1990	In cells incubated in medium containing fresh serum, IL-1 induced a dose-dependent synthesis of PGE2.	Dinoprostone	96-100	interleukin 1 alpha	Homo sapiens	53-57
2144546-6	1990	Addition of PDGF or FGF together with IL-1 resulted in a 14- and 66-fold stimulation of PGE2 synthesis, respectively.	Dinoprostone	88-92	interleukin 1 alpha	Homo sapiens	38-42
2144546-9	1990	In cells simultaneously treated with IL-1 and PDGF, PGE2 synthesis was initiated after a lag of 2 to 3 h, proceeded first with a rapid rate for 6 h, and then with a slower rate through 24 h. PGE2 synthesis during the latter, slower phase was greatly enhanced by pretreatment with PDGF, but not by pretreatment with IL-1.	Dinoprostone	52-56	interleukin 1 alpha	Homo sapiens	37-41
2144546-9	1990	In cells simultaneously treated with IL-1 and PDGF, PGE2 synthesis was initiated after a lag of 2 to 3 h, proceeded first with a rapid rate for 6 h, and then with a slower rate through 24 h. PGE2 synthesis during the latter, slower phase was greatly enhanced by pretreatment with PDGF, but not by pretreatment with IL-1.	Dinoprostone	52-56	interleukin 1 alpha	Homo sapiens	315-319
2144546-9	1990	In cells simultaneously treated with IL-1 and PDGF, PGE2 synthesis was initiated after a lag of 2 to 3 h, proceeded first with a rapid rate for 6 h, and then with a slower rate through 24 h. PGE2 synthesis during the latter, slower phase was greatly enhanced by pretreatment with PDGF, but not by pretreatment with IL-1.	Dinoprostone	191-195	interleukin 1 alpha	Homo sapiens	37-41
2144546-9	1990	In cells simultaneously treated with IL-1 and PDGF, PGE2 synthesis was initiated after a lag of 2 to 3 h, proceeded first with a rapid rate for 6 h, and then with a slower rate through 24 h. PGE2 synthesis during the latter, slower phase was greatly enhanced by pretreatment with PDGF, but not by pretreatment with IL-1.	Dinoprostone	191-195	interleukin 1 alpha	Homo sapiens	315-319
2169012-0	1990	A human IL-1 alpha derivative which lacks prostaglandin E2 inducing activity and inhibits the activity of IL-1 through receptor competition.	Dinoprostone	42-58	interleukin 1 alpha	Homo sapiens	8-18
2169012-4	1990	Although TN-55 bound to the receptor on MG-63 cells with a similar affinity as native IL-1 alpha, TN-55 not only failed in inducing PGE2 production but also antagonized the PGE2 inducing action of IL-1 alpha or IL-1 beta.	Dinoprostone	173-177	interleukin 1 alpha	Homo sapiens	197-207
2089426-8	1990	Furthermore, the combined addition of h-EC-contra-IL 1 and an antibody against rhIL 6 to cultures resulted in an additive inhibitory effect which could not be observed when hEC-contra-IL 1 was added together with a monoclonal antibody against rhIL 1 alpha/beta.	h-ec	38-42	interleukin 1 alpha	Homo sapiens	50-54
2089426-8	1990	Furthermore, the combined addition of h-EC-contra-IL 1 and an antibody against rhIL 6 to cultures resulted in an additive inhibitory effect which could not be observed when hEC-contra-IL 1 was added together with a monoclonal antibody against rhIL 1 alpha/beta.	h-ec	38-42	interleukin 1 alpha	Homo sapiens	184-188
2206968-0	1990	Effect of topical retinoic acid on the interleukin 1 alpha and beta immunoreactive pool in normal human epidermis.	Tretinoin	18-31	interleukin 1 alpha	Homo sapiens	39-58
1703554-1	1990	A histochemical study using a Biotin-Streptavidin procedure for demonstrating interleukin 1 (IL-1) in burn scar specimens is described.	Biotin	30-36	interleukin 1 alpha	Homo sapiens	78-97
2117032-4	1990	The expression of IL-1 activity by R-LPS-stimulated C3H/HeJ macrophages was unaffected by IFN-gamma; however, this cytokine significantly enhanced TNF-alpha production by the same cells.	r-lps	35-40	interleukin 1 alpha	Homo sapiens	18-22
2290154-6	1990	The 6-9 kDa inhibitor of IL-1 induced thymocyte proliferation alone also released calcium in a prostaglandin dependent manner with a mean RI of 2.29 at 200 inhibitory U/ml.	Calcium	82-89	interleukin 1 alpha	Homo sapiens	25-29
2290154-6	1990	The 6-9 kDa inhibitor of IL-1 induced thymocyte proliferation alone also released calcium in a prostaglandin dependent manner with a mean RI of 2.29 at 200 inhibitory U/ml.	Prostaglandins	95-108	interleukin 1 alpha	Homo sapiens	25-29
2285018-0	1990	Correlation of leukocyte interleukin-1 production with the stimulation of prostaglandin and tissue factor synthesis by human umbilical vein endothelial cells.	Prostaglandins	74-87	interleukin 1 alpha	Homo sapiens	25-38
2166110-4	1990	Agents previously shown to stimulate protein kinase C and to inhibit Ca2(+)-dependent, TCR-mediated thymocyte apoptosis, including IL-1, also blocked both DNA fragmentation and cell death in response to cAMP, suggesting interactions ("cross-talk") between the two protein kinase systems.	Cyclic AMP	203-207	interleukin 1 alpha	Homo sapiens	131-135
2166111-9	1990	Although IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta enhanced PGE2 stimulation of adenylate cyclase two- to four-fold in a dose-dependent manner.	Dinoprostone	86-90	interleukin 1 alpha	Homo sapiens	52-62
2380175-0	1990	Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters.	Hexoses	25-31	interleukin 1 alpha	Homo sapiens	0-13
2380175-1	1990	Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.	Lactic Acid	227-234	interleukin 1 alpha	Homo sapiens	121-149
2380175-1	1990	Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.	Lactic Acid	227-234	interleukin 1 alpha	Homo sapiens	151-170
2380175-11	1990	HuGi cells were pulse-labeled with [35S]methionine following exposure to IL1.	Methionine	40-50	interleukin 1 alpha	Homo sapiens	73-76
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Arginine	86-89	interleukin 1 alpha	Homo sapiens	25-36
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Lysine	91-94	interleukin 1 alpha	Homo sapiens	25-36
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Histidine	99-102	interleukin 1 alpha	Homo sapiens	25-36
2285018-8	1990	The results suggest that IL-1 released in monocyte neutrophil co-cultures can produce prothrombotic (increased PCA expression) and inflammatory changes (increased synthesis of vasodilatory and permeability enhancing PGI2 and PGE2) in endothelial cells.	Epoprostenol	216-220	interleukin 1 alpha	Homo sapiens	25-29
2285018-8	1990	The results suggest that IL-1 released in monocyte neutrophil co-cultures can produce prothrombotic (increased PCA expression) and inflammatory changes (increased synthesis of vasodilatory and permeability enhancing PGI2 and PGE2) in endothelial cells.	Dinoprostone	225-229	interleukin 1 alpha	Homo sapiens	25-29
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	fructose 2,6-diphosphate	184-209	interleukin 1 alpha	Homo sapiens	22-41
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	105-115
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	fructose 2,6-diphosphate	184-209	interleukin 1 alpha	Homo sapiens	43-53
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	151-161
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	151-161
2117917-7	1990	These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal.	Staurosporine	196-209	interleukin 1 alpha	Homo sapiens	28-38
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	fru(2,6)p2	211-221	interleukin 1 alpha	Homo sapiens	22-41
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	fru(2,6)p2	211-221	interleukin 1 alpha	Homo sapiens	43-53
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	Prostaglandins E	248-263	interleukin 1 alpha	Homo sapiens	22-41
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	Prostaglandins E	248-263	interleukin 1 alpha	Homo sapiens	43-53
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	Prostaglandins E	265-268	interleukin 1 alpha	Homo sapiens	22-41
2117917-2	1990	It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro.	Prostaglandins E	265-268	interleukin 1 alpha	Homo sapiens	43-53
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	Staurosporine	51-64	interleukin 1 alpha	Homo sapiens	78-88
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	fru(2,6)p2	110-120	interleukin 1 alpha	Homo sapiens	78-88
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	Prostaglandins E	126-129	interleukin 1 alpha	Homo sapiens	78-88
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	rsc	144-147	interleukin 1 alpha	Homo sapiens	78-88
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	Tetradecanoylphorbol Acetate	222-225	interleukin 1 alpha	Homo sapiens	78-88
2117917-4	1990	Staurosporine produced a similar enhancement of the response to IL-1 alpha by normal human dermal fibroblasts.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	64-74
2378930-0	1990	Interleukin-1 alpha increases thecal progesterone production of preovulatory follicles in cyclic hamsters.	Progesterone	37-49	interleukin 1 alpha	Homo sapiens	0-19
2378930-2	1990	IL-1 alpha increased progesterone secretion by preovulatory follicles during a 24-h incubation in RPMI-1640 medium containing hCG (100 mIU/ml) (progesterone levels: 17.5 +/- 2.2 vs. 10.6 +/- 1.9 ng/follicle/ml, p less than 0.05).	rpmi-1640 medium	98-114	interleukin 1 alpha	Homo sapiens	0-10
2224944-2	1990	Interleukin-1 increases the concentration of prostaglandin E2 and leukotriene B4, metabolites of arachidonic acid, which are potent mediators of inflammation.	Dinoprostone	45-61	interleukin 1 alpha	Homo sapiens	0-13
2171043-0	1990	Interleukin-1 stimulates diglyceride accumulation in the absence of protein kinase C activation.	Diglycerides	25-36	interleukin 1 alpha	Homo sapiens	0-13
2142016-0	1990	Calcium dependency of the production of interleukin 1 and the expression of interleukin 1 receptors of human adult T-cell leukemia cells in vitro.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	40-53
2142016-0	1990	Calcium dependency of the production of interleukin 1 and the expression of interleukin 1 receptors of human adult T-cell leukemia cells in vitro.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	76-89
2142016-1	1990	The effect of calcium on the production of interleukin 1 (IL 1) and the expression of IL 1 receptors (R) of adult T-cell leukemia (ATL) cells was studied in vitro.	Calcium	14-21	interleukin 1 alpha	Homo sapiens	43-62
2142016-1	1990	The effect of calcium on the production of interleukin 1 (IL 1) and the expression of IL 1 receptors (R) of adult T-cell leukemia (ATL) cells was studied in vitro.	Calcium	14-21	interleukin 1 alpha	Homo sapiens	58-62
2142016-2	1990	ATL cells freshly obtained from patients and ATL cell lines produced limited amounts of IL 1 by culturing in a low-calcium concentration of medium (less than 0.01 mM).	Calcium	115-122	interleukin 1 alpha	Homo sapiens	88-92
2142016-3	1990	However, the production of IL 1 was enhanced by the addition of calcium chloride to the medium in a concentration-dependent manner and reached the maximum at the higher calcium concentration (3-4 mM) than at the standard calcium concentration of medium (1.26 mM).	Calcium Chloride	64-80	interleukin 1 alpha	Homo sapiens	27-31
2142016-3	1990	However, the production of IL 1 was enhanced by the addition of calcium chloride to the medium in a concentration-dependent manner and reached the maximum at the higher calcium concentration (3-4 mM) than at the standard calcium concentration of medium (1.26 mM).	Calcium	64-71	interleukin 1 alpha	Homo sapiens	27-31
2142016-3	1990	However, the production of IL 1 was enhanced by the addition of calcium chloride to the medium in a concentration-dependent manner and reached the maximum at the higher calcium concentration (3-4 mM) than at the standard calcium concentration of medium (1.26 mM).	Calcium	169-176	interleukin 1 alpha	Homo sapiens	27-31
2142016-4	1990	The production of IL 1 from ATL cells was further enhanced by calcium ionophore.	Calcium	62-69	interleukin 1 alpha	Homo sapiens	18-22
2142016-8	1990	These results suggest that calcium plays a critical role in the regulation of the production of IL 1 and the expression of IL 1R on ATL cells.	Calcium	27-34	interleukin 1 alpha	Homo sapiens	96-100
2142181-8	1990	Partial purified H-161-derived IL-1 inhibitor showed specific binding to IL-1R-bearing cells and blocked the binding of IL-1 to its receptor and is thus similar to the urinary-derived molecule.	h-161	17-22	interleukin 1 alpha	Homo sapiens	31-35
1694171-1	1990	The monokine interleukin-1 (IL-1) inhibits endothelial cell growth and induces prostacyclin production in human endothelial cells.	Epoprostenol	79-91	interleukin 1 alpha	Homo sapiens	13-26
1694171-1	1990	The monokine interleukin-1 (IL-1) inhibits endothelial cell growth and induces prostacyclin production in human endothelial cells.	Epoprostenol	79-91	interleukin 1 alpha	Homo sapiens	28-32
1694171-2	1990	Since cyclooxygenase (Cox) is the rate-limiting enzyme in the synthesis of prostanoids, we evaluated the ability of IL-1 to stimulate Cox expression by human umbilical vein endothelial cells (HUVEC) in vitro.	Prostaglandins	75-86	interleukin 1 alpha	Homo sapiens	116-120
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Cycloheximide	234-247	interleukin 1 alpha	Homo sapiens	92-102
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Cycloheximide	234-247	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Cycloheximide	234-247	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Cycloheximide	234-247	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Dactinomycin	310-323	interleukin 1 alpha	Homo sapiens	92-102
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Dactinomycin	310-323	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Dactinomycin	310-323	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Dactinomycin	310-323	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Epoprostenol	463-475	interleukin 1 alpha	Homo sapiens	92-102
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Epoprostenol	463-475	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Epoprostenol	463-475	interleukin 1 alpha	Homo sapiens	191-201
1694171-3	1990	Our data demonstrate that 1) the Cox mRNA is expressed at low levels in untreated cells; 2) IL-1 alpha induces the Cox mRNA within 2 h, and this induction is sustained for more than 24 h; 3) IL-1 alpha induction is dose-dependent; 4) cycloheximide potentiates the induction of the Cox mRNA by IL-1 alpha while actinomycin D prevents the induction, and 5) IL-1 alpha also stimulates Cox production in a time-dependent fashion which correlates with the increase in prostacyclin synthesis.	Epoprostenol	463-475	interleukin 1 alpha	Homo sapiens	191-201
2390678-11	1990	A cyclo-oxygenase inhibitor, ketoprofen (3 mg kg-1) administered 15 min before either cytokine completely abolished the fever induced by both IL-1 alpha (2500 u kg-1) and IL-1 beta (500 u kg-1).	Ketoprofen	29-39	interleukin 1 alpha	Homo sapiens	142-152
2390678-13	1990	Intravenous administration of the steroidal anti-inflammatory agent dexamethasone (3 mg kg-1) 1 h before either cytokine attenuated the fever induced by IL-1 alpha (2500 u kg-1) and IL-1 beta (500 u kg-1).	Dexamethasone	68-81	interleukin 1 alpha	Homo sapiens	153-163
2129502-3	1990	LPS species that induced high levels of IL 1 release from human monocytes exhibited a high thiobarbiturate-reactive 2-keto-3-deoxy-octonic acid (KDO) content.	thiobarbituric acid	91-106	interleukin 1 alpha	Homo sapiens	40-44
2129502-3	1990	LPS species that induced high levels of IL 1 release from human monocytes exhibited a high thiobarbiturate-reactive 2-keto-3-deoxy-octonic acid (KDO) content.	2-keto-3-deoxy-octonic acid	116-143	interleukin 1 alpha	Homo sapiens	40-44
2129502-3	1990	LPS species that induced high levels of IL 1 release from human monocytes exhibited a high thiobarbiturate-reactive 2-keto-3-deoxy-octonic acid (KDO) content.	2-keto-3-deoxyoctonate	145-148	interleukin 1 alpha	Homo sapiens	40-44
2224944-2	1990	Interleukin-1 increases the concentration of prostaglandin E2 and leukotriene B4, metabolites of arachidonic acid, which are potent mediators of inflammation.	Leukotriene B4	66-80	interleukin 1 alpha	Homo sapiens	0-13
2224944-2	1990	Interleukin-1 increases the concentration of prostaglandin E2 and leukotriene B4, metabolites of arachidonic acid, which are potent mediators of inflammation.	Arachidonic Acid	97-113	interleukin 1 alpha	Homo sapiens	0-13
2115042-6	1990	Assay of insulin and glucagon in the islet monolayers revealed that IL-1, TNF, and IFN gamma inhibited both B- and A-cell secretory functions; however, only IL-1 and TNF produced permanent decreases in insulin and glucagon contents in the islet cultures.	Glucagon	21-29	interleukin 1 alpha	Homo sapiens	68-72
2167226-5	1990	Dibutyryl cyclic AMP, which is a cAMP analog able to penetrate into the cytosol, increased lymphocyte binding to the same extent as IL 1.	Bucladesine	0-20	interleukin 1 alpha	Homo sapiens	132-136
2167226-5	1990	Dibutyryl cyclic AMP, which is a cAMP analog able to penetrate into the cytosol, increased lymphocyte binding to the same extent as IL 1.	Cyclic AMP	33-37	interleukin 1 alpha	Homo sapiens	132-136
2167226-7	1990	IL 1 increased the level of cytosolic cAMP in a time- and dose-dependent manner measured with radioimmunoassay.	Cyclic AMP	38-42	interleukin 1 alpha	Homo sapiens	0-4
2167226-8	1990	2",5"-Dideoxyadenosine, which is an inhibitor of adenylate cyclase, decreased both the IL 1-induced lymphocyte binding to endothelial cells and elevation in cytosolic cAMP levels.	2',5'-dideoxyadenosine	0-22	interleukin 1 alpha	Homo sapiens	87-91
2167226-8	1990	2",5"-Dideoxyadenosine, which is an inhibitor of adenylate cyclase, decreased both the IL 1-induced lymphocyte binding to endothelial cells and elevation in cytosolic cAMP levels.	Cyclic AMP	167-171	interleukin 1 alpha	Homo sapiens	87-91
2167226-9	1990	Lymphocyte binding increased with cytosolic cAMP levels in accordance with elevation of IL 1 concentration.	Cyclic AMP	44-48	interleukin 1 alpha	Homo sapiens	88-92
2167226-10	1990	These results suggest that cAMP is essential in signal transduction during IL 1-induced lymphocyte binding to cultured endothelial cell monolayers.	Cyclic AMP	27-31	interleukin 1 alpha	Homo sapiens	75-79
2211341-1	1990	The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied.	Testosterone	87-99	interleukin 1 alpha	Homo sapiens	77-81
2211341-5	1990	Both TNF and IL-1 stimulated basal secretion of testosterone in whole testis cells, as well as purified Leydig cells.	Testosterone	48-60	interleukin 1 alpha	Homo sapiens	13-17
2211341-6	1990	Additionally, both TNF and IL-1 augmented maximally hCG stimulated testosterone secretion.	Testosterone	67-79	interleukin 1 alpha	Homo sapiens	27-31
2211341-9	1990	We have concluded from this data that TNF and IL-1 stimulate the testosterone secretion by adult rat Leydig cells.	Testosterone	65-77	interleukin 1 alpha	Homo sapiens	46-50
2115042-6	1990	Assay of insulin and glucagon in the islet monolayers revealed that IL-1, TNF, and IFN gamma inhibited both B- and A-cell secretory functions; however, only IL-1 and TNF produced permanent decreases in insulin and glucagon contents in the islet cultures.	Glucagon	214-222	interleukin 1 alpha	Homo sapiens	68-72
2115042-6	1990	Assay of insulin and glucagon in the islet monolayers revealed that IL-1, TNF, and IFN gamma inhibited both B- and A-cell secretory functions; however, only IL-1 and TNF produced permanent decreases in insulin and glucagon contents in the islet cultures.	Glucagon	214-222	interleukin 1 alpha	Homo sapiens	157-161
2141625-6	1990	Similar results were obtained with the D10 T cell clone; stimulation with Con A + interleukin 1 (IL-1), antigen-presenting cells (APC), or the clonotypic antibody + IL-1 was greatly reduced in the presence of antisense oligonucleotides to Ly-6.	Oligonucleotides	219-235	interleukin 1 alpha	Homo sapiens	165-169
2370292-8	1990	In IH subjects, significant correlations were found between IL-1 and hydroxyproline (r = 0.70; P less than 0.0001), IL-1 and quantitative computer tomography values (r = -0.49; P less than 0.005), and IL-1 and urinary calcium (r = -0.36; P less than 0.05).	Hydroxyproline	69-83	interleukin 1 alpha	Homo sapiens	60-64
2141625-6	1990	Similar results were obtained with the D10 T cell clone; stimulation with Con A + interleukin 1 (IL-1), antigen-presenting cells (APC), or the clonotypic antibody + IL-1 was greatly reduced in the presence of antisense oligonucleotides to Ly-6.	ly-6	239-243	interleukin 1 alpha	Homo sapiens	165-169
2162889-2	1990	The density of beta AR, assayed by 125I-pindolol binding, was increased two- to threefold by a 24-h incubation of the cells with IL-1 alpha, IL-1 beta, and TNF-alpha (EC50: 2.7, 8.2, and 24 pM, respectively), although a series of other cytokines and growth factors did not have this effect.	125i-pindolol	35-48	interleukin 1 alpha	Homo sapiens	129-139
2115174-1	1990	We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1 alpha) into mature IL-1 alpha.	Calcium	36-43	interleukin 1 alpha	Homo sapiens	173-192
2394932-2	1990	We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha.	Ibuprofen	47-61	interleukin 1 alpha	Homo sapiens	152-171
2178224-4	1990	We show that the phorbol ester-responsive element of the collagenase gene mediates both positive and negative regulatory effects, respectively, of IL-1 and RA on transcription.	Phorbol Esters	17-30	interleukin 1 alpha	Homo sapiens	147-151
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tretinoin	128-141	interleukin 1 alpha	Homo sapiens	26-30
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tretinoin	128-141	interleukin 1 alpha	Homo sapiens	151-155
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	160-197	interleukin 1 alpha	Homo sapiens	26-30
2115174-1	1990	We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1 alpha) into mature IL-1 alpha.	Calcium	36-43	interleukin 1 alpha	Homo sapiens	218-228
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	67-77
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	104-114
2115174-1	1990	We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1 alpha) into mature IL-1 alpha.	Calcium	36-43	interleukin 1 alpha	Homo sapiens	194-204
19256129-3	1990	In this review we refer to the interleukin-1, interleukin-6 and tumor necrosis factor because of their elevated basal levels in acute and chronic hepatopaties and in response to lipopolisacharide mainly in alcoholic liver disease.	lipopolisacharide	178-195	interleukin 1 alpha	Homo sapiens	31-44
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	104-114
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Ionomycin	18-27	interleukin 1 alpha	Homo sapiens	67-77
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Ionomycin	18-27	interleukin 1 alpha	Homo sapiens	104-114
2115174-2	1990	Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-1 alpha and the release of mature IL-1 alpha either from lipopolysaccharide (LPS)-activated human adherent mononuclear cells or from a human bladder carcinoma cell line (HTB9 5637) that constitutively produces human IL-1 alpha and -beta.	Ionomycin	18-27	interleukin 1 alpha	Homo sapiens	104-114
2115174-3	1990	The proteolytic processing of pre-IL-1 alpha was completely inhibited by EGTA.	Egtazic Acid	73-77	interleukin 1 alpha	Homo sapiens	34-44
2115174-4	1990	Similar calcium-dependent proteolytic processing of pre-IL-1 alpha was also observed with lysates of either LPS-activated human adherent mononuclear cells or HTB9 5637 cells.	Calcium	8-15	interleukin 1 alpha	Homo sapiens	56-66
2115174-7	1990	Taken together, these findings indicate that calcium-dependent proteolytic processing of pre-IL-1 alpha is selectively mediated by CANP.	Calcium	45-52	interleukin 1 alpha	Homo sapiens	93-103
2164143-1	1990	Interleukin-1 (IL-1) production by periodic acid (H5IO6)-oxidized human peripheral blood mononuclear (PBMN) cells was assessed by the thymocyte co-mitogenesis assay.	Periodic Acid	35-48	interleukin 1 alpha	Homo sapiens	0-13
2164143-1	1990	Interleukin-1 (IL-1) production by periodic acid (H5IO6)-oxidized human peripheral blood mononuclear (PBMN) cells was assessed by the thymocyte co-mitogenesis assay.	Periodic Acid	35-48	interleukin 1 alpha	Homo sapiens	15-19
2164143-1	1990	Interleukin-1 (IL-1) production by periodic acid (H5IO6)-oxidized human peripheral blood mononuclear (PBMN) cells was assessed by the thymocyte co-mitogenesis assay.	Periodic Acid	50-55	interleukin 1 alpha	Homo sapiens	0-13
2164143-1	1990	Interleukin-1 (IL-1) production by periodic acid (H5IO6)-oxidized human peripheral blood mononuclear (PBMN) cells was assessed by the thymocyte co-mitogenesis assay.	Periodic Acid	50-55	interleukin 1 alpha	Homo sapiens	15-19
2164143-3	1990	Thymocyte proliferation, driven by periodic acid-induced IL-1, was abolished by an antibody to IL-1 alpha and IL-1 beta.	Periodic Acid	35-48	interleukin 1 alpha	Homo sapiens	57-61
2164143-3	1990	Thymocyte proliferation, driven by periodic acid-induced IL-1, was abolished by an antibody to IL-1 alpha and IL-1 beta.	Periodic Acid	35-48	interleukin 1 alpha	Homo sapiens	95-105
2164143-5	1990	Partial characterization of H5IO6-induced IL-1 beta indicated that it was identical to IL-1 produced by lipopolysaccharide-stimulated macrophages.	Periodic Acid	28-33	interleukin 1 alpha	Homo sapiens	42-46
2164143-6	1990	It is concluded that oxidation of human PBMN cells by H5IO6 triggers synthesis and release of IL-1, most of which was in its IL-1 beta form.	Periodic Acid	54-59	interleukin 1 alpha	Homo sapiens	94-98
2357222-1	1990	Using hepatocytes in suspension, freshly isolated from adult male fed rats, we studied the acute influence of recombinant human interleukins 1 alpha, 2 and 6 on glycogen and fatty acid metabolism.	Glycogen	161-169	interleukin 1 alpha	Homo sapiens	128-157
2357213-1	1990	The objective of this work was to investigate the role of leukotrienes in the production of IL-1 by activated human peripheral blood monocytes and mouse peritoneal macrophages.	Leukotrienes	58-70	interleukin 1 alpha	Homo sapiens	92-96
2357222-1	1990	Using hepatocytes in suspension, freshly isolated from adult male fed rats, we studied the acute influence of recombinant human interleukins 1 alpha, 2 and 6 on glycogen and fatty acid metabolism.	Fatty Acids	174-184	interleukin 1 alpha	Homo sapiens	128-157
2357213-2	1990	Using overnight adherent macrophages, stimulation with lipopolysaccharide or zymosan caused a time-dependent increase in IL-1 production.	Zymosan	77-84	interleukin 1 alpha	Homo sapiens	121-125
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Cycloheximide	124-137	interleukin 1 alpha	Homo sapiens	242-252
2357213-3	1990	LTC4 was detected and preceded IL-1 production only in zymosan-treated macrophages.	Zymosan	55-62	interleukin 1 alpha	Homo sapiens	31-35
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Dactinomycin	142-155	interleukin 1 alpha	Homo sapiens	242-252
2114929-4	1990	An increase in release of interleukin 1 by keratinocytes was detected following culture for 24 h with a Ni2+ concentration of 2.3-11.5 micrograms/ml.	Nickel(2+)	104-108	interleukin 1 alpha	Homo sapiens	26-39
2160861-0	1990	Quinolone-induced differential modification of IL-1 alpha and IL-1 beta production by LPS-stimulated human monocytes.	Quinolones	0-9	interleukin 1 alpha	Homo sapiens	47-57
2160861-3	1990	Cip had a post-transcriptional differential effect on the production of IL-1 alpha and IL-1 beta, reducing the total amount of IL-1 beta produced by LPS-stimulated monocytes, while that of IL-1 alpha was unaffected.	Ciprofloxacin	0-3	interleukin 1 alpha	Homo sapiens	72-82
2160861-6	1990	Cip is, to our knowledge, the first pharmacological agent found to have a differential effect on the synthesis of IL-1 alpha and IL-1 beta.	Ciprofloxacin	0-3	interleukin 1 alpha	Homo sapiens	114-124
1972149-6	1990	On the other hand interleukin 1 alpha increases binding within 4 hr and operates via cAMP but not via protein kinase C. These results imply that different mediators of inflammation can activate different signal transduction pathways but lead to similar increases in lymphocyte binding.	Cyclic AMP	85-89	interleukin 1 alpha	Homo sapiens	18-37
2379873-7	1990	Prednisolone inhibited interleukin 1 release in a dose dependent fashion.	Prednisolone	0-12	interleukin 1 alpha	Homo sapiens	23-36
2168857-0	1990	An interleukin 1 inhibitor affects both cell-associated interleukin 1-induced T cell proliferation and PGE2/collagenase production by human dermal fibroblasts and synovial cells.	Dinoprostone	103-107	interleukin 1 alpha	Homo sapiens	3-16
2168857-2	1990	Demonstration of cell-associated IL 1 activity was based on the ability of LPS-treated U937 cells, subsequently fixed with paraformaldehyde, to stimulate thymocyte proliferation in the presence of phytohemagglutinin.	paraform	123-139	interleukin 1 alpha	Homo sapiens	33-37
2168857-6	1990	Data demonstrate that the IL 1 INH also blocks cell-associated IL 1-induced T cell proliferation and PGE2 production by both dermal fibroblasts and synovial cells as well as collagenase production by the latter cell type.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	26-30
2168857-6	1990	Data demonstrate that the IL 1 INH also blocks cell-associated IL 1-induced T cell proliferation and PGE2 production by both dermal fibroblasts and synovial cells as well as collagenase production by the latter cell type.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	63-67
2114298-6	1990	The effects of IL-1 were inhibited by removal of Cl- from the bathing solutions, or by indomethacin or piroxicam.	Indomethacin	87-99	interleukin 1 alpha	Homo sapiens	15-19
1695911-4	1990	IL-1 production in response to lipopolysaccharide was significantly lower in LL, BL, BB, and BT patients than in normal controls.	boeravinone B	85-87	interleukin 1 alpha	Homo sapiens	0-4
2112152-3	1990	IL-1 alpha and IL-1 beta inhibited 125I incorporation and [125I]iodothyronine release in a concentration-dependent manner.	Iodine-125	35-39	interleukin 1 alpha	Homo sapiens	0-10
2112152-3	1990	IL-1 alpha and IL-1 beta inhibited 125I incorporation and [125I]iodothyronine release in a concentration-dependent manner.	iodothyronine	64-77	interleukin 1 alpha	Homo sapiens	0-10
2114298-6	1990	The effects of IL-1 were inhibited by removal of Cl- from the bathing solutions, or by indomethacin or piroxicam.	Piroxicam	103-112	interleukin 1 alpha	Homo sapiens	15-19
2161351-1	1990	We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha).	Dinoprostone	55-59	interleukin 1 alpha	Homo sapiens	200-219
2161351-1	1990	We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha).	Dinoprostone	37-53	interleukin 1 alpha	Homo sapiens	200-219
2161351-2	1990	The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH.	Indomethacin	138-150	interleukin 1 alpha	Homo sapiens	81-91
2161351-2	1990	The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH.	Dinoprostone	191-195	interleukin 1 alpha	Homo sapiens	81-91
2109093-0	1990	Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.	Nitrogen Oxides	31-46	interleukin 1 alpha	Homo sapiens	122-135
2109093-5	1990	Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide.	Nitrites	147-155	interleukin 1 alpha	Homo sapiens	61-74
2109093-4	1990	In this study, we tested interferon gamma, tumor necrosis factor, interleukin-1, interleukin-2, muramyl dipeptide, and endotoxin for their effects on production of nitrogen oxides by endothelial cells.	Nitrogen Oxides	164-179	interleukin 1 alpha	Homo sapiens	66-79
2383221-6	1990	Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin.	Indomethacin	102-114	interleukin 1 alpha	Homo sapiens	39-52
2383221-6	1990	Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin.	Indomethacin	102-114	interleukin 1 alpha	Homo sapiens	185-198
2383221-6	1990	Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin.	Indomethacin	218-230	interleukin 1 alpha	Homo sapiens	39-52
2383221-6	1990	Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin.	Indomethacin	218-230	interleukin 1 alpha	Homo sapiens	185-198
2104222-2	1990	Further characterization of the plasma immunoreactive forms of IL 1 was done using Sephadex G-75 chromatography and TSKG2000 high performance gel permeation chromatography.	sephadex	83-96	interleukin 1 alpha	Homo sapiens	63-67
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	Dinoprostone	40-56	interleukin 1 alpha	Homo sapiens	199-209
1694134-1	1990	Serum-free culture of human monocytes in the presence of monoclonal antibodies to the LFA-1 alpha chain (CD11a), CR3 alpha chain (CD11b) or beta chain (CD18) bound to Sepharose induced the dose-dependent production of cell-associated interleukin (IL) 1 activity and of IL 1 alpha and IL 1 beta antigens, but no release of extracellular IL 1 activity or antigen in the culture medium.	Sepharose	167-176	interleukin 1 alpha	Homo sapiens	269-279
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	dibutyryl	102-111	interleukin 1 alpha	Homo sapiens	199-209
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	1-Methyl-3-isobutylxanthine	121-149	interleukin 1 alpha	Homo sapiens	199-209
1716487-8	1990	These results demonstrate that IL 6, TNF alpha, IL 1 alpha and IL 1 beta production can be differently modulated by an agent, PGE2, which is produced simultaneously by LPS-stimulated monocytes.	Dinoprostone	126-130	interleukin 1 alpha	Homo sapiens	48-58
1694134-1	1990	Serum-free culture of human monocytes in the presence of monoclonal antibodies to the LFA-1 alpha chain (CD11a), CR3 alpha chain (CD11b) or beta chain (CD18) bound to Sepharose induced the dose-dependent production of cell-associated interleukin (IL) 1 activity and of IL 1 alpha and IL 1 beta antigens, but no release of extracellular IL 1 activity or antigen in the culture medium.	Sepharose	167-176	interleukin 1 alpha	Homo sapiens	269-273
1694134-6	1990	The lack of induction of IL 1 release by stimulation of the CD11/CD18 molecules resembled the intracellular accumulation of IL 1 induced by lipid A.	Lipid A	140-147	interleukin 1 alpha	Homo sapiens	124-128
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	0-18	interleukin 1 alpha	Homo sapiens	216-236
2162329-3	1990	However, some of the opioids potentiated IL-1 production and release in macrophages concomitantly stimulated by lipopolysaccharide (LPS) or silica.	Silicon Dioxide	140-146	interleukin 1 alpha	Homo sapiens	41-45
2162329-4	1990	LPS induced predominantly intracellular IL-1 activity, whereas most of the silica-induced IL-1 was released extracellularly.	Silicon Dioxide	75-81	interleukin 1 alpha	Homo sapiens	90-94
2162329-5	1990	beta-Endorphin, leucine-enkephalin (leu-enkephalin) and beta-neoendorphin all potentiated both intracellular and extracellular release of IL 1 induced by either LPS or silica.	Silicon Dioxide	168-174	interleukin 1 alpha	Homo sapiens	138-142
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	20-22	interleukin 1 alpha	Homo sapiens	216-236
2162329-7	1990	The potentiating effects of beta-endorphin on LPS-induced IL-1 production/secretion were inhibited by naloxone, pointing to an involvement of opioid receptors.	Naloxone	102-110	interleukin 1 alpha	Homo sapiens	58-62
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	119-121	interleukin 1 alpha	Homo sapiens	216-236
2332736-4	1990	IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1.	Indomethacin	57-69	interleukin 1 alpha	Homo sapiens	145-149
2139669-6	1990	The recombinant IL-1ra also blocks IL-1 alpha and IL-1 beta stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes, and of collagenase production by the synovial cells.	Dinoprostone	75-79	interleukin 1 alpha	Homo sapiens	35-45
2398032-0	1990	Calcium-dependent binding of phosphorylated human pre interleukin 1 alpha to phospholipids.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	54-73
2398032-0	1990	Calcium-dependent binding of phosphorylated human pre interleukin 1 alpha to phospholipids.	Phospholipids	77-90	interleukin 1 alpha	Homo sapiens	54-73
2398032-1	1990	The effect of phosphorylation of pre interleukin 1 alpha (IL 1 alpha) on its association with various phospholipids was investigated.	Phospholipids	102-115	interleukin 1 alpha	Homo sapiens	37-56
2398032-1	1990	The effect of phosphorylation of pre interleukin 1 alpha (IL 1 alpha) on its association with various phospholipids was investigated.	Phospholipids	102-115	interleukin 1 alpha	Homo sapiens	58-68
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phospholipids	68-81	interleukin 1 alpha	Homo sapiens	29-39
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidic Acids	92-109	interleukin 1 alpha	Homo sapiens	29-39
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidylserines	111-129	interleukin 1 alpha	Homo sapiens	29-39
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidylinositols	135-155	interleukin 1 alpha	Homo sapiens	29-39
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidylcholines	189-208	interleukin 1 alpha	Homo sapiens	29-39
2184672-5	1990	One of these monokines, interleukin 1, induces a natriuresis by direct inhibition of collecting duct sodium reabsorption.	Sodium	101-107	interleukin 1 alpha	Homo sapiens	24-37
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	phosphatidylethanolamine	213-237	interleukin 1 alpha	Homo sapiens	29-39
2398032-5	1990	In order to obtain half-maximal binding of pre IL 1 alpha to phosphatidic acid or phosphatidylserine, Ca2+ between 5 and 100 microM was required.	Phosphatidic Acids	61-78	interleukin 1 alpha	Homo sapiens	47-57
2398032-5	1990	In order to obtain half-maximal binding of pre IL 1 alpha to phosphatidic acid or phosphatidylserine, Ca2+ between 5 and 100 microM was required.	Phosphatidylserines	82-100	interleukin 1 alpha	Homo sapiens	47-57
2398032-7	1990	Phosphorylated pre IL 1 alpha did not bind to intact peripheral blood mononuclear cells irrespective of lipopolysaccharide stimulation, but did bind to membrane vesicles prepared from these cells in the presence of calcium.	Calcium	215-222	interleukin 1 alpha	Homo sapiens	19-29
2398032-9	1990	Taken together, these data suggest that phosphorylated pre IL 1 alpha binds to the inner surface of plasma membrane in a Ca2(+)- and phospholipid-dependent manner.	Phospholipids	133-145	interleukin 1 alpha	Homo sapiens	59-69
2138518-1	1990	Serotonin (10(-4) - 10(-7) M) augmented natural killer cell cytotoxicity (NKCC) of human CD16+/non-T lymphocytes in vitro against the NK-sensitive target cells K 562 erythroleukemic, Molt-4 lymphoma, Chang liver cells, and against EBV-transformed Daudi B-lymphoblastoid target cells by a mechanism of action involving a prostaglandin-and IL-1-independent accessory function of monocytes.	Serotonin	0-9	interleukin 1 alpha	Homo sapiens	338-342
1695452-4	1990	IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls.	Histamine	120-129	interleukin 1 alpha	Homo sapiens	0-10
2331029-2	1990	At rest and at a neutral ambient temperature (Ta) of 24 degrees C, intravenous injection of recombinant human interleukin 1 (IL-1, 40 micrograms/kg) produced a 0.5 degree C rise in rectal temperature (Tre) from 37.4 degrees C. At Ta of 34 degrees C, at which Tre was 38.6 degrees C, Tre rise in response to IL-1 was only 0.2 degree C greater than when saline was used.	Sodium Chloride	352-358	interleukin 1 alpha	Homo sapiens	110-129
2378930-2	1990	IL-1 alpha increased progesterone secretion by preovulatory follicles during a 24-h incubation in RPMI-1640 medium containing hCG (100 mIU/ml) (progesterone levels: 17.5 +/- 2.2 vs. 10.6 +/- 1.9 ng/follicle/ml, p less than 0.05).	Progesterone	21-33	interleukin 1 alpha	Homo sapiens	0-10
2378930-5	1990	IL-1 alpha also stimulated production of testosterone in thecae of preovulatory follicles.	Testosterone	41-53	interleukin 1 alpha	Homo sapiens	0-10
2378930-7	1990	IL-1 alpha at 5-50 U/ml maximally stimulated progesterone production in the preovulatory follicles, and no significant effect of IL-1 alpha was observed until the 12th hour of incubation.	Progesterone	45-57	interleukin 1 alpha	Homo sapiens	0-10
2378930-9	1990	IL-1 alpha in the presence of hCG also significantly increased progesterone secretion by atretic preovulatory follicles.	Progesterone	63-75	interleukin 1 alpha	Homo sapiens	0-10
2189790-0	1990	Secretion of N-glycosylated human recombinant interleukin-1 alpha in Saccharomyces cerevisiae.	Nitrogen	13-14	interleukin 1 alpha	Homo sapiens	46-65
2189790-3	1990	Translational fusions to either one of three yeast signal sequences resulted in secretion of bioactive, N-glycosylated hIL-1 alpha.	Nitrogen	104-105	interleukin 1 alpha	Homo sapiens	119-130
2159204-2	1990	A stimulatory effect on [125I] iodide incorporation into protein (iodination) was seen in cultures exposed to human recombinant interleukin 1 alpha (20 micrograms/l) for 1 h and (0.1 or 10 micrograms/l) for 18 h, whereas an inhibitory effect on iodination of interleukin 1 (10 micrograms/l) was registered after pre-incubation for 42 h and significant upon stimulation with TSH (200 mU/l).	[125i] iodide	24-37	interleukin 1 alpha	Homo sapiens	128-147
2159204-2	1990	A stimulatory effect on [125I] iodide incorporation into protein (iodination) was seen in cultures exposed to human recombinant interleukin 1 alpha (20 micrograms/l) for 1 h and (0.1 or 10 micrograms/l) for 18 h, whereas an inhibitory effect on iodination of interleukin 1 (10 micrograms/l) was registered after pre-incubation for 42 h and significant upon stimulation with TSH (200 mU/l).	[125i] iodide	24-37	interleukin 1 alpha	Homo sapiens	128-141
2159204-2	1990	A stimulatory effect on [125I] iodide incorporation into protein (iodination) was seen in cultures exposed to human recombinant interleukin 1 alpha (20 micrograms/l) for 1 h and (0.1 or 10 micrograms/l) for 18 h, whereas an inhibitory effect on iodination of interleukin 1 (10 micrograms/l) was registered after pre-incubation for 42 h and significant upon stimulation with TSH (200 mU/l).	Thyrotropin	374-377	interleukin 1 alpha	Homo sapiens	128-147
2159204-2	1990	A stimulatory effect on [125I] iodide incorporation into protein (iodination) was seen in cultures exposed to human recombinant interleukin 1 alpha (20 micrograms/l) for 1 h and (0.1 or 10 micrograms/l) for 18 h, whereas an inhibitory effect on iodination of interleukin 1 (10 micrograms/l) was registered after pre-incubation for 42 h and significant upon stimulation with TSH (200 mU/l).	Thyrotropin	374-377	interleukin 1 alpha	Homo sapiens	128-141
2159204-3	1990	Cyclic AMP levels were stimulated in cells exposed to interleukin 1, however, significantly only after 42 h of pre-incubation, whereas TSH-stimulated cAMP response was inhibited by interleukin 1 already after 18 h of pre-incubation.	Cyclic AMP	0-10	interleukin 1 alpha	Homo sapiens	54-67
2159204-3	1990	Cyclic AMP levels were stimulated in cells exposed to interleukin 1, however, significantly only after 42 h of pre-incubation, whereas TSH-stimulated cAMP response was inhibited by interleukin 1 already after 18 h of pre-incubation.	Thyrotropin	135-138	interleukin 1 alpha	Homo sapiens	181-194
2159204-3	1990	Cyclic AMP levels were stimulated in cells exposed to interleukin 1, however, significantly only after 42 h of pre-incubation, whereas TSH-stimulated cAMP response was inhibited by interleukin 1 already after 18 h of pre-incubation.	Cyclic AMP	150-154	interleukin 1 alpha	Homo sapiens	181-194
2138628-0	1990	Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production.	Dinoprostone	121-137	interleukin 1 alpha	Homo sapiens	0-13
2346722-2	1990	Recombinant human (rh) IL-1 alpha, IL-1 beta and TNF-alpha augmented production of IL-6 in human MC.	Methylcholanthrene	97-99	interleukin 1 alpha	Homo sapiens	23-33
2346722-6	1990	IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines.	Tritium	45-47	interleukin 1 alpha	Homo sapiens	0-10
2346722-6	1990	IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines.	Methylcholanthrene	186-188	interleukin 1 alpha	Homo sapiens	0-10
2180683-3	1990	We have examined the effects of human recombinant IL-1 (alpha- and beta-subtypes) on LH release in vivo and hypothalamic LHRH release in vitro.	Luteinizing Hormone	85-87	interleukin 1 alpha	Homo sapiens	50-54
2180683-13	1990	These results demonstrated an overall inhibitory effect of icv IL-1 on the LHRH-LH axis and suggest that suppression of the steroid-induced LH surge by IL-1 may primarily be due to inhibition of LHRH release at hypothalamic sites located within the blood-brain barrier.	Steroids	124-131	interleukin 1 alpha	Homo sapiens	63-67
2180683-13	1990	These results demonstrated an overall inhibitory effect of icv IL-1 on the LHRH-LH axis and suggest that suppression of the steroid-induced LH surge by IL-1 may primarily be due to inhibition of LHRH release at hypothalamic sites located within the blood-brain barrier.	Steroids	124-131	interleukin 1 alpha	Homo sapiens	152-156
1690981-1	1990	Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus.	ethylenevinylacetate copolymer	32-40	interleukin 1 alpha	Homo sapiens	0-13
1690981-1	1990	Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus.	ethylenevinylacetate copolymer	42-74	interleukin 1 alpha	Homo sapiens	0-13
1690981-1	1990	Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus.	vinyl acetate	51-64	interleukin 1 alpha	Homo sapiens	0-13
2139599-2	1990	Culture supernatants from cryopreserved cells contained significantly larger concentrations of IL-1 [MNCs, 211 +/- 50; ACs, 640 +/- 41; NACs, 116 +/- 19 U/ml (mean +/- SEM)] as compared with supernatants from fresh cells (69 +/- 22, 427 +/- 69, and 72 +/- 33 U/ml, respectively).	nacs	136-140	interleukin 1 alpha	Homo sapiens	95-99
2157662-4	1990	Using an [35S]methionine-labeled preparation, specific binding of IL-1 to PMNs was demonstrated.	Sulfur-35	10-13	interleukin 1 alpha	Homo sapiens	66-70
2157662-4	1990	Using an [35S]methionine-labeled preparation, specific binding of IL-1 to PMNs was demonstrated.	Methionine	14-24	interleukin 1 alpha	Homo sapiens	66-70
2157662-6	1990	As IL-1 frequently activates arachidonic acid metabolism in other cell types, we investigated eicosanoid production as a putative consequence of the IL-1-PMN interaction.	Arachidonic Acid	29-45	interleukin 1 alpha	Homo sapiens	3-7
2157662-6	1990	As IL-1 frequently activates arachidonic acid metabolism in other cell types, we investigated eicosanoid production as a putative consequence of the IL-1-PMN interaction.	Eicosanoids	94-104	interleukin 1 alpha	Homo sapiens	149-153
2157662-7	1990	HPLC analysis of extracted supernatants of IL-1-treated PMNs demonstrated the release of leukotriene B4 (LTB4), its oxidative products, and 5-hydroxyeicosatetraenoic acid (5-HETE).	Leukotriene B4	89-103	interleukin 1 alpha	Homo sapiens	43-47
2157662-7	1990	HPLC analysis of extracted supernatants of IL-1-treated PMNs demonstrated the release of leukotriene B4 (LTB4), its oxidative products, and 5-hydroxyeicosatetraenoic acid (5-HETE).	5-hydroxy-6,8,11,14-eicosatetraenoic acid	140-170	interleukin 1 alpha	Homo sapiens	43-47
2157662-7	1990	HPLC analysis of extracted supernatants of IL-1-treated PMNs demonstrated the release of leukotriene B4 (LTB4), its oxidative products, and 5-hydroxyeicosatetraenoic acid (5-HETE).	5-hydroxy-6,8,11,14-eicosatetraenoic acid	172-178	interleukin 1 alpha	Homo sapiens	43-47
2157662-10	1990	In time-course studies, it was shown that maximal eicosanoid secretion required a 30-min incubation with IL-1.	Eicosanoids	50-60	interleukin 1 alpha	Homo sapiens	105-109
2138628-0	1990	Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production.	Dinoprostone	121-137	interleukin 1 alpha	Homo sapiens	15-19
2138628-0	1990	Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production.	Dinoprostone	121-137	interleukin 1 alpha	Homo sapiens	75-79
2138628-0	1990	Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production.	Dinoprostone	121-137	interleukin 1 alpha	Homo sapiens	75-79
2138628-2	1990	In this study, the ability of the purified E. coli-derived recombinant interleukin-1 alpha (rIL-1 alpha) to regulate the production of PGE2 by the endometrial epithelium is investigated.	Dinoprostone	135-139	interleukin 1 alpha	Homo sapiens	71-84
2138628-10	1990	Experiments using radioiodinated rIL-1 alpha reveal that the membranes prepared from human endometrial epithelium possess high affinity receptors for IL-1, suggesting that IL-1 regulates PGE2 synthesis by binding to this receptor site.	Dinoprostone	187-191	interleukin 1 alpha	Homo sapiens	150-154
2138628-11	1990	The expression of IL-1 receptors and the ability to modulate PGE2 production by IL-1 in endometrial epithelium suggest that IL-1 may play a significant role in human uterine function via modulation of PGE2 production.	Dinoprostone	61-65	interleukin 1 alpha	Homo sapiens	80-84
2138628-11	1990	The expression of IL-1 receptors and the ability to modulate PGE2 production by IL-1 in endometrial epithelium suggest that IL-1 may play a significant role in human uterine function via modulation of PGE2 production.	Dinoprostone	61-65	interleukin 1 alpha	Homo sapiens	80-84
2138628-11	1990	The expression of IL-1 receptors and the ability to modulate PGE2 production by IL-1 in endometrial epithelium suggest that IL-1 may play a significant role in human uterine function via modulation of PGE2 production.	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	18-22
2138628-11	1990	The expression of IL-1 receptors and the ability to modulate PGE2 production by IL-1 in endometrial epithelium suggest that IL-1 may play a significant role in human uterine function via modulation of PGE2 production.	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	80-84
2138628-11	1990	The expression of IL-1 receptors and the ability to modulate PGE2 production by IL-1 in endometrial epithelium suggest that IL-1 may play a significant role in human uterine function via modulation of PGE2 production.	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	80-84
2157429-0	1990	IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP.	Cyclic AMP	138-142	interleukin 1 alpha	Homo sapiens	0-3
2182947-5	1990	The use of antisense phosphorothioate oligonucleotides to inhibit IL1 production should enable the complex pathways of IL1 regulation to be elucidated and provide information on the biological role of these cytokines.	Phosphorothioate Oligonucleotides	21-54	interleukin 1 alpha	Homo sapiens	66-69
2182947-5	1990	The use of antisense phosphorothioate oligonucleotides to inhibit IL1 production should enable the complex pathways of IL1 regulation to be elucidated and provide information on the biological role of these cytokines.	Phosphorothioate Oligonucleotides	21-54	interleukin 1 alpha	Homo sapiens	119-122
2165582-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)--stimulated human monocytes, interleukin-1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	quinoline	136-145	interleukin 1 alpha	Homo sapiens	90-103
2165582-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)--stimulated human monocytes, interleukin-1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	quinoline	136-145	interleukin 1 alpha	Homo sapiens	105-109
2165582-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)--stimulated human monocytes, interleukin-1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	Quinolones	170-180	interleukin 1 alpha	Homo sapiens	90-103
2165582-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)--stimulated human monocytes, interleukin-1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	Quinolones	170-180	interleukin 1 alpha	Homo sapiens	105-109
2165582-4	1990	These quinolones were found to decrease extracellular TNF production in a dose-dependent manner at concentrations higher than 25 micrograms/ml as previously described by our laboratory with regard to IL-1 production.	Quinolones	6-16	interleukin 1 alpha	Homo sapiens	200-204
2165582-8	1990	Furthermore, the quinolone-induced accumulation of intracellular cAMP could explain the extracellular decrease in both IL-1 and TNF production.	Quinolones	17-26	interleukin 1 alpha	Homo sapiens	119-123
2165582-8	1990	Furthermore, the quinolone-induced accumulation of intracellular cAMP could explain the extracellular decrease in both IL-1 and TNF production.	Cyclic AMP	65-69	interleukin 1 alpha	Homo sapiens	119-123
2157429-2	1990	IL1 itself raised neither the cAMP level nor the intracellular Ca2+ level nor did it induce phosphatidylinositol (PI) breakdown.	Phosphatidylinositols	92-112	interleukin 1 alpha	Homo sapiens	0-3
2157429-4	1990	Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less.	Cyclic AMP	23-27	interleukin 1 alpha	Homo sapiens	62-65
2157429-4	1990	Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less.	Cyclic AMP	37-41	interleukin 1 alpha	Homo sapiens	62-65
2157429-5	1990	Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation.	Cyclic AMP	9-13	interleukin 1 alpha	Homo sapiens	95-98
2157429-5	1990	Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation.	Cyclic AMP	58-62	interleukin 1 alpha	Homo sapiens	95-98
2102362-2	1990	In particular, fixation of IL-1-expressing cells for 15 min in 1% paraformaldehyde (PFA) is commonly used to evidence such "membrane-associated" IL-1 activity but other authors have attributed this to passive leakage of IL-1 alpha from the cells and report no activity with longer fixation times.	paraform	66-82	interleukin 1 alpha	Homo sapiens	220-230
2310781-0	1990	Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor.	Dinoprostone	33-49	interleukin 1 alpha	Homo sapiens	82-122
2310781-3	1990	Of the cytokines tested, interleukin-1 (IL-1; alpha and beta forms) consistently induced the highest levels of PGE2 production followed, to a lesser extent, by tumour necrosis factor (TNF; alpha and beta forms).	Dinoprostone	111-115	interleukin 1 alpha	Homo sapiens	25-38
2310781-3	1990	Of the cytokines tested, interleukin-1 (IL-1; alpha and beta forms) consistently induced the highest levels of PGE2 production followed, to a lesser extent, by tumour necrosis factor (TNF; alpha and beta forms).	Dinoprostone	111-115	interleukin 1 alpha	Homo sapiens	40-51
2310781-4	1990	The IL-1s were effective at concentrations 2-3 orders of magnitude less than the TNFs, with each cytokine demonstrating a dose-dependent increase in PGE2 synthesis for the two culture procedures.	Dinoprostone	149-153	interleukin 1 alpha	Homo sapiens	4-8
2310781-5	1990	The increased PGE2 production by the chondrocytes exhibited a lag phase of 4-8 h following the addition of the IL-1 or TNF and was inhibited by actinomycin D and cycloheximide, indicating a requirement for de novo RNA and protein synthesis, respectively.	Dinoprostone	14-18	interleukin 1 alpha	Homo sapiens	111-115
2310781-6	1990	Our results suggest that IL-1 may be the key cytokine involved in modulating chondrocyte PGE2 production in inflammatory arthritis; they further extend the list of human chondrocyte responses which are affected by both IL-1 and TNF.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	25-29
2160190-5	1990	IL-1 production in monocytes was reported to be partly dependent on cytosolic free calcium.	Calcium	83-90	interleukin 1 alpha	Homo sapiens	0-4
2160190-6	1990	These results, therefore, may indicate that the different activity between LTB4 and LTB5 in the enhancement of IL-1-like activity could be partly ascribed to the different potency in inducing calcium mobilization between LTB4 and LTB5 in human blood monocytes.	Calcium	192-199	interleukin 1 alpha	Homo sapiens	111-115
2350446-0	1990	Zidovudine inhibits functional extracellular monocytic interleukin-1.	Zidovudine	0-10	interleukin 1 alpha	Homo sapiens	55-68
2350446-3	1990	The present study demonstrates that zidovudine inhibits the extracellular release of IL-1 activity without affecting the generation of intracellular IL-1 or the amount of released IL-1 beta protein.	Zidovudine	36-46	interleukin 1 alpha	Homo sapiens	85-89
2350446-5	1990	Since IL-1 may upregulate the expression of HIV genes in infected cells, the inhibitory effect of zidovudine on the release of functional IL-1 may be relevant for the beneficial effect of the drug in HIV infection.	Zidovudine	98-108	interleukin 1 alpha	Homo sapiens	138-142
2104217-6	1990	The IL 1 inhibitor activity was induced by rhGM-CSF with a D50 around 40 pg/ml.	Pyrazinamide	59-62	interleukin 1 alpha	Homo sapiens	4-8
2104217-8	1990	The specific binding of biosynthetically labeled IL 1 inhibitor to target cells (EL-4.6.1C10) showed a protein of 26 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	138-160	interleukin 1 alpha	Homo sapiens	49-53
2104217-8	1990	The specific binding of biosynthetically labeled IL 1 inhibitor to target cells (EL-4.6.1C10) showed a protein of 26 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	polyacrylamide	161-175	interleukin 1 alpha	Homo sapiens	49-53
2104217-8	1990	The specific binding of biosynthetically labeled IL 1 inhibitor to target cells (EL-4.6.1C10) showed a protein of 26 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	197-200	interleukin 1 alpha	Homo sapiens	49-53
2102362-2	1990	In particular, fixation of IL-1-expressing cells for 15 min in 1% paraformaldehyde (PFA) is commonly used to evidence such "membrane-associated" IL-1 activity but other authors have attributed this to passive leakage of IL-1 alpha from the cells and report no activity with longer fixation times.	paraform	84-87	interleukin 1 alpha	Homo sapiens	220-230
2102362-5	1990	This activity was independent of the duration of PFA fixation and was inhibited by anti-IL-1 alpha but not anti-IL-1 beta antibodies.	paraform	49-52	interleukin 1 alpha	Homo sapiens	88-98
2325034-2	1990	Interleukin-1 (IL-1) is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammation mediator.	Prostaglandins	47-60	interleukin 1 alpha	Homo sapiens	0-13
2106495-6	1990	In contrast to the dual effects of pyocyanine on lymphocyte response, lipopolysaccharide-induced IL-1 and tumor necrosis factor release by monocytes was markedly enhanced by low as well as high concentrations of pyocyanine.	Pyocyanine	212-222	interleukin 1 alpha	Homo sapiens	97-101
2312718-2	1990	We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects seen when bones are treated with hormones such as parathyroid hormone (PTH) and interleukin 1 (IL-1).	Oxygen	36-42	interleukin 1 alpha	Homo sapiens	269-288
2312718-2	1990	We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects seen when bones are treated with hormones such as parathyroid hormone (PTH) and interleukin 1 (IL-1).	derived free radicals	43-64	interleukin 1 alpha	Homo sapiens	269-288
2312718-4	1990	PTH and IL-1-stimulated bone resorption was inhibited by both natural and recombinant superoxide dismutase, an enzyme that depletes tissues of superoxide anions.	Superoxides	143-160	interleukin 1 alpha	Homo sapiens	8-12
2155785-9	1990	However, if GTP is added to the binding reactions the intensity of bands formed by extracts from control cells is strongly reduced, whereas extracts from IL1 treated cells form a single retarded complex that co-migrates with NF-kappa B from a pre-B cell line.	Guanosine Triphosphate	12-15	interleukin 1 alpha	Homo sapiens	154-157
2325034-2	1990	Interleukin-1 (IL-1) is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammation mediator.	Prostaglandins	47-60	interleukin 1 alpha	Homo sapiens	15-19
2407240-0	1990	Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes.	Dinoprostone	43-59	interleukin 1 alpha	Homo sapiens	63-76
2330345-4	1990	IL-1 increased PGE2 release (+44% at 5 U/ml), but did not greatly affect proteolysis.	Dinoprostone	15-19	interleukin 1 alpha	Homo sapiens	0-4
2407240-5	1990	Using an antiserum to interleukin 6 we have demonstrated that the production of prostaglandin E2 under basal conditions and in response to interleukin 1 is probably not mediated by interleukin 6.	Dinoprostone	80-96	interleukin 1 alpha	Homo sapiens	139-152
2330842-0	1990	Role of endogenous prostaglandin E2 in interleukin 1 production by peripheral blood monocytes from patients with rheumatoid arthritis.	Dinoprostone	19-35	interleukin 1 alpha	Homo sapiens	39-52
2330842-1	1990	We studied the effect of endogenous prostaglandin E2 (PGE2) on interleukin 1 (IL-1) production by peripheral blood monocytes from patients with rheumatoid arthritis (RA).	Dinoprostone	36-52	interleukin 1 alpha	Homo sapiens	63-82
2330842-1	1990	We studied the effect of endogenous prostaglandin E2 (PGE2) on interleukin 1 (IL-1) production by peripheral blood monocytes from patients with rheumatoid arthritis (RA).	Dinoprostone	54-58	interleukin 1 alpha	Homo sapiens	63-82
2330842-3	1990	However, IL-1 production by LPS-stimulated monocytes from RA patients cultured in medium containing indomethacin, an inhibitor of PGE2 synthesis, was significantly greater than that of monocytes from normal controls.	Indomethacin	100-112	interleukin 1 alpha	Homo sapiens	9-13
2330842-3	1990	However, IL-1 production by LPS-stimulated monocytes from RA patients cultured in medium containing indomethacin, an inhibitor of PGE2 synthesis, was significantly greater than that of monocytes from normal controls.	Dinoprostone	130-134	interleukin 1 alpha	Homo sapiens	9-13
2330842-6	1990	These results indicated that peripheral blood monocytes from RA patients could produce IL-1 in excess in vitro, but that in vivo IL-1 production by RA monocytes and IL-2 induction by RA T cells might be negatively regulated by endogenous PGE2.	Dinoprostone	238-242	interleukin 1 alpha	Homo sapiens	129-133
2297791-5	1990	The active phorbol esters synergized also with interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF alpha) in Tac expression.	Phorbol Esters	11-25	interleukin 1 alpha	Homo sapiens	62-66
2107866-2	1990	Human recombinant interleukin 1 alpha and lipopolysaccharide induced a concentration- and time-dependent release of prostaglandin E2, but not prostacyclin, from cultured neonatal and adult human dermal microvascular endothelial cells.	Dinoprostone	116-132	interleukin 1 alpha	Homo sapiens	18-37
2107866-3	1990	Prostaglandin E2 was measurable at 2 h after stimulation with 1 U/ml interleukin 1 alpha, levels increased rapidly up to 6 h and more slowly up to 24 h. Lipopolysaccharide (20 micrograms/ml) induced measurable release of prostaglandin E2 between 2 and 4 h after stimulation and release continued up to 24 h when incubation was terminated.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	69-88
2107866-3	1990	Prostaglandin E2 was measurable at 2 h after stimulation with 1 U/ml interleukin 1 alpha, levels increased rapidly up to 6 h and more slowly up to 24 h. Lipopolysaccharide (20 micrograms/ml) induced measurable release of prostaglandin E2 between 2 and 4 h after stimulation and release continued up to 24 h when incubation was terminated.	Dinoprostone	221-237	interleukin 1 alpha	Homo sapiens	69-88
2105107-3	1990	In contrast, both IL-1 and TNF-alpha modulated vWf release in response to thrombin or phorbol ester.	Phorbol Esters	86-99	interleukin 1 alpha	Homo sapiens	18-22
2297791-6	1990	Staurosporine, a potent inhibitor of PKC in vitro, inhibited Tac expression marginally in YT cells stimulated with FK, and enhanced Tac expression in cultures treated with TPA, TNF alpha, or IL-1.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	191-195
2307483-5	1990	Individual crude decidual extracts inhibited the incorporation of [3H]thymidine into PHA-stimulated lymphocytes, such inhibition being partially reversed by the addition of exogenous recombinant IL-1 to the cultures.	[3h]thymidine	66-79	interleukin 1 alpha	Homo sapiens	195-199
2317653-8	1990	Furthermore, with the addition of indomethacin, IL-1 production in the control subjects and low stage patients improved to the same degree, but it did not reach the control level in the high stage patients.	Indomethacin	34-46	interleukin 1 alpha	Homo sapiens	48-52
2298860-3	1990	In addition, the production of IL-1 appears to be modulated by the gonadal estradiol and progesterone, leading to this study of IL-1 secretion by cultured peripheral monocytes isolated at varying times during the menstrual cycle and pregnancy.	Progesterone	89-101	interleukin 1 alpha	Homo sapiens	31-35
2298860-8	1990	Thus, peripheral monocyte IL-1 secretion appears to be increased by luteal levels of progesterone, although further elevation of progesterone during pregnancy returns IL-1 levels to the preovulatory baseline.	Progesterone	85-97	interleukin 1 alpha	Homo sapiens	26-30
2298860-3	1990	In addition, the production of IL-1 appears to be modulated by the gonadal estradiol and progesterone, leading to this study of IL-1 secretion by cultured peripheral monocytes isolated at varying times during the menstrual cycle and pregnancy.	Estradiol	75-84	interleukin 1 alpha	Homo sapiens	31-35
2298860-8	1990	Thus, peripheral monocyte IL-1 secretion appears to be increased by luteal levels of progesterone, although further elevation of progesterone during pregnancy returns IL-1 levels to the preovulatory baseline.	Progesterone	129-141	interleukin 1 alpha	Homo sapiens	167-171
2298860-10	1990	Thus, IL-1 secretion from cultured monocytes appears to increase with luteal concentrations of progesterone and decrease to preovulatory levels at higher concentrations of the steroid during pregnancy, which may account for the dissociation of high progesterone levels and elevated basal body temperature during late pregnancy.	Progesterone	95-107	interleukin 1 alpha	Homo sapiens	6-10
2298860-10	1990	Thus, IL-1 secretion from cultured monocytes appears to increase with luteal concentrations of progesterone and decrease to preovulatory levels at higher concentrations of the steroid during pregnancy, which may account for the dissociation of high progesterone levels and elevated basal body temperature during late pregnancy.	Steroids	176-183	interleukin 1 alpha	Homo sapiens	6-10
2298860-10	1990	Thus, IL-1 secretion from cultured monocytes appears to increase with luteal concentrations of progesterone and decrease to preovulatory levels at higher concentrations of the steroid during pregnancy, which may account for the dissociation of high progesterone levels and elevated basal body temperature during late pregnancy.	Progesterone	249-261	interleukin 1 alpha	Homo sapiens	6-10
2153178-2	1990	Interaction of IL-1 with its receptor leads to the translocation of protein kinase C (PKC) from the cytosol to the membrane, phosphorylation of the 80-kDa protein that is substrate for PKC, as well as an increase in the level of cAMP.	Cyclic AMP	229-233	interleukin 1 alpha	Homo sapiens	15-19
2153178-5	1990	IL-1 is able to synergize with phorbol esters and is additive with 8-Br cAMP for IL-5 mRNA expression.	Phorbol Esters	31-45	interleukin 1 alpha	Homo sapiens	0-4
2407888-0	1990	Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells.	Reactive Oxygen Species	59-73	interleukin 1 alpha	Homo sapiens	0-19
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	100-119
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	120-130
2407888-4	1990	After a lag period, human recombinant tumor necrosis factor-alpha (TNF-alpha) and human recombinant interleukin 1-alpha IL-1 alpha) both induced significant O2- production measured as SOD inhibitable reduction of cytochrome c, 5 X 10(-5) M, by adherent HMC for up to five hours, the maximum rates being 3.04 +/- 0.08 and 3.2 +/- 0.08 nmol/10(6) HMC/hr for IL-1 alpha and TNF-alpha, respectively.	Oxygen	157-159	interleukin 1 alpha	Homo sapiens	356-366
2407888-6	1990	Catalase inhibitable H2O2 production was also induced by IL-1 alpha and TNF-alpha in a dose dependent manner.	Hydrogen Peroxide	21-25	interleukin 1 alpha	Homo sapiens	57-67
2407888-7	1990	Using scopoletin (40 nM) and 1 microM peroxidase we fluorimetrically measured 1.73 +/- 0.14 and 1.49 +/- 0.19 nmol H2O2/10(6) HMC/hr induced by IL-1 alpha (25 ng/ml) and TNF-alpha (20 ng/ml).	Scopoletin	6-16	interleukin 1 alpha	Homo sapiens	144-154
2297544-2	1990	No stimulation of plasminogen activator activity was seen in response to either preparation of interleukin 1, and in more than half of the cell cultures interleukin 1 caused a significant decrease in the secreted levels of PA activity.	Protactinium	223-225	interleukin 1 alpha	Homo sapiens	153-166
2309101-3	1990	In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-flux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5).	cuprammonium cellulose	103-112	interleukin 1 alpha	Homo sapiens	29-33
2309101-3	1990	In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-flux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5).	cuprammonium cellulose	114-116	interleukin 1 alpha	Homo sapiens	29-33
2309101-3	1990	In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-flux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5).	polyacrylonitrile	129-146	interleukin 1 alpha	Homo sapiens	29-33
2309101-5	1990	To elucidate the mechanism of the activation, aqueous extracts of dialysers containing CU, PS, and AN69 were tested for their ability to induce IL-1 generation in PBMC from healthy donors.	polysulfone P 1700	91-93	interleukin 1 alpha	Homo sapiens	144-148
2309101-6	1990	Extracts from unrinsed CU-containing dialysers caused significant IL-1 synthesis and release, whereas incubation with extracts from dialysers containing PS and AN69 sheet membranes did not.	cuprammonium cellulose	23-25	interleukin 1 alpha	Homo sapiens	66-70
2138997-5	1990	Moreover, both IL-1 beta and IL-1 alpha stimulated prostaglandin E2 production of cultured porcine thyroid cells, although the potency of IL-1 alpha was slightly greater than that of IL-1 beta.	Dinoprostone	51-67	interleukin 1 alpha	Homo sapiens	29-39
2297544-3	1990	Increased levels of prostaglandin E were produced in the same experiments, indicating that the cells were responsive to the interleukin 1 preparations.	Prostaglandins E	20-35	interleukin 1 alpha	Homo sapiens	124-137
1688428-0	1990	Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.	Threonine	184-193	interleukin 1 alpha	Homo sapiens	89-127
2153171-14	1990	Because IL-4 has been reported to inhibit IL-1 production, add-back experiments were performed; addition of IL-1 only partly reconstituted O2-.	Superoxides	139-141	interleukin 1 alpha	Homo sapiens	108-112
2104896-10	1990	Hydrocortisone, at 10 ng/ml, reduced IL-1-induced IL-6 production by more than 50%.	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	37-41
2239430-5	1990	In our experiments we showed that IL-1 at low but not higher doses appears to act intrahypothalamically to stimulate GH and PRL release and to inhibit TSH release.	Thyrotropin	151-154	interleukin 1 alpha	Homo sapiens	34-38
1980972-4	1990	Addition of histamine in concentrations of 10(-7) to 10(-4) M did not suppress, but rather augmented the IL-1 activity release.	Histamine	12-21	interleukin 1 alpha	Homo sapiens	105-109
2406172-7	1990	Using the amnion cells in primary monolayer culture to investigate the regulation of preproendothelin mRNA expression, we found that epidermal growth factor (EGF) and interleukin-1 (IL-1) act to stimulate preproendothelin mRNA levels; in addition, the induction of preproendothelin mRNA by either of these agents is enhanced upon simultaneous treatment with cycloheximide.	Cycloheximide	358-371	interleukin 1 alpha	Homo sapiens	133-186
2327295-0	1990	Modulation of interleukin 1 production by endotoxin, pertussis toxin, and indomethacin.	Indomethacin	74-86	interleukin 1 alpha	Homo sapiens	14-27
2105090-0	1990	Interleukin-1 stimulates prostacyclin production by cultured human endothelial cells by increasing arachidonic acid mobilization and conversion.	Epoprostenol	25-37	interleukin 1 alpha	Homo sapiens	0-13
2305785-5	1990	ODTS can be explained by a nonimmunologic release of interleukin 1 (IL-1) and perhaps other endogenous pyrogens from alveolar macrophages by endotoxin or other ingredients of dusts.	odts	0-4	interleukin 1 alpha	Homo sapiens	53-72
2176076-1	1990	Cultured human periodontal ligament fibroblasts showed synergistic elevations in the synthesis of prostaglandin E and production of cAMP by the administration of parathyroid hormone and cytokines (interleukin 1 alpha, -1 beta, or tumour necrosis factor-alpha).	Prostaglandins E	98-113	interleukin 1 alpha	Homo sapiens	197-258
2176076-1	1990	Cultured human periodontal ligament fibroblasts showed synergistic elevations in the synthesis of prostaglandin E and production of cAMP by the administration of parathyroid hormone and cytokines (interleukin 1 alpha, -1 beta, or tumour necrosis factor-alpha).	Cyclic AMP	132-136	interleukin 1 alpha	Homo sapiens	197-258
2119638-0	1990	The mechanism of action of interleukin-1: a cytokine acting through glycosyl-phosphatidylinositol hydrolysis?	Glycosylphosphatidylinositols	68-97	interleukin 1 alpha	Homo sapiens	27-40
2175579-6	1990	3H-thymidine uptake increased by about 110-376% of control after IL-1 treatment.	Tritium	0-2	interleukin 1 alpha	Homo sapiens	65-69
2175579-6	1990	3H-thymidine uptake increased by about 110-376% of control after IL-1 treatment.	Thymidine	3-12	interleukin 1 alpha	Homo sapiens	65-69
2105090-0	1990	Interleukin-1 stimulates prostacyclin production by cultured human endothelial cells by increasing arachidonic acid mobilization and conversion.	Arachidonic Acid	99-115	interleukin 1 alpha	Homo sapiens	0-13
2105090-1	1990	Interleukin-1 (IL-1) induced slow, lasting activation of human endothelial cells (EC) to release prostacyclin (PGI2).	Epoprostenol	97-109	interleukin 1 alpha	Homo sapiens	0-13
2105090-1	1990	Interleukin-1 (IL-1) induced slow, lasting activation of human endothelial cells (EC) to release prostacyclin (PGI2).	Epoprostenol	97-109	interleukin 1 alpha	Homo sapiens	15-19
2105090-1	1990	Interleukin-1 (IL-1) induced slow, lasting activation of human endothelial cells (EC) to release prostacyclin (PGI2).	Epoprostenol	111-115	interleukin 1 alpha	Homo sapiens	0-13
2105090-1	1990	Interleukin-1 (IL-1) induced slow, lasting activation of human endothelial cells (EC) to release prostacyclin (PGI2).	Epoprostenol	111-115	interleukin 1 alpha	Homo sapiens	15-19
2105090-3	1990	The continuous presence of IL-1 was not required, but about a 1-hour stimulation with the cytokine was sufficient to trigger the cells to synthesize PGI2 for several hours.	Epoprostenol	149-153	interleukin 1 alpha	Homo sapiens	27-31
2105090-4	1990	The spectrum of 3H-AA conversion shows that, in addition to 6-keto-prostaglandin F1 alpha, prostaglandin F2 alpha also was raised after IL-1.	Dinoprost	91-107	interleukin 1 alpha	Homo sapiens	136-140
2105090-5	1990	The recovery of PGI2 synthesis after aspirin was faster in IL-1-treated EC than in control cells.	Epoprostenol	16-20	interleukin 1 alpha	Homo sapiens	59-63
2105090-5	1990	The recovery of PGI2 synthesis after aspirin was faster in IL-1-treated EC than in control cells.	Aspirin	37-44	interleukin 1 alpha	Homo sapiens	59-63
2105090-6	1990	These data define some of the characteristics of IL-1 stimulation of PGI2 and suggest that this process is mediated both by endogenous AA mobilization and by an increase in cyclooxygenase activity.	Epoprostenol	69-73	interleukin 1 alpha	Homo sapiens	49-53
2293911-8	1990	Our data demonstrate that IL-1 enhances TC adhesion to the vascular surface both in vitro and in vivo, suggesting that IL-1 can facilitate the metastatic process.	Technetium	40-42	interleukin 1 alpha	Homo sapiens	26-30
2085666-0	1990	Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells.	Dexamethasone	10-23	interleukin 1 alpha	Homo sapiens	27-31
2261511-2	1990	Pentoxifylline has been shown to prevent PMN activation by endotoxin and cytokines such as TNF alpha and IL-1.	Pentoxifylline	0-14	interleukin 1 alpha	Homo sapiens	105-109
2085666-1	1990	The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied.	Dexamethasone	14-27	interleukin 1 alpha	Homo sapiens	55-59
2293911-8	1990	Our data demonstrate that IL-1 enhances TC adhesion to the vascular surface both in vitro and in vivo, suggesting that IL-1 can facilitate the metastatic process.	Technetium	40-42	interleukin 1 alpha	Homo sapiens	119-123
1966546-1	1990	Tumor necrosis factor (TNF) and interleukin-1 (IL-1) enhanced the phosphorylation of identical cytosolic 65 kDa protein (P65 or l-plastin) and 74 kDa protein (P74) at serine residues in human peripheral blood mononuclear cells (PBMC).	Serine	167-173	interleukin 1 alpha	Homo sapiens	0-51
2128766-4	1990	The present in vitro studies show that IL-1 and TNF-alpha, but not IFN-gamma significantly lower the pO2-dependent formation of EPO in HepG2 cultures.	PO-2	101-104	interleukin 1 alpha	Homo sapiens	39-43
2151761-6	1990	Iodine 125-IL1 was crosslinked to the two receptor forms and a partial peptide map analysis of the two receptor/ligand complexes was performed.	Iodine	0-6	interleukin 1 alpha	Homo sapiens	11-14
2146129-2	1990	This inhibition is potentiated by agents which block IL-1-stimulated PGE2 production (J. Clin.	Dinoprostone	69-73	interleukin 1 alpha	Homo sapiens	53-57
2104586-9	1990	Since the effect of TNF and IL-1 on renin can be blocked by a (CO) inhibitor, the studies indicate a role of prostaglandins in their action.	Prostaglandins	109-123	interleukin 1 alpha	Homo sapiens	28-32
2146129-5	1990	In contrast, expression of types I and III collagens and fibronectin, matrix components produced by chondrocytes that have lost cartilage-specific phenotype, is increased by IL-1, particularly when IL-1-stimulated synthesis of PGE2 is blocked by a prostaglandin synthetase inhibitor.	Dinoprostone	227-231	interleukin 1 alpha	Homo sapiens	174-178
2146129-5	1990	In contrast, expression of types I and III collagens and fibronectin, matrix components produced by chondrocytes that have lost cartilage-specific phenotype, is increased by IL-1, particularly when IL-1-stimulated synthesis of PGE2 is blocked by a prostaglandin synthetase inhibitor.	Dinoprostone	227-231	interleukin 1 alpha	Homo sapiens	198-202
2146129-8	1990	The present studies were undertaken to compare the effects of etodolac and other nonsteroidal anti-inflammatory drugs (NSAIDs) on IL-1-induced modulation of chondrocyte phenotype.	Etodolac	62-70	interleukin 1 alpha	Homo sapiens	130-134
2146129-11	1990	Indomethacin (0.3-300 nM) or ketoprofen (2-2000 nM) produced a dose-dependent suppression of type II collagen synthesis associated with decreased levels of type II collagen mRNA in the absence of IL-1, while they potentiated the inhibitory effects of IL-1.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	251-255
2146129-11	1990	Indomethacin (0.3-300 nM) or ketoprofen (2-2000 nM) produced a dose-dependent suppression of type II collagen synthesis associated with decreased levels of type II collagen mRNA in the absence of IL-1, while they potentiated the inhibitory effects of IL-1.	Ketoprofen	29-39	interleukin 1 alpha	Homo sapiens	196-200
2146129-11	1990	Indomethacin (0.3-300 nM) or ketoprofen (2-2000 nM) produced a dose-dependent suppression of type II collagen synthesis associated with decreased levels of type II collagen mRNA in the absence of IL-1, while they potentiated the inhibitory effects of IL-1.	Ketoprofen	29-39	interleukin 1 alpha	Homo sapiens	251-255
2146129-13	1990	Etodolac unmasked a stimulatory effect of IL-1 on synthesis of type I collagen and fibronectin and levels of type I collagen mRNA, but to a lesser extent than indomethacin.	Etodolac	0-8	interleukin 1 alpha	Homo sapiens	42-46
2226666-6	1990	In a third study, IL-1 from untreated postmenopausal women was found to be higher than in either untreated premenopausal or estrogen/progesterone-treated postmenopausal women.	Progesterone	133-145	interleukin 1 alpha	Homo sapiens	18-22
2405873-5	1990	This overview of the biology of IL-1 on the tenth anniversary of its turbulent life has been compiled by Franco di Giovine and Gordon Duff.	giovine	115-122	interleukin 1 alpha	Homo sapiens	32-36
2226666-12	1990	This data indicates that monocyte IL-1 production mirrors the rate of bone turnover in both the healthy and osteoporotic patient, and that alteration in IL-1 production may underlie the postmenopausal acceleration of bone loss and its inhibition by ovarian steroids.	Steroids	257-265	interleukin 1 alpha	Homo sapiens	153-157
2182739-3	1990	In particular, we show data concerning: 1) the use of interleukin 3, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 1 to expand hematopoietic progenitor cell growth in the early phase of ABMT; 2) in vitro marrow purging with Mafosfamide and GM-CSF in chronic myelogenous leukemia; and 3) growth requirements of MY10-derived leukemic colony-forming units.	mafosfamide	252-263	interleukin 1 alpha	Homo sapiens	131-144
2083970-7	1990	Interleukin-1 also inhibited MStF responses and potentiated MIF responses to Con A stimulation by human mononuclear cells whereas interleukin-2 did not influence these responses.	mstf	29-33	interleukin 1 alpha	Homo sapiens	0-13
1689279-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)-stimulated human monocytes, interleukin 1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	quinoline	135-144	interleukin 1 alpha	Homo sapiens	89-108
1689279-1	1990	Previous studies have shown that in lipopolysaccharide (LPS)-stimulated human monocytes, interleukin 1 (IL-1) production is altered by quinoline derivative antibiotics (quinolones), in a way which depends both on the dose and on the agents used.	Quinolones	169-179	interleukin 1 alpha	Homo sapiens	89-108
2184136-0	1990	Production of interleukin 1 from human monocytes stimulated by synthetic lipid A subunit analogues.	Lipid A	73-80	interleukin 1 alpha	Homo sapiens	14-27
2303321-0	1990	3-Deazaadenosine--an inhibitor of interleukin 1 production by human peripheral blood monocytes.	3-deazaadenosine	0-16	interleukin 1 alpha	Homo sapiens	34-47
2184136-1	1990	We have investigated that synthetic lipid A subunit analogues (GLA compounds) as well as E. coli type lipopolysaccharide (LPS) and synthetic lipid A (compound 506) are able to stimulate human monocytes to release IL-1 in vitro.	Lipid A	36-43	interleukin 1 alpha	Homo sapiens	213-217
2303321-4	1990	c3Ado also had direct effects on IL-1 biological activity in two separate assays; thymocyte proliferation and induction of prostaglandin release.	prostaglandin release	123-144	interleukin 1 alpha	Homo sapiens	33-37
2184136-1	1990	We have investigated that synthetic lipid A subunit analogues (GLA compounds) as well as E. coli type lipopolysaccharide (LPS) and synthetic lipid A (compound 506) are able to stimulate human monocytes to release IL-1 in vitro.	gamma-Linolenic Acid	63-66	interleukin 1 alpha	Homo sapiens	213-217
2184136-1	1990	We have investigated that synthetic lipid A subunit analogues (GLA compounds) as well as E. coli type lipopolysaccharide (LPS) and synthetic lipid A (compound 506) are able to stimulate human monocytes to release IL-1 in vitro.	Lipid A	141-148	interleukin 1 alpha	Homo sapiens	213-217
2184136-2	1990	Of monosaccharide-type GLA compounds, GLA-60 was found to be more active for the induction of IL-1 production than GLA-59 and GLA-27, and similar to that of LPS or compound 506.	gamma-Linolenic Acid	23-26	interleukin 1 alpha	Homo sapiens	94-98
2184136-2	1990	Of monosaccharide-type GLA compounds, GLA-60 was found to be more active for the induction of IL-1 production than GLA-59 and GLA-27, and similar to that of LPS or compound 506.	gamma-Linolenic Acid	38-41	interleukin 1 alpha	Homo sapiens	94-98
2184136-2	1990	Of monosaccharide-type GLA compounds, GLA-60 was found to be more active for the induction of IL-1 production than GLA-59 and GLA-27, and similar to that of LPS or compound 506.	gamma-Linolenic Acid	38-41	interleukin 1 alpha	Homo sapiens	94-98
2184136-2	1990	Of monosaccharide-type GLA compounds, GLA-60 was found to be more active for the induction of IL-1 production than GLA-59 and GLA-27, and similar to that of LPS or compound 506.	gamma-Linolenic Acid	38-41	interleukin 1 alpha	Homo sapiens	94-98
2384297-4	1990	In other long-term culture experiments, IL-1a was shown to enhance fibroblast-induced GAG loss from cartilage.	Glycosaminoglycans	86-89	interleukin 1 alpha	Homo sapiens	40-45
2184136-3	1990	GLA-60 could induce not only the secretion of IL-1 into culture supernatant but also the expression of membrane-associated form of IL-1 in human monocytes.	gamma-Linolenic Acid	0-3	interleukin 1 alpha	Homo sapiens	46-50
2184136-3	1990	GLA-60 could induce not only the secretion of IL-1 into culture supernatant but also the expression of membrane-associated form of IL-1 in human monocytes.	gamma-Linolenic Acid	0-3	interleukin 1 alpha	Homo sapiens	131-135
2184136-5	1990	These results show that synthetic lipid A analogues of low toxicity, in particular GLA-60, are active in inducing IL-1 production in human monocytes.	gamma-Linolenic Acid	83-86	interleukin 1 alpha	Homo sapiens	114-118
2104887-7	1990	The calcium ionophores A23187 and ionomycin were found to dramatically enhance the release and processing of murine and human IL-1.	Calcium	4-11	interleukin 1 alpha	Homo sapiens	126-130
2104887-7	1990	The calcium ionophores A23187 and ionomycin were found to dramatically enhance the release and processing of murine and human IL-1.	Calcimycin	23-29	interleukin 1 alpha	Homo sapiens	126-130
2104887-7	1990	The calcium ionophores A23187 and ionomycin were found to dramatically enhance the release and processing of murine and human IL-1.	Ionomycin	34-43	interleukin 1 alpha	Homo sapiens	126-130
2295789-0	1990	Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes.	paraform	61-77	interleukin 1 alpha	Homo sapiens	13-23
2113649-7	1990	In contrast, macrophages from silicone- and PVC-loaded animals spontaneously released high levels of IL 1 (median 21.8; range 10-36.7) and 94 (range 36-336) U per 10(6) cells respectively).	Silicones	30-38	interleukin 1 alpha	Homo sapiens	101-105
2295836-0	1990	Keratinocyte prostaglandin synthesis is enhanced by IL-1.	Prostaglandins	13-26	interleukin 1 alpha	Homo sapiens	52-56
2295836-1	1990	Keratinocytes are a rich source of IL-1, a cytokine which stimulates prostaglandin synthesis in many cell types.	Prostaglandins	69-82	interleukin 1 alpha	Homo sapiens	35-39
2295836-3	1990	Exogenous IL-1 increased basal cellular prostaglandin synthesis (particularly PGE2) threefold.	Prostaglandins	40-53	interleukin 1 alpha	Homo sapiens	10-14
2295836-3	1990	Exogenous IL-1 increased basal cellular prostaglandin synthesis (particularly PGE2) threefold.	Dinoprostone	78-82	interleukin 1 alpha	Homo sapiens	10-14
2295836-4	1990	Increased PGE2 synthesis in response to IL-1 was inhibited by cycloheximide, suggesting a requirement for new protein synthesis.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	40-44
2295836-4	1990	Increased PGE2 synthesis in response to IL-1 was inhibited by cycloheximide, suggesting a requirement for new protein synthesis.	Cycloheximide	62-75	interleukin 1 alpha	Homo sapiens	40-44
2295836-6	1990	The amount of IL-1 released was sufficient to increase PGE2 synthesis when exogenously added to unstimulated cells, suggesting a causal relationship.	Dinoprostone	55-59	interleukin 1 alpha	Homo sapiens	14-18
2295836-9	1990	These data suggest that keratinocyte IL-1 may be partially responsible for induction of keratinocyte PGE2 synthesis after UVB irradiation.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	37-41
2255000-4	1990	The response of thymocytes treated with nylon wool to exogenous IL-1 was significantly suppressed in the presence of TDSF, suggesting that TDSF can inhibit the action of IL-1.	nylon wool	40-50	interleukin 1 alpha	Homo sapiens	64-68
2255000-4	1990	The response of thymocytes treated with nylon wool to exogenous IL-1 was significantly suppressed in the presence of TDSF, suggesting that TDSF can inhibit the action of IL-1.	nylon wool	40-50	interleukin 1 alpha	Homo sapiens	170-174
1983705-7	1990	The FTAF activity was inhibited about 50% by recombinant human interleukin-1 (IL-1) beta antiserum but not by recombinant human IL-1 alpha antiserum.	ftaf	4-8	interleukin 1 alpha	Homo sapiens	63-76
2113649-8	1990	Following in vitro stimulation with bacterial lipopolysaccharide (LPS), peritoneal macrophages from silicone- and PVC-treated animals released large amounts of IL 1 (median 538 (range 359-2017) U and median 653 (range 326-1134) U per 10(6) cells, respectively) as compared to LPS-stimulated macrophages from control animals (median 332 (range 130-306) U per 10(6) cells].	Silicones	100-108	interleukin 1 alpha	Homo sapiens	160-164
2113649-9	1990	Zymosan or LPS stimulation of splenic cells from silicone- and PVC-loaded animals also secreted increased quantities of IL 1 as compared to controls.	Zymosan	0-7	interleukin 1 alpha	Homo sapiens	120-124
2113649-9	1990	Zymosan or LPS stimulation of splenic cells from silicone- and PVC-loaded animals also secreted increased quantities of IL 1 as compared to controls.	Silicones	49-57	interleukin 1 alpha	Homo sapiens	120-124
33236262-5	2021	Results demonstrated that ISACN negatively modulated the production of inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 by cultured macrophages.	isacn	26-31	interleukin 1 alpha	Homo sapiens	94-102
2308778-3	1990	Such mechanisms are often the consequences of the induction by IL-1 of lipid mediators (e.g. prostaglandins, platelet activating factor, etc).	Prostaglandins	93-107	interleukin 1 alpha	Homo sapiens	63-67
2204930-5	1990	Selected chemical antagonists of the arachidonic acid cascade have been shown to inhibit IL-1 production.	Arachidonic Acid	37-53	interleukin 1 alpha	Homo sapiens	89-93
2205864-1	1990	To date, the notion that the AU rich motif in the 3" UT of GM-CSF mRNA can function as an IL-1 response element has not been adequately examined.	Gold	29-31	interleukin 1 alpha	Homo sapiens	90-94
2150570-2	1990	This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1).	Dinoprostone	119-135	interleukin 1 alpha	Homo sapiens	154-173
2150570-2	1990	This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1).	Dinoprostone	137-141	interleukin 1 alpha	Homo sapiens	154-173
2150570-6	1990	Etodolac preserved collagen phenotype in human chondrocytes cultured in a monolayer in the presence of IL-1.	Etodolac	0-8	interleukin 1 alpha	Homo sapiens	103-107
33774155-8	2021	As anti-inflammatory functions of AAT are of increasing clinical interest, we compared the potential of two widely used AAT preparations, Prolastin  and Respreeza , to inhibit the ATP-induced release of IL-1beta using human monocytic U937 cells.	Adenosine Triphosphate	180-183	interleukin 1 alpha	Homo sapiens	203-211
33779948-5	2021	RESULTS: PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-alpha and IL-1betain THP-1 cells.	peoniflorin	9-11	interleukin 1 alpha	Homo sapiens	148-152
33774155-10	2021	The AAT preparation Respreeza  is less active compared to Prolastin  regarding the inhibition of the ATP-induced release of monocytic IL-1beta.	Adenosine Triphosphate	101-104	interleukin 1 alpha	Homo sapiens	134-142
33945102-9	2021	Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1.	Imipramine	0-10	interleukin 1 alpha	Homo sapiens	67-75
33813027-10	2021	In addition, PA compounds downregulated the expression of VCAM-1, VE-cadherin, VEGFa, VEGFR2, TGF-beta, and IL-1beta, in inflamed ECs.	Protactinium	13-15	interleukin 1 alpha	Homo sapiens	108-116
33945102-9	2021	Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1.	Desipramine	12-23	interleukin 1 alpha	Homo sapiens	67-75
33945102-9	2021	Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1.	Fluoxetine	29-39	interleukin 1 alpha	Homo sapiens	67-75
33767763-0	2021	Quercetin suppresses apoptosis of chondrocytes induced by IL-1beta via inactivation of p38 MAPK signaling pathway.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	58-66
33767774-12	2021	In addition, the TNF-alpha-induced increase in the cell proliferative and migratory rates and the production of IL-6 and IL-1beta were markedly inhibited following miR-23a-5p overexpression.	mir-23a-5p	164-174	interleukin 1 alpha	Homo sapiens	121-129
33777193-7	2021	Furthermore, miR-23 overexpression suppressed inflammation via reducing TNF-alpha, IL-1beta and IL-8 expression levels compared with the NC mimic group.	mir-23	13-19	interleukin 1 alpha	Homo sapiens	83-91
33822828-4	2021	Age-stratified analyses of uninfected, asymptomatic Malian individuals before the malaria season revealed that monocytes of adults produced lower levels of inflammatory cytokines (IL-1beta, IL-6 and TNF) in response to Pf-iRBC stimulation compared to monocytes of Malian children and malaria-naive U.S. adults.	pf-irbc	219-226	interleukin 1 alpha	Homo sapiens	180-188
33822828-5	2021	Moreover, monocytes of Malian children produced lower levels of IL-1beta and IL-6 following Pf-iRBC stimulation compared to 4-6-month-old infants.	pf-irbc	92-99	interleukin 1 alpha	Homo sapiens	64-72
33769089-5	2021	Fasudil (10-5-10-7 M) reversed all these changes induced by IL-1beta.	fasudil	0-7	interleukin 1 alpha	Homo sapiens	60-68
33813772-0	2021	The efficacy of interleukin-1 antagonist drugs in combination with colchicine in patients with FMF-AA with colchicine-resistance after kidney transplantation: A study with histopathologic evidence.	Colchicine	107-117	interleukin 1 alpha	Homo sapiens	16-29
33813772-1	2021	BACKGROUND: The efficacy of anti-interleukin-1 (IL-1) drugs in kidney transplant patients with FMF-AA who developed colchicine-resistance has not been clearly demonstrated.	Colchicine	116-126	interleukin 1 alpha	Homo sapiens	33-46
33793375-2	2021	As mesalazine (5-ASA) could be involved in ER stress, proinflammatory and ER stress-associated cytokines and markers were measured.Results: Mesalazine (5-ASA) suppressed IL-6 mRNA in healthy donors and in HLA-B27+ and HLA-B27- patients but did not lead to induction and secretion of IL-1beta.	Mesalamine	140-150	interleukin 1 alpha	Homo sapiens	283-291
33793375-2	2021	As mesalazine (5-ASA) could be involved in ER stress, proinflammatory and ER stress-associated cytokines and markers were measured.Results: Mesalazine (5-ASA) suppressed IL-6 mRNA in healthy donors and in HLA-B27+ and HLA-B27- patients but did not lead to induction and secretion of IL-1beta.	Mesalamine	152-157	interleukin 1 alpha	Homo sapiens	283-291
33798839-7	2021	Metformin exposure was also associated with decreased levels of the inflammatory cytokines TNFalpha, IL-1a, IL-1b and IL-6 in serum, placenta and omental tissue taken from pregnant women.	Metformin	0-9	interleukin 1 alpha	Homo sapiens	101-106
33786645-9	2021	4-PBA pretreatment remarkably reduced cell-crystal adhesion and the secretions of IL-1beta and LDH, whereas the results of TM pretreatment were the opposite.	4-phenylbutyric acid	0-5	interleukin 1 alpha	Homo sapiens	82-90
33805302-4	2021	Using matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI), coupled with biochemical analyses and behavioral tests, we demonstrate that icaritin improves PD by attenuating the the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activity and stabilizing mitochondrial function, based on our extensive analyses showing the inhibition of NLRP3 inflammasome, reduction of NLRP3-mediated IL-1beta secretion, and improvements in the levels of antioxidant molecules.	icaritin	165-173	interleukin 1 alpha	Homo sapiens	444-452
33818552-10	2021	Chrysin increased antioxidant activity and reduced markers of oxidative stress (SOD and MDA) and inflammation (MPO and IL-1beta), all of which were blocked by ZnPP.	zinc protoporphyrin	159-163	interleukin 1 alpha	Homo sapiens	119-127
33764560-4	2022	RESULTS: Decidualized cells treated with BCM from impaired developed blastocysts increased IL-1beta production.	bcm	41-44	interleukin 1 alpha	Homo sapiens	91-99
33779714-8	2021	At the same time, fasudil led to the reduction of IL-1beta, TNF-alpha, IL-6 and IL-8 mRNA levels in insulin-treated cells.	fasudil	18-25	interleukin 1 alpha	Homo sapiens	50-58
33774704-10	2021	Compared with healthy controls, clozapine-treated patients" BMI, blood glucose, and proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) increased significantly.	Clozapine	32-41	interleukin 1 alpha	Homo sapiens	111-119
33774704-11	2021	In clozapine-treated patients, a higher clozapine daily dosage was associated with higher levels of the proinflammatory cytokines IL-1beta and IL-6, and a significant positive correlation was observed between blood glucose levels and the proinflammatory cytokines IL-6 and TNF-alpha.	Clozapine	40-49	interleukin 1 alpha	Homo sapiens	130-138
33760701-4	2021	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18 while the molecular mechanism by which tetracycline inhibits inflammasome-caspase-1 signaling remains unknown.	Tetracycline	29-41	interleukin 1 alpha	Homo sapiens	97-105
33809417-10	2021	Low-dose garcinol did not affect cardiomyocyte viability but significantly reduced mitochondrial ROS, CRP, IL-1beta, IL-6, and TNF-alpha production in Lp(a)-stimulated cardiomyocytes (p < 0.05).	garcinol	9-17	interleukin 1 alpha	Homo sapiens	107-115
33760701-10	2021	In experimental ALI, tetracycline significantly diminished lung injury and pulmonary inflammation by selectively inhibiting caspase-1-dependent IL-1beta and IL-18 production leading to improved survival.	Tetracycline	21-33	interleukin 1 alpha	Homo sapiens	144-152
33760701-11	2021	Tetracycline also reduced the production of IL-1beta and IL-18 by alveolar leucocytes from patients with direct ARDS.	Tetracycline	0-12	interleukin 1 alpha	Homo sapiens	44-52
33771440-6	2021	RESULTS: Both conventional hydrogels (etafilcon A, omafilcon A) and two of the four silicone hydrogels tested (balafilcon A, comfilcon A), exhibited some uptake of IL-1beta, IL-8 or TNF-alpha (p < 0.05).	omafilcon a	51-62	interleukin 1 alpha	Homo sapiens	164-172
33771440-6	2021	RESULTS: Both conventional hydrogels (etafilcon A, omafilcon A) and two of the four silicone hydrogels tested (balafilcon A, comfilcon A), exhibited some uptake of IL-1beta, IL-8 or TNF-alpha (p < 0.05).	Silicones	84-92	interleukin 1 alpha	Homo sapiens	164-172
33771440-6	2021	RESULTS: Both conventional hydrogels (etafilcon A, omafilcon A) and two of the four silicone hydrogels tested (balafilcon A, comfilcon A), exhibited some uptake of IL-1beta, IL-8 or TNF-alpha (p < 0.05).	balafilcon A	111-123	interleukin 1 alpha	Homo sapiens	164-172
33771440-6	2021	RESULTS: Both conventional hydrogels (etafilcon A, omafilcon A) and two of the four silicone hydrogels tested (balafilcon A, comfilcon A), exhibited some uptake of IL-1beta, IL-8 or TNF-alpha (p < 0.05).	comfilcon A	125-136	interleukin 1 alpha	Homo sapiens	164-172
33767939-3	2021	The aim of this study was to investigate the therapeutic effects of the combination of erythropoietin and methylprednisolone in the treatment of ischemia-reperfusion injury to the spinal cord and to analyze its effects on the levels of interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-1RA), and interleukin-8 (IL-8).	Methylprednisolone	106-124	interleukin 1 alpha	Homo sapiens	256-264
33799992-5	2021	RESULTS: Several effects of clodronate have been observed in animal models of OA, including depletion of synovial lining cells that results in reduced production of chemokines (IL-1, TNF- alpha), growth factors (TGF-beta, BMP 2/4), and metalloproteases (MMP 2/3/9); prevention of cartilage damage, synovial hyperplasia, and proteoglycans loss; reduction in joint inflammation, joint swelling, and osteophyte formation.	Clodronic Acid	28-38	interleukin 1 alpha	Homo sapiens	177-181
33778274-8	2021	Results: First, the reduced mitochondrial membrane potential (DeltaPsim) and secretion of proinflammatory factors (IL-1beta, IL-8, and MCP-1) induced by TNF-alpha were significantly reversed by treatment with Feprazone.	Feprazone	209-218	interleukin 1 alpha	Homo sapiens	115-123
33776573-0	2021	miR-708 Negatively Regulates TNFalpha/IL-1beta Signaling by Suppressing NF-kappaB and Arachidonic Acid Pathways.	Arachidonic Acid	86-102	interleukin 1 alpha	Homo sapiens	38-46
33776573-3	2021	More specifically, TNFalpha/IL-1beta promotes expression of the prostaglandin E2- (PGE2-) producing enzymes, cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1).	Dinoprostone	64-80	interleukin 1 alpha	Homo sapiens	28-36
33776573-3	2021	More specifically, TNFalpha/IL-1beta promotes expression of the prostaglandin E2- (PGE2-) producing enzymes, cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1).	Dinoprostone	83-87	interleukin 1 alpha	Homo sapiens	28-36
33776573-12	2021	Transient transfection of miR-708 suppressed TNFalpha/IL-1beta-induced changes in COX-2, mPGES-1, and PGE2 levels.	Dinoprostone	102-106	interleukin 1 alpha	Homo sapiens	54-62
33802355-9	2021	gamma-linolenic acid, brinzolamide, and INCA-6 significantly reduced IL-1beta induced luciferase activity and potentiated the anti-inflammatory effect of dexamethasone in A549/NF-kappaB-luc reporter cells.	brinzolamide	22-34	interleukin 1 alpha	Homo sapiens	69-77
33802355-9	2021	gamma-linolenic acid, brinzolamide, and INCA-6 significantly reduced IL-1beta induced luciferase activity and potentiated the anti-inflammatory effect of dexamethasone in A549/NF-kappaB-luc reporter cells.	INCA-6	40-46	interleukin 1 alpha	Homo sapiens	69-77
33802355-5	2021	The top five drug compound candidates underwent in vitro validation in NF-kappaB-based luciferase reporter A549 cells stimulated by IL-1beta +- dexamethasone.	Dexamethasone	144-157	interleukin 1 alpha	Homo sapiens	132-140
33802355-9	2021	gamma-linolenic acid, brinzolamide, and INCA-6 significantly reduced IL-1beta induced luciferase activity and potentiated the anti-inflammatory effect of dexamethasone in A549/NF-kappaB-luc reporter cells.	gamma-Linolenic Acid	0-20	interleukin 1 alpha	Homo sapiens	69-77
33590831-8	2021	Collectively, miR-33b-3p significantly alleviated IL-1beta-induced inflammation and apoptosis by downregulating IRAK3, which may serve as a promising target for OA.	mir-33b-3p	14-24	interleukin 1 alpha	Homo sapiens	50-58
33804447-0	2021	Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1beta-Induced Mitochondrial Dysfunction in Human Chondrocytes.	Nitric Oxide	24-36	interleukin 1 alpha	Homo sapiens	55-63
33804447-1	2021	Interleukin (IL)-1beta is an important pro-inflammatory cytokine in the progression of osteoarthritis (OA), which impairs mitochondrial function and induces the production of nitric oxide (NO) in chondrocytes.	Nitric Oxide	175-187	interleukin 1 alpha	Homo sapiens	0-22
33804447-8	2021	Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment.	Cyclic AMP	15-19	interleukin 1 alpha	Homo sapiens	41-49
33804447-8	2021	Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment.	Cyclic AMP	15-19	interleukin 1 alpha	Homo sapiens	83-91
33804447-8	2021	Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment.	Colforsin	23-32	interleukin 1 alpha	Homo sapiens	41-49
33804447-8	2021	Enhancement of cAMP by forskolin reduced IL-1beta-induced NO release and prevented IL-1beta-induced mitochondrial impairment.	Colforsin	23-32	interleukin 1 alpha	Homo sapiens	83-91
33804447-11	2021	Increased intracellular cAMP or inhibition of AMPK prevented both IL-1beta-induced NO release and mitochondrial dysfunction.	Cyclic AMP	24-28	interleukin 1 alpha	Homo sapiens	66-74
33590831-3	2021	Here, we first found that IRAK3 was upregulated, while miR-33b-3p was downregulated in the cartilage of OA patients and IL-1beta-induced CHON-001 cells.	mir-33b-3p	55-65	interleukin 1 alpha	Homo sapiens	120-128
33590831-7	2021	Importantly, IRAK3 knockdown imitated, while overexpression reversed the effects of miR-33b-3p on IL-1beta-induced inflammation and apoptosis in CHON-001 cells.	mir-33b-3p	84-94	interleukin 1 alpha	Homo sapiens	98-106
33236146-11	2021	The protein expression levels of AKT, phosphorylated (p)-AKT, mTOR and p-mTOR in the PI3K/AKT/mTOR signaling pathway were decreased in the IL-1beta-induced SW1353 cells following scutellarin treatment.	scutellarin	179-190	interleukin 1 alpha	Homo sapiens	139-147
33146542-6	2021	Exposing hPACs and PAC 266-6 to pro-inflammatory cytokines (hyper IL-6, TNF-alpha, and IL-1beta) was found to lead to a significant inhibition in thiamin uptake.	hpacs	9-14	interleukin 1 alpha	Homo sapiens	87-95
33146542-6	2021	Exposing hPACs and PAC 266-6 to pro-inflammatory cytokines (hyper IL-6, TNF-alpha, and IL-1beta) was found to lead to a significant inhibition in thiamin uptake.	Thiamine	146-153	interleukin 1 alpha	Homo sapiens	87-95
33236146-10	2021	The IL-1beta-induced increase in the expression of IL-6 was decreased by treatment with scutellarin; however, scutellarin did not alter the expression of C-reactive protein and tumor necrosis factor-alpha.	scutellarin	88-99	interleukin 1 alpha	Homo sapiens	4-12
31412862-6	2019	BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Berberine	0-3	interleukin 1 alpha	Homo sapiens	82-100
33379200-7	2020	Iron oxide increased IL-8 production while silica also induced significant production of IL-1beta.	Silicon Dioxide	43-49	interleukin 1 alpha	Homo sapiens	89-97
33379200-8	2020	Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs.	ferric oxide	5-15	interleukin 1 alpha	Homo sapiens	73-81
33379200-8	2020	Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs.	Silicon Dioxide	20-26	interleukin 1 alpha	Homo sapiens	73-81
33237143-8	2020	In addition, vinpocetine decreased the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta.	vinpocetine	13-24	interleukin 1 alpha	Homo sapiens	152-160
33233960-12	2020	MiR-219-5p was negatively correlated with, while TLR4 was positively correlated with the levels of IL-1beta and TNF-alpha.	mir-219-5p	0-10	interleukin 1 alpha	Homo sapiens	99-107
31412862-6	2019	BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Berberine	0-3	interleukin 1 alpha	Homo sapiens	102-111
31412862-6	2019	BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Berberine	0-3	interleukin 1 alpha	Homo sapiens	133-141
25589619-6	2015	Dabrafenib and trametinib in BRAF V600E/K, and trametinib in BRAF wild-type tumor cells induced apoptosis markers, upregulated HLA molecule expression, and downregulated certain immunosuppressive factors such as PD-L1, IL1, IL8, NT5E, and VEGFA.	trametinib	47-57	interleukin 1 alpha	Homo sapiens	219-222
24648681-1	2014	BACKGROUND: Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.	Lipid Peroxides	12-26	interleukin 1 alpha	Homo sapiens	123-141
25589619-6	2015	Dabrafenib and trametinib in BRAF V600E/K, and trametinib in BRAF wild-type tumor cells induced apoptosis markers, upregulated HLA molecule expression, and downregulated certain immunosuppressive factors such as PD-L1, IL1, IL8, NT5E, and VEGFA.	dabrafenib	0-10	interleukin 1 alpha	Homo sapiens	219-222
24648681-1	2014	BACKGROUND: Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.	Lipid Peroxides	12-26	interleukin 1 alpha	Homo sapiens	143-152
24648681-1	2014	BACKGROUND: Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.	Lipid Peroxides	28-31	interleukin 1 alpha	Homo sapiens	123-141
24648681-1	2014	BACKGROUND: Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.	Lipid Peroxides	28-31	interleukin 1 alpha	Homo sapiens	143-152
18722610-7	2009	The IL-1alpha-stimulated MMP9 mRNA production was suppressed by cortisol but not P. Cortisol but not P also dose-dependently suppressed IL-1alpha-stimulated MMP9 gelatinase activity and this effect was blocked by the glucocorticoid receptor antagonist RU486.	Mifepristone	252-257	interleukin 1 alpha	Homo sapiens	4-13
18722610-7	2009	The IL-1alpha-stimulated MMP9 mRNA production was suppressed by cortisol but not P. Cortisol but not P also dose-dependently suppressed IL-1alpha-stimulated MMP9 gelatinase activity and this effect was blocked by the glucocorticoid receptor antagonist RU486.	Mifepristone	252-257	interleukin 1 alpha	Homo sapiens	136-145
18722610-9	2009	Because IL-1alpha also generates cortisol formation in OSE by stimulating cortisone reductase activity, these results support a role for intracrine cortisol in minimizing proteolytic damage to the OSE at ovulation.	Hydrocortisone	33-41	interleukin 1 alpha	Homo sapiens	8-17
18722610-9	2009	Because IL-1alpha also generates cortisol formation in OSE by stimulating cortisone reductase activity, these results support a role for intracrine cortisol in minimizing proteolytic damage to the OSE at ovulation.	serine O-sulfate	55-58	interleukin 1 alpha	Homo sapiens	8-17
15888106-7	2005	Exogenous PGE2 significantly suppressed IL-1alpha-induced IL-6 production.	Dinoprostone	10-14	interleukin 1 alpha	Homo sapiens	40-49
15888106-8	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced IL-6 production, although 17-phenyl-omega-trinor PGE2, an EP1 agonist, and ONO-AP-324, an EP3 agonist, did not affect it.	butaprost	0-9	interleukin 1 alpha	Homo sapiens	102-111
15888106-6	2005	RESULTS: Indomethacin significantly enhanced IL-1alpha-induced IL-6 production by PDL cells, although it completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	9-21	interleukin 1 alpha	Homo sapiens	45-54
15888106-6	2005	RESULTS: Indomethacin significantly enhanced IL-1alpha-induced IL-6 production by PDL cells, although it completely inhibited IL-1alpha-induced PGE2 production.	Indomethacin	9-21	interleukin 1 alpha	Homo sapiens	126-135
15888106-6	2005	RESULTS: Indomethacin significantly enhanced IL-1alpha-induced IL-6 production by PDL cells, although it completely inhibited IL-1alpha-induced PGE2 production.	Dinoprostone	144-148	interleukin 1 alpha	Homo sapiens	126-135
15888106-8	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced IL-6 production, although 17-phenyl-omega-trinor PGE2, an EP1 agonist, and ONO-AP-324, an EP3 agonist, did not affect it.	ONO-AE1-329	40-51	interleukin 1 alpha	Homo sapiens	102-111
15888106-8	2005	Butaprost, a selective EP2 agonist, and ONO-AE1-329, a selective EP4 agonist, significantly inhibited IL-1alpha-induced IL-6 production, although 17-phenyl-omega-trinor PGE2, an EP1 agonist, and ONO-AP-324, an EP3 agonist, did not affect it.	ONO AP 324	195-205	interleukin 1 alpha	Homo sapiens	102-111
15888106-10	2005	CONCLUSIONS: We suggest that PGE2 downregulates IL-1alpha-induced IL-6 production via EP2/EP4 receptors in human PDL cells.	Dinoprostone	29-33	interleukin 1 alpha	Homo sapiens	48-57
34904767-9	2022	Viral ssRNA inhibited aPL-induced uric acid, IL-1beta and sFlt-1 secretion, and further exacerbated aPL-inhibition of trophoblast migration.	ssrna	6-11	interleukin 1 alpha	Homo sapiens	45-53
34766707-3	2022	We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18.	Silicon Dioxide	72-78	interleukin 1 alpha	Homo sapiens	266-274
34766707-3	2022	We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18.	Silicon Dioxide	149-155	interleukin 1 alpha	Homo sapiens	266-274
34688696-10	2022	KEY FINDINGS: Our results showed that quercetin prevented THP-1 macrophage pyroptosis by reducing the expression of NLRP3 and cleaved-caspase1, as well as IL-1beta and N-GSDMD in a concentration dependent manner.	Quercetin	38-47	interleukin 1 alpha	Homo sapiens	155-163
34919143-5	2022	Mechanistically, cancer cell-derived IL-1beta enhances Marco expression on macrophages, and reciprocally, cancer cell migration is promoted by CCL6 released by lipid-loaded TAMs.	ccl6	143-147	interleukin 1 alpha	Homo sapiens	37-45
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Phosphoserine	13-18	interleukin 1 alpha	Homo sapiens	87-95
34730058-9	2022	The level of miR-144-3p in N1511 cells was upregulated by IL-1beta.	mir-144-3p	13-23	interleukin 1 alpha	Homo sapiens	58-66
34730058-10	2022	MiR-144-3p knockdown inhibited IL-1beta-induced pyroptosis in N1511 cells, and the expressions of NOD-like receptor family pyrin domain containing 3 (NLRP3), Cleaved caspase-1, Gasdermin D (GSDMD), and Cleaved caspase-3 in IL-1beta-stimulated N1511 cells were increased.	mir-144-3p	0-10	interleukin 1 alpha	Homo sapiens	31-39
34730058-10	2022	MiR-144-3p knockdown inhibited IL-1beta-induced pyroptosis in N1511 cells, and the expressions of NOD-like receptor family pyrin domain containing 3 (NLRP3), Cleaved caspase-1, Gasdermin D (GSDMD), and Cleaved caspase-3 in IL-1beta-stimulated N1511 cells were increased.	mir-144-3p	0-10	interleukin 1 alpha	Homo sapiens	223-231
34730058-11	2022	The levels of inflammatory cytokines in N1511 cells were increased by IL-1beta, which were restored by miR-144-3p knockdown.	mir-144-3p	103-113	interleukin 1 alpha	Homo sapiens	70-78
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Formaldehyde	33-41	interleukin 1 alpha	Homo sapiens	87-95
34657305-7	2022	In addition, L-SOP decreased the formalin-induced upregulation of TNF-alpha as well as IL-1beta expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin-induced nociception through inhibition of the pro-inflammatory cytokines in the spinal cord.	Formaldehyde	193-201	interleukin 1 alpha	Homo sapiens	87-95
34387888-2	2022	In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1beta derived from activated hepatic macrophages to suppress hepatocyte FXR signaling and promote PNAC.	pnac	3-7	interleukin 1 alpha	Homo sapiens	73-81
34387888-2	2022	In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1beta derived from activated hepatic macrophages to suppress hepatocyte FXR signaling and promote PNAC.	Phytosterols	9-20	interleukin 1 alpha	Homo sapiens	73-81
34427852-5	2022	Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2).	Glycyrrhizic Acid	24-26	interleukin 1 alpha	Homo sapiens	132-140
34387888-2	2022	In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1beta derived from activated hepatic macrophages to suppress hepatocyte FXR signaling and promote PNAC.	pnac	174-178	interleukin 1 alpha	Homo sapiens	73-81
34923420-0	2022	Differential regulation of lipopolysaccharide-induced IL-1beta and TNF-alpha production in macrophages by palmitate via modulating TLR4 downstream signaling.	Palmitates	106-115	interleukin 1 alpha	Homo sapiens	54-62
34613549-0	2022	Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1beta-Induced Inflammation by Blocking MAPK/NF-kappaB Signaling Pathways.	oleuropein	0-10	interleukin 1 alpha	Homo sapiens	64-72
34923420-12	2022	The differential regulation of LPS-induced TNF-alpha and IL-1beta production by PA was associated with cellular metabolism of PA, because inhibiting metabolism of PA with etomoxir or pretreatment with Br-PA which cannot be metabolized reversed these effects.	Palmitic Acid	80-82	interleukin 1 alpha	Homo sapiens	57-65
34923420-7	2022	In contrast, LPS-induced IL-1beta production and secretion was significantly suppressed by PA pretreatment.	Palmitic Acid	91-93	interleukin 1 alpha	Homo sapiens	25-33
34923420-12	2022	The differential regulation of LPS-induced TNF-alpha and IL-1beta production by PA was associated with cellular metabolism of PA, because inhibiting metabolism of PA with etomoxir or pretreatment with Br-PA which cannot be metabolized reversed these effects.	Palmitic Acid	126-128	interleukin 1 alpha	Homo sapiens	57-65
34875574-8	2022	LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling.	Acetylmuramyl-Alanyl-Isoglutamine	14-17	interleukin 1 alpha	Homo sapiens	29-37
34923420-12	2022	The differential regulation of LPS-induced TNF-alpha and IL-1beta production by PA was associated with cellular metabolism of PA, because inhibiting metabolism of PA with etomoxir or pretreatment with Br-PA which cannot be metabolized reversed these effects.	etomoxir	171-179	interleukin 1 alpha	Homo sapiens	57-65
34923420-15	2022	PA differentially affected LPS-induced production of TNF-alpha and IL-1beta in macrophages through differentially modulating these pathways.	Palmitic Acid	0-2	interleukin 1 alpha	Homo sapiens	67-75
34929480-7	2022	Further, POH treatment has decreased the pro-inflammatory serum cytokine levels such as IL-6, IL-12/23, TNF-alpha and IL-1beta and also reduced the expression levels of various inflammatory proteins, COX-2, iNOS, IL-17A, IL-22, NF-kB and STAT3 evidenced by Immunoblotting studies from skin samples.	perillyl alcohol	9-12	interleukin 1 alpha	Homo sapiens	118-126
34875574-8	2022	LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling.	ros	190-193	interleukin 1 alpha	Homo sapiens	29-37
34875574-11	2022	FM IL-1beta secretion was inhibited by allopurinol, which blocks uric acid production, for LPS and PGN, and to a lesser degree, MDP.	Allopurinol	39-50	interleukin 1 alpha	Homo sapiens	3-11
34875574-11	2022	FM IL-1beta secretion was inhibited by allopurinol, which blocks uric acid production, for LPS and PGN, and to a lesser degree, MDP.	Uric Acid	65-74	interleukin 1 alpha	Homo sapiens	3-11
34673277-7	2022	In vitro study revealed that TMAO directly induced primary peritoneal mesothelial cell necrosis, together with increased production of pro-inflammatory cytokines including CCL2, TNF-alpha, IL-6 and IL-1beta.	trimethyloxamine	29-33	interleukin 1 alpha	Homo sapiens	198-206
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	interleukin 1 alpha	Homo sapiens	112-120
34785106-9	2022	Furthermore, ISL promoted fatty acid metabolism via induction in the expression of PGC-1alpha-target genes PPARalpha, CPT1alpha, and ACADs, and inhibited the ROS, TNF-alpha, IL-1beta, and IL-6 expression.	Fatty Acids	26-36	interleukin 1 alpha	Homo sapiens	174-182
34753005-3	2022	We demonstrate that the brartemicin amide derivatives activate bone-marrow-derived macrophages (BMDMs) in a Mincle-dependent manner, as evidenced by the production of the pro-inflammatory cytokine IL-1beta in wildtype but not Mincle-/- cells.	brartemicin amide	24-41	interleukin 1 alpha	Homo sapiens	197-205
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	interleukin 1 alpha	Homo sapiens	115-123
34843717-0	2022	Luxeptinib Disables NLRP3 Inflammasome-Mediated IL-1beta release and Pathways Required for Secretion of Inflammatory Cytokines IL-6 and TNFalpha.	Luxeptinib	0-10	interleukin 1 alpha	Homo sapiens	48-56
34843717-6	2022	The aim of this study was to determine the extent to which luxeptinib interferes with the release of IL-1beta, IL-6 and TNFalpha from THP-1 monocytes and bone marrow-derived macrophages following endotoxin exposure and priming of the NLRP3 inflammasome.	Luxeptinib	59-69	interleukin 1 alpha	Homo sapiens	101-109
34843717-8	2022	Investigation of the mechanism disclosed that luxeptinib does not inhibit the assembly of the NLRP3 inflammasome but disables its ability to cleave and activate caspase-1 that is required for IL-1beta release.	Luxeptinib	46-56	interleukin 1 alpha	Homo sapiens	192-200
34843717-10	2022	Implications: The ability of luxeptinib to inhibit the NLRP3-mediated release of IL-1beta and pathways involved in the release of IL-6 and TNFalpha at concentrations which are well-tolerated in patients makes it a candidate for the treatment of inflammatory diseases and inflammation-associated resistance in cancer.	Luxeptinib	29-39	interleukin 1 alpha	Homo sapiens	81-89
34922939-9	2022	The induction of ROS affected the level of proinflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Reactive Oxygen Species	17-20	interleukin 1 alpha	Homo sapiens	88-96
34881566-9	2022	Furthermore, cell experiments demonstrated that such glyco-nanostructures can further facilitate the functions of a model drug of the pyridone agent to reduce the expression of monocyte chemotactic protein-1 (MCP-1) and interleukin -1beta (IL-1beta) in the primary peritoneal macrophages via encapsulating drugs.	Pyridones	134-142	interleukin 1 alpha	Homo sapiens	240-248
34904823-5	2022	PA treatment suppresses the nuclear translocation of NF-kappaB, enhances PARKIN translocation into the mitochondria, and maintains cellular redox homeostasis in both mouse and human microglial cells that limit NLRP3 inflammasome activation along with processing of active caspase-1, IL-1beta, and IL-18.	perillyl alcohol	0-2	interleukin 1 alpha	Homo sapiens	283-291
34753005-5	2022	Two of the amide derivatives, but none of the ester-derivatives, also led to the production of IL-1beta by human-derived monocytes.	Amides	11-16	interleukin 1 alpha	Homo sapiens	95-103
34753005-5	2022	Two of the amide derivatives, but none of the ester-derivatives, also led to the production of IL-1beta by human-derived monocytes.	Esters	46-51	interleukin 1 alpha	Homo sapiens	95-103
34753005-6	2022	As the production of IL-1beta is a good indicator of vaccine adjuvanticity potential, these findings suggest that amide-linked brartemicin derivatives show particular promise as vaccine adjuvants.	brartemicin	127-138	interleukin 1 alpha	Homo sapiens	21-29
34696918-7	2022	Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2.	Hydrogen Peroxide	15-19	interleukin 1 alpha	Homo sapiens	94-102
34696918-7	2022	Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2.	Hydrogen Peroxide	151-155	interleukin 1 alpha	Homo sapiens	94-102
34696918-6	2022	Placental explants from NT cultured with H2O2 showed increased gene and protein expression of NLRP1, NLRP3, caspase-1, IL-1beta, TNF-alpha and HMGB1, while H2O2 was also able to increase TNF-alpha and caspase-1 gene expression in PE.	Hydrogen Peroxide	41-45	interleukin 1 alpha	Homo sapiens	119-127
34591282-6	2022	By immunohistochemistry, IL-1beta expression was seen on TAMs, especially in perinecrotic areas.	tams	57-61	interleukin 1 alpha	Homo sapiens	25-33
34774714-6	2022	Chronic morphine treatments for 7 days reduced the protein expression of MKP-1 and MKP-3 in the spinal cord and increased the phosphorylation of p38, ERK1/2 and the level of proinflammatory mediator, such as IL-1beta, IL-6 and TNF-alpha.	Morphine	8-16	interleukin 1 alpha	Homo sapiens	208-216
34848238-3	2022	Besides, feruloylated AX (50-1000 mug/mL) markedly downregulated the mRNA expressions of NO, IL-1beta, TNF-alpha, IL-6, and IL-23a, and reduced the phosphorylation levels of p38, ERK, and JNK in M1.	arabinoxylan	22-24	interleukin 1 alpha	Homo sapiens	93-101
34883226-3	2022	Through cell culture, virus infection, and RT-qPCR, we found that LiCl could down-regulate the apoptosis-related genes Caspase-3 and Bax, up-regulate Bcl-2, and down-regulate the inflammatory-related genes (NF-kappaB, NLRP3, TNF-alpha, and IL-1beta) via inhibiting virus replication.	Lithium Chloride	66-70	interleukin 1 alpha	Homo sapiens	240-248
34651203-15	2022	HIF-1 activation increased IL-1beta and IL-8 in human uroepithelial cells treated with high glucose concentration.	Glucose	92-99	interleukin 1 alpha	Homo sapiens	27-35
34826552-6	2022	Treatment with norfloxacin down-regulated Leptospira-induced IL-1beta and TNF-alpha both in vivo and vitro models.	Norfloxacin	15-26	interleukin 1 alpha	Homo sapiens	61-69
34965405-9	2022	NLRP3, caspase-1 and IL1-beta expression significantly increased in human lens cells exposed to H2O2 or irradiated with white LED light.	Hydrogen Peroxide	96-100	interleukin 1 alpha	Homo sapiens	21-29
34785108-16	2022	In vivo and in vitro, YDJDG exerted anti-inflammatory effects by inhibiting the production of inflammatory cytokines (IL-6, IL-1beta, and TNF-alpha).	ydjdg	22-27	interleukin 1 alpha	Homo sapiens	124-132
34864233-0	2022	Fluoxetine modulates the pro-inflammatory process of IL-6, IL-1beta and TNF-alpha levels in individuals with depression: a systematic review and meta-analysis.	Fluoxetine	0-10	interleukin 1 alpha	Homo sapiens	59-67
34864233-3	2022	Hence, our aim was to perform a meta-analysis and systematic review to understand the interaction of fluoxetine in the IL-1beta, IL-6 and TNF-alpha inflammatory process.	Fluoxetine	101-111	interleukin 1 alpha	Homo sapiens	119-127
34864233-8	2022	In conclusion, the pooled data suggest that fluoxetine treatment improved depressive symptomatology by the modulation of pro-inflammatory process such as IL-1beta, IL-6 or TNF-alpha.	Fluoxetine	44-54	interleukin 1 alpha	Homo sapiens	154-162
34719371-5	2021	In particular, ALA is able to reduce inflammasome activity, the pro-inflammatory cytokine levels, such as TNF-alpha, IL-1beta, IL-6, IL-18 and IL-17, interferon (INF)-gamma as well as the production of Vascular and Intercellular cell adhesion protein (VCAM-1 and ICAM-1).	Thioctic Acid	15-18	interleukin 1 alpha	Homo sapiens	117-125
34801680-7	2022	Treatment of wounded skin with MEL-DCL nano-complexes showed significant reduction of IL-6, IL-1beta, and TNF-alpha pro-inflammatory markers that was paralleled by a substantial increase in mRNA expression levels of collagen, type I, alpha 1 (Col1A1) and collagen, type IV, alpha 1 (Col4A1), and hydroxyproline content as compared to individual drugs.	mel-dcl	31-38	interleukin 1 alpha	Homo sapiens	92-100
34974155-6	2022	The moderate to high survivability demonstrated by the Sa-adjuvanted IV vaccine, was substantiated by the significant (p < 0.05) upregulation of IL-1beta, Mx and PKR gene transcript.	Saponins	55-57	interleukin 1 alpha	Homo sapiens	145-153
34704529-0	2022	Low Deacetylation Degree Chitosan Oligosaccharide Protects against IL-1beta Induced Inflammation and Enhances Autophagy Activity in Human Chondrocytes.	D-Glucosaminide	25-49	interleukin 1 alpha	Homo sapiens	67-75
34937520-6	2021	Compared to the NT group, the endogenous levels of IL-1beta, TNF-alpha, and IL-18 were higher in the PE group.	nt	16-18	interleukin 1 alpha	Homo sapiens	51-59
34935985-4	2022	In both differentiated and non-differentiated human monocytic THP-1 cells, clozapine, but not its structural analogues fluperlapine and olanzapine, caused inflammasome-dependent caspase-1 activation and IL-1beta release that was inhibited using the caspase-1 inhibitor yVAD-cmk.	Clozapine	75-84	interleukin 1 alpha	Homo sapiens	203-211
34935985-4	2022	In both differentiated and non-differentiated human monocytic THP-1 cells, clozapine, but not its structural analogues fluperlapine and olanzapine, caused inflammasome-dependent caspase-1 activation and IL-1beta release that was inhibited using the caspase-1 inhibitor yVAD-cmk.	YVAD	269-273	interleukin 1 alpha	Homo sapiens	203-211
34704529-6	2022	In this study, we explored the protective effects of COS with different degrees of deacetylation on chondrocytes stimulated by interleukin 1beta (IL-1beta) in vitro.The results showed that IL-1beta inhibited cell proliferation and promoted cell apoptosis.	carbonyl sulfide	53-56	interleukin 1 alpha	Homo sapiens	189-197
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	Adenosine	39-48	interleukin 1 alpha	Homo sapiens	224-232
34988139-10	2021	In addition, SGDL granule + doxycycline effectively inhibited IBV replication and stopped IBV propagation from the trachea to the lung; modulated the mRNA expressions of IL-1beta, IL-6, TNF-alpha, and IFN-gamma; and extenuated the histopathology lesions in trachea and lung.	Doxycycline	28-39	interleukin 1 alpha	Homo sapiens	170-178
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	lipo-rsv	13-21	interleukin 1 alpha	Homo sapiens	141-149
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	ros	37-40	interleukin 1 alpha	Homo sapiens	141-149
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	acadesine	342-347	interleukin 1 alpha	Homo sapiens	224-232
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	Adenosine Monophosphate	64-67	interleukin 1 alpha	Homo sapiens	224-232
34930349-5	2021	RESULTS: Following stimulation by IL-1beta, the production of IL-8, MCP-1, PGE2 and PGF2alpha showed significant increases, and these increases were suppressed by AICAR.	Dinoprostone	75-79	interleukin 1 alpha	Homo sapiens	34-42
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	Dinoprostone	184-200	interleukin 1 alpha	Homo sapiens	224-232
34930349-5	2021	RESULTS: Following stimulation by IL-1beta, the production of IL-8, MCP-1, PGE2 and PGF2alpha showed significant increases, and these increases were suppressed by AICAR.	Dinoprost	84-93	interleukin 1 alpha	Homo sapiens	34-42
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	f2alpha	205-212	interleukin 1 alpha	Homo sapiens	224-232
34930349-8	2021	CONCLUSIONS: The production of IL-8, MCP-1, PGE2 and PGF2alpha induced by IL-1beta in ESCs were involved in the negative regulatory mechanisms of AMPK.	Dinoprostone	44-48	interleukin 1 alpha	Homo sapiens	74-82
34930349-8	2021	CONCLUSIONS: The production of IL-8, MCP-1, PGE2 and PGF2alpha induced by IL-1beta in ESCs were involved in the negative regulatory mechanisms of AMPK.	Dinoprost	53-62	interleukin 1 alpha	Homo sapiens	74-82
34916261-7	2021	RESULTS: Patients with atopic asthma had increased induction of IL-4, IFN-beta, IL-6, TNF-alpha, and IL-1beta after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma.	Poly I-C	116-126	interleukin 1 alpha	Homo sapiens	101-109
34977169-8	2021	Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1beta), interleukin 6 (IL-6), and interleukin 8 (IL-8).	aedppe	9-15	interleukin 1 alpha	Homo sapiens	144-152
34800541-7	2021	The adverse effects of IL-1beta on TJs were mimicked by anisomycin, which is an activator of p38 and JNK signalling, and were blocked by MEC pretreatment with a p38 inhibitor but not a JNK inhibitor.	Anisomycin	56-66	interleukin 1 alpha	Homo sapiens	23-31
34908254-8	2021	Hyperglycemia also increases serum Nitric Oxide (NO), which decreases neutrophil motility and reduces the synthesis and release of various inflammatory mediators such as TNF-alpha and IL-1beta, IL-6.	Nitric Oxide	35-47	interleukin 1 alpha	Homo sapiens	184-192
34500224-6	2021	Surprisingly, through MIF/IL-1beta biosensors, we angled 5-O-methylvisammioside, amygdalin, and cimicifugoside three CQAs.	5-O-Methylvisammioside	57-79	interleukin 1 alpha	Homo sapiens	26-34
34956386-7	2021	What is more, upregulated protein expression of p-IKKalpha/beta, p-NF-kappaB p65, NLRP3, cleaved caspase 1, and mature IL-1beta occurred in HepG2 cells in response to PA stress while rescued with the PCB2 intervention.	Protactinium	167-169	interleukin 1 alpha	Homo sapiens	119-127
34956386-8	2021	In conclusion, our study demonstrated that PA induces ERS in HepG2 cells and subsequently activates downstream NLRP3 inflammasome-mediated cellular injury, while PCB2 inhibits NLRP3/caspase 1/IL-1beta pathway, inflammation, and apoptosis with the presence of ERS, thereby promoting cell survival, which may provide pharmacological evidence for clinical approaches on NAFLD.	Protactinium	43-45	interleukin 1 alpha	Homo sapiens	192-200
34922061-9	2021	After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls.	Anthocyanins	6-17	interleukin 1 alpha	Homo sapiens	100-108
34922061-9	2021	After anthocyanin administration, both mRNA expression of NLRP3 inflammasome components (caspase-1, IL-1beta, and IL-18) in PBMCs and plasma levels of IL-1beta and IL-18 decreased dramatically in NAFLD patients compared with controls.	Anthocyanins	6-17	interleukin 1 alpha	Homo sapiens	151-159
34800541-7	2021	The adverse effects of IL-1beta on TJs were mimicked by anisomycin, which is an activator of p38 and JNK signalling, and were blocked by MEC pretreatment with a p38 inhibitor but not a JNK inhibitor.	mec	137-140	interleukin 1 alpha	Homo sapiens	23-31
34752597-3	2021	Butyrate enters the cells through the Solute Carrier Family 5 Member 8 (SLC5A8) transporters, then works as a histone deacetylase inhibitor (HDAC) that inhibits the activation of Nuclear factor-kappaB (NF-kappaB), which down-regulates the expression of IL-1beta, IL-6, TNF-alpha.	Butyrates	0-8	interleukin 1 alpha	Homo sapiens	253-261
34975889-0	2021	Antcin K Inhibits TNF-alpha, IL-1beta and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis.	antcin K	0-8	interleukin 1 alpha	Homo sapiens	29-37
34975889-3	2021	In our analysis of the mechanism of action, Antcin K inhibited the expression of three cytokines (tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and IL-8) in human RASFs; cytokines that are crucial to RA synovial inflammation.	antcin K	44-52	interleukin 1 alpha	Homo sapiens	159-167
34975889-6	2021	The inhibitory effects of Antcin K upon TNF-alpha, IL-1beta and IL-8 expression in human RASFs was achieved through the downregulation of the FAK, PI3K, AKT and NF-kappaB signaling cascades.	antcin K	26-34	interleukin 1 alpha	Homo sapiens	51-59
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	interleukin 1 alpha	Homo sapiens	25-33
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	interleukin 1 alpha	Homo sapiens	119-127
34966295-6	2021	Another common denominator in the pathogenesis of insulin resistance, hypertension, and salt sensitivity (SS) is immune activation involving pro-inflammatory cytokines like tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-6.	Salts	88-92	interleukin 1 alpha	Homo sapiens	208-216
34890370-5	2021	RESULTS: In all studied women, the levels of IL-1beta significantly positively correlated with Ca, Mg, and Sr; IFNgamma significantly negatively correlated with Sr, and IL-6 with Mg.	Magnesium	99-101	interleukin 1 alpha	Homo sapiens	45-53
34884940-6	2021	Moreover, miR-485-3p ASO treatment reduced secretion of proinflammatory cytokines, including IL-1beta and TNF-alpha, and eventually relieved cognitive impairment.	mir-485-3p	10-20	interleukin 1 alpha	Homo sapiens	93-101
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Imiquimod	0-9	interleukin 1 alpha	Homo sapiens	78-86
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	interleukin 1 alpha	Homo sapiens	78-86
34876117-11	2021	Allergen-induced sputum IL-1beta production was significantly associated with sputum and blood IL-5 (p < 0.001 and p = 0.007, respectively), sputum IL-4 (p = 0.001), IL-13 (p = 0.026), eosinophils (p = 0.008) and FeNO (p = 0.03).	feno	213-217	interleukin 1 alpha	Homo sapiens	24-32
34866234-8	2022	CONCLUSION: High dose ascorbic acid was associated with significantly reduced oxidative stress, reduced pro-inflammatory markers except IL-1beta, elevated anti-inflammatory marker, and elevated plasma VC levels.	Ascorbic Acid	22-35	interleukin 1 alpha	Homo sapiens	136-144
34884940-6	2021	Moreover, miR-485-3p ASO treatment reduced secretion of proinflammatory cytokines, including IL-1beta and TNF-alpha, and eventually relieved cognitive impairment.	Oligonucleotides, Antisense	21-24	interleukin 1 alpha	Homo sapiens	93-101
34560176-10	2021	Also, our results strongly suggested that BF4 also inhibits the endogenous cellular PC1/3 activity in Caco-2 cells, since PC1/3 inhibition by BF4 causes a large increase in IL-8 and IL-1beta secretion in Caco-2 cells.	fluoroboric acid	142-145	interleukin 1 alpha	Homo sapiens	182-190
34876290-9	2022	Dimethyl itaconate upregulated IL-1beta at 24 hours (FC 18.00 at D4, P <= .001).	dimethyl itaconate	0-18	interleukin 1 alpha	Homo sapiens	31-39
34343639-9	2021	Finally, INCA-6 rescued IL-1beta-induced permeability in both hRMEC monolayers in vitro and an acute model of retinal inflammation in vivo.	INCA-6	9-15	interleukin 1 alpha	Homo sapiens	24-32
34560176-10	2021	Also, our results strongly suggested that BF4 also inhibits the endogenous cellular PC1/3 activity in Caco-2 cells, since PC1/3 inhibition by BF4 causes a large increase in IL-8 and IL-1beta secretion in Caco-2 cells.	fluoroboric acid	42-45	interleukin 1 alpha	Homo sapiens	182-190
34943044-6	2021	We found, in both RAW 264.7 cells and HaCaT cells, MAEO inhibited LPS-stimulated inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 and proinflammatory cytokines, including IL-1beta and IL-6, due to the suppression of COX-2 and iNOS expression.	maeo	51-55	interleukin 1 alpha	Homo sapiens	192-200
34944461-6	2021	RESULTS: NTZ exerts an inhibitory effect on the cell proliferation of T lymphocytes stimulated with anti-CD3 and anti-CD28 antibodies without modifying cell viability, and significant decreases in the supernatant concentrations of interleukin (IL)-1beta, IL-2, IL-6, IL-10, and IL-12.	nitazoxanide	9-12	interleukin 1 alpha	Homo sapiens	231-253
34856990-13	2021	Furthermore, there was a positive correlation between the IL-1beta level in plasma and CSF of aMCI or AD patients.	amci	94-98	interleukin 1 alpha	Homo sapiens	58-66
34856990-16	2021	In addition, the proinflammatory cytokine IL-1beta was strongly associated with the pathophysiology of aMCI and AD.	amci	103-107	interleukin 1 alpha	Homo sapiens	42-50
34226664-8	2021	Moreover, darapladib substantially reduced the Ang II infusion-induced expression of nucleotide-binding oligomerization domain-like receptor with pyrin domain 3 (NLRP3) and interleukin (IL)-1beta and markedly attenuated caspase-1 activation in cardiac tissues.	darapladib	10-20	interleukin 1 alpha	Homo sapiens	173-195
34226664-9	2021	Furthermore, darapladib ameliorated Ang II-stimulated macrophage migration and IL-1beta secretion in macrophages by blocking NLRP3 inflammasome activation.	darapladib	13-23	interleukin 1 alpha	Homo sapiens	79-87
34180760-15	2021	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.	mir-183-5p	130-140	interleukin 1 alpha	Homo sapiens	433-441
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	interleukin 1 alpha	Homo sapiens	107-115
34288819-0	2021	Anagliptin prevented interleukin 1beta (IL-1beta)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).	anagliptin	0-10	interleukin 1 alpha	Homo sapiens	40-48
34288819-5	2021	Here, the beneficial effect of Anagliptin against interleukin 1beta (IL-1beta)-induced cell senescence in vascular smooth muscle cells was studied to learn the promising therapeutic capacity of Anagliptin on atherosclerosis.	anagliptin	31-41	interleukin 1 alpha	Homo sapiens	69-77
34288819-7	2021	Secondly, our findings indicate that exposure to IL-1beta reduced telomerase activity from 26.7 IU/L to 15.8 IU/L, which was increased to 20.3 and 24.6 IU/L by 2.5 and 5 muM Anagliptin, respectively.	anagliptin	174-184	interleukin 1 alpha	Homo sapiens	49-57
34288819-8	2021	In contrast, IL-1beta stimulation increased senescence- associated beta-galactosidase (SA-beta-gal) staining to 3.1- fold compared to the control group, it was then reduced to 2.3- and 1.6- fold by Anagliptin dose-dependently.	anagliptin	198-208	interleukin 1 alpha	Homo sapiens	13-21
34338149-7	2021	Furthermore, the activated NLRP3 inflammasome and the excessive production of interleukin 18 (IL-18) and interleukin 1beta (IL-1beta) in HrGECs induced by incubation with HG were pronouncedly reversed by the introduction of Omarigliptin, accompanied by the activation of the AMPK/mTOR signaling pathway.	2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine	224-236	interleukin 1 alpha	Homo sapiens	124-132
34288819-9	2021	Thirdly, Anagliptin dramatically reversed the upregulated p16, p21, and downregulated sirtuin1 (SIRT1) in IL-1beta-treated vascular smooth muscle cells.	anagliptin	9-19	interleukin 1 alpha	Homo sapiens	106-114
34427537-0	2021	The protective effects of naproxen against interleukin-1beta (IL-1beta)- induced damage in human umbilical vein endothelial cells (HUVECs).	Naproxen	26-34	interleukin 1 alpha	Homo sapiens	62-70
34414854-10	2021	Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) in H2O2-stimulated cells (P < 0.001).	Hydrogen Peroxide	226-230	interleukin 1 alpha	Homo sapiens	213-221
34427537-5	2021	Our findings indicate that naproxen could protect against IL-1beta-induced damage by improving cell viability and preventing cell death.	Naproxen	27-35	interleukin 1 alpha	Homo sapiens	58-66
34858005-8	2021	When PA was added to cultured human sebocytes, caspase-1 activation and IL-1beta secretion were significantly enhanced.	Palmitic Acid	5-7	interleukin 1 alpha	Homo sapiens	72-80
34427537-6	2021	Additionally, naproxen suppressed the expression of the cytokines IL-6, IL-12, and tumor necrosis factor-alpha (TNF-alpha), and downregulated the expression of vascular endothelial growth factor (VEGF) and tissue factor (TF) induced by IL-1beta.	Naproxen	14-22	interleukin 1 alpha	Homo sapiens	236-244
34858005-9	2021	In addition, NLRP3 knockdown attenuated IL-1beta production by sebocytes stimulated with PA.	Palmitic Acid	89-91	interleukin 1 alpha	Homo sapiens	40-48
34374483-8	2021	Although exogenous PGE2 upregulated macrophage pro-IL-1beta expression, it suppressed the secretion of cleaved IL-1beta.	Dinoprostone	19-23	interleukin 1 alpha	Homo sapiens	51-59
34506261-8	2021	Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate.	Argon	0-5	interleukin 1 alpha	Homo sapiens	291-299
34374483-8	2021	Although exogenous PGE2 upregulated macrophage pro-IL-1beta expression, it suppressed the secretion of cleaved IL-1beta.	Dinoprostone	19-23	interleukin 1 alpha	Homo sapiens	111-119
34374483-10	2021	Co-treatment of macrophages with HGF and PGE2 reduced pro-IL-1beta expression level and active IL-1beta secretion.	Dinoprostone	41-45	interleukin 1 alpha	Homo sapiens	95-103
34546593-10	2021	In PI vs PM, significantly higher REL was found for Hey 1, TNF-alpha, IL-17, IL-1beta, IL-6 and RANKL.	pipermethystine	9-11	interleukin 1 alpha	Homo sapiens	77-85
34624172-2	2021	Besides the antimicrobial activities against bacteria, fungi and viruses, Ala has also demonstrated significant anti-inflammatory effects in various models by inhibiting NF-kappaB and MAPKs to decrease the pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha.	alantolactone	74-77	interleukin 1 alpha	Homo sapiens	241-249
34717170-3	2021	This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy.	Levetiracetam	95-108	interleukin 1 alpha	Homo sapiens	178-186
34459104-8	2021	Treatment of HFLS-RA cells with OMTH prevented TNF-alpha mediated elevation of IL-1beta, IL-6 and IL-8.	omth	32-36	interleukin 1 alpha	Homo sapiens	79-87
34925366-1	2021	Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta.	Uric Acid	20-36	interleukin 1 alpha	Homo sapiens	101-109
34500361-10	2021	The selected inflammatory biomarkers were positively, while the postnatal PFAS were negatively related with the included cardiometabolic factors, and only prenatal PFOA was positively related with the pro-inflammatory cytokine IL-1beta and WC.	perfluorooctanoic acid	164-168	interleukin 1 alpha	Homo sapiens	227-235
34737801-10	2021	Vicenin 3 was found to significantly inhibit IL-1beta-induced production of NO and PGE.	Prostaglandins E	83-86	interleukin 1 alpha	Homo sapiens	45-53
34608806-7	2021	Therapeutically, TMF ameliorated the effects of IL-1beta.	methoxyluteolin	17-20	interleukin 1 alpha	Homo sapiens	48-56
34547383-12	2021	Meanwhile, DOX further increased the elevation of plasma IL-6, IL-1beta and TNF-alpha induced by DMM and obviously reduced the expression of chondrocyte differentiation-related markers, including collagen type II a1 (Col2A1), collagen type X alpha 1 (Col10A1), and aggrecan.	Doxorubicin	11-14	interleukin 1 alpha	Homo sapiens	63-71
34925018-4	2021	In this work, we found that IL-1beta-induced overexpression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin was inhibited by dauricine in primary human umbilical vein endothelial cells (HUVECs).	dauricine	183-192	interleukin 1 alpha	Homo sapiens	28-36
34925366-1	2021	Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta.	Uric Acid	38-41	interleukin 1 alpha	Homo sapiens	101-109
34925018-6	2021	Further studies showed that dauricine inhibited the activation of nuclear factor-kappaB (NF-kappaB) pathway in HUVECs stimulated with IL-1beta.	dauricine	28-37	interleukin 1 alpha	Homo sapiens	134-142
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	Uric Acid	40-43	interleukin 1 alpha	Homo sapiens	194-202
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	purine	53-59	interleukin 1 alpha	Homo sapiens	194-202
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	Adenosine	83-92	interleukin 1 alpha	Homo sapiens	194-202
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	Adenosine	107-116	interleukin 1 alpha	Homo sapiens	194-202
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	Adenosine	134-143	interleukin 1 alpha	Homo sapiens	194-202
34288020-14	2021	CONCLUSIONS: IL-1beta-induced SLC7A11 overexpression upregulated PD-L1 and CSF1 through alphaKG/HIF1alpha axis, which promoted TAMs and MDSCs infiltration.	tams	127-131	interleukin 1 alpha	Homo sapiens	13-21
34925366-4	2021	Recent studies have shown that, besides MSU, various purine metabolites, including adenosine triphosphate, adenosine diphosphate, and adenosine bind to different purine receptors for regulating IL-1beta secretion implicated in the pathogenesis of gout flares.	purine	162-168	interleukin 1 alpha	Homo sapiens	194-202
34925366-5	2021	Purine metabolites such as adenosine triphosphate mainly activate the NLRP3 inflammasome through P2X ion channel receptors, which stimulates IL-1beta secretion and induces gout flares, while some purine metabolites such as adenosine diphosphate and adenosine mainly act on the G protein-coupled receptors exerting pro-inflammatory or anti-inflammatory effects to regulate the onset and resolution of a gout flare.	purine	0-6	interleukin 1 alpha	Homo sapiens	141-149
34925366-5	2021	Purine metabolites such as adenosine triphosphate mainly activate the NLRP3 inflammasome through P2X ion channel receptors, which stimulates IL-1beta secretion and induces gout flares, while some purine metabolites such as adenosine diphosphate and adenosine mainly act on the G protein-coupled receptors exerting pro-inflammatory or anti-inflammatory effects to regulate the onset and resolution of a gout flare.	Adenosine	27-36	interleukin 1 alpha	Homo sapiens	141-149
34463587-3	2021	IL-1beta-induced chondrocyte was treated with A20 lentivirus activation particle, pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) with/without A20 siRNA.	pyrrolidine dithiocarbamic acid	82-109	interleukin 1 alpha	Homo sapiens	0-8
34509315-0	2021	Dopamine promotes the progression of AML via activating NLRP3 inflammasome and IL-1beta.	Dopamine	0-8	interleukin 1 alpha	Homo sapiens	79-87
34463587-3	2021	IL-1beta-induced chondrocyte was treated with A20 lentivirus activation particle, pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) with/without A20 siRNA.	pyrrolidine dithiocarbamic acid	111-115	interleukin 1 alpha	Homo sapiens	0-8
34509315-9	2021	Anti-IL-1beta antibody also could partly reversed the viability-enhancing effect by dopamine.	Dopamine	84-92	interleukin 1 alpha	Homo sapiens	5-13
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	interleukin 1 alpha	Homo sapiens	28-36
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	28-36
34562102-10	2021	In addition, IL-1beta and TNF-alpha instead of IL-6 in osteoarthritic IPFP-derived FCM played key roles in cartilage degradation via activating p38MAPK rather than ERK1/2 signaling pathway.	ipfp	70-74	interleukin 1 alpha	Homo sapiens	13-21
34710506-5	2021	IFN-gamma (100 ng/mL) plus poly (dA:dT) (2 mg/mL) induced the increased AURKA, secretion of IL-1beta, IL-18 and the active form of caspase-1 (p20).	poly(dA)	27-36	interleukin 1 alpha	Homo sapiens	92-100
34710506-5	2021	IFN-gamma (100 ng/mL) plus poly (dA:dT) (2 mg/mL) induced the increased AURKA, secretion of IL-1beta, IL-18 and the active form of caspase-1 (p20).	Thymidine	36-39	interleukin 1 alpha	Homo sapiens	92-100
34601327-2	2021	In our current study we sought to evaluate the in-vitro modulatory effect of nicotine, the principal alkaloid of tobacco, on nitric oxide (NO), interleukin 1beta (IL-1beta) and interleukin 37 (IL-37) production during Behcet"s disease.	Nicotine	77-85	interleukin 1 alpha	Homo sapiens	163-171
34607229-6	2021	Furthermore, the expression of platelet-activating factor receptor (PAFR) in astrocytes was induced by CPZ feeding and LPS stimulation, accompanied by the increase of inflammatory cytokines TNF-alpha,IL-6 and IL-1beta.	Cuprizone	103-106	interleukin 1 alpha	Homo sapiens	209-217
34562102-10	2021	In addition, IL-1beta and TNF-alpha instead of IL-6 in osteoarthritic IPFP-derived FCM played key roles in cartilage degradation via activating p38MAPK rather than ERK1/2 signaling pathway.	Fosfomycin	83-86	interleukin 1 alpha	Homo sapiens	13-21
34601327-6	2021	Our results showed that nicotine significantly reduced NO and IL-1beta levels in patients with Behcet"s disease, while it increased IL-37 production.	Nicotine	24-32	interleukin 1 alpha	Homo sapiens	62-70
34562102-11	2021	CONCLUSION: Osteoarthritic IPFP induces the degradation and inflammation of cartilage via activation of p38MAPK and ERK1/2 pathways, in which IL-1beta and TNF-alpha act as the key factors.	ipfp	27-31	interleukin 1 alpha	Homo sapiens	142-150
34768128-10	2021	RESULTS: CS resulted in shrinkage of endothelial cells, impaired aorta relaxation, reduced eNOS expression, and induced expression of iNOS, NLRP3, caspase-1p20 and IL-1beta, which could be prevented by knockdown of iNOS and NLRP3.	Cesium	9-11	interleukin 1 alpha	Homo sapiens	164-172
34704172-6	2021	ROCK is activated in the synovial of rheumatoid arthritis patients, while the blocking of ROCK with fasudil could also decrease IL-6, TNF-alpha, and IL-1.	fasudil	100-107	interleukin 1 alpha	Homo sapiens	149-153
34669001-6	2021	Many authors highlighted the activity of carvacrol as a potent suppressor of COX-2 expression minimizing the acute inflammatory process, decreasing the release of some pro-inflammatory mediators such as IL-1beta, TNF-alpha, PGE2.	carvacrol	41-50	interleukin 1 alpha	Homo sapiens	203-211
34813026-6	2021	PPARgamma agonists like pioglitazone increases the phagocytosis of Abeta and reduces inflammatory cytokine IL-1beta.	Pioglitazone	24-36	interleukin 1 alpha	Homo sapiens	107-115
34019775-6	2021	CoCl2 caused an increase of IL-8 in HaCaT cells, while the induction of also IL-13 and IL-1beta was observed in THP-1 cells and co-cultures.	cobaltous chloride	0-5	interleukin 1 alpha	Homo sapiens	87-95
34677731-7	2021	Eugenol also reduced SARS-CoV-2 spike S1-induced activation of NF-kappaB and the expression of IL-6, IL-1beta and TNFalpha in human A549 lung cells.	Eugenol	0-7	interleukin 1 alpha	Homo sapiens	101-109
34663512-6	2021	Moreover, AGE-induced inflammatory cytokines (IL-1beta and TNF-alpha) and their signaling through JAK2/STAT3 were blocked by PGG.	pentagalloylglucose	125-128	interleukin 1 alpha	Homo sapiens	46-54
34643253-8	2021	Similar in HPDE6C7 cells, CAE treatment caused supernatant IL-1beta level, NLRP3 and caspase-1 mRNA expression levels to significantly increase.	Ceruletide	26-29	interleukin 1 alpha	Homo sapiens	59-67
34719112-4	2021	For the first time, this paper reviews the evidence from in vitro and in vivo experimental models to explore the anti-inflammatory effects of BBR in periodontitis and exhibits that BBR has the high potency to exert anti-inflammatory effects by reducing expression and secretion of pro-inflammatory mediators including TNF-alpha, IL-1beta, IL-17, RANKL, MMP-2, MMP-9 and MCP-1.	Berberine	181-184	interleukin 1 alpha	Homo sapiens	329-337
34076913-6	2021	ELISA of BALF validated that ANI 654-2 decreased TNF-alpha, IL-1beta, IL-6 and IL-18 while increased IL-10.	1-Naphthylisothiocyanate	29-32	interleukin 1 alpha	Homo sapiens	60-68
34666245-0	2021	Trelagliptin ameliorates IL-1beta-impaired chondrocyte function via the AMPK/SOX-9 pathway.	trelagliptin	0-12	interleukin 1 alpha	Homo sapiens	25-33
34666245-6	2021	Here, we show that Trelagliptin mitigates IL-1beta-induced production of inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) in human chondrocytes.	trelagliptin	19-31	interleukin 1 alpha	Homo sapiens	42-50
34666245-7	2021	Trelagliptin ameliorates IL-1beta-induced oxidative stress by reducing the generation of reactive oxygen species (ROS).	trelagliptin	0-12	interleukin 1 alpha	Homo sapiens	25-33
34666245-7	2021	Trelagliptin ameliorates IL-1beta-induced oxidative stress by reducing the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	89-112	interleukin 1 alpha	Homo sapiens	25-33
34666245-7	2021	Trelagliptin ameliorates IL-1beta-induced oxidative stress by reducing the generation of reactive oxygen species (ROS).	Reactive Oxygen Species	114-117	interleukin 1 alpha	Homo sapiens	25-33
34666245-8	2021	Particularly, the presence of Trelagliptin prevents IL-1beta-induced reduction of Acan genes and the protein Aggrecan.	trelagliptin	30-42	interleukin 1 alpha	Homo sapiens	52-60
34666245-9	2021	Moreover, we show that Trelagliptin restores IL-1beta-induced reduction of SOX-9 and that the knockdown of SOX-9 abolishes the protective effects of Trelagliptin.	trelagliptin	23-35	interleukin 1 alpha	Homo sapiens	45-53
34666245-10	2021	Mechanistically, we demonstrate that AMPK is required for the amelioration of Trelagliptin on SOX-9- reduction by IL-1beta.	trelagliptin	78-90	interleukin 1 alpha	Homo sapiens	114-122
34537380-15	2021	Lastly, in OA hFLS, HU308 treatment inhibited IL-1beta-induced CCL2, MMP1, MMP3, and IL6 expression and further inhibited TNF-alpha-induced CCL2, MMP1, and GMCSF expression, demonstrating human OA-relevant anti-inflammatory effects by targeting CB2.	HU 308	20-25	interleukin 1 alpha	Homo sapiens	46-54
34697842-3	2021	Results of ELISA experiments revealed that Garcinia kola extract (6.25, 12.5, and 25 mug/ml) and garcinoic acid (1.25, 2.5, and 5 muM) significantly reduced SARS-CoV-2 spike protein S1-induced secretion of TNFalpha, IL-6, IL-1beta, and IL-8 in PBMCs.	garcinoic acid	97-111	interleukin 1 alpha	Homo sapiens	222-230
34726570-5	2021	RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs.	aps	9-12	interleukin 1 alpha	Homo sapiens	88-96
34643000-5	2021	CBD caused a parallel inhibition of interleukin 1 beta (IL-1beta), IL-6, tumor necrosis factor alpha (TNF-alpha), and IL-18 by enzyme-linked immunosorbent assay (ELISA) assay.	Cannabidiol	0-3	interleukin 1 alpha	Homo sapiens	56-64
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 1 alpha	Homo sapiens	234-242
34115723-7	2021	The benefit of olaparib and other clinically approved PARP inhibitors has already been demonstrated in several experimental models of human diseases, such as neurodegeneration and neuroinflammation, acute hepatitis, skeletal muscle disorders, aging and acute ischemic stroke, protecting, for example, from the deterioration of the blood-brain barrier, restoring the cellular levels of NAD+, improving mitochondrial function and biogenesis and, among other effects, reducing oxidative stress and pro-inflammatory mediators, such as TNF-alpha, IL1-beta, IL-6 and VCAM1.	olaparib	15-23	interleukin 1 alpha	Homo sapiens	542-550
34872043-0	2021	1,25-Dihydroxyvitamin D3 attenuates IL-1beta secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes.	Calcitriol	0-24	interleukin 1 alpha	Homo sapiens	36-44
34872043-5	2021	1,25(OH)2VD3 suppressed nigericin-induced interleukin-1beta (IL-1beta) secretion and caspase-1 activation in human primary keratinocytes.	Nigericin	24-33	interleukin 1 alpha	Homo sapiens	61-69
34872043-7	2021	Vitamin D receptor (VDR)-knockdown abolished the inhibitory effects of 1,25(OH)2VD3 on nigericin-induced ASC oligomerization and IL-1beta secretion, suggesting that 1,25(OH)2VD3 suppresses inflammasome activation via VDR signaling.	Nigericin	87-96	interleukin 1 alpha	Homo sapiens	129-137
34416289-7	2021	Lab made fluids with propylene glycol (PG) or PG plus a flavor chemical did not produce cytotoxic effects, but increased secretion of IL-1alpha and MMP-9, which was attributed to PG.	Propylene Glycol	46-48	interleukin 1 alpha	Homo sapiens	134-143
34416289-7	2021	Lab made fluids with propylene glycol (PG) or PG plus a flavor chemical did not produce cytotoxic effects, but increased secretion of IL-1alpha and MMP-9, which was attributed to PG.	Propylene Glycol	21-37	interleukin 1 alpha	Homo sapiens	134-143
34293432-5	2021	Our results showed that LPC significantly increased the levels of inflammatory cytokines (IL-1beta, IL-18, and IL-33) and markedly induced apoptosis and NLRP3 inflammasome activation in BMECs.	Lysophosphatidylcholines	24-27	interleukin 1 alpha	Homo sapiens	90-98
34416289-7	2021	Lab made fluids with propylene glycol (PG) or PG plus a flavor chemical did not produce cytotoxic effects, but increased secretion of IL-1alpha and MMP-9, which was attributed to PG.	Propylene Glycol	39-41	interleukin 1 alpha	Homo sapiens	134-143
34416289-7	2021	Lab made fluids with propylene glycol (PG) or PG plus a flavor chemical did not produce cytotoxic effects, but increased secretion of IL-1alpha and MMP-9, which was attributed to PG.	Propylene Glycol	179-181	interleukin 1 alpha	Homo sapiens	134-143
34668283-7	2021	Sirolimus appeared to be associated with a pro-inflammatory cytokine release, including TNF-alpha (p = 0.0027) and IL-1beta (p = 0.0016), in response to SARS-CoV-2 peptides.	Sirolimus	0-9	interleukin 1 alpha	Homo sapiens	115-123
34534743-0	2021	Gossypol ameliorates the IL-1beta-induced apoptosis and inflammation in chondrocytes by suppressing the activation of TLR4/MyD88/NF-kappaB pathway via downregulating CX43.	Gossypol	0-8	interleukin 1 alpha	Homo sapiens	25-33
34740670-0	2021	Cannabidiol selectively modulates interleukin (IL)-1beta and IL-6 production in toll-like receptor activated human peripheral blood monocytes.	Cannabidiol	0-11	interleukin 1 alpha	Homo sapiens	34-56
34740670-7	2021	CBD treatment significantly suppressed secretion of proinflammatory cytokine IL-1beta by monocytes activated through most TLRs, apart from TLRs 3 and 8.	Cannabidiol	0-3	interleukin 1 alpha	Homo sapiens	77-85
34846578-4	2022	Primary human OA chondrocytes in vitro respond to carbohydrate-inhibitable Gal-4 binding with the upregulation of pro-degradative/-inflammatory proteins such as interleukin-1beta (IL-1beta) and matrix metalloproteinase-13 (MMP-13), as documented by RT-qPCR-based mRNA profiling and transcriptome data processing.	Carbohydrates	50-62	interleukin 1 alpha	Homo sapiens	180-188
34917631-9	2021	A weak negative correlation (p < 0.05) between pO2 and serum IL-1beta, IL-12, and IL-33 and between SaO2 and serum IL-33 was noted.	PO-2	47-50	interleukin 1 alpha	Homo sapiens	61-69
34940303-11	2021	Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumour necrosis alpha (NF-kB, IL-6, IL-1beta, and TNF-alpha, respectively) were lower for ABX-NS compared to free ABX (p < 0.05).	Ambroxol	173-176	interleukin 1 alpha	Homo sapiens	119-127
34841579-8	2022	IL-1alpha and IL-1beta produced by activated human monocytes promote calcium mineralization and RUNX2 expression in fibro-adipogenic progenitors isolated from muscles surrounding NHOs.	Calcium	69-76	interleukin 1 alpha	Homo sapiens	0-9
34876829-12	2021	Moreover, using multivariate regression analysis, we showed that ONOO- and IL-1beta depended on cortisol level, while ONOO-, nitrotyrosine and HIF-1alpha were associated with aldosterone.	Hydrocortisone	96-104	interleukin 1 alpha	Homo sapiens	75-83
34841579-8	2022	IL-1alpha and IL-1beta produced by activated human monocytes promote calcium mineralization and RUNX2 expression in fibro-adipogenic progenitors isolated from muscles surrounding NHOs.	Calcium	69-76	interleukin 1 alpha	Homo sapiens	14-22
34847455-7	2022	We found an association of immune/inflammatory markers with Kyn/Trp ratio selectively in BD patients: IL-1beta and TNF-alpha showed a positive relationship and IL-2 and IL-9 a negative relationship; in addition, higher IL-4 correlated with lower Kyn levels; higher Kyn/Trp ratio and IL-1beta correlated with lower FA in the CC and IFO.	Kynurenine	60-63	interleukin 1 alpha	Homo sapiens	102-110
34847455-8	2022	Notably, the detrimental effect of IL-1beta on the IFO was moderated by the Kyn/Trp ratio.	ifo	51-54	interleukin 1 alpha	Homo sapiens	35-43
34847455-8	2022	Notably, the detrimental effect of IL-1beta on the IFO was moderated by the Kyn/Trp ratio.	Tryptophan	80-83	interleukin 1 alpha	Homo sapiens	35-43
34830460-6	2021	An analysis through Western blot showed an unexpected increase in IL-1beta-induced TAK1 phosphorylation-a prerequisite for and indicator of its functional potential-by takinib while simultaneously demonstrating the inhibition of the JAK/STAT pathway in human rheumatoid arthritis synovial fibroblasts (RASFs) in vitro.	takinib	168-175	interleukin 1 alpha	Homo sapiens	66-74
34933712-6	2021	Therefore, in the current study, the effect of borage oil was considered on the signaling pathway of the NLRP3 inflammasome complex, TLR4, and serum levels of inflammatory cytokines (IL-1? and IL-18) in type II diabetic patients with ARDS.	borage oil	47-57	interleukin 1 alpha	Homo sapiens	183-188
34933712-9	2021	The expression of NLRP3 and TLR4 genes (by Real-time PCR technique) and serum levels of IL-1? and IL-18 (by ELISA test) were evaluated before and after treatment with borage oil through blood samples taken from patients.	borage oil	167-177	interleukin 1 alpha	Homo sapiens	88-93
34933712-10	2021	The results showed that serum levels of inflammatory cytokines (IL-1? and IL-18), NLRP3 gene, and TLR4 gene were significantly decreased in diabetic type II patients with mild ARDS by treating with borage oil.	borage oil	198-208	interleukin 1 alpha	Homo sapiens	64-69
34817126-1	2021	OBJECTIVES: To evaluate the serum and salivary levels of IL-1beta, IL-6, IL-17A, TNF-alpha, IL-4 and, IL-10 in patients with Oral Lichen Planus (OLP) treated with Photobiomodulation (PBM) and clobetasol propionate 0.05%.	pbm	183-186	interleukin 1 alpha	Homo sapiens	57-65
34817126-1	2021	OBJECTIVES: To evaluate the serum and salivary levels of IL-1beta, IL-6, IL-17A, TNF-alpha, IL-4 and, IL-10 in patients with Oral Lichen Planus (OLP) treated with Photobiomodulation (PBM) and clobetasol propionate 0.05%.	Clobetasol	192-213	interleukin 1 alpha	Homo sapiens	57-65
34534743-3	2021	In treated chondrocytes, according to MTT assay and flow cytometry, gossypol increased viability and reduced apoptosis of IL-1beta induced chondrocytes.	Gossypol	68-76	interleukin 1 alpha	Homo sapiens	122-130
34534743-6	2021	Besides, overexpressed CX43 reversed the effects of gossypol on viability, apoptosis, and expressions of factors related to TLR4/MyD88/NF-kappaB pathway of IL-1beta-induced chondrocytes.	Gossypol	52-60	interleukin 1 alpha	Homo sapiens	156-164
34534743-7	2021	In conclusion, gossypol ameliorates IL-1beta-induced apoptosis and inflammation in chondrocytes by suppressing TLR4/MyD88/NF-kappaB pathway via downregulating CX43.	Gossypol	15-23	interleukin 1 alpha	Homo sapiens	36-44
34825387-0	2022	The effects of mannuronic acid on IL-1beta, IL-17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in multiple sclerosis.	mannuronic acid	15-30	interleukin 1 alpha	Homo sapiens	34-42
34813629-9	2021	Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome.	Ursodeoxycholic Acid	0-16	interleukin 1 alpha	Homo sapiens	162-170
34606909-4	2021	LPS induced-tissue damage promotes an elevation of extracellular ATP, triggering the NRLP3-inflammasome assembly and activation that, sequentially, induces caspase-1 cleavage and IL-1beta processing and secretion.	Adenosine Triphosphate	65-68	interleukin 1 alpha	Homo sapiens	179-187
34433098-9	2021	After K-3-rh intervention, the expression of Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta(IL-1beta), and nitric oxide(NO) in microglia were reduced contrast with those in the virus group, and the expression of interleukin-10(IL-10) did not change.	kaempferol 3-O-rhamnoside	6-12	interleukin 1 alpha	Homo sapiens	105-113
34795200-6	2021	Unfortunately, increases in matrix metalloproteinase 9, tumor necrosis factor alpha, and interleukin-1 were detected in the product after incubation; however, these increases could be blocked by adding citric acid, with no effect on the concentration of the target therapeutic molecules.	Citric Acid	202-213	interleukin 1 alpha	Homo sapiens	89-102
34824551-0	2021	lncRNA MCF2L-AS1/miR-105/ IL-1beta Axis Regulates Colorectal Cancer Cell Oxaliplatin Resistance.	Oxaliplatin	73-84	interleukin 1 alpha	Homo sapiens	26-34
34824551-6	2021	From a mechanistic perspective, miR-105 was identified as a MCF2L-AS1 target, with this miRNA, in turn, suppressing the expression of IL-1beta.	mir-105	32-39	interleukin 1 alpha	Homo sapiens	134-142
34824551-8	2021	Conclusion: The MCF2L-AS1/miR-105/IL-1beta regulatory axis regulates the resistance of CRC cells to OXA treatment.	2-phenyloxazolone	100-103	interleukin 1 alpha	Homo sapiens	34-42
34687817-8	2021	In vivo pharmacodynamic research showed that TP-Lipo@DMNs significantly reduced knee joint swelling and the level of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6).	tp-lipo@dmns	45-57	interleukin 1 alpha	Homo sapiens	152-160
34834886-13	2021	In addition, magnolol displayed inhibitory effects towards IL-1beta, IL-8 and TNF-alpha released from lipopolysaccharide (LPS)-stimulated human neutrophils, while honokiol only decreased IL-1beta secretion, compared to the untreated control.	magnolol	13-21	interleukin 1 alpha	Homo sapiens	59-67
34830395-5	2021	Using our method to measure ASC, stimulation of PBMC with lipopolysaccharide and nigericin or adenosine triphosphate resulted in microscopic identification of intracellular ASC specks, as well as interleukin 1 (IL-1) beta and caspase-1 p10 in the periphery.	Nigericin	81-90	interleukin 1 alpha	Homo sapiens	196-209
34830395-5	2021	Using our method to measure ASC, stimulation of PBMC with lipopolysaccharide and nigericin or adenosine triphosphate resulted in microscopic identification of intracellular ASC specks, as well as interleukin 1 (IL-1) beta and caspase-1 p10 in the periphery.	Nigericin	81-90	interleukin 1 alpha	Homo sapiens	211-221
34830395-5	2021	Using our method to measure ASC, stimulation of PBMC with lipopolysaccharide and nigericin or adenosine triphosphate resulted in microscopic identification of intracellular ASC specks, as well as interleukin 1 (IL-1) beta and caspase-1 p10 in the periphery.	Adenosine	94-103	interleukin 1 alpha	Homo sapiens	196-209
34830395-5	2021	Using our method to measure ASC, stimulation of PBMC with lipopolysaccharide and nigericin or adenosine triphosphate resulted in microscopic identification of intracellular ASC specks, as well as interleukin 1 (IL-1) beta and caspase-1 p10 in the periphery.	Adenosine	94-103	interleukin 1 alpha	Homo sapiens	211-221
34834886-13	2021	In addition, magnolol displayed inhibitory effects towards IL-1beta, IL-8 and TNF-alpha released from lipopolysaccharide (LPS)-stimulated human neutrophils, while honokiol only decreased IL-1beta secretion, compared to the untreated control.	magnolol	13-21	interleukin 1 alpha	Homo sapiens	187-195
34834886-13	2021	In addition, magnolol displayed inhibitory effects towards IL-1beta, IL-8 and TNF-alpha released from lipopolysaccharide (LPS)-stimulated human neutrophils, while honokiol only decreased IL-1beta secretion, compared to the untreated control.	honokiol	163-171	interleukin 1 alpha	Homo sapiens	187-195
34835109-5	2021	MPA treatment reduced the replication of both tested HIV-1 strains as well as the production of the mediators of inflammation IL-1beta, IL-17A and CCL5, but not CCL20, in a similar way to DEX, whereas P4 had no effect on HIV-1 replication.	Medroxyprogesterone Acetate	0-3	interleukin 1 alpha	Homo sapiens	126-134
34830316-2	2021	We have previously shown that DC contains both microbial components and calcium phosphate crystals that induce an osteoclastogenic cytokine IL-1beta via the NLRP3 inflammasome in macrophages.	calcium phosphate	72-89	interleukin 1 alpha	Homo sapiens	140-148
34867348-5	2021	In an epithelial cell culture model, RG0216 significantly decreased LPS-induced interleukin (IL)-6 and IL-1beta gene and protein expression and was as effective as equimolar concentrations of deprenyl (an existing irreversible MAO-B inhibitor).	rg0216	37-43	interleukin 1 alpha	Homo sapiens	103-111
34867348-7	2021	We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression.	Cyclic AMP	136-140	interleukin 1 alpha	Homo sapiens	93-101
34867348-7	2021	We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression.	Colforsin	153-162	interleukin 1 alpha	Homo sapiens	93-101
34867348-7	2021	We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression.	rg0216	173-179	interleukin 1 alpha	Homo sapiens	50-58
34867348-8	2021	Targeted protein kinase A (PKA) and Exchange Protein Activated by cAMP (EPAC) activation regulated IL-6 and IL-1beta expression, albeit in different ways, but both cytokines were effectively decreased with RG0216.	Cyclic AMP	66-70	interleukin 1 alpha	Homo sapiens	108-116
34867348-7	2021	We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression.	Cyclic AMP	63-67	interleukin 1 alpha	Homo sapiens	50-58
34867348-8	2021	Targeted protein kinase A (PKA) and Exchange Protein Activated by cAMP (EPAC) activation regulated IL-6 and IL-1beta expression, albeit in different ways, but both cytokines were effectively decreased with RG0216.	rg0216	206-212	interleukin 1 alpha	Homo sapiens	108-116
34824594-10	2021	ES dose-dependently (12.5, 25, and 50 mg/L) decreased the production and mRNA levels of proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Einsteinium	0-2	interleukin 1 alpha	Homo sapiens	114-122
34867421-5	2021	In this study, we therefore evaluated the effects of AM404 and acetaminophen on the arachidonic acid cascade and oxidative stress induced by interleukin (IL)-1beta in human SK-N-SH neuronal cells.	N-(4-hydroxyphenyl)arachidonylamide	53-58	interleukin 1 alpha	Homo sapiens	141-163
34867421-5	2021	In this study, we therefore evaluated the effects of AM404 and acetaminophen on the arachidonic acid cascade and oxidative stress induced by interleukin (IL)-1beta in human SK-N-SH neuronal cells.	Acetaminophen	63-76	interleukin 1 alpha	Homo sapiens	141-163
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	N-(4-hydroxyphenyl)arachidonylamide	17-22	interleukin 1 alpha	Homo sapiens	93-101
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	Acetaminophen	27-40	interleukin 1 alpha	Homo sapiens	93-101
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	Dinoprostone	121-125	interleukin 1 alpha	Homo sapiens	93-101
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Dinoprostone	34-38	interleukin 1 alpha	Homo sapiens	17-25
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Dinoprostone	34-38	interleukin 1 alpha	Homo sapiens	139-147
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	N-(4-hydroxyphenyl)arachidonylamide	50-55	interleukin 1 alpha	Homo sapiens	17-25
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	N-(4-hydroxyphenyl)arachidonylamide	50-55	interleukin 1 alpha	Homo sapiens	139-147
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Acetaminophen	60-73	interleukin 1 alpha	Homo sapiens	17-25
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Acetaminophen	60-73	interleukin 1 alpha	Homo sapiens	139-147
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	8-epi-prostaglandin F2alpha	109-124	interleukin 1 alpha	Homo sapiens	17-25
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	8-epi-prostaglandin F2alpha	109-124	interleukin 1 alpha	Homo sapiens	139-147
34831450-11	2021	Notably, inhibition of histone deacetylase (HDAC) activity by trichostatin A (TSA) resulted in the further elevation of IL-6 expression in response to combined treatment of adipocytes with IL-1beta and TNFalpha.	trichostatin A	62-76	interleukin 1 alpha	Homo sapiens	189-197
34831450-11	2021	Notably, inhibition of histone deacetylase (HDAC) activity by trichostatin A (TSA) resulted in the further elevation of IL-6 expression in response to combined treatment of adipocytes with IL-1beta and TNFalpha.	trichostatin A	78-81	interleukin 1 alpha	Homo sapiens	189-197
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	interleukin 1 alpha	Homo sapiens	177-195
34824594-12	2021	Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells.	Einsteinium	39-41	interleukin 1 alpha	Homo sapiens	168-176
34824594-12	2021	Conclusion: The results suggested that ES could selectively inhibit the activity of COX-2, and the anti-inflammatory effect of ES was associated with the inhibition of IL-1beta, IL-6, and TNF-alpha via negative regulation of MAPK and NF-kappaB signaling pathways in LPS-induced THP-1 cells.	Einsteinium	127-129	interleukin 1 alpha	Homo sapiens	168-176
34509913-5	2021	In parallel, HFO attenuated the expression of IL-1beta, IL-6 and TNF-alpha.	1,3,3,3-tetrafluoropropene	13-16	interleukin 1 alpha	Homo sapiens	46-54
34833991-12	2021	Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin.	Curcumin	145-153	interleukin 1 alpha	Homo sapiens	41-49
34858402-1	2021	Background: Interleukin (IL)-1 inhibitors represent the main treatment in patients with colchicine-resistant/intolerant familial Mediterranean fever (crFMF), mevalonate kinase deficiency (MKD), and tumor necrosis factor receptor-associated periodic syndrome (TRAPS).	Colchicine	88-98	interleukin 1 alpha	Homo sapiens	12-30
34827151-6	2021	Conditioned macrophages with serum obtained after four-week intervention with alcohol-free beer significantly reduced the transcription of pro-inflammatory interleukins such as IL-1beta and TNF.	Alcohols	78-85	interleukin 1 alpha	Homo sapiens	177-185
34867921-1	2021	Nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome-mediated interleukin-1 beta (IL-1beta) production is one of the crucial responses in innate immunity upon infection with viruses including influenza A virus (IAV) and is modulated by both viral and host cellular proteins.	Leucine	30-37	interleukin 1 alpha	Homo sapiens	121-129
34858390-4	2021	We now describe that the macrophage molecular clock, through Bmal1, regulates the uptake of glucose, its flux through glycolysis and the Krebs cycle, including the production of the metabolite succinate to drive Il-1beta production.	Glucose	92-99	interleukin 1 alpha	Homo sapiens	212-220
34858390-4	2021	We now describe that the macrophage molecular clock, through Bmal1, regulates the uptake of glucose, its flux through glycolysis and the Krebs cycle, including the production of the metabolite succinate to drive Il-1beta production.	krebs	137-142	interleukin 1 alpha	Homo sapiens	212-220
34749650-10	2021	N-acetyl-L-cysteine (NAC) reversed the DI effect on the LPS + ATP-induced macrophage pyroptosis and upregulated the IL-1beta expression.	Acetylcysteine	0-19	interleukin 1 alpha	Homo sapiens	116-124
34858390-4	2021	We now describe that the macrophage molecular clock, through Bmal1, regulates the uptake of glucose, its flux through glycolysis and the Krebs cycle, including the production of the metabolite succinate to drive Il-1beta production.	Succinic Acid	193-202	interleukin 1 alpha	Homo sapiens	212-220
34749650-10	2021	N-acetyl-L-cysteine (NAC) reversed the DI effect on the LPS + ATP-induced macrophage pyroptosis and upregulated the IL-1beta expression.	Acetylcysteine	21-24	interleukin 1 alpha	Homo sapiens	116-124
34749366-13	2021	miR-381-3p overexpression inhibited the release of IL-6, IL-1beta, and TNF-alpha induced by Abeta25-35 treatment, whereas miR-381-3p downregulation further promoted the release of inflammatory cytokines.	mir-381-3p	0-10	interleukin 1 alpha	Homo sapiens	57-65
34739306-5	2022	Simultaneously, they can reset the levels of pro-apoptotic proteins that belong to the Bcl-2 and caspase family and decrease the intracellular levels of ROS and pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6.	ros	153-156	interleukin 1 alpha	Homo sapiens	208-216
34739636-4	2022	Our results showed that the IL-1beta-stimulated production of inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were suppressed by GAA.	Nitric Oxide	95-107	interleukin 1 alpha	Homo sapiens	28-36
34739636-4	2022	Our results showed that the IL-1beta-stimulated production of inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were suppressed by GAA.	Dinoprostone	114-130	interleukin 1 alpha	Homo sapiens	28-36
34739636-4	2022	Our results showed that the IL-1beta-stimulated production of inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were suppressed by GAA.	Dinoprostone	132-136	interleukin 1 alpha	Homo sapiens	28-36
34732192-0	2021	Nicotine regulates autophagy of human periodontal ligament cells through alpha7 nAchR that promotes secretion of inflammatory factors IL-1beta and IL-8.	Nicotine	0-8	interleukin 1 alpha	Homo sapiens	134-142
34777694-3	2021	IL-1 secretion is the result of inflammasome activation which is besides apoptosis, a result of acute UVB treatment.	UVB	102-105	interleukin 1 alpha	Homo sapiens	0-4
34771080-0	2021	The Effect of Homocysteine on the Secretion of Il-1beta, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells-An In Vitro Study.	Homocysteine	14-26	interleukin 1 alpha	Homo sapiens	47-55
34771080-8	2021	Therefore, in our opinion, high-concentration homocysteine affects the progression of atherosclerosis by increasing the secretion of proinflammatory cytokines secreted by PBMNCs, such as Il-1beta, Il-6, RANTES, and by attenuating the secretion of Il-10.	Homocysteine	46-58	interleukin 1 alpha	Homo sapiens	187-195
34732192-7	2021	RT-qPCR and ELISA results revealed a noticeable rise in the release of inflammatory factors IL-1beta and IL-8 from hPDLCs in response to nicotine.	Nicotine	137-145	interleukin 1 alpha	Homo sapiens	92-100
34732192-8	2021	RT-qPCR and ELISA results showed that nicotine can significantly up-regulate the release of inflammatory factors IL-1beta and IL-8 in hPDLCs, and this effect can be inhibited by 3-MA (p < 0.05).	Nicotine	38-46	interleukin 1 alpha	Homo sapiens	113-121
34803718-12	2021	JZ-1 administration obviously ameliorates inflammatory responses with reduced T-lymphocytes, T helper cells, macrophages and neutrophils infiltration, and local IL-1beta, IL-6, TNF-alpha and CCL2 levels.	jz-1	0-4	interleukin 1 alpha	Homo sapiens	161-169
34769349-0	2021	High-Molecular-Weight Hyaluronic Acid Inhibits IL-1beta-Induced Synovial Inflammation and Macrophage Polarization through the GRP78-NF-kappaB Signaling Pathway.	Hyaluronic Acid	22-37	interleukin 1 alpha	Homo sapiens	47-55
34769349-8	2021	IL-1beta increased the expression of GRP78, NF-kappaB (p65 phosphorylation), IL-6, and PGE2 in primary synoviocytes, accompanied by an increased macrophage M1/M2 polarization.	Dinoprostone	87-91	interleukin 1 alpha	Homo sapiens	0-8
34510229-5	2021	Results revealed that CdCl2 (2-8 muM) increased ROS production and activated NLRP3, thereby enhancing secretion of IL-1beta and IL-18 (P < 0.05).	Cadmium Chloride	22-27	interleukin 1 alpha	Homo sapiens	115-123
34571395-7	2021	IL-1beta significantly increased in both un-stimulated and stimulated chlorhexidine 10 microM groups when compared to un-treated control (p < 0.05).	Chlorhexidine	70-83	interleukin 1 alpha	Homo sapiens	0-8
34571395-8	2021	MOI 100 chlorhexidine 10 microM group significantly increased IL-1beta compared to un-stimulated chlorhexidine 10 microM and epigallocatechin-gallate 10 microM groups, as well as to MOI 100 epigallocatechin-gallate 10 microM group (p < 0.05).	Chlorhexidine	8-21	interleukin 1 alpha	Homo sapiens	62-70
34571395-11	2021	S. mutans stimulation combined with chlorhexidine 100 microM treatment decreased cell viability, while treatment with chlorhexidine 10 microM concentration significantly increased IL-1beta.	Chlorhexidine	36-49	interleukin 1 alpha	Homo sapiens	180-188
34571395-11	2021	S. mutans stimulation combined with chlorhexidine 100 microM treatment decreased cell viability, while treatment with chlorhexidine 10 microM concentration significantly increased IL-1beta.	Chlorhexidine	118-131	interleukin 1 alpha	Homo sapiens	180-188
34510229-11	2021	Exposure to cadmium elevated serum levels of NLRP3 and IL-1beta in populations (P < 0.05).	Cadmium	12-19	interleukin 1 alpha	Homo sapiens	55-63
34510229-12	2021	Further analysis found that serum NLRP3 and IL-1beta levels were positively correlated with urine cadmium (UCd) and urine N-acetyl-beta-D-glucosaminidase (UNAG).	Cadmium	98-105	interleukin 1 alpha	Homo sapiens	44-52
34587513-6	2021	In addition, p38 mitogen-activated protein kinase (MAPK) activator dehydrocorydalmine chloride (Dc) also reversed the effect of RIP2 silencing on IL-1beta-induced chondrocytes.	dehydrocorydalmine chloride	67-94	interleukin 1 alpha	Homo sapiens	146-154
34628222-4	2021	In particular, corniculatolide B significantly inhibited the protein expression of COX-2 and the mRNA expressions of TNF-alpha, IL-1beta and IL-6 by inhibiting of NF-kappaB signaling in intestinal epithelial cells induced by lipopolysaccharide treatment.	corniculatolide b	15-32	interleukin 1 alpha	Homo sapiens	128-136
34481895-6	2021	We found IL-1beta treatment of primary human chondrocytes led to activation of NMDA receptors as evidenced by an increase in phosphorylation of GluN1 and an increase in intracellular calcium which was blocked by the NMDAR antagonist MK801.	Calcium	183-190	interleukin 1 alpha	Homo sapiens	9-17
34481895-6	2021	We found IL-1beta treatment of primary human chondrocytes led to activation of NMDA receptors as evidenced by an increase in phosphorylation of GluN1 and an increase in intracellular calcium which was blocked by the NMDAR antagonist MK801.	Dizocilpine Maleate	233-238	interleukin 1 alpha	Homo sapiens	9-17
34481895-7	2021	Levels of phosphorylated CREB were also elevated in IL-1beta treated cells and this effect was blocked by co-treatment of cells with IL-1beta and the NMDAR antagonist MK-801.	Dizocilpine Maleate	167-173	interleukin 1 alpha	Homo sapiens	52-60
34536574-13	2021	Additionally, circ_0001846 participated in IL-1beta-induced chondrocyte cell damage by sponging miR-149-5p.	mir-149-5p	96-106	interleukin 1 alpha	Homo sapiens	43-51
34587513-6	2021	In addition, p38 mitogen-activated protein kinase (MAPK) activator dehydrocorydalmine chloride (Dc) also reversed the effect of RIP2 silencing on IL-1beta-induced chondrocytes.	Deoxycytidine	96-98	interleukin 1 alpha	Homo sapiens	146-154
34310083-11	2021	Azithromycin concentration was positively correlated with IL-8 (r = 0.38, p = 0.03), IL1a (r = 0.39, p = 0.03), and IL-1b (r = 0.36, p = 0.04) in amniotic fluid.	Azithromycin	0-12	interleukin 1 alpha	Homo sapiens	85-89
34474149-8	2021	miR-148 inhibits IL-1beta expression in a dose-dependent manner at protein and mRNA levels.	mir-148	0-7	interleukin 1 alpha	Homo sapiens	17-25
34474149-9	2021	It is important that miR-148 participates in regulation of LPS-induced the NF-kappaB signaling pathway by inhibiting IL-1beta.	mir-148	21-28	interleukin 1 alpha	Homo sapiens	117-125
34539840-7	2021	LINC01385 knockdown and miR-140-3p mimics reduced the concentration of inflammatory factors in IL-1beta-induced HC-a and promoted cell survival.	mir-140-3p	24-34	interleukin 1 alpha	Homo sapiens	95-103
34539828-4	2021	ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10).	Thioctic Acid	0-3	interleukin 1 alpha	Homo sapiens	58-66
34539828-4	2021	ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10).	dihydrolipoic acid	4-8	interleukin 1 alpha	Homo sapiens	58-66
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	Isoflavones	42-52	interleukin 1 alpha	Homo sapiens	171-179
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	daidzein	75-83	interleukin 1 alpha	Homo sapiens	171-179
34630663-9	2021	The levels of TC, FC and CE and the mRNA levels of IL-1beta, IL-6, and TNF-alpha in the matrine group were lower than those in the model group, but higher than those in the normal group.	matrine	88-95	interleukin 1 alpha	Homo sapiens	51-59
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	Genistein	85-94	interleukin 1 alpha	Homo sapiens	171-179
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	glycitein	99-108	interleukin 1 alpha	Homo sapiens	171-179
34630655-7	2021	The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation.	daidzein	111-119	interleukin 1 alpha	Homo sapiens	171-179
34517275-12	2021	The results of the present study indicated that OMT inhibited the over-activation of microglia, increased the levels of the M2 marker IL-10, decreased the levels of the M1 markers NO, TNF-alpha, IL-6, and IL-1beta, promoted the polarization of N9 microglia to the M2 phenotype, and regulated M1/M2 polarization in the microglia by inhibiting TLR4/NF-kappaB signalling, which effectively attenuated the LPS-induced inflammatory response.	oxymatrine	48-51	interleukin 1 alpha	Homo sapiens	205-213
34535875-7	2021	Also, Agomelatine attenuated Abeta1-42 oligomers-induced inflammatory response by decreasing the expression of TNF-alpha and IL-1beta.	agomelatine	6-17	interleukin 1 alpha	Homo sapiens	125-133
34390919-10	2021	The peptide MTADV (but not scrambled TMVAD) significantly inhibited the release of pro-inflammatory cytokines IL-6 and IL-1beta from SAA-activated human fibroblasts, THP-1 monocytes and peripheral blood mononuclear cells.	mtadv	12-17	interleukin 1 alpha	Homo sapiens	119-127
34509368-3	2021	Results of enzyme-linked immunosorbent assay (ELISA) showed that WEKPPVSH significantly mitigated the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) (P < 0.01).	wekppvsh	65-73	interleukin 1 alpha	Homo sapiens	175-183
34296780-11	2021	RESULTS: SMSC-EVs enhanced IL-1beta-induced SW1353 cell proliferation while inhibited apoptosis and inflammation.	smsc-evs	9-17	interleukin 1 alpha	Homo sapiens	27-35
34107088-1	2021	Retraction: "Ligustrazine protects chondrocyte against IL-1beta induced injury by regulation of SOX9/NF-kappaB signaling pathway," by Tao Yu, Ji Qu, Yang Wang, Hui Jin, J Cell Biochem.	tetramethylpyrazine	13-25	interleukin 1 alpha	Homo sapiens	55-63
34554188-6	2021	As NLRP3 tyrosine modification by BTK also positively regulates IL-1beta release, we propose BTK as a multifunctional positive regulator of NLRP3 regulation and BTK phosphorylation of NLRP3 as a novel and therapeutically tractable step in the control of inflammation.	Tyrosine	9-17	interleukin 1 alpha	Homo sapiens	64-72
34296780-13	2021	Downregulation of miR-26a-5p in EVs attenuated the protection of EVs against IL-1beta-induced cell damage.	mir-26a-5p	18-28	interleukin 1 alpha	Homo sapiens	77-85
34296780-14	2021	miR-26a-5p targeted PTEN, whose overexpression spoiled the protection of EVs against IL-1beta-induced cell damage.	mir-26a-5p	0-10	interleukin 1 alpha	Homo sapiens	85-93
34628106-5	2021	In human placental tissue culture, treatment with BHB suppressed the secretion levels of inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and IL-8, but did not affect the mRNA expression levels of NLRP3 inflammasome-associated factors.	3-Hydroxybutyric Acid	50-53	interleukin 1 alpha	Homo sapiens	121-143
34772757-7	2021	RESULTS: In this work, we use an IL-1beta-based AcTakine to drive proliferation and effector functionality of antitumor CD8+ T cells without inducing measurable toxicity.	actakine	48-56	interleukin 1 alpha	Homo sapiens	33-41
34772757-11	2021	CONCLUSIONS: Our data illustrate that anticancer cellular immunity can be safely promoted with an IL-1beta-based AcTakine, which synergizes with other immunotherapies for efficient tumor destruction.	actakine	113-121	interleukin 1 alpha	Homo sapiens	98-106
34628106-6	2021	Treatment with BHB reduced IL-1beta secretion and the amount of mature IL-1beta protein induced by lipopolysaccharide (LPS) stimulation in the placenta.	3-Hydroxybutyric Acid	15-18	interleukin 1 alpha	Homo sapiens	27-35
34628106-6	2021	Treatment with BHB reduced IL-1beta secretion and the amount of mature IL-1beta protein induced by lipopolysaccharide (LPS) stimulation in the placenta.	3-Hydroxybutyric Acid	15-18	interleukin 1 alpha	Homo sapiens	71-79
34628106-7	2021	In human trophoblast cells, BHB reduced ASC and activated-caspase-1 expression, resulting in the inhibition of IL-1beta secretion.	3-Hydroxybutyric Acid	28-31	interleukin 1 alpha	Homo sapiens	111-119
34186308-6	2021	Liver IL-6, IL-1beta and hepcidin expression were significantly increased following LCHS/CS-14.	Cesium	89-91	interleukin 1 alpha	Homo sapiens	12-20
34288018-3	2021	Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), beta3-integrin, or RANKL, toll-like receptors and growth factor receptors.	Artemisinins	62-74	interleukin 1 alpha	Homo sapiens	104-117
34288018-3	2021	Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), beta3-integrin, or RANKL, toll-like receptors and growth factor receptors.	Artemisinins	62-74	interleukin 1 alpha	Homo sapiens	119-123
34146182-3	2021	Our study aimed to explore the function of higenamine on interleukin (IL)-1beta-caused apoptosis of human nucleus pulposus cells (HNPCs).	higenamine	43-53	interleukin 1 alpha	Homo sapiens	57-79
34146182-7	2021	We found that higenamine showed little effect on cell apoptosis, but mitigated IL-1beta-caused apoptosis in a dose-dependent pattern.	higenamine	14-24	interleukin 1 alpha	Homo sapiens	79-87
34146182-8	2021	Higenamine attenuated IL-1beta-induced decrease of Bcl-2 and increase of Bax and cleaved caspase-3.	higenamine	0-10	interleukin 1 alpha	Homo sapiens	22-30
34146182-9	2021	Higenamine did not affect the reactive oxygen species (ROS) level and the PI3K/Akt signaling, but attenuated IL-1beta-induced ROS production and inhibition of the PI3K/Akt signaling.	higenamine	0-10	interleukin 1 alpha	Homo sapiens	109-117
34146182-9	2021	Higenamine did not affect the reactive oxygen species (ROS) level and the PI3K/Akt signaling, but attenuated IL-1beta-induced ROS production and inhibition of the PI3K/Akt signaling.	Reactive Oxygen Species	126-129	interleukin 1 alpha	Homo sapiens	109-117
34146182-11	2021	The PI3K/Akt signaling suppression using LY294002 reversed the inhibitive effect of higenamine on IL-1beta-caused apoptosis, and this effect was weakened by ROS inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interleukin 1 alpha	Homo sapiens	98-106
34146182-11	2021	The PI3K/Akt signaling suppression using LY294002 reversed the inhibitive effect of higenamine on IL-1beta-caused apoptosis, and this effect was weakened by ROS inhibition.	higenamine	84-94	interleukin 1 alpha	Homo sapiens	98-106
34146182-11	2021	The PI3K/Akt signaling suppression using LY294002 reversed the inhibitive effect of higenamine on IL-1beta-caused apoptosis, and this effect was weakened by ROS inhibition.	Reactive Oxygen Species	157-160	interleukin 1 alpha	Homo sapiens	98-106
34146182-12	2021	In conclusion, higenamine attenuates IL-1beta-caused apoptosis of HNPCs via ROS-mediated PI3K/Akt pathway.	higenamine	15-25	interleukin 1 alpha	Homo sapiens	37-45
34515319-11	2021	Moreover, forkhead box O4 (FOXO4) was found to be the direct target of miR-1184, and exosomes expressing miR-1184 notably inhibited cisplatin-induced inflammatory responses in HK-2 cells via the mediation of IL-1beta and TNF-alpha.	Cisplatin	132-141	interleukin 1 alpha	Homo sapiens	208-216
34536551-4	2021	Nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome, whose activation and assembly significantly affect the release of IL-1beta, is a crucial effector activated by a variety of metabolites.	Leucine	46-53	interleukin 1 alpha	Homo sapiens	169-177
34612061-6	2021	GSEA identified hundreds of pathways that varied between culture methods, such as IL1 cytokine signaling enriched in transwell vs. monolayer cultures, and E2F target genes enriched in collagen vs. Matrigel cultures.	gsea	0-4	interleukin 1 alpha	Homo sapiens	82-85
34106437-5	2021	Progesterone stimulation decreased the expression of TLR2, TLR5, and Nod2 genes (alone and/or in combination with TLR/NLR agonists) and decreased the expression of IL-1beta and IL-8 genes increased by stimulation with specific agonists for TLR2, TLR4, TLR5, Nod1, and Nod2.	Progesterone	0-12	interleukin 1 alpha	Homo sapiens	164-172
34757278-8	2021	Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation.	Oxygen	145-151	interleukin 1 alpha	Homo sapiens	78-82
34764759-7	2021	Furthermore, the findings revealed that 4-HI also improved the levels of other neurotransmitters (Ach, DOPA, GABA, glutamate); inflammatory cytokines (TNF-alpha, IL-1beta, IL-17), and oxidative stress markers (MDA, nitrite, LDH, AchE, SOD, CAT, GPx, GSH) in the brain when evaluated after Day 35.	4-hydroxyisoleucine	40-44	interleukin 1 alpha	Homo sapiens	162-170
34819793-13	2021	There was also a statistically significant difference between DHA group 22(73.3), 95% CI (55.9, 86.5) and the control group 8 (26.7), 95% CI (13.5, 44.1) in the percentage change in IL-1beta levels (p = 0.0001).A statistically significant association was found between IL and 1 beta change and NEC diagnosis (p = 0.001).	Docosahexaenoic Acids	62-65	interleukin 1 alpha	Homo sapiens	182-190
34245174-11	2021	IL1A genetic polymorphisms were the potential biomarkers for OHRQoL in Para athletes.	ohrqol	61-67	interleukin 1 alpha	Homo sapiens	0-4
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	interleukin 1 alpha	Homo sapiens	163-171
34672136-7	2021	RESULTS: U937 cells treated with CpG-ODN induced activation of the NF-kappaB pathway and increased the expression of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, but reduced that of IL-37.	CPG-oligonucleotide	33-40	interleukin 1 alpha	Homo sapiens	148-156
34672136-9	2021	Human macrophages transfected with IL-37 siRNA augmented the expression of IL-1beta, TNF-alpha, and IL-6 mRNA and protein in cells treated with CpG-ODN.	CPG-oligonucleotide	144-151	interleukin 1 alpha	Homo sapiens	75-83
34754326-6	2021	DMF treatment significantly decreased the accumulation of ROS, downregulated inflammatory cytokines (p-NF-kappaB, IL-1beta, and TNF-alpha), and ER stress-associated apoptosis proteins (Bip, calpain-1, caspase-12, caspase-3, and Bax) in LPS-challenged NPCs.	Dimethyl Fumarate	0-3	interleukin 1 alpha	Homo sapiens	114-122
34770980-5	2021	Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)).	Polyphenols	0-11	interleukin 1 alpha	Homo sapiens	160-171
34778254-8	2021	The PCL-DEX electrode has great potential in preventing hearing loss and fibrosis by regulating macrophages and inhibiting the expression of the fibrosis-related factors IL-1beta, TNF-alpha, IL-4, and TGF-beta1.	pcl-dex	4-11	interleukin 1 alpha	Homo sapiens	170-178
34528913-4	2021	The elevation of IL-1beta and IL-6 concentrations in synovial fluid following OA induction were dose-dependently (P < 0.05) reduced by LMCP treatment.	lmcp	135-139	interleukin 1 alpha	Homo sapiens	17-25
34708887-7	2022	However, administration of NOX1/4 inhibitor GKT137831 alleviated PM2.5 -induced elevated endothelial dysfunction biomarkers (NO, ET-1, ADMA, iNOS, and tPA/PAI-1), inflammatory factors (IL-1beta, IL-10, and IL-18), and adhesion molecules (ICAM-1, VCAM-1, and P-selectin) and also passivated NOX-dependent AKT and eNOS phosphorylation that involved in endothelial activation.	setanaxib	44-53	interleukin 1 alpha	Homo sapiens	185-193
34689174-5	2021	In particular, the activated endothelium releases reactive oxygen species and interleukin (IL)-6 which in turn stimulate transformation of monocytes to become antigen presenting cells and produce cytokines like IL-1beta and IL-23, which further affect T cell function to produce IL-17A.	Reactive Oxygen Species	50-73	interleukin 1 alpha	Homo sapiens	211-219
34695410-7	2022	UV exposure increased OGG1, iNOS and IL-1beta expression, an effect counteracted by NAM pre-treatment.	Niacinamide	84-87	interleukin 1 alpha	Homo sapiens	37-45
34686215-5	2021	Further results showed that famotidine triggered cell pyroptosis in gastric cancer cells by activation of NLPR3 inflammasomes including ASC, Caspase-1 and NLRP, leading to enhanced IL-18, not IL-1beta, mature and secretion.	Famotidine	28-38	interleukin 1 alpha	Homo sapiens	192-200
34768828-2	2021	Nucleotide-binding oligomerization domain (NOD)-Leucine-rich repeats (LRR)-containing receptors (NLRs), also called nucleotide-binding oligomerization (NOD)-like receptors (NLRs), are major cytosolic pattern recognition receptors (PRRs), their involvement in the orchestration of innate immunity and host defense against bacteria, viruses, fungi and parasites, often results in the cleavage of gasdermin and the release of IL-1beta and IL-18, should be tightly regulated.	Leucine	48-55	interleukin 1 alpha	Homo sapiens	423-431
34769627-7	2021	Naive THP-1 cells produced significantly elevated levels of IL-1beta, IL-8, and TNF-alpha when exposed to ethyl maltol and hexanal.	ethyl maltol	106-118	interleukin 1 alpha	Homo sapiens	60-68
34769627-7	2021	Naive THP-1 cells produced significantly elevated levels of IL-1beta, IL-8, and TNF-alpha when exposed to ethyl maltol and hexanal.	n-hexanal	123-130	interleukin 1 alpha	Homo sapiens	60-68
34769627-8	2021	Activated THP-1 cells released increased IL-1beta and TNF-alpha when exposed to ethyl maltol, but many flavoring chemicals had an apparent suppressive effect on inflammatory cytokines released by activated macrophages, some with varying degrees of accompanying cytotoxicity.	ethyl maltol	80-92	interleukin 1 alpha	Homo sapiens	41-49
34831052-3	2021	One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis.	Cholesterol	107-118	interleukin 1 alpha	Homo sapiens	150-154
34831052-3	2021	One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis.	Uric Acid	120-125	interleukin 1 alpha	Homo sapiens	150-154
34831052-3	2021	One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis.	Glucose	131-138	interleukin 1 alpha	Homo sapiens	150-154
34745125-3	2021	Furthermore, the NLRP3 agonists H2O2 and MSU elicited IL-1beta maturation without inducing specks.	Hydrogen Peroxide	32-36	interleukin 1 alpha	Homo sapiens	54-62
34822668-5	2021	The generation of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumour necrosis factor alpha, is induced by 1-NP in a concentration-dependent manner in macrophages.	1-nitropyrene	131-135	interleukin 1 alpha	Homo sapiens	53-75
34727650-6	2021	Results: Compared with the control group and DMSO group, the expression levels of IL-1beta, IL-6, TNF-alpha in alveolar macrophages decreased significantly in the ATL-I group (P<0.05) , and the expression levels of p-NF-kappaB, the ratio of LC3-II/LC3-I also decreased significantly in the ATL-I group (P<0.05) .	Dimethyl Sulfoxide	45-49	interleukin 1 alpha	Homo sapiens	82-90
34755662-9	2021	SX treatment (20 and 40 mg/L) and TGT treatment both significantly lowered the expression levels of TNF-alpha, IL-1beta, and IL-18 in the cells (P < 0.05).	sx	0-2	interleukin 1 alpha	Homo sapiens	111-119
34680177-5	2021	NMP at concentrations as low as 1 micromol/L reduced the stimulated expression of several pro-inflammatory mediators, including C-C Motif chemokine ligand (CCL)-2, C-X-C Motif chemokine ligand (CXCL)-10, and intercellular adhesion Molecule (ICAM)-1, but left the induction of prostaglandin G/H synthase (PTGS)2, interleukin (IL)-1beta, and colony stimulating factor (CSF)1 unaffected.	1-methylpyridinium	0-3	interleukin 1 alpha	Homo sapiens	312-334
34733807-8	2021	The univariate analysis showed that there were significant differences between the PB group and the non-PB group in LDH, D-dimer, CD3+CD4+(%), CD3+CD4+/CD3+CD8+, CD3 count, CD4 count, CD8 count, complement 3, IL8, IL-1beta, IL-2, IL-10 (P < 0.05).	pladienolide B	83-85	interleukin 1 alpha	Homo sapiens	214-222
34681847-4	2021	In the cell model, linagliptin attenuated ROS by activating the AMP-activated protein kinase (AMPK) pathway, restoring nuclear-factor-erythroid-2-related factor (Nrf2) and heme oxygenase 1 (HO-1) protein, and decreasing pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta)).	Linagliptin	19-30	interleukin 1 alpha	Homo sapiens	312-320
34657549-5	2021	The release of IL-1beta was suppressed by disulfiram, an FDA-approved drug known to act as an inhibitor of membrane pore formation by GSDMD.	Disulfiram	42-52	interleukin 1 alpha	Homo sapiens	15-23
34786083-10	2021	Additionally, circulating levels of IL-1beta and MCP-1 could serve as promising prognostic markers for patients with paraquat poisoning.	Paraquat	117-125	interleukin 1 alpha	Homo sapiens	36-44
34182399-6	2021	Additionally, the caspase-1/IL-1beta axis is involved in inflammatory responses but not cell pyroptosis in EA.hy926 cells following the exposure to PM SRM1648a.	srm1648a	151-159	interleukin 1 alpha	Homo sapiens	28-36
34425162-4	2021	Pretreatment of HNE cells with the specific vacuolar H+-ATPase inhibitor bafilomycin A1 reduced the RV-C03 RNA levels in the ASL; inflammatory cytokines, including interleukin (IL)-1beta, IL-6 and IL-8, in the supernatant; the mRNA expression of the RV-C receptor cadherin-related family member 3 (CDHR3) in the cells; and the number of acidic endosomes where RV-B RNA enters the cytoplasm.	bafilomycin A1	73-87	interleukin 1 alpha	Homo sapiens	164-186
34681768-7	2021	BAY-117082 at higher concentrations significantly reduced NLRP3, ASC, caspase-1, IL-1beta, and IL-18 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-10	interleukin 1 alpha	Homo sapiens	81-89
34649564-9	2021	Noticeably, overexpressing circ_0045714 and inhibiting miR-331-3p could suppress IL-1beta-evoked these effects, and both were through up-regulating PIK3R3, a key gene in PI3K/AKT signaling pathway.	mir-331-3p	55-65	interleukin 1 alpha	Homo sapiens	81-89
34665696-11	2021	CONCLUSIONS: These findings are consistent with known signalling pathways employed by OSM, TNFalpha and IL-1beta, but our data suggest that in HSF, baricitinib may have anti-inflammatory effects via downstream modulation of cytokines and chemokines produced in response to TNFalpha or IL-1beta.	baricitinib	148-159	interleukin 1 alpha	Homo sapiens	285-293
34684771-9	2021	EAS also markedly suppressed the S1-induced transcription of IL-6 and IL-1beta.	CHEMBL4167713	0-3	interleukin 1 alpha	Homo sapiens	70-78
34684771-12	2021	Attenuation of S1-induced transcription of IL-6 and IL-1beta by the MAPK kinase inhibitor U0126 was greater than that by the Akt inhibitor perifosine, and the effects were potentiated by simultaneous treatment with both inhibitors.	U 0126	90-95	interleukin 1 alpha	Homo sapiens	52-60
34684771-13	2021	These results suggest that EAS attenuates S1-induced IL-6 and IL-1beta production by suppressing p44/42 MAPK and Akt signaling in macrophages.	CHEMBL4167713	27-30	interleukin 1 alpha	Homo sapiens	62-70
34665696-9	2021	Although both TNFalpha and IL-1beta signal independently of the JAK/STAT pathway, in HSF, but not in RA FLS, baricitinib significantly inhibited TNFalpha- and IL-1beta-induced MCP-1 and IP-10 protein levels in a dose dependent manner.	baricitinib	109-120	interleukin 1 alpha	Homo sapiens	27-35
34665696-9	2021	Although both TNFalpha and IL-1beta signal independently of the JAK/STAT pathway, in HSF, but not in RA FLS, baricitinib significantly inhibited TNFalpha- and IL-1beta-induced MCP-1 and IP-10 protein levels in a dose dependent manner.	baricitinib	109-120	interleukin 1 alpha	Homo sapiens	159-167
34712133-9	2021	Concurrently, DIZE-inhibited oxidative stress and nitrosative stress via p38MAPK and NF-kappaB pathways consequently reduced release of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta.	diminazene aceturate	14-18	interleukin 1 alpha	Homo sapiens	192-200
34614009-8	2021	Additionally, treatment with C3G resulted in a significant reduction in the protein expression of inflammatory markers IL-1beta and NLRP3 (p<0.01) as well as an increase in LC3 autophagic marker (p<0.05) in human islets treated with amylin, Abeta1-42, rapamycin, or H2O2.	Hydrogen Peroxide	266-270	interleukin 1 alpha	Homo sapiens	119-127
34147605-5	2021	In our study, RAW264.7 macrophages were treated with different concentrations of BPF (0, 5, 10 and 20 muM) for 24 h. The results showed that the secretion of pro-inflammatory cytokines (IL-6, TNF-alpha and IL-1beta) and the production of lactate were increased in a dose-dependent manner.	bisphenol F	81-84	interleukin 1 alpha	Homo sapiens	206-214
34627370-13	2021	Non-treated MenSCs decreased the frequency of Tregs, whereas after pre-treatment with IFN-gamma and IL-1beta, they induced functional Tregs with ability to inhibit the proliferation of anti-CD3/CD28-stimulated PBMCs.	tregs	134-139	interleukin 1 alpha	Homo sapiens	100-108
34627370-16	2021	CONCLUSION: Collectively, these findings indicate that immunomodulatory impact of menstrual blood stem cells (MenSCs) on generation of Tregs and inhibition of T cells proliferation is largely dependent on pre-treatment with IFN-gamma and IL-1beta.	tregs	135-140	interleukin 1 alpha	Homo sapiens	238-246
34691015-12	2021	Lactate significantly reduced the concentrations of TNF and IL-1beta produced by human macrophages in response to Mtb but did not alter IL-10 and IL-6 production.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	60-68
34599154-7	2021	Consistently, miR-138-5p inhibition reversed the effects of lncRNA NLRP3 silencing on the expression of NLRP3-related molecules and inhibition of the NLRP3/caspase-1/IL-1beta signalling pathway.	mir-138-5p	14-24	interleukin 1 alpha	Homo sapiens	166-174
34608940-12	2022	Moreover, positive correlations were observed between the serum levels of IL-1beta, IL-6, and urinary 1-OH-P levels in bitumen fumes-exposed workers, respectively (P < 0.05).	Oxaliplatin	102-108	interleukin 1 alpha	Homo sapiens	74-82
34608940-15	2022	The serum levels of IL-1beta and IL-6 were positive correlated with the urinary 1-OH-P levels in bitumen fumes exposed workers.	Oxaliplatin	80-86	interleukin 1 alpha	Homo sapiens	20-28
34303665-1	2021	The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in a combination of inflammatory diseases.	Resveratrol	114-125	interleukin 1 alpha	Homo sapiens	188-206
34148304-6	2021	Additionally, ginkgetin suppressed HG-evoked transcript and release of inflammatory cytokine TNF-alpha, IL-1beta and IL-6.	ginkgetin	14-23	interleukin 1 alpha	Homo sapiens	104-112
34596979-3	2021	In this study, we compared the binding of four inflammatory cytokines (CCL8, IL-1beta, IL-2 and IL-6) to immobilized heparin by an SPR analysis.	Heparin	117-124	interleukin 1 alpha	Homo sapiens	77-85
34514543-10	2021	Conversely, alpha7 nAChR-specific agonist GTS-21 diminished the release of interleukin-1beta (IL-1beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNFalpha) in SH-SY5Y cells under inflammatory conditions.	3-(2,4-dimethoxybenzylidene)anabaseine	42-48	interleukin 1 alpha	Homo sapiens	94-102
34688464-5	2021	The results suggested that Neo decreased the levels of interleukin IL-1beta, IL-6, IL-8, TNF-alpha, MMP-3, MMP-9 and MMP-13 in FLSs.	neohesperidin	27-30	interleukin 1 alpha	Homo sapiens	67-75
34098069-5	2021	Elevated ROS and NLRP3, caspase-1, IL-1beta and IL-18 were detected, which was attenuated by N-acetylcysteine.	Acetylcysteine	93-109	interleukin 1 alpha	Homo sapiens	35-43
34547129-4	2021	Based on this, we established a transcriptional and proteomic signature of macrophages stimulated by itaconate and identified the pathways of IL-1beta secretion and altered iron metabolism.	itaconic acid	101-110	interleukin 1 alpha	Homo sapiens	142-150
34547129-7	2021	Only cysteine and antioxidants (catechin hydrate) could inhibit caspase-1 activation and IL-1beta secretion in itaconate-stimulated macrophages.	Cysteine	5-13	interleukin 1 alpha	Homo sapiens	89-97
34547129-7	2021	Only cysteine and antioxidants (catechin hydrate) could inhibit caspase-1 activation and IL-1beta secretion in itaconate-stimulated macrophages.	(+)-Catechin Hydrate	32-48	interleukin 1 alpha	Homo sapiens	89-97
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Tricarboxylic Acids	104-122	interleukin 1 alpha	Homo sapiens	198-206
34547129-9	2021	Our results demonstrate the counteracting effects of overexpression of mitochondrial aconitase (ACO2, a tricarboxylic acid cycle enzyme) or cytosolic aconitase (ACO1, an iron regulatory protein) on IL-1beta secretion and altered iron metabolism.	Iron	170-174	interleukin 1 alpha	Homo sapiens	198-206
34378862-17	2021	CONCLUSIONS: Application of chlorhexidine gel reduced inflammation and IL1-beta levels in the peri-implant soft tissue.	Chlorhexidine	28-41	interleukin 1 alpha	Homo sapiens	71-79
34332276-7	2021	In addition, SP significantly increased TNF-alpha, IL-1beta, IL-6, ICAM-1, VCAM-1, P-selectin, and E-selectin levels (P < 0.01), decreased IL-10 levels (P < 0.01), and increased the adhesion rates of monocytes and neutrophils (P < 0.01).	Palmitic Acid	13-15	interleukin 1 alpha	Homo sapiens	51-59
34447474-3	2021	However, the potential effect of HM on the production of interleukin-1beta (IL-1beta), the main immunoregulatory cytokine secreted by activated monocytes, has not been reported.	His-Met	33-35	interleukin 1 alpha	Homo sapiens	76-84
34447474-5	2021	Signaling pathways involved in the HM-induced IL-1beta production was investigated in the THP-1 cells.	His-Met	35-37	interleukin 1 alpha	Homo sapiens	46-54
34447474-8	2021	The blockade of the p38 MAPK pathway, with the pharmacological inhibitor SB202190, and TLR2 receptor with a neutralization antibody, resulted in the decrease of HM-induced IL-1beta production in THP-1 cells.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	73-81	interleukin 1 alpha	Homo sapiens	172-180
34447474-8	2021	The blockade of the p38 MAPK pathway, with the pharmacological inhibitor SB202190, and TLR2 receptor with a neutralization antibody, resulted in the decrease of HM-induced IL-1beta production in THP-1 cells.	His-Met	161-163	interleukin 1 alpha	Homo sapiens	172-180
34447474-9	2021	The TLR4 receptor blockade also decreased HM-induced IL-1beta production, but to a lesser extent than TLR2 blockade.	His-Met	42-44	interleukin 1 alpha	Homo sapiens	53-61
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	38-46
34229177-8	2021	Moreover, the ELISA results revealed that licochalcone E significantly reduced the expression of TNF-alpha, IL-1beta, and IL-18.	licochalcone E	42-56	interleukin 1 alpha	Homo sapiens	108-116
34229177-10	2021	Western blot results further indicated that licochalcone E significantly reduced the expression of NLRP3, caspase-1 and IL-1beta in the model.	licochalcone E	44-58	interleukin 1 alpha	Homo sapiens	120-128
34640589-8	2021	Significant correlations were found between FeNO 50 mL/s and IL-17, IL-1 and VEGF.	flubendiamide	44-48	interleukin 1 alpha	Homo sapiens	68-72
34368883-10	2021	Concurrently, oxymatrine inhibited ox-LDL-induced NLRP3 inflammasome-mediated pyroptosis in HUVECs, as evidenced by the significant decreases in the expression of NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), cleaved caspase-1, interleukin (IL)-1beta and IL-18 in HUVECs.	oxymatrine	14-24	interleukin 1 alpha	Homo sapiens	287-309
34274310-0	2021	Potential of ephedrine to suppress the gene expression of TNF-alpha, IL-1beta, IL-6 and PGE2: A novel approach towards management of rheumatoid arthritis.	Ephedrine	13-22	interleukin 1 alpha	Homo sapiens	69-77
34402957-4	2021	Long-term exposure to high glucose significantly enhanced the increase in the production of pro-inflammatory cytokines, including tumor necrosis-alpha, interleukin (IL)-1beta, and IL-6, when macrophages were stimulated with LPS.	Glucose	27-34	interleukin 1 alpha	Homo sapiens	152-174
34250720-9	2021	What is more, hypaphorine attenuated the expression of inflammatory factors (IL-1beta, IL-6, TNF-alpha, and IL-18) and inactivated the p38/JNK signaling pathway through upregulating DUSP1 in a dose-dependent manner.	lenticin	14-25	interleukin 1 alpha	Homo sapiens	77-85
34435647-7	2021	CT treatment also reduced the increase in the mRNA levels of IL-6, IL-1beta and TNF-alpha induced by CoCl2.	cobaltous chloride	101-106	interleukin 1 alpha	Homo sapiens	67-75
34293392-13	2021	BA applications were more effective than BX on U-87MG cell line in terms of increasing MDA levels, SOD and CAT enzyme activities, and decreasing Interleukin-1alpha, Interleukin-6 and Tumor necrosis factor- alpha (TNF- alpha) levels.	boric acid	0-2	interleukin 1 alpha	Homo sapiens	145-163
34686461-12	2022	Colchicine patients had numerically lower levels of pre-PCI cytokines: IL-1beta (p = 0.01), IL-6 (p = 0.02), IL-10 (p = 0.01), IFNgamma (p = 0.01), TNFalpha (p = 0.02) and WBC-count (p = 0.04).	Colchicine	0-10	interleukin 1 alpha	Homo sapiens	71-79
34216363-11	2021	Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone.	Propofol	143-151	interleukin 1 alpha	Homo sapiens	60-68
34216363-11	2021	Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone.	Benzbromarone	182-195	interleukin 1 alpha	Homo sapiens	60-68
34390063-5	2021	Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression.	Curcumin	85-93	interleukin 1 alpha	Homo sapiens	148-156
34390063-5	2021	Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression.	Resveratrol	95-106	interleukin 1 alpha	Homo sapiens	148-156
34390063-5	2021	Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression.	Quercetin	112-121	interleukin 1 alpha	Homo sapiens	148-156
34861913-3	2021	Flares of cold-induced urticaria might depend on the release of histamine and other pro-inflammatory mediators, such as Interleukin (IL)-1, which is the predominating stakeholder of cryopyrin-associated periodic syndrome, a genetic disease characterized by cold-induced skin manifestations, including urticaria-like rashes.	Histamine	64-73	interleukin 1 alpha	Homo sapiens	120-138
34664816-10	2021	However, non-significant variations in the IL-1beta and IL-17 levels suggest an alternative way of NAC effectiveness without influencing the measured cytokines.	Acetylcysteine	99-102	interleukin 1 alpha	Homo sapiens	43-51
34302591-0	2021	Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-alpha, IL-6, IL-1beta, and COX-2.	Venlafaxine Hydrochloride	0-11	interleukin 1 alpha	Homo sapiens	102-110
34302591-9	2021	Upon PCR analysis venlafaxine remarkably turndown the mRNA expression of TNF-alpha, IL-6, IL-1beta, and COX-2.	Venlafaxine Hydrochloride	18-29	interleukin 1 alpha	Homo sapiens	90-98
34680642-5	2021	Moreover, the mRNA and protein expression levels of the inflammatory cytokines TNFalpha, IL-6, IL-1beta, and IFNgamma were increased by LPS, but were significantly reduced by AE-GBE treatment.	ae-gbe	175-181	interleukin 1 alpha	Homo sapiens	95-103
34680443-3	2021	Here, we evaluated the effect of PBUTs on inflammasome-mediated IL-1beta production in vitro and in vivo.	pbuts	33-38	interleukin 1 alpha	Homo sapiens	64-72
34638670-12	2021	Significant increases in plasma and kidney IL-1beta and IL-18 in response to CLP were decreased with Clopidogrel treatment.	Clopidogrel	101-112	interleukin 1 alpha	Homo sapiens	43-51
34680443-4	2021	Exposure of human conditionally immortalized proximal tubule epithelial cells to indoxyl sulfate (IS) and a mixture of anionic PBUTs (UT mix) increased expression levels of NLRP3, caspase-1 and IL-1beta, accompanied by a significant increase in IL-1beta secretion and caspase-1 activity.	Indican	81-96	interleukin 1 alpha	Homo sapiens	194-202
34680443-4	2021	Exposure of human conditionally immortalized proximal tubule epithelial cells to indoxyl sulfate (IS) and a mixture of anionic PBUTs (UT mix) increased expression levels of NLRP3, caspase-1 and IL-1beta, accompanied by a significant increase in IL-1beta secretion and caspase-1 activity.	Indican	81-96	interleukin 1 alpha	Homo sapiens	245-253
34680443-4	2021	Exposure of human conditionally immortalized proximal tubule epithelial cells to indoxyl sulfate (IS) and a mixture of anionic PBUTs (UT mix) increased expression levels of NLRP3, caspase-1 and IL-1beta, accompanied by a significant increase in IL-1beta secretion and caspase-1 activity.	Indican	98-100	interleukin 1 alpha	Homo sapiens	194-202
34680443-4	2021	Exposure of human conditionally immortalized proximal tubule epithelial cells to indoxyl sulfate (IS) and a mixture of anionic PBUTs (UT mix) increased expression levels of NLRP3, caspase-1 and IL-1beta, accompanied by a significant increase in IL-1beta secretion and caspase-1 activity.	Indican	98-100	interleukin 1 alpha	Homo sapiens	245-253
34680443-5	2021	Furthermore, IS and UT mix induced the production of intracellular reactive oxygen species, and caspase-1 activity and IL-1beta secretion were reduced in the presence of antioxidant N-acetylcysteine.	Reactive Oxygen Species	67-90	interleukin 1 alpha	Homo sapiens	119-127
34680443-5	2021	Furthermore, IS and UT mix induced the production of intracellular reactive oxygen species, and caspase-1 activity and IL-1beta secretion were reduced in the presence of antioxidant N-acetylcysteine.	Acetylcysteine	182-198	interleukin 1 alpha	Homo sapiens	119-127
34559866-2	2021	Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1beta-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of the proinflammatory metabolite succinate and decreased concentrations of the anti-inflammatory metabolite itaconate.	Trichloroacetic Acid	247-250	interleukin 1 alpha	Homo sapiens	178-186
34559866-4	2021	Both succinate and IL-1beta were significantly associated with proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids.	Arachidonic Acid	163-179	interleukin 1 alpha	Homo sapiens	19-27
34559866-2	2021	Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1beta-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of the proinflammatory metabolite succinate and decreased concentrations of the anti-inflammatory metabolite itaconate.	Succinic Acid	333-342	interleukin 1 alpha	Homo sapiens	178-186
34559866-4	2021	Both succinate and IL-1beta were significantly associated with proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids.	Arachidonic Acid	209-225	interleukin 1 alpha	Homo sapiens	19-27
34559866-2	2021	Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1beta-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of the proinflammatory metabolite succinate and decreased concentrations of the anti-inflammatory metabolite itaconate.	itaconic acid	408-417	interleukin 1 alpha	Homo sapiens	178-186
34559866-4	2021	Both succinate and IL-1beta were significantly associated with proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids.	Eicosanoids	245-256	interleukin 1 alpha	Homo sapiens	19-27
34559866-5	2021	Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1beta-mediated proinflammatory eicosanoid signaling in pulmonary TB disease.	itaconic acid	48-57	interleukin 1 alpha	Homo sapiens	141-149
34559866-5	2021	Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1beta-mediated proinflammatory eicosanoid signaling in pulmonary TB disease.	Succinic Acid	78-87	interleukin 1 alpha	Homo sapiens	141-149
34559866-5	2021	Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1beta-mediated proinflammatory eicosanoid signaling in pulmonary TB disease.	Trichloroacetic Acid	98-101	interleukin 1 alpha	Homo sapiens	141-149
34559866-5	2021	Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1beta-mediated proinflammatory eicosanoid signaling in pulmonary TB disease.	Eicosanoids	175-185	interleukin 1 alpha	Homo sapiens	141-149
34554926-3	2021	The miR-19b-3p level in the intervertebral disc (IVD) tissues of IVDD patients and IL-1beta/TNF-alpha/hydrogen peroxide-treated human nucleus pulposus cells (HNPCs) was determined by quantitative real-time polymerase chain reaction (qRT-PCR).	Hydrogen Peroxide	102-119	interleukin 1 alpha	Homo sapiens	83-91
34572149-4	2021	The saturated free fatty acid palmitate with IL-1beta can synergistically induce catabolic effects in HACs.	saturated free fatty acid palmitate	4-39	interleukin 1 alpha	Homo sapiens	45-53
34554926-7	2021	In addition, the mechanism of action of miR-19b-3p was clarified using the PTEN inhibitor (VO-Ohpic triphosphate) or the mTOR inhibitor (Rapamycin) on the basis of IL-1beta intervention and miR-19b-3p mimics transfection.	mir-19b-3p	40-50	interleukin 1 alpha	Homo sapiens	164-172
34554926-7	2021	In addition, the mechanism of action of miR-19b-3p was clarified using the PTEN inhibitor (VO-Ohpic triphosphate) or the mTOR inhibitor (Rapamycin) on the basis of IL-1beta intervention and miR-19b-3p mimics transfection.	vo-ohpic triphosphate	91-112	interleukin 1 alpha	Homo sapiens	164-172
34554926-7	2021	In addition, the mechanism of action of miR-19b-3p was clarified using the PTEN inhibitor (VO-Ohpic triphosphate) or the mTOR inhibitor (Rapamycin) on the basis of IL-1beta intervention and miR-19b-3p mimics transfection.	Sirolimus	137-146	interleukin 1 alpha	Homo sapiens	164-172
34551296-8	2021	Together, our results suggest pTau activates IL-1beta via MyD88- and NLRP3-ASC-dependent pathways in myeloid cells, including microglia.	ptau	30-34	interleukin 1 alpha	Homo sapiens	45-53
34760801-7	2021	Conclusion: A mouthwash containing 1% of chitosan could suppress the expression of inflammatory mediators IL-1beta, COX-2, and iNOS.	Chitosan	41-49	interleukin 1 alpha	Homo sapiens	106-114
34533033-9	2021	Pathway analysis suggested gene expression changes, driven by a network of inflammatory cytokines centered on IL-1beta (interleukin 1beta), lead to repression of reno-protective eNOS (endothelial nitric oxide synthase) signaling during ADHF development, and following recovery, activation of glomerulosclerosis and reno-protective pathways and repression of proinflammatory/fibrotic pathways.	adhf	236-240	interleukin 1 alpha	Homo sapiens	110-118
34551296-4	2021	Treating microglia with pTau-containing neuronal media, exosomes, or PHFs causes IL-1beta activation, which is NLRP3, ASC, and caspase-1 dependent.	ptau	24-28	interleukin 1 alpha	Homo sapiens	81-89
34214916-9	2021	What"s more, DMEP activated the Nuclear factor-kappaB (NF-kappaB) pathway and levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were significantly upregulated, causing an inflammatory response.	dimethoxyethyl phthalate	13-17	interleukin 1 alpha	Homo sapiens	148-156
34548527-3	2021	In particular, metformin treatment has been shown to reduce expression of interleukin (IL-) 1beta during long-term exposure to the pro-inflammatory stimulus lipopolysaccharide (LPS) through a reduction in reactive oxygen species (ROS), which decreases the levels of the hypoxia-inducible factor (HIF) 1-alpha, and through enhanced expression of IL-10.	Metformin	15-24	interleukin 1 alpha	Homo sapiens	74-97
34548527-3	2021	In particular, metformin treatment has been shown to reduce expression of interleukin (IL-) 1beta during long-term exposure to the pro-inflammatory stimulus lipopolysaccharide (LPS) through a reduction in reactive oxygen species (ROS), which decreases the levels of the hypoxia-inducible factor (HIF) 1-alpha, and through enhanced expression of IL-10.	Reactive Oxygen Species	205-228	interleukin 1 alpha	Homo sapiens	74-97
34548527-3	2021	In particular, metformin treatment has been shown to reduce expression of interleukin (IL-) 1beta during long-term exposure to the pro-inflammatory stimulus lipopolysaccharide (LPS) through a reduction in reactive oxygen species (ROS), which decreases the levels of the hypoxia-inducible factor (HIF) 1-alpha, and through enhanced expression of IL-10.	Reactive Oxygen Species	230-233	interleukin 1 alpha	Homo sapiens	74-97
34632188-7	2021	Furthermore, 1,4-naphthoquinone potently suppressed the production and secretion of key proinflammatory cytokine proteins IL-8, IL-1beta, IL-10, TNF-alpha, and IL-6 in LPS-stimulated PMA-induced human THP-1 macrophages.	1,4-naphthoquinone	13-31	interleukin 1 alpha	Homo sapiens	128-136
34355225-7	2021	The interleukin (IL)-1beta-induced release of inflammatory cytokines IL-8 and tumor necrosis factor (TNF)-alpha in human chondrosarcoma cells was inhibited by monapurpureusone (8) and monascuspirolide B (14).	monapurpureusone	159-175	interleukin 1 alpha	Homo sapiens	4-26
34355225-7	2021	The interleukin (IL)-1beta-induced release of inflammatory cytokines IL-8 and tumor necrosis factor (TNF)-alpha in human chondrosarcoma cells was inhibited by monapurpureusone (8) and monascuspirolide B (14).	Monascuspirolide B	184-202	interleukin 1 alpha	Homo sapiens	4-26
34664888-2	2021	Systemic pro-inflammatory cytokines released from synovial tissues in rheumatoid arthritis, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, could have direct effects on cardiac electrophysiology, particularly changes in the expression and function of potassium and calcium channels, resulting in QT interval prolongation on surface electrocardiogram (ECG) and an increased predisposition to develop lethal ventricular arrhythmias.	Potassium	274-283	interleukin 1 alpha	Homo sapiens	100-122
34664888-2	2021	Systemic pro-inflammatory cytokines released from synovial tissues in rheumatoid arthritis, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, could have direct effects on cardiac electrophysiology, particularly changes in the expression and function of potassium and calcium channels, resulting in QT interval prolongation on surface electrocardiogram (ECG) and an increased predisposition to develop lethal ventricular arrhythmias.	Calcium	288-295	interleukin 1 alpha	Homo sapiens	100-122
34146555-10	2021	Moreover, melatonin through its anti-inflammatory effects, can attenuate the increased levels of nuclear factor kappa B, tumor necrosis factor alpha, transforming growth factor beta 1, SMAD2, interleukin (IL)-4, IL-4 receptor-a1 (IL4ra1), and IL-1 beta following lung radiation.	Melatonin	10-19	interleukin 1 alpha	Homo sapiens	243-252
34576117-1	2021	We aimed to investigate the effect of acute glucose shift on the activation of the NLRP3 inflammasome, IL-1beta secretion, and underlying signaling pathways in THP-1 cells.	Glucose	44-51	interleukin 1 alpha	Homo sapiens	103-111
34576117-6	2021	Further analysis using inhibitors of p38 MAPK, JNK, and NF-kappaB indicated that acute glucose shifts promoted IL-1beta secretion by activating the signaling pathway in a ROS-MAPK-NF-kappaB-NLRP3 inflammasome in THP-1 cells.	Glucose	87-94	interleukin 1 alpha	Homo sapiens	111-119
34576117-6	2021	Further analysis using inhibitors of p38 MAPK, JNK, and NF-kappaB indicated that acute glucose shifts promoted IL-1beta secretion by activating the signaling pathway in a ROS-MAPK-NF-kappaB-NLRP3 inflammasome in THP-1 cells.	Reactive Oxygen Species	171-174	interleukin 1 alpha	Homo sapiens	111-119
34433619-4	2021	Phagocytosis of silica particles by macrophages is followed by recruitment of mitochondria to phagosomes, generation of mitochondrial reactive oxygen species, and cytokine (IL-1beta, TNF-alpha, IFN-beta) release.	Silicon Dioxide	16-22	interleukin 1 alpha	Homo sapiens	173-181
34265624-7	2021	In comparison, OEA and PEA attenuated the TLR3-induced hyperthermia, although only OEA attenuated the expression of hyperthermia-related genes (IL-1beta, iNOS, COX2 and m-PGES) in the hypothalamus.	oleoylethanolamide	83-86	interleukin 1 alpha	Homo sapiens	144-152
34573091-6	2021	During the polarization process, diHEP-DPA treatment decreased the concentration of TGF-beta1, IL-1beta, IL-6, and TNF-alpha in culture supernatants via inhibiting the NF-kappaB pathway.	dihep-dpa	33-42	interleukin 1 alpha	Homo sapiens	95-103
34567413-7	2021	Olaparib reduced the inflammation score, the concentration of IL-1beta and IL-6, enhanced the level of IL-10, and decreased the intestinal permeability in TNBS-colitis.	olaparib	0-8	interleukin 1 alpha	Homo sapiens	62-70
34572676-5	2021	The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet"s disease treatment, as well as in reducing the release of inflammatory cells such as TNFalpha, IL-8, and IL-1beta, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties.	Adenylyl sulfate	45-49	interleukin 1 alpha	Homo sapiens	254-262
34265332-8	2021	The administered nanodevice (intravenously by tail vein injection) accumulated in the injured lungs and the controlled dexamethasone release reduces markedly the inflammatory response (TNF-alpha IL-6 and IL-1beta levels).	Dexamethasone	119-132	interleukin 1 alpha	Homo sapiens	204-212
34568239-1	2021	Anti-interleukin 1 agents are used successfully in colchicine-resistant or intolerant Familial Mediterranean Fever (FMF) patients.	Colchicine	51-61	interleukin 1 alpha	Homo sapiens	5-18
34566947-12	2021	Protease allergen of nTyr-p3 significantly increased the levels of pro-inflammatory cytokines (IL-6 and TNF-alpha), chemokine (IL-8), and IL-1beta in epithelial cells.	ntyr-p3	21-28	interleukin 1 alpha	Homo sapiens	138-146
34495872-7	2021	Administration of IPI504 at 0.5-5 muM can significantly inhibit the induction of IL-1beta, IL-6, IL-8, MCP-1 and VEGFA in senescent ARPE-19 and the senescence-mediated migration of retinal capillary endothelial cells in vitro.	tanespimycin	18-24	interleukin 1 alpha	Homo sapiens	81-89
34572016-6	2021	We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-kappaB activation, and subsequent TNF and IL-1beta release, even at low nM concentrations.	Reactive Oxygen Species	22-45	interleukin 1 alpha	Homo sapiens	125-133
34572016-6	2021	We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-kappaB activation, and subsequent TNF and IL-1beta release, even at low nM concentrations.	Reactive Oxygen Species	47-50	interleukin 1 alpha	Homo sapiens	125-133
34566947-17	2021	Among the pharmacologic inhibitors, the most effective inhibitor of the nTyr-p3 in the induction of IL-8 or IL-1beta levels was GB88 followed by SBTI, MAPK/ERK, ERK, and p38 inhibitors.	ntyr-p3	72-79	interleukin 1 alpha	Homo sapiens	108-116
34566947-17	2021	Among the pharmacologic inhibitors, the most effective inhibitor of the nTyr-p3 in the induction of IL-8 or IL-1beta levels was GB88 followed by SBTI, MAPK/ERK, ERK, and p38 inhibitors.	GB88	128-132	interleukin 1 alpha	Homo sapiens	108-116
34286801-4	2021	In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol.	Ethanol	249-256	interleukin 1 alpha	Homo sapiens	94-102
34286801-4	2021	In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol.	Ethanol	249-256	interleukin 1 alpha	Homo sapiens	187-195
34286801-4	2021	In macrophages, melanoidins significantly suppress the mRNA expression of interleukin (Il)-6, Il-1beta and tumor necrosis factor alpha (Tnf-alpha) with a concomitant inhibitory effect on IL-1beta, IL-6 and TNFalpha secretion, which are increased by ethanol.	melanoidin polymers	16-27	interleukin 1 alpha	Homo sapiens	94-102
34251416-2	2021	We previously found that INAVA has dual and competing functions: one at lateral membranes where it affects mucosal barrier function and the other in the cytosol where INAVA enhances IL-1beta signal transduction and protein ubiquitination and forms puncta.	inava	25-30	interleukin 1 alpha	Homo sapiens	182-190
34251416-2	2021	We previously found that INAVA has dual and competing functions: one at lateral membranes where it affects mucosal barrier function and the other in the cytosol where INAVA enhances IL-1beta signal transduction and protein ubiquitination and forms puncta.	inava	167-172	interleukin 1 alpha	Homo sapiens	182-190
34147477-4	2021	Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta).	icariin	29-36	interleukin 1 alpha	Homo sapiens	163-171
34147477-4	2021	Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta).	icaritin	41-49	interleukin 1 alpha	Homo sapiens	163-171
34147477-5	2021	Pre-treatment with IGF-1 receptor antagonist JB-1 could significantly block the anti-inflammatory effects of icariin and icaritin on LPS-induced up-regulations of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	icariin	109-116	interleukin 1 alpha	Homo sapiens	174-182
34147477-5	2021	Pre-treatment with IGF-1 receptor antagonist JB-1 could significantly block the anti-inflammatory effects of icariin and icaritin on LPS-induced up-regulations of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	icaritin	121-129	interleukin 1 alpha	Homo sapiens	174-182
34174588-4	2021	RESULTS: The expression for ACE2 in HGnF was significantly elevated after PgLPS or IL1beta, TNFalpha, PGE2 treatment.	Dinoprostone	102-106	interleukin 1 alpha	Homo sapiens	83-90
34566523-6	2021	Result: The levels of sPLA2-IIa and IL-1beta reduced significantly in both groups, but more when ezetimibe and rosuvastatin were coadministered (sPLA2-IIa: 6.16 +- 2.67 vs. 7.42 +- 3.53 ng/ml, p=0.01; IL-1beta: 37.39 +- 26.25 vs. 48.98 +- 32.26 pg/ml, p=0.01).	Ezetimibe	97-106	interleukin 1 alpha	Homo sapiens	36-44
34566523-6	2021	Result: The levels of sPLA2-IIa and IL-1beta reduced significantly in both groups, but more when ezetimibe and rosuvastatin were coadministered (sPLA2-IIa: 6.16 +- 2.67 vs. 7.42 +- 3.53 ng/ml, p=0.01; IL-1beta: 37.39 +- 26.25 vs. 48.98 +- 32.26 pg/ml, p=0.01).	Ezetimibe	97-106	interleukin 1 alpha	Homo sapiens	201-209
34566523-6	2021	Result: The levels of sPLA2-IIa and IL-1beta reduced significantly in both groups, but more when ezetimibe and rosuvastatin were coadministered (sPLA2-IIa: 6.16 +- 2.67 vs. 7.42 +- 3.53 ng/ml, p=0.01; IL-1beta: 37.39 +- 26.25 vs. 48.98 +- 32.26 pg/ml, p=0.01).	Rosuvastatin Calcium	111-123	interleukin 1 alpha	Homo sapiens	36-44
34566523-6	2021	Result: The levels of sPLA2-IIa and IL-1beta reduced significantly in both groups, but more when ezetimibe and rosuvastatin were coadministered (sPLA2-IIa: 6.16 +- 2.67 vs. 7.42 +- 3.53 ng/ml, p=0.01; IL-1beta: 37.39 +- 26.25 vs. 48.98 +- 32.26 pg/ml, p=0.01).	Rosuvastatin Calcium	111-123	interleukin 1 alpha	Homo sapiens	201-209
34575489-4	2021	The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay.	protocatechuic acid	32-35	interleukin 1 alpha	Homo sapiens	226-234
34575489-4	2021	The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay.	protocatechuic acid	136-139	interleukin 1 alpha	Homo sapiens	226-234
34229406-0	2021	Microglia-derived IL-1beta promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2alpha/ATF4/CHOP upon arsenic exposure.	Arsenic	130-137	interleukin 1 alpha	Homo sapiens	18-26
34229406-5	2021	Our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of IL-1beta and ER stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation.	Arsenic	31-38	interleukin 1 alpha	Homo sapiens	121-129
34229406-5	2021	Our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of IL-1beta and ER stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation.	Minocycline	186-197	interleukin 1 alpha	Homo sapiens	121-129
34502510-5	2021	1,25(OH)2D3 was administered to the cells with or without interleukin 1 beta (IL-1beta).	Calcitriol	0-11	interleukin 1 alpha	Homo sapiens	78-86
34289257-5	2021	Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	181-206	interleukin 1 alpha	Homo sapiens	0-22
34078001-6	2021	RESULTS: We found that FA activated SIRT1/AMPK/PGC-1alpha signaling pathway and attenuated IL-1beta-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE2 , nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress.	Nitrites	194-201	interleukin 1 alpha	Homo sapiens	91-99
34117813-10	2021	Results showed that the levels of GnT-V and beta1,6 GlcNAc on the VE-cadherin were decreased in the presence of IL-1beta, while the level of monocyte transendothelial migration was increased.	,6 glcnac	49-58	interleukin 1 alpha	Homo sapiens	112-120
34157359-13	2021	Finally, H2S inhibited NLRP3 inflammasome activation and decreased the level of IL-1beta by disrupting TGF-beta1 signaling.	Deuterium	9-12	interleukin 1 alpha	Homo sapiens	80-88
34061447-3	2021	RESULT: We found that linc00152 was not only up-regulated in rheumatoid arthritis fibroblast-like synoviocytes (RAFLS), but also stimulated by TNF-alpha/IL-1beta in adose- and time-dependent manner in RAFLS and this expression depends on the NF-kappaB signaling pathway.	adose	165-170	interleukin 1 alpha	Homo sapiens	153-161
34116285-9	2021	Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05).	bbg	55-58	interleukin 1 alpha	Homo sapiens	12-20
34116285-9	2021	Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05).	Glyburide	149-158	interleukin 1 alpha	Homo sapiens	12-20
34116285-9	2021	Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05).	Glyburide	149-158	interleukin 1 alpha	Homo sapiens	110-118
34116285-9	2021	Lower serum IL-1beta levels were detected in the EAM + BBG group than in the EAM1 group (P < 0.05), and serum IL-1beta and IL-18 levels in the EAM + glyburide group were lower than those in the EAM2 group (P < 0.05).	eam2	194-198	interleukin 1 alpha	Homo sapiens	12-20
34078001-2	2021	We aimed to determine the effects of ferulic acid (FA) on IL-1beta-induced osteoarthritis chondrocyte degeneration.	ferulic acid	37-49	interleukin 1 alpha	Homo sapiens	58-66
34078001-6	2021	RESULTS: We found that FA activated SIRT1/AMPK/PGC-1alpha signaling pathway and attenuated IL-1beta-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE2 , nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress.	Dinoprostone	187-191	interleukin 1 alpha	Homo sapiens	91-99
34250664-0	2021	Vorinostat ameliorates IL-1alpha-induced reduction of type II collagen by inhibiting the expression of ELF3 in chondrocytes.	Vorinostat	0-10	interleukin 1 alpha	Homo sapiens	23-32
34192661-7	2021	Under IL-1beta stress, blocking HOTAIR was responsible to high mitochondrial activity and low early apoptosis rate, accompanied with increased B cell lymphoma (Bcl)-2 and LC3B-II/I proteins, boosted IL-10 and SOD productions, suppressed cleaved caspase-3 and p62 proteins, and decreased MDA and ROS levels, as well as elevated secretions of Type II collagen, Type X collagen, SOX9, MMP-13, IL-6, and TNF-alpha.	Reactive Oxygen Species	295-298	interleukin 1 alpha	Homo sapiens	6-14
34192661-8	2021	Moreover, miR-222-3p was a target of HOTAIR, and its overexpression and knockdown could suppress and aggravate IL-1beta-induced chondrocytes injury.	mir-222-3p	10-20	interleukin 1 alpha	Homo sapiens	111-119
34250664-6	2021	In this study, our results demonstrate that treatment with vorinostat prevents interleukin 1alpha (IL-1alpha)-induced reduction of type II collagen at both gene and protein levels.	Vorinostat	59-69	interleukin 1 alpha	Homo sapiens	79-97
34250664-6	2021	In this study, our results demonstrate that treatment with vorinostat prevents interleukin 1alpha (IL-1alpha)-induced reduction of type II collagen at both gene and protein levels.	Vorinostat	59-69	interleukin 1 alpha	Homo sapiens	99-108
34250664-7	2021	Treatment with vorinostat reduced the IL-1alpha-induced production of mitochondrial reactive oxygen species (ROS) in T/C-28a2 cells.	Vorinostat	15-25	interleukin 1 alpha	Homo sapiens	38-47
34338401-10	2021	Additionally, exposure to nigericin sodium salt, an agonist of the NLRP3 inflammasome, upregulated expression of the NLRP3 inflammasome accompanied by the release of IL-1beta and IL-18.	Nigericin sodium	26-47	interleukin 1 alpha	Homo sapiens	166-174
34250664-7	2021	Treatment with vorinostat reduced the IL-1alpha-induced production of mitochondrial reactive oxygen species (ROS) in T/C-28a2 cells.	Reactive Oxygen Species	84-107	interleukin 1 alpha	Homo sapiens	38-47
34250664-7	2021	Treatment with vorinostat reduced the IL-1alpha-induced production of mitochondrial reactive oxygen species (ROS) in T/C-28a2 cells.	Reactive Oxygen Species	109-112	interleukin 1 alpha	Homo sapiens	38-47
34250664-8	2021	Additionally, vorinostat rescued the IL-1alpha-induced decrease in the expression of the collagen type II a1 (Col2a1) gene and the expression of Sry-related HMG box 9 (SOX-9).	Vorinostat	14-24	interleukin 1 alpha	Homo sapiens	37-46
34250664-10	2021	Furthermore, vorinostat suppressed the expression of E74-like factor 3 (ELF3), which is a key transcription factor that plays a pivotal role in the IL-1alpha-induced reduction of type II collagen.	Vorinostat	13-23	interleukin 1 alpha	Homo sapiens	148-157
34075628-0	2021	Nitrogen-containing Bisphosphonates and Lipopolysaccharide Mutually Augment Inflammation via ATP- and IL-1beta-mediated Production of NETs.	Nitrogen	0-8	interleukin 1 alpha	Homo sapiens	102-110
34075628-0	2021	Nitrogen-containing Bisphosphonates and Lipopolysaccharide Mutually Augment Inflammation via ATP- and IL-1beta-mediated Production of NETs.	Diphosphonates	20-35	interleukin 1 alpha	Homo sapiens	102-110
34075628-10	2021	(iv) Ale increased or tended to increase various cytokines, and LPS augmented these effects, especially that on IL-1beta.	Alendronate	5-8	interleukin 1 alpha	Homo sapiens	112-120
34075628-14	2021	(viii) Stimulation of P2X7 receptors by ATP induced IL-1beta in ear-pinnas.	Adenosine Triphosphate	40-43	interleukin 1 alpha	Homo sapiens	52-60
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	n-bps	31-36	interleukin 1 alpha	Homo sapiens	233-241
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	n-bps	31-36	interleukin 1 alpha	Homo sapiens	332-340
34250664-11	2021	Also, the overexpression of ELF3 abolished the protective effects of vorinostat against IL-1alpha-induced loss of type 2 collagen by inhibiting the expression of SOX-9 whilst increasing the expression of MMP-13.	Vorinostat	69-79	interleukin 1 alpha	Homo sapiens	88-97
34294366-4	2021	Moreover, hucMSC-Exo significantly down-regulated the levels of inflammatory cytokines IL-6, IL-1beta, and TNF-alpha in APAP-treated livers.	Acetaminophen	120-124	interleukin 1 alpha	Homo sapiens	93-101
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	Adenosine Triphosphate	88-91	interleukin 1 alpha	Homo sapiens	332-340
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	n-bps	138-143	interleukin 1 alpha	Homo sapiens	233-241
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	n-bps	138-143	interleukin 1 alpha	Homo sapiens	332-340
34075628-16	2021	These results suggest that (1) N-BPs induce both early- and late-phase inflammation via ATP-production and P2X7-receptor stimulation, (2) N-BPs and LPS induce mutually augmenting responses both early and late phases via ATP-mediated IL-1beta production by neutrophils, macrophages, and/or dendritic cells, and (3) NET production by IL-1beta-stimulated neutrophils may mediate the late phase, leading to prolonged inflammation.	Adenosine Triphosphate	220-223	interleukin 1 alpha	Homo sapiens	233-241
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Limonins	0-9	interleukin 1 alpha	Homo sapiens	84-93
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Limonins	0-9	interleukin 1 alpha	Homo sapiens	95-103
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 1 alpha	Homo sapiens	84-93
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 1 alpha	Homo sapiens	95-103
34578957-3	2021	TPA (5 muM) significantly induced cytotoxicity of NHDF, where a robust increase in the interleukin (IL)-1beta mRNA among the various pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	87-109
34578957-4	2021	The skin fibroblastic cytotoxicity and IL-1beta expression induced by TPA were significantly ameliorated by a treatment with 100 nM of kaempferol.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 alpha	Homo sapiens	39-47
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	nhdf	254-258	interleukin 1 alpha	Homo sapiens	220-228
34578957-4	2021	The skin fibroblastic cytotoxicity and IL-1beta expression induced by TPA were significantly ameliorated by a treatment with 100 nM of kaempferol.	kaempferol	135-145	interleukin 1 alpha	Homo sapiens	39-47
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	kaempferol	29-39	interleukin 1 alpha	Homo sapiens	220-228
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	interleukin 1 alpha	Homo sapiens	220-228
34803441-8	2021	Currently corticosteroids, IL-6 blockers, or IL-1 blockers are most widely used for treating COVID-CS.	covid-cs	93-101	interleukin 1 alpha	Homo sapiens	45-49
34304130-17	2021	Also, YAN alleviated ethanol-induced inflammation by down-regulating the inflammation-related gene IL-6, IL-1beta and TNF-alpha expression.	Ethanol	21-28	interleukin 1 alpha	Homo sapiens	105-113
34504537-8	2021	EFE inhibited the expression of MMP-1, MMP-3, and proinflammatory cytokines (TNF-alpha, IL-6, and IL-8) in IL-1beta-stimulated HGFs through the inhibition of IL-1beta-induced MAPK/STAT-3 activation.	EFE	0-3	interleukin 1 alpha	Homo sapiens	107-115
34504537-8	2021	EFE inhibited the expression of MMP-1, MMP-3, and proinflammatory cytokines (TNF-alpha, IL-6, and IL-8) in IL-1beta-stimulated HGFs through the inhibition of IL-1beta-induced MAPK/STAT-3 activation.	EFE	0-3	interleukin 1 alpha	Homo sapiens	158-166
34497153-7	2021	In inflammatory conditions (when the cells were exposed to the OA-related cytokine interleukin (IL)-1beta), 51 genes were upregulated and 42 downregulated by ibuprofen with fold change >1.5 in either direction.	Ibuprofen	158-167	interleukin 1 alpha	Homo sapiens	83-105
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	artenimol	105-108	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	Mesalamine	117-138	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	5-Aminosalicylic acid	140-145	interleukin 1 alpha	Homo sapiens	57-65
34438368-7	2021	Additionally, inhibition of NF-kappaB by PDTC mitigated the si-NLRC5-mediated promotion of IL-1beta-induced inflammatory injury in chondrocytes.	prolinedithiocarbamate	41-45	interleukin 1 alpha	Homo sapiens	91-99
34438368-4	2021	Overexpression of NLRC5 in chondrocytes significantly suppressed IL-1beta-induced inflammatory response through inhibiting the production of multiple inflammatory mediators including inducible nitric oxide synthases (iNOS), and cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), NO, TNF-alpha and IL-6, as well matrix metalloproteinase 3 (MMP-3) and MMP-13.	Dinoprostone	254-270	interleukin 1 alpha	Homo sapiens	65-73
34435480-0	2021	Expression of NLR and IL-1beta and their predictive efficacy value in acute myocardial infarction patients treated with aspirin combined with clopidogrel.	Aspirin	120-127	interleukin 1 alpha	Homo sapiens	22-30
34435480-0	2021	Expression of NLR and IL-1beta and their predictive efficacy value in acute myocardial infarction patients treated with aspirin combined with clopidogrel.	Clopidogrel	142-153	interleukin 1 alpha	Homo sapiens	22-30
34438368-4	2021	Overexpression of NLRC5 in chondrocytes significantly suppressed IL-1beta-induced inflammatory response through inhibiting the production of multiple inflammatory mediators including inducible nitric oxide synthases (iNOS), and cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), NO, TNF-alpha and IL-6, as well matrix metalloproteinase 3 (MMP-3) and MMP-13.	Dinoprostone	272-276	interleukin 1 alpha	Homo sapiens	65-73
34232079-2	2021	In this mSphere of Influence article, he reflects on how the paper "Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha" by Tannahill et al.	Succinic Acid	68-77	interleukin 1 alpha	Homo sapiens	117-125
34217687-7	2021	Ox-LDL induced NF-kappaB/NLRP3 pathway activation by inducing C-reactive protein expression, NLRP3 activation, caspase-1 activation, and IL-1beta secretion, which were inhibited by pretreatment with the combination of PAVA and RSV.	pelargonic acid vanillylamide	218-222	interleukin 1 alpha	Homo sapiens	137-145
34217687-7	2021	Ox-LDL induced NF-kappaB/NLRP3 pathway activation by inducing C-reactive protein expression, NLRP3 activation, caspase-1 activation, and IL-1beta secretion, which were inhibited by pretreatment with the combination of PAVA and RSV.	Rosuvastatin Calcium	227-230	interleukin 1 alpha	Homo sapiens	137-145
34124933-0	2021	Rewiring of lactate-IL-1beta auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma.	Lactic Acid	12-19	interleukin 1 alpha	Homo sapiens	20-28
34153368-5	2021	The PrL and IL of the mPFC, the BLA of the amygdala, the CA1, CA2, CA3, and DG of the hippocampus but not the Cg1 presented hyperactive IL-1beta expression in response to morphine"s aversion and reward.	Morphine	171-179	interleukin 1 alpha	Homo sapiens	136-144
34573138-8	2021	Elevation of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and NF-kB and reduction of the antioxidant enzymes catalase and glutathione peroxidase-1 (GPx-1) were induced by TMT and ameliorated by inhibitors of LOX and COX-2 enzymes.	trimethyltin	178-181	interleukin 1 alpha	Homo sapiens	44-52
34124933-3	2021	Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1beta was concomitant with elevated levels of core circadian regulators Clock and Bmal1.	Lactic Acid	17-24	interleukin 1 alpha	Homo sapiens	73-81
34124933-5	2021	Lactate mediated deacetylation of Bmal1 and its interaction with Clock, regulate IL-1beta levels and vice versa.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	81-89
34124933-7	2021	ChIP-re-ChIP revealed that lactate-IL-1beta crosstalk positively affects co-recruitment of Clock-Bmal1 to these E-box sites.	Lactic Acid	27-34	interleukin 1 alpha	Homo sapiens	35-43
34428217-5	2021	Experiments demonstrate for the first time that plasma concentrations of Acetylsalicylic acid significantly increased TLR ligand-triggered IL-1beta, IL-10, and IL-6 production in a dose-dependent manner.	Aspirin	73-93	interleukin 1 alpha	Homo sapiens	139-147
34124933-10	2021	TCGA data analysis suggested the presence of lactate- IL-1beta-crosstalk in other cancers.	Lactic Acid	45-52	interleukin 1 alpha	Homo sapiens	54-62
34428217-8	2021	Low PGE2 levels were at least involved in the enhanced IL-1beta production by Acetylsalicylic acid.	Dinoprostone	4-8	interleukin 1 alpha	Homo sapiens	55-63
34124933-13	2021	Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals.	Lactic Acid	161-168	interleukin 1 alpha	Homo sapiens	77-85
34428217-8	2021	Low PGE2 levels were at least involved in the enhanced IL-1beta production by Acetylsalicylic acid.	Aspirin	78-98	interleukin 1 alpha	Homo sapiens	55-63
34124933-13	2021	Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals.	Lactic Acid	161-168	interleukin 1 alpha	Homo sapiens	152-160
34425806-0	2021	Norepinephrine modulates IL-1beta-induced catabolic response of human chondrocytes.	Norepinephrine	0-14	interleukin 1 alpha	Homo sapiens	25-33
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Propranolol	69-80	interleukin 1 alpha	Homo sapiens	31-39
34425806-9	2021	In addition, NE significantly inhibited IL-1beta-induced release of glycosaminoglycan (GAG) from cartilage explant culture.	Glycosaminoglycans	68-85	interleukin 1 alpha	Homo sapiens	40-48
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Propranolol	69-80	interleukin 1 alpha	Homo sapiens	150-158
34425806-9	2021	In addition, NE significantly inhibited IL-1beta-induced release of glycosaminoglycan (GAG) from cartilage explant culture.	Glycosaminoglycans	87-90	interleukin 1 alpha	Homo sapiens	40-48
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Atenolol	82-90	interleukin 1 alpha	Homo sapiens	31-39
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Atenolol	82-90	interleukin 1 alpha	Homo sapiens	150-158
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Nebivolol	92-101	interleukin 1 alpha	Homo sapiens	31-39
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Nebivolol	92-101	interleukin 1 alpha	Homo sapiens	150-158
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Nadolol	107-114	interleukin 1 alpha	Homo sapiens	31-39
34425806-7	2021	Treatment of chondrocytes with IL-1beta and beta-blockers, including propranolol, atenolol, nebivolol, and nadolol, for 6 h significantly upregulated IL-1beta-induced expression of MMP-1, -3, and - 13, compared to chondrocytes treated with IL-1beta alone, indicating that antagonism of beta-AR confers catabolic signals.	Nadolol	107-114	interleukin 1 alpha	Homo sapiens	150-158
34445685-4	2021	Celecoxib and GS alone or co-incubated with IL-1beta significantly reduced expression and release of cyclooxygenase (COX)-2, prostaglandin (PG)E2, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and MMPs, while it increased Col2a1, compared to baseline or IL-1beta.	Celecoxib	0-9	interleukin 1 alpha	Homo sapiens	147-155
34445685-6	2021	Celecoxib and GS combination demonstrated an increased inhibitory effect on IL-1beta than that observed by each single treatment.	Celecoxib	0-9	interleukin 1 alpha	Homo sapiens	76-84
34426617-4	2021	The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1beta, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group.	dmek	4-8	interleukin 1 alpha	Homo sapiens	107-115
34489689-5	2021	The NACHT, leucine-rich repeat (LRR), and pyrin (PYD) domains-containing protein 3 (NLRP3) inflammasome regulates IL-1beta and IL-18 secretion and gasdermin D-mediated pyroptosis and plays a key role in innate immunity.	Leucine	11-18	interleukin 1 alpha	Homo sapiens	114-122
34445685-4	2021	Celecoxib and GS alone or co-incubated with IL-1beta significantly reduced expression and release of cyclooxygenase (COX)-2, prostaglandin (PG)E2, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and MMPs, while it increased Col2a1, compared to baseline or IL-1beta.	Prostaglandins	125-140	interleukin 1 alpha	Homo sapiens	44-52
34445685-4	2021	Celecoxib and GS alone or co-incubated with IL-1beta significantly reduced expression and release of cyclooxygenase (COX)-2, prostaglandin (PG)E2, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and MMPs, while it increased Col2a1, compared to baseline or IL-1beta.	Dinoprostone	140-145	interleukin 1 alpha	Homo sapiens	44-52
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	Chloroquine	23-25	interleukin 1 alpha	Homo sapiens	88-96
34440900-6	2021	DMF also inhibited the inflammatory response induced by IL-1beta/H2O2 and IL-1beta/TNFalpha, mimicking the inflammatory status of CF patients.	Dimethyl Fumarate	0-3	interleukin 1 alpha	Homo sapiens	56-64
34440900-6	2021	DMF also inhibited the inflammatory response induced by IL-1beta/H2O2 and IL-1beta/TNFalpha, mimicking the inflammatory status of CF patients.	Dimethyl Fumarate	0-3	interleukin 1 alpha	Homo sapiens	74-82
34440900-6	2021	DMF also inhibited the inflammatory response induced by IL-1beta/H2O2 and IL-1beta/TNFalpha, mimicking the inflammatory status of CF patients.	Hydrogen Peroxide	65-69	interleukin 1 alpha	Homo sapiens	56-64
34142814-12	2021	In addition, our data suggest that drugs that block the effects or the formation of IL-1beta would provide better treatment of amiodarone-induced immune-related adverse reactions.	Amiodarone	127-137	interleukin 1 alpha	Homo sapiens	84-92
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 1 alpha	Homo sapiens	88-96
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 1 alpha	Homo sapiens	187-195
34452519-12	2021	Astodrimer sodium 1% significantly reduced the pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta, TNFalpha and TGFbeta and the chemokine MCP-1 in the serum, lung and trachea vs. PBS.	astodrimer sodium	0-17	interleukin 1 alpha	Homo sapiens	80-89
34452519-12	2021	Astodrimer sodium 1% significantly reduced the pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta, TNFalpha and TGFbeta and the chemokine MCP-1 in the serum, lung and trachea vs. PBS.	astodrimer sodium	0-17	interleukin 1 alpha	Homo sapiens	91-99
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	Chloroquine	23-25	interleukin 1 alpha	Homo sapiens	187-195
34280124-7	2021	Of note, blocking IL-1beta signaling with anti-human IL-1beta neutralizing antibody could reverse the stimulatory effect of PGE2 on CD82 in ESCs.	Dinoprostone	124-128	interleukin 1 alpha	Homo sapiens	18-26
34280124-7	2021	Of note, blocking IL-1beta signaling with anti-human IL-1beta neutralizing antibody could reverse the stimulatory effect of PGE2 on CD82 in ESCs.	Dinoprostone	124-128	interleukin 1 alpha	Homo sapiens	53-61
34280124-10	2021	This study suggests that CD82 should be a novel promotor for decidualization under a positive regulation of the COX-2/PGE2/IL-1beta positive feedback loop.	Dinoprostone	118-122	interleukin 1 alpha	Homo sapiens	123-131
34452455-7	2021	When the models were challenged with a combination of the bacterial toxins LPS and ATP, a release of the proinflammatory cytokines IL-1beta and IL-8 was observed, confirming that the model can generate an immune response.	Adenosine Triphosphate	83-86	interleukin 1 alpha	Homo sapiens	131-139
34515145-0	2022	Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1beta Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells.	Hydrogen Peroxide	0-17	interleukin 1 alpha	Homo sapiens	61-69
34646528-9	2021	Shikonin reversed the expression of the inflammatory cytokines TNF-alpha and IL-1beta and apoptosis-related molecules Bax, Bcl-2, and cleaved caspase 3 in LPS-induced NP cells.	shikonin	0-8	interleukin 1 alpha	Homo sapiens	77-85
34408814-2	2021	H2S has previously been shown to induce the secretion of the pro-inflammatory cytokines IL-1beta and IL-18 via the NLRP3 inflammasome in monocytes.	Deuterium	0-3	interleukin 1 alpha	Homo sapiens	88-96
34439835-5	2021	In vivo, patients (n = 85) with serum LDL-cholesterol (LDL-C) >100 mg/dL showed an increase in NCM, IL-1 beta, LPS-binding protein (LBP), and Castelli"s atherogenic risk index as compared to controls (n = 65) with optimal LDL-C concentrations (<=100 mg/dL).	Cholesterol	41-53	interleukin 1 alpha	Homo sapiens	100-109
34515145-8	2022	However, H2O2-mediated IL-1beta release itself occurs mainly via apoptosis.	Hydrogen Peroxide	9-13	interleukin 1 alpha	Homo sapiens	23-31
34421621-5	2021	We found that puerarin inhibited liver injury and inflammatory cell infiltration in lipopolysaccharide (LPS)/D-galactose (D-Gal)-induced acute liver failure and the liver pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in liver tissues with ALI and LPS-induced L-02 cells but upregulated the expression level of zinc finger E-box-binding homeobox 2 (ZEB2).	puerarin	14-22	interleukin 1 alpha	Homo sapiens	198-220
34355546-7	2022	Our findings indicated that melatonin is used as a complementary treatment to reduce the levels of TNF-alpha and IL-1beta cytokines, MDA, and NO levels in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 cytokine possesses no considerable changes.	Melatonin	28-37	interleukin 1 alpha	Homo sapiens	113-121
34515145-6	2022	We demonstrate that H2O2 primes as well as activates the NLRP3 inflammasome and thereby mediates IL-1beta production and release.	Hydrogen Peroxide	20-24	interleukin 1 alpha	Homo sapiens	97-105
34344357-15	2021	In vitro experiments, the process of IL-1beta augmenting TGF-beta1-induced EMT cannot be abrogated by glucocorticoid or montelukast sodium, but can be reversed by MAPK inhibitors.	montelukast	120-138	interleukin 1 alpha	Homo sapiens	37-45
34445126-0	2021	MAO-A Inhibition by Metaxalone Reverts IL-1beta-Induced Inflammatory Phenotype in Microglial Cells.	metaxalone	20-30	interleukin 1 alpha	Homo sapiens	39-47
34445126-8	2021	IL-1beta also augmented MAO-A expression/activity and malondialdehyde levels and decreased Nrf2 mRNA expression and protein levels.	Malondialdehyde	54-69	interleukin 1 alpha	Homo sapiens	0-8
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Adenosine Triphosphate	150-153	interleukin 1 alpha	Homo sapiens	69-77
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Nigericin	155-164	interleukin 1 alpha	Homo sapiens	69-77
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Uric Acid	169-185	interleukin 1 alpha	Homo sapiens	69-77
34344357-17	2021	The potential mechanism may be related to IL-1beta augmenting TGF-beta1-induced steroid-resistant EMT through MAPK signaling pathways.	Steroids	80-87	interleukin 1 alpha	Homo sapiens	42-50
34107730-7	2021	RIPC attenuated the IPT-induced increase in IL-1beta, E-selectin, sICAM-3 (soluble intercellular adhesion molecule 3), and s-thrombomodulin levels between the baseline and day 1 (P for interaction <0.1).	isoprothiolane	20-23	interleukin 1 alpha	Homo sapiens	44-52
34424286-6	2021	Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group.	mdr-pa	16-22	interleukin 1 alpha	Homo sapiens	98-106
34424286-6	2021	Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group.	s-pa	158-162	interleukin 1 alpha	Homo sapiens	98-106
34165617-6	2021	Pretreatment with NBMI successfully counteracted Pb-induced neuroinflammation by reducing IL-1beta (0.59-fold, p < 0.05) and GFAP expression levels.	N,N'-bis-2-mercaptoethylisophthalamide	18-22	interleukin 1 alpha	Homo sapiens	90-98
34165617-6	2021	Pretreatment with NBMI successfully counteracted Pb-induced neuroinflammation by reducing IL-1beta (0.59-fold, p < 0.05) and GFAP expression levels.	Lead	49-51	interleukin 1 alpha	Homo sapiens	90-98
34166911-9	2021	In the presence of 3D printed hypoxic U87 spheroids (h-U87), DD-LAGs induced cancer cell death, upregulated IL-1beta, and downregulated IL-10 resulting in CD3+, helper CD4+, and cytotoxic CD8+ proliferation.	dd-lags	61-68	interleukin 1 alpha	Homo sapiens	108-116
34218389-9	2021	Bupropion reduced IL-17A, TNFalpha, and IL-1beta protein levels in the cultures.	Bupropion	0-9	interleukin 1 alpha	Homo sapiens	40-48
34131437-8	2021	Moreover, knockdown of NLRC4 expression in HK2 cells treated with HG reduced the secretion of the inflammatory cytokines, IL-1beta and IL-18.	Mercury	66-68	interleukin 1 alpha	Homo sapiens	122-130
34372688-9	2021	RESULTS: Suramin inhibited IL-1beta-induced apoptosis, downregulated matrix metalloproteinase (MMP)-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, and ADAMTS-5, and upregulated collagen 2A (Col2a1) and aggrecan in IL-1beta-treated NP cells.	Suramin	9-16	interleukin 1 alpha	Homo sapiens	27-35
34372688-10	2021	IL-1beta-induced inflammation, assessed by IL-1beta, IL-8, and tumour necrosis factor alpha (TNF-alpha) upregulation, was alleviated by suramin treatment.	Suramin	136-143	interleukin 1 alpha	Homo sapiens	0-8
34372688-10	2021	IL-1beta-induced inflammation, assessed by IL-1beta, IL-8, and tumour necrosis factor alpha (TNF-alpha) upregulation, was alleviated by suramin treatment.	Suramin	136-143	interleukin 1 alpha	Homo sapiens	43-51
34372688-11	2021	Suramin suppressed IL-1beta-mediated proteoglycan depletion and the induction of MMP-3, ADAMTS-4, and pro-inflammatory gene expression in ex vivo experiments.	Suramin	0-7	interleukin 1 alpha	Homo sapiens	19-27
34216617-4	2021	We found that antimycin A-induced mitochondrial dysfunction caused caspase-1-dependent inflammasome activation and subsequent production of mature IL-1beta and IL-18 in human RPE cells.	Antimycin A	14-25	interleukin 1 alpha	Homo sapiens	147-155
34218389-10	2021	Nonetheless, bupropion increased IL-1beta (P < 0.0001), TNFalpha (P < 0.0001), and IL-17A (P < 0.05) mRNA levels.	Bupropion	13-22	interleukin 1 alpha	Homo sapiens	33-41
34180293-6	2021	Rodent studies provided strong support for ketamine-induced decreases in pro-inflammatory cytokines, namely in interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha and indicated anti-inflammatory effects on TRP metabolism, including decreases in the enzyme indoleamine 2,3-dioxygenase (IDO).	Ketamine	43-51	interleukin 1 alpha	Homo sapiens	111-133
34410877-0	2021	Diacerein Alone and in Combination with Infliximab Suppresses the Combined Proinflammatory Effects of IL-17A, IL-22, Oncostatin M, IL-1A, and TNF-alpha in Keratinocytes: A Potential Therapeutic Option in Psoriasis.	diacerein	0-9	interleukin 1 alpha	Homo sapiens	131-136
34452150-3	2021	5-FU activity leads to caspase-1 activation, secretion and maturation of interleukins (IL)-1, IL-18 and reactive oxygen species (ROS) generation.	Fluorouracil	0-4	interleukin 1 alpha	Homo sapiens	73-92
34139004-0	2021	Glucose regulates expression of pro-inflammatory genes IL-1beta and IL-12 through a mechanism involving hexosamine biosynthesis pathway dependent regulation of alphaEcatenin.	Glucose	0-7	interleukin 1 alpha	Homo sapiens	55-63
34175589-6	2021	RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta.	caryophyllene	68-71	interleukin 1 alpha	Homo sapiens	317-325
34139004-0	2021	Glucose regulates expression of pro-inflammatory genes IL-1beta and IL-12 through a mechanism involving hexosamine biosynthesis pathway dependent regulation of alphaEcatenin.	Hexosamines	104-114	interleukin 1 alpha	Homo sapiens	55-63
34139004-7	2021	We find that the reduction of alpha-E catenin level using siRNA attenuates the glucose induced changes of both IL-1beta and IL-12 mRNA levels under LPS stimulated condition but does not affect TNF-alpha expression.	Glucose	79-86	interleukin 1 alpha	Homo sapiens	111-119
34139004-8	2021	Together this indicates that alpha-E catenin can sense the changes in glucose levels in macrophages via hexosamine biosynthesis pathway and also can modulate the glucose induced gene expression of inflammatory markers such as IL-1beta and IL-12.	Glucose	162-169	interleukin 1 alpha	Homo sapiens	226-234
34439789-6	2021	Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1-2 and with relative PHE at days 7-8 or 9-10 for IL-1beta, IL-6, IL-8, and IL-10.	Phenylalanine	106-109	interleukin 1 alpha	Homo sapiens	134-142
34321071-2	2021	Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1beta.	Uric Acid	0-5	interleukin 1 alpha	Homo sapiens	87-95
34330980-6	2021	GSK101 reversed the IL-1beta-induced increase in expression of matrix metalloproteinase (MMP)-13 and decrease in expression of aggrecan.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	0-6	interleukin 1 alpha	Homo sapiens	20-28
34330980-8	2021	Furthermore, GSK101 increased AMPK phosphorylation and decreased IL-1beta-induced nuclear factor kappa B (NF-kappaB) phosphorylation.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	13-19	interleukin 1 alpha	Homo sapiens	65-73
34319853-7	2021	Significant decreases in interleukin- 1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels were obtained in cultures treated with FA-MTX-BSA NPs compared to the untreated culture in a dose-dependent pattern.	Methotrexate	172-175	interleukin 1 alpha	Homo sapiens	46-54
34350135-4	2021	Much research has focused on toll-like receptors and more recently the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 (NLRP3) inflammasome, which is required for the processing and release of IL-1beta.	Leucine	101-108	interleukin 1 alpha	Homo sapiens	222-230
34254088-5	2021	The critical role of the PBAE layer on oil droplets was established along with the retained biological activity of the drug as glycosaminoglycan (GAG) and collagen degradation induced by interleukin-1 (IL-1) was prevented by the novel technology.	Oils	39-42	interleukin 1 alpha	Homo sapiens	187-200
34314383-3	2021	Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5).	curcumol	19-27	interleukin 1 alpha	Homo sapiens	152-161
34312368-5	2021	Mechanically, C5aR1-positive neutrophil-secreted IL1beta and TNFalpha cooperatively activate ERK1/2 signaling, which phosphorylates WTAP at serine341 and thereby stabilizes WTAP protein.	serine341	140-149	interleukin 1 alpha	Homo sapiens	49-56
34385915-5	2021	Mechanistically, we found that SA suppressed the IL-1beta-induced activation of the mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappaB) pathways.	Shikimic Acid	31-33	interleukin 1 alpha	Homo sapiens	49-57
34335042-11	2021	The results showed that higher levels of ROS were observed upon treatment of chondrocytes and chondral OA with IL-1beta.	Reactive Oxygen Species	41-44	interleukin 1 alpha	Homo sapiens	111-119
34302034-3	2021	Galactose replacement alone blocked enhanced usage of the glycolysis pathway by IL1beta-activated chondrocytes as detected by real-time changes in the rates of proton acidification of the medium and changes in oxygen consumption.	Galactose	0-9	interleukin 1 alpha	Homo sapiens	80-87
34302034-3	2021	Galactose replacement alone blocked enhanced usage of the glycolysis pathway by IL1beta-activated chondrocytes as detected by real-time changes in the rates of proton acidification of the medium and changes in oxygen consumption.	Oxygen	210-216	interleukin 1 alpha	Homo sapiens	80-87
34302034-7	2021	Blocking baseline and IL1beta-enhanced MMP13 by galactose-replacement in human osteoarthritic chondrocyte cultures inversely paralleled increases in markers associated with mitochondrial recovery, phospho-AMPK, and PGC1alpha.	Galactose	48-57	interleukin 1 alpha	Homo sapiens	22-29
34285296-6	2021	Inflammatory markers induced by TNF-alpha, including IL-1, IL-6, MCP-1 and RANTES, were also suppressed following administration of clodronate.	Clodronic Acid	132-142	interleukin 1 alpha	Homo sapiens	53-57
34322217-9	2021	Results: Disulfiram induced a dose-dependent inhibition of ASC speck formation and IL-1beta release in cellular assays in vitro.	Disulfiram	9-19	interleukin 1 alpha	Homo sapiens	83-91
34350063-4	2021	Alternol triggered ICD in prostate cancer cells, as evidenced by the release of damage-associated molecular patterns (DAMPs) (i.e., calreticulin, CALR; high mobility group protein B1, HMGB1; and adenosine triphosphate, ATP) and pro-inflammatory cytokine (i.e., interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8) expression.	Alternol	0-8	interleukin 1 alpha	Homo sapiens	286-294
34275451-10	2021	Kaempferol-treatment could induce higher levels of IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma in the serum at 3 dpi which were then declined to normal levels at 5 dpi.	kaempferol	0-10	interleukin 1 alpha	Homo sapiens	51-59
34336106-3	2021	Further, our study revealed that arctiin and arctigenin suppressed the activation of NLRP3 inflammasome through the TLR-4/Myd88/NF-kappaB pathway and the silica-induced secretion of TNF-alpha, IL-1beta, TGF-beta, and alpha-SMA.	Silicon Dioxide	154-160	interleukin 1 alpha	Homo sapiens	193-201
34282169-9	2021	Moreover, co-culture of IL-1beta-stimulated hUCMSCs with embelin-treated breast cancer cells could effectively induce apoptosis in breast cancer cells.	embelin	57-64	interleukin 1 alpha	Homo sapiens	24-32
34335248-8	2021	Overexpressing the Drp1 expression counteracted the restraint of atractylenolide I on the release of IL-1beta of LPS/DSS-stimulated BMDMs.	(+)-Atractylenolide	65-80	interleukin 1 alpha	Homo sapiens	101-109
34266494-7	2021	Further results showed that Rabeprazole inhibited cell pyroptosis in gastric epithelial cells by alleviating GSDMD-executed pyroptosis, leading to decrease IL-1beta and IL-18 mature and secretion, which is attributed to NLRP3 inflammasome activation inhibition.	Rabeprazole	28-39	interleukin 1 alpha	Homo sapiens	156-164
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	interleukin 1 alpha	Homo sapiens	144-152
34371919-8	2021	We hypothesized that these alterations play an important modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1beta secretion in LPS-activated M-MPhis following caffeine treatment.	Caffeine	178-186	interleukin 1 alpha	Homo sapiens	124-132
34115964-3	2021	We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS.	Metformin	13-22	interleukin 1 alpha	Homo sapiens	67-89
34114792-7	2021	Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8.	nco-sp	10-16	interleukin 1 alpha	Homo sapiens	112-120
34114792-7	2021	Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8.	eo-stat-po	17-27	interleukin 1 alpha	Homo sapiens	112-120
34242238-9	2021	Following 10 weeks of implantation, RT-qPCR analyses of chondrocytes grown on ethanol-treated scaffolds showed greater expression levels for several cartilage-related genes compared to cells developed on untreated scaffolds with statistically significantly increased SRY-box transcription factor 5 (SOX5) and decreased interleukin-1alpha (inflammation-related) expression levels (p <= 0.05).	Ethanol	78-85	interleukin 1 alpha	Homo sapiens	319-337
34931978-10	2022	CONCLUSIONS: We describe in the present work a series of (1,2,5)oxadiazolo(3,4-b)pyrazine (furazano(3,4-b)pyrazine), potent inhibitors of IL-1beta secretion in human monocyte-derived macrophages allosteric modulators of the p38 MAP kinase A-loop regulatory site.	(1,2,5)oxadiazolo(3,4-b)pyrazine	57-89	interleukin 1 alpha	Homo sapiens	138-146
34931978-10	2022	CONCLUSIONS: We describe in the present work a series of (1,2,5)oxadiazolo(3,4-b)pyrazine (furazano(3,4-b)pyrazine), potent inhibitors of IL-1beta secretion in human monocyte-derived macrophages allosteric modulators of the p38 MAP kinase A-loop regulatory site.	furazano(3,4-b)pyrazine	91-114	interleukin 1 alpha	Homo sapiens	138-146
34236821-8	2021	MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin (IL)-6, IL-1beta, and IL-18).	mir-128-3p	0-10	interleukin 1 alpha	Homo sapiens	96-104
34356813-6	2021	Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS.	7-epi-Loliolide	0-12	interleukin 1 alpha	Homo sapiens	248-256
34356813-6	2021	Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta, by downregulating NLRP3 activated by PG-LPS.	pg-lps	295-301	interleukin 1 alpha	Homo sapiens	248-256
34306796-11	2021	After 2 treatments with aaPRP, severe patients" plasma IL-1beta concentration decreased 12.48 pg/mL, while critical patients" plasma IL-1beta concentration increased to 18.77 pg/mL.	aaprp	24-29	interleukin 1 alpha	Homo sapiens	55-63
34306796-11	2021	After 2 treatments with aaPRP, severe patients" plasma IL-1beta concentration decreased 12.48 pg/mL, while critical patients" plasma IL-1beta concentration increased to 18.77 pg/mL.	aaprp	24-29	interleukin 1 alpha	Homo sapiens	133-141
34306796-15	2021	Conclusion: The use of aaPRP may prevent pulmonary fibrosis in severe COVID-19 patients through the reduction of patients" plasma IL-1beta concentration and the amelioration of PaO2/FiO2 ratio.	aaprp	23-28	interleukin 1 alpha	Homo sapiens	130-138
34281258-7	2021	PMU-treated HEK293 cells acquired a pro-inflammatory phenotype, producing reactive oxygen species (ROS) and cytokines IL-1beta and TNF-alpha.	CHEMBL1800452	0-3	interleukin 1 alpha	Homo sapiens	118-126
34262692-11	2021	Interleukin (IL)-8, IL-10, IL-1alpha, and tissue inhibitor of metalloproteinase (TIMP)-1 concentrations were significantly increased in the culture medium of cells exposed to PM2.5, and budesonide significantly reduced the changes in IL-8, IL-1alpha, and TIMP-1.	Budesonide	186-196	interleukin 1 alpha	Homo sapiens	27-36
34357020-7	2021	Dysfunctional mitochondria release high levels of reactive oxygen species (ROS), which can activate pro-inflammatory pathways such as IL-1beta and IL-6.	Reactive Oxygen Species	50-73	interleukin 1 alpha	Homo sapiens	134-142
34262692-11	2021	Interleukin (IL)-8, IL-10, IL-1alpha, and tissue inhibitor of metalloproteinase (TIMP)-1 concentrations were significantly increased in the culture medium of cells exposed to PM2.5, and budesonide significantly reduced the changes in IL-8, IL-1alpha, and TIMP-1.	Budesonide	186-196	interleukin 1 alpha	Homo sapiens	240-249
34357020-7	2021	Dysfunctional mitochondria release high levels of reactive oxygen species (ROS), which can activate pro-inflammatory pathways such as IL-1beta and IL-6.	Reactive Oxygen Species	75-78	interleukin 1 alpha	Homo sapiens	134-142
34215299-0	2021	Identification and validation of key long non-coding RNAs in resveratrol protect against IL-1beta-treated chondrocytes via integrated bioinformatic analysis.	Resveratrol	61-72	interleukin 1 alpha	Homo sapiens	89-97
34215299-2	2021	This study aimed to identify and validate the key lncRNAs in resveratrol protect against IL-1beta-treated chondrocytes.	Resveratrol	61-72	interleukin 1 alpha	Homo sapiens	89-97
34227646-3	2021	It was observed that the expression of IL-1beta, IL-6, IL-8 and TNFalpha in LPS-induced HGFs was significantly downregulated by RSV in a dose-dependent manner.	Resveratrol	128-131	interleukin 1 alpha	Homo sapiens	39-47
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 1 alpha	Homo sapiens	256-264
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	interleukin 1 alpha	Homo sapiens	103-111
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	Resveratrol	216-219	interleukin 1 alpha	Homo sapiens	256-264
34281061-4	2021	Therefore, the aim of our study was to investigate the relationship between 25(OH)D concentration and selected cytokines-IL-6, TNF-alpha, and IL-1beta, which are hemogram parameters for professional football players.	25(oh)d	76-83	interleukin 1 alpha	Homo sapiens	142-150
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	interleukin 1 alpha	Homo sapiens	137-145
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	kaempferol	46-56	interleukin 1 alpha	Homo sapiens	137-145
34162132-7	2021	Our results show that safinamide inhibited the expression of pro-inflammatory cytokines such as IL-1alpha, TNF-alpha, and IL-6.	safinamide	22-32	interleukin 1 alpha	Homo sapiens	96-105
34143493-5	2021	IL-1beta-induced Ca2+ and Ba2+ influxes in the cells were negated by pharmacological inhibition and siRNA-mediated knockdown of TRPA1 channels.	N-methyl-valyl-amiclenomycin	26-30	interleukin 1 alpha	Homo sapiens	0-8
34446131-11	2021	Furthermore, the RP1R3V6/AMO92a complex decreased the TNF-alpha and interleukin-1beta (IL-1beta) levels more efficiently than did the PEI25k/AMO92a and R3V6/AMO92a complexes, decreasing the damage in the lungs.	amo92a	25-31	interleukin 1 alpha	Homo sapiens	87-95
34162145-1	2021	Following induction of inflammation, the nuclear factor kappa B (NF-kappaB) in activated macrophages induces the transcription of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and cyclooxygenase (COX), an inflammatory enzyme implicated in the synthesis of prostaglandins (PGs).	Prostaglandins	338-352	interleukin 1 alpha	Homo sapiens	225-233
34185112-6	2021	RESULTS: Compared with the high glucose group, the proliferation rate, migration rate, and the expression of alpha-SMA, bcl-2, TLR4, NF-kappaB, TNF-alpha, IL-6, IL- and IL-1 were significantly decreased in the high glucose + MSC-Exo-miR-26a mimics group, while the apoptosis rate and the expression of miR-26a, cleaved-caspase 3, cleaved-caspase 9 and Bax were significantly increased.	Glucose	215-222	interleukin 1 alpha	Homo sapiens	161-173
34211022-4	2021	We show that the small molecule inhibitors MG132 (a 26S proteasome inhibitor used to block NF-kappaB signaling) and U0126 (a MAPK Kinase inhibitor used to block CCAAT-enhancer-binding proteins C/EBP) successfully block IL-1beta and TNF-alpha mRNA expression.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	43-48	interleukin 1 alpha	Homo sapiens	219-227
34634848-1	2021	OBJECTIVES: The primary objective of this study was to define the relationship between vitamin D levels and interleukins (IL) 1beta and 6 as inflammatory markers in a healthy population.	Vitamin D	87-96	interleukin 1 alpha	Homo sapiens	108-131
34211022-4	2021	We show that the small molecule inhibitors MG132 (a 26S proteasome inhibitor used to block NF-kappaB signaling) and U0126 (a MAPK Kinase inhibitor used to block CCAAT-enhancer-binding proteins C/EBP) successfully block IL-1beta and TNF-alpha mRNA expression.	U 0126	116-121	interleukin 1 alpha	Homo sapiens	219-227
34164963-11	2021	CONCLUSION: We demonstrated that inhibition of miRNA-495 alleviates IL-1beta-induced inflammatory responses in chondrocytes by rescuing SOX9 expression.	mirna-495	47-56	interleukin 1 alpha	Homo sapiens	68-76
34187428-11	2021	Moreover, the regression of tumors in mice that received PV-10 in combination with gemcitabine was associated with the depletion of splenic CD11b+Gr-1+ cells and increases in damage associated molecular patterns HMGB1, S100A8, and IL-1alpha.	pv-10	57-62	interleukin 1 alpha	Homo sapiens	231-240
34187428-11	2021	Moreover, the regression of tumors in mice that received PV-10 in combination with gemcitabine was associated with the depletion of splenic CD11b+Gr-1+ cells and increases in damage associated molecular patterns HMGB1, S100A8, and IL-1alpha.	gemcitabine	83-94	interleukin 1 alpha	Homo sapiens	231-240
34276328-6	2021	It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18.	Acetylcholine	56-69	interleukin 1 alpha	Homo sapiens	291-299
34276328-6	2021	It has been proposed that vagal efferent fibers release acetylcholine (Ach), which can interact with alpha7-subunit-containing nicotinic receptors expressed by tissue macrophages and other immune cells to rapidly inhibit the synthesis/release of pro-inflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and IL-18.	Acetylcholine	71-74	interleukin 1 alpha	Homo sapiens	291-299
34262937-13	2021	In addition, silencing STUB1 increased the apoptosis of HK-2 cells and the proinflammatory cytokine production of IL6, TNFalpha, and IL1beta induced by cisplatin.	Cisplatin	152-161	interleukin 1 alpha	Homo sapiens	133-140
34209843-3	2021	The obtained compounds were screened in vitro to test their ability to inhibit NLRP3-dependent pyroptosis and IL-1beta release in PMA-differentiated THP-1 cells stimulated with LPS/ATP.	Adenosine Triphosphate	181-184	interleukin 1 alpha	Homo sapiens	110-118
34209843-5	2021	From this screening, compounds 9, 13 and 18, able to concentration-dependently inhibit IL-1beta release in LPS/ATP-stimulated human macrophages, emerged as the most promising NLRP3 inhibitors of the series.	Adenosine Triphosphate	111-114	interleukin 1 alpha	Homo sapiens	87-95
34172047-11	2021	RESULTS: ACRH, QRF, and BQ exerted concentration-independent antiproliferative effects on VEGF-induced HUVECs and IL-1beta-induced HFLS-RA, with IC50 values at 1.09 +- 0.18, 3.85 +- 0.26, and 1.34 +- 0.16 mug/mL in HUVECs; and 3.60 +- 1.38, 4.47 +- 0.34, and 1.09 +- 0.09 mug/mL in HFLS-RA, respectively.	bulaquine	24-26	interleukin 1 alpha	Homo sapiens	114-122
34203170-5	2021	We also observed the secretion of inflammatory cytokine, IL-1beta, by the activation of NLRC4 with FLA-AA.	fla-aa	99-105	interleukin 1 alpha	Homo sapiens	57-65
34251369-4	2021	Polyanhydride nanoparticle (NP)-based delivery of IL-1alpha would represent an effective approach in this context since this may allow for a slow and controlled release of IL-1alpha systemically while reducing toxic side effects.	Polyanhydrides	0-13	interleukin 1 alpha	Homo sapiens	50-59
34251369-4	2021	Polyanhydride nanoparticle (NP)-based delivery of IL-1alpha would represent an effective approach in this context since this may allow for a slow and controlled release of IL-1alpha systemically while reducing toxic side effects.	Polyanhydrides	0-13	interleukin 1 alpha	Homo sapiens	172-181
34172047-14	2021	ACRH and BQ, but not QRF, significantly enhanced the apoptosis of IL-1beta-induced HFLS-RA elicited at their highest concentration (5 mug/mL) (P < 0.05).	acrh	0-4	interleukin 1 alpha	Homo sapiens	66-74
34172047-14	2021	ACRH and BQ, but not QRF, significantly enhanced the apoptosis of IL-1beta-induced HFLS-RA elicited at their highest concentration (5 mug/mL) (P < 0.05).	bulaquine	9-11	interleukin 1 alpha	Homo sapiens	66-74
34172047-14	2021	ACRH and BQ, but not QRF, significantly enhanced the apoptosis of IL-1beta-induced HFLS-RA elicited at their highest concentration (5 mug/mL) (P < 0.05).	hfls-ra	83-90	interleukin 1 alpha	Homo sapiens	66-74
34171934-5	2022	Platelets release IL-1beta within minutes in response to adenosine diphosphate (ADP), collagen, and thrombin receptor agonists, but not in response to conventional NLRP3 inflammasome agonists-lipopolysaccharide and adenosine triphosphate.	Adenosine	57-66	interleukin 1 alpha	Homo sapiens	18-26
34171934-5	2022	Platelets release IL-1beta within minutes in response to adenosine diphosphate (ADP), collagen, and thrombin receptor agonists, but not in response to conventional NLRP3 inflammasome agonists-lipopolysaccharide and adenosine triphosphate.	Adenosine Diphosphate	80-83	interleukin 1 alpha	Homo sapiens	18-26
34166397-4	2021	AKIP1 knockdown reversed the effect of forskolin, such that its addition inhibited IL-1beta-induced COX-2 mRNA expression and reduced the IL-1beta-induced increase in nuclear levels of p65 and c-jun.	Colforsin	39-48	interleukin 1 alpha	Homo sapiens	138-146
34166397-2	2021	Here, we have extended these observations, using primary myometrial cell cultures to show that the cAMP agonist, forskolin, enhances IL-1beta-driven COX-2 expression.	Colforsin	113-122	interleukin 1 alpha	Homo sapiens	133-141
34166397-4	2021	AKIP1 knockdown reversed the effect of forskolin, such that its addition inhibited IL-1beta-induced COX-2 mRNA expression and reduced the IL-1beta-induced increase in nuclear levels of p65 and c-jun.	Colforsin	39-48	interleukin 1 alpha	Homo sapiens	83-91
34160339-0	2021	Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1beta-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.	mir-142-5p	128-138	interleukin 1 alpha	Homo sapiens	65-73
34160339-11	2021	MiR-142-5p inhibitor offset exosomal PCGEM1 knockdown-mediated effects on the apoptosis and cartilage matrix degradation of IL-1beta-induced chondrocytes.	mir-142-5p	0-10	interleukin 1 alpha	Homo sapiens	124-132
34160339-12	2021	RUNX2 overexpression counteracted the suppressive effect of miR-142-5p mimic on apoptosis and cartilage matrix degradation of IL-1beta-induced chondrocytes.Conclusion: Exosomal PCGEM1 from OA-FLSs facilitated IL-1beta-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR-142-5p and upregulating RUNX2, which offered new insights into the pathogenesis of OA.	mir-142-5p	60-70	interleukin 1 alpha	Homo sapiens	209-217
34160339-12	2021	RUNX2 overexpression counteracted the suppressive effect of miR-142-5p mimic on apoptosis and cartilage matrix degradation of IL-1beta-induced chondrocytes.Conclusion: Exosomal PCGEM1 from OA-FLSs facilitated IL-1beta-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR-142-5p and upregulating RUNX2, which offered new insights into the pathogenesis of OA.	mir-142-5p	301-311	interleukin 1 alpha	Homo sapiens	209-217
34201817-5	2021	Using SARS-CoV-2 peptide/IL-1beta- or LPS-activated human PBMCs and an inflammatory intestinal Caco-2/HT29-MTX co-culture, Salix extracts, and ASA concentration-dependently suppressed prostaglandin E2 (PGE2), a principal mediator of inflammation.	Dinoprostone	184-200	interleukin 1 alpha	Homo sapiens	25-33
34201817-5	2021	Using SARS-CoV-2 peptide/IL-1beta- or LPS-activated human PBMCs and an inflammatory intestinal Caco-2/HT29-MTX co-culture, Salix extracts, and ASA concentration-dependently suppressed prostaglandin E2 (PGE2), a principal mediator of inflammation.	Dinoprostone	202-206	interleukin 1 alpha	Homo sapiens	25-33
34257799-14	2021	The concentrations of IL-1beta, IL-6, and IL-8 in the plasma were all decreased upon ZnO administration.	Zinc Oxide	85-88	interleukin 1 alpha	Homo sapiens	22-30
34188474-11	2021	Iron concentration was positively correlated with IL-1beta concentration in the PD-EDS group.	Iron	0-4	interleukin 1 alpha	Homo sapiens	50-58
34206447-0	2021	MMP-9 and IL-1beta as Targets for Diatoxanthin and Related Microalgal Pigments: Potential Chemopreventive and Photoprotective Agents.	diatoxanthin	34-46	interleukin 1 alpha	Homo sapiens	10-18
34206447-8	2021	Diatoxanthin resulted the best performing pigment in lowering MMP-9 levels and was able to strongly lower IL-1beta.	diatoxanthin	0-12	interleukin 1 alpha	Homo sapiens	106-114
34205482-4	2021	Thereby, inhibition of EGFR transactivation by the Src inhibitor PP1 or direct EGFR inhibition by the EGFR tyrosine kinase inhibitor (TKI) erlotinib led to a reduction of IL-1beta-induced TF expression and to a suppression of p42/44 MAPK and EGFR activation, while IL-1beta-induced p38 MAPK and JNK activation remained unchanged.	Erlotinib Hydrochloride	139-148	interleukin 1 alpha	Homo sapiens	171-179
34205482-5	2021	A knockdown of EGFR by siRNA was associated with decreased IL-1beta-mediated p42/44 MAPK activation, which was no longer inhibitable by erlotinib.	Erlotinib Hydrochloride	136-145	interleukin 1 alpha	Homo sapiens	59-67
34205482-6	2021	Concentration-dependent inhibition of IL-1beta-induced TF expression was also observed in the presence of gefitinib and afatinib, two other EGFR TKIs.	Gefitinib	106-115	interleukin 1 alpha	Homo sapiens	38-46
34205482-6	2021	Concentration-dependent inhibition of IL-1beta-induced TF expression was also observed in the presence of gefitinib and afatinib, two other EGFR TKIs.	Afatinib	120-128	interleukin 1 alpha	Homo sapiens	38-46
34249610-18	2021	Conclusion: miR-133a-5p was upregulated by IL-1beta to aggravate intervertebral disc degeneration via sponging FBXO6.	mir-133a-5p	12-23	interleukin 1 alpha	Homo sapiens	43-51
34207168-4	2021	The effect of xanthone 1-conditioned THP-1 human macrophage supernatants on the metabolic viability of cervical and prostate cancer cell lines was determined along with its interference with cytokine expression characteristic of M1 profile (IL-1 <= beta; TNF-alpha) or M2 profile (IL-10; TGF-beta) (PCR and ELISA).	xanthone	14-22	interleukin 1 alpha	Homo sapiens	241-253
34145895-8	2021	The increased malondialdehyde (MDA) and Interleukin-1beta (IL-1beta), and decreased superoxide dismutase (SOD) were observed in the DOX group, while tVNS significantly prevented these changes.	Doxorubicin	132-135	interleukin 1 alpha	Homo sapiens	59-67
34145895-8	2021	The increased malondialdehyde (MDA) and Interleukin-1beta (IL-1beta), and decreased superoxide dismutase (SOD) were observed in the DOX group, while tVNS significantly prevented these changes.	tvns	149-153	interleukin 1 alpha	Homo sapiens	59-67
34198548-3	2021	Macrophage-specific deletion of Glucose Transporter 1 (GLUT1) significantly reduced tumor burden, which was accompanied by increased Natural Killer and CD8+ T cell activity and suppression of the NLRP3-IL1beta inflammasome axis.	Glucose	32-39	interleukin 1 alpha	Homo sapiens	202-209
34147675-8	2022	Cholesterol accumulation in cardiac muscle cells can result in a significant increase in the levels of BNP, inflammatory factors (IL-1beta, IL-6, TNF-alpha and CCL-2) in cardiac muscle cells, which exacerbates cardiomyocyte damage.	Cholesterol	0-11	interleukin 1 alpha	Homo sapiens	130-138
34220507-8	2021	Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma.	myricetin	39-48	interleukin 1 alpha	Homo sapiens	214-223
34220507-8	2021	Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma.	Bleomycin	70-79	interleukin 1 alpha	Homo sapiens	214-223
34208683-5	2021	As an anti-inflammatory compound, NAC can reduce levels of tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL-6 and IL-1beta) by suppressing the activity of nuclear factor kappa B (NF-kappaB).	Acetylcysteine	34-37	interleukin 1 alpha	Homo sapiens	126-134
34208638-5	2021	SCFA down-attenuated host pro-inflammatory IL-1beta, IL-6, and TNFalpha response predominantly through the TLR4 pathway, whereas MCFA augmented inflammation through TLR2.	Fatty Acids, Volatile	0-4	interleukin 1 alpha	Homo sapiens	43-51
34203721-8	2021	IL1A expression was reduced by UO126.	U 0126	31-36	interleukin 1 alpha	Homo sapiens	0-4
34203721-12	2021	Taken together, ETL inhibited the MEK/ERK and PI3K/AKT signaling pathway and suppressing the lung metastasis of TNBC cells through downregulation of IL1A.	etl	16-19	interleukin 1 alpha	Homo sapiens	149-153
34120620-9	2021	DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-alpha and IL-1beta.	Doxorubicin	0-3	interleukin 1 alpha	Homo sapiens	270-278
34199192-6	2021	Tyrosinase was revealed as a key player in caffeine"s mechanisms of action, suggesting a crucial role in immunomodulation through the reduction in IL-1beta, IP-10, MIP-1alpha, MIP-1beta and RANTES secretion onto MICs conditioned media.	Caffeine	43-51	interleukin 1 alpha	Homo sapiens	147-155
34120620-9	2021	DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-alpha and IL-1beta.	Samarium	18-20	interleukin 1 alpha	Homo sapiens	270-278
34199278-4	2021	Here, we explored whether the mRNA expression of IL-1beta and IL-6, induced by the combination of DON and PCV2, would depend on the MAPK signaling pathway.	deoxynivalenol	98-101	interleukin 1 alpha	Homo sapiens	49-57
34199278-7	2021	The results showed that PK-15 cells treated with DON or PCV2 induced the mRNA expression of IL-1beta and IL-6 in a time- and dose-dependent manner.	deoxynivalenol	49-52	interleukin 1 alpha	Homo sapiens	92-100
34177582-27	2021	Besides, angelicin can also protect and maintain M2 polarization in the presence of LPS/IFN-gamma, and subsequently downregulate the expression of inflammatory mediators such as IL-1beta and TNF-alpha.	angelicin	9-18	interleukin 1 alpha	Homo sapiens	178-186
34199278-8	2021	The combination of DON and PCV2 has an additive effect on inducing the mRNA expression of IL-1beta and IL-6.	deoxynivalenol	19-22	interleukin 1 alpha	Homo sapiens	90-98
34199278-9	2021	Additionally, both DON and PCV2 could induce the mRNA expression of IL-1beta and IL-6 via the ERK and the p38 MAPK signal pathways, while PCV2 could induce it via the JNK signal pathway.	deoxynivalenol	19-22	interleukin 1 alpha	Homo sapiens	68-76
34199278-10	2021	Taken together, our results suggest that MAPKs play a contributory role in IL-1beta and IL-6 mRNA expression when induced by both DON and PCV2.	deoxynivalenol	130-133	interleukin 1 alpha	Homo sapiens	75-83
34116684-0	2021	MiR-24-3p attenuates IL-1beta-induced chondrocyte injury associated with osteoarthritis by targeting BCL2L12.	mir-24-3p	0-9	interleukin 1 alpha	Homo sapiens	21-29
34116684-8	2021	RESULTS: We first observed that miR-24-3p expression level was lower in the OA cases than in the control patients and IL-1beta decreased the expression of miR-24-3p in the chondrocyte CHON-001.	mir-24-3p	32-41	interleukin 1 alpha	Homo sapiens	118-126
34116684-9	2021	Functionally, overexpression of miR-24-3p significantly attenuated IL-1beta-induced chondrocyte injury, as reflected by increased cell viability, decreased caspase-3 activity, and pro-inflammatory cytokines (TNF-alpha and IL-18).	mir-24-3p	32-41	interleukin 1 alpha	Homo sapiens	67-75
34116684-12	2021	BCL2L12 knockdown imitated, while overexpression significantly abrogated the protective effects of miR-24-3p against IL-1beta-induced chondrocyte injury.	mir-24-3p	99-108	interleukin 1 alpha	Homo sapiens	117-125
34486693-9	2021	Meanwhile, Itaconate inhibited a higher amount of IL-1beta and TNF-alpha than tBHQ.	itaconic acid	11-20	interleukin 1 alpha	Homo sapiens	50-58
34486693-9	2021	Meanwhile, Itaconate inhibited a higher amount of IL-1beta and TNF-alpha than tBHQ.	2-tert-butylhydroquinone	78-82	interleukin 1 alpha	Homo sapiens	50-58
34163481-6	2021	In addition, the combination of metformin with other drugs that improve the function of macrophages (such as SGLT2 inhibitors, statins and IL-1beta inhibitors/monoclonal antibodies) may further enhance the pleiotropic therapeutic potential of metformin in conditions such as atherosclerosis, obesity, cancer, dementia and aging.	Metformin	32-41	interleukin 1 alpha	Homo sapiens	139-147
34108550-7	2021	Significant positive correlations between triglyceride levels and hs-CRP, IL-1beta, and IFN-gamma concentrations, and between Apo B and IFN-gamma levels were observed 6 months after bariatric and metabolic surgery.	Triglycerides	42-54	interleukin 1 alpha	Homo sapiens	74-82
34164408-6	2021	In contrast, the HMGB1-mediated expression of HLA-DR, CD40, and CD86 on dendritic cells and production of IL-1beta, IL-6, and TNF-alpha were reduced by rapamycin.	Sirolimus	152-161	interleukin 1 alpha	Homo sapiens	106-114
34090451-2	2021	The aim of this study was to investigate the effects of betaine supplementation on tumor necrosis factor alpha (TNF-alpha), interleukins-1 beta (IL-1beta), - 6 (IL-6) and the complete blood cell (CBC) count in professional youth soccer players during a competitive season.	Betaine	56-63	interleukin 1 alpha	Homo sapiens	145-153
34075738-7	2021	Our data confirmed that Ononin could alleviate TNF-alpha-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-kappaB and MAPK pathways.	calycosin-7-O-beta-D-glucoside	24-30	interleukin 1 alpha	Homo sapiens	201-209
34078403-8	2021	IL-1beta, LPS or H2O2 treatment increased the expression of IL24 in PBMCs and LPMCs.	Hydrogen Peroxide	17-21	interleukin 1 alpha	Homo sapiens	0-8
34078931-6	2021	As the results, we found that treatment with recombinant human His6-GABARAP protein promoted cell proliferation, inhibited apoptosis, and reduced ROS generation by increasing autophagic activity, particularly when co-cultured with IL-1beta.	ros	146-149	interleukin 1 alpha	Homo sapiens	231-239
34350239-11	2021	Results: We observed decreased cell viability, increased apoptosis, and increased inflammatory factors such as IL-1beta, IL-6, and TNF-alpha in the MPP+ induced PD model.	mangion-purified polysaccharide (Candida albicans)	148-151	interleukin 1 alpha	Homo sapiens	111-119
34350239-12	2021	We also found decreased DA secretion and TH expression, as well as increased NLRP3, caspase-1, ASC, IL-1alpha, and IL-18 expression in the MPP+ induced PD model.	mangion-purified polysaccharide (Candida albicans)	139-143	interleukin 1 alpha	Homo sapiens	100-109
34077680-4	2021	ZMO exhibited anti-inflammatory capacity by inhibiting the formation of pro-inflammatory markers such as nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1beta, IL-6, and monocyte chemoattractant protein-1 in LPS-treated macrophages.	S-[2-({n-[(2s)-2-Hydroxy-3,3-Dimethyl-4-(Phosphonooxy)butanoyl]-Beta-Alanyl}amino)ethyl] (9z)-Hexadec-9-Enethioate	0-3	interleukin 1 alpha	Homo sapiens	170-192
34076141-7	2021	Moreover, 0.5% CrMFSOL attenuated myeloperoxidase (MPO) activity and also stimulated the release of interleukin (IL)-1beta and IL-10 after 3 days of treatment.	crmfsol	15-22	interleukin 1 alpha	Homo sapiens	100-122
34072916-5	2021	However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS.	Auranofin	9-18	interleukin 1 alpha	Homo sapiens	137-159
34072916-5	2021	However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS.	Palmitic Acid	246-248	interleukin 1 alpha	Homo sapiens	137-159
34072916-6	2021	Moreover, the expression of inducible NO synthase, IL-1beta, and IL-6 mRNA and protein levels increased by PA and LPS were reduced by auranofin.	Palmitic Acid	107-109	interleukin 1 alpha	Homo sapiens	51-59
34072916-6	2021	Moreover, the expression of inducible NO synthase, IL-1beta, and IL-6 mRNA and protein levels increased by PA and LPS were reduced by auranofin.	Auranofin	134-143	interleukin 1 alpha	Homo sapiens	51-59
34201243-6	2021	Quantitative RT-PCR analysis revealed that irinotecan at 15 microM was able to amplify the antiviral response (i.e., interferon-stimulated gene expression) of HSF exposed to PIC and reduce the expression of pro-inflammatory genes (CXCL8, IL-6 and COX-2) upon IL-1beta treatment.	Irinotecan	43-53	interleukin 1 alpha	Homo sapiens	259-267
34099830-1	2021	Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1beta secretion and subsequent development of inflammation and organ fibrosis.	ibrutinib	30-39	interleukin 1 alpha	Homo sapiens	202-210
34204056-3	2021	The ellagitannins (1 and 2) were evaluated on its inhibitory activities of the enzyme 5alpha-reductase and tumor necrosis factor (TNF)-alpha, its interleukin (IL)-1beta, IL-6, and IL-8 production, and its anti-proliferation and apoptosis induction in prostate cells that show hypertrophy (RWPE-1 cell).	Hydrolyzable Tannins	4-17	interleukin 1 alpha	Homo sapiens	146-168
34204067-4	2021	In the present study, we investigated the propensity of hydroquinone to induce the secretion of interleukin (IL)-1beta and IL-18.	hydroquinone	56-68	interleukin 1 alpha	Homo sapiens	96-118
34204067-9	2021	Cytoplasmic NLRP3 levels increased after the hydroquinone treatment of IL-1alpha-primed RPE cells, but IL-18 was equally released from primed and nonprimed cells.	hydroquinone	45-57	interleukin 1 alpha	Homo sapiens	71-80
34150748-8	2021	Neutralization of IL-1beta attenuated TAM maturation, proliferation, and migration induced by the conditioned medium from IFI16-overexpressing PAAD cells.	tam	38-41	interleukin 1 alpha	Homo sapiens	18-26
34349888-2	2021	ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome.	Reactive Oxygen Species	0-3	interleukin 1 alpha	Homo sapiens	58-76
34163481-6	2021	In addition, the combination of metformin with other drugs that improve the function of macrophages (such as SGLT2 inhibitors, statins and IL-1beta inhibitors/monoclonal antibodies) may further enhance the pleiotropic therapeutic potential of metformin in conditions such as atherosclerosis, obesity, cancer, dementia and aging.	Metformin	243-252	interleukin 1 alpha	Homo sapiens	139-147
34093539-5	2021	RDV also inhibited other pro-inflammatory genes including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-12, IL-1beta, and interferon-beta (IFN-beta), leading to the reduction of inflammatory factors release.	remdesivir	0-3	interleukin 1 alpha	Homo sapiens	128-136
34124036-7	2021	Results: TEM, NTA, and western blotting showed that exosomes were successfully isolated, and PKH67 staining showed that exosomes could be taken up by IL-1beta-induced chondrocytes.	PKH67	93-98	interleukin 1 alpha	Homo sapiens	150-158
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Nitric Oxide	162-174	interleukin 1 alpha	Homo sapiens	70-78
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Dinoprostone	184-200	interleukin 1 alpha	Homo sapiens	70-78
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Dinoprostone	202-206	interleukin 1 alpha	Homo sapiens	70-78
34073895-4	2021	Pretreatment with 20 muM artemisinin weakened LPS-induced inflammatory damage in pMECs and decreased mRNA expression abundance and the content of inflammatory factors (IL-1beta, IL-6, and TNF-alpha) in pMECs (p < 0.05).	artemisinin	25-36	interleukin 1 alpha	Homo sapiens	168-176
34063751-0	2021	Omega-3 PUFAs Suppress IL-1beta-Induced Hyperactivity of Immunoproteasomes in Astrocytes.	omega-3 pufas	0-13	interleukin 1 alpha	Homo sapiens	23-31
34070506-6	2021	In a model of bleomycin-induced pulmonary fibrosis, pHD decreased the level of tissue IL-1beta and TGF-beta, prevented the infiltration of the lung parenchyma by CD16+ cells, and reduced perivascular and peribronchial inflammation.	Bleomycin	14-23	interleukin 1 alpha	Homo sapiens	86-94
34069836-0	2021	Antioxidant Ascorbic Acid Modulates NLRP3 Inflammasome in LPS-G Treated Oral Stem Cells through NFkappaB/Caspase-1/IL-1beta Pathway.	Ascorbic Acid	12-25	interleukin 1 alpha	Homo sapiens	115-123
34093519-6	2021	The blockade of TNFalpha and IL1beta with adalimumab and anti-IL1beta antibody respectively, as well as the application of focal adhesion kinase (FAK) inhibitor, effectively ameliorated endothelial activation induced by CAR-T, tumor cells, and myeloid cells.	car-t	220-225	interleukin 1 alpha	Homo sapiens	29-36
34093519-6	2021	The blockade of TNFalpha and IL1beta with adalimumab and anti-IL1beta antibody respectively, as well as the application of focal adhesion kinase (FAK) inhibitor, effectively ameliorated endothelial activation induced by CAR-T, tumor cells, and myeloid cells.	car-t	220-225	interleukin 1 alpha	Homo sapiens	62-69
34093519-7	2021	Moreover, adalimumab and anti-IL1beta antibody exerted synergistic effect on the prevention of endothelial activation induced by CAR-T, tumor cells, and myeloid cells.	car-t	129-134	interleukin 1 alpha	Homo sapiens	30-37
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Glutathione	104-107	interleukin 1 alpha	Homo sapiens	13-21
34079554-9	2021	We also observed spontaneous and fMPL-induced activation of PMNs from the patients after transmigration through inserts as seen by the increased expression of CD11b and intracellular expression of IL-1beta.	fmpl	33-37	interleukin 1 alpha	Homo sapiens	197-205
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Cysteine	56-64	interleukin 1 alpha	Homo sapiens	13-21
34084773-12	2021	Finally, we observed increased IL-1beta and IL-18 levels in the dialysate of incident PD patients, showing a positive correlation with PGE2.	Dinoprostone	135-139	interleukin 1 alpha	Homo sapiens	31-39
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Glutathione Disulfide	109-113	interleukin 1 alpha	Homo sapiens	13-21
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Glutamic Acid	69-82	interleukin 1 alpha	Homo sapiens	13-21
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Glutathione	91-102	interleukin 1 alpha	Homo sapiens	13-21
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	cys-gsh disulfide	115-132	interleukin 1 alpha	Homo sapiens	13-21
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	met-sulfoxide	135-148	interleukin 1 alpha	Homo sapiens	13-21
34068182-8	2021	At 3 h after IL-1beta treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated.	Pyrrolidonecarboxylic Acid	150-162	interleukin 1 alpha	Homo sapiens	13-21
34068523-7	2021	NTS and MSM also inhibited LPS-induced nuclear accumulation and binding of NF-kappaB to proinflammatory cytokines COX-2, IL-1beta, and IL-6.	nts	0-3	interleukin 1 alpha	Homo sapiens	121-129
34064821-0	2021	Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1beta Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation.	Leukotrienes	0-11	interleukin 1 alpha	Homo sapiens	85-93
34064821-6	2021	The enzymes 5-lipoxygenase and 12-lipoxygenase, which catalyze the synthesis of BLT1/2 ligands (LTB4, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), and 12-hydroxyheptadecatreinoic acid (12-HHT)), were also critically associated with the stimulation of NLRP3 and IL-1beta synthesis.	Leukotriene B4	96-100	interleukin 1 alpha	Homo sapiens	265-273
34064821-6	2021	The enzymes 5-lipoxygenase and 12-lipoxygenase, which catalyze the synthesis of BLT1/2 ligands (LTB4, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), and 12-hydroxyheptadecatreinoic acid (12-HHT)), were also critically associated with the stimulation of NLRP3 and IL-1beta synthesis.	12-hydroxyheptadecatreinoic acid	155-187	interleukin 1 alpha	Homo sapiens	265-273
34064821-6	2021	The enzymes 5-lipoxygenase and 12-lipoxygenase, which catalyze the synthesis of BLT1/2 ligands (LTB4, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), and 12-hydroxyheptadecatreinoic acid (12-HHT)), were also critically associated with the stimulation of NLRP3 and IL-1beta synthesis.	12-hydroxy-5,8,10-heptadecatrienoic acid	189-195	interleukin 1 alpha	Homo sapiens	265-273
34064830-6	2021	alpha-Humulene also reduced the expression levels of cytokine genes such as interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF) by downregulating nuclear factor-kappaB (NF-kappaB) nuclear translocation.	humulene	0-14	interleukin 1 alpha	Homo sapiens	76-98
34064989-0	2021	Empagliflozin Inhibits IL-1beta-Mediated Inflammatory Response in Human Proximal Tubular Cells.	empagliflozin	0-13	interleukin 1 alpha	Homo sapiens	23-31
34064989-2	2021	We recently presented first evidence for anti-inflammatory potential of empagliflozin (Empa) under normoglycemic conditions in human proximal tubular cells (HPTC) by demonstrating Empa-mediated inhibition of IL-1beta-induced MCP-1/CCL2 and ET-1 expression on the mRNA and protein level.	empagliflozin	72-85	interleukin 1 alpha	Homo sapiens	208-216
34064989-2	2021	We recently presented first evidence for anti-inflammatory potential of empagliflozin (Empa) under normoglycemic conditions in human proximal tubular cells (HPTC) by demonstrating Empa-mediated inhibition of IL-1beta-induced MCP-1/CCL2 and ET-1 expression on the mRNA and protein level.	empagliflozin	180-184	interleukin 1 alpha	Homo sapiens	208-216
34064989-4	2021	Using microarray-hybridization analysis, 19 inflammatory response genes out of >30.000 human genes presented a consistent expression pattern, that is, inhibition of IL-1beta (10 ng/mL)-stimulated gene expression by Empa (500 nM), in both HK-2 and RPTEC/TERT1 cells.	empagliflozin	215-219	interleukin 1 alpha	Homo sapiens	165-173
34062977-6	2021	Using our existing protocol, inflammasome activation was induced in IL-1alpha-primed ARPE-19 cells with the proteasome and autophagy inhibitors MG-132 and bafilomycin A1, respectively.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	144-150	interleukin 1 alpha	Homo sapiens	68-77
34066976-0	2021	The Blockade of Tumoral IL1beta-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation.	cafestol palmitate	146-149	interleukin 1 alpha	Homo sapiens	24-31
34066976-8	2021	IL1beta-stimulated-NCF-CM induces migration and differential sensitivity to oxaliplatin in colorectal tumor cells.	Oxaliplatin	76-87	interleukin 1 alpha	Homo sapiens	0-7
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Salts	86-90	interleukin 1 alpha	Homo sapiens	44-52
34066647-5	2021	Our results indicated that ethyl pyruvate significantly suppressed LPS and ATP-induced NLRP3 inflammasome activation, decreased active caspase-1 level, secretion of IL-1beta and IL-18 cytokines, and reduced the level of pyroptotic cell death resulting from inflammasome activation.	ethyl pyruvate	27-41	interleukin 1 alpha	Homo sapiens	165-173
34066647-5	2021	Our results indicated that ethyl pyruvate significantly suppressed LPS and ATP-induced NLRP3 inflammasome activation, decreased active caspase-1 level, secretion of IL-1beta and IL-18 cytokines, and reduced the level of pyroptotic cell death resulting from inflammasome activation.	Adenosine Triphosphate	75-78	interleukin 1 alpha	Homo sapiens	165-173
34064310-11	2021	In the peritoneal fluid, Hidrox  treatment reduced interleukin (IL)-1beta, IL2, IL6, tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial grow factor (VEGF) levels increased by the disease.	hidrox	25-31	interleukin 1 alpha	Homo sapiens	51-73
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Thioguanine	99-101	interleukin 1 alpha	Homo sapiens	44-52
34062977-6	2021	Using our existing protocol, inflammasome activation was induced in IL-1alpha-primed ARPE-19 cells with the proteasome and autophagy inhibitors MG-132 and bafilomycin A1, respectively.	bafilomycin A1	155-169	interleukin 1 alpha	Homo sapiens	68-77
34062977-10	2021	Our findings show that TAS-116 could prevent the activation of caspase-1, subsequently reducing the release of mature IL-1beta.	TAS-116	23-30	interleukin 1 alpha	Homo sapiens	118-126
34585876-15	2021	In patients with peri-implant mucositis, increasing peri-implant PD and IL-1beta levels directly correlated with increased PISF suPAR (p < 0.001) and galectin-1 (p < 0.05) levels.	pisf supar	123-133	interleukin 1 alpha	Homo sapiens	72-80
34164484-11	2021	Further, ERK1/2 inhibition by AZD0364 prevented IL-1beta, IL-6, IL-12, and CDK5 expression, as well as activation of ERK1/2 and phosphorylation of PPARgamma, induced by LPS.	N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide	30-37	interleukin 1 alpha	Homo sapiens	48-56
34602387-5	2021	The mRNA expression of TNF-alpha, IL-8 and IL-1beta in the azithromycin group was lower than that in the control group (P<0.05).	Azithromycin	59-71	interleukin 1 alpha	Homo sapiens	43-51
34092579-0	2021	The effect of IL-1beta on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells.	Tamoxifen	46-55	interleukin 1 alpha	Homo sapiens	14-22
34092579-2	2021	OBJECTIVES: We aimed to evaluate the effect of cytokine interleukin-1beta (IL-1beta) as a key mediator of inflammation on multidrug resistance associated protein 2 (MRP2) expression and tamoxifen toxicity in estrogen receptor positive (ER+) MCF-7 breast cancer cells.	Tamoxifen	186-195	interleukin 1 alpha	Homo sapiens	75-83
34981467-11	2021	Moreover, IL-1alpha showed a decreasing trend after curcuminoid supplementation compared to placebo (p = 0.077).	Diarylheptanoids	52-63	interleukin 1 alpha	Homo sapiens	10-19
34522469-11	2021	SUA was also significantly associated with gut barrier dysfunction markers, LBP and LPS, in group 2, SUA and LBP predicted IL-1beta significantly in group 2.	sua	0-3	interleukin 1 alpha	Homo sapiens	123-131
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	Tamoxifen	36-45	interleukin 1 alpha	Homo sapiens	102-110
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	Estradiol	118-134	interleukin 1 alpha	Homo sapiens	24-32
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	Estradiol	136-138	interleukin 1 alpha	Homo sapiens	24-32
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	Estradiol	136-138	interleukin 1 alpha	Homo sapiens	102-110
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	monooxyethylene trimethylolpropane tristearate	157-160	interleukin 1 alpha	Homo sapiens	24-32
34092579-3	2021	METHODS: The effects of IL-1beta on tamoxifen toxicity following 20-day treatment of MCF-7 cells with IL-1beta and/or 17beta-estradiol (E2) were measured by MTT assay.	monooxyethylene trimethylolpropane tristearate	157-160	interleukin 1 alpha	Homo sapiens	102-110
34092579-5	2021	RESULTS: Treatment of breast cancer cells with IL-1beta+ E2 decreased the sensitivity to 4-OH tamoxifen compared to both E2-treated and untreated cells.	Tamoxifen	94-103	interleukin 1 alpha	Homo sapiens	47-55
34092579-8	2021	CONCLUSION: Increased expression of mRNA and protein level of MRP2 following 20-day treatment of MCF-7 cells with IL-1beta + E2 might be a possible elucidation for the increased tamoxifen resistance which was observed in these cells.	Tamoxifen	178-187	interleukin 1 alpha	Homo sapiens	114-122
34151811-4	2021	METHODS: 200 and 400muM PA-conjugated BSA were applied to SH-SY5Y and HMC3 cells for 24 h. For FcgammaR blockage experiment, both cells were exposed to FcgammaR blocker before receiving of 200 and 400muM of PA-conjugated BSA for 24 h. RESULTS: PA significantly increased AD-related proteins, including Abeta and BACE1, as well as increasing TNFalpha, IL-1beta, and IL-6 in SH-SY5Y and HMC3 cells.	Palmitic Acid	244-246	interleukin 1 alpha	Homo sapiens	351-359
34879371-8	2021	miRNA-141-3p induced NLRP3, IL-1beta, and IL-18 production, decreased CXCR4, MMP, and MMP2 production, and suppressed cell growth and invasion.	mirna-141-3p	0-12	interleukin 1 alpha	Homo sapiens	28-36
34247997-0	2021	Association of IL-6 & IL-1beta (pro-inflammatory cytokines) and related biochemical indexes in newly diagnosed diabetics subjected to glucose tolerance test.	Glucose	134-141	interleukin 1 alpha	Homo sapiens	22-30
34589729-9	2021	Maternal poly(I:C) induced changes in IL-1beta, Il-10 and TNF-alpha concentrations were small and could not be associated with age of offspring, gestational period or sampling location.	Poly I-C	9-18	interleukin 1 alpha	Homo sapiens	38-46
35398417-4	2022	Here, we evaluated the associations between PM10, NO2 and O3 exposure (on the day of the blood sample collection and on the day before, and the mean annual residential level) and levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-17A, IL-22, and tumor necrosis factor alpha.	pm10	44-48	interleukin 1 alpha	Homo sapiens	262-284
35551917-7	2022	Moreover, we identified Doxo-induced senescence to be mediated by the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome, a key player of the immune innate system capable of releasing interleukin (IL)-1beta.	Doxorubicin	24-28	interleukin 1 alpha	Homo sapiens	204-226
35533545-9	2022	The results suggested that ameliorating cisplatin-induced AKI actions of 9b was involved in downregulation of TNF-alpha, IL-1beta, IL-6, and MCP-1, inhibition of NF-kB activation, and reduction of GRPR and oxidative stress level.	Cisplatin	40-49	interleukin 1 alpha	Homo sapiens	121-129
35551917-8	2022	In fact, IL-1beta itself mimicked the stimulatory action of Doxo on both NLRP3 activation and cellular senescence, while the pharmacological blockade of IL-1 receptors markedly attenuated the pro-senescence effects of Doxo.	Doxorubicin	60-64	interleukin 1 alpha	Homo sapiens	9-17
35482438-5	2022	HYPOTHESIS: Treatment of articular cartilage with IL-1Ra in combination with a clinically relevant concentration of lidocaine (1%) will inhibit the catabolic effects of IL-1alpha in a manner similar to treatment with IL-1Ra alone.	Lidocaine	116-125	interleukin 1 alpha	Homo sapiens	169-178
35346830-8	2022	The overexpression of miR-1656 can induce increased expression of pyroptosis-related genes including NLRP3, Caspase-1, IL-18, and IL-1beta by inhibiting the release of GPX4.	mir-1656	22-30	interleukin 1 alpha	Homo sapiens	130-138
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	interleukin 1 alpha	Homo sapiens	156-164
35306042-11	2022	TFH decreased the levels of IL-1alpha, IL-1beta, IL-6, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), platelet-derived growth factor (PDGF)-BB, thymus and activation regulated chemokine (TARC) in the supernatants of the HaCaT cells treated by IFN-gamma/TNF-alpha.	tfh	0-3	interleukin 1 alpha	Homo sapiens	28-37
35306042-11	2022	TFH decreased the levels of IL-1alpha, IL-1beta, IL-6, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), platelet-derived growth factor (PDGF)-BB, thymus and activation regulated chemokine (TARC) in the supernatants of the HaCaT cells treated by IFN-gamma/TNF-alpha.	tfh	0-3	interleukin 1 alpha	Homo sapiens	39-47
35148063-9	2022	After adjusting for other covariates, higher PM2.5-bound copper was significantly associated with increased levels of interleukin (IL)1beta, IL6, IL10, and IL17 levels.	Copper	57-63	interleukin 1 alpha	Homo sapiens	118-139
35297523-9	2022	In BPDE combined with 4-PBA intervention group, the rate of PI-positive cells was reduced, the expression levels of GRP78, GSDMD-N, and cleaved-caspase 1 were decreased, and the expression levels of IL-1beta, IL-18, and NLRP3 were decreased.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	3-7	interleukin 1 alpha	Homo sapiens	199-207
35471938-7	2022	Our data provide evidence that IL-1beta blockade may serve as a preventive strategy among high-risk individuals and an alternative therapeutic approach in combination with currently available treatments for KM-LUAD.	km-luad	207-214	interleukin 1 alpha	Homo sapiens	31-39
35129804-6	2022	The supernatant levels of TNF-alpha, IL-1beta, and IL-6 in the high-dosage ginkgolide-treated groups were lower than those in the control group.	Ginkgolides	75-85	interleukin 1 alpha	Homo sapiens	37-45
35482438-11	2022	RESULTS: The combination of IL-1Ra and lidocaine, premixed at various time points and stored at room temperature or 4 C, was as effective as IL-1Ra alone at inhibiting IL-1alpha-mediated sGAG release.	Lidocaine	39-48	interleukin 1 alpha	Homo sapiens	168-177
35482438-13	2022	CONCLUSION: Our hypothesis was supported, and results indicated that the combination of IL-1Ra and lidocaine was as efficacious as IL-1Ra treatment alone in acutely mitigating biological cartilage injury due to IL-1alpha in an explant model.	Lidocaine	99-108	interleukin 1 alpha	Homo sapiens	211-220
34993951-11	2022	GBA activity and GlcChol correlated with TEWL and levels of multiple cytokines, especially IL1alpha and IL-18.	glcchol	17-24	interleukin 1 alpha	Homo sapiens	91-99
35623848-6	2022	The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production.	Ascorbic Acid	115-124	interleukin 1 alpha	Homo sapiens	207-215
35623848-6	2022	The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production.	Vitamin E	129-138	interleukin 1 alpha	Homo sapiens	207-215
34997266-14	2022	PQQ inhibits ROS generation and NF-kappaB activation, which stimulates activation of the NLRP3 inflammasome and regulates the expression of caspase-1, IL-1beta, and IL-18.	PQQ Cofactor	0-3	interleukin 1 alpha	Homo sapiens	151-159
35447530-9	2022	Crocin caused a significant reduction of levels of TNF-alpha and IL-1beta, suggesting that crocin suppressed inflammation in BC cells.	crocin	0-6	interleukin 1 alpha	Homo sapiens	65-73
35447530-9	2022	Crocin caused a significant reduction of levels of TNF-alpha and IL-1beta, suggesting that crocin suppressed inflammation in BC cells.	crocin	91-97	interleukin 1 alpha	Homo sapiens	65-73
35219165-10	2022	Furthermore, PR-957 treatment or CD4+ T cell depletion in chronic liver injury alleviated liver fibrosis and reduced inflammation, as indicated by the downregulation of inflammatory response markers (F4/80, IL-1, IL-6 and IL-18).	PR-957	13-19	interleukin 1 alpha	Homo sapiens	207-211
35347345-6	2022	For M1 macrophage polarization, sodium butyrate significantly intensified the antiinflammatory function of PSLs, inhibiting LPS-induced proinflammatory genes expression, cytokines and enzyme release (tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and inducible nitric oxide synthase), as well as CD86 (M1 marker) expression.	Butyric Acid	32-47	interleukin 1 alpha	Homo sapiens	229-251
35271969-6	2022	RESULTS: IL-1beta and NLRP3 expression were higher in both unstimulated and PA treated monocytes from obese compared to non-obese subjects.	Palmitic Acid	76-78	interleukin 1 alpha	Homo sapiens	9-17
35271969-8	2022	Sulforaphane reduced TNF-alpha and IL-1beta from monocytes in both groups, however inflammasome associated genes were only reduced in monocytes from obese subjects.	sulforaphane	0-12	interleukin 1 alpha	Homo sapiens	35-43
35622407-1	2022	To evaluate the immunomodulatory effect of minocycline, the present study was carried out on the gene expression of toll-like receptor type-4 (TLR4) and some pro-inflammatory (IL-1beta, IL-6) and anti-inflammatory cytokines (IL-10) associated with lipopolysaccharide (LPS) -induced inflammation in human peripheral blood mononuclear cells (PBMCs).	Minocycline	43-54	interleukin 1 alpha	Homo sapiens	176-184
35000557-7	2022	Anti-inflammatory and anti-apoptotic activities of catechin and EGCG were investigated by indirect immunocytochemistry using anti-TNF-alpha, anti-IL-1beta and anti-caspase-3.	Catechin	51-59	interleukin 1 alpha	Homo sapiens	146-154
35000557-12	2022	IL-1beta staining intensity weakened after catechin administration in PD model cells, after EGCG administration in SK-N-AS cells.	Catechin	43-51	interleukin 1 alpha	Homo sapiens	0-8
35000557-12	2022	IL-1beta staining intensity weakened after catechin administration in PD model cells, after EGCG administration in SK-N-AS cells.	epigallocatechin gallate	92-96	interleukin 1 alpha	Homo sapiens	0-8
35385822-8	2022	Moreover, the expression of Caspase-1, NLRP3, GSDMA, IL-18, and IL-1beta and caused membrane perforation, suggesting the development of pyroptosis by chTERT in LMH cells.	chtert	150-156	interleukin 1 alpha	Homo sapiens	64-72
35331853-7	2022	Puerarin ameliorated LPS-induced cytotoxicity and apoptosis, while repressing LPS-stimulated NLRP3 inflammasome-mediated pyroptosis in GES-1 cells, as evidenced by significantly decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta and IL-18.	puerarin	0-8	interleukin 1 alpha	Homo sapiens	233-241
35635755-6	2022	Through various metabolites (SCFAs, secondary bile acid, and serotonin), the gut microbiota plays a significant role in regulating glucose homeostasis, oxidative stress, and T2D-associated pro-inflammatory cytokines (IL-1, IL-6).	Serotonin	61-70	interleukin 1 alpha	Homo sapiens	217-221
35622407-5	2022	The IL-1beta levels were increased in the LPS group but the increases were much more intense in the other groups except Pred group.	prednylidene	120-124	interleukin 1 alpha	Homo sapiens	4-12
35616672-5	2022	Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta.	Uric Acid	19-22	interleukin 1 alpha	Homo sapiens	302-309
35616672-5	2022	Accordingly, naked MSU crystals have a highly negatively charged surface recognized by TLRs; intracellular adapter protein MyD88 are significant mediators of MSU crystals-induced IL1beta production in mice, and gouty patients demonstrate a robust positive correlation between TLR4 mRNA level and serum IL1beta.	Uric Acid	158-161	interleukin 1 alpha	Homo sapiens	302-309
35588458-5	2022	RESULTS: The main results of the correlation analysis revealed that the levels of pro-inflammatory cytokines interleukin (IL)-1beta, IL-12, and tumor necrosis factor gamma were negatively correlated with cortisol scores (area under the curve with respect to the ground).	Hydrocortisone	204-212	interleukin 1 alpha	Homo sapiens	109-131
35618242-6	2022	Transcript levels of genes involved in the IL-17A, IL-1beta, MAP kinase, and NF-kappaB signaling pathways were increasingly dysregulated by PCB126 over time.	3,4,5,3',4'-pentachlorobiphenyl	140-146	interleukin 1 alpha	Homo sapiens	51-59
35618202-3	2022	We demonstrate a new function of the anionic phospholipids POPG, DOPG, and PIP2 as inhibitors of IL-1beta release by LPS and ATP-induced inflammasome activation in human monocyte-derived and lung macrophages.	Phospholipids	45-58	interleukin 1 alpha	Homo sapiens	97-105
35618202-3	2022	We demonstrate a new function of the anionic phospholipids POPG, DOPG, and PIP2 as inhibitors of IL-1beta release by LPS and ATP-induced inflammasome activation in human monocyte-derived and lung macrophages.	1-palmitoyl-2-oleoylglycero-3-phosphoglycerol	59-63	interleukin 1 alpha	Homo sapiens	97-105
35618202-3	2022	We demonstrate a new function of the anionic phospholipids POPG, DOPG, and PIP2 as inhibitors of IL-1beta release by LPS and ATP-induced inflammasome activation in human monocyte-derived and lung macrophages.	1,2-dioleoyl-sn-glycero-3-phosphoglycerol	65-69	interleukin 1 alpha	Homo sapiens	97-105
35618202-3	2022	We demonstrate a new function of the anionic phospholipids POPG, DOPG, and PIP2 as inhibitors of IL-1beta release by LPS and ATP-induced inflammasome activation in human monocyte-derived and lung macrophages.	Phosphatidylinositol 4,5-Diphosphate	75-79	interleukin 1 alpha	Homo sapiens	97-105
35618202-3	2022	We demonstrate a new function of the anionic phospholipids POPG, DOPG, and PIP2 as inhibitors of IL-1beta release by LPS and ATP-induced inflammasome activation in human monocyte-derived and lung macrophages.	Adenosine Triphosphate	125-128	interleukin 1 alpha	Homo sapiens	97-105
35583799-7	2022	In addition, we found that inhibition of AL137857.1 suppressed the expression of a series of inflammatory cytokines, including IL-1, IL-6, TNF-alpha, Cox2 and iNOS.	al137857	41-49	interleukin 1 alpha	Homo sapiens	127-131
35578178-3	2022	METHODS: We recruited 132 subjects, detected IL1-RL1 protein level in sputum supernatant by ELISA, and analyzed the correlation between the expression level of IL1-RL1 and fraction of exhaled nitric oxide (FeNO), IgE, peripheral blood eosinophil count (EOS#), and Th2 cytokines (IL-4, IL-5, IL-10, IL-13, IL-33 and TSLP) and Th1 cytokines (IFN-gamma, IL-2, IL-8).	Nitric Oxide	192-204	interleukin 1 alpha	Homo sapiens	160-163
35584771-10	2022	GW9508 can attenuate inflammation by reducing the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 under HG.	GW9508	0-6	interleukin 1 alpha	Homo sapiens	87-95
35578178-3	2022	METHODS: We recruited 132 subjects, detected IL1-RL1 protein level in sputum supernatant by ELISA, and analyzed the correlation between the expression level of IL1-RL1 and fraction of exhaled nitric oxide (FeNO), IgE, peripheral blood eosinophil count (EOS#), and Th2 cytokines (IL-4, IL-5, IL-10, IL-13, IL-33 and TSLP) and Th1 cytokines (IFN-gamma, IL-2, IL-8).	feno	206-210	interleukin 1 alpha	Homo sapiens	160-163
35576915-11	2022	CONCLUSION: Our results show that active tVNS led to an immediate increase in the serum concentrations of certain pro-inflammatory cytokines such as IL-1beta, IL-6, and/or IL-8 in two independent cohorts of healthy study participants.	tvns	41-45	interleukin 1 alpha	Homo sapiens	149-157
35486494-7	2022	20 muM and 40 muM lupeol induced cell apoptosis, enhanced oxidative stress and restrained immune response in nasopharyngeal carcinoma cells to some extent, as evidenced by the elevation of apoptotic rate, Bax and cleaved caspase-3 expression, ROS production and malondialdehyde level, and reduction of levels of Bcl-2, MMP, superoxide dismutase, TNF-alpha, IL-6 and IL-1beta.	lupeol	18-24	interleukin 1 alpha	Homo sapiens	366-374
35551614-15	2022	The suppression of ezrin by siRNA or the blockade of ROCK activation with Y-27632 reduced the production of TNF-alpha, IL-1beta, and HMGB1 in response to LPS.	Y 27632	74-81	interleukin 1 alpha	Homo sapiens	119-127
35144170-0	2022	Molecularly imprinted polymer-based electrochemical impedimetric sensors on screen-printed carbon electrodes for the detection of trace cytokine IL-1beta.	Polymers	22-29	interleukin 1 alpha	Homo sapiens	145-153
35144170-0	2022	Molecularly imprinted polymer-based electrochemical impedimetric sensors on screen-printed carbon electrodes for the detection of trace cytokine IL-1beta.	Carbon	91-97	interleukin 1 alpha	Homo sapiens	145-153
35144170-1	2022	In this study, protein-imprinted sensors were electrochemically fabricated on screen-printed carbon electrodes (SPCEs) for the cytokine interleukin-1beta (IL-1beta) detection.	Carbon	93-99	interleukin 1 alpha	Homo sapiens	155-163
35144170-2	2022	A double layer comprising poly(o-phenylenediamine) and poly(chromotrope 2R) with a template (i.e., IL-1beta biomacromolecules) was formed through the cyclic voltammetry (CV) technique to modify the molecularly imprinted polymer (MIP) films on the SPCEs.	poly(o-phenylenediamine)	26-50	interleukin 1 alpha	Homo sapiens	99-107
35144170-4	2022	The results show that the MIP sensor has a highly sensitive response in the trace IL-1beta solution (a few pg/mL) with a limit of detection of 0.23 pg/mL and a limit of quantification of 0.78 pg/mL.	mip	26-29	interleukin 1 alpha	Homo sapiens	82-90
35144170-5	2022	Furthermore, the MIP sensor showed high selectivity for IL-1beta adsorption compared to other proteins.	mip	17-20	interleukin 1 alpha	Homo sapiens	56-64
35562512-4	2022	Vincristine-induced PN involves impaired calcium homeostasis, an increase of reactive oxygen species (ROS), and the upregulation of tumor necrosis factor-alpha (TNF-alpha), and interleukin 1 beta (IL-1beta) expression.	Vincristine	0-11	interleukin 1 alpha	Homo sapiens	197-205
35416188-5	2022	Apart from creatinine clearance and uric acid with no significant difference, quercetin significantly decreased the levels of renal index, serum/plasma creatinine (SCr), blood urea nitrogen (BUN), urine protein, urine albumin, malondialdehyde (MDA), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and increased superoxide dismutase (SOD) and catalase (CAT) activity.	Quercetin	78-87	interleukin 1 alpha	Homo sapiens	288-310
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	ursolic acid	28-40	interleukin 1 alpha	Homo sapiens	271-289
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	corosolic acid	42-56	interleukin 1 alpha	Homo sapiens	271-289
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	asiatic acid	62-74	interleukin 1 alpha	Homo sapiens	271-289
35634282-9	2022	The combination of 5-FU with ICB augmented an inflammatory tumor microenvironment with markedly increased CD8+ T cell activation and upregulation of IFNgamma, TNFalpha and IL-1beta signaling.	Fluorouracil	19-23	interleukin 1 alpha	Homo sapiens	172-180
35634282-10	2022	The effective anti-tumor immune response of 5-FU chemo-immunotherapy was dependent on CD8+ T cells but was unaffected when TNFalpha or IL-1beta cytokine signaling pathways were blocked.	Fluorouracil	44-48	interleukin 1 alpha	Homo sapiens	135-143
35631163-7	2022	EGb decreased production of TNF-alpha, IFN-gamma, and IL-10 and increased IL-15 and IL-1beta.	BDBM50323769	0-3	interleukin 1 alpha	Homo sapiens	84-92
35550411-3	2022	Earlier reports have indicated increased production of inflammatory mediators like IL-1beta and TNF-alpha by immune cells, including NK cells, lymphocytes, or monocytes, on PCP exposure.	Pentachlorophenol	173-176	interleukin 1 alpha	Homo sapiens	83-91
35628136-0	2022	Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1beta mRNA Expression.	Benzoxazoles	6-18	interleukin 1 alpha	Homo sapiens	113-121
35628136-0	2022	Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1beta mRNA Expression.	4-aminobutanamide	30-48	interleukin 1 alpha	Homo sapiens	113-121
35513427-4	2022	Stimulation of human mesangial cells with high glucose primed the inflammasome-driven interleukin 1 beta (IL-1beta) secretion, which in turn stimulated platelet-derived growth factor (PDGF-BB) release.	Glucose	47-54	interleukin 1 alpha	Homo sapiens	106-114
35534784-8	2022	Pharmacological inhibition showed that Poly(I:C)-induced IL-1alpha secretion was mediated through endoplasmic reticulum (ER) stress and RIPK1 signalling pathway.	Poly I-C	39-48	interleukin 1 alpha	Homo sapiens	57-66
35615474-13	2022	The miR-142-5p antagomir significantly reduced the IL-1beta level in T1DM aortas despite morphological changes.	mir-142-5p	4-14	interleukin 1 alpha	Homo sapiens	51-59
35525893-10	2022	CRE and TC supplementation remarkably downregulated the interleukin-1alpha, tumor necrosis factor-alpha, interleukin-1beta, acetylcholinesterase, and beta-secretase pathological gene expression.	Technetium	8-10	interleukin 1 alpha	Homo sapiens	56-74
35532840-11	2022	In turn, gastric cancer cells increase lactate production and promote gastric cell proliferation through Muc-13 and IL-1alpha stimulation.	Lactic Acid	39-46	interleukin 1 alpha	Homo sapiens	116-125
35572734-9	2022	The melanin content, TYR activity, and expression levels of TYR and TRP-1 were all raised when B16 cells were treated with 4 pg/l of IL-1.	Melanins	4-11	interleukin 1 alpha	Homo sapiens	133-137
35572734-13	2022	IL-1beta can also stimulate the expression of COX-2 and SCF in HaCaT cells, which in turn increase melanin synthesis in melanocytes.	Melanins	99-106	interleukin 1 alpha	Homo sapiens	0-8
35513427-6	2022	Both IL-1beta and PDGF-BB stimulation triggered the formation of phosphorylated sphingoid bases, as shown by lipidomics, and activated cytosolic phospholipase cPLA2, sphingosine kinase 1, cyclooxygenase 2, and autotaxin.	sphingoid bases	80-95	interleukin 1 alpha	Homo sapiens	5-13
35600853-8	2022	PN-G also reduced the levels of interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta), in a dose dependent manner, in inflamed human macrophagic THP-1 cells, thereby, reaffirming its anti-inflammatory property at cytosafe concentrations.	pn-g	0-4	interleukin 1 alpha	Homo sapiens	77-85
35506586-0	2022	Orai2 channel regulates prostaglandin E2 production in TNFalpha/IL1alpha-stimulated astrocytes.	Dinoprostone	24-40	interleukin 1 alpha	Homo sapiens	64-72
35506586-3	2022	In the present study, we found that astrocytes upregulate various inflammatory factors including prostaglandin E2 (PGE2 ) by co-stimulation with tumor necrosis factor-alpha (TNFalpha) and interleukin-1alpha (IL1alpha).	Dinoprostone	97-113	interleukin 1 alpha	Homo sapiens	188-206
35506586-3	2022	In the present study, we found that astrocytes upregulate various inflammatory factors including prostaglandin E2 (PGE2 ) by co-stimulation with tumor necrosis factor-alpha (TNFalpha) and interleukin-1alpha (IL1alpha).	Dinoprostone	97-113	interleukin 1 alpha	Homo sapiens	208-216
35506586-3	2022	In the present study, we found that astrocytes upregulate various inflammatory factors including prostaglandin E2 (PGE2 ) by co-stimulation with tumor necrosis factor-alpha (TNFalpha) and interleukin-1alpha (IL1alpha).	Dinoprostone	115-119	interleukin 1 alpha	Homo sapiens	188-206
35506586-3	2022	In the present study, we found that astrocytes upregulate various inflammatory factors including prostaglandin E2 (PGE2 ) by co-stimulation with tumor necrosis factor-alpha (TNFalpha) and interleukin-1alpha (IL1alpha).	Dinoprostone	115-119	interleukin 1 alpha	Homo sapiens	208-216
35506586-4	2022	These TNFalpha/IL1alpha-stimulated astrocytes also showed increased Ca2+ release from the endoplasmic reticulum (ER) and increased expression of Orai2, a member of the store-operated calcium channel (SOCC) family.	Calcium	183-190	interleukin 1 alpha	Homo sapiens	15-23
35506586-6	2022	The expression of the prostaglandin E synthase Ptges and the production of PGE2 were higher in Orai2-KD astrocytes than in WT astrocytes when stimulated with TNFalpha and IL1alpha.	Prostaglandins E	22-37	interleukin 1 alpha	Homo sapiens	171-179
35544792-7	2022	On Ox-LDL-stimulated HUVECs, KNL significantly inhibited the production of pro-inflammatory mediators such as NO, IL-1beta, iNOS, TNF-alpha and IL-6.	kirenol	29-32	interleukin 1 alpha	Homo sapiens	114-122
35601817-4	2022	Another essential feature of hPDLSCs is their immunomodulatory activities, which are executed through cytokine (e.g., TNF-alpha and IL-1beta)-induced production of various soluble immunomediators (e.g., indoleamine-2,3-dioxygenase-1, tumor necrosis factor-inducible gene 6 protein, prostaglandin E2) and direct cell-to-cell contact (e.g., programmed cell death ligand 1, programmed cell death ligand 2).	Dinoprostone	282-298	interleukin 1 alpha	Homo sapiens	132-140
35506586-6	2022	The expression of the prostaglandin E synthase Ptges and the production of PGE2 were higher in Orai2-KD astrocytes than in WT astrocytes when stimulated with TNFalpha and IL1alpha.	Dinoprostone	75-79	interleukin 1 alpha	Homo sapiens	171-179
35520139-8	2022	Furthermore, silibinin inhibited the inflammatory reaction by inducing M2-type macrophage polarization, promoting the secretion of anti-inflammatory factors (CD206, IL-10) and inhibiting the secretion of anti-inflammatory factors (IL-1beta, iNOS).	Silybin	13-22	interleukin 1 alpha	Homo sapiens	231-239
35535052-10	2022	To that extent, CBD and other cannabis constituents such as cannabis seeds were found to reduce inflammation and expression of inflammatory cytokines including TNF-alpha and IL-1beta when evaluated in acne-like conditions.	Cannabidiol	16-19	interleukin 1 alpha	Homo sapiens	174-182
35505045-4	2022	The effect of PGAL in an in vitro model of oxidation and synovial inflammation induced by MSU was evaluated after 24 h of stimulation through the morphological changes, the determination of oxidative stress (OS), IL-1beta, and the phagocytosis of the MSU.	L-Lysine L-glutamate	14-18	interleukin 1 alpha	Homo sapiens	213-221
35505045-9	2022	PGAL at 200 microg/ml inhibited IL-1beta by 100%, while PGAL at 100 microg/ml inhibited IL-1beta by 66%.	L-Lysine L-glutamate	0-4	interleukin 1 alpha	Homo sapiens	32-40
35505045-9	2022	PGAL at 200 microg/ml inhibited IL-1beta by 100%, while PGAL at 100 microg/ml inhibited IL-1beta by 66%.	L-Lysine L-glutamate	56-60	interleukin 1 alpha	Homo sapiens	88-96
35586056-6	2022	Naringenin promoted M2 transition and the secretion of osteogenic cytokines including IL-4, IL-10, BMP2, and TGF-beta, while suppressing LPS-induced M1 polarization and the production of proinflammatory factors such as TNF-alpha and IL-1beta.	naringenin	0-10	interleukin 1 alpha	Homo sapiens	233-241
35635065-8	2022	miR-122-3p is downregulated in RA patients and IL-1beta-stimulated MH7A cells.	mir-122-3p	0-10	interleukin 1 alpha	Homo sapiens	47-55
35092164-7	2022	While blocking the fusion of autophagosomes with lysosomes by bafilomycin A1(BafA1), the reduced NLRP3 inflammasome activity induced by RAPA was significantly restored, with increased protein levels of NLRP3 and cleaved Casp-1(p10), as well as IL-1beta secretion.	bafilomycin A1	62-76	interleukin 1 alpha	Homo sapiens	244-252
35092164-7	2022	While blocking the fusion of autophagosomes with lysosomes by bafilomycin A1(BafA1), the reduced NLRP3 inflammasome activity induced by RAPA was significantly restored, with increased protein levels of NLRP3 and cleaved Casp-1(p10), as well as IL-1beta secretion.	Sirolimus	136-140	interleukin 1 alpha	Homo sapiens	244-252
35334282-5	2022	Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-1beta and IL-18.	Vitamin D	14-23	interleukin 1 alpha	Homo sapiens	166-174
35527664-11	2022	Additionally, through ELISA and RT-qPCR, it was uncovered that Tricin reduced the LPS-induced inflammation through regulating TNF-alpha, IL-1beta and IL-6.	tricin	63-69	interleukin 1 alpha	Homo sapiens	137-145
35196925-12	2022	MiR-3189-3p inhibition ameliorated IL-1beta-induced chondrocyte apoptosis and ECM degradation, while SPRY1 silencing rescued the impacts.	mir-3189-3p	0-11	interleukin 1 alpha	Homo sapiens	35-43
35635065-11	2022	LINC00665 eliminates the inhibitory effect of miR-122-3p on IL-1beta-stimulated MH7A cells.	mir-122-3p	46-56	interleukin 1 alpha	Homo sapiens	60-68
35395341-6	2022	Chlorpyrifos, dithianon, and captan inhibited ROS production and TNF-alpha, IL-1beta pro-inflammatory cytokines.	dithianone	14-23	interleukin 1 alpha	Homo sapiens	76-84
35278669-4	2022	Firstly, our results confirmed that ATRA release and IL-1beta production were significantly increased in a CCl4-induced model of ALI.	Carbon Tetrachloride	107-111	interleukin 1 alpha	Homo sapiens	53-61
35278669-5	2022	In addition, we observed that ATRA could induce KCs to produce IL-1beta through retinoic acid receptor (RAR) in vitro.	Tretinoin	30-34	interleukin 1 alpha	Homo sapiens	63-71
35351591-7	2022	Furthermore, DON increased NNMT to reduce pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-11 and IL-6, and thus increased IGF-1 and cell viability, alleviating the cell growth inhibition induced by DON.	deoxynivalenol	13-16	interleukin 1 alpha	Homo sapiens	80-102
35351591-7	2022	Furthermore, DON increased NNMT to reduce pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-11 and IL-6, and thus increased IGF-1 and cell viability, alleviating the cell growth inhibition induced by DON.	deoxynivalenol	215-218	interleukin 1 alpha	Homo sapiens	80-102
35395341-6	2022	Chlorpyrifos, dithianon, and captan inhibited ROS production and TNF-alpha, IL-1beta pro-inflammatory cytokines.	Captan	29-35	interleukin 1 alpha	Homo sapiens	76-84
35277788-6	2022	Positive correlations were found between IL-1beta and fasting blood sugar and between creatinine levels and IL-17, HbA1c%, and sodium levels.	Sugars	68-73	interleukin 1 alpha	Homo sapiens	41-49
35118691-3	2022	Compared with 2"-FL or KLDS 8001 alone, 2"-FL+KLDS 8001 significantly reduced lipopolysaccharide (LPS)-induced malondialdehyde (MDA), lactate dehydrogenase (LDH) release, and cytokine (IL-1beta, IL-6, and TNF-alpha) production.	2'-fucosyllactose	14-19	interleukin 1 alpha	Homo sapiens	185-193
35561274-6	2022	Finally, 3,5-dicaffeoylquinic acid (3,5-DCQA), one of the components of S. herbacea, inhibited IL-1beta produced by NLRP3 inflammasome activity.	3,5-dicaffeoylquinic acid	9-34	interleukin 1 alpha	Homo sapiens	95-103
35561274-6	2022	Finally, 3,5-dicaffeoylquinic acid (3,5-DCQA), one of the components of S. herbacea, inhibited IL-1beta produced by NLRP3 inflammasome activity.	3,5-dicaffeoylquinic acid	36-44	interleukin 1 alpha	Homo sapiens	95-103
35315493-5	2022	Taurine was found to attenuate ER stress and prevent apoptosis in NP cells induced by IL-1beta treatment.	Taurine	0-7	interleukin 1 alpha	Homo sapiens	86-94
35405286-0	2022	Toll-like receptors in the mechanism of tributyltin-induced production of pro-inflammatory cytokines, IL-1beta and IL-6.	tributyltin	40-51	interleukin 1 alpha	Homo sapiens	102-110
35289351-11	2022	In-vitro studies revealed that nicotine lowers the expression of inflammatory cytokines (TNF, IL6, IL1beta) and proteins (TRAF2, P50, P65) at 1 microg/ml in TNFalpha induced SW982 cells.Nicotine from natural sources (Brassica oleracea) has been found to be an effective anti- inflammatory compound at a low dosage.	Nicotine	31-39	interleukin 1 alpha	Homo sapiens	99-106
35491814-10	2022	RESULTS: Pretreatment with PACs exhibited protective effects against IL-1beta-induced NP cell apoptosis including apoptosis rate, expressions of proapoptosis and antiapoptosis related genes and protein.	Proanthocyanidins	27-31	interleukin 1 alpha	Homo sapiens	69-77
35405286-3	2022	Previous studies have shown that exposure to TBT increases the cellular production (secretion plus intracellular levels) of the pro-inflammatory cytokines IL-1beta and IL-6 by peripheral blood mononuclear cells (PMBCs) and this increase requires MAPK activation.	tributyltin	45-48	interleukin 1 alpha	Homo sapiens	155-163
35405286-5	2022	The current study shows that selective inhibition of TLRs 4,1/2, and 8 diminishes the ability of TBT to stimulate IL-1beta and IL-6 production.	tributyltin	97-100	interleukin 1 alpha	Homo sapiens	114-122
35352794-8	2022	ER stress inducer significantly increased while ER stress inhibitor TUDCA significantly decreased the expression and secretion of TNF-alpha, IL-1beta and IL-8 in THP-1 cells treated by LPS.	ursodoxicoltaurine	68-73	interleukin 1 alpha	Homo sapiens	141-149
35405286-6	2022	However, selective inhibition of TLR3 enhanced the TBT-induced production of IL-1beta.	tributyltin	51-54	interleukin 1 alpha	Homo sapiens	77-85
35352794-10	2022	Furthermore, p38 inhibitor SB203580 inhibited the production and secretion of TNF-alpha, IL-1beta and IL-8 in THP-1 cells treated with LPS.	SB 203580	27-35	interleukin 1 alpha	Homo sapiens	89-97
35405286-8	2022	These results provide an important advance in understanding TBT stimulation of IL-1beta and IL-6, which has the potential to cause chronic inflammation and its attendant pathologies.	tributyltin	60-63	interleukin 1 alpha	Homo sapiens	79-87
35490837-1	2022	We previously showed that increases in reactive oxygen species (ROS) generation upregulate NLRP3 inflammasome and inflammation through increases in both caspase-1 activity and rises in IL-1beta expression levels in animal models of dry eye (DE).	Reactive Oxygen Species	39-62	interleukin 1 alpha	Homo sapiens	185-193
35490837-1	2022	We previously showed that increases in reactive oxygen species (ROS) generation upregulate NLRP3 inflammasome and inflammation through increases in both caspase-1 activity and rises in IL-1beta expression levels in animal models of dry eye (DE).	Reactive Oxygen Species	64-67	interleukin 1 alpha	Homo sapiens	185-193
35500429-8	2022	The levels of IL-1beta, TNF-alpha, and NF-kB p65 in knee OA patients with vitamin D insufficiency were significantly higher compared with the knee OA patients with sufficient vitamin D (P < 0.05).	Vitamin D	74-83	interleukin 1 alpha	Homo sapiens	14-22
35500429-9	2022	Based on the linear regression analysis, serum vitamin D levels were inversely correlated with IL-1beta, TNF-alpha, hs-CRP, and NF-kB p65 levels (P < 0.0001).	Vitamin D	47-56	interleukin 1 alpha	Homo sapiens	95-103
35624727-6	2022	In a dose-dependent manner, concomitant administration of kinetin with cisplatin significantly restored testicular oxidative stress parameters, corrected the distorted sperm quality parameters and histopathological changes, enhanced levels of serum testosterone and testicular StAR protein expression, as well as reduced the up-regulation of testicular TNF-alpha, IL-1beta, Il-6, and caspase-3, caused by cisplatin.	Kinetin	58-65	interleukin 1 alpha	Homo sapiens	364-372
35624727-6	2022	In a dose-dependent manner, concomitant administration of kinetin with cisplatin significantly restored testicular oxidative stress parameters, corrected the distorted sperm quality parameters and histopathological changes, enhanced levels of serum testosterone and testicular StAR protein expression, as well as reduced the up-regulation of testicular TNF-alpha, IL-1beta, Il-6, and caspase-3, caused by cisplatin.	Cisplatin	71-80	interleukin 1 alpha	Homo sapiens	364-372
35484857-4	2022	HPS-50 significantly decreased the levels of ALT, AST, MPO, and MDA, increased the activities of SOD, CAT, and GSH, and suppressed the LPS/D-GalN-triggered production of TNF-alpha, IL-1beta, and IL-6 (p < .05).	Galactosamine	139-145	interleukin 1 alpha	Homo sapiens	181-189
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	3-Hydroxybutyric Acid	31-34	interleukin 1 alpha	Homo sapiens	82-90
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	Adenosine	149-158	interleukin 1 alpha	Homo sapiens	82-90
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	Palmitates	175-184	interleukin 1 alpha	Homo sapiens	82-90
35572519-12	2022	The inhibitory effect of FGF21 on IL-1beta secretion was blunted with bafilomycin treatment, which blocked autophagy flux.	bafilomycin	70-81	interleukin 1 alpha	Homo sapiens	34-42
35571141-5	2022	Further exploration with the inflammatory model in THP-1 cells indicated that DHA reduced the protein expression of hypoxia-inducible factor (HIF)-1alpha and the phosphorylation in Janus kinase (JAK) 3 and signal transducer and activator of transcription (STAT) 3 protein, which resulted in a decrease in NOD-like receptor protein (NLRP) 3 expression and interleukin (IL)-1beta release.	dihydroarteannuin	78-81	interleukin 1 alpha	Homo sapiens	355-377
35448938-6	2022	In our results, the three SCFAs could inhibit ROS expressions, NLRP3, Caspase-1, IL-1beta, IL-6, IL-18, Beclin-1 and LC3-II, when induced by 5-FU.	Fluorouracil	141-145	interleukin 1 alpha	Homo sapiens	81-89
35254168-9	2022	Moreover, SVA 3D induces calcium influx and potassium efflux, which triggers IL-1beta secretion.	Calcium	25-32	interleukin 1 alpha	Homo sapiens	77-85
35254168-9	2022	Moreover, SVA 3D induces calcium influx and potassium efflux, which triggers IL-1beta secretion.	Potassium	44-53	interleukin 1 alpha	Homo sapiens	77-85
35471556-3	2022	MV treatment also decreased the production of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in C6 glial cells stimulated by LPS/IFN-gamma.	mv	0-2	interleukin 1 alpha	Homo sapiens	101-109
35573706-5	2022	Blocking HA synthesis and accumulation with 4-methylumbelliferone reduced expression of IL6, IL1beta, and TNF in both OA FLS and RA FLS co-cultures.	Hymecromone	44-65	interleukin 1 alpha	Homo sapiens	93-100
35625225-6	2022	Furthermore, cefiderocol reduces interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and TNF-alpha release in peripheral blood mononuclear cells (PBMCs) following LPS stimulation in a dose-dependent manner.	cefiderocol	13-24	interleukin 1 alpha	Homo sapiens	74-82
35530309-7	2022	It has been recently shown that Ca-EVs can activate the inflammasome cascade and IL-1beta production in tumor microenvironment-residing cells.	ca-evs	32-38	interleukin 1 alpha	Homo sapiens	81-89
35446412-11	2022	Levels of IL-1beta correlate with severity and duration of PTSD and PTSD can be prevented by bolus administration of hydrocortisone in acute sepsis, consistent with unrestrained inflammation being a risk factor for PTSD.	Hydrocortisone	117-131	interleukin 1 alpha	Homo sapiens	10-18
35441257-2	2022	Nicotine has been shown to stimulate the production of cytokines that are priming agents for inflammation that induces tissue destruction, such as IL-1beta, IL-6, and IL-8, by gingival keratinocytes and human gingival fibroblasts (HGF).	Nicotine	0-8	interleukin 1 alpha	Homo sapiens	147-155
35441257-8	2022	Nicotine elevated the expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17 and decreased the anti-inflammatory IL-10 in HGFs at 24 and 72 h. Boric acid at 100 ng/mL in the medium prevented the changes induced by nicotine alone.	Nicotine	0-8	interleukin 1 alpha	Homo sapiens	74-82
35452629-2	2022	We sought to find the correlation between the serum levels of SAA1 and IL-1beta in response to ATT in adult patients with pulmonary TB (PTB) or extra-pulmonary TB (EPTB).	Terbium	160-162	interleukin 1 alpha	Homo sapiens	71-79
35452629-9	2022	CONCLUSIONS: SAA1 and IL-1beta may be useful potential treatment-monitoring biomarkers, especially in the intensive phase of therapy for both PTB and EPTB.	eptb	150-154	interleukin 1 alpha	Homo sapiens	22-30
35529876-3	2022	In this study, a stable model of cisplatin-induced MC damage was established in vitro, and the results of PCR and Western blotting showed increased expressions of NLRP3, Caspase-1, IL-1beta, and GSDMD in MCs.	Cisplatin	33-42	interleukin 1 alpha	Homo sapiens	181-189
35563697-8	2022	Our results revealed that CBD and, for the first time, THC significantly inhibited NLRP3 inflammasome activation following LPS + ATP stimulation, leading to a reduction in the levels of IL-1beta in THP-1 macrophages and HBECs.	Cannabidiol	26-29	interleukin 1 alpha	Homo sapiens	186-194
35563697-8	2022	Our results revealed that CBD and, for the first time, THC significantly inhibited NLRP3 inflammasome activation following LPS + ATP stimulation, leading to a reduction in the levels of IL-1beta in THP-1 macrophages and HBECs.	Dronabinol	55-58	interleukin 1 alpha	Homo sapiens	186-194
35563697-8	2022	Our results revealed that CBD and, for the first time, THC significantly inhibited NLRP3 inflammasome activation following LPS + ATP stimulation, leading to a reduction in the levels of IL-1beta in THP-1 macrophages and HBECs.	Adenosine Triphosphate	129-132	interleukin 1 alpha	Homo sapiens	186-194
35443035-7	2022	Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8.	Adenosine Triphosphate	10-13	interleukin 1 alpha	Homo sapiens	153-161
35443035-7	2022	Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8.	Adenosine Diphosphate	18-21	interleukin 1 alpha	Homo sapiens	153-161
35460727-9	2022	Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels.	Uric Acid	10-19	interleukin 1 alpha	Homo sapiens	109-117
35462520-2	2022	In addition, a high carbohydrate diet can increase liver metabolic burden, increase mitochondrial oxidative phosphorylation, leading to oxidative stress, generate new fat during adenosine triphosphate synthesis, and thus resulting in ectopic fat accumulation, which further activate nuclear factor-kappaB signaling pathway and release inflam- matory factors such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and so on.	Carbohydrates	20-32	interleukin 1 alpha	Homo sapiens	414-422
35625668-4	2022	In Vitro, meclozine reduced the production of CXCL8/IL-8 and IL-1beta mRNA and protein by C. acnes-stimulated human keratinocytes and monocytes.	Meclizine	10-19	interleukin 1 alpha	Homo sapiens	61-69
35563682-6	2022	Rapa-ASCs further upregulated TNFalpha-stimulated gene-6 (TSG-6) and interleukin-1 beta (IL-1beta), indicating additional enhancement of immunomodulatory potential.	rapa-ascs	0-9	interleukin 1 alpha	Homo sapiens	89-97
35447164-7	2022	For instance, central infusion of IL-1beta or TNF-alpha can directly affect sodium and water consumption in animal models.	Sodium	76-82	interleukin 1 alpha	Homo sapiens	34-42
35447164-7	2022	For instance, central infusion of IL-1beta or TNF-alpha can directly affect sodium and water consumption in animal models.	Water	87-92	interleukin 1 alpha	Homo sapiens	34-42
35435494-8	2022	In addition, dietary supplemented with 0.18% Trp reduced the levels of serum DA, Adr, noradrenaline (NA), CRH, TDO, IDO, kynurenic acid, IL-1beta, and hypothalamic 5-HIAA/5-HT (P < 0.05), increased the levels of serum Trp, 5-HT, and IL-22, and upregulated the concentrations of hypothalamic Trp and 5-HT in heat-stressed broilers (P < 0.05).	Tryptophan	45-48	interleukin 1 alpha	Homo sapiens	137-145
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	interleukin 1 alpha	Homo sapiens	131-139
35498027-7	2022	Results: Tanshinone IIA reduced the serum levels of C-reactive protein (CRP), interleukin (IL)-1beta, IL-6, and P-selectin in KD patients; such inhibitory effect was more significant compared to aspirin and IVIG.	tanshinone	9-23	interleukin 1 alpha	Homo sapiens	78-100
35404445-1	2022	The present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1beta (IL-1beta)-triggered cellular senescence in chondrocytes.	Ketorolac	60-69	interleukin 1 alpha	Homo sapiens	162-170
35404445-1	2022	The present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1beta (IL-1beta)-triggered cellular senescence in chondrocytes.	Tromethamine	70-82	interleukin 1 alpha	Homo sapiens	162-170
35404445-3	2022	Furthermore, the upregulated cyclooxygenase-2 (COX-2) and elevated release of prostaglandin E2 (PGE2) in IL-1beta- challenged HC-A cells were dramatically repressed by ketorolac tromethamine.	Dinoprostone	78-94	interleukin 1 alpha	Homo sapiens	105-113
35404445-3	2022	Furthermore, the upregulated cyclooxygenase-2 (COX-2) and elevated release of prostaglandin E2 (PGE2) in IL-1beta- challenged HC-A cells were dramatically repressed by ketorolac tromethamine.	Dinoprostone	96-100	interleukin 1 alpha	Homo sapiens	105-113
35404445-3	2022	Furthermore, the upregulated cyclooxygenase-2 (COX-2) and elevated release of prostaglandin E2 (PGE2) in IL-1beta- challenged HC-A cells were dramatically repressed by ketorolac tromethamine.	Ketorolac Tromethamine	168-190	interleukin 1 alpha	Homo sapiens	105-113
35514993-0	2022	Oleamide-Mediated Polarization of M1 Macrophages and IL-1beta Production by Regulating NLRP3-Inflammasome Activation in Primary Human Monocyte-Derived Macrophages.	oleylamide	0-8	interleukin 1 alpha	Homo sapiens	53-61
35514993-7	2022	Results showed that oleamide promoted naive macrophages (M0) toward the M1 phenotype by upregulating M1-associated genes (IL-1beta, iNOS, CXCL10), along with downregulation of M2-associated genes (Arg-1, CD206, CCL22).	oleylamide	20-28	interleukin 1 alpha	Homo sapiens	122-130
35514993-10	2022	Whether oleamide functioned as a second signal that activated the NLRP3 inflammasome and mediated IL-1beta production was further investigated using LPS-primed MDMs followed by oleamide treatment that induced activation of inflammasome-related proteins including NLRP3, ASC, cleaved casp-1, and cleaved IL-1beta.	oleylamide	8-16	interleukin 1 alpha	Homo sapiens	98-106
35514993-10	2022	Whether oleamide functioned as a second signal that activated the NLRP3 inflammasome and mediated IL-1beta production was further investigated using LPS-primed MDMs followed by oleamide treatment that induced activation of inflammasome-related proteins including NLRP3, ASC, cleaved casp-1, and cleaved IL-1beta.	oleylamide	8-16	interleukin 1 alpha	Homo sapiens	303-311
35514993-10	2022	Whether oleamide functioned as a second signal that activated the NLRP3 inflammasome and mediated IL-1beta production was further investigated using LPS-primed MDMs followed by oleamide treatment that induced activation of inflammasome-related proteins including NLRP3, ASC, cleaved casp-1, and cleaved IL-1beta.	oleylamide	177-185	interleukin 1 alpha	Homo sapiens	98-106
35514993-11	2022	These findings suggested that oleamide promoted M1 macrophage polarization and increased IL-1beta production by activating the NLRP3 inflammasome in primary MDMs.	oleylamide	30-38	interleukin 1 alpha	Homo sapiens	89-97
35529473-1	2022	This study examined the potential mechanism of zoledronate on interleukin (IL)-1beta-induced temporomandibular joint osteoarthritis (TMJOA) chondrocytes, using IL-1beta-induced rabbit immortalized mandibular condylar chondrocytes cultured with zoledronate.	Zoledronic Acid	47-58	interleukin 1 alpha	Homo sapiens	62-84
35529473-7	2022	In conclusion, zoledronate enhances IL-1beta-induced ECM degradation and cell apoptosis in TMJOA chondrocytes.	Zoledronic Acid	15-26	interleukin 1 alpha	Homo sapiens	36-44
35426252-3	2022	We aimed to determine the effects of EGCG on C28/I2 human chondrocytes subjected to interleukin-1beta (IL-1beta)-induced oxidative stress.	epigallocatechin gallate	37-41	interleukin 1 alpha	Homo sapiens	103-111
35426252-4	2022	EGCG suppressed IL-1beta-induced oxidative stress, as indicated by decreased malondialdehyde (MDA) and reactive oxygen species (ROS) generation.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	16-24
35426252-4	2022	EGCG suppressed IL-1beta-induced oxidative stress, as indicated by decreased malondialdehyde (MDA) and reactive oxygen species (ROS) generation.	Malondialdehyde	77-92	interleukin 1 alpha	Homo sapiens	16-24
35426252-4	2022	EGCG suppressed IL-1beta-induced oxidative stress, as indicated by decreased malondialdehyde (MDA) and reactive oxygen species (ROS) generation.	Malondialdehyde	94-97	interleukin 1 alpha	Homo sapiens	16-24
35426252-4	2022	EGCG suppressed IL-1beta-induced oxidative stress, as indicated by decreased malondialdehyde (MDA) and reactive oxygen species (ROS) generation.	Reactive Oxygen Species	128-131	interleukin 1 alpha	Homo sapiens	16-24
35426252-5	2022	Additionally, EGCG attenuated the IL-1beta-induced reduction in cartilage matrix generated by chondrocytes by upregulationg collagen II, aggrecan, sulfated proteoglycans, and SRY-box transcription factor 9 (SOX9).	epigallocatechin gallate	14-18	interleukin 1 alpha	Homo sapiens	34-42
35426252-6	2022	EGCG reversed the IL-1beta-induced increased cyclooxygenase 2 (COX2), inducible nitric oxide synthase (iNOS), collagen X, and matrix metalloproteinases (MMPs).	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	18-26
35426252-7	2022	Furthermore, EGCG inhibited apoptosis and senescence of IL-1beta-treated chondrocytes, as indicated by the decrease in mitochondrial membrane potential and senescence-associated beta-galactosidase-positive cells, respectively.	epigallocatechin gallate	13-17	interleukin 1 alpha	Homo sapiens	56-64
35436742-0	2022	All-trans retinoic acid inhibits the osteogenesis of periodontal ligament stem cells by promoting IL-1beta production via NF-kappaB signaling.	Tretinoin	0-23	interleukin 1 alpha	Homo sapiens	98-106
35436742-12	2022	Levels of interleukin-1beta (IL-1beta) were increased at varied time points after ATRA treatment.	Tretinoin	82-86	interleukin 1 alpha	Homo sapiens	29-37
35436742-13	2022	The inhibitive influence of ATRA on the osteogenesis of PDLSCs was partially reversed after neutralizing IL-1beta.	Tretinoin	28-32	interleukin 1 alpha	Homo sapiens	105-113
35436742-14	2022	In addition, IL-1beta levels were significantly attenuated by nuclear factor-kappaB (NF-kappaB) inhibitor BAY11-7082 and NLRP3 inhibitor MCC950.	3-(4-methylphenylsulfonyl)-2-propenenitrile	106-116	interleukin 1 alpha	Homo sapiens	13-21
35436742-15	2022	Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation.	Tretinoin	45-49	interleukin 1 alpha	Homo sapiens	117-125
35436742-15	2022	Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation.	Tretinoin	243-247	interleukin 1 alpha	Homo sapiens	117-125
35352717-5	2022	Functional assays using human monocytes revealed that docosyl alpha-glucopyranoside leads to significantly higher levels of IL-1beta and IL-8 production by monocytes compared to those elicited by trehalose dibehenate (TDB).	docosyl alpha-glucopyranoside	54-83	interleukin 1 alpha	Homo sapiens	124-132
35352717-5	2022	Functional assays using human monocytes revealed that docosyl alpha-glucopyranoside leads to significantly higher levels of IL-1beta and IL-8 production by monocytes compared to those elicited by trehalose dibehenate (TDB).	TDB	218-221	interleukin 1 alpha	Homo sapiens	124-132
35625668-8	2022	Ex vivo experiments on human skin explants showed that meclozine decreased the production of GM-CSF, IL-1beta and TNF-alpha at transcriptional and translational levels.	Meclizine	55-64	interleukin 1 alpha	Homo sapiens	101-109
35400331-8	2022	RESULTS: Excess sucrose significantly enhanced inflammatory signal molecules (e.g., IL-1beta, IL-6, CCL2) secretion, concomitant with the enhancement of intracellular triglycerides in co-cultured HepG2 cells.	Sucrose	16-23	interleukin 1 alpha	Homo sapiens	84-92
35449546-4	2022	Methods/Design: The ACO/ARO/AIO-21 is an investigator-driven, prospective, open-labeled phase I drug-repurposing trial assessing the maximum tolerated dose (MTD) of capecitabine administered concurrently to standard preoperative radiotherapy (45 Gy in 25 fractions followed by 9 Gy boost in 5 fractions) in combination with fixed doses of the IL1-RA anakinra (100 mg, days -10 to 30).	Capecitabine	165-177	interleukin 1 alpha	Homo sapiens	343-346
35462929-11	2022	In the PF treatment groups, the apoptosis cells and levels of inflammatory factors (IL-1beta) decreased compared to those in the control groups (p = 0.000).	peoniflorin	7-9	interleukin 1 alpha	Homo sapiens	84-92
35433045-6	2022	Specifically, caspase-1 activation and secretion of its downstream product interleukin (IL)-1beta were unchanged following 14 days of C8 MCT oil supplementation when measured in unstimulated and LPS-stimulated whole blood cultures (all P > 0.05).	Oils	141-144	interleukin 1 alpha	Homo sapiens	75-97
35462936-7	2022	Furthermore, the secretion of inflammatory cytokines (IL-1beta, IL-18, IL-6, and TNF-alpha) activation of NLRP3 inflammasome and NF-kappaB signaling pathway were markedly suppressed by EC in vitro and in vivo.	Catechin	185-187	interleukin 1 alpha	Homo sapiens	54-62
35464445-2	2022	Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release.	Uric Acid	66-82	interleukin 1 alpha	Homo sapiens	316-324
35453391-6	2022	In human umbilical vein endothelial cells, SIRT3 silencing potentiated the induction of inflammatory factors by IL-1beta, including VCAM-1, ICAM-1, and MCP1, and the impairment of mitochondrial respiration, both of which were alleviated by NAD+ treatment.	NAD	240-244	interleukin 1 alpha	Homo sapiens	112-120
35021019-2	2022	Adenosine-5"-Triphosphate (ATP) triggers interleukin (IL)-1beta secretion via the P2X7 receptor (P2X7R) and activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome.	Adenosine	0-9	interleukin 1 alpha	Homo sapiens	41-63
35455444-7	2022	H2O2 reduced the cells" viability and increased the expression of the pro-inflammatory markers NF-kappaB, IL-6, IL-1beta, and TNF-alpha; by contrast, it decreased the expression of the anti-inflammatory IL-10.	Hydrogen Peroxide	0-4	interleukin 1 alpha	Homo sapiens	112-120
35021019-2	2022	Adenosine-5"-Triphosphate (ATP) triggers interleukin (IL)-1beta secretion via the P2X7 receptor (P2X7R) and activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome.	Adenosine Triphosphate	27-30	interleukin 1 alpha	Homo sapiens	41-63
35217429-6	2022	Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle.	ros	177-180	interleukin 1 alpha	Homo sapiens	66-74
35450316-7	2022	Results: BG brought out the increased gene and protein expression of inflammatory biomarkers such as interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha, in the LPS-treated sebocytes and ORS cells.	O(6)-benzylguanine	9-11	interleukin 1 alpha	Homo sapiens	101-123
35322736-12	2022	These results unraveled that circ_0005526 promoted IL-1beta-induced chondrocyte injury in OA via suppressing miR-142-5p binding to TCF4.	mir-142-5p	109-119	interleukin 1 alpha	Homo sapiens	51-59
34990072-6	2022	The mechanistic investigation revealed that CTRP9 overexpression restrained the activation of the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome in IL-1beta-stimulated chondrocytes via the adiponectin receptor 1 (AdipoR1)/adenosine monophosphate-activated protein kinase (AMPK) axis.	Adenosine	254-263	interleukin 1 alpha	Homo sapiens	180-188
35350102-8	2022	In addition, spermine significantly reduced NLR family pyrin domain containing 3, cleaved caspase-1, N-gasdermin D and IL-1beta expression, as well as IL-1beta levels in the supernatant.	Spermine	13-21	interleukin 1 alpha	Homo sapiens	119-127
35350102-8	2022	In addition, spermine significantly reduced NLR family pyrin domain containing 3, cleaved caspase-1, N-gasdermin D and IL-1beta expression, as well as IL-1beta levels in the supernatant.	Spermine	13-21	interleukin 1 alpha	Homo sapiens	151-159
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	itaconic acid	31-40	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	Fumarates	45-53	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	dimethyl itaconate	55-73	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	dimethyl itaconate	75-78	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	4-Octyl Itaconate	81-98	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	(1~{R},2~{R})-~{N}-(1~{H}-pyrazol-4-yl)-2-pyridin-3-yl-cyclopropane-1-carboxamide	100-103	interleukin 1 alpha	Homo sapiens	171-179
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	Dimethyl Fumarate	109-126	interleukin 1 alpha	Homo sapiens	171-179
35464168-3	2022	UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control.	Polyphenols	171-181	interleukin 1 alpha	Homo sapiens	46-55
35464168-3	2022	UVA exposure increased the gene expression of IL-1alpha, the mRNA levels of MMP-1, and hence, the levels of MMP-1 protein in HaCaT cells, whereas cells treated with lotus polyphenol (LP) normalized these values to the control.	leucylproline	183-185	interleukin 1 alpha	Homo sapiens	46-55
35464168-4	2022	In the presence of LP at concentrations of 1 and 10 mug/mL, both the secretion of IL-1alpha and protein levels of MMP-1 in human keratinocyte cells significantly reduced.	leucylproline	19-21	interleukin 1 alpha	Homo sapiens	82-91
35178861-15	2022	In both CVB3 FB and HL-1 cells, colchicine down-regulated the NLRP3 inflammasome-related components ASC, caspase-1, and IL-1beta.	Colchicine	32-42	interleukin 1 alpha	Homo sapiens	120-128
35311434-2	2022	Drugs blocking the NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome/interleukin-1beta (IL-1beta) axis are beneficial in patients with multiple recurrences.	Leucine	26-33	interleukin 1 alpha	Homo sapiens	125-133
35432339-8	2022	We identified increased gene expression of specific pro-inflammatory cytokines (Il-6, Il-1beta, Il-12) when O-GlcNAc cycling was blocked.	o-glcnac	108-116	interleukin 1 alpha	Homo sapiens	86-94
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	Dimethyl Fumarate	128-131	interleukin 1 alpha	Homo sapiens	171-179
35137954-5	2022	DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1beta release.	dimethyl itaconate	0-3	interleukin 1 alpha	Homo sapiens	323-331
35137954-5	2022	DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1beta release.	citraconic acid	39-42	interleukin 1 alpha	Homo sapiens	323-331
35137954-7	2022	The derivatives also reduced pro-IL-1alpha cleavage in response to the calcium ionophore ionomycin.	Calcium	71-78	interleukin 1 alpha	Homo sapiens	33-42
35137954-7	2022	The derivatives also reduced pro-IL-1alpha cleavage in response to the calcium ionophore ionomycin.	Ionomycin	89-98	interleukin 1 alpha	Homo sapiens	33-42
35137954-9	2022	Furthermore, we highlight itaconate and fumarate derivatives as potential therapeutic options in NLRP3- and IL-1alpha-driven diseases, including in the brain.	Fumarates	40-48	interleukin 1 alpha	Homo sapiens	108-117
35217429-9	2022	In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis.	ros	162-165	interleukin 1 alpha	Homo sapiens	62-70
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	112-143	interleukin 1 alpha	Homo sapiens	56-64
35059921-9	2022	After treatment with TAL-6, the serum levels of TNF-alpha, IL-1beta, and IL-6 were significantly decreased, and sepsis-induced pathological injuries in the kidney were remarkably attenuated.	tal-6	21-26	interleukin 1 alpha	Homo sapiens	59-67
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 alpha	Homo sapiens	56-64
35443443-14	2022	A weak negative correlation of IL-1 and TNF-alpha was seen with vitamin D in diabetics without nephropathy, whereas IL-6 had a weak negative correlation with vitamin D in diabetics with nephropathy.	Vitamin D	64-73	interleukin 1 alpha	Homo sapiens	31-35
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Hydrogen	42-44	interleukin 1 alpha	Homo sapiens	0-8
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Hydrogen	42-44	interleukin 1 alpha	Homo sapiens	50-58
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Tritium	81-83	interleukin 1 alpha	Homo sapiens	0-8
35199410-10	2022	CONCLUSION: When compared to normal women, IL-34, IL-6, TNF-alpha, and IL-1beta levels were highly statistically significant in PCOS, and these high levels were associated with other cytokines (IL-6, TNF-alpha, and IL-1beta), HOMA-IR, triglyceride, and LDL-C.	Triglycerides	235-247	interleukin 1 alpha	Homo sapiens	71-79
35152538-11	2022	Finally, ethanol induced hepatocellular steatosis, SREBP1 transcription, and modulated the expression of SREBP1c, ACAC, ACLY, FASN, IL-1beta, IL-6, TNF-alpha, GPC3, FLNB and p53.	Ethanol	9-16	interleukin 1 alpha	Homo sapiens	132-140
35286533-7	2022	Moreover, captopril significantly reduced the inflammation markers including NF-kB, IL-1 beta, COX-1, and COX-2 levels.	Captopril	10-19	interleukin 1 alpha	Homo sapiens	84-93
35158039-9	2022	In addition, codeine triggered an increase in the ovarian concentration of inflammatory cytokines, TNF-alpha and IL-1beta, and myeloperoxidase activity.	Codeine	13-20	interleukin 1 alpha	Homo sapiens	113-121
35131633-10	2022	RESULTS: VX-765 reduced IIRI-induced oxidative stress and inflammatory response both in vivo and in vitro, while it decreased the levels of TNF-alpha, IL-6, IL-1beta as well as the modified Park/Chiu scores.	belnacasan	9-15	interleukin 1 alpha	Homo sapiens	157-165
35431807-5	2022	In human whole blood cultures pCF3-diEPP inhibited the LPS-induced secretion of IL-6, TNF-alpha and IL-1beta.	pcf3-diepp	30-40	interleukin 1 alpha	Homo sapiens	100-108
35583056-9	2022	Paeonol treatment concentration-dependently suppressed LPS induced mRNA expression of inflammatory cytokines including TNF-alpha, IL-1beta, IL-6, and IL-12 by BV2 microglia.	paeonol	0-7	interleukin 1 alpha	Homo sapiens	130-138
35431807-6	2022	The ATP-mediated release of IL-1beta by LPS-primed human peripheral blood mononuclear leukocytes, monocytic THP-1 cells and THP-1-derived M1-like macrophages was reduced by both phosphocholine and femtomolar concentrations of pCF3-diEPP.	Adenosine Triphosphate	4-7	interleukin 1 alpha	Homo sapiens	28-36
35431807-6	2022	The ATP-mediated release of IL-1beta by LPS-primed human peripheral blood mononuclear leukocytes, monocytic THP-1 cells and THP-1-derived M1-like macrophages was reduced by both phosphocholine and femtomolar concentrations of pCF3-diEPP.	Phosphorylcholine	178-192	interleukin 1 alpha	Homo sapiens	28-36
35431807-6	2022	The ATP-mediated release of IL-1beta by LPS-primed human peripheral blood mononuclear leukocytes, monocytic THP-1 cells and THP-1-derived M1-like macrophages was reduced by both phosphocholine and femtomolar concentrations of pCF3-diEPP.	pcf3-diepp	226-236	interleukin 1 alpha	Homo sapiens	28-36
35431807-12	2022	However, both agonists signal via nAChR subunits alpha7, alpha9 and/or alpha10 to efficiently down-modulate the ATP-induced release of IL-1beta.	Adenosine Triphosphate	112-115	interleukin 1 alpha	Homo sapiens	135-143
35456796-8	2022	The anti-inflammatory properties of stevioside were confirmed in vitro by decreasing TNF-alpha, IL-1beta, IL-6 synthesis and inhibiting of NF-kappaB transcription factor, and in vivo by inhibiting NF-kappaB and MAPK in laboratory animals.	stevioside	36-46	interleukin 1 alpha	Homo sapiens	96-104
35431964-5	2022	Meanwhile, miR-130a-3p could ameliorate pulmonary lesions by downregulating the secretion of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha, and TGF-beta1) and the deposition of ECM (alpha-SMA, FN, HYP, and collagen) in the inflammatory and fibrotic phase, respectively.	mir-130a-3p	11-22	interleukin 1 alpha	Homo sapiens	117-125
35362396-3	2022	METHODS: The in-vitro enzyme inhibitory activity of saccharumoside-B on PLA2, COX-1, COX-2, and 5-LOX enzymes were evaluated by the cell-free method, its effect on TNF-alpha, IL-1beta, and IL-6 secretion levels in LPS stimulated THP-1 human monocytes was determined by ELISA based methods.	Saccharumoside B	52-68	interleukin 1 alpha	Homo sapiens	175-183
35351143-5	2022	It has been reported that the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) 3 inflammasome, which contributes to the activation of interleukin-1 beta (IL-1beta), might be related to the progression of endometriosis.	Leucine	73-80	interleukin 1 alpha	Homo sapiens	204-212
35378948-0	2022	Clinical Effect of Bushen Huoxue Method Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis and Its Effect on IL-1, IL-6, VEGF, and PGE-2.	huoxue	26-32	interleukin 1 alpha	Homo sapiens	133-137
35408584-8	2022	Measuring IL-6, TNFalpha, and IL-1beta pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells.	calceolarioside A	108-125	interleukin 1 alpha	Homo sapiens	30-38
35322136-0	2022	NaCl exposure results in increased expression and processing of IL-1beta in Meniere"s disease patients.	Sodium Chloride	0-4	interleukin 1 alpha	Homo sapiens	64-72
35368876-10	2022	Our results indicated that PEITC decreased the cell viability and inhibited the protein levels and expressions of IL-1beta, IL-6, and TNF-alpha genes at the transcriptional level in GBM 8401 cells.	phenethyl isothiocyanate	27-32	interleukin 1 alpha	Homo sapiens	114-122
35408478-8	2022	Moreover, theasaponin E1 reduced inflammation by suppressing the Nf-kB pathway and dose-dependently reducing the levels of inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha etc.	theasaponin E1	10-24	interleukin 1 alpha	Homo sapiens	154-162
35401236-4	2022	In vivo, our results showed that AKEX0011 ameliorated silica-induced imaging lung damages, respiratory dysfunction, reduced the secretion of inflammatory and fibrotic factors (TNF-alpha, IL-1beta, IL-6, TGF-beta, IL-4, and IL-10), and the deposition of fibrosis-related proteins (collagen I, fibronectin, and alpha-SMA), regardless of early or advanced therapy.	Silicon Dioxide	54-60	interleukin 1 alpha	Homo sapiens	187-195
35466217-6	2022	Further ex vivo and in vitro experiments revealed that ZnONPs enhanced the migration of PMNs, promoted their bacterial phagocytosis efficiency, proinflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) expression, and reactive oxygen species (ROS) production.	znonps	55-61	interleukin 1 alpha	Homo sapiens	181-189
35322136-4	2022	In the present study, we characterize the production, processing and release of the pro-inflammatory cytokines IL-1beta and IL-6 from PBMC of MD (n = 14) patients in response to sodium chloride (NaCl), and determined the effect of the diuretic triamterene-hydrocholothiazide (T-HCTZ), or anakinra in these patients.	Sodium Chloride	178-193	interleukin 1 alpha	Homo sapiens	111-119
35322136-5	2022	We observed that PBMC cultured with NaCl from MD patients show processing of IL-1beta to the 28 kDa product, and that this product is abrogated with T-HCTZ.	Sodium Chloride	36-40	interleukin 1 alpha	Homo sapiens	77-85
35387091-4	2022	The administration of TA also inhibited (P < 0.05) the expression of intestinal pro-inflammatory cytokines including interleukin (IL)-1beta, IL-8, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) but increased (P < 0.05) jejunal IL-10 and secretory immunoglobulin A (sIgA) concentration.	anethole	22-24	interleukin 1 alpha	Homo sapiens	117-139
35260353-4	2022	In this longitudinal observational trial, we show that ivacaftor therapy leads to a significant reduction in sputum IL-1beta concentration but not in other IL-1- or Th17-associated cytokines.	ivacaftor	55-64	interleukin 1 alpha	Homo sapiens	116-124
35315432-3	2022	Mechanistically, Panx1 on endothelial cells acts as a conduit for ATP release that stimulates macrophage activation via P2X7 receptors and mitochondrial DNA release to increase IL-1beta and HMGB1 secretion.	Adenosine Triphosphate	66-69	interleukin 1 alpha	Homo sapiens	177-185
35370689-4	2022	Recent studies have shown that the modulation of MSU-induced inflammatory responses is dependent on the inflammatory cytokine IL-1beta, which has a central role in a chain of processes involving multiple cytokines and mediators.	msu	49-52	interleukin 1 alpha	Homo sapiens	126-134
35183871-7	2022	Further studies showed that J114 displayed remarkable inhibitory activity against NLRP3- and AIM2-but not NLRC4-dependent activation of caspase-1 and the release of IL-1beta in human THP-1 macrophages.	Cancell	28-32	interleukin 1 alpha	Homo sapiens	165-173
35255173-7	2022	Then, the selected compound (diene 1) was evaluated as to its ability to inhibit the secretion of pro-inflammatory cytokines (IL-1beta, TNF-alpha, INF-gamma, MCP-1, and IL-6) and increase the production of anti-inflammatory cytokines (IL-13, IL-4, and IL-10).	diene	29-34	interleukin 1 alpha	Homo sapiens	126-134
35370605-0	2022	Mediation Effects of IL-1beta and IL-18 on the Association Between Vitamin D Levels and Mild Cognitive Impairment Among Chinese Older Adults: A Case-Control Study in Taiyuan, China.	Vitamin D	67-76	interleukin 1 alpha	Homo sapiens	21-29
35370629-5	2022	In our previous research, we used computer simulations to design the multifunctional peptide KCF18 that can bind to TNF-alpha, IL-1beta, and IL-6 based on the binding regions of receptors and proinflammatory cytokines.	kcf18	93-98	interleukin 1 alpha	Homo sapiens	127-135
35370629-7	2022	Cell experiments demonstrated that KCF18 significantly reduced the binding of proinflammatory cytokines to their cognate receptors and inhibited the mRNA and protein expressions of TNF-alpha, IL-1beta, and IL-6.	kcf18	35-40	interleukin 1 alpha	Homo sapiens	192-200
35191475-9	2022	Cordycepin treatment resulted in around 50% inflammatory cytokine production (e.g., IL-6 and IL-1beta) and about 60% immune cell infiltration (e.g., Th17 cells) when compared to vehicle control group.	cordycepin	0-10	interleukin 1 alpha	Homo sapiens	93-101
35246037-11	2022	An increase in IL-1beta mRNA levels due to postinjury application of midazolam was reversible by flumazenil administration.	Midazolam	69-78	interleukin 1 alpha	Homo sapiens	15-23
35246037-11	2022	An increase in IL-1beta mRNA levels due to postinjury application of midazolam was reversible by flumazenil administration.	Flumazenil	97-107	interleukin 1 alpha	Homo sapiens	15-23
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	interleukin 1 alpha	Homo sapiens	52-60
35236262-5	2022	The co-activation of toll-like receptors 4 (TLR4) by lipopolysaccharide, a constituent of the cell membrane of gram negative bacteria, and the P2X7R by ATP leads to the generation and release of the pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Adenosine Triphosphate	152-155	interleukin 1 alpha	Homo sapiens	245-253
35262071-4	2022	Mechanistically, BCG adjuvant effects on COVISHIELDTM induced adaptive responses was associated with more robust innate responses to pathogen-associated-molecular-patterns through TNF-alpha and IL-1beta secretion.	covishieldtm	41-53	interleukin 1 alpha	Homo sapiens	194-202
35041813-8	2022	Mechanistically, we found that GCV could reverse the levels of pro-inflammatory factors (such as IL-1beta) and chemokine-related factors (such as Cxcr3), possibly via targeting the STING pathway.	Ganciclovir	31-34	interleukin 1 alpha	Homo sapiens	97-105
35066451-10	2022	However, levels of the cytokines IL-1ra and IL-1 beta decreased significantly (p < 0.04 or less) in patients with high vs. low GADA when adjusted for BMI, age, gender (male/female), treatment (insulin/sitagliptin) and study site (Norwegian/Swedish).	Sitagliptin Phosphate	201-212	interleukin 1 alpha	Homo sapiens	44-53
35092909-0	2022	Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1beta-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-kappaB and MAPKs signaling pathways and inducing apoptosis.	Alkaloids	49-58	interleukin 1 alpha	Homo sapiens	70-78
35092909-9	2022	RESULTS: FLA had a significant inhibitory effect on the proliferation of HFLS-RA induced by IL-1beta, which was accompanied by decreased expression levels of TNF-alpha, IL-6, MMP-1, MMP-3, COX-2 and PGE2.	fla	9-12	interleukin 1 alpha	Homo sapiens	92-100
35092909-9	2022	RESULTS: FLA had a significant inhibitory effect on the proliferation of HFLS-RA induced by IL-1beta, which was accompanied by decreased expression levels of TNF-alpha, IL-6, MMP-1, MMP-3, COX-2 and PGE2.	Dinoprostone	199-203	interleukin 1 alpha	Homo sapiens	92-100
35092909-10	2022	Remarkably, FLA inhibited the activation of NF-kappaB and MAPKs signaling pathways in IL-1beta-induced HFLS-RA, as well as inducing HFLS-RA apoptosis through the mitochondrial apoptosis pathway.	fla	12-15	interleukin 1 alpha	Homo sapiens	86-94
35126722-7	2022	Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1beta and tumor necrosis factor-alpha.	Melatonin	63-72	interleukin 1 alpha	Homo sapiens	154-162
35299960-11	2022	These results suggest that miR-218-5p inhibits the TGFbeta/SMAD2 pathway to induce IL1beta and enEVT differentiation.	mir-218-5p	27-37	interleukin 1 alpha	Homo sapiens	83-90
35023144-11	2022	In beagle models that received TmLRP, HSP70, NLRP3, Caspase-1, IL-1beta, and IL-18 were highly expressed in the wound tissue or urine, and could also be reduced by NAC pretreatment.	Acetylcysteine	164-167	interleukin 1 alpha	Homo sapiens	63-71
35124344-0	2022	MiR-624-5p enhances NLRP3 augmented gemcitabine resistance via EMT/IL-1beta/Wnt/beta-catenin signaling pathway in ovarian cancer.	gemcitabine	36-47	interleukin 1 alpha	Homo sapiens	67-75
35124344-4	2022	In case of gemcitabine-resistant cells, the up-regulation of NLRP3 can increase the drug-resistance through the activation of IL-1beta, EMT and Wnt/beta-catenin signaling pathways.	gemcitabine	11-22	interleukin 1 alpha	Homo sapiens	126-134
35059736-12	2022	Furthermore, nicotine exposure increased the expression levels of caspase-1, IL-1beta, IL-18, NLRP3, apoptosis-associated speck-like protein and gasdermin D in 16HBE cells.	Nicotine	13-21	interleukin 1 alpha	Homo sapiens	77-85
35164664-6	2022	Nintedanib reduced the production of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in TNF-alpha-induced CHON-001 chondrocytes.	nintedanib	0-10	interleukin 1 alpha	Homo sapiens	108-116
35113170-3	2022	Since colchicine is an anti-inflammatory drug with the ability to block NLRP3 inflammasome oligomerization, this may prevent the release of active IL-1beta and block the detrimental effects of downstream cytokines, i.e. IL-6.	Colchicine	6-16	interleukin 1 alpha	Homo sapiens	147-155
35090964-3	2022	Moreover, apoptosis and inflammatory response were promoted after the co-exposure of ZEA and DON, indicated by the increased expression of BAX, Caspase-3, IL-1beta and IL-6 genes.	Zearalenone	85-88	interleukin 1 alpha	Homo sapiens	155-163
35269821-5	2022	We found that 2-(8-methoxy-2-methyl-4-oxoquinolin-1(4H)-yl)-N-(3-methoxyphenyl) acetamide attenuated IL-1beta-induced MMP13 mRNA expression in a dose-dependent manner, without causing serious cytotoxicity.	2-(8-methoxy-2-methyl-4-oxoquinolin-1(4h)-yl)-n-(3-methoxyphenyl) acetamide	14-89	interleukin 1 alpha	Homo sapiens	101-109
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Alcohols	47-54	interleukin 1 alpha	Homo sapiens	199-207
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Atorvastatin	58-62	interleukin 1 alpha	Homo sapiens	199-207
35545412-22	2022	CONCLUSIONS: Intraoperative dexmedetomidine infusion can reduce the incidence of POCD and POD in elderly patients undergoing hepatic lobectomy, and the protective mechanism appears to involve the down-regulation of TNF-alpha and IL-1beta and upregulation of IL-10 expression, which lead to rebalance between proinflammation and anti-inflammation.	Dexmedetomidine	28-43	interleukin 1 alpha	Homo sapiens	229-237
35545412-19	2022	Compared with the Dex1 group, the level of IL-1beta at T2 and IL-10 from T1 to T3 elevated in the Dex2 group (all P<0.05).	dex2	98-102	interleukin 1 alpha	Homo sapiens	43-51
35209841-9	2022	Genistein pretreatment suppressed the expression of proinflammatory cytokines (CXCL1, IL-1, MIF, and PLANH1) and the proteins released by UVB-treated keratinocytes.	Genistein	0-9	interleukin 1 alpha	Homo sapiens	86-90
35133137-11	2022	Ga implantation of the surface also resulted in reduced foreign body giant cell formation and expression of proinflammatory cytokine IL-1beta.	Gallium	0-2	interleukin 1 alpha	Homo sapiens	133-141
35284413-6	2022	IL-1beta induced up-regulation of ELF3, down-regulation of degeneration molecules (Collagen II, Aggrecan, and Sox9), up-regulation of matrix metalloproteinase (MMP-1, MMP-3, and MMP-13), and up-regulation of inflammatory molecules (IL-6, MCP-1, TNF-alpha, COX-2, and iNOS) could be inhibited by SMSC-212-5p-Exos or SMSC-Exos administration.	smsc-212-	295-304	interleukin 1 alpha	Homo sapiens	0-8
35242878-10	2022	Proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs.	Bile Acids and Salts	141-143	interleukin 1 alpha	Homo sapiens	27-35
35273600-5	2022	In this study, we firstly found that arterial serum of Coronary Heart Disease (CHD) patients contained significantly higher succinate and interleukin (IL)-1beta than Health control (HC) subjects, and succinate was positively correlated with IL-1beta.	Succinic Acid	200-209	interleukin 1 alpha	Homo sapiens	241-249
35273600-7	2022	Under the coculture, activated macrophages released succinate, which would be transferred to HUVECs via Sucnr1 and then activate Hif-1alpha to produce a greater amount of IL-1beta.	Succinic Acid	52-61	interleukin 1 alpha	Homo sapiens	171-179
35382471-5	2022	BPBA inhibited self- and Cu2+- or Zn2+-induced Abeta aggregation, disaggregated the already formed Abeta aggregates, and reduced the neurotoxicity of Abeta aggregates; it also inhibited the activation of the NLRP3 inflammasome and reduced the release of IL-1beta in vitro and vivo.	2-Bromopyridine-5-boronic acid	0-4	interleukin 1 alpha	Homo sapiens	254-262
35187677-11	2022	alpha-Mangostin treatment also inhibited the LPS-induced increase in expression levels of NLRP3, ASC and pro-caspase-1, as well as the production of IL-1beta and IL-18 in NPCs.	mangostin	0-15	interleukin 1 alpha	Homo sapiens	149-157
35172843-6	2022	METHODS: Biochemical techniques including quantification of IL-1beta secretion and confocal microscopy were employed to gain insight into dopamine signaling-mediated inhibition of the NLRP3 inflammasome mechanism in primary human microglia and the SYN120 transgenic mouse model.	Dopamine	138-146	interleukin 1 alpha	Homo sapiens	60-68
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	interleukin 1 alpha	Homo sapiens	26-34
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	interleukin 1 alpha	Homo sapiens	74-82
35204307-8	2022	The expression of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, was also suppressed by 3,5,7-trimethoxyflavone (6).	3,5,7-Trimethoxyflavone	119-142	interleukin 1 alpha	Homo sapiens	56-78
35203356-4	2022	Using IL-1beta as an inflammation inducer, we found that the induction of cyclooxygenase-2 and secretion of prostaglandins, as well as expression and release of pro-inflammatory cytokines, were significantly higher in the AhR-deficient A549 cells.	Prostaglandins	108-122	interleukin 1 alpha	Homo sapiens	6-14
35172843-9	2022	RESULTS: We show in primary human microglia that dopamine, L-DOPA, and high extracellular K+, but not norepinephrine and epinephrine, block canonical, non-canonical, and alpha-syn-mediated NLRP3 inflammasome-driven IL-1beta secretion.	Dopamine	49-57	interleukin 1 alpha	Homo sapiens	215-223
35172843-9	2022	RESULTS: We show in primary human microglia that dopamine, L-DOPA, and high extracellular K+, but not norepinephrine and epinephrine, block canonical, non-canonical, and alpha-syn-mediated NLRP3 inflammasome-driven IL-1beta secretion.	Levodopa	59-65	interleukin 1 alpha	Homo sapiens	215-223
35252733-0	2022	Correction to "Feprazone Mitigates IL-1beta-Induced Cellular Senescence in Chondrocytes".	Feprazone	15-24	interleukin 1 alpha	Homo sapiens	35-43
35273734-9	2022	The PPV+IVC group also showed lower serum levels of TNF-alpha, IL-6, and IL-1beta than the PPV group.	DOP protocol	4-7	interleukin 1 alpha	Homo sapiens	73-81
34982964-13	2022	Especially, javamide-I ester inhibited TNF-alpha, MCP-1, IL-1beta and IL-8 with IC50 values of 1.79, 0.88, 0.91 and 2.57 muM in PBMCs.	javamide-i ester	12-28	interleukin 1 alpha	Homo sapiens	57-65
35120600-3	2022	Employing a murine rectal cancer model or patient-derived tumor organoids and primary stroma cells, we show that, upon irradiation, interleukin-1alpha (IL-1alpha) not only polarizes cancer-associated fibroblasts toward the inflammatory phenotype but also triggers oxidative DNA damage, thereby predisposing iCAFs to p53-mediated therapy-induced senescence, which in turn results in chemoradiotherapy resistance and disease progression.	icafs	307-312	interleukin 1 alpha	Homo sapiens	132-150
35168647-5	2022	Compared to controls, PRP caused a significant increase in the production of IL-6 and IL-8 and there was a significant increase in IL-10 production with the use of 100 muM triamcinolone at 48 h. The production of IL1-beta and TNF-alpha was very low and did not change when the cultures were treated with triamcinolone or PRP.	Triamcinolone	172-185	interleukin 1 alpha	Homo sapiens	213-221
35168647-5	2022	Compared to controls, PRP caused a significant increase in the production of IL-6 and IL-8 and there was a significant increase in IL-10 production with the use of 100 muM triamcinolone at 48 h. The production of IL1-beta and TNF-alpha was very low and did not change when the cultures were treated with triamcinolone or PRP.	Triamcinolone	304-317	interleukin 1 alpha	Homo sapiens	213-221
35120600-3	2022	Employing a murine rectal cancer model or patient-derived tumor organoids and primary stroma cells, we show that, upon irradiation, interleukin-1alpha (IL-1alpha) not only polarizes cancer-associated fibroblasts toward the inflammatory phenotype but also triggers oxidative DNA damage, thereby predisposing iCAFs to p53-mediated therapy-induced senescence, which in turn results in chemoradiotherapy resistance and disease progression.	icafs	307-312	interleukin 1 alpha	Homo sapiens	152-161
35216089-7	2022	In CD biopsies inflammation markers IL-1beta and IL-6 were increased in the enterocytes, and also in Pot-CD before the onset of the intestinal lesion and in GFD-CD.	pot-cd	101-107	interleukin 1 alpha	Homo sapiens	36-44
35237157-9	2022	In the experiment with macrophages, XBS markedly suppressed the (Lipopolysaccharides) LPS-induced expression of NF-kappaB p65 and the production of pro-inflammatory cytokines IL-6 and IL-1beta, supporting XBS to achieve an anti-inflammatory effect through regulating NF-kappaB p65.	CHEMBL4082603	36-39	interleukin 1 alpha	Homo sapiens	184-192
35214141-12	2022	Concordantly, PTZ-loaded SLNs showed drastic reduction in the oxidative stress (e.g., malonaldehyde (MDA)) and proinflammatory cytokines (e.g., Interleukin (IL)-1beta, -6, and TNF-alpha).	Pentazocine	14-17	interleukin 1 alpha	Homo sapiens	144-166
35216089-8	2022	The inflammatory markers pNF-kappaB, pERK, IL-1beta, and IL-6 were increased and persistent in CD organoids; these organoids were more sensitive to P31-43 and Lox stimuli compared with CTR organoids.	cd organoids	95-107	interleukin 1 alpha	Homo sapiens	43-51
35216054-6	2022	Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-alpha, IL-1beta and IL-6, was observed.	sulforaphane	45-57	interleukin 1 alpha	Homo sapiens	195-203
35140310-6	2022	Conversely, the gene expression of IL-6 and IL-1beta cytokines indicated a significant decrease after application of HA-LIG, thus exhibiting a greater antiflammatory power than HA-CYN.	ha-lig	117-123	interleukin 1 alpha	Homo sapiens	44-52
35124707-17	2022	At 6 months after injection, TNF-alpha and IL-1beta levels in synovial fluid were lower in the P-PRP group (P < 0.001).	p-prp	95-100	interleukin 1 alpha	Homo sapiens	43-51
35163833-6	2022	When macrophages were stressed by lipopolysaccharides (LPS) exposure and treated by Zopolrestat, an AKR1B10 inhibitor, the LPS-induced production of IL-6, IL-1beta, and TNFalpha is significantly reduced, reinforcing the hypothesis that the pro-inflammatory expression of cytokines is AKR1B10-dependant.	zopolrestat	84-95	interleukin 1 alpha	Homo sapiens	155-163
35130850-9	2022	After treatment, the CG exhibited decreased levels of IL-1(ng/mL), IL-6 (ng/mL), and TNF-alpha (ng/mL) compared with the MG. Spearman correlation analysis revealed that IL-1, IL-6, and TNF-alpha were negatively correlated with clinical efficacy.	cg	21-23	interleukin 1 alpha	Homo sapiens	54-64
35130850-9	2022	After treatment, the CG exhibited decreased levels of IL-1(ng/mL), IL-6 (ng/mL), and TNF-alpha (ng/mL) compared with the MG. Spearman correlation analysis revealed that IL-1, IL-6, and TNF-alpha were negatively correlated with clinical efficacy.	cg	21-23	interleukin 1 alpha	Homo sapiens	169-173
35178160-7	2022	This study firstly verified the PAOX upregulation in human degenerated disc samples and applied an IL-1beta-induced nucleus pulposus (NP) cell degeneration model to demonstrate that spermidine supplementation balanced polyamine metabolism and delayed NP cell senescence.	Spermidine	182-192	interleukin 1 alpha	Homo sapiens	99-107
35185568-10	2022	As a result, KFXYS significantly reversed the uterine inflammation indexes, including IL-1 and IL-6.	kfxys	13-18	interleukin 1 alpha	Homo sapiens	86-90
35123452-11	2022	A core network containing the pro-inflammatory TNFalpha, IL-6, IL-1beta, MAPKs, and RIG-I receptor signaling pathway was further confirmed as the crucial targets for anti-influenza efficacy of TFA.	Trifluoroacetic Acid	193-196	interleukin 1 alpha	Homo sapiens	63-71
35110698-4	2022	HT-15 can selectively act on the NF-kappaB/AP1-mediated transrepression function of glucocorticoid receptor (GR) and repress the expression of pro-inflammation cytokines (i.e., IL-1beta, IL-6, COX-2, and CCL-2) as effectively as dexamethasone (Dex).	Dexamethasone	244-247	interleukin 1 alpha	Homo sapiens	177-185
35132413-8	2022	Combination NP-adjuvants targeting both TLR and RIG-I (MPLA+PUUC, CpG+PUUC, or R848+PUUC) differentially increased proinflammatory cytokine secretion (IL-1beta, IL-12p70, IL-27, IFN-beta) by APCs cultured in vitro, and induced differential T cell proliferation.	np-adjuvants	12-24	interleukin 1 alpha	Homo sapiens	151-159
35110698-4	2022	HT-15 can selectively act on the NF-kappaB/AP1-mediated transrepression function of glucocorticoid receptor (GR) and repress the expression of pro-inflammation cytokines (i.e., IL-1beta, IL-6, COX-2, and CCL-2) as effectively as dexamethasone (Dex).	Dexamethasone	229-242	interleukin 1 alpha	Homo sapiens	177-185
34847835-9	2022	We found that overexpression of USP3 hindered IL-1beta-mediated cell cycle arrest, ROS generation, and chondrocyte senescence.	Reactive Oxygen Species	83-86	interleukin 1 alpha	Homo sapiens	46-54
35123844-11	2022	Western blot analysis showed that oxidized LDL as well as TNF-alpha and IL-1beta activated the signaling of MAPKs and NF-kappab in LF cells, and that simvastatin treatment reduced the phosphorylation of all signaling.	Simvastatin	150-161	interleukin 1 alpha	Homo sapiens	72-80
35103493-11	2022	miR-140-3p was verified to target EZH2, and overexpression of miR-140-3p protected chondrocytes against IL-1beta-induced dysfunction via targeting EZH2.	mir-140-3p	62-72	interleukin 1 alpha	Homo sapiens	104-112
35094658-6	2022	Results showed that TB-II suppressed the production of reactive oxygen species, the protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1beta-stimulated SW1353 cells and chondrocytes.	timosaponin B-II	20-25	interleukin 1 alpha	Homo sapiens	158-166
35094658-6	2022	Results showed that TB-II suppressed the production of reactive oxygen species, the protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1beta-stimulated SW1353 cells and chondrocytes.	Oxides	119-124	interleukin 1 alpha	Homo sapiens	158-166
35094658-7	2022	IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition.	Nitric Oxide	42-54	interleukin 1 alpha	Homo sapiens	0-8
35094658-7	2022	IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition.	(5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oate	59-74	interleukin 1 alpha	Homo sapiens	0-8
35094658-7	2022	IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition.	timosaponin B-II	125-130	interleukin 1 alpha	Homo sapiens	0-8
35094658-7	2022	IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition.	timosaponin B-II	184-189	interleukin 1 alpha	Homo sapiens	0-8
35094658-9	2022	Mechanically, TB-II suppressed MAPKs and NF-kappaB pathways under IL-1beta stimulation evidenced by the down-regulated protein expression of p-ERK, p-p38, p-JNK, p-p65 and the reduced translocation of p65 subunit to the nucleus.	timosaponin B-II	14-19	interleukin 1 alpha	Homo sapiens	66-74
35094658-10	2022	The present study demonstrated that TB-II might become a novel therapeutic agent for OA treatment through repressing IL-1beta-stimulated inflammation, oxidative stress and ECM degradation via suppressing the MAPKs and NF-kappaB pathways.	timosaponin B-II	36-41	interleukin 1 alpha	Homo sapiens	117-125
35484121-8	2022	Moreover, both depleting miR-766-3p and promoting ADAMTS5 could partially counteract circ_0000205 knockdown roles in IL-1beta-cultured primary chondrocytes.	mir-766	25-32	interleukin 1 alpha	Homo sapiens	117-125
35040210-6	2022	Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008).	Curcumin	65-73	interleukin 1 alpha	Homo sapiens	137-145
35040210-7	2022	In addition, there was a significant difference between the nano-curcumin and control groups in the serum levels of IL-1beta (p = 0.042).	Curcumin	65-73	interleukin 1 alpha	Homo sapiens	116-124
35098408-12	2022	Moreover, miR-520-3p inhibitor downregulated the levels of inflammatory factors of TNF-alpha, IL-6, and IL-1beta, as well as suppressed NO release.	mir-520-3p	10-20	interleukin 1 alpha	Homo sapiens	104-112
35173714-6	2022	However, ATRA attenuated TGEV-induced inflammatory response by inhibiting the release of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8 and TNF-alpha.	Tretinoin	9-13	interleukin 1 alpha	Homo sapiens	127-135
35204178-5	2022	Improved antioxidant capacity of O-EGCG was observed, and there was a significant decrease in the inflammatory markers (IL-1beta, IL-6, and TNF-alpha) when O-EGCG was applied as compared to EGCG.	o-egcg	156-162	interleukin 1 alpha	Homo sapiens	120-128
35204178-5	2022	Improved antioxidant capacity of O-EGCG was observed, and there was a significant decrease in the inflammatory markers (IL-1beta, IL-6, and TNF-alpha) when O-EGCG was applied as compared to EGCG.	epigallocatechin gallate	190-194	interleukin 1 alpha	Homo sapiens	120-128
35204178-6	2022	The O-EGCG was shown to be strongly associated with the highest docking score and active site residues of IL-1, IL-6, and TNF- alpha, as well as the Mpro of SARS-CoV-2, according to in silico approach.	o-egcg	4-10	interleukin 1 alpha	Homo sapiens	106-110
35215890-8	2022	Additionally, the results show that the NF-kappaB inhibitor BAY11-7082 can inhibit the replication of ASFV and can inhibit IL-1beta and, IL-8 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	60-70	interleukin 1 alpha	Homo sapiens	123-131
35105497-10	2022	Psoriasis patients who used non-steroidal anti-inflammatory drugs or topical steroids had significantly lower GI, PD >= 4 mm (%), and saliva IL-1beta and TNF-alpha levels.	Steroids	77-85	interleukin 1 alpha	Homo sapiens	141-149
34099595-7	2022	LUA treatment dramatically reduced LPS-stimulated reactive oxygen species (ROS) and mRNA levels of pro-inflammatory mediators such as IL-1beta, IL-6, IL-8 and IFN-beta.	lua	0-3	interleukin 1 alpha	Homo sapiens	134-142
35005769-2	2022	However, whether IL-1beta affects hypoxic HUVECs by miR-24-3p is still unclear.	mir-24-3p	52-61	interleukin 1 alpha	Homo sapiens	17-25
35005769-11	2022	In addition, IL-1beta also significantly promotes the migration and invasion of hypoxic HUVECs; overexpression of miR-24-3p can partially rescue hypoxic HUVECs migration and invasion.	mir-24-3p	114-123	interleukin 1 alpha	Homo sapiens	13-21
35005769-14	2022	However, IL-1beta mediates suppression of miR-24-3p activity, leading to activation of the NKAP/NF-kappaB pathway.	mir-24-3p	42-51	interleukin 1 alpha	Homo sapiens	9-17
35005769-15	2022	In conclusion, our results reveal a new function of IL-1beta in suppressing miR-24-3p upregulation of the NKAP/NF-kB pathway.	mir-24-3p	76-85	interleukin 1 alpha	Homo sapiens	52-60
35088229-10	2022	Meanwhile, miR-128-3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients.	mir-128-3p	11-21	interleukin 1 alpha	Homo sapiens	115-123
35155408-6	2021	CTS stimulation upregulated collagen type I (COL1A1) expression, while IL-1beta significantly stimulated IL-6, IL-8, MMP-1, and MMP-3 gene expression and prostaglandin E2 production by AF cells but downregulated COL1A1.	Dinoprostone	154-170	interleukin 1 alpha	Homo sapiens	71-79
34818666-4	2022	IVSK reduced the secretion of inflammatory mediators, interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) and the mRNA expression of IL-6, IL-8, MCP-1 and IL-1beta.	ivsk	0-4	interleukin 1 alpha	Homo sapiens	169-177
35205267-7	2022	On the other hand, sBV or LPS administration increased cytokine expression, including IL-1beta, and showed synergistic cell death in combinatory treatment conditions.	SBV	19-22	interleukin 1 alpha	Homo sapiens	86-94
35164164-0	2022	Synthesis of DPIE (2-(1,2-Diphenyl-1H-indol-3-yl)ethanamine) Derivatives and Their Regulatory Effects on Pro-Inflammatory Cytokine Production in IL-1beta-Stimulated Primary Human Oral Cells.	dpie	13-17	interleukin 1 alpha	Homo sapiens	145-153
35169393-4	2022	Results: Compared with the control group, the level values of serum c-peptide, sICAM-1, and IL-1beta were significantly higher in the case group (P < 0.001), with CSVD being the dependent variable, and age, smoking, uric acid, history of stroke, serum c-peptide, sICAM-1, and IL-1beta being the independent variables.	Uric Acid	216-225	interleukin 1 alpha	Homo sapiens	92-100
34988564-8	2022	The postprandial level of pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) significantly increased at 3 h and 6 h after the HCMF meal intake when compared to the fasting state.	hcmf	133-137	interleukin 1 alpha	Homo sapiens	54-62
35164046-6	2022	In addition, the inhibitory effects of both doses of MiodesinTM (10 microg/mL and 200 microg/mL) resulted in reduced secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha) (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05) by VK2 E6/E7 cells.	miodesintm	53-63	interleukin 1 alpha	Homo sapiens	149-157
35164046-7	2022	In the same way, COX-1 MiodesinTM inhibited LPS-induced hyperactivation of KLE cells, as demonstrated by reduced secretion of IL-1beta, IL-6, IL-8, TNF-alpha (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05).	miodesintm	23-33	interleukin 1 alpha	Homo sapiens	126-134
35163148-8	2022	We found that sENG increased the gene expression of VEGF-A, pro-inflammatory cytokines/inflammasome mediators (TNF-alpha, IL-6, NLRP3, ASC, Caspase-1, and IL-1beta), and proteolytic enzyme (MMP-9) in BV2 microglia.	seng	14-18	interleukin 1 alpha	Homo sapiens	155-163
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Phorbol Esters	151-164	interleukin 1 alpha	Homo sapiens	285-293
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 alpha	Homo sapiens	285-293
35048417-6	2022	Analysis of cell culture medium of rifampicin treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumour necrosis factor (TNF) -alpha production.	Rifampin	35-45	interleukin 1 alpha	Homo sapiens	147-169
35048417-6	2022	Analysis of cell culture medium of rifampicin treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumour necrosis factor (TNF) -alpha production.	Rifampin	106-116	interleukin 1 alpha	Homo sapiens	147-169
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Paclitaxel	123-133	interleukin 1 alpha	Homo sapiens	208-217
35127599-20	2021	Secondary amyloidosis is still happening in adults however, it is extremely rare among children, presumably due to increased awareness, tight control, and the availability of anti-IL1 agents in colchicine-resistant cases.	Colchicine	194-204	interleukin 1 alpha	Homo sapiens	180-183
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Paclitaxel	172-182	interleukin 1 alpha	Homo sapiens	208-217
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Reactive Oxygen Species	267-290	interleukin 1 alpha	Homo sapiens	208-217
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Reactive Oxygen Species	292-295	interleukin 1 alpha	Homo sapiens	208-217
35111001-4	2021	In addition, elamipretide has been shown to attenuate neural oxidative stress (hydrogen peroxide, lipid peroxidation, and ROS), neuroinflammation (TNF, IL-6, COX-2, iNOS, NLRP3, cleaved caspase-1, IL-1beta, and IL-18), and toxic protein accumulation (Abeta).	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	13-25	interleukin 1 alpha	Homo sapiens	197-205
35059859-10	2022	Both treatments predicted activation of IFNgamma, IL1beta, TNF as upstream regulators, specially this effect was higher in dasatinib.	Dasatinib	123-132	interleukin 1 alpha	Homo sapiens	50-57
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Acetates	29-36	interleukin 1 alpha	Homo sapiens	73-81
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Propionates	38-48	interleukin 1 alpha	Homo sapiens	73-81
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Butyrates	54-62	interleukin 1 alpha	Homo sapiens	73-81
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Acetates	35-42	interleukin 1 alpha	Homo sapiens	140-148
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Propionates	44-54	interleukin 1 alpha	Homo sapiens	140-148
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Butyrates	60-68	interleukin 1 alpha	Homo sapiens	140-148
35056161-3	2022	Additionally, the effects of the most promising coumarin derivative (9f) in reversing the epithelial-to-mesenchymal transition (EMT) in IL-1beta-stimulated A549 cells and in inhibiting the EMT-associated migratory ability in A549 cells were also evaluated.	coumarin	48-56	interleukin 1 alpha	Homo sapiens	136-144
35095533-2	2021	Dimethyl itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1beta release from intestinal epithelial cells.	dimethyl itaconate	0-18	interleukin 1 alpha	Homo sapiens	95-103
35095533-2	2021	Dimethyl itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1beta release from intestinal epithelial cells.	dimethyl itaconate	20-22	interleukin 1 alpha	Homo sapiens	95-103
35087525-9	2021	VX-745, the p38 MAP kinase inhibitor significantly decreased IL-1beta- and LPS-induced pleckstrin levels at both the mRNA and the protein level.	VX-745	0-6	interleukin 1 alpha	Homo sapiens	61-69
35013099-9	2022	All three microbiota are closely related to IL-1beta and lipids (as an example, phosphoethanolamine (PEA)).	phosphorylethanolamine	80-99	interleukin 1 alpha	Homo sapiens	44-52
35083252-12	2021	The cytokines IL-1beta and GM-CSF decreased during 6 h of NMP.	N-methylpyrrolidone	58-61	interleukin 1 alpha	Homo sapiens	14-22
35013099-9	2022	All three microbiota are closely related to IL-1beta and lipids (as an example, phosphoethanolamine (PEA)).	phosphorylethanolamine	101-104	interleukin 1 alpha	Homo sapiens	44-52
35000611-4	2022	Recently it has been established that CCH can activate the inflammasome signaling pathways, involving NLRP3 and AIM2 inflammasomes that critically regulate IL-1beta production.	1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine	38-41	interleukin 1 alpha	Homo sapiens	156-164
34985729-11	2022	High concentrations of UA augmented LPS-stimulated IL-1beta transcript and protein levels as well as TNF-alpha protein levels in PBMC culture.	Uric Acid	23-25	interleukin 1 alpha	Homo sapiens	51-59
35011732-5	2022	In future, vitamin D and/or biotherapies targeting the IL1beta pathway may improve muscle wasting and subsequently CMBD, but this remains to be proven.	Vitamin D	11-20	interleukin 1 alpha	Homo sapiens	55-62
34874326-8	2022	ELISA assay was used to measure the effect of PPSR on attenuating the lipopolysaccharide (LPS) + Abeta-induced increase in IL-1beta.	UNII-042A8N37WH	97-102	interleukin 1 alpha	Homo sapiens	123-131
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Sitagliptin Phosphate	0-11	interleukin 1 alpha	Homo sapiens	93-101
34874326-11	2022	A further study revealed that PPSR attenuates the LPS+Abeta-induced increase in IL-1beta without affecting cell viability.	UNII-042A8N37WH	54-59	interleukin 1 alpha	Homo sapiens	80-88
34964706-4	2022	Mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (IL)-1beta and IL-18 by inhibiting the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia.	Mirtazapine	0-11	interleukin 1 alpha	Homo sapiens	84-106
34964706-4	2022	Mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (IL)-1beta and IL-18 by inhibiting the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia.	Isoflurane	22-32	interleukin 1 alpha	Homo sapiens	84-106
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Mercury	22-24	interleukin 1 alpha	Homo sapiens	93-101
34968169-0	2022	The protective effects of etomidate against interleukin-1beta (IL-1beta)-induced oxidative stress, extracellular matrix alteration and cellular senescence in chondrocytes.	Etomidate	26-35	interleukin 1 alpha	Homo sapiens	63-71
34967278-12	2022	Furthermore, PRRX1 deletion decreased TNF-alpha, IL-1beta and IL-6 levels in the DSS-challenged NCM460 cells, which were subjected to MMP13 overexpression.	Dextran Sulfate	81-84	interleukin 1 alpha	Homo sapiens	49-57
34968169-5	2022	Our results prove that etomidate ameliorated the IL-1beta-induced oxidative stress in C28/12 chondrocytes by decreasing and increasing the reactive oxygen species (ROS) and glutathione peroxidase (GPx) levels, respectively.	Etomidate	23-32	interleukin 1 alpha	Homo sapiens	49-57
34974796-8	2022	Results indicated that DEZ enhanced cell viability of HNPCs after IL-1beta exposure.	dezocine	23-26	interleukin 1 alpha	Homo sapiens	66-74
34968169-5	2022	Our results prove that etomidate ameliorated the IL-1beta-induced oxidative stress in C28/12 chondrocytes by decreasing and increasing the reactive oxygen species (ROS) and glutathione peroxidase (GPx) levels, respectively.	Reactive Oxygen Species	139-162	interleukin 1 alpha	Homo sapiens	49-57
34974796-10	2022	Moreover, DEZ notably inhibited IL-1beta-induced apoptosis of HNPCs.	dezocine	10-13	interleukin 1 alpha	Homo sapiens	32-40
34974796-13	2022	By contrast, PMA crippled the impacts of DEZ on inflammation, oxidative stress and apoptosis of HNPCs induced by IL-1beta.	dezocine	41-44	interleukin 1 alpha	Homo sapiens	113-121
34968169-5	2022	Our results prove that etomidate ameliorated the IL-1beta-induced oxidative stress in C28/12 chondrocytes by decreasing and increasing the reactive oxygen species (ROS) and glutathione peroxidase (GPx) levels, respectively.	Reactive Oxygen Species	164-167	interleukin 1 alpha	Homo sapiens	49-57
34974796-14	2022	Collectively, DEZ ameliorates IL-1beta-induced HNPCs injury via inhibiting MAPK signaling.	dezocine	14-17	interleukin 1 alpha	Homo sapiens	30-38
34968169-6	2022	Etomidate prevented the IL-1beta-induced increase in the expressions of matrix metalloproteinase-3 (MMP-3) and matrix metalloproteinase-13 (MMP-13) in C28/I2 chondrocytes at both mRNA and protein levels.	Etomidate	0-9	interleukin 1 alpha	Homo sapiens	24-32
34968169-8	2022	The expression levels of senescence regulators, plasminogen activator inhibitor-1 (PAI-1) and p16, were also inhibited by etomidate in IL-1beta-treated C28/I2 chondrocytes.	Etomidate	122-131	interleukin 1 alpha	Homo sapiens	135-143
34968169-10	2022	Moreover, blockage of AMPK using compound C abolished the protective effects of etomidate on IL-1beta-challenged C28/I2 chondrocytes.	Etomidate	80-89	interleukin 1 alpha	Homo sapiens	93-101
34968169-11	2022	Taken together, these results demonstrate that etomidate protected C28/I2 chondrocytes from IL-1beta-induced oxidative stress, ECM degradation, and cellular senescence via activating AMPK signaling.	Etomidate	47-56	interleukin 1 alpha	Homo sapiens	92-100
34843183-12	2022	In macrophages in vitro, spironolactone suppressed lipopolysaccharide (LPS)-induced TNF-alpha, IL-6, IL-1beta and IL-10 levels.	Spironolactone	25-39	interleukin 1 alpha	Homo sapiens	101-109
34990303-5	2022	miR-128-3p overexpression or ZEB1 silencing attenuated extracellular matrix degradation and cell apoptosis, and increased the proliferation of IL-1beta-activated CHON-001 cells.	mir-128-3p	0-10	interleukin 1 alpha	Homo sapiens	143-151
35431536-10	2022	Hence, suPAR levels which measures IL-1alpha (necroptosis) and S100A8/A9 (neutrophil migration) can perhaps be a good early biomarker predicting the disease progression.	supar	7-12	interleukin 1 alpha	Homo sapiens	35-44
35213000-7	2022	Next, to investigate the crosstalks between KCs and hepatocytes in the context of inflammasome activation, isolated KCs were activated with lipopolysaccharide (LPS), alone or in tandem with ATP, which resulted in inflammasome activation in KCs evident by abundant IL-1beta secretion.	Adenosine Triphosphate	190-193	interleukin 1 alpha	Homo sapiens	264-272
35237974-5	2022	Importantly, activation of the nucleotide oligomerization domain leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome activates the caspase-1 protease and results in the generation and release of potent pro-inflammatory cytokines, IL-1beta and IL-18.	Leucine	65-72	interleukin 1 alpha	Homo sapiens	257-265
35140567-6	2022	The main outcome measures include changes in the IL-1 mRNA expression between the triamcinolone, bevacizumab, and placebo groups.	Triamcinolone	82-95	interleukin 1 alpha	Homo sapiens	49-53
35140567-3	2022	This study aims to analyse the expression of IL-1 after the injection of triamcinolone and bevacizumab subconjunctiva.	Triamcinolone	73-86	interleukin 1 alpha	Homo sapiens	45-49
35140567-8	2022	The changes in blood levels of mRNA IL-1 expression are as follows: 4.81 +- 0.52 in the bevacizumab group, 3.40 +- 2.63 in the triamcinolone group, and 1.08 +- 1.48 in the placebo group (p = 0.04).	Triamcinolone	127-140	interleukin 1 alpha	Homo sapiens	36-40
35355720-9	2022	There was a significant association of resveratrol with the levels of blood glucose (BG), serum creatinine (Scr), blood urea nitrogen (BUN), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), and interleukin-1beta (IL-1beta).	Resveratrol	39-50	interleukin 1 alpha	Homo sapiens	280-288
35355720-13	2022	With regard to pro-inflammatory cytokines, resveratrol had a positive effect on the reduction of IL-1beta.	Resveratrol	43-54	interleukin 1 alpha	Homo sapiens	97-105
2533500-2	1989	Two-dimensional polyacrylamide-gel electrophoresis revealed that the internalized 125I-IL1 alpha associated with the nucleus was intact, with negligible breakdown products present.	polyacrylamide	16-30	interleukin 1 alpha	Homo sapiens	87-96
35090964-3	2022	Moreover, apoptosis and inflammatory response were promoted after the co-exposure of ZEA and DON, indicated by the increased expression of BAX, Caspase-3, IL-1beta and IL-6 genes.	deoxynivalenol	93-96	interleukin 1 alpha	Homo sapiens	155-163
2557044-8	1989	However, we found that cycloheximide, when added to synovial fibroblast cultures up to 6 hours after treatment with IL-1, inhibited the expression of collagenase mRNA.	Cycloheximide	23-36	interleukin 1 alpha	Homo sapiens	116-120
2592770-0	1989	Blockade of prostaglandin biosynthesis in intact mice dramatically augments the expansion of committed myeloid progenitor cells (colony-forming units-granulocyte, macrophage) after acute administration of recombinant human IL-1 alpha.	Prostaglandins	12-25	interleukin 1 alpha	Homo sapiens	223-233
2553311-0	1989	Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin 1 and reactive oxygen species in inflamed sites.	Superoxides	114-130	interleukin 1 alpha	Homo sapiens	14-27
2553311-0	1989	Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin 1 and reactive oxygen species in inflamed sites.	Reactive Oxygen Species	162-185	interleukin 1 alpha	Homo sapiens	14-27
2553311-3	1989	O2-, but not H2O2, could induce an IL-1-like factor(s) from monocytes and PMNs.	Superoxides	0-2	interleukin 1 alpha	Homo sapiens	35-39
2553311-4	1989	IL-1-like activity from monocytes and PMNs induced by O2- was due to de novo synthesis because no IL-1-like activity was found in culture supernatants and in the lysate of unstimulated cells.	Superoxides	54-56	interleukin 1 alpha	Homo sapiens	0-4
2553311-6	1989	Generation of IL-1-like activity from monocytes was amplified by preincubation with catalase (H2O2 scavenger), although it was suppressed by preincubation with either superoxide dismutase (O2- scavenger) or vitamin E (antioxidant analogs).	Hydrogen Peroxide	94-98	interleukin 1 alpha	Homo sapiens	14-18
2553311-6	1989	Generation of IL-1-like activity from monocytes was amplified by preincubation with catalase (H2O2 scavenger), although it was suppressed by preincubation with either superoxide dismutase (O2- scavenger) or vitamin E (antioxidant analogs).	Vitamin E	207-216	interleukin 1 alpha	Homo sapiens	14-18
2553311-7	1989	These results suggest that production of an IL-1-like factor(s) from monocytes and PMNs was due to O2- stimulation.	Superoxides	99-101	interleukin 1 alpha	Homo sapiens	44-48
2553311-8	1989	Our data that production of an IL-1-like factor(s) from inflammatory cells by stimulation with O2- imply a model of the up-regulation mechanism of inflammation mediated by enhanced IL-1-like factor production stimulated with reactive oxygen species.	Reactive Oxygen Species	225-248	interleukin 1 alpha	Homo sapiens	31-35
2553311-8	1989	Our data that production of an IL-1-like factor(s) from inflammatory cells by stimulation with O2- imply a model of the up-regulation mechanism of inflammation mediated by enhanced IL-1-like factor production stimulated with reactive oxygen species.	Reactive Oxygen Species	225-248	interleukin 1 alpha	Homo sapiens	181-185
2685478-1	1989	Injection of a single dose of recombinant human interleukin-1 alpha (r-hu-IL-1 alpha) into mice 24 hr after 5-fluorouracil (FU) treatment resulted in an increased rate of recovery of three types of colony-forming cells (CFCs) in the bone marrow.	Fluorouracil	108-122	interleukin 1 alpha	Homo sapiens	48-67
2804984-0	1989	31P-nuclear magnetic resonance studies of the effect of recombinant human interleukin 1 alpha on the bioenergetics of RIF-1 tumors.	ET bromodomain inhibitor	0-3	interleukin 1 alpha	Homo sapiens	74-93
2592817-1	1989	To investigate the correlation between chorioamnionitis and premature rupture of membranes (PROM), the influence of human recombinant interleukin-1 alpha (hrIL-1) on the metabolism of glycosaminoglycans (GAGs) and collagen in cultured human chorionic cells was examined and the following results were obtained.	Glycosaminoglycans	184-202	interleukin 1 alpha	Homo sapiens	134-153
2592817-13	1989	The stimulatory effects of IL-1 on the biosynthesis of hyaluronic acid and collagenase are connected with the decrease in tensile strength observed in PROM.	Hyaluronic Acid	55-70	interleukin 1 alpha	Homo sapiens	27-31
2484023-0	1989	Induction of membrane-associated interleukin 1 alpha (IL-1 alpha) by synergistic activation of human blood monocytes with interferon gamma and muramyl dipeptide analog.	Dipeptides	151-160	interleukin 1 alpha	Homo sapiens	54-64
2484023-2	1989	When monocytes were treated with norMDP or lipopolysaccharide (LPS) for 16 hr, they released IL-1 into their culture supernatant.	N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine	33-39	interleukin 1 alpha	Homo sapiens	93-97
2484023-3	1989	When these activated monocytes were fixed with paraformaldehyde (PFA), they stimulated blastogenic responses of C3H/HeJ mouse thymocytes to PHA, suggesting that membrane-associated IL-1 could be induced by norMDP or LPS.	paraform	47-63	interleukin 1 alpha	Homo sapiens	181-185
2484023-3	1989	When these activated monocytes were fixed with paraformaldehyde (PFA), they stimulated blastogenic responses of C3H/HeJ mouse thymocytes to PHA, suggesting that membrane-associated IL-1 could be induced by norMDP or LPS.	paraform	65-68	interleukin 1 alpha	Homo sapiens	181-185
2484023-4	1989	Membrane-associated IL-1 was also found to be induced by the synergistic actions of suboptimal concentrations of rIFN-gamma and nor MDP, but not of rIFN-alpha A or rIFN-beta with norMDP.	Acetylmuramyl-Alanyl-Isoglutamine	132-135	interleukin 1 alpha	Homo sapiens	20-24
2484023-4	1989	Membrane-associated IL-1 was also found to be induced by the synergistic actions of suboptimal concentrations of rIFN-gamma and nor MDP, but not of rIFN-alpha A or rIFN-beta with norMDP.	rifn-alpha a	148-160	interleukin 1 alpha	Homo sapiens	20-24
2686646-1	1989	The role of calcium in interleukin- (IL) 8-, IL-1 alpha- and IL-1 beta-induced lymphocyte migration has been investigated by using the calcium channel antagonists, verapamil, nifedipine, diltiazem (IL-8) and the optical isomers of the dihydropyridine analogue SDZ 202-791 (IL-8, IL-1 alpha and IL-1 beta).	Calcium	12-19	interleukin 1 alpha	Homo sapiens	45-55
2583859-9	1989	Thus, TAM exhibit a dissociation in their capacity to release the functionally related monokines IL-1 and IL-6.	tam	6-9	interleukin 1 alpha	Homo sapiens	97-101
2511437-9	1989	Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor.	Phorbol Esters	149-162	interleukin 1 alpha	Homo sapiens	198-208
2511437-9	1989	Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor.	Colforsin	170-179	interleukin 1 alpha	Homo sapiens	198-208
2636983-0	1989	Cis-urocanic acid stereospecifically modulates human monocyte IL-1 production and surface HLA-DR antigen expression, T-cell IL-2 production and CD4/CD8 ratio.	cis-Urocanic acid	0-17	interleukin 1 alpha	Homo sapiens	62-66
2636983-2	1989	We have earlier shown that cis-UCA suppresses interleukin 1 (IL-1) production in human epidermal cells.	cis-Urocanic acid	27-34	interleukin 1 alpha	Homo sapiens	61-65
2636983-4	1989	Cis-UCA (100 micrograms/ml) caused a significant downregulation of monocyte IL-1 production, and diminished monocyte HLA-DR expression.	cis-Urocanic acid	0-7	interleukin 1 alpha	Homo sapiens	76-80
2534450-5	1989	A relationship was found between KS in the exudate and the interleukin-1 level in the exudate.	ks	33-35	interleukin 1 alpha	Homo sapiens	59-72
2804984-5	1989	Tumor blood flow, estimated by 86RbCl uptake, decreased within 30 min after IL-1 alpha treatment.	86rbcl	31-37	interleukin 1 alpha	Homo sapiens	76-86
2817905-0	1989	Characterization of the tryptophan environments of interleukins 1 alpha and 1 beta by fluorescence quenching and lifetime measurements.	Tryptophan	24-34	interleukin 1 alpha	Homo sapiens	51-82
2817905-1	1989	The tryptophan environments of interleukins 1 alpha and 1 beta, immunomodulatory proteins with similar biological activities but only 25% sequence homology, were characterized by steady-state and dynamic fluorescence measurements.	Tryptophan	4-14	interleukin 1 alpha	Homo sapiens	31-62
2556902-6	1989	PGE2 synthesis in synovial cells was increased when arachidonic acid or interleukin-1 was added to the culture, whereas LTB4 production remained unaltered.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	72-85
2817905-6	1989	Taken together with the results of steady-state measurements, we suggest that the single tryptophan of IL-1 beta is statically quenched by neighboring charged residues, whereas the tryptophan fluorescence of IL-1 alpha is unaffected by ionic strength, and that the tryptophans of the two proteins have different accessibilities to ionic quenchers.	Tryptophan	181-191	interleukin 1 alpha	Homo sapiens	208-218
2513105-0	1989	Interleukin-1 potentiates antigen-mediated arachidonic acid metabolite formation in mast cells.	Arachidonic Acid	43-59	interleukin 1 alpha	Homo sapiens	0-13
2512925-0	1989	Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release.	Diclofenac	22-32	interleukin 1 alpha	Homo sapiens	53-66
2512925-0	1989	Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release.	Indomethacin	37-49	interleukin 1 alpha	Homo sapiens	53-66
2512925-0	1989	Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release.	Dinoprostone	86-90	interleukin 1 alpha	Homo sapiens	53-66
2512925-2	1989	The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated.	Diclofenac	78-88	interleukin 1 alpha	Homo sapiens	110-123
2512925-2	1989	The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated.	Indomethacin	93-105	interleukin 1 alpha	Homo sapiens	110-123
2512925-2	1989	The inhibitory effects of two non-steroidal anti-inflammatory drugs (NSAIDS), diclofenac and indomethacin, on interleukin-1 (IL-1)-induced changes in arachidonic acid (AA) release and prostaglandin E2(PGE2) production by human synovial cells was investigated.	Arachidonic Acid	150-166	interleukin 1 alpha	Homo sapiens	110-123
2512925-3	1989	Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively.	Diclofenac	5-15	interleukin 1 alpha	Homo sapiens	52-62
2512925-3	1989	Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively.	Indomethacin	20-32	interleukin 1 alpha	Homo sapiens	52-62
2512925-3	1989	Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively.	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	52-62
2512925-8	1989	These results suggest that whilst at nanomolar concentrations, diclofenac and indomethacin can inhibit IL-1 alpha-induced PGE2 output, at micromolar concentrations an effect on free AA levels is also evident.	Diclofenac	63-73	interleukin 1 alpha	Homo sapiens	103-113
2512925-8	1989	These results suggest that whilst at nanomolar concentrations, diclofenac and indomethacin can inhibit IL-1 alpha-induced PGE2 output, at micromolar concentrations an effect on free AA levels is also evident.	Indomethacin	78-90	interleukin 1 alpha	Homo sapiens	103-113
2513105-8	1989	Inhibitors of arachidonic acid metabolic pathways prevented the release of LTC4 and PGD2 from mast cells activated with antigen and IL-1.	Arachidonic Acid	14-30	interleukin 1 alpha	Homo sapiens	132-136
2512925-8	1989	These results suggest that whilst at nanomolar concentrations, diclofenac and indomethacin can inhibit IL-1 alpha-induced PGE2 output, at micromolar concentrations an effect on free AA levels is also evident.	Dinoprostone	122-126	interleukin 1 alpha	Homo sapiens	103-113
2509610-11	1989	PBMC cultured with LPS and latex beads in the absence of serum released 30-40K Mr IL-1 alpha, as well as 17K Mr IL-1 alpha and 17K Mr IL-1 beta.	lps	19-22	interleukin 1 alpha	Homo sapiens	82-92
2806435-2	1989	We have recently reported that IL-1 can provide protection for human bone marrow colony-forming cells including blast colony-forming cells (B1-CFC) treated with high doses of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	175-204	interleukin 1 alpha	Homo sapiens	31-35
2806435-2	1989	We have recently reported that IL-1 can provide protection for human bone marrow colony-forming cells including blast colony-forming cells (B1-CFC) treated with high doses of 4-hydroperoxycyclophosphamide (4-HC).	perfosfamide	206-210	interleukin 1 alpha	Homo sapiens	31-35
2697794-6	1989	Low activity of interleukin-1, decreased level of interferon-alpha and almost normal level of gamma-interferon were found in patients with progressive course of hydatid disease with the lowering of these parameters after mebendazole therapy.	Mebendazole	221-232	interleukin 1 alpha	Homo sapiens	16-29
2600954-0	1989	Pulse methylprednisolone therapy reduces monocyte IL-1 production ex vivo.	Methylprednisolone	6-24	interleukin 1 alpha	Homo sapiens	50-54
2553837-3	1989	Since both tumor necrosis factor alpha (TNF alpha) and interleukin 1 (IL-1), which are secreted by monocytes, can stimulate endothelial cells to produce granulocyte-macrophage colony-stimulating factor (GM-CSF), we determined whether lithium-stimulated monocytes produced TNF alpha and/or IL-1.	Lithium	234-241	interleukin 1 alpha	Homo sapiens	55-74
2553837-3	1989	Since both tumor necrosis factor alpha (TNF alpha) and interleukin 1 (IL-1), which are secreted by monocytes, can stimulate endothelial cells to produce granulocyte-macrophage colony-stimulating factor (GM-CSF), we determined whether lithium-stimulated monocytes produced TNF alpha and/or IL-1.	Lithium	234-241	interleukin 1 alpha	Homo sapiens	70-74
2814818-6	1989	The production of both interleukins correlated negatively with serum total bilirubin level (IL-1 r = -0.478, p less than 0.05; IL-2: r = -0.482, p less than 0.05) and positively with high-density lipoprotein cholesterol in serum (IL-1: r = 0.505, p less than 0.01; IL-2: r = 0.494, p less than 0.05).	Bilirubin	75-84	interleukin 1 alpha	Homo sapiens	92-96
2813453-4	1989	We report here the ability of recombinant human IL-1 alpha to protect normal murine hematopoietic progenitors (CFU-GM, BFU-E, and CFU-Meg) from the toxic effects of AZT.	Zidovudine	165-168	interleukin 1 alpha	Homo sapiens	48-58
2602660-5	1989	Intraperitoneal injection of human recombinant interleukin-1 alpha induced intraperitoneal accumulation of hyaluronic acid and its production by mesenterium.	Hyaluronic Acid	107-122	interleukin 1 alpha	Homo sapiens	47-66
2694696-0	1989	[Interleukin-1-inducing activity of the polysaccharide-containing antigens of the cell wall in Yersinia pestis].	Polysaccharides	40-54	interleukin 1 alpha	Homo sapiens	1-14
2550484-3	1989	Simultaneous addition of tumor necrosis factor and interleukin 1 synergistically stimulated prostaglandin synthesis, even when both growth factors were added at what would be supramaximal concentrations by themselves.	Prostaglandins	92-105	interleukin 1 alpha	Homo sapiens	51-64
2804117-3	1989	In the presence of IL-1, both 35S-proteoglycan monomers and aggregates were lost, suggesting that IL-1 increases the susceptibility of aggregates to loss from the cartilage matrix.	Sulfur-35	30-33	interleukin 1 alpha	Homo sapiens	19-23
2804117-3	1989	In the presence of IL-1, both 35S-proteoglycan monomers and aggregates were lost, suggesting that IL-1 increases the susceptibility of aggregates to loss from the cartilage matrix.	Sulfur-35	30-33	interleukin 1 alpha	Homo sapiens	98-102
2804117-4	1989	Evaluation of uronic acid as a measure of net change in proteoglycan content indicated that IL-1 causes a net decrease in both monomers and aggregates.	Uronic Acids	14-25	interleukin 1 alpha	Homo sapiens	92-96
2804117-6	1989	Incorporation of [35S]sulfate into cartilage proteoglycans following exposure to IL-1 showed that synthesis of monomers and aggregates is inhibited similarly.	35s]sulfate	18-29	interleukin 1 alpha	Homo sapiens	81-85
2507377-0	1989	Interleukin 1-induced prostaglandin E2 accumulation by isolated pancreatic islets.	Dinoprostone	22-38	interleukin 1 alpha	Homo sapiens	0-13
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Dinoprostone	70-86	interleukin 1 alpha	Homo sapiens	18-37
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Dinoprostone	70-86	interleukin 1 alpha	Homo sapiens	39-43
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Dinoprostone	88-92	interleukin 1 alpha	Homo sapiens	18-37
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Dinoprostone	88-92	interleukin 1 alpha	Homo sapiens	39-43
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Glucose	210-217	interleukin 1 alpha	Homo sapiens	18-37
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Glucose	210-217	interleukin 1 alpha	Homo sapiens	39-43
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Glucose	254-261	interleukin 1 alpha	Homo sapiens	18-37
2507377-1	1989	Recombinant human interleukin 1 alpha (IL-1) has been found to induce prostaglandin E2 (PGE2) accumulation by isolated rat islets of Langerhans at concentrations similar to those at which the cytokine inhibits glucose-induced insulin secretion and islet glucose oxidation.	Glucose	254-261	interleukin 1 alpha	Homo sapiens	39-43
2507377-2	1989	Maximal stimulation of PGE2 accumulation (5 times control value) occurred at 200 pM IL-1, and half-maximal stimulation occurred at 25 pM IL-1.	Dinoprostone	23-27	interleukin 1 alpha	Homo sapiens	84-88
2507377-3	1989	Significant augmentation of PGE2 accumulation by IL-1 required 10-18 h of exposure to the cytokine.	Dinoprostone	28-32	interleukin 1 alpha	Homo sapiens	49-53
2507377-4	1989	Islets that had been pretreated with IL-1 for 18 h showed elevated rates of PGE2 production at basal (3-mM) and stimulatory (16.5-mM) glucose concentrations and converted exogenous arachidonic acid to PGE2 at twice the maximal rate of control islets.	Dinoprostone	76-80	interleukin 1 alpha	Homo sapiens	37-41
2507377-4	1989	Islets that had been pretreated with IL-1 for 18 h showed elevated rates of PGE2 production at basal (3-mM) and stimulatory (16.5-mM) glucose concentrations and converted exogenous arachidonic acid to PGE2 at twice the maximal rate of control islets.	Glucose	134-141	interleukin 1 alpha	Homo sapiens	37-41
2507377-4	1989	Islets that had been pretreated with IL-1 for 18 h showed elevated rates of PGE2 production at basal (3-mM) and stimulatory (16.5-mM) glucose concentrations and converted exogenous arachidonic acid to PGE2 at twice the maximal rate of control islets.	Arachidonic Acid	181-197	interleukin 1 alpha	Homo sapiens	37-41
2507377-4	1989	Islets that had been pretreated with IL-1 for 18 h showed elevated rates of PGE2 production at basal (3-mM) and stimulatory (16.5-mM) glucose concentrations and converted exogenous arachidonic acid to PGE2 at twice the maximal rate of control islets.	Dinoprostone	201-205	interleukin 1 alpha	Homo sapiens	37-41
2556998-0	1989	Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha.	Reactive Oxygen Species	26-49	interleukin 1 alpha	Homo sapiens	65-110
2556998-1	1989	Human fibroblasts in primary culture released reactive oxygen species upon stimulation with cytokines such as interleukin-1 alpha (IL-1) or tumour necrosis factor-alpha (TNF).	Reactive Oxygen Species	46-69	interleukin 1 alpha	Homo sapiens	110-129
2556998-1	1989	Human fibroblasts in primary culture released reactive oxygen species upon stimulation with cytokines such as interleukin-1 alpha (IL-1) or tumour necrosis factor-alpha (TNF).	Reactive Oxygen Species	46-69	interleukin 1 alpha	Homo sapiens	131-135
2800921-6	1989	Both interleukin 1 alpha and beta inhibited TSH-induced thyroid peroxidase mRNA in a dose responsive manner; 10(3) U/1 interleukin 1 caused maximal suppression of TSH-induced thyroid peroxidase mRNA level to nearly basal levels.	Thyrotropin	44-47	interleukin 1 alpha	Homo sapiens	5-24
2800921-6	1989	Both interleukin 1 alpha and beta inhibited TSH-induced thyroid peroxidase mRNA in a dose responsive manner; 10(3) U/1 interleukin 1 caused maximal suppression of TSH-induced thyroid peroxidase mRNA level to nearly basal levels.	Thyrotropin	44-47	interleukin 1 alpha	Homo sapiens	5-18
2800921-6	1989	Both interleukin 1 alpha and beta inhibited TSH-induced thyroid peroxidase mRNA in a dose responsive manner; 10(3) U/1 interleukin 1 caused maximal suppression of TSH-induced thyroid peroxidase mRNA level to nearly basal levels.	Thyrotropin	163-166	interleukin 1 alpha	Homo sapiens	5-24
2800921-6	1989	Both interleukin 1 alpha and beta inhibited TSH-induced thyroid peroxidase mRNA in a dose responsive manner; 10(3) U/1 interleukin 1 caused maximal suppression of TSH-induced thyroid peroxidase mRNA level to nearly basal levels.	Thyrotropin	163-166	interleukin 1 alpha	Homo sapiens	5-18
2800921-7	1989	Interleukin 1 also inhibited cAMP analogue 8-bromo-cyclic AMP induced thyroid peroxidase mRNA level.	Cyclic AMP	29-33	interleukin 1 alpha	Homo sapiens	0-13
2800921-7	1989	Interleukin 1 also inhibited cAMP analogue 8-bromo-cyclic AMP induced thyroid peroxidase mRNA level.	8-Bromo Cyclic Adenosine Monophosphate	43-61	interleukin 1 alpha	Homo sapiens	0-13
2800921-9	1989	These results demonstrate that interleukin 1 directly inhibits TSH-induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis.	Thyrotropin	63-66	interleukin 1 alpha	Homo sapiens	31-44
2800921-9	1989	These results demonstrate that interleukin 1 directly inhibits TSH-induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis.	Thyrotropin	63-66	interleukin 1 alpha	Homo sapiens	163-176
2676016-2	1989	In this study, endotoxin-depleted, purified iron-saturated human Lf was assessed for its effect on the production of interleukin-1 by cultured monocytes and their subsequent effect on colony-stimulating factor release from cultured fibroblasts.	Iron	44-48	interleukin 1 alpha	Homo sapiens	117-130
2676016-6	1989	Antibody to Lf completely abrogated the suppressive effects observed with Lf, whereas antibody to IL-1 ablated the induction by monocyte-conditioned medium of CSA release by fibroblasts.	Cyclosporine	159-162	interleukin 1 alpha	Homo sapiens	98-102
2676016-10	1989	We conclude that the inhibition of GM-CSA production/release by Lf is mediated through inhibition of the synthesis/release of IL-1 by mononuclear phagocytes.	gm-csa	35-41	interleukin 1 alpha	Homo sapiens	126-130
2676016-11	1989	This inhibition of IL-1 prevents accessory cells from producing and/or releasing GM-CSA.	gm-csa	81-87	interleukin 1 alpha	Homo sapiens	19-23
2816517-1	1989	Transforming growth factor alpha (TGF-alpha) and interleukin-1 (IL-1) have been shown to affect bone metabolism in vitro by prostaglandin-dependent and PG-independent mechanisms.	Prostaglandins	124-137	interleukin 1 alpha	Homo sapiens	64-68
2816517-1	1989	Transforming growth factor alpha (TGF-alpha) and interleukin-1 (IL-1) have been shown to affect bone metabolism in vitro by prostaglandin-dependent and PG-independent mechanisms.	Prostaglandins	152-154	interleukin 1 alpha	Homo sapiens	64-68
2816517-5	1989	The enhanced inhibitory effect of TGF-alpha plus IL-1 on collagen synthesis was associated with a synergistic increase in prostaglandin accumulation in the medium.	Prostaglandins	122-135	interleukin 1 alpha	Homo sapiens	49-53
2816517-6	1989	Addition of indomethacin blocked PGE2 accumulation and partially reversed the inhibitory effect of TGF-alpha alone or in combination with IL-1 on collagen synthesis.	Indomethacin	12-24	interleukin 1 alpha	Homo sapiens	138-142
2816517-8	1989	Our results show that TGF-alpha and IL-1, which are both produced by certain tumors as well as activated macrophages, appear to act synergistically to increase prostaglandin synthesis and inhibit collagen synthesis in vitro.	Prostaglandins	160-173	interleukin 1 alpha	Homo sapiens	36-40
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Formaldehyde	156-164	interleukin 1 alpha	Homo sapiens	107-117
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Paraffin	171-179	interleukin 1 alpha	Homo sapiens	107-117
2789325-6	1989	PBMNC spontaneously produced low levels of IL-1 beta and IL-6 that were augmented by the addition of hr IL-1 alpha.	pbmnc	0-5	interleukin 1 alpha	Homo sapiens	104-114
2476485-0	1989	Recombinant human IL-1 alpha and -1 beta potentiate IgE-mediated histamine release from human basophils.	Histamine	65-74	interleukin 1 alpha	Homo sapiens	18-40
2508093-4	1989	Treatment of the cells with human-recombinant interleukin 1 (IL-1), phorbol 12-myristate 13-acetate, or heparin-binding growth factor 1 enhanced the expression of APP gene in these cells, but calcium ionophore A23187 and dexamethasone did not.	Calcium	192-199	interleukin 1 alpha	Homo sapiens	46-65
2508093-4	1989	Treatment of the cells with human-recombinant interleukin 1 (IL-1), phorbol 12-myristate 13-acetate, or heparin-binding growth factor 1 enhanced the expression of APP gene in these cells, but calcium ionophore A23187 and dexamethasone did not.	Dexamethasone	221-234	interleukin 1 alpha	Homo sapiens	46-65
2508093-5	1989	The protein kinase C inhibitor 1-(isoquinolinsulfonyl)-2-methylpiperazine (H7) inhibited IL-1-mediated increase of the level of APP transcripts.	1-(isoquinolinsulfonyl)-2-methylpiperazine	31-73	interleukin 1 alpha	Homo sapiens	89-93
2508093-5	1989	The protein kinase C inhibitor 1-(isoquinolinsulfonyl)-2-methylpiperazine (H7) inhibited IL-1-mediated increase of the level of APP transcripts.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	75-77	interleukin 1 alpha	Homo sapiens	89-93
2506272-1	1989	Both IL-1 alpha and IL-1 beta and TNF-alpha induced a time- and dose-dependent release of authentic PGE2 from cultured human glomerular mesangial cells (HMC).	Dinoprostone	100-104	interleukin 1 alpha	Homo sapiens	5-15
2788136-11	1989	Purified C. trachomatis lipopolysaccharide was also an effective IL-1 inducer, suggesting that the response to intact organisms may be largely a response to chlamydial lipopolysaccharide.	chlamydial lipopolysaccharide	157-186	interleukin 1 alpha	Homo sapiens	65-69
2528548-0	1989	Generation of IL-1-like activity in response to biomedical polymer implants: a comparison of in vitro and in vivo models.	Polymers	59-66	interleukin 1 alpha	Homo sapiens	14-18
2528548-4	1989	The polymers tested induce the production of the regulatory inflammatory protein interleukin 1 as well as a factor that enhances fibroblast proliferation and collagen synthesis.	Polymers	4-12	interleukin 1 alpha	Homo sapiens	81-94
2507640-1	1989	This study examined the secretion of IL-1 alpha and IL-1 beta by THP-1 leukemia cells following activation with mezerein and promotion of synthesis by interferon (IFN-gamma).	mezerein	112-120	interleukin 1 alpha	Homo sapiens	37-47
2527267-8	1989	SLE B cells expressed large number of IL-1R detected by FITC-conjugated IL-1 alpha.	Fluorescein-5-isothiocyanate	56-60	interleukin 1 alpha	Homo sapiens	72-82
2507640-8	1989	Cell blotting showed that a greater proportion of attached cells incubated for 24 h in medium containing mezerein and IFN-gamma secreted IL-1 than cells in control medium.	mezerein	105-113	interleukin 1 alpha	Homo sapiens	137-141
2549546-8	1989	The effects of interleukin 1 and tumor necrosis factor on intracellular cAMP accumulation may be a model for immune modulation of other cellular functions dependent upon cyclic nucleotide metabolism.	Cyclic AMP	72-76	interleukin 1 alpha	Homo sapiens	15-54
2554066-5	1989	Inhibition of phospholipase A2 activity ameliorated the IL-1 stimulated inflammation; treatment with 10 mg/kg dexamethaxone eliminated approximately 80% of increased myeloperoxidase activity compared to control values.	dexamethaxone	110-123	interleukin 1 alpha	Homo sapiens	56-60
2554066-6	1989	This model provides a well-defined in vivo assay with which to quantify the systemic effects of compounds capable of altering the activity of IL-1, and the data suggest that this mechanism may explain the unique efficacy of steroids as antiinflammatories.	Steroids	224-232	interleukin 1 alpha	Homo sapiens	142-146
2520772-3	1989	This report concerns specific binding sites for muramyl peptide in preparations of brain tissue, interaction between muramyl peptide and serotonin in binding to glial-derived cells, and the ability of both muramyl peptide and serotonin to induce release of interleukin-1-like activity from these cells.	Serotonin	226-235	interleukin 1 alpha	Homo sapiens	257-270
2520772-8	1989	We found that low-nanomolar concentrations of either muramyl peptide or serotonin rapidly induced release of interleukin-1-like activity from a glial cell line.	Serotonin	72-81	interleukin 1 alpha	Homo sapiens	109-122
2549546-8	1989	The effects of interleukin 1 and tumor necrosis factor on intracellular cAMP accumulation may be a model for immune modulation of other cellular functions dependent upon cyclic nucleotide metabolism.	Nucleotides, Cyclic	170-187	interleukin 1 alpha	Homo sapiens	15-54
2665849-2	1989	IL-1 stimulated tritiated thymidine (3H-TdR) uptake of AML cells in 13 of 28 cases.	Tritiated thymidine	16-35	interleukin 1 alpha	Homo sapiens	0-4
2665849-4	1989	Most likely, IL-1 exerted these stimulative effects directly on AML blast cells because IL-1 effectively induced 3H-TdR uptake of CD34-positive AML blasts (separated following cell sorting).	Tritium	113-115	interleukin 1 alpha	Homo sapiens	13-17
2665849-4	1989	Most likely, IL-1 exerted these stimulative effects directly on AML blast cells because IL-1 effectively induced 3H-TdR uptake of CD34-positive AML blasts (separated following cell sorting).	Tritium	113-115	interleukin 1 alpha	Homo sapiens	88-92
2789072-0	1989	Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1.	Diclofenac	10-20	interleukin 1 alpha	Homo sapiens	117-130
2666106-12	1989	The oxidation of D-[6-14C]glucose and L-[U-14C]leucine were decreased by 50% in IL-1-treated islets.	d-[6-14c]glucose	17-33	interleukin 1 alpha	Homo sapiens	80-84
2789072-0	1989	Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1.	Prostaglandins E	24-39	interleukin 1 alpha	Homo sapiens	117-130
2789072-0	1989	Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1.	Hyaluronic Acid	44-59	interleukin 1 alpha	Homo sapiens	117-130
2666106-12	1989	The oxidation of D-[6-14C]glucose and L-[U-14C]leucine were decreased by 50% in IL-1-treated islets.	l-[u-14c]leucine	38-54	interleukin 1 alpha	Homo sapiens	80-84
2666106-14	1989	However, in the presence of IL-1 there was a significant increase in L-[U-14C]glutamate oxidation.	l-[u-14c]glutamate	69-87	interleukin 1 alpha	Homo sapiens	28-32
2787741-1	1989	Very recently, it has been reported that interleukin-1 (IL-1) has an inhibitory effect on progesterone production by porcine granulosa cells in vitro.	Progesterone	90-102	interleukin 1 alpha	Homo sapiens	41-54
2787741-1	1989	Very recently, it has been reported that interleukin-1 (IL-1) has an inhibitory effect on progesterone production by porcine granulosa cells in vitro.	Progesterone	90-102	interleukin 1 alpha	Homo sapiens	56-60
2666106-15	1989	These combined observations suggest that exposure to IL-1 induces a preferential decrease in glucose-mediated insulin release and mitochondrial glucose metabolism.	Glucose	93-100	interleukin 1 alpha	Homo sapiens	53-57
2787754-0	1989	A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia.	Cyclophosphamide	106-122	interleukin 1 alpha	Homo sapiens	39-52
2666106-17	1989	It is conceivable that the IL-1-induced suppression and shift in islet metabolism can be an explanation for the beta-cell insensitivity to glucose observed in the early phases of human and experimental insulin-dependent diabetes mellitus.	Glucose	139-146	interleukin 1 alpha	Homo sapiens	27-31
2700206-7	1989	Moreover, purified IL1 induced PGE2 synthesis in resting Mo and increased its production when Mo were activated by LPS.	Dinoprostone	31-35	interleukin 1 alpha	Homo sapiens	19-22
2668162-1	1989	Recombinant human interleukin-1 alpha (rhIL-1 alpha) and recombinant human interleukin 1 beta (rhIL-1 beta) stimulated the time- and concentration-dependent release of glycosaminoglycan (GAG) from bovine nasal cartilage explants.	Glycosaminoglycans	168-185	interleukin 1 alpha	Homo sapiens	18-37
2668162-1	1989	Recombinant human interleukin-1 alpha (rhIL-1 alpha) and recombinant human interleukin 1 beta (rhIL-1 beta) stimulated the time- and concentration-dependent release of glycosaminoglycan (GAG) from bovine nasal cartilage explants.	Glycosaminoglycans	187-190	interleukin 1 alpha	Homo sapiens	18-37
2550484-0	1989	Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists.	Arachidonic Acid	46-62	interleukin 1 alpha	Homo sapiens	89-102
2550484-2	1989	Interleukin 1 also stimulated prostaglandin synthesis.	Prostaglandins	30-43	interleukin 1 alpha	Homo sapiens	0-13
2668949-3	1989	In these animal models, a single injection of a low dose of human recombinant IL-1 normalized glucose blood levels for several hours.	Glucose	94-101	interleukin 1 alpha	Homo sapiens	78-82
2553967-3	1989	Tiaprofenic acid, a nonsteroidal antiinflammatory drug belonging to the propionic acid class, reduced both the proteoglycan catabolism (26 micrograms/ml, 6.3 +/- 1.4%; 2.6 micrograms/ml, 7.1 +/- 1.4%) and metalloprotease activity (26 micrograms/ml, 1.1 +/- 0.3 units/mg wet weight; 2.6 micrograms/ml, 1.1 +/- 0.2 units/mg wet weight) induced by IL-1 (10.2 +/- 2.3%; 1.7 +/- 0.4 units/mg wet weight).	tiaprofenic acid	0-16	interleukin 1 alpha	Homo sapiens	345-349
2787453-10	1989	In contrast, no IL-1 beta message was detectable, not even after treatment of the cells with phorbol ester or cycloheximide, which resulted in approximately 5-fold enhancement of IL-1 alpha mRNA expression.	Phorbol Esters	93-106	interleukin 1 alpha	Homo sapiens	179-189
2787453-10	1989	In contrast, no IL-1 beta message was detectable, not even after treatment of the cells with phorbol ester or cycloheximide, which resulted in approximately 5-fold enhancement of IL-1 alpha mRNA expression.	Cycloheximide	110-123	interleukin 1 alpha	Homo sapiens	179-189
2472451-6	1989	The effect of FK506 on inducible genes in non-T and non-lymphoid human cells was studied in LPS-induced monocytes and PMA or IL-1 activated synovial fibroblasts.	Tacrolimus	14-19	interleukin 1 alpha	Homo sapiens	125-129
2503867-0	1989	Comparison of interleukin 1 release and interleukin 1 mRNA expression of human monocytes activated by bacterial lipopolysaccharide or synthetic lipid A.	Lipid A	144-151	interleukin 1 alpha	Homo sapiens	40-53
2503867-2	1989	Here we show that in human peripheral blood monocytes, synthetic E. coli lipid A is as effective as the whole LPS molecule in inducing the production of interleukin 1 (IL-1) bioactivity which remains associated to the cells (i.e. IL-1 alpha).	Lipid A	73-80	interleukin 1 alpha	Homo sapiens	153-166
2503867-2	1989	Here we show that in human peripheral blood monocytes, synthetic E. coli lipid A is as effective as the whole LPS molecule in inducing the production of interleukin 1 (IL-1) bioactivity which remains associated to the cells (i.e. IL-1 alpha).	Lipid A	73-80	interleukin 1 alpha	Homo sapiens	168-172
2503867-2	1989	Here we show that in human peripheral blood monocytes, synthetic E. coli lipid A is as effective as the whole LPS molecule in inducing the production of interleukin 1 (IL-1) bioactivity which remains associated to the cells (i.e. IL-1 alpha).	Lipid A	73-80	interleukin 1 alpha	Homo sapiens	230-240
2503867-4	1989	Northern blotting analysis demonstrated, however, that LPS and lipid A are equally effective in inducing the accumulation of IL-1 alpha and IL-1 beta mRNA.	Lipid A	63-70	interleukin 1 alpha	Homo sapiens	125-135
2474611-7	1989	In a comparison of SAF-1 and Freund"s adjuvant, SAF-1 was superior to Freund"s adjuvant in eliciting polyclonal and hybridoma antibodies which neutralized the biological activity of IL-1 alpha.	saf-1	48-53	interleukin 1 alpha	Homo sapiens	182-192
2507329-1	1989	The ability of interleukin-1 (IL-1 alpha), IL-1 beta, tumour necrosis factor alpha (TNF alpha) and bradykinin to cause prostaglandin E2 (PGE2) release from human synovial cells was examined.	Dinoprostone	119-135	interleukin 1 alpha	Homo sapiens	30-40
2507329-1	1989	The ability of interleukin-1 (IL-1 alpha), IL-1 beta, tumour necrosis factor alpha (TNF alpha) and bradykinin to cause prostaglandin E2 (PGE2) release from human synovial cells was examined.	Dinoprostone	137-141	interleukin 1 alpha	Homo sapiens	30-40
2507329-3	1989	When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated.	Dinoprostone	95-99	interleukin 1 alpha	Homo sapiens	36-46
2788477-4	1989	A possible implication of the inhibitory action of interleukin-1 on acetylcholine production in neuronal transmission disorders is discussed.	Acetylcholine	68-81	interleukin 1 alpha	Homo sapiens	51-64
2500974-5	1989	Thus, IFN-gamma opposes the stimulatory effect of IL-1 on caseinase production and decreases IL-1-stimulated cartilage degradation, as measured by glycosaminoglycan release.	Glycosaminoglycans	147-164	interleukin 1 alpha	Homo sapiens	50-54
2500974-5	1989	Thus, IFN-gamma opposes the stimulatory effect of IL-1 on caseinase production and decreases IL-1-stimulated cartilage degradation, as measured by glycosaminoglycan release.	Glycosaminoglycans	147-164	interleukin 1 alpha	Homo sapiens	93-97
2544398-0	1989	Inhibitory effects of interleukin-1 on luteinizing hormone-stimulated adenosine 3",5"-monophosphate accumulation by cultured porcine granulosa cells.	Cyclic AMP	70-99	interleukin 1 alpha	Homo sapiens	22-35
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	Ammonium Sulfate	113-130	interleukin 1 alpha	Homo sapiens	16-29
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	Ammonium Sulfate	113-130	interleukin 1 alpha	Homo sapiens	31-35
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	2-diethylaminoethanol	146-150	interleukin 1 alpha	Homo sapiens	16-29
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	2-diethylaminoethanol	146-150	interleukin 1 alpha	Homo sapiens	31-35
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	Cellulose	151-160	interleukin 1 alpha	Homo sapiens	16-29
2670348-1	1989	An inhibitor of interleukin-1 (IL-1) was purified to homogeneity from febrile human urine by using a sequence of ammonium sulphate fractionation, DEAE-cellulose chromatography and gel filtration on a column of ACA 54.	Cellulose	151-160	interleukin 1 alpha	Homo sapiens	31-35
2544398-1	1989	To elucidate the mechanisms of the inhibitory effect of interleukin-1 (IL-1) on LH-stimulated progesterone secretion by cultured porcine granulosa cells, we examined which steps of the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway were affected by IL-1.	Luteinizing Hormone	80-82	interleukin 1 alpha	Homo sapiens	56-69
2544398-1	1989	To elucidate the mechanisms of the inhibitory effect of interleukin-1 (IL-1) on LH-stimulated progesterone secretion by cultured porcine granulosa cells, we examined which steps of the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway were affected by IL-1.	Luteinizing Hormone	80-82	interleukin 1 alpha	Homo sapiens	71-75
2544398-2	1989	Pretreatment of the cells for 48 h with IL-1 reduced intra- and extracellular cAMP accumulation in response to LH by 73% and 83%, respectively.	Cyclic AMP	78-82	interleukin 1 alpha	Homo sapiens	40-44
2544398-2	1989	Pretreatment of the cells for 48 h with IL-1 reduced intra- and extracellular cAMP accumulation in response to LH by 73% and 83%, respectively.	Luteinizing Hormone	111-113	interleukin 1 alpha	Homo sapiens	40-44
2544398-5	1989	The lowest concentration of IL-1 used (0.5 pg/ml), in contrast, showed a tendency to stimulate LH-induced cAMP accumulation.	Luteinizing Hormone	95-97	interleukin 1 alpha	Homo sapiens	28-32
2544398-5	1989	The lowest concentration of IL-1 used (0.5 pg/ml), in contrast, showed a tendency to stimulate LH-induced cAMP accumulation.	Cyclic AMP	106-110	interleukin 1 alpha	Homo sapiens	28-32
2544398-7	1989	IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity.	Cyclic AMP	57-61	interleukin 1 alpha	Homo sapiens	0-4
2544398-7	1989	IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity.	Cyclic AMP	57-61	interleukin 1 alpha	Homo sapiens	157-161
2544398-7	1989	IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity.	Colforsin	103-112	interleukin 1 alpha	Homo sapiens	0-4
2544398-7	1989	IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity.	Colforsin	103-112	interleukin 1 alpha	Homo sapiens	157-161
2544398-9	1989	These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems.	Luteinizing Hormone	61-63	interleukin 1 alpha	Homo sapiens	53-57
2544398-9	1989	These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems.	Progesterone	75-87	interleukin 1 alpha	Homo sapiens	53-57
2544398-9	1989	These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems.	Cyclic AMP	177-181	interleukin 1 alpha	Homo sapiens	53-57
2544398-9	1989	These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems.	Progesterone	192-204	interleukin 1 alpha	Homo sapiens	53-57
2504764-0	1989	Combination therapy of cyclosporine with steroid inhibits gamma-interferon and interleukin-1 gene expression at the level of mRNA synthesis in vivo.	Cyclosporine	23-35	interleukin 1 alpha	Homo sapiens	79-92
2503436-7	1989	The anti-CD3-induced thymidine uptake by T cells in the presence of IL-1 and IL-6 was significantly inhibited by anti-Tac antibody, suggesting that the proliferation of T cells in this system is mostly mediated by a IL-2-dependent pathway.	Thymidine	21-30	interleukin 1 alpha	Homo sapiens	68-72
2786503-7	1989	IL-1-inducing activity was greatly reduced by chemical alteration of the teichoic acid.	Teichoic Acids	73-86	interleukin 1 alpha	Homo sapiens	0-4
2504764-0	1989	Combination therapy of cyclosporine with steroid inhibits gamma-interferon and interleukin-1 gene expression at the level of mRNA synthesis in vivo.	Steroids	41-48	interleukin 1 alpha	Homo sapiens	79-92
2788696-5	1989	Both IL-1 alpha and beta inhibited TSH-induced Tg release at concentrations ranging from 0.01 to 10 U/ml.	Thyrotropin	35-38	interleukin 1 alpha	Homo sapiens	5-15
2545778-3	1989	PDGF and IL-1 operated synergistically in vitro to stimulate synoviocyte proliferation in the presence of indomethacin.	Indomethacin	106-118	interleukin 1 alpha	Homo sapiens	9-13
2545778-5	1989	Moreover, exogenous PGE2, a PG known to be produced in response to IL-1, dramatically inhibited synoviocyte proliferation induced by PDGF.	Dinoprostone	20-24	interleukin 1 alpha	Homo sapiens	67-71
2545778-5	1989	Moreover, exogenous PGE2, a PG known to be produced in response to IL-1, dramatically inhibited synoviocyte proliferation induced by PDGF.	Prostaglandins	20-22	interleukin 1 alpha	Homo sapiens	67-71
2545778-6	1989	PDGF also acted synergistically to markedly increase production of PGE2 stimulated by IL-1.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	86-90
2788696-9	1989	Both IL-1 alpha and beta inhibited TSH-induced Tg mRNA in a dose-responsive manner.	Thyrotropin	35-38	interleukin 1 alpha	Homo sapiens	5-15
2788696-12	1989	Furthermore, IL-1 stimulated [3H]thymidine uptake into thyrocyte DNA.	Tritium	30-32	interleukin 1 alpha	Homo sapiens	13-17
2504764-4	1989	Macrophages (m phi) from CsA-Pred-treated recipients displayed 60.0% inhibition (5.1 +/- 0.7 U/ml; N = 20; P less than 0.01) of interleukin-1 (IL-1) production compared with normal individuals (13.0 +/- 2.9 U/ml; N = 21).	Cyclosporine	25-28	interleukin 1 alpha	Homo sapiens	128-141
2788696-12	1989	Furthermore, IL-1 stimulated [3H]thymidine uptake into thyrocyte DNA.	Thymidine	33-42	interleukin 1 alpha	Homo sapiens	13-17
2504764-4	1989	Macrophages (m phi) from CsA-Pred-treated recipients displayed 60.0% inhibition (5.1 +/- 0.7 U/ml; N = 20; P less than 0.01) of interleukin-1 (IL-1) production compared with normal individuals (13.0 +/- 2.9 U/ml; N = 21).	Cyclosporine	25-28	interleukin 1 alpha	Homo sapiens	143-147
2788696-13	1989	These results demonstrate that IL-1 directly inhibits TSH-induced Tg gene expression and provide further support for a functional role of IL-1 as a local modulator of thyroid hormone synthesis.	Thyrotropin	54-57	interleukin 1 alpha	Homo sapiens	31-35
2504764-7	1989	These studies demonstrated that combination therapy of CsA with steroid inhibits both gamma-IFN and IL-1 gene expression at the level of mRNA at physiological concentrations.	Cyclosporine	55-58	interleukin 1 alpha	Homo sapiens	100-104
2788696-13	1989	These results demonstrate that IL-1 directly inhibits TSH-induced Tg gene expression and provide further support for a functional role of IL-1 as a local modulator of thyroid hormone synthesis.	Thyrotropin	54-57	interleukin 1 alpha	Homo sapiens	138-142
2504764-7	1989	These studies demonstrated that combination therapy of CsA with steroid inhibits both gamma-IFN and IL-1 gene expression at the level of mRNA at physiological concentrations.	Steroids	64-71	interleukin 1 alpha	Homo sapiens	100-104
2786594-0	1989	Interleukin 1 stimulates production of LTC4 and other eicosanoids by macrophages.	Eicosanoids	54-65	interleukin 1 alpha	Homo sapiens	0-13
2527495-7	1989	The turnover of the Raji IL-1 receptor, measured by inhibiting protein synthesis with cycloheximide, was much faster than that of the EL4 IL-1 receptor, with a half-time of 2 h as against 5 h. Treatment of 125I-IL-1-labelled IL-1 receptors in Raji and EL4 cells with neuraminidase decreased their molecular mass by approx.	Cycloheximide	86-99	interleukin 1 alpha	Homo sapiens	25-29
2527495-9	1989	The covalently labelled IL-1 receptors in both cell types were sensitive to treatment with endoglycosidase F, which decreased their molecular mass on SDS/PAGE by 12-13 kDa.	Sodium Dodecyl Sulfate	150-153	interleukin 1 alpha	Homo sapiens	24-28
2508446-1	1989	Following exposure of cultured human synovial cells to human recombinant interleukin 1 alpha (IL-1 alpha), we demonstrate the appearance of factors in the supernatant which stimulate human polymorphonuclear leukocyte (PMN) locomotion and elevate intracellular free calcium ([Ca++]i).	Calcium	265-272	interleukin 1 alpha	Homo sapiens	73-92
2542409-4	1989	The inhibition by PT was associated with a decrease in IL-1-mediated cAMP production.	Cyclic AMP	69-73	interleukin 1 alpha	Homo sapiens	55-59
2542409-5	1989	PT also inhibited IL-1-stimulated cAMP production in crude membrane fractions from 7OZ/3, YT, and 3T3 fibroblasts.	Cyclic AMP	34-38	interleukin 1 alpha	Homo sapiens	18-22
2542409-8	1989	PT induced the ADP-ribosylation of a 46-kDa substrate in membrane preparations from IL-1-responsive cells.	Adenosine Diphosphate	15-18	interleukin 1 alpha	Homo sapiens	84-88
2543455-4	1989	The IL-1 was semi-purified by (NH4)2SO4 precipitation, Superose prep 12 gel filtration, and anion-exchange chromatography strongly stimulated in vitro bone resorption.	Ammonium Sulfate	30-39	interleukin 1 alpha	Homo sapiens	4-8
2543455-4	1989	The IL-1 was semi-purified by (NH4)2SO4 precipitation, Superose prep 12 gel filtration, and anion-exchange chromatography strongly stimulated in vitro bone resorption.	superose	55-63	interleukin 1 alpha	Homo sapiens	4-8
2543455-5	1989	The stimulatory effect of the purified IL-1 on bone resorption was prostaglandin independent.	Prostaglandins	67-80	interleukin 1 alpha	Homo sapiens	39-43
2477997-0	1989	Effects of prostaglandins and cAMP levels on monocyte IL-1 production.	Prostaglandins	11-25	interleukin 1 alpha	Homo sapiens	54-58
2477997-1	1989	The effects of prostaglandin E2 (PGE2), as well as other cAMP-elevating agents, on the in vitro production of interleukin-1 (IL-1) by human monocytes (HM) were examined.	Dinoprostone	15-31	interleukin 1 alpha	Homo sapiens	110-123
2477997-1	1989	The effects of prostaglandin E2 (PGE2), as well as other cAMP-elevating agents, on the in vitro production of interleukin-1 (IL-1) by human monocytes (HM) were examined.	Dinoprostone	15-31	interleukin 1 alpha	Homo sapiens	125-129
2477997-1	1989	The effects of prostaglandin E2 (PGE2), as well as other cAMP-elevating agents, on the in vitro production of interleukin-1 (IL-1) by human monocytes (HM) were examined.	Dinoprostone	33-37	interleukin 1 alpha	Homo sapiens	110-123
2477997-1	1989	The effects of prostaglandin E2 (PGE2), as well as other cAMP-elevating agents, on the in vitro production of interleukin-1 (IL-1) by human monocytes (HM) were examined.	Dinoprostone	33-37	interleukin 1 alpha	Homo sapiens	125-129
2508446-1	1989	Following exposure of cultured human synovial cells to human recombinant interleukin 1 alpha (IL-1 alpha), we demonstrate the appearance of factors in the supernatant which stimulate human polymorphonuclear leukocyte (PMN) locomotion and elevate intracellular free calcium ([Ca++]i).	Calcium	265-272	interleukin 1 alpha	Homo sapiens	94-104
2552771-0	1989	Chondrocyte activation by interleukin-1: synergism with fibroblast growth factor and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	85-110	interleukin 1 alpha	Homo sapiens	26-39
2477997-2	1989	Exposure to E. coli lipopolysacharide (LPS) resulted in a dose- and time-dependent increase of IL-1 activity in monocytes culture supernatants.	lipopolysacharide	20-37	interleukin 1 alpha	Homo sapiens	95-99
2477997-2	1989	Exposure to E. coli lipopolysacharide (LPS) resulted in a dose- and time-dependent increase of IL-1 activity in monocytes culture supernatants.	lps	39-42	interleukin 1 alpha	Homo sapiens	95-99
2477997-3	1989	Maximal levels of secreted IL-1 in response to 10 ng LPS/ml were obtained at 18 h. PGE1, PGE2, cholera toxin (CT) and the phosphodiesterase inhibitor, isobutylmethylxanthin (IBMX), when added with LPS, resulted in a dose-dependent increase in cellular cAMP and in secreted IL-1.	lps	53-56	interleukin 1 alpha	Homo sapiens	27-31
2477997-3	1989	Maximal levels of secreted IL-1 in response to 10 ng LPS/ml were obtained at 18 h. PGE1, PGE2, cholera toxin (CT) and the phosphodiesterase inhibitor, isobutylmethylxanthin (IBMX), when added with LPS, resulted in a dose-dependent increase in cellular cAMP and in secreted IL-1.	1-Methyl-3-isobutylxanthine	174-178	interleukin 1 alpha	Homo sapiens	27-31
2477997-3	1989	Maximal levels of secreted IL-1 in response to 10 ng LPS/ml were obtained at 18 h. PGE1, PGE2, cholera toxin (CT) and the phosphodiesterase inhibitor, isobutylmethylxanthin (IBMX), when added with LPS, resulted in a dose-dependent increase in cellular cAMP and in secreted IL-1.	lps	197-200	interleukin 1 alpha	Homo sapiens	27-31
2552771-1	1989	Exposure to synovial factors or purified interleukin-1 (IL-1) induces the production of prostaglandin E2 (PGE2) and the neutral proteinases (NP) collagenase, gelatinase and stromelysin by lapine articular chondrocytes.	Dinoprostone	88-104	interleukin 1 alpha	Homo sapiens	41-54
2477997-4	1989	Maximal levels of secreted IL-1 were 2.5-5.0-fold over LPS alone.	lps	55-58	interleukin 1 alpha	Homo sapiens	27-31
2552771-1	1989	Exposure to synovial factors or purified interleukin-1 (IL-1) induces the production of prostaglandin E2 (PGE2) and the neutral proteinases (NP) collagenase, gelatinase and stromelysin by lapine articular chondrocytes.	Dinoprostone	88-104	interleukin 1 alpha	Homo sapiens	56-60
2477997-7	1989	Maximum cAMP levels was achieved at 10 min in response to either PGE1 or PGE2 and returned to near basal levels after 18 h. While PGE1 elevated cAMP to a larger extent than PGE2 (58- vs. 30-fold) the latter resulted in a higher levels of secreted IL-1.	Alprostadil	130-134	interleukin 1 alpha	Homo sapiens	247-251
2477997-7	1989	Maximum cAMP levels was achieved at 10 min in response to either PGE1 or PGE2 and returned to near basal levels after 18 h. While PGE1 elevated cAMP to a larger extent than PGE2 (58- vs. 30-fold) the latter resulted in a higher levels of secreted IL-1.	Dinoprostone	173-177	interleukin 1 alpha	Homo sapiens	247-251
2552771-1	1989	Exposure to synovial factors or purified interleukin-1 (IL-1) induces the production of prostaglandin E2 (PGE2) and the neutral proteinases (NP) collagenase, gelatinase and stromelysin by lapine articular chondrocytes.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	41-54
2552771-1	1989	Exposure to synovial factors or purified interleukin-1 (IL-1) induces the production of prostaglandin E2 (PGE2) and the neutral proteinases (NP) collagenase, gelatinase and stromelysin by lapine articular chondrocytes.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	56-60
2552772-0	1989	Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	116-129
2678951-3	1989	Several antirheumatic drugs were tested in a similar tissue culture system as potential inhibitors of the interleukin-1 alpha mediated stimulation of proteinase and PGE2 syntheses.	Dinoprostone	165-169	interleukin 1 alpha	Homo sapiens	106-125
2801306-5	1989	IL-1 also resulted in a dose-related decrease in the ability of cartilage to synthesize new proteoglycan as measured by 35S incorporation.	Sulfur-35	120-123	interleukin 1 alpha	Homo sapiens	0-4
2678952-2	1989	SK&amp;F 86002, a dual inhibitor of the arachidonate metabolism, has been shown to inhibit LPS induced IL-1 production in human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	103-107
2678952-2	1989	SK&amp;F 86002, a dual inhibitor of the arachidonate metabolism, has been shown to inhibit LPS induced IL-1 production in human monocytes.	Arachidonic Acid	40-52	interleukin 1 alpha	Homo sapiens	103-107
2678952-6	1989	Taken together these data indicate that the inhibitory effect of SK&amp;F 86002 on IL-1 production is selective and the production of cytokines in drug treated monocytes can be differentially affected.	amicloral	65-71	interleukin 1 alpha	Homo sapiens	83-87
2678953-2	1989	Addition of human r-IL-1 to human synovial cells in culture stimulated phospholipase A2 (PLA2) activity, inositol triphosphate production and plasminogen activator (PA) activity in a dose dependent manner with similar EC50 values (0.1-0.5 nM).	Inositol triphosphate	105-126	interleukin 1 alpha	Homo sapiens	20-24
2801311-6	1989	Thus, SK&amp;F 86002 may serve as a useful reagent in the understanding of the synthetic, processing and/or secretory pathways of interleukin-1, and may provide important insight into the treatment of disease states where aberrant IL-1 production is implicated.	amicloral	6-12	interleukin 1 alpha	Homo sapiens	231-235
2801317-0	1989	Inhibitory effects of E-5110 on interleukin-1 generation from human monocytes.	E 5110	22-28	interleukin 1 alpha	Homo sapiens	32-45
2801311-0	1989	Inhibitory effect of SK&amp;F 86002 on monocyte IL-1 production.	amicloral	21-27	interleukin 1 alpha	Homo sapiens	48-52
2801317-1	1989	Effects of E-5110, a novel non-steroidal antiinflammatory drug, on interleukin-1 (IL-1) generation from human monocytes were studied in vitro.	E 5110	11-17	interleukin 1 alpha	Homo sapiens	67-80
2801311-2	1989	SK&amp;F 86002-A2 was shown to be a potent inhibitor of IL-1 production with a 50% inhibitory concentration (IC50) of 1.3 +/- 0.5 microM.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	56-60
2801336-4	1989	Sphingosine and staurosporin, inhibitors of PKC, each eliminated the synergistic effect of PMA upon enzyme induction by high doses (10 U/ml) of IL-1, but failed to influence enzyme induction by this dose of IL-1 alone.	Staurosporine	16-28	interleukin 1 alpha	Homo sapiens	144-148
2801336-6	1989	Although these inhibitors reduced the synthesis of PGE2 in response to PMA, synthesis of PGE2 in response to both doses of IL-1 was greatly enhanced by the inhibitors.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	123-127
2787718-6	1989	These results suggest that the impaired IL-1 production of LN PBM is probably attributable, at least in part, to increased prostaglandin production and possibly influences the immune status of LN patients.	Prostaglandins	123-136	interleukin 1 alpha	Homo sapiens	40-44
2801317-1	1989	Effects of E-5110, a novel non-steroidal antiinflammatory drug, on interleukin-1 (IL-1) generation from human monocytes were studied in vitro.	E 5110	11-17	interleukin 1 alpha	Homo sapiens	82-86
2801317-3	1989	E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles.	E 5110	0-6	interleukin 1 alpha	Homo sapiens	26-30
2801317-3	1989	E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles.	Zymosan	91-98	interleukin 1 alpha	Homo sapiens	26-30
2801317-3	1989	E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles.	Silicon Dioxide	103-109	interleukin 1 alpha	Homo sapiens	26-30
2801317-4	1989	It was suggested that the inhibition of IL-1 generation by E-5110 was independent of the inhibitory effects on arachidonate cyclooxygenase and/or lipoxygenase because indomethacin, piroxicam, BW755C and AA861 had no effects on IL-1 generation.	E 5110	59-65	interleukin 1 alpha	Homo sapiens	40-44
2801317-5	1989	Hydrocortisone (IC50:0.084 microM), aurothioglucose (11.5 microM) and lobenzarit (75.0 microM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 microM).	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	163-167
2801317-5	1989	Hydrocortisone (IC50:0.084 microM), aurothioglucose (11.5 microM) and lobenzarit (75.0 microM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 microM).	Aurothioglucose	36-51	interleukin 1 alpha	Homo sapiens	163-167
2801317-5	1989	Hydrocortisone (IC50:0.084 microM), aurothioglucose (11.5 microM) and lobenzarit (75.0 microM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 microM).	lobenzarit	70-80	interleukin 1 alpha	Homo sapiens	163-167
2801317-5	1989	Hydrocortisone (IC50:0.084 microM), aurothioglucose (11.5 microM) and lobenzarit (75.0 microM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 microM).	E 5110	185-191	interleukin 1 alpha	Homo sapiens	163-167
2801336-4	1989	Sphingosine and staurosporin, inhibitors of PKC, each eliminated the synergistic effect of PMA upon enzyme induction by high doses (10 U/ml) of IL-1, but failed to influence enzyme induction by this dose of IL-1 alone.	Sphingosine	0-11	interleukin 1 alpha	Homo sapiens	144-148
2788408-5	1989	The increased production of prostaglandin E2, which is initiated when IL1 or TNF bind to the chondrocytes, was the same in the presence or absence of IGF 1.	Dinoprostone	28-44	interleukin 1 alpha	Homo sapiens	70-73
2477329-8	1989	The detection of IL 1 activity by crystal violet staining of human dermal fibroblasts was easier and faster than by measurement of thymidine incorporation of fibroblasts or mouse thymocytes; without loss of sensitivity, the sample capacity of the IL 1 assay could be enhanced, and the use of experimental animals was avoided.	Gentian Violet	34-48	interleukin 1 alpha	Homo sapiens	17-21
2656872-2	1989	Interleukin 1 alpha and beta immunoreactive species were detected by Western blot analysis only when epidermal extracts were obtained in extraction buffers containing dithiothreitol (DTT), sodium dodecyl sulfate (SDS), or 2 mercaptoethanol.	Dithiothreitol	167-181	interleukin 1 alpha	Homo sapiens	0-19
2786877-4	1989	The protein adsorbed polymers were evaluated for their potential to activate the monocyte/macrophage cellular population in vitro as assessed by the induction of the monocyte/macrophage inflammatory mediator, Interleukin 1 (IL1).	Polymers	21-29	interleukin 1 alpha	Homo sapiens	209-222
2786877-4	1989	The protein adsorbed polymers were evaluated for their potential to activate the monocyte/macrophage cellular population in vitro as assessed by the induction of the monocyte/macrophage inflammatory mediator, Interleukin 1 (IL1).	Polymers	21-29	interleukin 1 alpha	Homo sapiens	224-227
2786877-5	1989	Suppression of IL1 was observed when protein adsorbed polymers were compared to the appropriate protein adsorbed control.	Polymers	54-62	interleukin 1 alpha	Homo sapiens	15-18
2786877-6	1989	Protein adsorbed polymers, when compared to polymers without protein adsorption, stimulated IL1 production.	Polymers	17-25	interleukin 1 alpha	Homo sapiens	92-95
2786877-6	1989	Protein adsorbed polymers, when compared to polymers without protein adsorption, stimulated IL1 production.	Polymers	44-52	interleukin 1 alpha	Homo sapiens	92-95
2497185-6	1989	Enhanced thrombin-stimulated PGI2 production was also observed in HUVEC pretreated with the related cytokines IL-1 alpha, TNF, or lymphotoxin.	Epoprostenol	29-33	interleukin 1 alpha	Homo sapiens	110-120
2656872-2	1989	Interleukin 1 alpha and beta immunoreactive species were detected by Western blot analysis only when epidermal extracts were obtained in extraction buffers containing dithiothreitol (DTT), sodium dodecyl sulfate (SDS), or 2 mercaptoethanol.	Dithiothreitol	183-186	interleukin 1 alpha	Homo sapiens	0-19
2656872-2	1989	Interleukin 1 alpha and beta immunoreactive species were detected by Western blot analysis only when epidermal extracts were obtained in extraction buffers containing dithiothreitol (DTT), sodium dodecyl sulfate (SDS), or 2 mercaptoethanol.	Sodium Dodecyl Sulfate	189-211	interleukin 1 alpha	Homo sapiens	0-19
2656872-2	1989	Interleukin 1 alpha and beta immunoreactive species were detected by Western blot analysis only when epidermal extracts were obtained in extraction buffers containing dithiothreitol (DTT), sodium dodecyl sulfate (SDS), or 2 mercaptoethanol.	Sodium Dodecyl Sulfate	213-216	interleukin 1 alpha	Homo sapiens	0-19
2656872-2	1989	Interleukin 1 alpha and beta immunoreactive species were detected by Western blot analysis only when epidermal extracts were obtained in extraction buffers containing dithiothreitol (DTT), sodium dodecyl sulfate (SDS), or 2 mercaptoethanol.	Mercaptoethanol	224-239	interleukin 1 alpha	Homo sapiens	0-19
2549432-3	1989	Cloricromene (5-50 microM) induced dose-related inhibition of PMN adhesion to untreated and IL-1 treated EC.	cloricromen	0-12	interleukin 1 alpha	Homo sapiens	92-96
2539970-7	1989	These findings suggest that PTH-rP and IL-1 alpha produced by the tumor cells were synergistically responsible for the humoral hypercalcemia observed in both the original patient and the tumor-bearing nude mice, and that at least two bone-resorbing factors [PTH-rP and another nonadenylate cyclase-stimulating bone-resorbing factor(s)] are active in patients with malignancy-associated hypercalcemia, in whom nephrogenous cAMP excretion is neither increased nor decreased.	Cyclic AMP	422-426	interleukin 1 alpha	Homo sapiens	39-49
2664844-6	1989	Fever is the result when IL-1 initiates the synthesis of prostaglandins, notably prostaglandin E2 in the thermoregulatory center located in the anterior hypothalamus.	Prostaglandins	57-71	interleukin 1 alpha	Homo sapiens	25-29
2664844-6	1989	Fever is the result when IL-1 initiates the synthesis of prostaglandins, notably prostaglandin E2 in the thermoregulatory center located in the anterior hypothalamus.	Dinoprostone	81-97	interleukin 1 alpha	Homo sapiens	25-29
2786341-4	1989	Because interleukin-1 is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammatory mediator, we propose that interleukin-1 may act as a signal for the onset of human labor in the setting of intrauterine infection.	Prostaglandins	48-61	interleukin 1 alpha	Homo sapiens	8-21
2786341-4	1989	Because interleukin-1 is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammatory mediator, we propose that interleukin-1 may act as a signal for the onset of human labor in the setting of intrauterine infection.	Prostaglandins	48-61	interleukin 1 alpha	Homo sapiens	146-159
2786341-12	1989	A strong correlation between interleukin-1 and amniotic fluid concentrations of prostaglandin E2 and prostaglandin F2 alpha was found in women in preterm labor.	Dinoprostone	80-96	interleukin 1 alpha	Homo sapiens	29-42
2786341-12	1989	A strong correlation between interleukin-1 and amniotic fluid concentrations of prostaglandin E2 and prostaglandin F2 alpha was found in women in preterm labor.	Dinoprost	101-117	interleukin 1 alpha	Homo sapiens	29-42
2565739-3	1989	Monocytes deficient in IL-1 production could be restored to normal production after incubation with indomethacin in three of five deficient patients.	Indomethacin	100-112	interleukin 1 alpha	Homo sapiens	23-27
2738158-4	1989	Compared with the uninvolved skin fibroblasts, those from involved skin showed (a) a slower rate of proliferation, (b) a cyclical pattern of PGE2 synthesis, and (c) an approximately 20-fold greater synthesis of PGE2 in response to human purified IL-1, a cytokine known to be secreted by epidermal keratinocytes.	Dinoprostone	211-215	interleukin 1 alpha	Homo sapiens	246-250
2661416-4	1989	Recombinant interleukin-1 (IL-1) or recombinant IL-2 strongly enhanced PGE2 synthesis in LPS-stimulated Mo cultures, whereas recombinant interferon-gamma (IFN-gamma) partially inhibited its production.	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	12-31
2549403-0	1989	Interleukin-1 induction by lipopolysaccharides: structural requirements of the 3-deoxy-D-manno-2-octulosonic acid (KDO).	3-deoxy-manno-oct-2-ulopyranosonic acid	79-113	interleukin 1 alpha	Homo sapiens	0-13
2497108-7	1989	After the lattice contraction is complete, the basal arachidonate metabolism of matrix-embedded cells have the same capacity to synthesize PGE2 in response to IL-1 as do cells grown on plastic.	Arachidonic Acid	53-65	interleukin 1 alpha	Homo sapiens	159-163
2497108-7	1989	After the lattice contraction is complete, the basal arachidonate metabolism of matrix-embedded cells have the same capacity to synthesize PGE2 in response to IL-1 as do cells grown on plastic.	Dinoprostone	139-143	interleukin 1 alpha	Homo sapiens	159-163
2788763-2	1989	In patients dialyzed with new hollow-fiber cuprophane dialyzers, predialytic (T0) monocyte-associated IL-1 activity was 12.5 +/- 3.0 U/ml (mean +/- SEM), a value that was higher than that found in normal individuals (2.85 +/- 0.85 U/ml; P less than 0.0025) and in non-dialyzed patients with chronic renal failure (0.95 +/- 0.85 U/ml, P less than 0.0001).	cuprammonium cellulose	43-53	interleukin 1 alpha	Homo sapiens	102-106
2788763-3	1989	Cell-associated IL-1 activity was consistently increased after five hours of dialysis with cuprophane membranes (42.4 +/- 5.5 U/ml, P less than 0.0005).	cuprammonium cellulose	91-101	interleukin 1 alpha	Homo sapiens	16-20
2788763-7	1989	Monocytes obtained at the beginning and five hours of dialysis from patients dialyzed with polyacrylonitrile devices, and monocytes obtained at five hours but not at the beginning of dialysis from patients dialyzed with cuprophane membranes, spontaneously released extracellular IL-1 after 24 hours of culture in serum free conditions.	polyacrylonitrile	91-108	interleukin 1 alpha	Homo sapiens	279-283
2549403-0	1989	Interleukin-1 induction by lipopolysaccharides: structural requirements of the 3-deoxy-D-manno-2-octulosonic acid (KDO).	2-keto-3-deoxyoctonate	115-118	interleukin 1 alpha	Homo sapiens	0-13
2549403-1	1989	We previously showed the importance of the 3-deoxy-D-manno-2-octulosonic acid (KDO) residue in endotoxins (lipopolysaccharides, LPS) for the induction of the synthesis and release of interleukin-1 (IL-1) by human monocytes.	3-deoxy-manno-oct-2-ulopyranosonic acid	43-77	interleukin 1 alpha	Homo sapiens	183-196
2549403-1	1989	We previously showed the importance of the 3-deoxy-D-manno-2-octulosonic acid (KDO) residue in endotoxins (lipopolysaccharides, LPS) for the induction of the synthesis and release of interleukin-1 (IL-1) by human monocytes.	3-deoxy-manno-oct-2-ulopyranosonic acid	43-77	interleukin 1 alpha	Homo sapiens	198-202
2549403-1	1989	We previously showed the importance of the 3-deoxy-D-manno-2-octulosonic acid (KDO) residue in endotoxins (lipopolysaccharides, LPS) for the induction of the synthesis and release of interleukin-1 (IL-1) by human monocytes.	2-keto-3-deoxyoctonate	79-82	interleukin 1 alpha	Homo sapiens	183-196
2549403-1	1989	We previously showed the importance of the 3-deoxy-D-manno-2-octulosonic acid (KDO) residue in endotoxins (lipopolysaccharides, LPS) for the induction of the synthesis and release of interleukin-1 (IL-1) by human monocytes.	2-keto-3-deoxyoctonate	79-82	interleukin 1 alpha	Homo sapiens	198-202
2564859-4	1989	Adult CD4-, CD8- thymocytes also exhibited greater calcium mobilization following anti-CD3 stimulation IL-2-dependent activation with anti-Thy-1 or IL-1 + IL-2 in the absence of PMA resulted in marked expansion of CD 3+, F23.1+, CD4-, CD8- thymocytes, a population absent in fetal thymocytes but constituting 4% of pre-cultured CD4-, CD8- adult thymocytes.	Calcium	51-58	interleukin 1 alpha	Homo sapiens	148-152
2662368-3	1989	In fact, prostaglandin E2 is involved in most of the mechanisms and its secretion is itself stimulated by IL1.	Dinoprostone	9-25	interleukin 1 alpha	Homo sapiens	106-109
2662368-6	1989	Thus, in vitro experiments have shown that naproxen reduces the PGE2-dependent inhibitory effect exerted by IL1 on the biosynthesis of collagen and proteoglycans and suggest that this NSAIA may be of use in degenerative osteoarticular disease.	Naproxen	43-51	interleukin 1 alpha	Homo sapiens	108-111
2662368-6	1989	Thus, in vitro experiments have shown that naproxen reduces the PGE2-dependent inhibitory effect exerted by IL1 on the biosynthesis of collagen and proteoglycans and suggest that this NSAIA may be of use in degenerative osteoarticular disease.	Dinoprostone	64-68	interleukin 1 alpha	Homo sapiens	108-111
2784382-7	1989	Four of nine subjects accounted for the observed impairment in virus inactivation; cells from these four subjects demonstrated an increase in interleukin-1 (IL-1) production after NO2 vs air, whereas the five remaining subjects decreased IL-1 production after NO2.	Nitrogen Dioxide	180-183	interleukin 1 alpha	Homo sapiens	142-161
2524223-5	1989	Dacron and polyethylene surfaces had a greater density of cells showing morphology indicative of activation, corresponding to elevated levels of IL1 in these cultures.	Polyethylene Terephthalates	0-6	interleukin 1 alpha	Homo sapiens	145-148
2524223-5	1989	Dacron and polyethylene surfaces had a greater density of cells showing morphology indicative of activation, corresponding to elevated levels of IL1 in these cultures.	Polyethylene	11-23	interleukin 1 alpha	Homo sapiens	145-148
2524223-6	1989	Biomer and polydimethylsiloxane surfaces showed fewer activated cells and had lower IL1 levels in culture.	baysilon	11-31	interleukin 1 alpha	Homo sapiens	84-87
2524223-7	1989	Expanded polytetrafluorethylene resulted in intermediate levels of IL1 and attached cells showing activated morphology.	polytetrafluorethylene	9-31	interleukin 1 alpha	Homo sapiens	67-70
2631873-0	1989	Modulation of macrophage iron metabolism by tumour necrosis factor and interleukin 1.	Iron	25-29	interleukin 1 alpha	Homo sapiens	71-84
2784382-7	1989	Four of nine subjects accounted for the observed impairment in virus inactivation; cells from these four subjects demonstrated an increase in interleukin-1 (IL-1) production after NO2 vs air, whereas the five remaining subjects decreased IL-1 production after NO2.	Nitrogen Dioxide	180-183	interleukin 1 alpha	Homo sapiens	157-161
2539420-7	1989	PAHA stimulated interleukin-1 production by adherent cells at 25 mumol/L but had no effect at lower concentrations.	procainamide 4-hydroxylamine	0-4	interleukin 1 alpha	Homo sapiens	16-29
2527507-3	1989	Monokines such as interleukin 1 (IL-1) are known to mediate tissue lesions by inducing collagenase and prostaglandin E2 (PGE2) production.	Dinoprostone	103-119	interleukin 1 alpha	Homo sapiens	33-37
2527507-3	1989	Monokines such as interleukin 1 (IL-1) are known to mediate tissue lesions by inducing collagenase and prostaglandin E2 (PGE2) production.	Dinoprostone	121-125	interleukin 1 alpha	Homo sapiens	33-37
2540210-0	1989	Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems.	Prostaglandins	25-38	interleukin 1 alpha	Homo sapiens	0-13
2540210-0	1989	Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems.	Cyclic AMP	53-63	interleukin 1 alpha	Homo sapiens	0-13
2540210-2	1989	One hour after its addition, IL-1 stimulated synthesis of prostaglandin E2 (PGE2), which continued to accumulate for 4 days.	Dinoprostone	58-74	interleukin 1 alpha	Homo sapiens	29-33
2540210-2	1989	One hour after its addition, IL-1 stimulated synthesis of prostaglandin E2 (PGE2), which continued to accumulate for 4 days.	Dinoprostone	76-80	interleukin 1 alpha	Homo sapiens	29-33
2540210-3	1989	IL-1 also stimulated cAMP accumulation.	Cyclic AMP	21-25	interleukin 1 alpha	Homo sapiens	0-4
2540210-4	1989	Indomethacin blocked cAMP accumulation in response to IL-1, suggesting that PGE2 was responsible for the increase.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	54-58
2540210-4	1989	Indomethacin blocked cAMP accumulation in response to IL-1, suggesting that PGE2 was responsible for the increase.	Cyclic AMP	21-25	interleukin 1 alpha	Homo sapiens	54-58
2540210-4	1989	Indomethacin blocked cAMP accumulation in response to IL-1, suggesting that PGE2 was responsible for the increase.	Dinoprostone	76-80	interleukin 1 alpha	Homo sapiens	54-58
2540210-6	1989	IL-1 enhanced thymidine incorporation, and indomethacin attenuated responses to lower concentrations.	Thymidine	14-23	interleukin 1 alpha	Homo sapiens	0-4
2540210-7	1989	Thus, PGE2 appeared to play a role in the ability of low concentrations of IL-1 to stimulate thymidine incorporation.	Dinoprostone	6-10	interleukin 1 alpha	Homo sapiens	75-79
2540210-7	1989	Thus, PGE2 appeared to play a role in the ability of low concentrations of IL-1 to stimulate thymidine incorporation.	Thymidine	93-102	interleukin 1 alpha	Homo sapiens	75-79
2540210-8	1989	PGE2 augmented thymidine incorporation by increasing cAMP accumulation because in the presence of indomethacin addition of exogenous cAMP enhanced thymidine incorporation in response to low concentrations of IL-1.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	208-212
2540210-8	1989	PGE2 augmented thymidine incorporation by increasing cAMP accumulation because in the presence of indomethacin addition of exogenous cAMP enhanced thymidine incorporation in response to low concentrations of IL-1.	Cyclic AMP	133-137	interleukin 1 alpha	Homo sapiens	208-212
2540210-8	1989	PGE2 augmented thymidine incorporation by increasing cAMP accumulation because in the presence of indomethacin addition of exogenous cAMP enhanced thymidine incorporation in response to low concentrations of IL-1.	Thymidine	147-156	interleukin 1 alpha	Homo sapiens	208-212
2540210-11	1989	In summary, IL-1 stimulates PGE2 synthesis.	Dinoprostone	28-32	interleukin 1 alpha	Homo sapiens	12-16
2540210-12	1989	PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	62-66
2559195-0	1989	Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1.	Prostaglandins E	24-39	interleukin 1 alpha	Homo sapiens	109-122
2540210-12	1989	PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation.	Cyclic AMP	26-30	interleukin 1 alpha	Homo sapiens	62-66
2540210-12	1989	PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation.	Dinoprostone	78-82	interleukin 1 alpha	Homo sapiens	62-66
2540210-12	1989	PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation.	Thymidine	97-106	interleukin 1 alpha	Homo sapiens	62-66
2559195-8	1989	injection of IL-1 alpha (15 micrograms/kg) were completely abolished, and conversely hypothermia occurred, when the animals were pre-treated with a cyclo-oxygenase inhibitor, indomethacin (INDO).	Indomethacin	175-187	interleukin 1 alpha	Homo sapiens	13-23
2559195-8	1989	injection of IL-1 alpha (15 micrograms/kg) were completely abolished, and conversely hypothermia occurred, when the animals were pre-treated with a cyclo-oxygenase inhibitor, indomethacin (INDO).	Indomethacin	189-193	interleukin 1 alpha	Homo sapiens	13-23
2559195-11	1989	injection of IL-1 alpha is processed through the action of prostaglandins.	Prostaglandins	59-73	interleukin 1 alpha	Homo sapiens	13-23
2522659-0	1989	Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.	Steroids	8-15	interleukin 1 alpha	Homo sapiens	77-90
2522659-2	1989	Since an acceleration of bone loss following menopause contributes to the risk of osteoporosis in women, we have studied the effects of menopause and ovarian steroid treatment on IL-1 release by monocytes obtained from nonosteoporotic and osteoporotic women.	Steroids	158-165	interleukin 1 alpha	Homo sapiens	179-183
2522659-3	1989	IL-1 activity in the monocyte culture medium derived from untreated postmenopausal women (nonosteoporotic and osteoporotic) was higher than in the medium derived from either untreated premenopausal or estrogen/progesterone-treated postmenopausal women.	Progesterone	210-222	interleukin 1 alpha	Homo sapiens	0-4
2522659-9	1989	Although a cause-effect relationship has not been established, it is our hypothesis, based on these data, that alterations in IL-1 production may underlie the postmenopausal acceleration in bone loss and its inhibition by ovarian steroids.	Steroids	230-238	interleukin 1 alpha	Homo sapiens	126-130
2785711-1	1989	A pool of human sera from healthy blood donors was found to interfere competitively with the binding of 125I-labelled human recombinant interleukin 1 alpha (rIL-1 alpha) to the murine T-cell line EL4.	Iodine-125	104-108	interleukin 1 alpha	Homo sapiens	136-155
2497512-3	1989	We report that the release of IL-1 is markedly enhanced in macrophages stimulated with polyglucose in either form in combination with native low-density lipoprotein (LDL) or acetyl LDL at a concentration of 100 micrograms/ml.	Glucans	87-98	interleukin 1 alpha	Homo sapiens	30-34
2649105-5	1989	Immunoaffinity chromatography followed by Western blotting shows that IL-6 species secreted by IL-1 alpha-induced HUVEC are of molecular mass 23-25, 27-30 and 45 kDa as judged by SDS-PAGE under reducing conditions.	Sodium Dodecyl Sulfate	179-182	interleukin 1 alpha	Homo sapiens	95-105
2784143-0	1989	Protective effects of IL-1 on human hematopoietic progenitor cells treated in vitro with 4-hydroperoxycyclophosphamide.	perfosfamide	89-118	interleukin 1 alpha	Homo sapiens	22-26
2539976-0	1989	Interleukin-1 alpha exerts glucose-dependent stimulatory and inhibitory effects on islet cell phosphoinositide hydrolysis and insulin secretion.	Glucose	27-34	interleukin 1 alpha	Homo sapiens	0-19
2539976-0	1989	Interleukin-1 alpha exerts glucose-dependent stimulatory and inhibitory effects on islet cell phosphoinositide hydrolysis and insulin secretion.	Phosphatidylinositols	94-110	interleukin 1 alpha	Homo sapiens	0-19
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	[3h]inositol	34-46	interleukin 1 alpha	Homo sapiens	117-121
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Tritium	35-37	interleukin 1 alpha	Homo sapiens	117-121
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Inositol	38-46	interleukin 1 alpha	Homo sapiens	117-121
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Tritium	149-151	interleukin 1 alpha	Homo sapiens	117-121
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Inositol Phosphates	177-195	interleukin 1 alpha	Homo sapiens	117-121
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Glucose	264-271	interleukin 1 alpha	Homo sapiens	117-121
2539976-6	1989	2) Mannoheptulose, a competitive inhibitor of islet glucokinase, blocked the stimulatory effects of IL-1 noted in the presence of 7 mM glucose.	Mannoheptulose	3-17	interleukin 1 alpha	Homo sapiens	100-104
2539976-6	1989	2) Mannoheptulose, a competitive inhibitor of islet glucokinase, blocked the stimulatory effects of IL-1 noted in the presence of 7 mM glucose.	Glucose	135-142	interleukin 1 alpha	Homo sapiens	100-104
2539976-12	1989	6) These inhibitory effects of IL-1 were abolished if mannoheptulose was included during the 2-h incubation with 7 mM glucose plus 5.0 nM <protein-id="3605">IL-1.	Mannoheptulose	54-68	interleukin 1 alpha	Homo sapiens	31-35
2539976-12	1989	6) These inhibitory effects of IL-1 were abolished if mannoheptulose was included during the 2-h incubation with 7 mM glucose plus 5.0 nM <protein-id="3605">IL-1.	Glucose	118-125	interleukin 1 alpha	Homo sapiens	31-35
2539976-13	1989	7</protein-id>) The diacylglycerol kinase inhibitor 1-monooleoylglycerol (100 microM) significantly restored insulin output after IL-1 exposure (with 7 mM glucose).	monoolein	52-72	interleukin 1 alpha	Homo sapiens	130-134
2539976-13	1989	7</protein-id>) The diacylglycerol kinase inhibitor 1-monooleoylglycerol (100 microM) significantly restored insulin output after IL-1 exposure (with 7 mM glucose).	Glucose	155-162	interleukin 1 alpha	Homo sapiens	130-134
2539976-14	1989	8) Similar to the results obtained with 7 mM glucose plus IL-1, incubation of islets with 8-10 mM glucose alone produced dose-dependent impairments of [3H]inositol efflux patterns and inositol phosphate accumulation.	Glucose	98-105	interleukin 1 alpha	Homo sapiens	58-62
2539976-16	1989	These results demonstrate that IL-1 has glucose-dependent stimulatory and inhibitory effects on beta-cell function.	Glucose	40-47	interleukin 1 alpha	Homo sapiens	31-35
2784384-0	1989	Characterization of the interleukin-1-induced tyrosine phosphorylation of a 41-kDa plasma membrane protein of the human tumor cell line K 562.	Tyrosine	46-54	interleukin 1 alpha	Homo sapiens	24-37
2784384-4	1989	A 41-kDa protein (pp41) was specifically phosphorylated on a tyrosine residue in the presence of interleukin 1 in a dose- and time-dependent manner.	Tyrosine	61-69	interleukin 1 alpha	Homo sapiens	97-110
2784143-2	1989	In this study, we have investigated whether IL-1 can provide protection for human bone marrow colony-forming cells treated with high doses of 4-hydroperoxycyclophosphamide (4-HC), a potent derivative of cyclophosphamide.	perfosfamide	142-171	interleukin 1 alpha	Homo sapiens	44-48
2784143-2	1989	In this study, we have investigated whether IL-1 can provide protection for human bone marrow colony-forming cells treated with high doses of 4-hydroperoxycyclophosphamide (4-HC), a potent derivative of cyclophosphamide.	perfosfamide	173-177	interleukin 1 alpha	Homo sapiens	44-48
2784143-2	1989	In this study, we have investigated whether IL-1 can provide protection for human bone marrow colony-forming cells treated with high doses of 4-hydroperoxycyclophosphamide (4-HC), a potent derivative of cyclophosphamide.	Cyclophosphamide	155-171	interleukin 1 alpha	Homo sapiens	44-48
2783896-8	1989	Thus, these experiments clearly demonstrate that the suppression of Con A-driven T cell proliferation by calcitriol is Mo mediated and works by a non-IL-1 mechanism.	Calcitriol	105-115	interleukin 1 alpha	Homo sapiens	150-154
2784067-0	1989	Interleukin-1 accelerates murine granulocyte recovery following treatment with cyclophosphamide.	Cyclophosphamide	79-95	interleukin 1 alpha	Homo sapiens	0-13
2785834-2	1989	Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2).	Dinoprostone	184-200	interleukin 1 alpha	Homo sapiens	89-108
2785834-2	1989	Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2).	Dinoprostone	202-206	interleukin 1 alpha	Homo sapiens	89-108
2784471-4	1989	PBM, upon stimulation by lipopolysaccharide (LPS), expressed approximately ten-fold more IL-1 beta mRNA than IL-1 alpha.	pbm	0-3	interleukin 1 alpha	Homo sapiens	109-119
2495247-0	1989	Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.	Dinoprostone	25-29	interleukin 1 alpha	Homo sapiens	47-51
2465167-0	1989	Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.	Poly C	27-35	interleukin 1 alpha	Homo sapiens	0-13
2651462-8	1989	The results indicate that increasing the amount of N-fatty acids in the diet decreases the ability of blood mononuclear cells to synthesize IL-1 in vitro.	n-fatty acids	51-64	interleukin 1 alpha	Homo sapiens	140-144
2541163-3	1989	We report here on prostaglandin E and its relationship to interleukin 1, tumor necrosis factor, and leukotriene B4 produced by macrophages from blood and cerebrospinal fluid of MS patients and controls in vitro.	Prostaglandins E	18-33	interleukin 1 alpha	Homo sapiens	58-71
2651462-9	1989	It is suggested that the ameliorative effects of N-3 fatty acid dietary supplements in patients with hypersensitive diseases may be, in part, the result of decreased IL-1 production.	Fatty Acids, Omega-3	49-63	interleukin 1 alpha	Homo sapiens	166-170
2493647-1	1989	We have recently shown that the synthesis of cyclooxygenase [also called prostaglandin (PG) synthase or PG endoperoxide synthase; 8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1] in human dermal fibroblasts is markedly stimulated by the cytokine interleukin 1 (IL-1).	Prostaglandins	73-86	interleukin 1 alpha	Homo sapiens	288-292
2786129-6	1989	Human recombinant IL-1 alpha (10(-7) to 10(-9) M) administered into the lumina of the vessels depressed pumping activity approximately 5-30% at transmural pressures between 2 and 16 cm H2O.	Water	185-188	interleukin 1 alpha	Homo sapiens	18-28
2493647-1	1989	We have recently shown that the synthesis of cyclooxygenase [also called prostaglandin (PG) synthase or PG endoperoxide synthase; 8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1] in human dermal fibroblasts is markedly stimulated by the cytokine interleukin 1 (IL-1).	Hydrogen	154-162	interleukin 1 alpha	Homo sapiens	288-292
2537757-0	1989	Human recombinant interleukin-1 alpha increases biosynthesis of collagenase and hyaluronic acid in cultured human chorionic cells.	Hyaluronic Acid	80-95	interleukin 1 alpha	Homo sapiens	18-37
2537757-1	1989	The influence of human recombinant interleukin-1 alpha (hrIL-1) on biosynthesis of collagenase and glycosaminoglycans was investigated with fibroblast-like cells of human chorionic membrane.	Glycosaminoglycans	99-117	interleukin 1 alpha	Homo sapiens	35-54
2643439-6	1989	Exposure of human umbilical vein endothelial cells to bradykinin, thrombin or interleukin-1 resulted in negligible release of either hexosaminidase or lactate dehydrogenase (LDH), in contrast to phorbol myristate acetate, which caused a parallel, dose-dependent release of both enzymes.	Tetradecanoylphorbol Acetate	195-220	interleukin 1 alpha	Homo sapiens	78-91
2647121-1	1989	Incubation of human recombinant IL-1 alpha (hrIL-1 alpha) with cultured human endothelial cells induced a dose- and time-dependent increase in the release of prostacyclin (PGI2).	Epoprostenol	158-170	interleukin 1 alpha	Homo sapiens	32-42
2493252-2	1989	In fibroblast cultures, recombinant human interleukin-1 alpha (rHuIL-1 alpha), rHuIL-1 beta, and recombinant human tumor necrosis factor alpha (rHuTNF alpha) stimulated hyaluronic acid (HA) production and, to a lesser extent, sulfated GAG production, while recombinant human gamma-interferon did not have a significant effect.	Hyaluronic Acid	169-184	interleukin 1 alpha	Homo sapiens	42-61
2537653-4	1989	The results indicate that interleukin 1 may play an important role in cyst expansion by its direct effects on fibroblast proliferation and bone resorption and by stimulating prostaglandin synthesis in stromal fibroblasts of the cyst capsule.	Prostaglandins	174-187	interleukin 1 alpha	Homo sapiens	26-39
2647121-1	1989	Incubation of human recombinant IL-1 alpha (hrIL-1 alpha) with cultured human endothelial cells induced a dose- and time-dependent increase in the release of prostacyclin (PGI2).	Epoprostenol	172-176	interleukin 1 alpha	Homo sapiens	32-42
2783391-9	1989	Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor.	Sulfur-35	177-180	interleukin 1 alpha	Homo sapiens	280-290
2783391-3	1989	In this report we describe a human astrocytoma cell line (T24) which produces IL-1 constitutively and upon induction with phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	122-147	interleukin 1 alpha	Homo sapiens	78-82
2783391-9	1989	Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor.	Sulfur-35	177-180	interleukin 1 alpha	Homo sapiens	111-115
2492458-0	1989	Synergy of interleukin 1 (IL-1) with arachidonic acid and A23187 in stimulating PGE synthesis in human fibroblasts: IL-1 stimulates fibroblast cyclooxygenase.	Prostaglandins E	80-83	interleukin 1 alpha	Homo sapiens	11-30
2783391-9	1989	Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor.	Sulfur-35	177-180	interleukin 1 alpha	Homo sapiens	242-252
2492458-0	1989	Synergy of interleukin 1 (IL-1) with arachidonic acid and A23187 in stimulating PGE synthesis in human fibroblasts: IL-1 stimulates fibroblast cyclooxygenase.	Prostaglandins E	80-83	interleukin 1 alpha	Homo sapiens	26-30
2492458-1	1989	The stimulation of prostaglandin E (PGE) synthesis by interleukin 1 (IL-1) has important physiologic effects in many target tissues.	Prostaglandins E	19-34	interleukin 1 alpha	Homo sapiens	54-73
2783675-0	1989	Modification of tissue-factor mRNA and protein response to thrombin and interleukin 1 by high glucose in cultured human endothelial cells.	Glucose	94-101	interleukin 1 alpha	Homo sapiens	72-85
2783675-6	1989	In contrast, the tissue-factor response to interleukin 1, a modulator of endothelial function in the context of host defense, was decreased in cells cultured in high glucose (P = .04).	Glucose	166-173	interleukin 1 alpha	Homo sapiens	43-56
2492458-1	1989	The stimulation of prostaglandin E (PGE) synthesis by interleukin 1 (IL-1) has important physiologic effects in many target tissues.	Prostaglandins E	36-39	interleukin 1 alpha	Homo sapiens	54-73
2783675-8	1989	The reciprocal effects of high glucose on the tissue-factor response to thrombin and interleukin 1 points to different pathways of tissue-factor stimulation by the two agents and suggests functional consequences pertinent to the increased thrombin activity and compromised host-defense mechanisms observed in diabetes.	Glucose	31-38	interleukin 1 alpha	Homo sapiens	85-98
2492458-2	1989	The mechanism(s) whereby IL-1 stimulates PGE synthesis is not well understood.	Prostaglandins E	41-44	interleukin 1 alpha	Homo sapiens	25-29
2492458-4	1989	We examined these mechanisms in IL-1 stimulation of human dermal fibroblast PGE synthesis.	Prostaglandins E	76-79	interleukin 1 alpha	Homo sapiens	32-36
2492458-7	1989	There was marked synergy between IL-1 and agents which increased availability of arachidonic acid.	Arachidonic Acid	81-97	interleukin 1 alpha	Homo sapiens	33-37
2492458-8	1989	For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid.	Calcimycin	41-47	interleukin 1 alpha	Homo sapiens	205-209
2492458-8	1989	For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid.	Prostaglandins E	109-112	interleukin 1 alpha	Homo sapiens	32-36
2492458-8	1989	For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid.	Prostaglandins E	134-137	interleukin 1 alpha	Homo sapiens	32-36
2495224-11	1989	Preincubation of cRCS-X cells with IL1 enhanced their ability to proliferate in response to BCGF or IL5 in [3H]thymidine incorporation assays, but the reverse sequence of cytokine addition showed no effect of IL1.	Tritium	108-110	interleukin 1 alpha	Homo sapiens	35-38
2492458-8	1989	For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid.	Arachidonic Acid	224-240	interleukin 1 alpha	Homo sapiens	32-36
2492458-11	1989	These results suggest that IL-1 increases fibroblast PGE synthesis by a mechanism(s) other than making available increased membrane arachidonic acid, and that at least part of its effect may be mediated by induction of cyclooxygenase.	Prostaglandins E	53-56	interleukin 1 alpha	Homo sapiens	27-31
2492458-11	1989	These results suggest that IL-1 increases fibroblast PGE synthesis by a mechanism(s) other than making available increased membrane arachidonic acid, and that at least part of its effect may be mediated by induction of cyclooxygenase.	Arachidonic Acid	132-148	interleukin 1 alpha	Homo sapiens	27-31
2492458-12	1989	Furthermore, the effect of IL-1 on fibroblast PGE synthesis is markedly potentiated by agents which increase available substrate.	Prostaglandins E	46-49	interleukin 1 alpha	Homo sapiens	27-31
2643630-7	1989	IL-1 acts selectively on endothelial cells as demonstrated by total inhibition of its effect by actinomycin D.	Dactinomycin	96-109	interleukin 1 alpha	Homo sapiens	0-4
2783571-1	1989	Interleukin-1 (IL-1) significantly inhibited basal progesterone secretion and influenced the cell number in high density cultures of porcine granulosa cells harvested from small (1-2 mm) or medium (3-5 mm) follicles.	Progesterone	51-63	interleukin 1 alpha	Homo sapiens	0-13
2783571-1	1989	Interleukin-1 (IL-1) significantly inhibited basal progesterone secretion and influenced the cell number in high density cultures of porcine granulosa cells harvested from small (1-2 mm) or medium (3-5 mm) follicles.	Progesterone	51-63	interleukin 1 alpha	Homo sapiens	15-19
2783571-2	1989	These two effects of IL-1 showed similar but inverse dose-response relationships: Significant effects were observed at concentrations higher than 50 pg/ml, and the maximal effective concentration was 5 ng/ml, which reduced progesterone secretion by 53.5 +/- 2.1%.	Progesterone	223-235	interleukin 1 alpha	Homo sapiens	21-25
2465548-8	1989	Although constitutive levels of IL-1 biological activity and protein are significant in these cultures, IL-1 levels increase when either PMA or retinoic acid alone are added to cultures.	Tetradecanoylphorbol Acetate	137-140	interleukin 1 alpha	Homo sapiens	104-108
2783590-0	1989	Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1.	Glycosaminoglycans	15-32	interleukin 1 alpha	Homo sapiens	83-96
2783590-1	1989	Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171.	Hyaluronic Acid	13-28	interleukin 1 alpha	Homo sapiens	66-79
2465548-8	1989	Although constitutive levels of IL-1 biological activity and protein are significant in these cultures, IL-1 levels increase when either PMA or retinoic acid alone are added to cultures.	Tretinoin	144-157	interleukin 1 alpha	Homo sapiens	104-108
2465548-9	1989	IL-1 does not increase when PMA and retinoic acid are added simultaneously to cultures; nor is it induced when extracellular Ca2+ concentrations are raised to 2 mM.	Tetradecanoylphorbol Acetate	28-31	interleukin 1 alpha	Homo sapiens	0-4
2465548-9	1989	IL-1 does not increase when PMA and retinoic acid are added simultaneously to cultures; nor is it induced when extracellular Ca2+ concentrations are raised to 2 mM.	Tretinoin	36-49	interleukin 1 alpha	Homo sapiens	0-4
2642948-0	1989	A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone.	polysulfone P 1700	131-142	interleukin 1 alpha	Homo sapiens	22-62
2521831-2	1989	Equilibrium binding analysis using both 125I-labeled IL-1 alpha and IL-1 beta showed that RAJI cells have a higher number of binding sites/cell for IL-1 beta (2400, Kd 2.2 nM) than for IL-1 alpha (316, Kd 0.13 nM).	Iodine-125	40-44	interleukin 1 alpha	Homo sapiens	53-63
2521831-4	1989	Dexamethasone (DXM) induced on RAJI cells a time-dependent increase in binding sites for both IL-1 beta and IL-1 alpha without affecting their binding affinities.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	108-118
2521831-4	1989	Dexamethasone (DXM) induced on RAJI cells a time-dependent increase in binding sites for both IL-1 beta and IL-1 alpha without affecting their binding affinities.	Dexamethasone	15-18	interleukin 1 alpha	Homo sapiens	108-118
2463072-0	1989	Membrane-associated interleukin 1 alpha as a mediator of tumor cell killing by human blood monocytes fixed with paraformaldehyde.	paraform	112-128	interleukin 1 alpha	Homo sapiens	20-39
2646146-0	1989	Dexamethasone regulation of the expression of cytokine mRNAs induced by interleukin-1 in the astrocytoma cell line U373MG.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	72-85
2540636-0	1989	Leukotrienes and macrophage activation: augmented cytotoxic activity and enhanced interleukin 1, tumor necrosis factor and hydrogen peroxide production.	Leukotrienes	0-12	interleukin 1 alpha	Homo sapiens	82-118
2521349-5	1989	Thioglycollate, proteose-peptone, or IL-1 elicited peritoneal exudate cells were found to bind 125I-IL-1 alpha in a specific and saturable manner.	Thioglycolates	0-14	interleukin 1 alpha	Homo sapiens	100-110
2785335-2	1989	IL 1 induced PMN leukocyte accumulation that was slow in onset, reaching a peak rate at 3-4 h and that was inhibitable by Actinomycin D and Cycloheximide.	Dactinomycin	122-135	interleukin 1 alpha	Homo sapiens	0-4
2516411-5	1989	IL-1 stimulation of enhanced COX synthesis was time and dose dependent; as little as 0.03 units/ml of IL-1 produced significant stimulation of [35S]-labeled COX synthesis.	Sulfur-35	144-147	interleukin 1 alpha	Homo sapiens	0-4
2516411-5	1989	IL-1 stimulation of enhanced COX synthesis was time and dose dependent; as little as 0.03 units/ml of IL-1 produced significant stimulation of [35S]-labeled COX synthesis.	Sulfur-35	144-147	interleukin 1 alpha	Homo sapiens	102-106
2516411-7	1989	IL-1 treatment of cells in serum-free media yielded parallel dose response curves for stimulation of PGE2 formation, cellular solubilized COX activity and synthesis of newly formed COX, suggesting that this IL-1 effect is mediated solely via induction of new COX protein synthesis.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	0-4
2516411-7	1989	IL-1 treatment of cells in serum-free media yielded parallel dose response curves for stimulation of PGE2 formation, cellular solubilized COX activity and synthesis of newly formed COX, suggesting that this IL-1 effect is mediated solely via induction of new COX protein synthesis.	Dinoprostone	101-105	interleukin 1 alpha	Homo sapiens	207-211
2516411-9	1989	Serum synergistically augments the IL-1 effect on PGE2 synthesis in intact cells but concurrently blunts IL-1 induction of COX synthesis, thus suggesting that a factor (or factors) in serum may stimulate PGE2 production by activating cellular phospholipase(s).	Dinoprostone	50-54	interleukin 1 alpha	Homo sapiens	35-39
2516411-9	1989	Serum synergistically augments the IL-1 effect on PGE2 synthesis in intact cells but concurrently blunts IL-1 induction of COX synthesis, thus suggesting that a factor (or factors) in serum may stimulate PGE2 production by activating cellular phospholipase(s).	Dinoprostone	204-208	interleukin 1 alpha	Homo sapiens	35-39
2785335-2	1989	IL 1 induced PMN leukocyte accumulation that was slow in onset, reaching a peak rate at 3-4 h and that was inhibitable by Actinomycin D and Cycloheximide.	Cycloheximide	140-153	interleukin 1 alpha	Homo sapiens	0-4
2534786-0	1989	Functional maturation of thymocytes: recruitment of helper cells in the humoral immune response to SRBC in vitro by recombinant interleukin 1 (Il-1).	srbc	99-103	interleukin 1 alpha	Homo sapiens	128-147
2495247-6	1989	The TNF alpha and IL-1 activities induced by LPS and by LPS with IFN-gamma were reduced by PGE2, and stimulated by indomethacin.	Dinoprostone	91-95	interleukin 1 alpha	Homo sapiens	18-22
2495247-6	1989	The TNF alpha and IL-1 activities induced by LPS and by LPS with IFN-gamma were reduced by PGE2, and stimulated by indomethacin.	Indomethacin	115-127	interleukin 1 alpha	Homo sapiens	18-22
2534786-1	1989	In this report we demonstrated that recombinant human interleukin 1 alpha (Il-1) can directly promote generation of helper cells in the humoral immune response to SRBC in vitro from their intrathymic precursors.	srbc	163-167	interleukin 1 alpha	Homo sapiens	54-73
2534786-1	1989	In this report we demonstrated that recombinant human interleukin 1 alpha (Il-1) can directly promote generation of helper cells in the humoral immune response to SRBC in vitro from their intrathymic precursors.	srbc	163-167	interleukin 1 alpha	Homo sapiens	75-79
2701643-0	1989	Role of interleukin-1 in 4-hydroperoxycyclophosphamide toxicity to bone marrow progenitor cells: a review.	perfosfamide	25-54	interleukin 1 alpha	Homo sapiens	8-21
2701648-3	1989	The human IL-1 alpha inhibited dose-dependently the growth of syngeneic murine tumors transplanted in mice and completely regressed the tumors in some cases, and its antitumor activity was significantly enhanced in combination with indomethacin.	Indomethacin	232-244	interleukin 1 alpha	Homo sapiens	10-20
2701650-4	1989	Recombinant human IL-1 was perfused through rabbit colons and we observed elevated levels of PGE2, TxB2 and 6-keto-PGF1 alpha, the stable metabolite of PGI2.	Dinoprostone	93-97	interleukin 1 alpha	Homo sapiens	18-22
2701650-4	1989	Recombinant human IL-1 was perfused through rabbit colons and we observed elevated levels of PGE2, TxB2 and 6-keto-PGF1 alpha, the stable metabolite of PGI2.	Thromboxane B2	99-103	interleukin 1 alpha	Homo sapiens	18-22
2701650-4	1989	Recombinant human IL-1 was perfused through rabbit colons and we observed elevated levels of PGE2, TxB2 and 6-keto-PGF1 alpha, the stable metabolite of PGI2.	6-keto-pgf1	108-119	interleukin 1 alpha	Homo sapiens	18-22
2701650-4	1989	Recombinant human IL-1 was perfused through rabbit colons and we observed elevated levels of PGE2, TxB2 and 6-keto-PGF1 alpha, the stable metabolite of PGI2.	Epoprostenol	152-156	interleukin 1 alpha	Homo sapiens	18-22
2701650-9	1989	However, unlike other models of IL-1-induced protection, in this model cyclooxygenase products were required since we prevented the IL-1-induced protection with a single dose of ibuprofen given at the same time as the IL-1.	Ibuprofen	178-187	interleukin 1 alpha	Homo sapiens	32-36
2701650-9	1989	However, unlike other models of IL-1-induced protection, in this model cyclooxygenase products were required since we prevented the IL-1-induced protection with a single dose of ibuprofen given at the same time as the IL-1.	Ibuprofen	178-187	interleukin 1 alpha	Homo sapiens	132-136
2701650-9	1989	However, unlike other models of IL-1-induced protection, in this model cyclooxygenase products were required since we prevented the IL-1-induced protection with a single dose of ibuprofen given at the same time as the IL-1.	Ibuprofen	178-187	interleukin 1 alpha	Homo sapiens	132-136
2701650-10	1989	This correlated with the reduction in IL-1-induced PGE2.	Dinoprostone	51-55	interleukin 1 alpha	Homo sapiens	38-42
2484638-0	1989	Induction of macrophage tumoricidal activity, major histocompatibility complex class II antigen (Iak) expression, and interleukin-1 production by swainsonine.	Swainsonine	146-157	interleukin 1 alpha	Homo sapiens	118-131
2513997-8	1989	IL-1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites, most consistently, prostaglandin E.	Arachidonic Acid	72-88	interleukin 1 alpha	Homo sapiens	0-4
2513997-8	1989	IL-1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites, most consistently, prostaglandin E.	Prostaglandins E	121-136	interleukin 1 alpha	Homo sapiens	0-4
2783241-6	1989	Up-regulation of the IL-2 receptor beta chain (Tac) and increased [3H]thymidine incorporation in cultures containing IL-1 and IL-2 support this view.	Tritium	67-69	interleukin 1 alpha	Homo sapiens	117-121
2493987-4	1989	FK-565 also acted synergistically with rIFN-gamma to stimulate monocytes to produce membrane-associated IL-1 activity, which induced C3H/HeJ thymocyte blastogenesis in response to phytohemagglutinin P. The tumoricidal and thymocyte-stimulating activities of the fixed monocytes were almost completely inhibited by a specific anti-(IL-1 alpha) antiserum, but not by a specific anti-(IL-1 beta) antiserum or monoclonal anti-TNF antibody.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	0-6	interleukin 1 alpha	Homo sapiens	331-341
2493987-5	1989	These results suggest that membrane-associated IL-1 alpha of human blood monocytes can be induced by two activation signals (rIFN-gamma then FK-565) at their suboptimal concentrations.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	141-147	interleukin 1 alpha	Homo sapiens	47-57
2783241-6	1989	Up-regulation of the IL-2 receptor beta chain (Tac) and increased [3H]thymidine incorporation in cultures containing IL-1 and IL-2 support this view.	Thymidine	70-79	interleukin 1 alpha	Homo sapiens	117-121
2539275-0	1989	Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine.	Alkaloids	68-76	interleukin 1 alpha	Homo sapiens	30-43
2484435-1	1989	This study demonstrates synergistic effects on Tac expression by interleukin 1 (IL-1) or tumor necrosis factor alpha (TNF alpha) in combination with the adenylate cyclase stimulator, forskolin (FK), as well as by IL-1 with TNF alpha in the human NK-like leukemic cell line YT.	Colforsin	183-192	interleukin 1 alpha	Homo sapiens	213-217
2484435-4	1989	Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK).	Cyclic AMP	41-45	interleukin 1 alpha	Homo sapiens	133-137
2484435-4	1989	Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK).	Prostaglandins E	55-70	interleukin 1 alpha	Homo sapiens	133-137
2484435-4	1989	Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK).	Prostaglandins E	72-75	interleukin 1 alpha	Homo sapiens	133-137
2484435-4	1989	Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK).	1-Methyl-3-isobutylxanthine	80-103	interleukin 1 alpha	Homo sapiens	133-137
2484435-4	1989	Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK).	1-Methyl-3-isobutylxanthine	105-109	interleukin 1 alpha	Homo sapiens	133-137
2539275-0	1989	Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine.	tetrandrine	77-88	interleukin 1 alpha	Homo sapiens	30-43
2539275-4	1989	Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.	tetrandrine	0-11	interleukin 1 alpha	Homo sapiens	84-88
2540117-2	1989	These novel acetohydroxamic acids were found to inhibit the proliferation of lymphocytes in response to Interleukin-1 (IL-1) and Interleukin-2 (IL-2).	acetohydroxamic acid	12-33	interleukin 1 alpha	Homo sapiens	104-124
2792493-2	1989	Because lobenzarit disodium, an immunomodulator, inhibits the production of IL-1 in peripheral and peritoneal macrophages, we studied the clinical effects of this compound on psoriatic lesions.	lobenzarit	8-27	interleukin 1 alpha	Homo sapiens	76-80
2674374-0	1989	Expression of IL-1 and tumor necrosis factor by endothelial cells: role in stimulating fibroblast PGE2 synthesis.	Dinoprostone	98-102	interleukin 1 alpha	Homo sapiens	14-18
2512262-5	1989	PGE synthesis was also stimulated by the platelet-derived growth factor (PDGF), interleukin-1 (IL-1), or lipopolysaccharide (LPS).	Prostaglandins E	0-3	interleukin 1 alpha	Homo sapiens	80-99
2512262-6	1989	The amount of PGE synthesis after incubation with PDGF, LPS and IL-1 was comparable to that released after C5b-9.	Prostaglandins E	14-17	interleukin 1 alpha	Homo sapiens	64-68
2470907-6	1989	Likewise, exogenous IL 1 and anti Leu 4 antibody bound to Sepharose beads independently or cooperatively failed to propagate T cells from low responders.	Sepharose	58-67	interleukin 1 alpha	Homo sapiens	20-24
2674374-6	1989	IL-1 and TNF are known to be synergistic in stimulating fibroblast PGE2 synthesis.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	0-12
2674374-7	1989	Thus, elaboration of TNF by endothelial cells may allow detection of IL-1 in fibroblast PGE2 assays when the concentration of IL-1 is inadequate to stimulate thymocyte proliferation.	Dinoprostone	88-92	interleukin 1 alpha	Homo sapiens	69-73
2783320-10	1989	HuGi were incubated with H3 32PO4, stimulated with PMA or cytokines, and EGF-R were immunoprecipitated; IL-1 and TNF, like PMA, caused a 2- to 5-fold increase in receptor phosphorylation.	h3 32po4	25-33	interleukin 1 alpha	Homo sapiens	104-116
2654312-7	1989	The hypothesis based upon a decrease of fibrinogen synthesis seems very fascinating since pentoxifylline, inducing a decrease in Interleukin 1 activity on leukocytes, might be responsible also for a decrease in interleukin 1 activity as fibrinogen stimulating factor.	Pentoxifylline	90-104	interleukin 1 alpha	Homo sapiens	129-142
2654312-7	1989	The hypothesis based upon a decrease of fibrinogen synthesis seems very fascinating since pentoxifylline, inducing a decrease in Interleukin 1 activity on leukocytes, might be responsible also for a decrease in interleukin 1 activity as fibrinogen stimulating factor.	Pentoxifylline	90-104	interleukin 1 alpha	Homo sapiens	211-224
2527510-4	1989	The steady-state level of IL-1 alpha mRNA in these cells could be drastically increased by a short culture of the cells with the protein synthesis inhibitor cycloheximide or with PMA.	Cycloheximide	157-170	interleukin 1 alpha	Homo sapiens	26-36
2654314-3	1989	Adherence and peroxidative free radicals production are induced by inflammatory cytokines (IL1, TNF) and can induce vascular tissue damages and development of atherosclerosis.	Free Radicals	27-40	interleukin 1 alpha	Homo sapiens	91-94
2527510-4	1989	The steady-state level of IL-1 alpha mRNA in these cells could be drastically increased by a short culture of the cells with the protein synthesis inhibitor cycloheximide or with PMA.	Tetradecanoylphorbol Acetate	179-182	interleukin 1 alpha	Homo sapiens	26-36
2689826-2	1989	Since an enhanced rate of whole-body glucose utilization is a consistent feature of the hypermetabolic phase of infection, the purpose of the present study was to determine whether IL-1 could increase glucose uptake and whether that increase was dependent on the concomitant elevation in plasma insulin.	Glucose	201-208	interleukin 1 alpha	Homo sapiens	181-185
2565969-0	1989	Doxorubicin is a potent inhibitor of interleukin 1 induced cartilage proteoglycan resorption in-vitro.	Doxorubicin	0-11	interleukin 1 alpha	Homo sapiens	37-50
2565969-1	1989	Since interleukin 1 (IL-1) induces the transcriptional synthesis of enzymes responsible for cartilage resorption it was decided to examine the effects of the antitumour drug, doxorubicin, a DNA transcriptional inhibitor, on alpha IL-1-induced cartilage--resorption in-vitro.	Doxorubicin	175-186	interleukin 1 alpha	Homo sapiens	230-234
2565969-3	1989	Fine structure of the chondrocytes was preserved by the doxorubicin treatment with IL-1 in contrast to the extensive cellular destruction evident in cartilage treated with IL-1 alone.	Doxorubicin	56-67	interleukin 1 alpha	Homo sapiens	83-87
2565969-4	1989	[14C]doxorubicin was bound to cartilage proteoglycans, and this effect was promoted by treatment of the cartilage with IL-1.	Carbon-14	1-4	interleukin 1 alpha	Homo sapiens	119-123
2565969-4	1989	[14C]doxorubicin was bound to cartilage proteoglycans, and this effect was promoted by treatment of the cartilage with IL-1.	Doxorubicin	5-16	interleukin 1 alpha	Homo sapiens	119-123
2783617-0	1989	Phenytoin induces interleukin-1 production in vitro.	Phenytoin	0-9	interleukin 1 alpha	Homo sapiens	18-31
2783617-3	1989	The results showed that PHT induces Il-1 activity and potentiates LPS-induced Il-1 production.	Phenytoin	24-27	interleukin 1 alpha	Homo sapiens	36-40
2689826-7	1989	SRIF prevented the IL-1 induced increase in insulin and tissue glucose utilization.	Glucose	63-70	interleukin 1 alpha	Homo sapiens	19-23
2783617-3	1989	The results showed that PHT induces Il-1 activity and potentiates LPS-induced Il-1 production.	Phenytoin	24-27	interleukin 1 alpha	Homo sapiens	78-82
2689826-9	1989	These data suggest that the administration of IL-1 increases organ glucose utilization by insulin-dependent mechanisms.	Glucose	67-74	interleukin 1 alpha	Homo sapiens	46-50
2811473-1	1989	We have previously shown that interleukin-1 (IL-1) rapidly stimulates the hydrolysis of phosphatidylcholine in the human T lymphocyte cell line, Jurkat (Rosoff, et al., Cell 54: 73-81, 1988).	Phosphatidylcholines	88-107	interleukin 1 alpha	Homo sapiens	30-49
2569878-4	1989	Hybridization to 32P-labeled IL-1 alpha cDNA revealed an insertion-deletion-type polymorphic pattern.	Phosphorus-32	17-20	interleukin 1 alpha	Homo sapiens	29-39
2542734-7	1989	Taken collectively, these experiments support the notion that IL1 does not trigger IL2 gene activation per se, but amplifies the preactivated lymphokine genes initiated by PMA and ionomycin, whereas IL1 can activate the IL2 receptor gene without any other known signal requirements.	Tetradecanoylphorbol Acetate	172-175	interleukin 1 alpha	Homo sapiens	62-65
2542734-7	1989	Taken collectively, these experiments support the notion that IL1 does not trigger IL2 gene activation per se, but amplifies the preactivated lymphokine genes initiated by PMA and ionomycin, whereas IL1 can activate the IL2 receptor gene without any other known signal requirements.	Ionomycin	180-189	interleukin 1 alpha	Homo sapiens	62-65
2785698-0	1989	Interleukin-1 stimulates prostaglandin biosynthesis by human amnion.	Prostaglandins	25-38	interleukin 1 alpha	Homo sapiens	0-13
2507980-7	1989	Extracts from steam-autoclaved, dry-stored, or gamma-sterilised, wet-stored cuprophan and hemophan modules resulted in interleukin-1 activity that did not differ from negative controls.	cuprammonium cellulose	76-85	interleukin 1 alpha	Homo sapiens	119-132
2507980-7	1989	Extracts from steam-autoclaved, dry-stored, or gamma-sterilised, wet-stored cuprophan and hemophan modules resulted in interleukin-1 activity that did not differ from negative controls.	Hemophan	90-98	interleukin 1 alpha	Homo sapiens	119-132
2507980-8	1989	By contrast, extracts from cuprophan caused significant interleukin-1 production when prepared from ethylene oxide-sterilised, dry-stored dialysers.	cuprammonium cellulose	27-36	interleukin 1 alpha	Homo sapiens	56-69
2507980-8	1989	By contrast, extracts from cuprophan caused significant interleukin-1 production when prepared from ethylene oxide-sterilised, dry-stored dialysers.	Ethylene Oxide	100-114	interleukin 1 alpha	Homo sapiens	56-69
2507980-10	1989	Extensive rinsing of the module with water before extract preparation totally mitigated the in-vitro production of interleukin-1.	Water	37-42	interleukin 1 alpha	Homo sapiens	115-128
2788829-4	1989	Reserpine</protein-id>, which is known to deplete catecholamines, also caused release of the interleukin-1-like immunoreactive material.	Catecholamines	50-64	interleukin 1 alpha	Homo sapiens	93-106
2785698-1	1989	The purpose of these studies was to determine if Interleukin-1 (IL-1) alters the rate of prostaglandin biosynthesis by human amnion.	Prostaglandins	89-102	interleukin 1 alpha	Homo sapiens	49-62
2785698-1	1989	The purpose of these studies was to determine if Interleukin-1 (IL-1) alters the rate of prostaglandin biosynthesis by human amnion.	Prostaglandins	89-102	interleukin 1 alpha	Homo sapiens	64-68
2785698-4	1989	A concentration-dependent increase in PGE2 production by amnion cells occurred in response to natural purified and recombinant IL-1 preparations.	Dinoprostone	38-42	interleukin 1 alpha	Homo sapiens	127-131
2785698-6	1989	Indomethacin blocked the effect of IL-1 in prostaglandin biosynthesis by human amnion.	Indomethacin	0-12	interleukin 1 alpha	Homo sapiens	35-39
2785698-6	1989	Indomethacin blocked the effect of IL-1 in prostaglandin biosynthesis by human amnion.	Prostaglandins	43-56	interleukin 1 alpha	Homo sapiens	35-39
3144968-0	1988	Opposite effect of Interferon-gamma on PGE2 release from Interleukin-1-stimulated human monocytes or fibroblasts.	Dinoprostone	39-43	interleukin 1 alpha	Homo sapiens	57-70
2510238-5	1989	Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGF beta, IL-1 alpha and IFN-gamma, but less so by TGF alpha.	Glucose	25-32	interleukin 1 alpha	Homo sapiens	170-180
2510238-5	1989	Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGF beta, IL-1 alpha and IFN-gamma, but less so by TGF alpha.	fructose 2,6-diphosphate	102-127	interleukin 1 alpha	Homo sapiens	170-180
2510238-6	1989	Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-gamma.	Prostaglandins E	0-15	interleukin 1 alpha	Homo sapiens	58-68
2510238-6	1989	Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-gamma.	Prostaglandins E	253-256	interleukin 1 alpha	Homo sapiens	174-184
3144968-1	1988	Stimulated monocytes produce prostaglandins (PGE2) in response to lipopolysaccharide (LPS), Muramyl dipeptide (MDP) or Interleukin-1 (IL-1).	Prostaglandins	29-43	interleukin 1 alpha	Homo sapiens	119-138
3144968-1	1988	Stimulated monocytes produce prostaglandins (PGE2) in response to lipopolysaccharide (LPS), Muramyl dipeptide (MDP) or Interleukin-1 (IL-1).	Dinoprostone	45-49	interleukin 1 alpha	Homo sapiens	119-138
3144968-3	1988	This lymphokine, known to potentiate IL-1 production by LPS- or MDP-stimulated monocytes, suppressed different Il-1 activities such as PGE2 release by the same cells.	Dinoprostone	135-139	interleukin 1 alpha	Homo sapiens	111-115
2470624-3	1988	Furthermore, we also demonstrated that PTH-rP and IL-1 alpha (a potent osteoclast-activating factor) synergistically stimulated bone resorption in vitro and also synergistically increased serum calcium concentration in vivo.	Calcium	194-201	interleukin 1 alpha	Homo sapiens	50-60
3265268-2	1988	Interleukin-1 (IL-1) has been shown to induce inflammatory reactions in part through increased prostaglandin production.	Prostaglandins	95-108	interleukin 1 alpha	Homo sapiens	0-13
3265268-2	1988	Interleukin-1 (IL-1) has been shown to induce inflammatory reactions in part through increased prostaglandin production.	Prostaglandins	95-108	interleukin 1 alpha	Homo sapiens	15-19
3265268-5	1988	Natural IL-1 from human monocytes, IL-1 from glioblastoma cells as well as recombinant IL-1 alpha or beta, increased the pain reflex induced by acetylcholine in a concentration dependent manner.	Acetylcholine	144-157	interleukin 1 alpha	Homo sapiens	8-12
3265268-5	1988	Natural IL-1 from human monocytes, IL-1 from glioblastoma cells as well as recombinant IL-1 alpha or beta, increased the pain reflex induced by acetylcholine in a concentration dependent manner.	Acetylcholine	144-157	interleukin 1 alpha	Homo sapiens	35-39
3265268-5	1988	Natural IL-1 from human monocytes, IL-1 from glioblastoma cells as well as recombinant IL-1 alpha or beta, increased the pain reflex induced by acetylcholine in a concentration dependent manner.	Acetylcholine	144-157	interleukin 1 alpha	Homo sapiens	87-97
3265268-6	1988	The PGE2 levels were measured in the perfusate and were found to be enhanced more than 10-fold after the infusion of IL-1 alpha or IL-1 beta.	Dinoprostone	4-8	interleukin 1 alpha	Homo sapiens	117-127
3146356-1	1988	Recombinant human interleukin-1 (IL-1) inhibits the follicle-stimulating hormone (FSH)-induced development of luteinizing hormone (LH) receptors and suppresses progesterone secretion in cultured rat granulosa cells.	Progesterone	160-172	interleukin 1 alpha	Homo sapiens	18-37
3058540-11	1988	When the media were supplemented with growth factors, measurable increases in uptake of [3H]thymidine occurred with human epidermal growth factor (h-EGF), insulin-like growth factor-1 (IGF-1), nerve growth factor (NGF), transforming growth factor-beta (TGF-beta), bovine acidic fibroblast growth factor (baFGF), IL-1, bovine basic fibroblast growth factor (bbFGF), and Forskolin.	Tritium	89-91	interleukin 1 alpha	Homo sapiens	312-316
3264195-1	1988	Serial observations of blast cell colony development from spleen cells of mice treated with 5-fluorouracil (5-FU) four days earlier revealed that either form of human interleukin-1 (IL-1 alpha or IL-1 beta) hastens the emergence of interleukin-3 (IL-3)-dependent blast cell colonies.	Fluorouracil	92-106	interleukin 1 alpha	Homo sapiens	167-180
3264195-1	1988	Serial observations of blast cell colony development from spleen cells of mice treated with 5-fluorouracil (5-FU) four days earlier revealed that either form of human interleukin-1 (IL-1 alpha or IL-1 beta) hastens the emergence of interleukin-3 (IL-3)-dependent blast cell colonies.	Fluorouracil	92-106	interleukin 1 alpha	Homo sapiens	182-192
3264195-1	1988	Serial observations of blast cell colony development from spleen cells of mice treated with 5-fluorouracil (5-FU) four days earlier revealed that either form of human interleukin-1 (IL-1 alpha or IL-1 beta) hastens the emergence of interleukin-3 (IL-3)-dependent blast cell colonies.	Fluorouracil	108-112	interleukin 1 alpha	Homo sapiens	167-180
3264215-4	1988	It was found that the addition of IL-1, WEHI-3 supernatant, or CNF increased the frequency of DNP-responsive B cells suggesting an enhancement of clonal expansion.	2,4-Dinitrophenol	94-97	interleukin 1 alpha	Homo sapiens	34-38
3058540-11	1988	When the media were supplemented with growth factors, measurable increases in uptake of [3H]thymidine occurred with human epidermal growth factor (h-EGF), insulin-like growth factor-1 (IGF-1), nerve growth factor (NGF), transforming growth factor-beta (TGF-beta), bovine acidic fibroblast growth factor (baFGF), IL-1, bovine basic fibroblast growth factor (bbFGF), and Forskolin.	Thymidine	92-101	interleukin 1 alpha	Homo sapiens	312-316
3148377-10	1988	Furthermore, the partial maintenance of LPS-induced IL-1 production seen after cells were pre-incubated in gamma-IFN was markedly increased by the inclusion of 0.25 microgram/ml cycloheximide during the 24 h pre-incubation.	Cycloheximide	178-191	interleukin 1 alpha	Homo sapiens	52-56
3058540-12	1988	Measurable increases in uptake of [35S]sulfate into GAG occurred with IL-1, baFGF, TGF-beta, h-EGF, IGF-1, bbFGF, NGF, and Forskolin.	Sulfur-35	35-38	interleukin 1 alpha	Homo sapiens	70-74
3058540-12	1988	Measurable increases in uptake of [35S]sulfate into GAG occurred with IL-1, baFGF, TGF-beta, h-EGF, IGF-1, bbFGF, NGF, and Forskolin.	Sulfates	39-46	interleukin 1 alpha	Homo sapiens	70-74
3058540-12	1988	Measurable increases in uptake of [35S]sulfate into GAG occurred with IL-1, baFGF, TGF-beta, h-EGF, IGF-1, bbFGF, NGF, and Forskolin.	Glycosaminoglycans	52-55	interleukin 1 alpha	Homo sapiens	70-74
3148377-12	1988	Pre-incubation in gamma-IFN and cycloheximide leads to separate but synergistic effects on the maintenance of LPS-induced IL-1 production in cultured monocytes.	Cycloheximide	32-45	interleukin 1 alpha	Homo sapiens	122-126
3265388-0	1988	Glucocorticosteroid-dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation.	glucocorticosteroid	0-19	interleukin 1 alpha	Homo sapiens	46-59
3265388-9	1988	Moreover, glucocorticosteroids potentiate the synergistic effect of IL1 and IL6 on their B lymphocyte target, an effect comparable to that exerted on hepatocytes.	glucocorticosteroids	10-30	interleukin 1 alpha	Homo sapiens	68-71
2460462-0	1988	Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.	Phorbol Esters	0-13	interleukin 1 alpha	Homo sapiens	43-56
3263325-4	1988	Augmentation by interleukin-1 alpha of resistance to infection was also observed in P. aeruginosa-infected mice in a state of cyclophosphamide-induced leucopenia.	Cyclophosphamide	126-142	interleukin 1 alpha	Homo sapiens	16-35
3266612-1	1988	An antiserum to human interleukin 1 alpha has been prepared by immunizing a sheep with a short synthetic peptide (Mr 1427) conjugated to keyhole limpet haemocyanin using the heterobifunctional cross-linking agent N-succinimidyl bromoacetate.	N-succinimidyl bromoacetate	213-240	interleukin 1 alpha	Homo sapiens	22-41
3062144-5	1988	IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone.	Glucagon	102-110	interleukin 1 alpha	Homo sapiens	0-4
3062144-5	1988	IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone.	Corticosterone	115-129	interleukin 1 alpha	Homo sapiens	0-4
3264163-0	1988	Stimulation of interleukin-1 alpha and interleukin-1 beta release from human monocytes by cyanogen bromide peptides of type II collagen.	Cyanogen Bromide	90-106	interleukin 1 alpha	Homo sapiens	15-34
3266733-0	1988	Interleukin-1 stimulates proteoglycan and hyaluronic acid production by human gingival fibroblasts in vitro.	Hyaluronic Acid	42-57	interleukin 1 alpha	Homo sapiens	0-13
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Phorbol Esters	0-13	interleukin 1 alpha	Homo sapiens	134-138
3142527-3	1988	Recombinant IL-1 (10-100 U/ml) could stimulate cartilage resorption, although the maximum degree of tissue breakdown rarely reached the levels obtained when cartilage was treated with crude mononuclear-cell conditioned medium or all-trans retinoic acid (1 microM) over a similar time course.	Tretinoin	239-252	interleukin 1 alpha	Homo sapiens	12-16
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	15-51	interleukin 1 alpha	Homo sapiens	134-138
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 alpha	Homo sapiens	134-138
2460462-4	1988	These regulatory properties of TPA are also manifested in HepG2 cells transiently transfected with an indicator gene construct carrying the IL-1/IL-6 regulatory enhancer element of the rat alpha 1-acid glycoprotein gene.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 alpha	Homo sapiens	140-144
2460462-5	1988	IL-6 and IL-1 act independently of TPA-inducible kinase C, and of changes in intracellular Ca2+ concentrations.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 alpha	Homo sapiens	9-13
3263864-2	1988	Both forms of pig IL-1 and human IL-1 were separately equiactive in vitro in stimulating rabbit synovial fibroblasts and articular chondrocytes to synthesize prostaglandin E2 (PGE2).	Dinoprostone	176-180	interleukin 1 alpha	Homo sapiens	33-37
3263425-2	1988	In early studies we found that IL-1 stimulated endothelial cells (EC) to produce platelet-activating factor (PAF, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine).	Epitope ID:137482	114-158	interleukin 1 alpha	Homo sapiens	31-35
3263425-5	1988	Similarly, pre-treatment of PMN with PAF before the adhesion assay to induce desensitization to this phospholipid reduced PMN adhesion to IL-1-treated EC.	Phospholipids	101-113	interleukin 1 alpha	Homo sapiens	138-142
3263864-2	1988	Both forms of pig IL-1 and human IL-1 were separately equiactive in vitro in stimulating rabbit synovial fibroblasts and articular chondrocytes to synthesize prostaglandin E2 (PGE2).	Dinoprostone	158-174	interleukin 1 alpha	Homo sapiens	18-22
3264189-2	1988	IL-1 from supernatant of prodigiozan- + con A-stimulated monocytes had a MM of 18-20 KD and pI of 5.2-5.4 and 6.8 revealing an equal comitogenic activity and of 6.0 (minor peak).	prodigiozan- + con a	25-45	interleukin 1 alpha	Homo sapiens	0-4
3061746-4	1988	Prostaglandins exert immunosuppressive effects at several steps on both afferent and efferent phases in the cell-mediated immune system: reduction of Ia expression in antigen-presenting cells, inhibition of IL-1 and IL-2 production, and activation of suppressor cells.	Prostaglandins	0-14	interleukin 1 alpha	Homo sapiens	207-211
3263864-2	1988	Both forms of pig IL-1 and human IL-1 were separately equiactive in vitro in stimulating rabbit synovial fibroblasts and articular chondrocytes to synthesize prostaglandin E2 (PGE2).	Dinoprostone	158-174	interleukin 1 alpha	Homo sapiens	33-37
2844906-0	1988	IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.	Phosphatidylserines	65-83	interleukin 1 alpha	Homo sapiens	0-4
3263864-2	1988	Both forms of pig IL-1 and human IL-1 were separately equiactive in vitro in stimulating rabbit synovial fibroblasts and articular chondrocytes to synthesize prostaglandin E2 (PGE2).	Dinoprostone	176-180	interleukin 1 alpha	Homo sapiens	18-22
2460504-6	1988	Chemical crosslinking experiments identified a cell surface molecule of roughly 72,500 Mr that bound 125I-labeled IL-1, similar to the molecular weight of previously described IL-1 receptors on fibroblasts, B cells, and T cells.	Iodine-125	101-105	interleukin 1 alpha	Homo sapiens	114-118
2460504-6	1988	Chemical crosslinking experiments identified a cell surface molecule of roughly 72,500 Mr that bound 125I-labeled IL-1, similar to the molecular weight of previously described IL-1 receptors on fibroblasts, B cells, and T cells.	Iodine-125	101-105	interleukin 1 alpha	Homo sapiens	176-180
2844906-2	1988	The inhibition of the synthesis of this phospholipid could be partially reversed by IL-1.	Phospholipids	40-52	interleukin 1 alpha	Homo sapiens	84-88
2844906-4	1988	Furthermore, IL-1 did not modify the intracellular level of cGMP and cAMP, suggesting that the observed rise of PS synthesis could play the role of mediator IL-1 action.	Phosphatidylserines	112-114	interleukin 1 alpha	Homo sapiens	157-161
2844906-5	1988	As PS is a necessary cofactor for the activation of protein kinase C, our results suggest strongly that IL-1 modulate protein kinase C activity in the activated lymphocyte through its action on PS synthesis.	Phosphatidylserines	3-5	interleukin 1 alpha	Homo sapiens	104-108
3263853-5	1988	Measurement of RNA half life after addition of alpha-amanitin (an inhibitor of RNA polymerase II) indicate that IL-1 alpha mRNA is not as stable as IL-1 beta mRNA suggesting one mechanism for the different relative levels of RNA.	Alpha-Amanitin	47-61	interleukin 1 alpha	Homo sapiens	112-122
3263055-0	1988	Effect of indomethacin on febrile response to recombinant human interleukin 1-alpha in rabbits.	Indomethacin	10-22	interleukin 1 alpha	Homo sapiens	64-83
3263055-1	1988	Effects of indomethacin, a potent inhibitor of prostaglandin (PG) synthesis, on the fever induced by recombinant human interleukin 1-alpha (rhIL 1-alpha) was studied in conscious rabbits.	Indomethacin	11-23	interleukin 1 alpha	Homo sapiens	119-138
3263055-5	1988	It is suggested that PGs synthesized in the central nervous system contribute to the IL 1 fever and that part of IL 1-alpha given peripherally is also transmitted into the central nervous system to contribute to IL 1 fever.	Phosphatidylglycerols	21-24	interleukin 1 alpha	Homo sapiens	85-89
3048437-9	1988	In this system, the granulopoietic effect of IL-1 derives not from a direct effect on myeloid progenitors, but from its ability to recruit CSA production by other cells.	Cyclosporine	139-142	interleukin 1 alpha	Homo sapiens	45-49
3140819-2	1988	Gold sodium thiomalate (GST) inhibited both basal and interleukin-1-induced tritiated thymidine incorporation into fibroblasts in a dose- and time-dependent manner.	Gold Sodium Thiomalate	0-22	interleukin 1 alpha	Homo sapiens	54-67
3140819-2	1988	Gold sodium thiomalate (GST) inhibited both basal and interleukin-1-induced tritiated thymidine incorporation into fibroblasts in a dose- and time-dependent manner.	Thymidine	86-95	interleukin 1 alpha	Homo sapiens	54-67
3140820-0	1988	Stimulation of the hyaluronic acid levels of human synovial fibroblasts by recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta.	Hyaluronic Acid	19-34	interleukin 1 alpha	Homo sapiens	164-183
3140820-4	1988	We report here that recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta stimulate the hyaluronic acid (HA) levels of human synovial fibroblast-like cells.	Hyaluronic Acid	167-182	interleukin 1 alpha	Homo sapiens	109-128
3140820-4	1988	We report here that recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta stimulate the hyaluronic acid (HA) levels of human synovial fibroblast-like cells.	Hyaluronic Acid	184-186	interleukin 1 alpha	Homo sapiens	109-128
3048443-2	1988	Because erythroid burst-promoting activity (BPA) is also elaborated by endothelial cells exposed to IL-1, we sought to determine whether the BPA released by IL-1-induced endothelial cells simply reflects the known erythropoietic activity of GM-CSF or whether other uncharacterized factors might be involved.	bisphenol A	44-47	interleukin 1 alpha	Homo sapiens	100-104
3048443-3	1988	Media conditioned by multiply passaged endothelial cells cultured for three days with recombinant IL-1 alpha (ECMIL-1) stimulated erythroid burst and GM colony formation in cultures of human nonadherent T-lymphocyte-depleted marrow mononuclear cells.	gm	150-152	interleukin 1 alpha	Homo sapiens	98-108
3048443-8	1988	We conclude that GM-CSF is the BPA elaborated by IL-1-induced endothelial cells.	bisphenol A	31-34	interleukin 1 alpha	Homo sapiens	49-53
3262385-9	1988	These results indicate that IL-1 enhances the recovery of cells in LTBMC by stimulating the proliferation of HPC with the concurrent release of CSA from stromal cells, without diminishing the number of HPC.	Cyclosporine	144-147	interleukin 1 alpha	Homo sapiens	28-32
3046964-4	1988	Several studies have convincingly demonstrated that IL-1 is a potent modulator of beta-cell function and can potentiate or inhibit glucose-induced insulin secretion, depending on the concentration and length of exposure to IL-1.	Glucose	131-138	interleukin 1 alpha	Homo sapiens	52-56
2844418-6	1988	The stimulatory effect of SN from noninfected cultures in the IL-1 assay was reduced when SN from infected cultures was added, suggesting the presence of an IL-1 inhibitor.	Tin	26-28	interleukin 1 alpha	Homo sapiens	62-66
2844418-6	1988	The stimulatory effect of SN from noninfected cultures in the IL-1 assay was reduced when SN from infected cultures was added, suggesting the presence of an IL-1 inhibitor.	Tin	90-92	interleukin 1 alpha	Homo sapiens	62-66
3046964-4	1988	Several studies have convincingly demonstrated that IL-1 is a potent modulator of beta-cell function and can potentiate or inhibit glucose-induced insulin secretion, depending on the concentration and length of exposure to IL-1.	Glucose	131-138	interleukin 1 alpha	Homo sapiens	223-227
2971671-4	1988	Addition of exogenous (PGE1 and PGE2, also analogues of AMP, or forskolin increased the specific binding of 125I-IL 1 alpha to fibroblasts.	Colforsin	64-73	interleukin 1 alpha	Homo sapiens	113-123
2458983-7	1988	Pulse-labeling experiments with i.v.-administered 65Zn showed that IL 1 drastically altered zinc distribution kinetics among tissues.	Zinc-65	50-54	interleukin 1 alpha	Homo sapiens	67-71
2458983-8	1988	More 65Zn was taken up (and/or retained) by the liver, bone marrow, and thymus 6 h after IL 1, whereas correspondingly less 65Zn was found in bone, skin, and intestine.	Zinc-65	5-9	interleukin 1 alpha	Homo sapiens	89-93
2458983-10	1988	Chromatography of cytosol from tissues with increased 65Zn uptake suggests the IL 1-induced redistribution may be driven by enhanced metallothionein synthesis.	Zinc-65	54-58	interleukin 1 alpha	Homo sapiens	79-83
2971671-0	1988	Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s).	Prostaglandins	111-124	interleukin 1 alpha	Homo sapiens	0-13
2971671-3	1988	The IL 1 binding capability of the fibroblasts was restored to control levels by 16 h after removal of unbound IL 1, and then increased to about twofold over that of control cells by 48 h. This later enhancement of IL 1 receptor expression after IL 1 treatment was abolished by indomethacin.	Indomethacin	278-290	interleukin 1 alpha	Homo sapiens	4-8
2971671-4	1988	Addition of exogenous (PGE1 and PGE2, also analogues of AMP, or forskolin increased the specific binding of 125I-IL 1 alpha to fibroblasts.	Alprostadil	23-27	interleukin 1 alpha	Homo sapiens	113-123
2971671-6	1988	These data suggest that the later IL 1-induced up-regulation of IL 1R is mediated by IL 1 stimulation of endogenous prostaglandin production.	Prostaglandins	116-129	interleukin 1 alpha	Homo sapiens	34-38
2971671-4	1988	Addition of exogenous (PGE1 and PGE2, also analogues of AMP, or forskolin increased the specific binding of 125I-IL 1 alpha to fibroblasts.	Dinoprostone	32-36	interleukin 1 alpha	Homo sapiens	113-123
2971671-4	1988	Addition of exogenous (PGE1 and PGE2, also analogues of AMP, or forskolin increased the specific binding of 125I-IL 1 alpha to fibroblasts.	Adenosine Monophosphate	56-59	interleukin 1 alpha	Homo sapiens	113-123
2971671-6	1988	These data suggest that the later IL 1-induced up-regulation of IL 1R is mediated by IL 1 stimulation of endogenous prostaglandin production.	Prostaglandins	116-129	interleukin 1 alpha	Homo sapiens	64-68
2971724-7	1988	Furthermore, putrescine, a product of the ODC reaction and a precursor of polyamines, was able to overcome most, but not all, the antiproliferative action of IL-1 in A375 melanoma cells, which were the most sensitive to suppression by IL-1.	Putrescine	13-23	interleukin 1 alpha	Homo sapiens	158-162
2971724-7	1988	Furthermore, putrescine, a product of the ODC reaction and a precursor of polyamines, was able to overcome most, but not all, the antiproliferative action of IL-1 in A375 melanoma cells, which were the most sensitive to suppression by IL-1.	Putrescine	13-23	interleukin 1 alpha	Homo sapiens	235-239
2971724-7	1988	Furthermore, putrescine, a product of the ODC reaction and a precursor of polyamines, was able to overcome most, but not all, the antiproliferative action of IL-1 in A375 melanoma cells, which were the most sensitive to suppression by IL-1.	Polyamines	74-84	interleukin 1 alpha	Homo sapiens	158-162
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Cyclosporine	126-129	interleukin 1 alpha	Homo sapiens	16-20
3262792-0	1988	Effects of natural and recombinant interleukin-1 alpha and -beta on cytosolic free calcium in human and murine fibroblasts.	Calcium	83-90	interleukin 1 alpha	Homo sapiens	35-64
3262792-7	1988	IL-1 alpha and IL-1 beta both induced a dose-related increase in prostaglandin E2, but only in the human fibroblasts.	Dinoprostone	65-81	interleukin 1 alpha	Homo sapiens	0-10
3263122-0	1988	Elevation of PMN cytosolic free calcium and locomotion stimulated by novel peptides from IL-1-treated human synovial cell cultures.	Calcium	32-39	interleukin 1 alpha	Homo sapiens	89-93
3263122-1	1988	Treatment of human synovial cell cultures with human recombinant interleukin 1 (IL-1) results in the appearance of activity in the supernatant which stimulates human polymorphonuclear neutrophils (PMNs), as assessed by increased chemokinesis and elevation of intracellular free calcium concentration.	Calcium	278-285	interleukin 1 alpha	Homo sapiens	65-84
2457950-2	1988	Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 from human blood monocytes.	TFF2 protein, human	60-62	interleukin 1 alpha	Homo sapiens	91-133
3147981-8	1988	In the CD2 pathway, EGTA-inhibited proliferation of T cells could be completely restored by addition of exogenous interleukin 2 as well as exogenous recombinant interleukin 1.	Egtazic Acid	20-24	interleukin 1 alpha	Homo sapiens	161-174
2458149-6	1988	Anti-IL-1 antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-induced CSF production, suggesting that the latter effect was mediated by other mechanisms than IL-1 in supernatant.	Cyclosporine	71-74	interleukin 1 alpha	Homo sapiens	5-9
3147981-9	1988	Our results indicate that EGTA inhibits the production of interleukin 1 but has no direct effect on either interleukin 2 production or on Tac antigen expression.	Egtazic Acid	26-30	interleukin 1 alpha	Homo sapiens	58-71
2458149-6	1988	Anti-IL-1 antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-induced CSF production, suggesting that the latter effect was mediated by other mechanisms than IL-1 in supernatant.	Cyclosporine	71-74	interleukin 1 alpha	Homo sapiens	58-62
2458149-6	1988	Anti-IL-1 antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-induced CSF production, suggesting that the latter effect was mediated by other mechanisms than IL-1 in supernatant.	Cyclosporine	71-74	interleukin 1 alpha	Homo sapiens	58-62
2458149-8	1988	Poly(rI).poly(rC) appeared to be a better inducer for M-CSF than IL-1.	poly(ri	0-7	interleukin 1 alpha	Homo sapiens	65-69
3261237-4	1988	hCG-stimulated testosterone formation was markedly reduced by IL-1, with an ED50 of 1 U/ml.	Testosterone	15-27	interleukin 1 alpha	Homo sapiens	62-66
3266560-4	1988	However, the most relevant finding was that 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), the main NE metabolite, and the relation MHPG/NE were increased in all the regions studied, revealing a stimulatory effect of IL-1 on NE metabolism in the CNS.	Methoxyhydroxyphenylglycol	44-84	interleukin 1 alpha	Homo sapiens	219-223
3266560-4	1988	However, the most relevant finding was that 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), the main NE metabolite, and the relation MHPG/NE were increased in all the regions studied, revealing a stimulatory effect of IL-1 on NE metabolism in the CNS.	Methoxyhydroxyphenylglycol	86-90	interleukin 1 alpha	Homo sapiens	219-223
3266560-4	1988	However, the most relevant finding was that 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), the main NE metabolite, and the relation MHPG/NE were increased in all the regions studied, revealing a stimulatory effect of IL-1 on NE metabolism in the CNS.	Methoxyhydroxyphenylglycol	134-138	interleukin 1 alpha	Homo sapiens	219-223
3261237-5	1988	Basal testosterone production was slightly enhanced in the presence of low concentrations of IL-1, while high concentrations of IL-1 inhibited testosterone formation.	Testosterone	6-18	interleukin 1 alpha	Homo sapiens	93-97
3261237-5	1988	Basal testosterone production was slightly enhanced in the presence of low concentrations of IL-1, while high concentrations of IL-1 inhibited testosterone formation.	Testosterone	143-155	interleukin 1 alpha	Homo sapiens	128-132
3261237-6	1988	Significant inhibition of hCG-stimulated testosterone formation was noted as early as 8 h after the addition of IL-1.	Testosterone	41-53	interleukin 1 alpha	Homo sapiens	112-116
3261237-7	1988	IL-1 also inhibited hCG-stimulated cAMP formation, as well as 8-bromo-cAMP- and forskolin-stimulated testosterone synthesis.	Cyclic AMP	35-39	interleukin 1 alpha	Homo sapiens	0-4
3261237-9	1988	The inhibitory effects of IL-1 were reversed only partially by the addition of a cyclooxygenase inhibitor, indomethacin (0.1 mM), even though prostaglandin E2 formation was completely blocked.	Indomethacin	107-119	interleukin 1 alpha	Homo sapiens	26-30
3261237-9	1988	The inhibitory effects of IL-1 were reversed only partially by the addition of a cyclooxygenase inhibitor, indomethacin (0.1 mM), even though prostaglandin E2 formation was completely blocked.	Dinoprostone	142-158	interleukin 1 alpha	Homo sapiens	26-30
2842790-0	1988	Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.	Cyclic AMP	15-19	interleukin 1 alpha	Homo sapiens	87-100
2842790-2	1988	Our present study shows that exposure of human FS-4 fibroblasts to TNF or IL-1 caused a rapid accumulation of intracellular cAMP and an increase in protein kinase activity.	Cyclic AMP	124-128	interleukin 1 alpha	Homo sapiens	74-78
2842790-3	1988	Intracellular cAMP levels peaked 3-5 min after the addition of TNF or IL-1 and returned to basal level by 15 min.	Cyclic AMP	14-18	interleukin 1 alpha	Homo sapiens	70-74
3265135-8	1988	Statistically significant differences in IL1 production were observed between polymers, allowing their classification according to reactivity into high (Dacron, PE), intermediate (ePTFE) and low (Biomer, PDMS) reactive groups.	Polymers	78-86	interleukin 1 alpha	Homo sapiens	41-44
2901097-1	1988	Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner.	Dinoprostone	76-92	interleukin 1 alpha	Homo sapiens	18-37
2901097-1	1988	Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner.	Dinoprostone	76-92	interleukin 1 alpha	Homo sapiens	39-49
3136776-2	1988	It is now reported that MCCM, recombinant human IL-1 alpha (rHuIL-1 alpha), rHuIL-1 beta, and all-trans-retinoic acid elevate the u-PA messenger RNA (mRNA) levels to a steady-state value within 2 hours, while dexamethasone (10(-7)M) inhibits this increase.	Dexamethasone	209-222	interleukin 1 alpha	Homo sapiens	48-58
2969918-1	1988	In this report the binding of recombinant human interleukins 1 alpha and 1 beta (rIL-1 alpha and rIL-1 beta) to primary cultures of human rheumatoid synovial cells is measured and compared to the concentrations of these mediators required for stimulation of PGE2 production by these same cells.	Dinoprostone	258-262	interleukin 1 alpha	Homo sapiens	48-79
2969918-2	1988	The average concentration of IL-1 alpha required for half-maximal stimulation of PGE2 was 4.6 +/- 1.5 pM (+/- SEM) (n = 6), whereas for IL-1 beta half-maximal stimulation was observed at a concentration of 1.3 +/- 0.24 pM (n = 6).	Dinoprostone	81-85	interleukin 1 alpha	Homo sapiens	29-39
3262700-6	1988	However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased.	Poly C	56-63	interleukin 1 alpha	Homo sapiens	14-17
2458149-4	1988	Similar to IL-1, the synthetical double-stranded RNA poly(rI).poly(rC) also stimulated release of CSA by fibroblasts.	Cyclosporine	98-101	interleukin 1 alpha	Homo sapiens	11-15
3262700-6	1988	However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased.	Poly I	78-85	interleukin 1 alpha	Homo sapiens	14-17
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	35-43	interleukin 1 alpha	Homo sapiens	16-20
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Cyclosporine	52-55	interleukin 1 alpha	Homo sapiens	16-20
3262700-6	1988	However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased.	Poly C	56-62	interleukin 1 alpha	Homo sapiens	14-17
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	109-117	interleukin 1 alpha	Homo sapiens	16-20
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly I	32-39	interleukin 1 alpha	Homo sapiens	25-28
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly I	32-39	interleukin 1 alpha	Homo sapiens	171-174
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly C	40-47	interleukin 1 alpha	Homo sapiens	25-28
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly C	40-47	interleukin 1 alpha	Homo sapiens	171-174
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Cycloheximide	108-121	interleukin 1 alpha	Homo sapiens	25-28
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Cycloheximide	108-121	interleukin 1 alpha	Homo sapiens	171-174
2844218-7	1988	These results indicate that IL1 is responsible for the prostaglandin-independent bone resorbing activity synthesised by these cells in vitro, and may contribute to the bone destruction associated with the tumour.	Prostaglandins	55-68	interleukin 1 alpha	Homo sapiens	28-31
3260778-5	1988	Chondrocytes incubated with cycloheximide showed a first-order decrease in rate of uptake of radiolabelled sulphate (t1/2 = 25 mins) but interleukin 1 induced inhibition showed a delay of at least 1 hr, consistent with a requirement to deplete intracellular pools of protein before effects on post-translational events could be observed.	Cycloheximide	28-41	interleukin 1 alpha	Homo sapiens	137-150
3260779-4	1988	Combined treatment with the platelet-activating factor antagonist and inhibitors of prostaglandin synthesis nearly prevented interleukin 1-induced increases in vascular permeability or cellular infiltration.	Prostaglandins	84-97	interleukin 1 alpha	Homo sapiens	125-138
3260779-6	1988	Platelet-activating factor and prostaglandins may act synergistically as mediators of interleukin 1-induced vascular permeability.	Prostaglandins	31-45	interleukin 1 alpha	Homo sapiens	86-99
3262700-4	1988	To elucidate the mechanism of this inhibition, we examined the effect of IL1 on the synthesis of interferon-beta (IFN-beta), stimulated with polyinosinate.polycytidylate [poly(I).poly(C)].	polyinosinate	141-154	interleukin 1 alpha	Homo sapiens	73-76
3262700-5	1988	When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis.	Poly I	30-37	interleukin 1 alpha	Homo sapiens	61-64
3262700-5	1988	When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis.	Poly C	38-45	interleukin 1 alpha	Homo sapiens	61-64
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	156-158	interleukin 1 alpha	Homo sapiens	60-64
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	156-158	interleukin 1 alpha	Homo sapiens	41-45
2898301-0	1988	Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism.	Diglycerides	25-39	interleukin 1 alpha	Homo sapiens	0-13
3262452-4	1988	Incubation of rat aortas with human monocyte-derived interleukin 1 or recombinant human tumor necrosis factor resulted in diminished aortic contraction and sensitivity to norepinephrine, and gel filtration of medium conditioned by endotoxin-stimulated macrophages yielded suppressive activity at a molecular weight equivalent to interleukin 1 and tumor necrosis factor.	Norepinephrine	171-185	interleukin 1 alpha	Homo sapiens	53-66
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Diglycerides	82-96	interleukin 1 alpha	Homo sapiens	41-45
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Diglycerides	82-96	interleukin 1 alpha	Homo sapiens	60-64
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphorylcholine	101-118	interleukin 1 alpha	Homo sapiens	41-45
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphorylcholine	101-118	interleukin 1 alpha	Homo sapiens	60-64
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	135-154	interleukin 1 alpha	Homo sapiens	41-45
2898301-3	1988	Using highly purified, recombinant human IL-1, we show that IL-1 stimulates rapid diacylglycerol and phosphorylcholine production from phosphatidylcholine (PC) in the absence of phosphatidylinositol turnover in Jurkat cells.	Phosphatidylcholines	135-154	interleukin 1 alpha	Homo sapiens	60-64
3139548-1	1988	The combined effect of hydrocortisone (HC) and interferon-gamma and -alpha (IFN-gamma and -alpha) on human blood monocytes (Mo) interleukin 1 (IL 1) secretion was investigated.	Hydrocortisone	23-37	interleukin 1 alpha	Homo sapiens	107-147
2838424-0	1988	Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline.	Pentoxifylline	115-129	interleukin 1 alpha	Homo sapiens	41-88
3139548-3	1988	Hydrocortisone, at the pharmacological attainable concentration of 10(-5) molar (M), markedly suppressed fresh Mo IL 1 secretion but had no effect at lower tested doses.	Hydrocortisone	0-14	interleukin 1 alpha	Homo sapiens	114-118
3260615-3	1988	Endotoxin-contaminated dialysate fluid, sodium acetate as a dialysate buffer, and activated complement can induce IL-1 during hemodialysis.	Sodium Acetate	40-54	interleukin 1 alpha	Homo sapiens	114-118
3260615-5	1988	Incubation of MNC on sheets of two commonly used hemodialysis membranes, regenerated cellulose (RC) and polyacrylonitrile (PAN) resulted in significant induction of IL-1 in the absence of endotoxin or complement.	Cellulose	85-94	interleukin 1 alpha	Homo sapiens	165-169
3260615-5	1988	Incubation of MNC on sheets of two commonly used hemodialysis membranes, regenerated cellulose (RC) and polyacrylonitrile (PAN) resulted in significant induction of IL-1 in the absence of endotoxin or complement.	polyacrylonitrile	104-121	interleukin 1 alpha	Homo sapiens	165-169
3139906-0	1988	Cuprammonium membranes stimulate interleukin 1 release and arachidonic acid metabolism in monocytes in the absence of complement.	cuprammonium	0-12	interleukin 1 alpha	Homo sapiens	33-46
3139906-5	1988	The results show that in absence of C, brief (2 min) contact with cuprammonium (CU) stimulated: (a) PGE2 release in U937 and human monocytes or GEC; (b) TXB2 release in washed platelets; (c) slow interleukin 1 release by monocytes; and (d) generation of O2- radicals in PMN.	cuprammonium	66-78	interleukin 1 alpha	Homo sapiens	196-209
3139906-5	1988	The results show that in absence of C, brief (2 min) contact with cuprammonium (CU) stimulated: (a) PGE2 release in U937 and human monocytes or GEC; (b) TXB2 release in washed platelets; (c) slow interleukin 1 release by monocytes; and (d) generation of O2- radicals in PMN.	Copper	80-82	interleukin 1 alpha	Homo sapiens	196-209
2845482-4	1988	Recombinant human interleukin-1 (rhIL-1) also promoted the production of cervical collagenase independently of endogenous prostaglandin(s).	Prostaglandins	122-135	interleukin 1 alpha	Homo sapiens	18-39
3266876-0	1988	Interleukin-1 production from monocyte induced by urate crystals.	Uric Acid	50-55	interleukin 1 alpha	Homo sapiens	0-13
3259727-0	1988	Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.	Glucose	34-41	interleukin 1 alpha	Homo sapiens	18-22
3138125-6	1988	However, silica-stimulated IL 1 release was normal in patients with newly diagnosed or short-term disease, but was significantly decreased in long-term diabetics.	Silicon Dioxide	9-15	interleukin 1 alpha	Homo sapiens	27-31
3391643-7	1988	Furthermore, PHA-stimulated monocytes exposed to O2 produced more IL-1 than control cells.	Oxygen	49-51	interleukin 1 alpha	Homo sapiens	66-70
3260254-4	1988	Activated tumoricidal macrophages fixed in 2% paraformaldehyde lysed only the TNF- and IL-1-sensitive A375 cells.	paraform	46-62	interleukin 1 alpha	Homo sapiens	87-91
3260255-1	1988	TNF-alpha and IL-1 induce the production of PGE2 from human chondrosarcoma, fibrosarcoma, and carcinoma cell lines.	Dinoprostone	44-48	interleukin 1 alpha	Homo sapiens	14-18
3260255-2	1988	When combined at sub-optimal concentrations, TNF-alpha and IL-1 synergistically stimulate PGE2 production.	Dinoprostone	90-94	interleukin 1 alpha	Homo sapiens	59-63
3260255-3	1988	The synergy of TNF-alpha and IL-1 on the induction of PGE2 is partially neutralized by specific antibodies.	Dinoprostone	54-58	interleukin 1 alpha	Homo sapiens	29-33
2967196-0	1988	Gonadal steroids modulate human monocyte interleukin-1 (IL-1) activity.	Steroids	8-16	interleukin 1 alpha	Homo sapiens	41-54
2967196-0	1988	Gonadal steroids modulate human monocyte interleukin-1 (IL-1) activity.	Steroids	8-16	interleukin 1 alpha	Homo sapiens	56-60
2967196-1	1988	Interleukin-1 (IL-1), a monocyte and macrophage product, is the mediator of a wide variety of immune responses, including fever, and increases during the luteal phase of the menstrual cycle, concomitantly with progesterone (P).	Progesterone	210-222	interleukin 1 alpha	Homo sapiens	0-13
2967196-1	1988	Interleukin-1 (IL-1), a monocyte and macrophage product, is the mediator of a wide variety of immune responses, including fever, and increases during the luteal phase of the menstrual cycle, concomitantly with progesterone (P).	Progesterone	210-222	interleukin 1 alpha	Homo sapiens	15-19
2967196-7	1988	Thus, human peripheral monocyte IL-1 activity appears to be modulated by gonadal steroids; however, a reciprocal relationship between IL-1 and gonadal steroidogenesis was not observed.	Steroids	81-89	interleukin 1 alpha	Homo sapiens	32-36
3391643-11	1988	By contrast, exposure to O2 induced increases in the production of both IL-1 and IL-2 that may not be related to alterations in the thiol status of the cell.	Oxygen	25-27	interleukin 1 alpha	Homo sapiens	72-76
3131752-5	1988	Prostaglandin E2 is the neural mediator of fever induced by IL-1, so fever can be suppressed by drugs that interfere with prostaglandin synthesis.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	60-64
2971110-2	1988	A lower response was obtained with PS-containing supernatants, suggesting that PS exerts its suppressive effect by inhibiting IL-1 synthesis or by blocking its mode of action.	ps	35-37	interleukin 1 alpha	Homo sapiens	126-130
2971110-3	1988	IL-1 activity generated by human peripheral blood mononuclear cells (PBMC) stimulated with LPS and cultured in the presence of PS or NHS was similar.	ps	92-94	interleukin 1 alpha	Homo sapiens	0-4
2971110-3	1988	IL-1 activity generated by human peripheral blood mononuclear cells (PBMC) stimulated with LPS and cultured in the presence of PS or NHS was similar.	N-hydroxysuccinimide	133-136	interleukin 1 alpha	Homo sapiens	0-4
2971110-4	1988	However, when PS was present, the proliferation of thymocytes co-mitogenically stimulated with PHA and exogenous IL-1 was diminished compared with the control (NHS), exhibiting its maximum inhibition when PS was added at the highest concentration and at the beginning of the incubation period.	ps	14-16	interleukin 1 alpha	Homo sapiens	113-117
2971110-4	1988	However, when PS was present, the proliferation of thymocytes co-mitogenically stimulated with PHA and exogenous IL-1 was diminished compared with the control (NHS), exhibiting its maximum inhibition when PS was added at the highest concentration and at the beginning of the incubation period.	ps	205-207	interleukin 1 alpha	Homo sapiens	113-117
2971110-5	1988	The suppressive effect of PS in the thymocyte assay disappeared with the combined action of exogenous IL-1 and IL-2.	ps	26-28	interleukin 1 alpha	Homo sapiens	102-106
2971110-7	1988	These results indicate that PS was interfering with IL-1 activity by rendering IL-2-producer cells unable to synthesize IL-2 and subsequently to proliferate.	ps	28-30	interleukin 1 alpha	Homo sapiens	52-56
3131752-5	1988	Prostaglandin E2 is the neural mediator of fever induced by IL-1, so fever can be suppressed by drugs that interfere with prostaglandin synthesis.	Prostaglandins	122-135	interleukin 1 alpha	Homo sapiens	60-64
3260420-0	1988	Inhibition of parathyroid hormone and interleukin 1-stimulated bone resorption by cyclosporine A but not by cyclosporine H or F.	Cyclosporine	82-96	interleukin 1 alpha	Homo sapiens	38-51
2839894-6	1988	Moreover, the finding that after silica stimulation the amount of membrane-associated IL-1 (which was recently shown to be of the IL-1 alpha type) was low, while IL-1 alpha in the culture fluid was clearly elevated, suggests that the IL-1 alpha not attached to the cell membrane (or released from it) significantly contributes to the secreted IL-1 pool.	Silicon Dioxide	33-39	interleukin 1 alpha	Homo sapiens	130-140
2844146-2	1988	Addition of 0.05-5 ng of IL-1/ml into the cultures resulted in a dose-dependent decreased rate of collagen released into the medium over 24 h. To determine whether this inhibition was due to secondary action of prostaglandin E2 (PGE2) secreted in response to IL-1, cultures were incubated in presence of various inhibitors of arachidonate metabolism.	Dinoprostone	211-227	interleukin 1 alpha	Homo sapiens	25-29
3261603-3	1988	32P-Labeled pp 65 was purified to homogeneity from the cytosol fraction of IL 1 stimulated [32P]orthophosphate-labeled PBMC by sequential chromatography on Sephacryl S-200, high-performance liquid chromatography (HPLC) anion exchange, and hydroxyapatite HPLC.	Phosphorus-32	0-3	interleukin 1 alpha	Homo sapiens	75-79
3261603-3	1988	32P-Labeled pp 65 was purified to homogeneity from the cytosol fraction of IL 1 stimulated [32P]orthophosphate-labeled PBMC by sequential chromatography on Sephacryl S-200, high-performance liquid chromatography (HPLC) anion exchange, and hydroxyapatite HPLC.	Phosphorus-32	92-95	interleukin 1 alpha	Homo sapiens	75-79
3261603-3	1988	32P-Labeled pp 65 was purified to homogeneity from the cytosol fraction of IL 1 stimulated [32P]orthophosphate-labeled PBMC by sequential chromatography on Sephacryl S-200, high-performance liquid chromatography (HPLC) anion exchange, and hydroxyapatite HPLC.	Phosphates	96-110	interleukin 1 alpha	Homo sapiens	75-79
3261603-3	1988	32P-Labeled pp 65 was purified to homogeneity from the cytosol fraction of IL 1 stimulated [32P]orthophosphate-labeled PBMC by sequential chromatography on Sephacryl S-200, high-performance liquid chromatography (HPLC) anion exchange, and hydroxyapatite HPLC.	PBMC	119-123	interleukin 1 alpha	Homo sapiens	75-79
3261603-3	1988	32P-Labeled pp 65 was purified to homogeneity from the cytosol fraction of IL 1 stimulated [32P]orthophosphate-labeled PBMC by sequential chromatography on Sephacryl S-200, high-performance liquid chromatography (HPLC) anion exchange, and hydroxyapatite HPLC.	Durapatite	239-253	interleukin 1 alpha	Homo sapiens	75-79
2844146-3	1988	Depending on the cell strains, these inhibitors were able to suppress or diminish the effect of IL-1, suggesting that PGE2 is involved in the mechanism.	Dinoprostone	118-122	interleukin 1 alpha	Homo sapiens	96-100
2844146-2	1988	Addition of 0.05-5 ng of IL-1/ml into the cultures resulted in a dose-dependent decreased rate of collagen released into the medium over 24 h. To determine whether this inhibition was due to secondary action of prostaglandin E2 (PGE2) secreted in response to IL-1, cultures were incubated in presence of various inhibitors of arachidonate metabolism.	Dinoprostone	229-233	interleukin 1 alpha	Homo sapiens	25-29
2844146-2	1988	Addition of 0.05-5 ng of IL-1/ml into the cultures resulted in a dose-dependent decreased rate of collagen released into the medium over 24 h. To determine whether this inhibition was due to secondary action of prostaglandin E2 (PGE2) secreted in response to IL-1, cultures were incubated in presence of various inhibitors of arachidonate metabolism.	Arachidonic Acid	326-338	interleukin 1 alpha	Homo sapiens	25-29
3130394-3	1988	Treatment of HuVEC with interleukin 1, tumor necrosis factor (TNF), bacterial endotoxin, and 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in time and dose-dependent increases of adhesiveness for basophils.	Tetradecanoylphorbol Acetate	93-129	interleukin 1 alpha	Homo sapiens	24-60
2452833-3	1988	We have employed monoclonal antibody anti-T3B covalently coupled to CnBr-activated Sepharose 4B beads, to show that multimeric ligation of T cell antigen receptor leads to T cell receptiveness to interleukin 1 (IL-1), as indicated by T cell production of CSF, which induces growth of myeloid progenitor cells into neutrophil, eosinophil, and monocyte colonies.	Sepharose	83-95	interleukin 1 alpha	Homo sapiens	196-209
3130394-3	1988	Treatment of HuVEC with interleukin 1, tumor necrosis factor (TNF), bacterial endotoxin, and 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in time and dose-dependent increases of adhesiveness for basophils.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 alpha	Homo sapiens	24-60
3261833-2	1988	Since beta IL-1 is the predominant species in human monocytes, this study was undertaken to identify its mRNA in monocytes using in situ hybridization with a 35S-dCTP labelled beta IL-1 cDNA probe.	35s-dctp	158-166	interleukin 1 alpha	Homo sapiens	181-185
2971135-3	1988	Initial studies, conducted with MCF-7 cells, demonstrated that both forms of recombinant human IL-1 (alpha and beta) at 10(-11) M inhibited [3H]thymidine uptake by MCF-7 by 70%, and by day 7 of the long-term study alpha and beta IL-1 at 10(-11) M inhibited MCF-7 cell growth by 80%.	Tritium	141-143	interleukin 1 alpha	Homo sapiens	95-115
2971135-3	1988	Initial studies, conducted with MCF-7 cells, demonstrated that both forms of recombinant human IL-1 (alpha and beta) at 10(-11) M inhibited [3H]thymidine uptake by MCF-7 by 70%, and by day 7 of the long-term study alpha and beta IL-1 at 10(-11) M inhibited MCF-7 cell growth by 80%.	Tritium	141-143	interleukin 1 alpha	Homo sapiens	95-99
3134688-10	1988	It was demonstrated that naproxen (Naprosyne 500) seems to antagonize the inhibiting action of IL1 on the production of collagen, the main component of cartilage.	Naproxen	25-33	interleukin 1 alpha	Homo sapiens	95-98
2897711-0	1988	Histamine inhibits interleukin 1 production by lipopolysaccharide-stimulated human peripheral blood monocytes.	Histamine	0-9	interleukin 1 alpha	Homo sapiens	19-32
2897711-1	1988	Histamine inhibited the production of interleukin 1 (IL-1) induced by lipopolysaccharide (LPS) in cultures of purified human peripheral blood monocytes.	Histamine	0-9	interleukin 1 alpha	Homo sapiens	38-57
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	Histamine	14-23	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	Histamine	14-23	interleukin 1 alpha	Homo sapiens	303-307
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	Histamine	81-90	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	Dimaprit	161-169	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	4-methylhistamine	174-191	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	2-(2-aminoethyl)pyridine	226-245	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	aminoethylthiazole	247-265	interleukin 1 alpha	Homo sapiens	27-31
3134688-10	1988	It was demonstrated that naproxen (Naprosyne 500) seems to antagonize the inhibiting action of IL1 on the production of collagen, the main component of cartilage.	Naproxen	35-44	interleukin 1 alpha	Homo sapiens	95-98
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	2-methylhistamine	270-287	interleukin 1 alpha	Homo sapiens	27-31
2897711-2	1988	The effect of histamine on IL-1 production was dose-dependent and significant at histamine concentrations of 10(-4)-10(-5) M. The histamine H2 receptor agonists dimaprit and 4-methylhistamine, but not the H1 receptor agonists 2-pyridylethylamine, aminoethylthiazole and 2-methylhistamine, modulated the IL-1 production in a similar manner to histamine.	Histamine	81-90	interleukin 1 alpha	Homo sapiens	27-31
3258338-3	1988	Different brands and lots of polystyrene culture wells give rise to great variation in IL-1 production.	Polystyrenes	29-40	interleukin 1 alpha	Homo sapiens	87-91
2897711-4	1988	This indicates that the inhibitory effects of histamine on LPS-induced IL-1 production are mediated through H2 receptors on human peripheral blood monocytes.	Histamine	46-55	interleukin 1 alpha	Homo sapiens	71-75
3260869-2	1988	Recombinant human interleukin-1 alpha (rHu-IL-1 alpha) inhibited writhing dose relatedly at doses of 0.25-5 micrograms/kg i.v., and its potency was about 1000 times that of morphine on a molar basis.	Morphine	173-181	interleukin 1 alpha	Homo sapiens	18-37
2966074-0	1988	Site directed mutants of human interleukin-1 alpha: a 1H-NMR and receptor binding study.	Hydrogen	54-56	interleukin 1 alpha	Homo sapiens	31-50
2966074-1	1988	Mutant human interleukin-1 alpha proteins were constructed by oligonucleotide directed mutagenesis.	Oligonucleotides	62-77	interleukin 1 alpha	Homo sapiens	13-32
2832052-0	1988	Requirement of differentiative signals of both interferon-gamma and 1,25-dihydroxyvitamin D3 for induction and secretion of interleukin-1 by HL-60 cells.	Calcitriol	68-92	interleukin 1 alpha	Homo sapiens	124-137
2838419-0	1988	Recombinant interleukin 1 alpha and beta prime human monocyte superoxide production but have no effect on chemotaxis and oxidative burst response of neutrophils.	Superoxides	62-72	interleukin 1 alpha	Homo sapiens	12-31
3257934-4	1988	Lysates of monocytes from patients also contained more interleukin-1 than those of controls (p less than 0.05) in the presence of lipopolysaccharide or silica, or both.	Silicon Dioxide	152-158	interleukin 1 alpha	Homo sapiens	55-68
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Superoxides	105-115	interleukin 1 alpha	Homo sapiens	46-56
3259542-0	1988	1 alpha,25-Dihydroxyvitamin D3 and a novel vitamin D analogue MC 903 are potent inhibitors of human interleukin 1 in vitro.	Calcitriol	0-30	interleukin 1 alpha	Homo sapiens	100-113
3259542-0	1988	1 alpha,25-Dihydroxyvitamin D3 and a novel vitamin D analogue MC 903 are potent inhibitors of human interleukin 1 in vitro.	Vitamin D	20-29	interleukin 1 alpha	Homo sapiens	100-113
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Tetradecanoylphorbol Acetate	152-155	interleukin 1 alpha	Homo sapiens	46-56
3259542-0	1988	1 alpha,25-Dihydroxyvitamin D3 and a novel vitamin D analogue MC 903 are potent inhibitors of human interleukin 1 in vitro.	calcipotriene	62-68	interleukin 1 alpha	Homo sapiens	100-113
3258335-13	1988	Although the precise role of the rather selective phosphorylation of pre-IL-1 alpha is not known, our findings do suggest that the phosphorylation of serine close to dibasic/tetrabasic amino acid sequence functions to facilitate the processing and/or release of IL-1 alpha.	Serine	150-156	interleukin 1 alpha	Homo sapiens	262-272
3259542-2	1988	Since its production is dependent upon interleukin 1 (IL-1) produced by antigen-presenting cells, we tested five vitamin D3 analogues for effects on the production and function of human natural and recombinant IL-1.	Cholecalciferol	113-123	interleukin 1 alpha	Homo sapiens	54-58
3259542-5	1988	1,25(OH)2D3 may play a physiological immunomodulatory role as a selective inhibitor of the function of IL-1, and MC 903 may prove clinically useful in this regard because of its limited calcium metabolic activity.	Calcitriol	0-11	interleukin 1 alpha	Homo sapiens	103-107
3142218-7	1988	Neither clone produced prostaglandin E (PGE), leukotriene B4 (LTB4), or tumor necrosis factor (TNF) but IL1 alpha production by 1.3 could be influenced by exogenous PGE and TNF.	Prostaglandins E	165-168	interleukin 1 alpha	Homo sapiens	104-113
3131173-2	1988	The present study was designed to examine if the reduction of FSH-stimulated 125I-labeled hCG binding by IL 1 was caused by a decline in the binding capacity or by an alteration in the affinity of the LH receptor and, further, to determine the minimum period of exposure of the granulosa cells to IL 1 necessary to suppress 125I-labeled hCG binding.	Iodine-125	77-81	interleukin 1 alpha	Homo sapiens	105-109
2969245-3	1988	The contribution of IL 1 to local inflammatory reactions is influenced by exogenous stimuli, antagonists such as steroid hormones and TGF beta (tissue growth factor beta) and agonists such as TNF (tissue necrosis factor).	Steroids	113-129	interleukin 1 alpha	Homo sapiens	20-24
3131173-2	1988	The present study was designed to examine if the reduction of FSH-stimulated 125I-labeled hCG binding by IL 1 was caused by a decline in the binding capacity or by an alteration in the affinity of the LH receptor and, further, to determine the minimum period of exposure of the granulosa cells to IL 1 necessary to suppress 125I-labeled hCG binding.	Iodine-125	324-328	interleukin 1 alpha	Homo sapiens	105-109
3257992-2	1988	From 10(-5) to 10(-8) M glucocorticoid hormone (prednisolone) inhibited both IL-1 alpha and IL-1 beta production by LPS-stimulated adherent human PBMC in a dose-dependent fashion, as assayed by Western blotting of cell-associated IL-1 and a thymocyte comitogenic bioassay.	Prednisolone	48-60	interleukin 1 alpha	Homo sapiens	77-87
3128273-1	1988	Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2].	Glucose	206-213	interleukin 1 alpha	Homo sapiens	26-51
3126028-2	1988	Its most dramatic biological property is its ability to induce arachidonate metabolites in a variety of cells including PGE in the brain, fibroblasts, synovial cells, and chondrocytes; in addition, IL-1 induces lipoxygenase products in lymphocytes and other cells.	Arachidonic Acid	63-75	interleukin 1 alpha	Homo sapiens	198-202
3126028-10	1988	IL-1 induces prostaglandins and lymphocyte activation as well as many different biological activities.	Prostaglandins	13-27	interleukin 1 alpha	Homo sapiens	0-4
3125257-2	1988	We describe here a new IL-1 titration method which takes advantage of the capacity of a thymoma line, EL4-6.1, to differentiate and express IL-2 receptors upon stimulation by IL-1 in the presence of a suboptimal dose of phorbol diester.	Phorbol Esters	220-235	interleukin 1 alpha	Homo sapiens	23-27
3128273-1	1988	Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2].	Lactic Acid	222-229	interleukin 1 alpha	Homo sapiens	26-51
3128273-3	1988	Prostaglandin E production was stimulated predominantly by IL1 alpha and IL1 beta rather than by IFN-gamma or TNF alpha.	Prostaglandins E	0-15	interleukin 1 alpha	Homo sapiens	59-68
3257168-0	1988	Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin.	Indomethacin	71-83	interleukin 1 alpha	Homo sapiens	48-67
2447983-5	1988	A second IL 1 pulse induced CSA release in an identical manner, as did the primary stimulation, indicating that the CSA released was actively produced.	Cyclosporine	28-31	interleukin 1 alpha	Homo sapiens	9-13
2447983-5	1988	A second IL 1 pulse induced CSA release in an identical manner, as did the primary stimulation, indicating that the CSA released was actively produced.	Cyclosporine	116-119	interleukin 1 alpha	Homo sapiens	9-13
3257168-1	1988	In murine syngeneic tumor models, the antitumor effect of recombinant human interleukin-1 alpha (rHu IL-1 alpha) was significantly augmented by oral coadministration of indomethacin (IND).	Indomethacin	169-181	interleukin 1 alpha	Homo sapiens	76-95
3257168-1	1988	In murine syngeneic tumor models, the antitumor effect of recombinant human interleukin-1 alpha (rHu IL-1 alpha) was significantly augmented by oral coadministration of indomethacin (IND).	Indomethacin	169-181	interleukin 1 alpha	Homo sapiens	101-111
3257168-1	1988	In murine syngeneic tumor models, the antitumor effect of recombinant human interleukin-1 alpha (rHu IL-1 alpha) was significantly augmented by oral coadministration of indomethacin (IND).	Indomethacin	183-186	interleukin 1 alpha	Homo sapiens	76-95
3257168-1	1988	In murine syngeneic tumor models, the antitumor effect of recombinant human interleukin-1 alpha (rHu IL-1 alpha) was significantly augmented by oral coadministration of indomethacin (IND).	Indomethacin	183-186	interleukin 1 alpha	Homo sapiens	101-111
3257168-3	1988	This results suggests that prostaglandin E2 produced by host cells in response to rHu IL-1 alpha and/or by tumor mass might interfere with the antitumor activity of rHu IL-1 alpha and also that cyclooxygenase inhibitors such as IND might counteract such interference.	Dinoprostone	27-43	interleukin 1 alpha	Homo sapiens	86-96
3257168-3	1988	This results suggests that prostaglandin E2 produced by host cells in response to rHu IL-1 alpha and/or by tumor mass might interfere with the antitumor activity of rHu IL-1 alpha and also that cyclooxygenase inhibitors such as IND might counteract such interference.	Dinoprostone	27-43	interleukin 1 alpha	Homo sapiens	169-179
3257168-3	1988	This results suggests that prostaglandin E2 produced by host cells in response to rHu IL-1 alpha and/or by tumor mass might interfere with the antitumor activity of rHu IL-1 alpha and also that cyclooxygenase inhibitors such as IND might counteract such interference.	Indomethacin	228-231	interleukin 1 alpha	Homo sapiens	86-96
3257168-3	1988	This results suggests that prostaglandin E2 produced by host cells in response to rHu IL-1 alpha and/or by tumor mass might interfere with the antitumor activity of rHu IL-1 alpha and also that cyclooxygenase inhibitors such as IND might counteract such interference.	Indomethacin	228-231	interleukin 1 alpha	Homo sapiens	169-179
3257168-5	1988	In addition, IND partially prevented the loss of body weight attributed to rHu IL-1 alpha injections at relatively high doses.	Indomethacin	13-16	interleukin 1 alpha	Homo sapiens	79-89
3277884-9	1988	IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites.	Arachidonic Acid	72-88	interleukin 1 alpha	Homo sapiens	0-4
3257444-9	1988	A significant rise in CSA occurred between 3 and 6 h after injection of purified IL-1, and a significant increase in BM CFU-GM developed 48 h after injection.	Cyclosporine	22-25	interleukin 1 alpha	Homo sapiens	81-85
3276731-0	1988	Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.	Prostaglandins	110-121	interleukin 1 alpha	Homo sapiens	0-13
2828381-12	1988	These observations support the notion that IL-1 alpha and beta may both modulate the degradation of collagen at sites of tissue injury by virtue of their ability to stimulate collagenase and PGE2 production by fibroblasts.	Dinoprostone	191-195	interleukin 1 alpha	Homo sapiens	43-53
3264990-0	1988	Does interleukin-1 affect intracellular calcium in osteoblast-like cells (UMR-106)?	Calcium	40-47	interleukin 1 alpha	Homo sapiens	5-18
3264990-2	1988	We investigated the possibility that the effect of IL-1 on osteoblasts is mediated through an increase in intracellular calcium [Ca++]i by studying the effects of purified human monocyte-derived IL-1 (hIL-1) and recombinant human IL-1 alpha (rhIL alpha) and beta (rhIL-1 beta) on [Ca++]i in the rat osteogenic sarcoma cell line UMR 106 using indo-1, a new-generation fluorescent Ca++-sensitive probe.	Calcium	120-127	interleukin 1 alpha	Homo sapiens	51-55
3276731-4	1988	IL-1 did stimulate SMC to produce prostanoids such as PGE1 or PGE2 that can inhibit SMC proliferation.	Prostaglandins	34-45	interleukin 1 alpha	Homo sapiens	0-4
3264990-4	1988	A similar transient rise in calcium was obtained upon exposure of the UMR cells to both the hIL-1 suspension buffer and to the concentration of fetal bovine serum present in the hIL-1 buffer.	Calcium	28-35	interleukin 1 alpha	Homo sapiens	92-97
3264990-4	1988	A similar transient rise in calcium was obtained upon exposure of the UMR cells to both the hIL-1 suspension buffer and to the concentration of fetal bovine serum present in the hIL-1 buffer.	Calcium	28-35	interleukin 1 alpha	Homo sapiens	178-183
3276731-4	1988	IL-1 did stimulate SMC to produce prostanoids such as PGE1 or PGE2 that can inhibit SMC proliferation.	Alprostadil	54-58	interleukin 1 alpha	Homo sapiens	0-4
3276731-4	1988	IL-1 did stimulate SMC to produce prostanoids such as PGE1 or PGE2 that can inhibit SMC proliferation.	Dinoprostone	62-66	interleukin 1 alpha	Homo sapiens	0-4
3276731-11	1988	Endogenous prostanoid production simultaneously induced by IL-1 appears to antagonize this growth-promoting effect in the short term (2 d) but not during more prolonged exposures.	Prostaglandins	11-21	interleukin 1 alpha	Homo sapiens	59-63
3276786-6	1988	The enhancing effect of IL-1 alpha on IFN-beta 2 gene transcription, but not that of TNF, PDGF, or IFN-beta 1, is inhibited by cycloheximide, suggesting that newly-synthesized protein is involved in the increase in IFN-beta 2 transcription in response to IL-1 alpha but not in the response to the other stimuli.	Cycloheximide	127-140	interleukin 1 alpha	Homo sapiens	24-34
3276786-6	1988	The enhancing effect of IL-1 alpha on IFN-beta 2 gene transcription, but not that of TNF, PDGF, or IFN-beta 1, is inhibited by cycloheximide, suggesting that newly-synthesized protein is involved in the increase in IFN-beta 2 transcription in response to IL-1 alpha but not in the response to the other stimuli.	Cycloheximide	127-140	interleukin 1 alpha	Homo sapiens	255-265
3258249-1	1988	In in vivo studies 0.5 U human interleukin 1 (IL-1) was inoculated daily into a subcutaneously implanted viscose cellulose sponge.	Cellulose	113-122	interleukin 1 alpha	Homo sapiens	31-50
3122755-0	1988	Comparative effects of interleukin 1 and a phorbol ester on rheumatoid synovial cell fructose 2,6-bisphosphate content and prostaglandin E production.	2,6-bisphosphate	94-110	interleukin 1 alpha	Homo sapiens	23-36
3122755-1	1988	The addition of either recombinant human interleukin 1 (IL1 alpha) or 12-O-tetradecanoyl phorbol-13-acetate (TPA) to cultured rheumatoid synovial cells (RSC) caused dose-related increases in PGE production and cellular fructose 2,6-bisphosphate (Fru-2,6-P2).	rsc	153-156	interleukin 1 alpha	Homo sapiens	41-65
3122755-1	1988	The addition of either recombinant human interleukin 1 (IL1 alpha) or 12-O-tetradecanoyl phorbol-13-acetate (TPA) to cultured rheumatoid synovial cells (RSC) caused dose-related increases in PGE production and cellular fructose 2,6-bisphosphate (Fru-2,6-P2).	Prostaglandins E	191-194	interleukin 1 alpha	Homo sapiens	41-65
3122755-1	1988	The addition of either recombinant human interleukin 1 (IL1 alpha) or 12-O-tetradecanoyl phorbol-13-acetate (TPA) to cultured rheumatoid synovial cells (RSC) caused dose-related increases in PGE production and cellular fructose 2,6-bisphosphate (Fru-2,6-P2).	fructose 2,6-diphosphate	219-244	interleukin 1 alpha	Homo sapiens	41-65
3122755-3	1988	A close association between increases in PGE production and Fru-2,6-P2 was demonstrated for both IL1- and TPA-stimulated cells.	Prostaglandins E	41-44	interleukin 1 alpha	Homo sapiens	97-100
3122755-5	1988	When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase.	Tetradecanoylphorbol Acetate	183-186	interleukin 1 alpha	Homo sapiens	5-8
3258335-5	1988	The 32P was incorporated into multiply cleaved precursors of IL-1 alpha, which appeared in the absence of protease inhibitors.	Phosphorus-32	4-7	interleukin 1 alpha	Homo sapiens	61-71
3258335-6	1988	Since the smallest Mr pre-IL-1 alpha that was labeled with 32P was 22 kDa, the phosphorylated serine residue is presumably located adjacent to a sequence of four basic amino acids located in the 4-kDa region at the amino terminus of the 22-kDa precursor of IL-1 alpha.	Phosphorus-32	59-62	interleukin 1 alpha	Homo sapiens	26-36
3258335-6	1988	Since the smallest Mr pre-IL-1 alpha that was labeled with 32P was 22 kDa, the phosphorylated serine residue is presumably located adjacent to a sequence of four basic amino acids located in the 4-kDa region at the amino terminus of the 22-kDa precursor of IL-1 alpha.	Serine	94-100	interleukin 1 alpha	Homo sapiens	26-36
3258335-6	1988	Since the smallest Mr pre-IL-1 alpha that was labeled with 32P was 22 kDa, the phosphorylated serine residue is presumably located adjacent to a sequence of four basic amino acids located in the 4-kDa region at the amino terminus of the 22-kDa precursor of IL-1 alpha.	Serine	94-100	interleukin 1 alpha	Homo sapiens	257-267
3073692-10	1988	IL-1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites.	Arachidonic Acid	72-88	interleukin 1 alpha	Homo sapiens	0-4
3363538-4	1988	The augmented response of IL-1 stimulated endothelial cells to these antagonists was actinomycin D sensitive.	Dactinomycin	85-98	interleukin 1 alpha	Homo sapiens	26-30
2854950-10	1988	Acetate stimulates the release of the inflammatory leukokine, interleukin-1 from human monocytes.	Acetates	0-7	interleukin 1 alpha	Homo sapiens	62-75
2854950-12	1988	Patients exposed to acetate containing hemodialysis fluids have 12-fold elevation in their plasma interleukin-1 levels.	Acetates	20-27	interleukin 1 alpha	Homo sapiens	98-111
2470287-0	1988	Human fibroblast and keratinocyte synthesis of eicosanoids in response to interleukin 1.	Eicosanoids	47-58	interleukin 1 alpha	Homo sapiens	74-87
2470302-0	1988	Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes.	Cycloheximide	36-49	interleukin 1 alpha	Homo sapiens	0-19
2470302-0	1988	Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes.	Dexamethasone	87-100	interleukin 1 alpha	Homo sapiens	0-19
2841909-1	1988	The purpose of this review is to underline the interactions between eicosanoids, platelet activating factor and IL-1.	Eicosanoids	68-79	interleukin 1 alpha	Homo sapiens	112-116
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Cycloheximide	159-172	interleukin 1 alpha	Homo sapiens	55-65
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Cycloheximide	159-172	interleukin 1 alpha	Homo sapiens	140-150
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	55-65
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	140-150
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tretinoin	183-196	interleukin 1 alpha	Homo sapiens	55-65
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tretinoin	183-196	interleukin 1 alpha	Homo sapiens	140-150
2470302-3	1988	RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.	Mifepristone	0-6	interleukin 1 alpha	Homo sapiens	111-121
2470302-3	1988	RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Homo sapiens	111-121
2470302-3	1988	RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.	Dexamethasone	130-143	interleukin 1 alpha	Homo sapiens	111-121
2470302-3	1988	RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.	Dexamethasone	183-196	interleukin 1 alpha	Homo sapiens	111-121
2841909-5	1988	Leukotriene products in addition to being pro-inflammatory per se also enhance IL-1 formation whilst cyclo-oxygenase products inhibit IL-1.	Leukotrienes	0-11	interleukin 1 alpha	Homo sapiens	79-83
3264514-12	1988	Purified human interleukin-1 (IL-1) given locally or systemically also produced bilateral hind paw hyperalgesia which was abolished by local administration of indomethacin.	Indomethacin	159-171	interleukin 1 alpha	Homo sapiens	15-34
3257870-2	1988	IL-1 also stimulated prostaglandin E2 and plasminogen activator synthesis, in parallel with PLA2 activation; all 3 were detectable within 6 hours of IL-1 treatment and peaked by 24 hours.	Dinoprostone	21-37	interleukin 1 alpha	Homo sapiens	0-4
3257870-2	1988	IL-1 also stimulated prostaglandin E2 and plasminogen activator synthesis, in parallel with PLA2 activation; all 3 were detectable within 6 hours of IL-1 treatment and peaked by 24 hours.	Dinoprostone	21-37	interleukin 1 alpha	Homo sapiens	149-153
3124931-3	1988	The neuronal responses to IL-1 were blocked or attenuated by concurrent application of mepacrine (a phospholipase inhibitor) or sodium salicylate (a cyclooxygenase inhibitor).	Quinacrine	87-96	interleukin 1 alpha	Homo sapiens	26-30
2840292-9	1988	These findings indicate that flavonoid-induced fever may be due to allergic as well as pseudo-allergic mechanisms, the latter probably caused by increased antigen-independent release of IL-1, the endogenous mediator of fever.	Flavonoids	29-38	interleukin 1 alpha	Homo sapiens	186-190
3124931-3	1988	The neuronal responses to IL-1 were blocked or attenuated by concurrent application of mepacrine (a phospholipase inhibitor) or sodium salicylate (a cyclooxygenase inhibitor).	Sodium Salicylate	128-145	interleukin 1 alpha	Homo sapiens	26-30
3124931-5	1988	The results are compatible with the view that one or more cyclooxygenase metabolites of arachidonic acid are involved in the IL-1 induced fever.	Arachidonic Acid	88-104	interleukin 1 alpha	Homo sapiens	125-129
3257189-4	1988	Contrary to our expectation, IL-1 markedly inhibited the LH-stimulated progesterone production in a dose-dependent manner.	Luteinizing Hormone	57-59	interleukin 1 alpha	Homo sapiens	29-33
3257189-4	1988	Contrary to our expectation, IL-1 markedly inhibited the LH-stimulated progesterone production in a dose-dependent manner.	Progesterone	71-83	interleukin 1 alpha	Homo sapiens	29-33
3257189-6	1988	In addition to effects on LH-induced differentiation, IL-1 exhibited an inhibitory effect on basal (unstimulated) progesterone production as well.	Progesterone	114-126	interleukin 1 alpha	Homo sapiens	54-58
3145923-0	1988	Restoration of anti-interleukin-1 depressed natural killer activity by human recombinant interferon alpha or gamma, human recombinant interleukin-2 and indomethacin.	Indomethacin	152-164	interleukin 1 alpha	Homo sapiens	20-33
3145923-4	1988	When the effector cells were pretreated with human recombinant interleukin-2, human interferon alpha or gamma and indomethacin alone or in combination, the inhibitory effect of antibody against human IL-1 was almost totally reversed.	Indomethacin	114-126	interleukin 1 alpha	Homo sapiens	200-204
3263331-3	1988	Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes.	Lithium	0-7	interleukin 1 alpha	Homo sapiens	35-48
3148560-0	1988	Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&amp;F 86002.	amicloral	74-80	interleukin 1 alpha	Homo sapiens	23-27
3148560-2	1988	SK&amp;F 86002, a novel dihydroimidazo thiazoline which inhibits both 5-lipoxygenase- and cyclooxygenase-mediated arachidonate metabolism was shown to be a potent inhibitor of IL-1 production by LPS-stimulated human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	176-180
3148560-2	1988	SK&amp;F 86002, a novel dihydroimidazo thiazoline which inhibits both 5-lipoxygenase- and cyclooxygenase-mediated arachidonate metabolism was shown to be a potent inhibitor of IL-1 production by LPS-stimulated human monocytes.	dihydroimidazo thiazoline	24-49	interleukin 1 alpha	Homo sapiens	176-180
3148560-7	1988	The inhibition of IL-1 production by SK&amp;F 86002 adds another facet of drug action contributing to its spectrum of anti-inflammatory activities.	amicloral	37-43	interleukin 1 alpha	Homo sapiens	18-22
3140130-1	1988	This study investigates the Il-1 production in vitro by normal peripheral blood monocytes or non-T cells following contact with different dialysis membranes (cuprophan, polysulphone, polymethylmethacrylate and polyacrylonitrile), in the presence or absence of lipopolysaccharide.	cuprammonium cellulose	158-167	interleukin 1 alpha	Homo sapiens	28-32
3278078-8	1988	To probe the mechanism of IL-1 action, cartilage samples were incubated with IL-1 in the presence of the protein synthesis inhibitor, cycloheximide, or the lysosomal membrane-stabilizing steroid, hydrocortisone.	Steroids	187-194	interleukin 1 alpha	Homo sapiens	26-30
3278078-9	1988	Cycloheximide at 5-10 micrograms/ml completely blocked IL-1-induced breakdown.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	55-59
3140130-1	1988	This study investigates the Il-1 production in vitro by normal peripheral blood monocytes or non-T cells following contact with different dialysis membranes (cuprophan, polysulphone, polymethylmethacrylate and polyacrylonitrile), in the presence or absence of lipopolysaccharide.	polysulfone P 1700	169-181	interleukin 1 alpha	Homo sapiens	28-32
3258249-1	1988	In in vivo studies 0.5 U human interleukin 1 (IL-1) was inoculated daily into a subcutaneously implanted viscose cellulose sponge.	viscose	105-112	interleukin 1 alpha	Homo sapiens	31-50
3140130-1	1988	This study investigates the Il-1 production in vitro by normal peripheral blood monocytes or non-T cells following contact with different dialysis membranes (cuprophan, polysulphone, polymethylmethacrylate and polyacrylonitrile), in the presence or absence of lipopolysaccharide.	Polymethyl Methacrylate	183-205	interleukin 1 alpha	Homo sapiens	28-32
3140130-1	1988	This study investigates the Il-1 production in vitro by normal peripheral blood monocytes or non-T cells following contact with different dialysis membranes (cuprophan, polysulphone, polymethylmethacrylate and polyacrylonitrile), in the presence or absence of lipopolysaccharide.	polyacrylonitrile	210-227	interleukin 1 alpha	Homo sapiens	28-32
3140130-3	1988	A modest Il-1 production, however, could be observed with synthetic membranes (polysulphone and polyacrylonitrile), but not with cellulose membranes (cuprophan).	polysulfone P 1700	79-91	interleukin 1 alpha	Homo sapiens	9-13
3140130-3	1988	A modest Il-1 production, however, could be observed with synthetic membranes (polysulphone and polyacrylonitrile), but not with cellulose membranes (cuprophan).	polyacrylonitrile	96-113	interleukin 1 alpha	Homo sapiens	9-13
3289031-0	1988	Glucoregulatory effects of interleukin-1: implications to the carbohydrate dyshomeostasis of septic shock.	Carbohydrates	62-74	interleukin 1 alpha	Homo sapiens	27-40
3075081-6	1988	Steroids also reduce the release or synthesis of plasminogen activator and certain cytokines such as interleukin 1 and macrophage migration inhibitory factor.	Steroids	0-8	interleukin 1 alpha	Homo sapiens	101-157
3131834-2	1988	Recombinant interleukin-1 induced an approximate 3-fold increase in [3H]-AA release, a 7-fold increase in PGE2 production and a 2-fold increase in PLA2 activity in human synovial fibroblasts.	Tritium	69-71	interleukin 1 alpha	Homo sapiens	12-25
3131834-2	1988	Recombinant interleukin-1 induced an approximate 3-fold increase in [3H]-AA release, a 7-fold increase in PGE2 production and a 2-fold increase in PLA2 activity in human synovial fibroblasts.	Dinoprostone	106-110	interleukin 1 alpha	Homo sapiens	12-25
3131834-6	1988	These data show that tumor necrosis factor and interleukin-1 can both activate synovial cell PLA2 and induce generation of PGE2, but act in an additive rather than a synergistic fashion.	Dinoprostone	123-127	interleukin 1 alpha	Homo sapiens	47-60
3266309-3	1988	During hemodialysis with four different membranes, plasma IL-1 activity rose with Cuprophan and Hemophan and was unchanged or reduced with Gambrane and Polysulfon.	cuprammonium cellulose	82-91	interleukin 1 alpha	Homo sapiens	58-62
3266309-3	1988	During hemodialysis with four different membranes, plasma IL-1 activity rose with Cuprophan and Hemophan and was unchanged or reduced with Gambrane and Polysulfon.	Hemophan	96-104	interleukin 1 alpha	Homo sapiens	58-62
3142038-0	1988	Effect of auranofin and sodium aurothiomalate on interleukin-1 production from human monocytes in vitro.	Auranofin	10-19	interleukin 1 alpha	Homo sapiens	49-62
3266309-3	1988	During hemodialysis with four different membranes, plasma IL-1 activity rose with Cuprophan and Hemophan and was unchanged or reduced with Gambrane and Polysulfon.	polycarbonate-polyether copolymer	139-147	interleukin 1 alpha	Homo sapiens	58-62
3266309-3	1988	During hemodialysis with four different membranes, plasma IL-1 activity rose with Cuprophan and Hemophan and was unchanged or reduced with Gambrane and Polysulfon.	polysulfon	152-162	interleukin 1 alpha	Homo sapiens	58-62
3266310-6	1988	In contrast, the IL-1 response to lipopolysaccharide was significantly decreased in PBMC from the patients compared to controls.	PBMC	84-88	interleukin 1 alpha	Homo sapiens	17-21
3142038-0	1988	Effect of auranofin and sodium aurothiomalate on interleukin-1 production from human monocytes in vitro.	Gold Sodium Thiomalate	24-45	interleukin 1 alpha	Homo sapiens	49-62
2826581-2	1987	Release of IL-1 activity by bacterial toxin-stimulated cells was completely blocked by 10 nM dexamethasone (Dex).	Dexamethasone	93-106	interleukin 1 alpha	Homo sapiens	11-15
2826581-2	1987	Release of IL-1 activity by bacterial toxin-stimulated cells was completely blocked by 10 nM dexamethasone (Dex).	Dexamethasone	108-111	interleukin 1 alpha	Homo sapiens	11-15
2826581-5	1987	Dex-mediated inhibition of IL-1 release appeared to be glucocorticoid receptor-mediated and was abrogated by progesterone.	Dexamethasone	0-3	interleukin 1 alpha	Homo sapiens	27-31
2826581-5	1987	Dex-mediated inhibition of IL-1 release appeared to be glucocorticoid receptor-mediated and was abrogated by progesterone.	Progesterone	109-121	interleukin 1 alpha	Homo sapiens	27-31
2826581-6	1987	In addition, Dex at high concentrations could inhibit post-transcriptional synthesis of IL-1 by prestimulated U937 cells.	Dexamethasone	13-16	interleukin 1 alpha	Homo sapiens	88-92
2826581-7	1987	Although Dex, 500 nM, did not change IL-1 mRNA levels in prestimulated cells, it completely blocked IL-1 release and induced a transient increase in cellular cyclic adenosine 3",5"-monophosphate (cAMP) levels.	Dexamethasone	9-12	interleukin 1 alpha	Homo sapiens	100-104
2826581-8	1987	Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis.	Dexamethasone	0-3	interleukin 1 alpha	Homo sapiens	27-31
2826581-8	1987	Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis.	Dexamethasone	0-3	interleukin 1 alpha	Homo sapiens	164-168
2826581-8	1987	Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis.	Cyclic AMP	106-110	interleukin 1 alpha	Homo sapiens	27-31
2826581-8	1987	Dex-mediated inhibition of IL-1 release in prestimulated cells is likely to occur via increased levels of cAMP, which have been shown to block post-transcriptional IL-1 synthesis.	Cyclic AMP	106-110	interleukin 1 alpha	Homo sapiens	164-168
2826581-9	1987	Our results indicate that glucocorticoids suppress IL-1 synthesis by two distinct mechanisms, blocking transcription of IL-1 mRNA during monocyte activation, and blocking post-transcriptional IL-1 synthesis via cAMP.	Cyclic AMP	211-215	interleukin 1 alpha	Homo sapiens	51-55
3322024-6	1987	Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane.	Prostaglandins	69-79	interleukin 1 alpha	Homo sapiens	31-35
2824488-3	1987	We report that interleukin-1 induces the stromelysin gene, and dexamethasone diminishes the level of induction by interleukin-1, epidermal growth factor, phorbol ester, and cAMP elevation (elicited by cholera toxin).	Dexamethasone	63-76	interleukin 1 alpha	Homo sapiens	114-127
3500170-1	1987	Interleukin 1 (IL-1), a monocyte product, exerts a range of biological effects on nonimmune cells such as fibroblasts and chondrocytes including stimulation of synthesis and release of prostaglandin E2 (PGE2) and collagenase.	Dinoprostone	185-201	interleukin 1 alpha	Homo sapiens	0-13
3500170-1	1987	Interleukin 1 (IL-1), a monocyte product, exerts a range of biological effects on nonimmune cells such as fibroblasts and chondrocytes including stimulation of synthesis and release of prostaglandin E2 (PGE2) and collagenase.	Dinoprostone	185-201	interleukin 1 alpha	Homo sapiens	15-19
3500170-1	1987	Interleukin 1 (IL-1), a monocyte product, exerts a range of biological effects on nonimmune cells such as fibroblasts and chondrocytes including stimulation of synthesis and release of prostaglandin E2 (PGE2) and collagenase.	Dinoprostone	203-207	interleukin 1 alpha	Homo sapiens	0-13
3500170-1	1987	Interleukin 1 (IL-1), a monocyte product, exerts a range of biological effects on nonimmune cells such as fibroblasts and chondrocytes including stimulation of synthesis and release of prostaglandin E2 (PGE2) and collagenase.	Dinoprostone	203-207	interleukin 1 alpha	Homo sapiens	15-19
3500170-2	1987	We have previously shown that crude mononuclear cell-conditioned medium, which contains IL-1, also stimulates synthesis of types I and III collagens by human synovial and dermal fibroblasts and chondrocytes when the formation of PGE2, which inhibits collagen synthesis, is blocked by indomethacin.	Dinoprostone	229-233	interleukin 1 alpha	Homo sapiens	88-92
3500170-2	1987	We have previously shown that crude mononuclear cell-conditioned medium, which contains IL-1, also stimulates synthesis of types I and III collagens by human synovial and dermal fibroblasts and chondrocytes when the formation of PGE2, which inhibits collagen synthesis, is blocked by indomethacin.	Indomethacin	284-296	interleukin 1 alpha	Homo sapiens	88-92
3500170-5	1987	In contrast, when endogenous IL-1-stimulated PGE2 synthesis was blocked by indomethacin, an enhancing effect of IL-1 on synthesis of these matrix proteins was unmasked.	Dinoprostone	45-49	interleukin 1 alpha	Homo sapiens	29-33
3266363-0	1988	Recombinant interleukin 1 and tumor necrosis factor acting in synergy to release thromboxane, 6-KETO-PGF1 alpha and PGE2 by human neutrophils.	Thromboxanes	81-92	interleukin 1 alpha	Homo sapiens	12-25
3266363-0	1988	Recombinant interleukin 1 and tumor necrosis factor acting in synergy to release thromboxane, 6-KETO-PGF1 alpha and PGE2 by human neutrophils.	6-Ketoprostaglandin F1 alpha	94-111	interleukin 1 alpha	Homo sapiens	12-25
3266363-0	1988	Recombinant interleukin 1 and tumor necrosis factor acting in synergy to release thromboxane, 6-KETO-PGF1 alpha and PGE2 by human neutrophils.	Dinoprostone	116-120	interleukin 1 alpha	Homo sapiens	12-25
3266363-2	1988	In this study, we examined the ability of human polymorphonuclears (PMN) to synthesize TRxA2, 6-KETO-PGF1 alpha and PGE2 in response to human recombinant interleukin 1 (IL1) and tumor necrosis factor (TNF) alone and in combination.	6-Ketoprostaglandin F1 alpha	94-111	interleukin 1 alpha	Homo sapiens	154-167
3266363-2	1988	In this study, we examined the ability of human polymorphonuclears (PMN) to synthesize TRxA2, 6-KETO-PGF1 alpha and PGE2 in response to human recombinant interleukin 1 (IL1) and tumor necrosis factor (TNF) alone and in combination.	6-Ketoprostaglandin F1 alpha	94-111	interleukin 1 alpha	Homo sapiens	169-172
3266363-2	1988	In this study, we examined the ability of human polymorphonuclears (PMN) to synthesize TRxA2, 6-KETO-PGF1 alpha and PGE2 in response to human recombinant interleukin 1 (IL1) and tumor necrosis factor (TNF) alone and in combination.	Dinoprostone	116-120	interleukin 1 alpha	Homo sapiens	154-167
3322024-6	1987	Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane.	Prostaglandins	80-93	interleukin 1 alpha	Homo sapiens	31-35
3322024-6	1987	Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane.	Prostaglandins	95-97	interleukin 1 alpha	Homo sapiens	31-35
3322024-6	1987	Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane.	Prostaglandins E	207-222	interleukin 1 alpha	Homo sapiens	31-35
3322024-6	1987	Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane.	Prostaglandins E	207-222	interleukin 1 alpha	Homo sapiens	182-186
3322024-7	1987	The results indicated that cycling MCs release primarily PGE in response to purified IL-1.	Prostaglandins E	57-60	interleukin 1 alpha	Homo sapiens	85-89
2961462-0	1987	The activation of human fibroblast prostaglandin E production by interleukin 1.	Prostaglandins E	35-50	interleukin 1 alpha	Homo sapiens	65-78
3322024-8	1987	The local release by either monocytes or mesangial cells of IL-1 during glomerular inflammation, with subsequent mesangial cell generation of vasodilatory PGE, may be responsible in part for the alterations in the glomerular microcirculation observed in these disorders.	Prostaglandins E	155-158	interleukin 1 alpha	Homo sapiens	60-64
3501247-6	1987	Both recombinant interleukin 1 and tumor necrosis factor-alpha stimulated the production of prostaglandin E2 (PGE2).	Dinoprostone	92-108	interleukin 1 alpha	Homo sapiens	17-62
3501247-6	1987	Both recombinant interleukin 1 and tumor necrosis factor-alpha stimulated the production of prostaglandin E2 (PGE2).	Dinoprostone	110-114	interleukin 1 alpha	Homo sapiens	17-62
3501247-8	1987	This study demonstrates that although interleukin 1 and tumor necrosis factor-alpha induce a PGE2 response by skeletal muscle in vitro, some macrophage product distinct from either interleukin 1 or tumor necrosis factor-alpha is responsible for the accelerated skeletal protein degradation seen with partially purified human blood monocyte products.	Dinoprostone	93-97	interleukin 1 alpha	Homo sapiens	38-83
2961462-1	1987	We have examined the induction of prostaglandin E2 (PGE2) release from fibroblasts by human interleukin 1 (IL-1).	Dinoprostone	34-50	interleukin 1 alpha	Homo sapiens	92-111
2961462-1	1987	We have examined the induction of prostaglandin E2 (PGE2) release from fibroblasts by human interleukin 1 (IL-1).	Dinoprostone	52-56	interleukin 1 alpha	Homo sapiens	92-111
2961462-5	1987	IL-1 appears to directly induce the increase in PGE2 since removal of other proteins from culture medium does not affect induction.	Dinoprostone	48-52	interleukin 1 alpha	Homo sapiens	0-4
2961462-6	1987	PGE2 induction by IL-1 also does not require cell proliferation.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	18-22
2961462-9	1987	However, the ability to convert arachidonic acid to PGE2 is increased following 5 hr of culture with IL-1.	Arachidonic Acid	32-48	interleukin 1 alpha	Homo sapiens	101-105
2961462-9	1987	However, the ability to convert arachidonic acid to PGE2 is increased following 5 hr of culture with IL-1.	Dinoprostone	52-56	interleukin 1 alpha	Homo sapiens	101-105
2961462-11	1987	Taken together these results suggest that IL-1 induction of fibroblast PGE2 involves the synthesis of new protein or proteins involved in the conversion of free arachidonic acid to PGE2.	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	42-46
2961462-11	1987	Taken together these results suggest that IL-1 induction of fibroblast PGE2 involves the synthesis of new protein or proteins involved in the conversion of free arachidonic acid to PGE2.	Arachidonic Acid	161-177	interleukin 1 alpha	Homo sapiens	42-46
2961462-11	1987	Taken together these results suggest that IL-1 induction of fibroblast PGE2 involves the synthesis of new protein or proteins involved in the conversion of free arachidonic acid to PGE2.	Dinoprostone	181-185	interleukin 1 alpha	Homo sapiens	42-46
3119264-6	1987	Adsorption of SLE ACS with Sepharose-bound antiserum against IL-1 prevented ACS-induced increases in IgG synthesis.	Sepharose	27-36	interleukin 1 alpha	Homo sapiens	61-65
3501398-0	1987	Antibodies to interleukin-1 raised with synthetic peptides: identification of external sites and analysis of interleukin-1 synthesis in stimulated human peripheral blood monocytes.	Peptides	50-58	interleukin 1 alpha	Homo sapiens	14-27
3121313-6	1987	Cycloheximide even superinduces this gene when added together with poly(rI).poly(rC) and interleukin-1 (but not when added with interferon).	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	89-102
3127333-4	1987	IL-1 also induces histamine release and granule release from basophils, eosinophils and neutrophils.	Histamine	18-27	interleukin 1 alpha	Homo sapiens	0-4
3500253-2	1987	IL-1a alone stimulated neutrophil hydrogen peroxide production in a dose-dependent manner, but the rate was much lower than that of opsonized zymosan.	Hydrogen Peroxide	34-51	interleukin 1 alpha	Homo sapiens	0-5
3500170-5	1987	In contrast, when endogenous IL-1-stimulated PGE2 synthesis was blocked by indomethacin, an enhancing effect of IL-1 on synthesis of these matrix proteins was unmasked.	Indomethacin	75-87	interleukin 1 alpha	Homo sapiens	29-33
3500170-7	1987	In human foreskin fibroblasts, which produced low levels of PGE2 even in the presence of IL-1, synthesis of types I and III collagens was increased by IL-1 either in the absence or presence of indomethacin.	Dinoprostone	60-64	interleukin 1 alpha	Homo sapiens	151-155
3500955-0	1987	Recombinant human interleukin-1 inhibits the induction by dexamethasone of alkaline phosphatase activity in murine capillary endothelial cells.	Dexamethasone	58-71	interleukin 1 alpha	Homo sapiens	18-31
3500955-3	1987	Dexamethasone increases the specific activity of alkaline phosphatase in a time- and dose-dependent fashion (maximum 14-fold induction at 10(-6) M, IC50 = 10(-8) M), and this induction can be completely inhibited by simultaneous incubation with picomolar concentrations of recombinant human IL-1 alpha or IL-1 beta.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	291-301
3500253-6	1987	Pretreatment of the neutrophils with IL-1a augmented neutrophil oxygen radical production induced by opsonized zymosan, and this synergistic effect was evident as early as 10 min after IL-1a was added to the neutrophil culture.	Reactive Oxygen Species	64-78	interleukin 1 alpha	Homo sapiens	37-42
3500253-6	1987	Pretreatment of the neutrophils with IL-1a augmented neutrophil oxygen radical production induced by opsonized zymosan, and this synergistic effect was evident as early as 10 min after IL-1a was added to the neutrophil culture.	Zymosan	111-118	interleukin 1 alpha	Homo sapiens	37-42
3500253-6	1987	Pretreatment of the neutrophils with IL-1a augmented neutrophil oxygen radical production induced by opsonized zymosan, and this synergistic effect was evident as early as 10 min after IL-1a was added to the neutrophil culture.	Zymosan	111-118	interleukin 1 alpha	Homo sapiens	185-190
3500253-7	1987	Phagocytosis of opsonized particles by neutrophils, and degranulation induced by opsonized zymosan were also enhanced by IL-1a in a dose-dependent manner.	Zymosan	91-98	interleukin 1 alpha	Homo sapiens	121-126
3500254-4	1987	In vitro studies of the direct effects of CY metabolites (mafosfamide and 4-hydroperoxycyclophosphamide) on human monocytes showed only concomitant decreases in production of IL-1 and TNF-like molecules.	Cyclophosphamide	42-44	interleukin 1 alpha	Homo sapiens	175-179
3500254-4	1987	In vitro studies of the direct effects of CY metabolites (mafosfamide and 4-hydroperoxycyclophosphamide) on human monocytes showed only concomitant decreases in production of IL-1 and TNF-like molecules.	mafosfamide	58-69	interleukin 1 alpha	Homo sapiens	175-179
3125316-1	1987	We studied the effects in vitro of sodium aurothiomalate (GSTM) on the production of, and response to, a monocyte supernatant with interleukin-1 (IL-1)-like activity.	Gold Sodium Thiomalate	35-56	interleukin 1 alpha	Homo sapiens	131-144
3125316-1	1987	We studied the effects in vitro of sodium aurothiomalate (GSTM) on the production of, and response to, a monocyte supernatant with interleukin-1 (IL-1)-like activity.	Gold Sodium Thiomalate	35-56	interleukin 1 alpha	Homo sapiens	146-150
3125316-2	1987	Monocyte supernatant was produced by human peripheral blood monocytes stimulated with lipoprotein polysaccharide, and its IL-1-like activity assayed by its effect on tritiated thymidine incorporation by C3H/HeJ mouse thymocytes.	Thymidine	176-185	interleukin 1 alpha	Homo sapiens	122-126
3325909-3	1987	Using 100 micrograms/ml, extracellular IL-1 activity was found to be decreased by quinolones (about 35% of the control without antibiotic) without modification of the cell-associated IL-1 activity.	Quinolones	82-92	interleukin 1 alpha	Homo sapiens	39-43
3325909-4	1987	Extra and intracellular IL-1 was only slightly decreased by cephalosporins, while penicillin did not alter the IL-1 activities.	Cephalosporins	60-74	interleukin 1 alpha	Homo sapiens	24-28
3325909-5	1987	Spiramycin and doxycycline using 100 micrograms/ml increased extracellular IL-1 while cell-associated was decreased.	Spiramycin	0-10	interleukin 1 alpha	Homo sapiens	75-79
3325909-5	1987	Spiramycin and doxycycline using 100 micrograms/ml increased extracellular IL-1 while cell-associated was decreased.	Doxycycline	15-26	interleukin 1 alpha	Homo sapiens	75-79
2890857-5	1987	In contrast, in febrile patients" serum and urine IL-1 activity was low, apparently reflecting the presence of a strong inhibitor of IL-1 activity measured by the inhibition of prostaglandin E2 production by synovial cells.	Dinoprostone	177-193	interleukin 1 alpha	Homo sapiens	50-54
2890857-5	1987	In contrast, in febrile patients" serum and urine IL-1 activity was low, apparently reflecting the presence of a strong inhibitor of IL-1 activity measured by the inhibition of prostaglandin E2 production by synovial cells.	Dinoprostone	177-193	interleukin 1 alpha	Homo sapiens	133-137
2825706-3	1987	Although extracellular calcium (Ca2+) enhances but is not required for the expression of granule exocytosis, IL-1 did induce the mobilization of previously sequestered intracellular Ca2+ as measured with the highly selective fluorescent Ca2+ indicator, Quin 2.	Quin2	253-259	interleukin 1 alpha	Homo sapiens	109-113
2825706-4	1987	Further, IL-1 stimulated the mobilization of cell membrane-associated Ca2+ as monitored by a decrease in fluorescence of chlorotetracycline (CTC)-loaded neutrophils.	Chlortetracycline	121-139	interleukin 1 alpha	Homo sapiens	9-13
2825706-5	1987	W-7, a calmodulin antagonist, and TMB-8[8(N,N-diethylamino)-octyl-(3,4,5-trimethoxy)benzoate hydrochloride], an intracellular Ca2+ antagonist, inhibited the Quin 2 fluorescent response by neutrophils to IL-1.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	40-106	interleukin 1 alpha	Homo sapiens	203-207
2825706-6	1987	TPCK (N-alpha-p-tosyl-L-lysine chloromethylketone), a serine protease inhibitor, suppressed IL-1-induced Quin 2 and CTC fluorescence.	n-alpha-p-tosyl-l-lysine chloromethylketone	6-49	interleukin 1 alpha	Homo sapiens	92-96
2825706-7	1987	Exposure of neutrophils to IL-1 resulted in a concentration-dependent production of the 5-lipoxygenase product, LTB4 [5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid] which was enhanced in the presence of arachidonic acid (AA).	5(s),12(r)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid	118-180	interleukin 1 alpha	Homo sapiens	27-31
2825706-7	1987	Exposure of neutrophils to IL-1 resulted in a concentration-dependent production of the 5-lipoxygenase product, LTB4 [5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid] which was enhanced in the presence of arachidonic acid (AA).	Arachidonic Acid	220-236	interleukin 1 alpha	Homo sapiens	27-31
3502394-0	1987	Prostaglandin formation in feline cerebral microvessels: effect of endotoxin and interleukin-1.	Prostaglandins	0-13	interleukin 1 alpha	Homo sapiens	81-94
2890635-8	1987	The induction of SAA is pretranslational and is likely to be mediated by protein factor(s) since incubation with cycloheximide diminished IL-1-dependent increase in SAA mRNA.	Cycloheximide	113-126	interleukin 1 alpha	Homo sapiens	138-142
2960734-3	1987	Extraction of 125I-labeled IL-1 alpha cross-linked to IL-1 receptor on steroid-treated PBMC yielded two bands estimated to be 60 and 70 kDa in molecular mass.	Iodine-125	14-18	interleukin 1 alpha	Homo sapiens	27-37
2960734-3	1987	Extraction of 125I-labeled IL-1 alpha cross-linked to IL-1 receptor on steroid-treated PBMC yielded two bands estimated to be 60 and 70 kDa in molecular mass.	Iodine-125	14-18	interleukin 1 alpha	Homo sapiens	27-31
2960734-3	1987	Extraction of 125I-labeled IL-1 alpha cross-linked to IL-1 receptor on steroid-treated PBMC yielded two bands estimated to be 60 and 70 kDa in molecular mass.	Steroids	71-78	interleukin 1 alpha	Homo sapiens	27-37
2960734-3	1987	Extraction of 125I-labeled IL-1 alpha cross-linked to IL-1 receptor on steroid-treated PBMC yielded two bands estimated to be 60 and 70 kDa in molecular mass.	Steroids	71-78	interleukin 1 alpha	Homo sapiens	27-31
2960734-5	1987	Carrier-free recombinant human IL-1 alpha induced phosphorylation of an acidic 65-kDa protein (pp65) at serine residues within 5 min more effectively in glucocorticoid-treated PBMC than in untreated PBMC.	Serine	104-110	interleukin 1 alpha	Homo sapiens	31-41
2960734-6	1987	Fractionation of extracts of IL-1-stimulated prednisolone-pretreated PBMC by ultracentrifugation showed that pp65 is located in the cytosol, suggesting that pp65 is not the IL-1 receptor itself.	Prednisolone	45-57	interleukin 1 alpha	Homo sapiens	29-33
2959567-4	1987	By site specific mutagenesis, we have shown that the arginine at the fourth position of IL-1 is one of the key residues in the function of IL-1.	Arginine	53-61	interleukin 1 alpha	Homo sapiens	88-92
2959567-4	1987	By site specific mutagenesis, we have shown that the arginine at the fourth position of IL-1 is one of the key residues in the function of IL-1.	Arginine	53-61	interleukin 1 alpha	Homo sapiens	139-143
3127333-5	1987	IL-1 dramatically increases arachidonic acid metabolites in a variety of cells; increased PGE2 synthesis accounts for its inflammatory properties.	Arachidonic Acid	28-44	interleukin 1 alpha	Homo sapiens	0-4
3499215-3	1987	Purified IL-1 (0.5 to 8 units/ml) was added to SW-13 cells cultured in soft agar.	Agar	76-80	interleukin 1 alpha	Homo sapiens	9-13
3499215-7	1987	This antibody did, however, completely inhibit the ability of purified IL-1 to support the growth of SW-13 colonies in soft agar.	Agar	124-128	interleukin 1 alpha	Homo sapiens	71-75
3499215-8	1987	IL-1 increased growth of quiescent SW-13 cells cultured in monolayers as assessed by tritiated thymidine incorporation assays.	Thymidine	95-104	interleukin 1 alpha	Homo sapiens	0-4
3502394-11	1987	We conclude that the cerebral microvasculature does not lend itself to an active role in the genesis of fever by being the site at which blood-borne interleukin-1 promotes prostaglandin E2 synthesis.	Dinoprostone	172-188	interleukin 1 alpha	Homo sapiens	149-162
3499376-5	1987	The stimulatory effects of the chemotactic peptide FMLP and the phorbol ester PMA were ameliorated by IL-1 but augmented by TNF alpha.	phorbol ester pma	64-81	interleukin 1 alpha	Homo sapiens	102-106
3315937-0	1987	Interleukin 1: regulation of hepatic carbohydrate metabolism by insulin or insulinomimesis.	hepatic carbohydrate	29-49	interleukin 1 alpha	Homo sapiens	0-13
3501397-3	1987	The results showed that strong first stage and second stage tumor promoters such as TPA, PDBu, PRA, MEZ and APL are also strong stimulators of IL 1 and H2O2 generation, whereas weak tumor promoters exhibited a low, if any, effect at all.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Homo sapiens	143-156
3502166-0	1987	Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2.	ether lipids	24-36	interleukin 1 alpha	Homo sapiens	70-83
2443979-1	1987	Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH).	Corticosterone	110-124	interleukin 1 alpha	Homo sapiens	52-65
2443979-1	1987	Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH).	Corticosterone	110-124	interleukin 1 alpha	Homo sapiens	67-71
3116843-7	1987	We speculate that therapy with CyA and prednisone inhibited the production of interleukins-1 and -2 from monocytes and T-cells, respectively, and was responsible for the reduction of the T gamma cell fraction and B-cell leukemic mass in this patient.	Cyclosporine	31-34	interleukin 1 alpha	Homo sapiens	78-99
3116090-3	1987	In these studies, we have examined the ability of C5a and C5a des Arg to induce IL-1 production in vitro.	Arginine	66-69	interleukin 1 alpha	Homo sapiens	80-84
3116090-4	1987	Human C5a and C5a des Arg were purified to homogeneity and were found to stimulate IL-1 release from freshly obtained human mononuclear cells into the extracellular medium.	Arginine	22-25	interleukin 1 alpha	Homo sapiens	83-87
3116090-6	1987	The minimal concentration of C5a required was 25 ng/ml, whereas 125 ng/ml of C5a des Arg induced comparable amounts of IL-1.	Arginine	85-88	interleukin 1 alpha	Homo sapiens	119-123
3116843-7	1987	We speculate that therapy with CyA and prednisone inhibited the production of interleukins-1 and -2 from monocytes and T-cells, respectively, and was responsible for the reduction of the T gamma cell fraction and B-cell leukemic mass in this patient.	Prednisone	39-49	interleukin 1 alpha	Homo sapiens	78-99
2961488-8	1987	Pretreatment of ADH with 5 mJ/cm2 UV-B decreased lipopolysaccharide-stimulated IL-1 activity from 169 +/- 34 (mean U/ml +/- s.e.)	adh	16-19	interleukin 1 alpha	Homo sapiens	79-83
2961488-12	1987	Addition of IL-1 partially restored accessory activity of UV-B irradiated ADH for lymphocyte responses to TT.	adh	74-77	interleukin 1 alpha	Homo sapiens	12-16
2961488-14	1987	Thus, low doses of UV-B are deleterious to accessory function and to production of IL-1 by ADH.	adh	91-94	interleukin 1 alpha	Homo sapiens	83-87
3308437-5	1987	IL-1 was found to reduce insulin release in culture and totally inhibit glucose-stimulated insulin release in short-term incubations.	Glucose	72-79	interleukin 1 alpha	Homo sapiens	0-4
3500810-5	1987	In addition, when culture supernatants of thyrocytes stimulated with lentinan or monocyte-derived interleukin 1 (IL-1) were incubated with a rabbit antibody to human IL-1, a parallel reduction in TSA was observed, suggesting that the active product in the thyrocyte culture supernatant shared a common antigenic site with IL-1.	trichostatin A	196-199	interleukin 1 alpha	Homo sapiens	98-111
3500810-5	1987	In addition, when culture supernatants of thyrocytes stimulated with lentinan or monocyte-derived interleukin 1 (IL-1) were incubated with a rabbit antibody to human IL-1, a parallel reduction in TSA was observed, suggesting that the active product in the thyrocyte culture supernatant shared a common antigenic site with IL-1.	trichostatin A	196-199	interleukin 1 alpha	Homo sapiens	113-117
3500810-5	1987	In addition, when culture supernatants of thyrocytes stimulated with lentinan or monocyte-derived interleukin 1 (IL-1) were incubated with a rabbit antibody to human IL-1, a parallel reduction in TSA was observed, suggesting that the active product in the thyrocyte culture supernatant shared a common antigenic site with IL-1.	trichostatin A	196-199	interleukin 1 alpha	Homo sapiens	166-170
3500810-5	1987	In addition, when culture supernatants of thyrocytes stimulated with lentinan or monocyte-derived interleukin 1 (IL-1) were incubated with a rabbit antibody to human IL-1, a parallel reduction in TSA was observed, suggesting that the active product in the thyrocyte culture supernatant shared a common antigenic site with IL-1.	trichostatin A	196-199	interleukin 1 alpha	Homo sapiens	166-170
3119348-9	1987	However, excess quantities of exogenous IL 2, especially when added in conjunction with IL 1, were able to partially overcome the ability of SER to inhibit T cell proliferation.	Serine	141-144	interleukin 1 alpha	Homo sapiens	88-92
3308437-6	1987	Islet (pro)insulin biosynthesis, glucose oxidation, and oxygen uptake at 16.7 mM glucose were partially inhibited by IL-1.	Oxygen	56-62	interleukin 1 alpha	Homo sapiens	117-121
3308437-6	1987	Islet (pro)insulin biosynthesis, glucose oxidation, and oxygen uptake at 16.7 mM glucose were partially inhibited by IL-1.	Glucose	33-40	interleukin 1 alpha	Homo sapiens	117-121
2821111-7	1987	Because interleukin 1 (IL-1) is a cytocidal factor produced by activated monocytes, we also investigated the effect of CKS-17 on IL-1 production by monocytes and on direct IL-1-mediated cytotoxicity.	CKS 17	119-125	interleukin 1 alpha	Homo sapiens	129-133
3498642-4	1987	We demonstrate here that recombinant human IL-1 alpha and beta stimulate the dose-dependent release of granulocyte-macrophage colony-stimulating activity (GM-CSA) and burst-promoting activity (BPA) by cultured human bone marrow fibroblasts.	gm-csa	155-161	interleukin 1 alpha	Homo sapiens	43-53
2821111-7	1987	Because interleukin 1 (IL-1) is a cytocidal factor produced by activated monocytes, we also investigated the effect of CKS-17 on IL-1 production by monocytes and on direct IL-1-mediated cytotoxicity.	CKS 17	119-125	interleukin 1 alpha	Homo sapiens	129-133
2821111-12	1987	These data suggest that CKS-17 may be a potent inhibitor of IL-1.	CKS 17	24-30	interleukin 1 alpha	Homo sapiens	60-64
3498758-9	1987	Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release.	Dexamethasone	82-85	interleukin 1 alpha	Homo sapiens	146-150
3498758-9	1987	Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release.	Dexamethasone	82-85	interleukin 1 alpha	Homo sapiens	288-292
3498758-9	1987	Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release.	Hydrocortisone	90-104	interleukin 1 alpha	Homo sapiens	146-150
3498758-9	1987	Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release.	Hydrocortisone	90-104	interleukin 1 alpha	Homo sapiens	288-292
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Betamethasone	173-187	interleukin 1 alpha	Homo sapiens	14-18
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Triamcinolone Acetonide	202-225	interleukin 1 alpha	Homo sapiens	14-18
3323504-1	1987	Treatment of rabbit articular chondrocytes with 0.5-5 units/ml of recombinant human interleukin-1 (IL-1) induced phospholipase A2 (PLA2) activation, prostaglandin E2 (PGE2) biosynthesis and latent neutral protease secretion by these cells.	Dinoprostone	149-165	interleukin 1 alpha	Homo sapiens	84-97
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Dexamethasone	239-242	interleukin 1 alpha	Homo sapiens	14-18
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Fludrocortisone	256-271	interleukin 1 alpha	Homo sapiens	14-18
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Prednisolone	285-297	interleukin 1 alpha	Homo sapiens	14-18
3498758-11	1987	Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone).	Hydrocortisone	311-325	interleukin 1 alpha	Homo sapiens	14-18
3323504-1	1987	Treatment of rabbit articular chondrocytes with 0.5-5 units/ml of recombinant human interleukin-1 (IL-1) induced phospholipase A2 (PLA2) activation, prostaglandin E2 (PGE2) biosynthesis and latent neutral protease secretion by these cells.	Dinoprostone	149-165	interleukin 1 alpha	Homo sapiens	99-103
3323504-1	1987	Treatment of rabbit articular chondrocytes with 0.5-5 units/ml of recombinant human interleukin-1 (IL-1) induced phospholipase A2 (PLA2) activation, prostaglandin E2 (PGE2) biosynthesis and latent neutral protease secretion by these cells.	Dinoprostone	167-171	interleukin 1 alpha	Homo sapiens	84-97
3323504-1	1987	Treatment of rabbit articular chondrocytes with 0.5-5 units/ml of recombinant human interleukin-1 (IL-1) induced phospholipase A2 (PLA2) activation, prostaglandin E2 (PGE2) biosynthesis and latent neutral protease secretion by these cells.	Dinoprostone	167-171	interleukin 1 alpha	Homo sapiens	99-103
3323504-5	1987	These results provide unequivocal evidence that IL-1 is a potent activator of chondrocyte arachidonate metabolism and hydrolytic protease secretion.	chondrocyte arachidonate	78-102	interleukin 1 alpha	Homo sapiens	48-52
2828770-3	1987	Antigen-reactive B cells mount a strong immune response in the presence of IL-1 and IL-2 when their cAMP is high, but become unresponsive when their cAMP is low.	Cyclic AMP	100-104	interleukin 1 alpha	Homo sapiens	75-79
3501505-6	1987	Inducers of IL-1 are present in dialysate and induce bacterial pyrogen and acetate.	Acetates	75-82	interleukin 1 alpha	Homo sapiens	12-16
3501505-8	1987	Muramyl dipeptides have been found in CAPD drain fluid and are more potent inducers of IL-1 than endotoxin.	Dipeptides	8-18	interleukin 1 alpha	Homo sapiens	87-91
2828770-4	1987	We show here that reagents which raise cAMP concentrations (Prostaglandin E, cholera toxin, forskolin) synergize strongly with IL-1 and IL-2 in the generation of antibody.	Cyclic AMP	39-43	interleukin 1 alpha	Homo sapiens	127-131
2828770-4	1987	We show here that reagents which raise cAMP concentrations (Prostaglandin E, cholera toxin, forskolin) synergize strongly with IL-1 and IL-2 in the generation of antibody.	Prostaglandins E	60-75	interleukin 1 alpha	Homo sapiens	127-131
3499607-3	1987	When bone marrow cells from 5-fluorouracil-treated mice were cultured in suspension for 7 days with recombinant human IL-1 alpha and/or G-CSF, it was found that the two factors synergized to enhance recovery of myelopoietic cells and colony-forming cells of both high and low proliferative potential.	Fluorouracil	28-42	interleukin 1 alpha	Homo sapiens	118-128
3499607-6	1987	Daily administration of recombinant human G-CSF or recombinant human IL-1 alpha accelerated recovery of stem cells, progenitor cells, and blood neutrophils by up to 4 days in 5-fluorouracil-treated C3H/HeJ and B6D2F1 mice.	Fluorouracil	175-189	interleukin 1 alpha	Homo sapiens	69-79
3509874-1	1987	Recombinant-derived human interleukin-1 alpha (IL-1 alpha), purified from Escherichia coli, was resolved by isoelectric focusing on polyacrylamide gels into two species of isoelectric points (pI) 5.45 and 5.20, which constituted approximately 75% and approximately 25% of the total IL-1 alpha protein respectively.	polyacrylamide	132-146	interleukin 1 alpha	Homo sapiens	26-45
3509874-1	1987	Recombinant-derived human interleukin-1 alpha (IL-1 alpha), purified from Escherichia coli, was resolved by isoelectric focusing on polyacrylamide gels into two species of isoelectric points (pI) 5.45 and 5.20, which constituted approximately 75% and approximately 25% of the total IL-1 alpha protein respectively.	polyacrylamide	132-146	interleukin 1 alpha	Homo sapiens	47-57
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Asparagine	193-196	interleukin 1 alpha	Homo sapiens	60-70
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Asparagine	193-196	interleukin 1 alpha	Homo sapiens	177-187
2444222-1	1987	This study examines the potential role of calcium in the activation of human monocytes by bacterial lipopolysaccharide (LPS) to produce interleukin-1 (IL-1).	Calcium	42-49	interleukin 1 alpha	Homo sapiens	136-149
2444222-1	1987	This study examines the potential role of calcium in the activation of human monocytes by bacterial lipopolysaccharide (LPS) to produce interleukin-1 (IL-1).	Calcium	42-49	interleukin 1 alpha	Homo sapiens	151-155
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Aspartic Acid	198-201	interleukin 1 alpha	Homo sapiens	60-70
2444222-3	1987	Triggering of IL-1 production by LPS cannot be blocked by depletion of extracellular calcium, blockade of calcium channels, or addition of agents which antagonize the effects of intracellular calcium.	Calcium	85-92	interleukin 1 alpha	Homo sapiens	14-18
2444222-3	1987	Triggering of IL-1 production by LPS cannot be blocked by depletion of extracellular calcium, blockade of calcium channels, or addition of agents which antagonize the effects of intracellular calcium.	Calcium	106-113	interleukin 1 alpha	Homo sapiens	14-18
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Aspartic Acid	198-201	interleukin 1 alpha	Homo sapiens	177-187
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Serine	205-208	interleukin 1 alpha	Homo sapiens	60-70
3509874-6	1987	and circular dichroism analyses of wild-type and the mutant IL-1 alpha indicated a similar conformation which was also indicated by the identical receptor binding affinities of IL-1 alpha with Asn, Asp or Ser in position 36.	Serine	205-208	interleukin 1 alpha	Homo sapiens	177-187
3497982-14	1987	At concentrations of 100 ng/ml, IL-1-alpha induced prostaglandin E2 production in the MNC culture, and this was associated with decreased production of immunoreactive IL-1-beta.	Dinoprostone	51-67	interleukin 1 alpha	Homo sapiens	32-42
3497982-15	1987	Adding indomethacin to the cultures prevented the decreased production of IL-1-beta induced by high concentrations of IL-1-alpha.	Indomethacin	7-19	interleukin 1 alpha	Homo sapiens	118-128
3497983-5	1987	rIL-1 induced IL-1-alpha mRNA only in EC treated concomitantly with cycloheximide (2 micrograms/ml).	Cycloheximide	68-81	interleukin 1 alpha	Homo sapiens	14-24
3502083-5	1987	Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production.	Tetradecanoylphorbol Acetate	12-37	interleukin 1 alpha	Homo sapiens	102-106
3498485-2	1987	Concomitantly, IL-1 stimulated the prostaglandin E2 synthesis and nitroblue tetrazolium dye-reducing capacity of JOSK-I cells.	Dinoprostone	35-51	interleukin 1 alpha	Homo sapiens	15-19
3117462-8	1987	Addition of in vitro purified IL-1 to nonadherent cells enhanced 1,25-dihydroxyvitamin D3-induced inhibition of Ig production.	Calcitriol	65-89	interleukin 1 alpha	Homo sapiens	30-34
3317752-3	1987	This inhibitor from febrile individuals also blocks antigen-induced activation of human peripheral blood lymphocytes in vitro but increases, rather than decreases IL-1-induced production of prostaglandin E2 by fibroblasts.	Dinoprostone	190-206	interleukin 1 alpha	Homo sapiens	163-167
3317752-7	1987	Unlike the febrile inhibitor and uromodulin, this 25-kdal molecule has been found to be a potent inhibitor of IL-1-induced production of prostaglandin E2 by fibroblasts as well as of the proliferation of thymocytes.	Dinoprostone	137-153	interleukin 1 alpha	Homo sapiens	110-114
3498485-2	1987	Concomitantly, IL-1 stimulated the prostaglandin E2 synthesis and nitroblue tetrazolium dye-reducing capacity of JOSK-I cells.	Nitroblue Tetrazolium	66-87	interleukin 1 alpha	Homo sapiens	15-19
3500594-5	1987	Of the disease modifying agents tested, levamisole was ineffective while the antimalarials, chloroquine (100 microM) and hydroxychloroquine (100 microM), inhibited the action of IL-1.	Levamisole	40-50	interleukin 1 alpha	Homo sapiens	178-182
3112227-3	1987	The findings that i) PFA-fixed Mo did not produce or release IL 1, ii) the accessory function of PFA-fixed Mo could be inhibited with pretreatment with anti-IL 1 antibody, iii) PFA-fixed Mo had a comitogenic effect in the murine thymocyte assay, and iv) there was a temporal difference between the capacities to function in the comitogenic assay and to produce soluble IL 1, suggest that human Mo can express membrane-associated IL 1 and that it is functionally relevant.	paraform	97-100	interleukin 1 alpha	Homo sapiens	157-161
3112227-3	1987	The findings that i) PFA-fixed Mo did not produce or release IL 1, ii) the accessory function of PFA-fixed Mo could be inhibited with pretreatment with anti-IL 1 antibody, iii) PFA-fixed Mo had a comitogenic effect in the murine thymocyte assay, and iv) there was a temporal difference between the capacities to function in the comitogenic assay and to produce soluble IL 1, suggest that human Mo can express membrane-associated IL 1 and that it is functionally relevant.	paraform	97-100	interleukin 1 alpha	Homo sapiens	157-161
3120512-0	1987	Phospholipase A2 activation by interleukin 1: release and metabolism of arachidonic acid by IL 1-stimulated rabbit chondrocytes.	Arachidonic Acid	72-88	interleukin 1 alpha	Homo sapiens	92-96
3120512-4	1987	IL 1 treatment of chondrocytes which had been prelabeled with [14C]arachidonic acid resulted in an enhanced release of free arachidonic acid identified by thin-layer chromatography.	[14c]arachidonic acid	62-83	interleukin 1 alpha	Homo sapiens	0-4
3120512-4	1987	IL 1 treatment of chondrocytes which had been prelabeled with [14C]arachidonic acid resulted in an enhanced release of free arachidonic acid identified by thin-layer chromatography.	Arachidonic Acid	67-83	interleukin 1 alpha	Homo sapiens	0-4
3500594-5	1987	Of the disease modifying agents tested, levamisole was ineffective while the antimalarials, chloroquine (100 microM) and hydroxychloroquine (100 microM), inhibited the action of IL-1.	Chloroquine	92-103	interleukin 1 alpha	Homo sapiens	178-182
3500594-5	1987	Of the disease modifying agents tested, levamisole was ineffective while the antimalarials, chloroquine (100 microM) and hydroxychloroquine (100 microM), inhibited the action of IL-1.	Hydroxychloroquine	121-139	interleukin 1 alpha	Homo sapiens	178-182
3496391-4	1987	Release of IL 1 induced by suboptimal amounts of C3a(C3adesArg) was greatly enhanced by the addition of indomethacin to the culture medium.	Indomethacin	104-116	interleukin 1 alpha	Homo sapiens	11-15
3111768-15	1987	In contrast to lectins and anti-CD3 mAb phorbol-12-myristate-13-acetate (PMA) induced on its own a modest proliferative response which was greatly enhanced by r-h IL-1 independent of the addition of monocytes.	Tetradecanoylphorbol Acetate	40-71	interleukin 1 alpha	Homo sapiens	163-167
3111768-15	1987	In contrast to lectins and anti-CD3 mAb phorbol-12-myristate-13-acetate (PMA) induced on its own a modest proliferative response which was greatly enhanced by r-h IL-1 independent of the addition of monocytes.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 alpha	Homo sapiens	163-167
3297891-1	1987	The effects of interleukin 1 (IL-1) on glucose-induced insulin secretion from isolated rat islets of Langerhans have been examined.	Glucose	39-46	interleukin 1 alpha	Homo sapiens	30-34
3297891-9	1987	In addition to the inhibitory effects of IL-1 on glucose-induced insulin secretion, purified IL-1 and human rIL-1 had stimulatory effects on glucose-induced insulin secretion under the following conditions: a 90-min incubation with purified IL-1 (10% vol/vol) or in the presence of human rIL-1 (1400 pM) or a 15-h incubation with relatively low concentrations of human rIL-1 (0.5 or 5 pM).	Glucose	141-148	interleukin 1 alpha	Homo sapiens	93-97
3297891-9	1987	In addition to the inhibitory effects of IL-1 on glucose-induced insulin secretion, purified IL-1 and human rIL-1 had stimulatory effects on glucose-induced insulin secretion under the following conditions: a 90-min incubation with purified IL-1 (10% vol/vol) or in the presence of human rIL-1 (1400 pM) or a 15-h incubation with relatively low concentrations of human rIL-1 (0.5 or 5 pM).	Glucose	141-148	interleukin 1 alpha	Homo sapiens	93-97
3040777-0	1987	Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin-1, and epidermal growth factor in human fibroblasts.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	95-108
3040777-8	1987	Dexamethasone inhibited the increase of IFN-beta 2 mRNA levels by IL-1 or TNF.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	66-70
3040777-10	1987	Since IFNs suppress cell growth, inhibition of endogenous IFN-beta synthesis may also be responsible for the amplification by dexamethasone of the growth-stimulating action of TNF and IL-1.	Dexamethasone	126-139	interleukin 1 alpha	Homo sapiens	184-188
3497177-6	1987	Cultured human keratinocytes contain detectable amounts of IL-1 alpha and beta mRNA and protein in the absence of apparent stimulation; these levels could be significantly enhanced 6 h after exposure to 10 ng/ml of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-252	interleukin 1 alpha	Homo sapiens	59-69
3497177-6	1987	Cultured human keratinocytes contain detectable amounts of IL-1 alpha and beta mRNA and protein in the absence of apparent stimulation; these levels could be significantly enhanced 6 h after exposure to 10 ng/ml of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	254-257	interleukin 1 alpha	Homo sapiens	59-69
3501579-0	1987	Stereospecific inhibition of human epidermal cell interleukin-1 secretion and HLA-DR expression by cis-urocanic acid.	cis-Urocanic acid	99-116	interleukin 1 alpha	Homo sapiens	50-63
3501579-3	1987	Cis-UCA but not trans-UCA suppressed interleukin-1 (IL-1) production by epidermal cell suspensions in a dose-dependent fashion and diminished the number of HLA-DR positive epidermal cells to 61% of control values.	cis-Urocanic acid	0-7	interleukin 1 alpha	Homo sapiens	37-50
3501579-3	1987	Cis-UCA but not trans-UCA suppressed interleukin-1 (IL-1) production by epidermal cell suspensions in a dose-dependent fashion and diminished the number of HLA-DR positive epidermal cells to 61% of control values.	cis-Urocanic acid	0-7	interleukin 1 alpha	Homo sapiens	52-56
3495597-1	1987	Membrane-associated interleukin 1 (IL 1) activity was induced on the human macrophage tumor cell line, U937, by pretreatment with phorbol myristic acid (PMA).	phorbol-12-myristate	130-151	interleukin 1 alpha	Homo sapiens	0-39
3497458-2	1987	This study asked three questions: Does IL-1 increase the corticosterone levels of rat serum?	Corticosterone	57-71	interleukin 1 alpha	Homo sapiens	39-43
3497458-5	1987	The intraperitoneal injection of IL-1 (70 micrograms) in anesthetized male Fisher rats resulted in elevated corticosterone levels at 30 minutes and reached a maximum at 180 minutes (94 +/- 12 versus 34 +/- 4 micrograms/dl, p less than 0.01).	Corticosterone	108-122	interleukin 1 alpha	Homo sapiens	33-37
3497458-7	1987	Corticosterone secretion was significantly increased (p less than 0.01) 90 minutes after a single arterial bolus of 35 micrograms of IL-1.	Corticosterone	0-14	interleukin 1 alpha	Homo sapiens	133-137
3497458-9	1987	The addition of indomethacin (3 mumol/L) completely abolished the stimulatory effect of IL-1.	Indomethacin	16-28	interleukin 1 alpha	Homo sapiens	88-92
3497458-10	1987	This study demonstrates that IL-1 increases rat serum corticosterone levels, IL-1 directly stimulates the adrenal cortex, and the stimulation may be mediated through prostaglandin synthesis.	Corticosterone	54-68	interleukin 1 alpha	Homo sapiens	29-33
3497458-10	1987	This study demonstrates that IL-1 increases rat serum corticosterone levels, IL-1 directly stimulates the adrenal cortex, and the stimulation may be mediated through prostaglandin synthesis.	Prostaglandins	166-179	interleukin 1 alpha	Homo sapiens	29-33
3496120-2	1987	To minimize the effects of transient prostaglanding E2 production in fibroblasts treated with interleukin-1, the cell cultures were preincubated for 24 h before these measurements were made.	prostaglanding e2	37-54	interleukin 1 alpha	Homo sapiens	94-107
3112179-4	1987	Physiologic saline contaminated with bacterial toxins was passed through a hollow fiber ultrafilter, and the ultrafiltrates were tested for their ability to induce human IL-1 production.	Sodium Chloride	12-18	interleukin 1 alpha	Homo sapiens	170-174
3495597-1	1987	Membrane-associated interleukin 1 (IL 1) activity was induced on the human macrophage tumor cell line, U937, by pretreatment with phorbol myristic acid (PMA).	phorbol-12-myristate	153-156	interleukin 1 alpha	Homo sapiens	0-39
3495597-6	1987	Membrane-associated IL 1 induced a more potent PGE2 response than did a maximal concentration of soluble IL 1.	Dinoprostone	47-51	interleukin 1 alpha	Homo sapiens	20-24
3495597-7	1987	Rabbit antihuman IL 1 neutralized membrane-bound IL 1 induction of PGE2.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	17-21
3495597-7	1987	Rabbit antihuman IL 1 neutralized membrane-bound IL 1 induction of PGE2.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	49-53
3495602-3	1987	No demonstrable IL-1 beta protein could be observed on the cell surface by antibody staining, while both IL-1 alpha and IL-1 beta could be visualized intracellularly by the appropriate monoclonal antibodies following acetone permeabilization of the monocytes.	Acetone	217-224	interleukin 1 alpha	Homo sapiens	105-115
2438337-6	1987	Furthermore, addition of either purified human IL 1 or recombinant human IL 1 to adherent cell-depleted cultures reconstituted reactivity to GPMBP in the EAE transfer activation assay and augmented GPMBP-specific proliferative responses.	gpmbp	141-146	interleukin 1 alpha	Homo sapiens	47-51
3036952-4	1987	Thus, the biological activities of the growth factors IL-2 or IL-1 could be detected and quantitated at the same level of sensitivity as with the conventional [3H]thymidine incorporation.	Tritium	160-162	interleukin 1 alpha	Homo sapiens	62-66
2953802-1	1987	The expression of interleukin 1 receptors (IL 1R) on human peripheral T cells was studied by the binding assay with 125I-labeled recombinant human interleukin 1 (IL 1) alpha and IL 1 beta and by the flow cytofluorometry with the fluorescein isothiocyanate (FITC)-conjugated IL 1 alpha.	Iodine-125	116-120	interleukin 1 alpha	Homo sapiens	147-173
2953802-5	1987	Furthermore the binding of 125I-labeled IL 1 alpha to IL 1R on T cells was inhibited by the addition of either cold IL 1 alpha or IL beta, but not by interleukin 2 or interferons.	Iodine-125	27-31	interleukin 1 alpha	Homo sapiens	40-50
2953802-5	1987	Furthermore the binding of 125I-labeled IL 1 alpha to IL 1R on T cells was inhibited by the addition of either cold IL 1 alpha or IL beta, but not by interleukin 2 or interferons.	Iodine-125	27-31	interleukin 1 alpha	Homo sapiens	116-126
2953802-11	1987	The maximum IL 1R-positive T cells were approximately 30% by the detection of the flow cytofluorometry with FITC-conjugated IL 1 alpha.	Fluorescein-5-isothiocyanate	108-112	interleukin 1 alpha	Homo sapiens	124-134
3495584-6	1987	The IL 1 activity in the purified cytosol, prepared by extraction with digitonin, was considerably increased by the trypsin treatment, whereas the increase in IL 1 activity within crude lysosomes and plasma membranes was less.	Digitonin	71-80	interleukin 1 alpha	Homo sapiens	4-8
2438337-6	1987	Furthermore, addition of either purified human IL 1 or recombinant human IL 1 to adherent cell-depleted cultures reconstituted reactivity to GPMBP in the EAE transfer activation assay and augmented GPMBP-specific proliferative responses.	gpmbp	141-146	interleukin 1 alpha	Homo sapiens	73-77
2438337-6	1987	Furthermore, addition of either purified human IL 1 or recombinant human IL 1 to adherent cell-depleted cultures reconstituted reactivity to GPMBP in the EAE transfer activation assay and augmented GPMBP-specific proliferative responses.	gpmbp	198-203	interleukin 1 alpha	Homo sapiens	47-51
2438337-6	1987	Furthermore, addition of either purified human IL 1 or recombinant human IL 1 to adherent cell-depleted cultures reconstituted reactivity to GPMBP in the EAE transfer activation assay and augmented GPMBP-specific proliferative responses.	gpmbp	198-203	interleukin 1 alpha	Homo sapiens	73-77
2438337-7	1987	Anti-Ia monoclonal antibodies blocked GPMBP + IL 1-induced cellular activation of nonadherent LNC.	gpmbp	38-43	interleukin 1 alpha	Homo sapiens	46-50
2438337-8	1987	These results demonstrate that both IL 1 and Ia molecules are important in the pathway leading to GPMBP-induced activation of EAE-inducing T lymphocytes.	gpmbp	98-103	interleukin 1 alpha	Homo sapiens	36-40
3497150-4	1987	To determine the possible mechanism(s) involved in the inhibition of MNL proliferation following exposure to pefloxacin, ciprofloxacin or ofloxacin, we assessed (1) interleukin-1 (IL-1) activity in supernatants from monocytes treated with the quinolones and (2) the effects of 2-mercaptoethanol (2-ME) a thiol compound which acts as an antioxidant agent and the effect of indomethacin (INDO) an inhibitor of prostaglandin E2 synthesis.	Pefloxacin	109-119	interleukin 1 alpha	Homo sapiens	165-184
3497150-4	1987	To determine the possible mechanism(s) involved in the inhibition of MNL proliferation following exposure to pefloxacin, ciprofloxacin or ofloxacin, we assessed (1) interleukin-1 (IL-1) activity in supernatants from monocytes treated with the quinolones and (2) the effects of 2-mercaptoethanol (2-ME) a thiol compound which acts as an antioxidant agent and the effect of indomethacin (INDO) an inhibitor of prostaglandin E2 synthesis.	Ciprofloxacin	121-134	interleukin 1 alpha	Homo sapiens	165-184
3498828-4	1987	When the intracerebroventricular infusion of interleukin-1 was preceded by a bilateral injection of saline into the ventral septal area, the resulting febrile response was not different from that induced by interleukin-1 alone.	Sodium Chloride	100-106	interleukin 1 alpha	Homo sapiens	45-58
3495574-3	1987	We characterized the effects on PG production by confluent normal lung fibroblasts of recombinant interleukin 1 alpha (IL 1 alpha), interleukin 1 beta (IL 1 beta) and tumor necrosis factor (TNF), alone and in combination.	Prostaglandins	32-34	interleukin 1 alpha	Homo sapiens	98-117
3495574-3	1987	We characterized the effects on PG production by confluent normal lung fibroblasts of recombinant interleukin 1 alpha (IL 1 alpha), interleukin 1 beta (IL 1 beta) and tumor necrosis factor (TNF), alone and in combination.	Prostaglandins	32-34	interleukin 1 alpha	Homo sapiens	119-129
3495574-5	1987	In addition, TNF interacted in a synergistic fashion with both IL 1 peptides to augment fibroblast PGE elaboration further.	Prostaglandins E	99-102	interleukin 1 alpha	Homo sapiens	63-67
3495577-5	1987	Cycloheximide inhibition of new protein synthesis causes a superinduction of IL 1 message, but does not alter the initial kinetics of message production.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	77-81
3033070-5	1987	MSU-induced supernatants with IL 1 activity were neutralized with rabbit antiserum to human IL 1 and also stimulated the growth ([3H]thymidine incorporation) of long-term fibroblast-like cell lines derived from human synovial rheumatoid exudate.	Tritium	130-132	interleukin 1 alpha	Homo sapiens	30-34
3108877-6	1987	The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP-dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide-dependent protein kinases.	Cyclic AMP	148-152	interleukin 1 alpha	Homo sapiens	49-94
3033070-5	1987	MSU-induced supernatants with IL 1 activity were neutralized with rabbit antiserum to human IL 1 and also stimulated the growth ([3H]thymidine incorporation) of long-term fibroblast-like cell lines derived from human synovial rheumatoid exudate.	Thymidine	133-142	interleukin 1 alpha	Homo sapiens	30-34
3494502-6	1987	Partial purification of JOSK-I-derived IL-1 was performed by high-performance liquid chromatography on HPHT hydroxylapatite and TSK gel G3000 SW columns.	hpht hydroxylapatite	103-123	interleukin 1 alpha	Homo sapiens	39-43
3033070-7	1987	As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release.	Uric Acid	324-329	interleukin 1 alpha	Homo sapiens	84-88
3033070-7	1987	As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release.	Uric Acid	324-329	interleukin 1 alpha	Homo sapiens	222-226
3494766-9	1987	In contrast to the actions of LT or TNF, pretreatment with IL 1 alpha or IL 1 beta only partially inhibited induction of H4/18 binding by phorbol ester, and phorbol ester pretreatment consistently, albeit partially, inhibited induction by IL 1 species.	Phorbol Esters	138-151	interleukin 1 alpha	Homo sapiens	59-69
3494766-9	1987	In contrast to the actions of LT or TNF, pretreatment with IL 1 alpha or IL 1 beta only partially inhibited induction of H4/18 binding by phorbol ester, and phorbol ester pretreatment consistently, albeit partially, inhibited induction by IL 1 species.	Phorbol Esters	138-151	interleukin 1 alpha	Homo sapiens	59-63
3033070-7	1987	As a model for the inflammatory consequences of acute and chronic overproduction of IL 1, gout is the only sterile inflammatory disease where the local and systemic pathology is compatible with such overproduction; raised IL 1 levels have been found at the site of inflammation, and a necessary etiologic agent, crystalline urate, has been shown unequivocally to be a direct activator of mononuclear IL 1 release.	Uric Acid	324-329	interleukin 1 alpha	Homo sapiens	222-226
3109443-0	1987	Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells.	Dinoprostone	92-108	interleukin 1 alpha	Homo sapiens	23-42
3494787-1	1987	A microtechnique is described for inducing IL-1 activity in vitro from frozen human blood mononuclear cells (BMNC) using the lymphocyte-activating factor (LAF) method.	microtechnique	2-16	interleukin 1 alpha	Homo sapiens	43-47
3555119-0	1987	Interleukin-1 decreases renal sodium reabsorption: possible mechanism of endotoxin-induced natriuresis.	Sodium	30-36	interleukin 1 alpha	Homo sapiens	0-13
3109443-3	1987	We report here that samples of purified human interleukin-1 beta (IL-1 beta) and recombinant IL-1 alpha stimulate both the plasminogen activator activity and prostaglandin E2 levels of human synovial fibroblast-like cells.	Dinoprostone	158-174	interleukin 1 alpha	Homo sapiens	93-103
2436818-1	1987	In a previous work we have reported that gangliosides inhibit interleukin 1 (IL-1) release by human monocytes stimulated with lipopolysaccharides (LPS).	Gangliosides	41-53	interleukin 1 alpha	Homo sapiens	77-81
2436818-0	1987	Inhibition by gangliosides of the specific binding of lipopolysaccharide (LPS) to human monocytes prevents LPS-induced interleukin-1 production.	Gangliosides	14-26	interleukin 1 alpha	Homo sapiens	119-132
2436818-2	1987	In the present study we extend this work to IL-1 production and we correlate these observations with the capacity of gangliosides to inhibit the binding of radiolabeled LPS to its specific receptor on human monocytes.	Gangliosides	117-129	interleukin 1 alpha	Homo sapiens	44-48
2436818-8	1987	Addition of exogenous sialogangliosides which blocked LPS-induced IL-1 production and release, did not modify significantly the nonspecific binding of 3H-LPS, whereas it did inhibit the specific binding which is mediated by the polysaccharide moiety of the LPS molecule.	sialogangliosides	22-39	interleukin 1 alpha	Homo sapiens	66-70
3494774-3	1987	The human astrocytoma U373 was found to incorporate [3H]thymidine after exposure to recombinant human IL 1 alpha and IL 1 beta and murine IL 1 alpha.	3h]thymidine	53-65	interleukin 1 alpha	Homo sapiens	102-112
3495548-12	1987	We conclude that the increase in neutralization of bacterial lipopolysaccharide by serum samples drawn from patients with inflammatory states is mediated, at least in part, by interleukin-1, presumably through the induction of acute-phase serum proteins.	bacterial lipopolysaccharide	51-79	interleukin 1 alpha	Homo sapiens	176-189
3106491-0	1987	Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes.	Prostaglandins	40-53	interleukin 1 alpha	Homo sapiens	18-31
3106491-2	1987	When the cells were pretreated for 8 to 9 hr with either E. coli lipopolysaccharide or recombinant interleukin 1 (beta), prostaglandin release increased.	Prostaglandins	121-134	interleukin 1 alpha	Homo sapiens	99-112
3106491-6	1987	These data suggest antagonistic roles for interleukin 1 and interferon in the regulation of eicosanoid release from monocytes.	Eicosanoids	92-102	interleukin 1 alpha	Homo sapiens	42-70
3494807-6	1987	IL-1 alpha mRNA was detected in SMC treated with cycloheximide (1 microgram/ml) and rIL-1 beta, or cycloheximide alone.	Cycloheximide	49-62	interleukin 1 alpha	Homo sapiens	0-10
3494807-6	1987	IL-1 alpha mRNA was detected in SMC treated with cycloheximide (1 microgram/ml) and rIL-1 beta, or cycloheximide alone.	Cycloheximide	99-112	interleukin 1 alpha	Homo sapiens	0-10
3034257-1	1987	Interleukin 1, a product predominantly of monocytes, increases the synthesis and release of procollagenase and prostaglandin E2 by mesenchymal target cells such as synovial fibroblasts and articular chondrocytes, an effect mimicked by some phorbol esters.	Dinoprostone	111-127	interleukin 1 alpha	Homo sapiens	0-13
3114488-2	1987	Recombinant Interleukin-1 (IL-1) which stimulates the synthesis of prostaglandin E2 (PGE2), collagenase, and plasminogen activator also stimulates the synthesis of collagen and increases steady-state levels of mRNA in cultured chondrocytes, synovial cells and foreskin fibroblasts if the synthesis of PGE2, which inhibits collagen synthesis, is inhibited by indomethacin.	Dinoprostone	67-83	interleukin 1 alpha	Homo sapiens	12-31
3114488-2	1987	Recombinant Interleukin-1 (IL-1) which stimulates the synthesis of prostaglandin E2 (PGE2), collagenase, and plasminogen activator also stimulates the synthesis of collagen and increases steady-state levels of mRNA in cultured chondrocytes, synovial cells and foreskin fibroblasts if the synthesis of PGE2, which inhibits collagen synthesis, is inhibited by indomethacin.	Dinoprostone	85-89	interleukin 1 alpha	Homo sapiens	12-31
3114488-2	1987	Recombinant Interleukin-1 (IL-1) which stimulates the synthesis of prostaglandin E2 (PGE2), collagenase, and plasminogen activator also stimulates the synthesis of collagen and increases steady-state levels of mRNA in cultured chondrocytes, synovial cells and foreskin fibroblasts if the synthesis of PGE2, which inhibits collagen synthesis, is inhibited by indomethacin.	Dinoprostone	301-305	interleukin 1 alpha	Homo sapiens	12-31
3114488-2	1987	Recombinant Interleukin-1 (IL-1) which stimulates the synthesis of prostaglandin E2 (PGE2), collagenase, and plasminogen activator also stimulates the synthesis of collagen and increases steady-state levels of mRNA in cultured chondrocytes, synovial cells and foreskin fibroblasts if the synthesis of PGE2, which inhibits collagen synthesis, is inhibited by indomethacin.	Indomethacin	358-370	interleukin 1 alpha	Homo sapiens	12-31
3034257-1	1987	Interleukin 1, a product predominantly of monocytes, increases the synthesis and release of procollagenase and prostaglandin E2 by mesenchymal target cells such as synovial fibroblasts and articular chondrocytes, an effect mimicked by some phorbol esters.	Phorbol Esters	240-254	interleukin 1 alpha	Homo sapiens	0-13
2435789-4	1987	Recombinant IL 1 (rIL 1) given shortly after the tolerogen DHGG results in the inhibition of the induction of tolerance resulting in antibody production.	dhgg	59-63	interleukin 1 alpha	Homo sapiens	12-16
2435800-7	1987	Lastly, purified human IL 1 increased the clonal efficiency of ROHA-9 cells seeded at a low cell concentration, allowing the isolation of the ROHA-9MC3 subclone, which showed similar growth response specificity and was particularly sensitive to the mitogenic activity of human IL 1.	roha-9mc3	142-151	interleukin 1 alpha	Homo sapiens	23-27
3494075-0	1987	Evidence that recombinant IL 1 alpha exhibits lectin-like specificity and binds to homogeneous uromodulin via N-linked oligosaccharides.	n-linked oligosaccharides	110-135	interleukin 1 alpha	Homo sapiens	26-36
3494075-4	1987	Furthermore, oligosaccharides isolated from pronase-digested uromodulin are immunosuppressive by themselves and are able to compete with native uromodulin for binding to IL 1.	Oligosaccharides	13-29	interleukin 1 alpha	Homo sapiens	170-174
3496323-0	1987	Effects of quinolones on interleukin 1 production in vitro by human monocytes.	Quinolones	11-21	interleukin 1 alpha	Homo sapiens	25-38
3496323-3	1987	Pefloxacin and ciprofloxacin decreased the extracellular IL-1 in a dose-dependent manner, while cell-associated IL-1 was not altered.	Pefloxacin	0-10	interleukin 1 alpha	Homo sapiens	57-61
3496323-3	1987	Pefloxacin and ciprofloxacin decreased the extracellular IL-1 in a dose-dependent manner, while cell-associated IL-1 was not altered.	Ciprofloxacin	15-28	interleukin 1 alpha	Homo sapiens	57-61
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Pefloxacin	46-56	interleukin 1 alpha	Homo sapiens	30-34
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Pefloxacin	46-56	interleukin 1 alpha	Homo sapiens	227-231
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Ciprofloxacin	61-74	interleukin 1 alpha	Homo sapiens	30-34
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Ciprofloxacin	61-74	interleukin 1 alpha	Homo sapiens	227-231
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Pefloxacin	316-326	interleukin 1 alpha	Homo sapiens	30-34
3496323-7	1987	The decrease of extracellular IL-1 induced by pefloxacin and ciprofloxacin could, in part, account for the observed decrease in the proliferative response of human mononuclear leukocytes to phytohemagglutinin, as extracellular IL-1 and proliferative response were positively correlated (at various concentrations of pefloxacin and ciprofloxacin).	Ciprofloxacin	331-344	interleukin 1 alpha	Homo sapiens	30-34
3496323-9	1987	These data suggested that pefloxacin and ciprofloxacin could antagonize IL-1 production and release by lipopolysaccharide-stimulated monocytes.	Pefloxacin	26-36	interleukin 1 alpha	Homo sapiens	72-76
3496323-9	1987	These data suggested that pefloxacin and ciprofloxacin could antagonize IL-1 production and release by lipopolysaccharide-stimulated monocytes.	Ciprofloxacin	41-54	interleukin 1 alpha	Homo sapiens	72-76
3496323-10	1987	These quinolones could be interesting tools to study the production, processing, transport and release from the monocytes of IL-1.	Quinolones	6-16	interleukin 1 alpha	Homo sapiens	125-129
2951435-1	1987	Interleukin 1 (IL 1) receptors were solubilized from membranes prepared from murine EL-4 thymoma cells with the zwitterionic detergent 3[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS).	[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate	136-192	interleukin 1 alpha	Homo sapiens	15-19
2951435-1	1987	Interleukin 1 (IL 1) receptors were solubilized from membranes prepared from murine EL-4 thymoma cells with the zwitterionic detergent 3[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS).	3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	194-199	interleukin 1 alpha	Homo sapiens	15-19
2951435-3	1987	Concentrations of CHAPS from 4 to 8 mM were effective in solubilizing the IL 1 receptor.	3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	18-23	interleukin 1 alpha	Homo sapiens	74-78
3031157-5	1987	Second, preincubation of the EC with low doses of the inhibitors (0.1 to 1 microgram/ml) in the absence of IL 1 consistently increased T-EC binding, even if the inhibitors were present during the T-EC adhesion assay; in addition, the inhibitors additionally increased the stimulatory effect of IL 1 if the EC were washed free of the inhibitor before the assay step.	t-ec	135-139	interleukin 1 alpha	Homo sapiens	107-111
2435789-7	1987	IL 1 mimics lipopolysaccharide and 8-bromoguanosine, which generate IL 1 production, in its ability to interfere with the in vivo induction of tolerance.	8-bromoguanosine	35-51	interleukin 1 alpha	Homo sapiens	0-4
2435789-7	1987	IL 1 mimics lipopolysaccharide and 8-bromoguanosine, which generate IL 1 production, in its ability to interfere with the in vivo induction of tolerance.	8-bromoguanosine	35-51	interleukin 1 alpha	Homo sapiens	68-72
3495707-10	1987	This study supports the hypothesis that hemodialysis with regenerated cellulose might augment IL-1 production in endstage renal disease patients maintained on longterm hemodialysis.	Cellulose	70-79	interleukin 1 alpha	Homo sapiens	94-98
3492551-3	1987	The purity of the IL 1 was assessed by fluorography of one- and two-dimensional SDS-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	80-83	interleukin 1 alpha	Homo sapiens	18-22
3029220-8	1987	Specifically, this steroid augments D10 proliferation at low concentrations of recombinant IL 1, but as the abundance of the monokine increases in the presence of 10(-10) to 10(-8) M 1,25(OH)2D3, the peak response of D10 cells to optimal IL 1 concentrations is diminished.	Steroids	19-26	interleukin 1 alpha	Homo sapiens	91-95
3029220-8	1987	Specifically, this steroid augments D10 proliferation at low concentrations of recombinant IL 1, but as the abundance of the monokine increases in the presence of 10(-10) to 10(-8) M 1,25(OH)2D3, the peak response of D10 cells to optimal IL 1 concentrations is diminished.	Steroids	19-26	interleukin 1 alpha	Homo sapiens	238-242
3112200-7	1987	BP was a specific IL-1 inhibitor, and did not inhibit thymocyte proliferation in the standard IL-1 bioassay in the absence of IL-1.	Benzo(a)pyrene	0-2	interleukin 1 alpha	Homo sapiens	18-22
3492551-3	1987	The purity of the IL 1 was assessed by fluorography of one- and two-dimensional SDS-polyacrylamide gel electrophoresis.	polyacrylamide gels	84-102	interleukin 1 alpha	Homo sapiens	18-22
3494301-2	1987	When the polysaccharides were presented to the macrophages in a sterically fixed form, i.e. as microparticles, they induced the release of interleukin 1 (IL-1) from the macrophages.	Polysaccharides	9-24	interleukin 1 alpha	Homo sapiens	139-158
3494301-10	1987	When cyclo-oxygenase was blocked with indomethacin, a significantly higher release of IL-1, and then an increased cytotoxicity, were obtained with 1.3-beta-glucan stimulated macrophages.	Indomethacin	38-50	interleukin 1 alpha	Homo sapiens	86-90
3494301-10	1987	When cyclo-oxygenase was blocked with indomethacin, a significantly higher release of IL-1, and then an increased cytotoxicity, were obtained with 1.3-beta-glucan stimulated macrophages.	3-beta-glucan	149-162	interleukin 1 alpha	Homo sapiens	86-90
3493776-5	1987	Even after fractionation on hydroxyapatite HPLC the IL 1-dependent D-factor was co-chromatographed with TNF.	Durapatite	28-42	interleukin 1 alpha	Homo sapiens	52-56
3100335-1	1987	The ability of interleukin-1 (IL-1) to stimulate prostaglandin E2 (PGE2) production by human rheumatoid adherent synovial cells was found to be time-dependent and sensitive to protein synthesis inhibitors.	Dinoprostone	49-65	interleukin 1 alpha	Homo sapiens	15-28
3100335-1	1987	The ability of interleukin-1 (IL-1) to stimulate prostaglandin E2 (PGE2) production by human rheumatoid adherent synovial cells was found to be time-dependent and sensitive to protein synthesis inhibitors.	Dinoprostone	49-65	interleukin 1 alpha	Homo sapiens	30-34
3100335-1	1987	The ability of interleukin-1 (IL-1) to stimulate prostaglandin E2 (PGE2) production by human rheumatoid adherent synovial cells was found to be time-dependent and sensitive to protein synthesis inhibitors.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	15-28
3100335-1	1987	The ability of interleukin-1 (IL-1) to stimulate prostaglandin E2 (PGE2) production by human rheumatoid adherent synovial cells was found to be time-dependent and sensitive to protein synthesis inhibitors.	Dinoprostone	67-71	interleukin 1 alpha	Homo sapiens	30-34
3100335-3	1987	However, with IL-1 (2.5 U/ml) and exogenous arachidonic acid there was a marked increase, with levels reaching twice that for cells incubated with IL-1 alone.	Arachidonic Acid	44-60	interleukin 1 alpha	Homo sapiens	147-151
3100335-4	1987	Aspirin pre-treatment studies and the use of [acetyl-14C]aspirin showed that IL-1 increased PGE2 production through the induction of cyclo-oxygenase.	Aspirin	0-7	interleukin 1 alpha	Homo sapiens	77-81
3100335-4	1987	Aspirin pre-treatment studies and the use of [acetyl-14C]aspirin showed that IL-1 increased PGE2 production through the induction of cyclo-oxygenase.	[acetyl-14c]aspirin	45-64	interleukin 1 alpha	Homo sapiens	77-81
3100335-4	1987	Aspirin pre-treatment studies and the use of [acetyl-14C]aspirin showed that IL-1 increased PGE2 production through the induction of cyclo-oxygenase.	Dinoprostone	92-96	interleukin 1 alpha	Homo sapiens	77-81
3542082-6	1987	PAF synthesis was stimulated by murine and human recombinant IL 1 alpha but not by human recombinant IL 1 beta and 22K factor.	Platelet Activating Factor	0-3	interleukin 1 alpha	Homo sapiens	61-71
3038436-2	1987	IL-1 activity of the monocyte culture supernatant without indomethacin was decreased in patients with HCC and LC, compared with that of controls.	Indomethacin	58-70	interleukin 1 alpha	Homo sapiens	0-4
3038436-7	1987	The decrease in IL-1 activity of the supernatant without indomethacin of patients with LC and HCC was considered to be due to increased secretion of PGE2 by the monocytes.	Dinoprostone	149-153	interleukin 1 alpha	Homo sapiens	16-20
3493176-3	1987	IL-1 induces prostaglandin and fibrinogen synthesis and stimulates fibroblast proliferation.	Prostaglandins	13-26	interleukin 1 alpha	Homo sapiens	0-4
3024738-2	1987	After 2 h stimulation with interleukin 1, 1-O-alkyl-2-lysoglycero-3-phosphocholine (GPC): acetyl CoA acetyltransferase is activated, reaching a plateau after 6 h and then declining to the basal value within 24 h. This time course is comparable to that of PAF production.	-3-phosphocholine	65-82	interleukin 1 alpha	Homo sapiens	27-40
3027706-2	1987	The parental cell line 84.5, a deletion mutant of the 721 LCL cell line, can be induced to produce IL-1 activity when stimulated by certain inducers such as phorbol 12-myristate 13-acetate in the presence of fetal calf serum.	Tetradecanoylphorbol Acetate	157-188	interleukin 1 alpha	Homo sapiens	99-103
3028403-1	1987	Stimulation of [3H]-arachidonic acid labeled human synovial cells with 3.0 X 10(-10)M recombinant interleukin-1 or tumor necrosis factor resulted in the release of incorporated radiolabel (41.1% and 27.7% respectively).	Tritium	16-18	interleukin 1 alpha	Homo sapiens	98-136
3024738-2	1987	After 2 h stimulation with interleukin 1, 1-O-alkyl-2-lysoglycero-3-phosphocholine (GPC): acetyl CoA acetyltransferase is activated, reaching a plateau after 6 h and then declining to the basal value within 24 h. This time course is comparable to that of PAF production.	Platelet Activating Factor	255-258	interleukin 1 alpha	Homo sapiens	27-40
3028403-1	1987	Stimulation of [3H]-arachidonic acid labeled human synovial cells with 3.0 X 10(-10)M recombinant interleukin-1 or tumor necrosis factor resulted in the release of incorporated radiolabel (41.1% and 27.7% respectively).	Arachidonic Acid	20-36	interleukin 1 alpha	Homo sapiens	98-136
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Tritium	13-15	interleukin 1 alpha	Homo sapiens	68-107
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Arachidonic Acid	17-33	interleukin 1 alpha	Homo sapiens	68-107
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Phospholipids	42-55	interleukin 1 alpha	Homo sapiens	68-107
2879093-0	1987	Enhancement of in-vitro human interleukin-1 production by sodium acetate.	Sodium Acetate	58-72	interleukin 1 alpha	Homo sapiens	30-43
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Tritium	13-16	interleukin 1 alpha	Homo sapiens	68-107
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Arachidonic Acid	124-140	interleukin 1 alpha	Homo sapiens	68-107
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	phosphatidyl-choline phosphatidylserine	144-183	interleukin 1 alpha	Homo sapiens	68-107
3028403-2	1987	Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidyl-choline phosphatidylserine and phosphatidylinositol.	Phosphatidylinositols	188-208	interleukin 1 alpha	Homo sapiens	68-107
3098847-4	1987	Conditioned media from stimulated human peripheral blood mononuclear cells; purified human monocyte IL 1, pI 7,6, and 5; and recombinant human IL 1, beta or alpha forms, all changed the secretory pattern of rabbit articular chondrocytes in a similar manner: production and secretion of a latent metalloproteinase(s) and prostaglandin E were stimulated in a concentration-dependent fashion, whereas the activity of plasminogen activator was strongly reduced.	Prostaglandins E	320-335	interleukin 1 alpha	Homo sapiens	143-147
3098847-6	1987	When added to confluent chondrocytes, phorbol myristate acetate, concanavalin A, IL 2, lipopolysaccharide, indomethacin, and prostaglandin E2, which interfere with lymphocyte proliferation assays for IL 1, failed to influence chondrocyte metalloproteinase secretion.	Tetradecanoylphorbol Acetate	38-63	interleukin 1 alpha	Homo sapiens	200-204
3098847-6	1987	When added to confluent chondrocytes, phorbol myristate acetate, concanavalin A, IL 2, lipopolysaccharide, indomethacin, and prostaglandin E2, which interfere with lymphocyte proliferation assays for IL 1, failed to influence chondrocyte metalloproteinase secretion.	Dinoprostone	125-141	interleukin 1 alpha	Homo sapiens	200-204
2879093-3	1987	The production of intracellular IL-1 and the release of extracellular IL-1 were higher in the presence of acetate than in the presence of chloride or in medium alone.	Acetates	106-113	interleukin 1 alpha	Homo sapiens	32-36
2879093-3	1987	The production of intracellular IL-1 and the release of extracellular IL-1 were higher in the presence of acetate than in the presence of chloride or in medium alone.	Acetates	106-113	interleukin 1 alpha	Homo sapiens	70-74
2879093-3	1987	The production of intracellular IL-1 and the release of extracellular IL-1 were higher in the presence of acetate than in the presence of chloride or in medium alone.	Chlorides	138-146	interleukin 1 alpha	Homo sapiens	32-36
2879093-3	1987	The production of intracellular IL-1 and the release of extracellular IL-1 were higher in the presence of acetate than in the presence of chloride or in medium alone.	Chlorides	138-146	interleukin 1 alpha	Homo sapiens	70-74
3492923-0	1987	Interleukin 1-induced depression of iron and zinc: role of granulocytes and lactoferrin.	Iron	36-40	interleukin 1 alpha	Homo sapiens	0-13
2959038-1	1987	The antirejection eicosanoids--PGE2, (PGD2), and PGI2--have an attenuating effect on T-cell proliferation by inhibition of IL-1, IL-2, and class II antigen expression on macrophages, and the prorejection eicosanoids--TXA2, LTB4, LTC4, and LTD4--enhance T-cell proliferation.	Eicosanoids	18-29	interleukin 1 alpha	Homo sapiens	123-127
2959038-1	1987	The antirejection eicosanoids--PGE2, (PGD2), and PGI2--have an attenuating effect on T-cell proliferation by inhibition of IL-1, IL-2, and class II antigen expression on macrophages, and the prorejection eicosanoids--TXA2, LTB4, LTC4, and LTD4--enhance T-cell proliferation.	Dinoprostone	31-35	interleukin 1 alpha	Homo sapiens	123-127
2959038-1	1987	The antirejection eicosanoids--PGE2, (PGD2), and PGI2--have an attenuating effect on T-cell proliferation by inhibition of IL-1, IL-2, and class II antigen expression on macrophages, and the prorejection eicosanoids--TXA2, LTB4, LTC4, and LTD4--enhance T-cell proliferation.	Prostaglandin D2	38-42	interleukin 1 alpha	Homo sapiens	123-127
2959038-1	1987	The antirejection eicosanoids--PGE2, (PGD2), and PGI2--have an attenuating effect on T-cell proliferation by inhibition of IL-1, IL-2, and class II antigen expression on macrophages, and the prorejection eicosanoids--TXA2, LTB4, LTC4, and LTD4--enhance T-cell proliferation.	Epoprostenol	49-53	interleukin 1 alpha	Homo sapiens	123-127
3492161-0	1987	Human alveolar macrophages suppress interleukin-1 (IL-1) activity via the secretion of prostaglandin E2.	Dinoprostone	87-103	interleukin 1 alpha	Homo sapiens	36-49
3492161-0	1987	Human alveolar macrophages suppress interleukin-1 (IL-1) activity via the secretion of prostaglandin E2.	Dinoprostone	87-103	interleukin 1 alpha	Homo sapiens	51-55
3492161-4	1987	After 24 h in culture, the alveolar macrophage supernatants contained sufficient amounts of PGE2 to significantly suppress PHA-induced lymphocyte proliferation (p less than 0.01), IL-1-induced thymocyte proliferation (p less than 0.001), but not IL-2-induced lymphocyte proliferation (p greater than 0.2).	Dinoprostone	92-96	interleukin 1 alpha	Homo sapiens	180-184
3492161-8	1987	These observations suggest that the apparent defect in the release of IL-1 by human alveolar macrophages may be due in part to the release of large amounts of PGE2, which suppresses various lymphocyte functions.	Dinoprostone	159-163	interleukin 1 alpha	Homo sapiens	70-74
2948675-8	1987	PGE2, added at the time of culture initiation, also inhibited T-cell proliferation in cultures which were supplemented with exogenous IL-1 or IL-2.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	134-138
3502240-2	1987	In addition, Il-1 increased the percentage of thymocytes resistant to hydrocortisone.	Hydrocortisone	70-84	interleukin 1 alpha	Homo sapiens	13-17
3502240-5	1987	The activity of Il-1 in the supernatant from macrophage cultures, stimulated with carbonyl iron powder, was calculated.	Iron Carbonyl Compounds	82-95	interleukin 1 alpha	Homo sapiens	16-20
3545852-0	1987	Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts.	Poly C	27-35	interleukin 1 alpha	Homo sapiens	0-13
3109736-6	1987	Therefore, the ability of MMC-treated adherent cells to produce interleukin 1 (IL 1) was examined.	Mitomycin	26-29	interleukin 1 alpha	Homo sapiens	64-83
3109736-8	1987	The results appear to indicate that the selective effects of MMC on the adherent cell fraction, especially the modification of IL 1 production, may be involved in the mechanisms of MMC-induced augmented cell-mediated cytotoxicity.	Mitomycin	61-64	interleukin 1 alpha	Homo sapiens	127-131
3109736-8	1987	The results appear to indicate that the selective effects of MMC on the adherent cell fraction, especially the modification of IL 1 production, may be involved in the mechanisms of MMC-induced augmented cell-mediated cytotoxicity.	Mitomycin	181-184	interleukin 1 alpha	Homo sapiens	127-131
3545852-3	1987	Combined treatment with cycloheximide and actinomycin D also stimulates production and enhances production induced by IL 1 or poly(rI).poly(rC).	Cycloheximide	24-37	interleukin 1 alpha	Homo sapiens	118-122
3311846-1	1987	Endothelial cell activation by endotoxin (LPS), tumor necrosis factor (TNF), Interleukin-1-alpha, beta (IL-1-alpha, beta) and phorbolesters (TPA) results in increased monocyte adhesion.	Tetradecanoylphorbol Acetate	141-144	interleukin 1 alpha	Homo sapiens	104-114
3545852-3	1987	Combined treatment with cycloheximide and actinomycin D also stimulates production and enhances production induced by IL 1 or poly(rI).poly(rC).	Dactinomycin	42-55	interleukin 1 alpha	Homo sapiens	118-122
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interleukin 1 alpha	Homo sapiens	64-74
2442110-4	1987	In contrast to these obviously inhibitory effects, CPH-86 (10(-7) M) alone induces IL-1 by human monocytes and, with mitogen, it induces IL-2 production by human lymphocytes.	Podophyllotoxin	51-57	interleukin 1 alpha	Homo sapiens	83-87
3494686-5	1987	Gel filtration chromatography on Sephadex G 150 revealed three distinct peaks of IL-1 activity, with apparent molecular weights of 14, 31 and 60 kilodaltons, respectively.	sephadex	33-47	interleukin 1 alpha	Homo sapiens	81-85
2431056-1	1987	Interleukin (IL 1) preparations from five different sources (human monocyte, LPS-stimulated, purified IL 1 from two different laboratories) and human recombinant IL 1 (HrIL 1) were shown to be capable of directly inducing histamine (HA) release from human basophils (10 to 50% of total cellular HA, depending on the source of IL 1).	Histamine	222-231	interleukin 1 alpha	Homo sapiens	13-17
2947968-1	1987	Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively.	Dinoprostone	49-65	interleukin 1 alpha	Homo sapiens	27-37
2947968-6	1987	Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion.	Dinoprostone	265-281	interleukin 1 alpha	Homo sapiens	77-87
2431056-1	1987	Interleukin (IL 1) preparations from five different sources (human monocyte, LPS-stimulated, purified IL 1 from two different laboratories) and human recombinant IL 1 (HrIL 1) were shown to be capable of directly inducing histamine (HA) release from human basophils (10 to 50% of total cellular HA, depending on the source of IL 1).	Histamine	222-231	interleukin 1 alpha	Homo sapiens	102-106
2431056-1	1987	Interleukin (IL 1) preparations from five different sources (human monocyte, LPS-stimulated, purified IL 1 from two different laboratories) and human recombinant IL 1 (HrIL 1) were shown to be capable of directly inducing histamine (HA) release from human basophils (10 to 50% of total cellular HA, depending on the source of IL 1).	Histamine	222-231	interleukin 1 alpha	Homo sapiens	102-106
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Bromodeoxyuridine	85-104	interleukin 1 alpha	Homo sapiens	116-129
2431056-1	1987	Interleukin (IL 1) preparations from five different sources (human monocyte, LPS-stimulated, purified IL 1 from two different laboratories) and human recombinant IL 1 (HrIL 1) were shown to be capable of directly inducing histamine (HA) release from human basophils (10 to 50% of total cellular HA, depending on the source of IL 1).	Histamine	222-231	interleukin 1 alpha	Homo sapiens	102-106
2433374-0	1987	Enhanced interleukin-1 production by human monocyte cell lines following treatment with 5-azacytidine.	Azacitidine	88-101	interleukin 1 alpha	Homo sapiens	9-22
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Bromodeoxyuridine	85-104	interleukin 1 alpha	Homo sapiens	131-135
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Bromodeoxyuridine	106-110	interleukin 1 alpha	Homo sapiens	116-129
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Bromodeoxyuridine	106-110	interleukin 1 alpha	Homo sapiens	131-135
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Azacitidine	61-74	interleukin 1 alpha	Homo sapiens	116-129
2433374-4	1987	Following treatment with AZA, U937.1 cells could be induced to produce IL-1 beta mRNA and release IL-1, but only if a stimulus such as LPS was present.	Azacitidine	25-28	interleukin 1 alpha	Homo sapiens	71-75
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Azacitidine	61-74	interleukin 1 alpha	Homo sapiens	131-135
2433374-5	1987	In addition, the level of IL-1 beta mRNA produced and IL-1 released by THP-1 cells after induction could be doubled by treatment with AZA.	Azacitidine	134-137	interleukin 1 alpha	Homo sapiens	26-30
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Azacitidine	76-79	interleukin 1 alpha	Homo sapiens	116-129
2433374-2	1987	We chose to examine the effects of two DNA modifying agents, 5-azacytidine (AZA) and 5-bromodeoxyuridine (BUdR), on interleukin-1 (IL-1) gene expression in the human monocyte cell lines THP-1 and U937.1.	Azacitidine	76-79	interleukin 1 alpha	Homo sapiens	131-135
3496463-7	1987	Brain IL-1, as well as authentic monocyte IL-1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture.	Thymidine	94-103	interleukin 1 alpha	Homo sapiens	6-10
3496463-7	1987	Brain IL-1, as well as authentic monocyte IL-1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture.	Thymidine	94-103	interleukin 1 alpha	Homo sapiens	42-46
3502482-0	1987	Effect of histamine and antihistamines on interleukin-1 production by human monocytes.	Histamine	10-19	interleukin 1 alpha	Homo sapiens	42-55
3502482-1	1987	This study was carried out on the effect of histamine hydrochloride and its antagonists on the production of interleukin-1 (IL-1) by lipopolysaccharide (LPS)-stimulated adherent human monocytes (AHM) from normal healthy blood donors.	Histamine	44-67	interleukin 1 alpha	Homo sapiens	109-128
3502482-3	1987	The result indicated that histamine hydrochloride significantly suppressed IL-1 production by AHM at 10(-3) M and 10(-10) M in 14 donors with maximal suppression observed at 10(-3) M. A 1-hr incubation with histamine hydrochloride (10(-3) M) before addition of LPS was found to be appropriate.	Histamine	26-49	interleukin 1 alpha	Homo sapiens	75-79
3331847-10	1987	At local sites of chronic inflammation concentrations of 1,25-(OH)2D3 may be elevated and may act in an autocrine or paracrine fashion to alter the immune response, for example, by increasing IL 1 production and antigen presentation by tissue monocyte/macrophages.	Calcitriol	57-69	interleukin 1 alpha	Homo sapiens	192-196
3502509-3	1987	IL-1 induces synthesis of prostacyclin, platelet activating factor, thromboplastin and plasminogen activator inhibitor.	Epoprostenol	26-38	interleukin 1 alpha	Homo sapiens	0-4
3031841-0	1986	Interleukin 1 stimulates endothelial cell tissue factor production and expression by a prostaglandin-independent mechanism.	Prostaglandins	87-100	interleukin 1 alpha	Homo sapiens	0-13
3120294-9	1987	Both interleukin-1 and interferon-gamma modulate release of arachidonate metabolites in various cells.	Arachidonic Acid	60-72	interleukin 1 alpha	Homo sapiens	5-39
2947813-2	1986	We have used oligonucleotide-directed mutagenesis to construct mutant human IL-1 proteins.	Oligonucleotides	13-28	interleukin 1 alpha	Homo sapiens	76-80
2947813-3	1986	Three different point mutants in a unique histidine residue (position 30) exhibited varying degrees of reduced IL-1 receptor binding affinity, whereas point mutants at five other residues behaved normally.	Histidine	42-51	interleukin 1 alpha	Homo sapiens	111-115
2947813-5	1986	These data suggest that the unique histidine residue influences the architecture of the receptor binding site on human IL-1.	Histidine	35-44	interleukin 1 alpha	Homo sapiens	119-123
3031841-6	1986	Endothelial cell procoagulant production and expression in response to interleukin 1 could be dissociated from endogenous prostaglandin metabolism, being insensitive to hydrocortisone, indomethacin, eicosatetrayionic acid and exogenous arachidonic acid.	Arachidonic Acid	236-252	interleukin 1 alpha	Homo sapiens	71-84
3031841-8	1986	We therefore conclude that interleukin 1 stimulates endothelial synthesis and surface expression of tissue factor by a prostaglandin-independent mechanism.	Prostaglandins	119-132	interleukin 1 alpha	Homo sapiens	27-40
3536222-3	1986	Human IL-1 and the P388D1 supernatants enhanced glycosaminoglycan (GAG) release from bovine nasal cartilage explants.	Glycosaminoglycans	48-65	interleukin 1 alpha	Homo sapiens	6-10
3535928-8	1986	These results indicate that IL-1 induces release of granulocyte-macrophage colony-stimulating activity (GM-CSA) from human mononuclear phagocytes.	gm-csa	104-110	interleukin 1 alpha	Homo sapiens	28-32
3536222-3	1986	Human IL-1 and the P388D1 supernatants enhanced glycosaminoglycan (GAG) release from bovine nasal cartilage explants.	Glycosaminoglycans	67-70	interleukin 1 alpha	Homo sapiens	6-10
3021848-0	1986	Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.	Prostaglandins	0-14	interleukin 1 alpha	Homo sapiens	68-81
3491091-7	1986	Interleukin-1 alpha mRNA was detected when SMC were incubated with endotoxin under "superinduction" conditions with cycloheximide.	Cycloheximide	116-129	interleukin 1 alpha	Homo sapiens	0-19
3492202-0	1986	Recombinant human interleukin 1 alpha and beta stimulate mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2.	Dinoprostone	150-166	interleukin 1 alpha	Homo sapiens	18-37
3492202-2	1986	Recombinant human interleukin 1 alpha (rhIL-1 alpha) and beta (rhIL-1 beta) stimulated PGE2 production in MC3T3-E1 cells in a dose dependent manner.	Dinoprostone	87-91	interleukin 1 alpha	Homo sapiens	18-37
3021848-0	1986	Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.	Cyclic AMP	119-149	interleukin 1 alpha	Homo sapiens	68-81
3502482-5	1987	Histamine hydrochloride (10(-3) M) added alone had no significant suppressive effect, while cimetidine (10(-5) M) alone had a significant stimulatory effect on IL-1 production by AHM.	Cimetidine	92-102	interleukin 1 alpha	Homo sapiens	160-164
3021848-2	1986	After in vitro stimulation by bacteriotoxins, monocytes express IL 1 activity, as measured by the thymocyte costimulation assay.	bacteriotoxins	30-44	interleukin 1 alpha	Homo sapiens	64-68
3021848-3	1986	Although high doses of bacteriotoxins impaired expression of IL 1, this effect was reversed by indomethacin.	bacteriotoxins	23-37	interleukin 1 alpha	Homo sapiens	61-65
3021848-3	1986	Although high doses of bacteriotoxins impaired expression of IL 1, this effect was reversed by indomethacin.	Indomethacin	95-107	interleukin 1 alpha	Homo sapiens	61-65
3021848-4	1986	When stimulated monocytes were cultured with exogenous prostaglandins, including PGE2 and PGI2, expression of IL 1 was reversibly inhibited.	Prostaglandins	55-69	interleukin 1 alpha	Homo sapiens	110-114
3021848-4	1986	When stimulated monocytes were cultured with exogenous prostaglandins, including PGE2 and PGI2, expression of IL 1 was reversibly inhibited.	Dinoprostone	81-85	interleukin 1 alpha	Homo sapiens	110-114
3021848-4	1986	When stimulated monocytes were cultured with exogenous prostaglandins, including PGE2 and PGI2, expression of IL 1 was reversibly inhibited.	Epoprostenol	90-94	interleukin 1 alpha	Homo sapiens	110-114
3021848-6	1986	Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes.	Cyclic AMP	58-62	interleukin 1 alpha	Homo sapiens	184-188
3021848-6	1986	Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes.	Theophylline	74-86	interleukin 1 alpha	Homo sapiens	184-188
3021848-6	1986	Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes.	1-Methyl-3-isobutylxanthine	88-110	interleukin 1 alpha	Homo sapiens	184-188
3021848-6	1986	Other agents that cause an increase in levels of cellular cAMP, including theophylline, isobutylmethylxanthine, dibutyryl cAMP, or cholera toxin, also reversibly reduced expression of IL 1 by stimulated monocytes.	Cyclic AMP	122-126	interleukin 1 alpha	Homo sapiens	184-188
3021848-10	1986	IL 1 stimulates synthesis of prostaglandins that reach high levels during immune and inflammatory reactions.	Prostaglandins	29-43	interleukin 1 alpha	Homo sapiens	0-4
3021848-11	1986	Our data suggest that prostaglandins participate in an autoregulatory pathway that posttranscriptionally reduces expression of IL 1 activity.	Prostaglandins	22-36	interleukin 1 alpha	Homo sapiens	127-131
3490850-1	1986	When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts.	Hyaluronic Acid	86-101	interleukin 1 alpha	Homo sapiens	150-154
2876960-5	1986	Crude lipid A from E. coli and N. meningitidis were both IL-1 inducers.	Lipid A	6-13	interleukin 1 alpha	Homo sapiens	57-61
3490494-4	1986	Purified native IL-1 and recombinant IL-1 stimulated endothelial cells to release CSA.	Cyclosporine	82-85	interleukin 1 alpha	Homo sapiens	16-20
3490494-4	1986	Purified native IL-1 and recombinant IL-1 stimulated endothelial cells to release CSA.	Cyclosporine	82-85	interleukin 1 alpha	Homo sapiens	37-41
3490494-7	1986	We conclude that IL-1 induces the release of CSA by vascular endothelial cells, that IL-1 is constitutively produced by monocytes in vitro, and that MRA and IL-1 are biologically, biophysically and, immunologically identical.	Cyclosporine	45-48	interleukin 1 alpha	Homo sapiens	17-21
3491062-9	1986	IL-1 secretion by monocytes was increased up to 48 +/- 18% (P less than 0.01) by addition of physiological concentrations of epinephrine in vitro.	Epinephrine	125-136	interleukin 1 alpha	Homo sapiens	0-4
3491062-10	1986	Low concentrations of hydrocortisone (1 ng/ml) also augmented IL-1 secretion by 58 +/- 20%.	Hydrocortisone	22-36	interleukin 1 alpha	Homo sapiens	62-66
3491062-11	1986	Higher concentrations in the physiological range had no effect, and combinations of epinephrine and hydrocortisone suppressed IL-1 secretion.	Epinephrine	84-95	interleukin 1 alpha	Homo sapiens	126-130
3491062-11	1986	Higher concentrations in the physiological range had no effect, and combinations of epinephrine and hydrocortisone suppressed IL-1 secretion.	Hydrocortisone	100-114	interleukin 1 alpha	Homo sapiens	126-130
3103171-0	1986	Stimulation of arachidonic acid metabolism: differences in potencies of recombinant human interleukin-1 alpha and interleukin-1 beta on two cell types.	Arachidonic Acid	15-31	interleukin 1 alpha	Homo sapiens	90-109
3103171-2	1986	Recombinant IL-1 alpha was 3 times more effective than rIL-1 beta at stimulating arachidonic acid metabolism by the primate smooth muscle cells.	Arachidonic Acid	81-97	interleukin 1 alpha	Homo sapiens	12-22
3490850-0	1986	Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	44-57
3490850-1	1986	When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts.	Hyaluronic Acid	86-101	interleukin 1 alpha	Homo sapiens	135-148
3490850-2	1986	A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing activity.	Hyaluronic Acid	15-30	interleukin 1 alpha	Homo sapiens	73-77
3490850-4	1986	Hyaluronic acid also stimulated human polymorphonuclear leucocytes to produce IL-1 like activity.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	78-82
3490850-5	1986	These results indicate that hyaluronic acid is an endogenous IL-1 inducer and may play important roles in the pathological and/or physiological changes of connective tissues.	Hyaluronic Acid	28-43	interleukin 1 alpha	Homo sapiens	61-65
3093048-3	1986	In some cancer patients with weight loss there are many similarities to an interleukin-1 response including increases in resting energy expenditure, whole-body protein flux and synthesis and glucose flux and recycling, hypoalbuminemia and increased albumin catabolic rates, and an adaptive low T3 state that suggest a similar injury/infection response.	Glucose	191-198	interleukin 1 alpha	Homo sapiens	75-88
3490846-1	1986	Effects of human recombinant interleukin 1 (IL-1) on the synthesis of glycosaminoglycan were examined with cultured rat costal chondrocytes.	Glycosaminoglycans	70-87	interleukin 1 alpha	Homo sapiens	29-48
3490846-2	1986	Incorporation of [35S]sulfate into glycosaminoglycan was strikingly diminished by the addition of IL-1 in a dose- and time- dependent manner.	Sulfur-35	18-21	interleukin 1 alpha	Homo sapiens	98-102
3492206-4	1986	Since a stimulation of prostaglandin E2 secretion was also observed in presence of Il-1, we investigated the eventual role of arachidonic acid metabolites in the phenomenon.	Dinoprostone	23-39	interleukin 1 alpha	Homo sapiens	83-87
3490846-2	1986	Incorporation of [35S]sulfate into glycosaminoglycan was strikingly diminished by the addition of IL-1 in a dose- and time- dependent manner.	Sulfates	22-29	interleukin 1 alpha	Homo sapiens	98-102
3490846-2	1986	Incorporation of [35S]sulfate into glycosaminoglycan was strikingly diminished by the addition of IL-1 in a dose- and time- dependent manner.	Glycosaminoglycans	35-52	interleukin 1 alpha	Homo sapiens	98-102
3490846-3	1986	When the cells were cultured with 340 micrograms/ml of IL-1 for 72 hr, the synthesis of glycosaminoglycan was inhibited to 10% of the control.	Glycosaminoglycans	88-105	interleukin 1 alpha	Homo sapiens	55-59
3493347-4	1986	A variable effect of piroxicam was observed on IL-1 and IL-2 generation despite the efficacy of piroxicam in reducing the clinical activity of the disease.	Piroxicam	21-30	interleukin 1 alpha	Homo sapiens	47-51
3489519-3	1986	Blood monocytes separated by centrifugal elutriation did not release IL-1 into the culture supernatant but elaborated IL-1 maximally within 24 h after treatment with lipopolysaccharide or desmethyl muramyl dipeptide.	N-acetyl-demethylmuramyl-alanyl-isoglutamine	188-215	interleukin 1 alpha	Homo sapiens	118-122
3489643-2	1986	Both synthetic muramyl dipeptide (MDP) and naturally occurring sleep factor (SF), which contains an MP structure, stimulate human monocytes to produce interleukin 1 (IL 1).	Acetylmuramyl-Alanyl-Isoglutamine	15-32	interleukin 1 alpha	Homo sapiens	151-170
3490388-0	1986	Induction of human interleukin 1 by bacterial and synthetic lipid A.	Lipid A	60-67	interleukin 1 alpha	Homo sapiens	19-32
3490388-2	1986	Here we show that synthetic heptaacyl Salmonella minnesota (compound 516) and synthetic E. coli type (compound 506) lipid A, as well as monodephospho part structures thereof, are able to induce IL 1 production in human mononuclear cells.	Lipid A	116-123	interleukin 1 alpha	Homo sapiens	194-198
3490458-1	1986	Human alveolar macrophages obtained from 7 normal volunteers and 7 patients with lung disease were stimulated with endotoxin (lipolysaccharide) to induce interleukin 1/leucocytic pyrogen (IL1/LP) secretion.	lipolysaccharide	126-142	interleukin 1 alpha	Homo sapiens	188-194
2429849-9	1986	In addition human interleukin-1 when tested in dexamethasone-treated test rats failed to induce neutrophil migration.	Dexamethasone	47-60	interleukin 1 alpha	Homo sapiens	18-31
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	Arginine	96-99	interleukin 1 alpha	Homo sapiens	0-13
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	Arginine	96-99	interleukin 1 alpha	Homo sapiens	15-19
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	Leukotrienes	101-112	interleukin 1 alpha	Homo sapiens	0-13
3019358-5	1986	These results suggest that the IL-1 induction of synovial cell PA occurs via generation of endogenous PGE2 and cAMP.	Cyclic AMP	111-115	interleukin 1 alpha	Homo sapiens	31-35
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	leucyl-phenylalanine	127-134	interleukin 1 alpha	Homo sapiens	0-13
3488955-3	1986	On polyacrylamide gel electrophoresis in Tris-glycinate buffer the IL-1-like factor of DCH-5 cells was heterogeneous and its components were more negatively charged than components of macrophage-derived IL-1.	polyacrylamide	3-17	interleukin 1 alpha	Homo sapiens	67-71
3019358-0	1986	Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP.	Dinoprostone	93-109	interleukin 1 alpha	Homo sapiens	14-27
3019358-0	1986	Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP.	Cyclic AMP	114-118	interleukin 1 alpha	Homo sapiens	14-27
3019358-1	1986	Addition of the cyclooxygenase inhibitor indomethacin to human synovial cells in culture, at concentrations which completely block prostaglandin E2 (PGE2) synthesis, reversibly inhibited the interleukin-1 (IL-1) stimulation of cell-associated and extracellular plasminogen activator (PA) production.	Indomethacin	41-53	interleukin 1 alpha	Homo sapiens	191-204
3019358-1	1986	Addition of the cyclooxygenase inhibitor indomethacin to human synovial cells in culture, at concentrations which completely block prostaglandin E2 (PGE2) synthesis, reversibly inhibited the interleukin-1 (IL-1) stimulation of cell-associated and extracellular plasminogen activator (PA) production.	Indomethacin	41-53	interleukin 1 alpha	Homo sapiens	206-210
3019358-1	1986	Addition of the cyclooxygenase inhibitor indomethacin to human synovial cells in culture, at concentrations which completely block prostaglandin E2 (PGE2) synthesis, reversibly inhibited the interleukin-1 (IL-1) stimulation of cell-associated and extracellular plasminogen activator (PA) production.	Dinoprostone	149-153	interleukin 1 alpha	Homo sapiens	191-204
3019358-4	1986	Addition of the phosphodiesterase inhibitor, theophylline, the adenylate cyclase stimulator, forskolin, or dibutyryl cAMP caused an enhancement of the IL-1 induction of synovial cell PA.	Theophylline	45-57	interleukin 1 alpha	Homo sapiens	151-155
3019358-4	1986	Addition of the phosphodiesterase inhibitor, theophylline, the adenylate cyclase stimulator, forskolin, or dibutyryl cAMP caused an enhancement of the IL-1 induction of synovial cell PA.	Colforsin	93-102	interleukin 1 alpha	Homo sapiens	151-155
3019358-4	1986	Addition of the phosphodiesterase inhibitor, theophylline, the adenylate cyclase stimulator, forskolin, or dibutyryl cAMP caused an enhancement of the IL-1 induction of synovial cell PA.	Bucladesine	107-121	interleukin 1 alpha	Homo sapiens	151-155
3019358-5	1986	These results suggest that the IL-1 induction of synovial cell PA occurs via generation of endogenous PGE2 and cAMP.	Dinoprostone	102-106	interleukin 1 alpha	Homo sapiens	31-35
2948903-7	1986	Analysis of the phosphoamino acid composition revealed that IL 1 induced specifically the phosphorylation of tyrosine residues of the 41 kDa protein.	Phosphoamino Acids	16-33	interleukin 1 alpha	Homo sapiens	60-64
2948903-7	1986	Analysis of the phosphoamino acid composition revealed that IL 1 induced specifically the phosphorylation of tyrosine residues of the 41 kDa protein.	Tyrosine	109-117	interleukin 1 alpha	Homo sapiens	60-64
3488955-3	1986	On polyacrylamide gel electrophoresis in Tris-glycinate buffer the IL-1-like factor of DCH-5 cells was heterogeneous and its components were more negatively charged than components of macrophage-derived IL-1.	tris-glycinate	41-55	interleukin 1 alpha	Homo sapiens	67-71
3488955-6	1986	Gel filtration showed that in PBS the IL-1-like factor of DCH-5 cells was partially aggregated.	Lead	30-33	interleukin 1 alpha	Homo sapiens	38-42
3492432-5	1986	Similar doses of recombinant IL 1 alpha exhibited inhibitory effects on the ornithine decarboxylase (ODC) activity of A375 cells by 6-24 h. Putrescine, a nontoxic product of the ODC pathway, could prevent the cytostatic effect of recombinant IL 1 alpha on these tumor target cells.	Putrescine	140-150	interleukin 1 alpha	Homo sapiens	29-39
3492432-5	1986	Similar doses of recombinant IL 1 alpha exhibited inhibitory effects on the ornithine decarboxylase (ODC) activity of A375 cells by 6-24 h. Putrescine, a nontoxic product of the ODC pathway, could prevent the cytostatic effect of recombinant IL 1 alpha on these tumor target cells.	Putrescine	140-150	interleukin 1 alpha	Homo sapiens	242-252
3526909-4	1986	IL-1 alpha mRNA was also detected when endothelial cells were exposed to endotoxin under "superinduction" conditions in the presence of cycloheximide.	Cycloheximide	136-149	interleukin 1 alpha	Homo sapiens	0-10
3091636-6	1986	Fractionation of SFMC supernatants on phosphocellulose columns revealed the presence of IL-1 and a potent IL-1 inhibitor.	phosphocellulose	38-54	interleukin 1 alpha	Homo sapiens	88-92
3091636-8	1986	These results suggest that IL-1 inhibitor(s) in SFMC impair(s) OKT3-induced mitogenesis by interfering with the effects of IL-1 on T lymphocytes.	sfmc	48-52	interleukin 1 alpha	Homo sapiens	27-31
3527721-0	1986	Inhibition of lipopolysaccharide-induced monocyte interleukin 1 secretion by gangliosides.	Gangliosides	77-89	interleukin 1 alpha	Homo sapiens	50-63
3527721-1	1986	Gangliosides known to be potent immunosuppressors are shown to inhibit the secretion of interleukin 1 (IL 1) by human monocytes stimulated with lipopolysaccharide (LPS).	Gangliosides	0-12	interleukin 1 alpha	Homo sapiens	88-107
3527721-3	1986	The inhibition of LPS-induced IL 1 secretion was obtained in the presence of indomethacin, indicating that the ganglioside inhibitory capacity was not due to prostaglandin induction.	Indomethacin	77-89	interleukin 1 alpha	Homo sapiens	30-34
3527721-3	1986	The inhibition of LPS-induced IL 1 secretion was obtained in the presence of indomethacin, indicating that the ganglioside inhibitory capacity was not due to prostaglandin induction.	Gangliosides	111-122	interleukin 1 alpha	Homo sapiens	30-34
3488232-4	1986	In contrast, alkaline phosphatase activity was enhanced significantly by IL-1 in the cell line cultivated in 1% FCS-containing alpha-MEM.	alpha-mem	127-136	interleukin 1 alpha	Homo sapiens	73-77
3488738-0	1986	Stimulation of prostaglandin E2 and bone resorption by recombinant human interleukin 1 alpha in fetal mouse bones.	Dinoprostone	15-31	interleukin 1 alpha	Homo sapiens	73-92
3488738-1	1986	Recombinant human interleukin 1 alpha (rhIL-1 alpha) stimulates prostaglandin E2 and bone resorption in cultured forearm bones of fetal mouse in a dose-dependent manner: the minimal rhIL-1 alpha to elicit a significant bone resorption was 1.6 ng/ml (89 pM).	Dinoprostone	64-80	interleukin 1 alpha	Homo sapiens	18-37
3488738-3	1986	The bone resorbing activity induced by IL-1 was partially inhibited by indomethacin and hydrocortisone, and completely inhibited by anti-IL 1-antibody.	Indomethacin	71-83	interleukin 1 alpha	Homo sapiens	39-43
3488738-3	1986	The bone resorbing activity induced by IL-1 was partially inhibited by indomethacin and hydrocortisone, and completely inhibited by anti-IL 1-antibody.	Hydrocortisone	88-102	interleukin 1 alpha	Homo sapiens	39-43
3488738-4	1986	There was a good correlation between PGE2 production and bone resorption induced by IL-1 alpha.	Dinoprostone	37-41	interleukin 1 alpha	Homo sapiens	84-94
3487789-5	1986	These results permit mapping the active site of IL-1 to a peptide of 6970 molecular weight located within the carboxyl third (between Met-136 and Gln-197) of the IL-1 precursor.	Methionine	134-137	interleukin 1 alpha	Homo sapiens	48-52
3486911-8	1986	Hybridization of cytoplasmic RNA with an oligonucleotide probe for human IL 1-alpha confirmed the T cell source of the biological activity.	Oligonucleotides	41-56	interleukin 1 alpha	Homo sapiens	73-83
3487789-5	1986	These results permit mapping the active site of IL-1 to a peptide of 6970 molecular weight located within the carboxyl third (between Met-136 and Gln-197) of the IL-1 precursor.	Methionine	134-137	interleukin 1 alpha	Homo sapiens	162-166
3487789-5	1986	These results permit mapping the active site of IL-1 to a peptide of 6970 molecular weight located within the carboxyl third (between Met-136 and Gln-197) of the IL-1 precursor.	Glutamine	146-149	interleukin 1 alpha	Homo sapiens	48-52
3487789-5	1986	These results permit mapping the active site of IL-1 to a peptide of 6970 molecular weight located within the carboxyl third (between Met-136 and Gln-197) of the IL-1 precursor.	Glutamine	146-149	interleukin 1 alpha	Homo sapiens	162-166
3489956-0	1986	In vitro enhanced thromboxane B2 release by polymorphonuclear leukocytes and macrophages after treatment with human recombinant interleukin 1.	Thromboxane B2	18-32	interleukin 1 alpha	Homo sapiens	128-141
3489956-2	1986	We examined the ability of rat peritoneal macrophages and human PMNs to synthesize thromboxane A2 (detected as TxB2) in response to human recombinant interleukin 1 (hrIL1).	Thromboxane A2	83-97	interleukin 1 alpha	Homo sapiens	150-163
3491023-4	1986	Both DON and AcDON were shown to induce interleukin 1 (IL-1) release in peritoneal macrophages by a mode of action similar to that of cycloheximide.	deoxynivalenol	5-8	interleukin 1 alpha	Homo sapiens	55-59
3086977-4	1986	The islet-inhibitory activity and the IL-1 activity (determined by its comitogenic effect on thymocytes) were recovered by acid wash.	acid wash	123-132	interleukin 1 alpha	Homo sapiens	38-42
3491698-3	1986	The presence of cytochalasin B enhanced LPS-induced IL-1 secretion without altering IL-1 synthesis.	Cytochalasin B	16-30	interleukin 1 alpha	Homo sapiens	52-56
3491698-4	1986	Monocytes preincubated in dexamethasone or hydrocortisone failed to exhibit any IL-1 activity in supernatants after LPS stimulation but the cell lysates still possessed 50% of control IL-1 activity.	Dexamethasone	26-39	interleukin 1 alpha	Homo sapiens	184-188
3491698-5	1986	Studies with different LPS preparations indicated that the presence of diphosphoryl groups in lipid A enhanced the IL-1-inducing activities.	diphosphoryl	71-83	interleukin 1 alpha	Homo sapiens	115-119
3491698-5	1986	Studies with different LPS preparations indicated that the presence of diphosphoryl groups in lipid A enhanced the IL-1-inducing activities.	Lipid A	94-101	interleukin 1 alpha	Homo sapiens	115-119
3491023-4	1986	Both DON and AcDON were shown to induce interleukin 1 (IL-1) release in peritoneal macrophages by a mode of action similar to that of cycloheximide.	acetyldeoxynivalenol	13-18	interleukin 1 alpha	Homo sapiens	55-59
3491023-5	1986	In the presence of DON, cellular IL-1 did not decay, and this resulted in a marked release of IL-1 from the cell during the period of exposure to the inhibitor.	deoxynivalenol	19-22	interleukin 1 alpha	Homo sapiens	33-37
3491023-5	1986	In the presence of DON, cellular IL-1 did not decay, and this resulted in a marked release of IL-1 from the cell during the period of exposure to the inhibitor.	deoxynivalenol	19-22	interleukin 1 alpha	Homo sapiens	94-98
3486886-3	1986	In this study we have identified interleukin 1 (IL-1) as a monokine that stimulates fibroblasts to produce and release GM-CSA and prostaglandin E2 (PGE2).	gm-csa	119-125	interleukin 1 alpha	Homo sapiens	33-52
2872233-5	1986	To study the mechanism of IL-1-induced HEC-PAF production we tested the activity of 1-O-alkyl-sn-glycero-3-phosphocholine:acetyl/coenzyme A acetyltransferase in HEC.	1-o-alkyl-sn-glycero-3-phosphocholine	84-121	interleukin 1 alpha	Homo sapiens	26-30
3486886-3	1986	In this study we have identified interleukin 1 (IL-1) as a monokine that stimulates fibroblasts to produce and release GM-CSA and prostaglandin E2 (PGE2).	Dinoprostone	130-146	interleukin 1 alpha	Homo sapiens	33-52
3486886-3	1986	In this study we have identified interleukin 1 (IL-1) as a monokine that stimulates fibroblasts to produce and release GM-CSA and prostaglandin E2 (PGE2).	Dinoprostone	148-152	interleukin 1 alpha	Homo sapiens	33-52
3486886-4	1986	Both purified human monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production.	gm-csa	158-164	interleukin 1 alpha	Homo sapiens	37-41
3486886-4	1986	Both purified human monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production.	gm-csa	158-164	interleukin 1 alpha	Homo sapiens	64-68
3486886-4	1986	Both purified human monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production.	Dinoprostone	169-173	interleukin 1 alpha	Homo sapiens	37-41
3486886-4	1986	Both purified human monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production.	Dinoprostone	169-173	interleukin 1 alpha	Homo sapiens	64-68
3486886-5	1986	Both forms of IL-1 stimulate fibroblasts to produce GM-CSA and PGE2 in a dose-dependent fashion.	gm-csa	52-58	interleukin 1 alpha	Homo sapiens	14-18
3486886-5	1986	Both forms of IL-1 stimulate fibroblasts to produce GM-CSA and PGE2 in a dose-dependent fashion.	Dinoprostone	63-67	interleukin 1 alpha	Homo sapiens	14-18
3486886-7	1986	We conclude that monocytes produce IL-1, and that monocyte-derived IL-1 induces fibroblasts to produce GM-CSA and PGE2.	gm-csa	103-109	interleukin 1 alpha	Homo sapiens	67-71
3486886-7	1986	We conclude that monocytes produce IL-1, and that monocyte-derived IL-1 induces fibroblasts to produce GM-CSA and PGE2.	Dinoprostone	114-118	interleukin 1 alpha	Homo sapiens	67-71
3488401-3	1986	Both of these areas of activity also stimulate prostaglandin (PGE) from adherent synovial cells and have interleukin 1 (IL-1) activity.	Prostaglandins	47-60	interleukin 1 alpha	Homo sapiens	105-124
3091790-8	1986	It is now clear that interleukin-1 has multiple actions on both immune and non-immune cells; these include the induction of lymphocyte differentiation and proliferation and the stimulation of bone and cartilage resorption, and prostaglandin and metalloproteinase synthesis by connective tissues.	Prostaglandins	227-240	interleukin 1 alpha	Homo sapiens	21-34
3485687-5	1986	IL 1 activity was eluted from the column at high acetonitrile concentration.	acetonitrile	49-61	interleukin 1 alpha	Homo sapiens	0-4
3485687-6	1986	Subsequent chromatography over hydroxyapatite yielded a single IL 1 species with a pI of 5.5.	Durapatite	31-45	interleukin 1 alpha	Homo sapiens	63-67
3489547-0	1986	Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production.	Calcitriol	24-48	interleukin 1 alpha	Homo sapiens	144-157
3489547-7	1986	In contrast to its effects on IL-2 production, 1,25-(OH)2D3 caused a dose-dependent increase in the production of interleukin-1 (IL-1) by monocyte/macrophages.	Calcitriol	47-59	interleukin 1 alpha	Homo sapiens	114-133
3486814-5	1986	This could be demonstrated by incubating the plasma membranes in the presence of IL 1 and (gamma-32P)-ATP, separating the proteins by SDS-PAGE and subsequent autoradiography.	Sodium Dodecyl Sulfate	134-137	interleukin 1 alpha	Homo sapiens	81-85
3486459-11	1986	Thus, the inhibitory action of GC on thymocyte mitogenesis cannot be explained only by the steroid-induced inhibition of IL-1--IL-2 production; it must also be due to a GC-inhibitory effect on the IL-2-responsive cell proliferation.	Steroids	91-98	interleukin 1 alpha	Homo sapiens	121-125
3514458-3	1986	However, only in patients with lepromatous leprosy, M. leprae, but not BCG, induced high-level synthesis of prostaglandin E2, which acted as a suppressor factor in the mouse thymocyte proliferative assay used to measure the interleukin-1 content of the supernatants.	Dinoprostone	108-124	interleukin 1 alpha	Homo sapiens	224-237
3081573-9	1986	These data indicate that lung fibroblast replication in response to two of the primary growth promoting signals spontaneously released by alveolar macrophages in the interstitial lung disorders, while uninfluenced by IFN gamma, can be inhibited by PGE2 and modestly augmented by IL-1.	Dinoprostone	248-252	interleukin 1 alpha	Homo sapiens	279-283
3484681-1	1986	Growth inhibitors and interleukin-1 (IL-1) are two biological response modifiers produced by mezerein-treated THP-1 cells maintained in serum-free medium.	mezerein	93-101	interleukin 1 alpha	Homo sapiens	22-35
3484681-1	1986	Growth inhibitors and interleukin-1 (IL-1) are two biological response modifiers produced by mezerein-treated THP-1 cells maintained in serum-free medium.	mezerein	93-101	interleukin 1 alpha	Homo sapiens	37-41
3484681-4	1986	IL-1-containing fractions were further analyzed by chromatography with DEAE-Sephacel, phenyl:Sepharose, and concanavalin A:Sepharose.	deae-sephacel	71-84	interleukin 1 alpha	Homo sapiens	0-4
3484681-4	1986	IL-1-containing fractions were further analyzed by chromatography with DEAE-Sephacel, phenyl:Sepharose, and concanavalin A:Sepharose.	Sepharose	93-102	interleukin 1 alpha	Homo sapiens	0-4
3484681-4	1986	IL-1-containing fractions were further analyzed by chromatography with DEAE-Sephacel, phenyl:Sepharose, and concanavalin A:Sepharose.	Sepharose	123-132	interleukin 1 alpha	Homo sapiens	0-4
3484681-6	1986	IL-1 and growth-inhibitory activities partially purified by sequential isofocusing, AcA-54 chromatography, and DEAE-Sephacel were located in a single region following preparative polyacrylamide gel electrophoresis.	deae-sephacel	111-124	interleukin 1 alpha	Homo sapiens	0-4
3484681-6	1986	IL-1 and growth-inhibitory activities partially purified by sequential isofocusing, AcA-54 chromatography, and DEAE-Sephacel were located in a single region following preparative polyacrylamide gel electrophoresis.	polyacrylamide	179-193	interleukin 1 alpha	Homo sapiens	0-4
3484681-10	1986	DEAE-purified IL-1 derived from THP-1 cells inhibited the growth of 7 of 11 cell types tested, and all inhibited cell lines were established from malignant sources.	2-diethylaminoethanol	0-4	interleukin 1 alpha	Homo sapiens	14-18
3484681-11	1986	Prostaglandin synthesis by MCF-7 cells in response to IL-1 was not responsible for growth inhibition.	Prostaglandins	0-13	interleukin 1 alpha	Homo sapiens	54-58
3484767-3	1986	Addition of 5 U/ml of purified IL 1 to chondrocytes led to an early increase in cell-associated phospholipase A2 (PLA2; measured by hydrolysis of [14C]arachidonic acid-labeled E. coli).	Carbon-14	147-150	interleukin 1 alpha	Homo sapiens	31-35
3488619-1	1986	Effects of interleukin-1 on the release of prostaglandins.	Prostaglandins	43-57	interleukin 1 alpha	Homo sapiens	11-24
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Dinoprostone	46-50	interleukin 1 alpha	Homo sapiens	0-13
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Dinoprostone	46-50	interleukin 1 alpha	Homo sapiens	15-19
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Arachidonic Acid	229-245	interleukin 1 alpha	Homo sapiens	0-13
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Arachidonic Acid	229-245	interleukin 1 alpha	Homo sapiens	15-19
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Diglycerides	258-272	interleukin 1 alpha	Homo sapiens	0-13
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Diglycerides	258-272	interleukin 1 alpha	Homo sapiens	15-19
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Phospholipids	287-299	interleukin 1 alpha	Homo sapiens	0-13
3488619-2	1986	Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid.	Phospholipids	287-299	interleukin 1 alpha	Homo sapiens	15-19
3488619-3	1986	In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1.	Arachidonic Acid	105-121	interleukin 1 alpha	Homo sapiens	13-17
3488619-3	1986	In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1.	Arachidonic Acid	105-121	interleukin 1 alpha	Homo sapiens	183-187
3488619-3	1986	In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1.	Prostaglandins	127-141	interleukin 1 alpha	Homo sapiens	13-17
3488619-3	1986	In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1.	Prostaglandins	127-141	interleukin 1 alpha	Homo sapiens	183-187
3488619-4	1986	Evidence is also presented that fever is caused by interleukin-1-induced prostaglandin E2.	Dinoprostone	73-89	interleukin 1 alpha	Homo sapiens	51-64
3488622-10	1986	Moreover, natural killer cell activity in the presence of IL-1 or interferon-alpha is suppressed by incubating temperatures of 39 degrees C. This effect is not reversed by inhibitors of prostaglandin synthesis.	Prostaglandins	186-199	interleukin 1 alpha	Homo sapiens	58-62
3484767-3	1986	Addition of 5 U/ml of purified IL 1 to chondrocytes led to an early increase in cell-associated phospholipase A2 (PLA2; measured by hydrolysis of [14C]arachidonic acid-labeled E. coli).	Arachidonic Acid	151-167	interleukin 1 alpha	Homo sapiens	31-35
3484767-5	1986	IL 1 stimulation also led to a time- and dose-related release of extracellular PLA2 and PGE2, but IL 1-induced PLA2 and PGE2 secretion occurred after the initial burst of intracellular PLA2 activity.	Dinoprostone	88-92	interleukin 1 alpha	Homo sapiens	0-4
3484767-5	1986	IL 1 stimulation also led to a time- and dose-related release of extracellular PLA2 and PGE2, but IL 1-induced PLA2 and PGE2 secretion occurred after the initial burst of intracellular PLA2 activity.	Dinoprostone	120-124	interleukin 1 alpha	Homo sapiens	98-102
3003163-0	1986	Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.	Dinoprostone	59-75	interleukin 1 alpha	Homo sapiens	18-31
3487013-4	1986	IL-1 increases the concentration of metabolites of arachidonic acid, most notably PGE2, in brain, muscle, chondrocytes and synovial fibroblasts, and hence plays a role in local tissue inflammation and disease processes.	Arachidonic Acid	51-67	interleukin 1 alpha	Homo sapiens	0-4
3487013-4	1986	IL-1 increases the concentration of metabolites of arachidonic acid, most notably PGE2, in brain, muscle, chondrocytes and synovial fibroblasts, and hence plays a role in local tissue inflammation and disease processes.	Dinoprostone	82-86	interleukin 1 alpha	Homo sapiens	0-4
3487014-6	1986	The effects of CsA (1 ng/ml-1 microgram/ml) on T cell-independent production of IL1 by irradiated, carrageenan-stimulated peritoneal macrophages were also examined.	Carrageenan	99-110	interleukin 1 alpha	Homo sapiens	80-83
3485895-0	1986	Augmentation of thromboxane production in vitro by polymorphonuclears and macrophages exposed to IL1/LP.	Thromboxanes	16-27	interleukin 1 alpha	Homo sapiens	97-100
3485895-1	1986	Human peripheral blood polymorphonuclear leukocytes (PMNs) and murine peritoneal macrophages (M phi) were stimulated to generate thromboxane upon treatment with highly purified human interleukin 1/leukocytic pyrogen (IL1/LP) at various concentrations.	Thromboxanes	129-140	interleukin 1 alpha	Homo sapiens	217-223
3485895-2	1986	Thromboxane B2 was measured by radioimmunoassay in the cell-free supernatants of cell suspensions after 1 hour incubation at 37 degrees C. Thromboxane B2 amounts increased in a way which depended on the dose of IL1 added to the cell cultures.	Thromboxane B2	0-14	interleukin 1 alpha	Homo sapiens	211-214
3485895-2	1986	Thromboxane B2 was measured by radioimmunoassay in the cell-free supernatants of cell suspensions after 1 hour incubation at 37 degrees C. Thromboxane B2 amounts increased in a way which depended on the dose of IL1 added to the cell cultures.	Thromboxane B2	139-153	interleukin 1 alpha	Homo sapiens	211-214
3493868-6	1986	Inducers of IL-1 are present in dialysate and include bacterial pyrogen and acetate.	Acetates	76-83	interleukin 1 alpha	Homo sapiens	12-16
3493868-8	1986	Muramyl dipeptides have been found in CAPD drain fluid and are more potent inducers of IL-1 than endotoxin.	Dipeptides	8-18	interleukin 1 alpha	Homo sapiens	87-91
3000663-6	1986	Indeed, a supernatant from silica-treated human mononuclear cells containing IL-1 activity also enhanced cytotoxic and proliferative responses.	Silicon Dioxide	27-33	interleukin 1 alpha	Homo sapiens	77-81
2420732-1	1986	The interaction of human polymorphonuclear neutrophilic leukocytes (neutrophils) with interleukin-1 (IL-1) resulted in a time- and concentration-dependent, selective, release of azurophil (myeloperoxidase, lysozyme) and specific (lysozyme, vitamin B12-binding protein) granule constituents.	azurophil	178-187	interleukin 1 alpha	Homo sapiens	86-99
3514344-1	1986	Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets.	Glucose	143-150	interleukin 1 alpha	Homo sapiens	34-47
3514344-1	1986	Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets.	Glucagon	219-227	interleukin 1 alpha	Homo sapiens	34-47
3021852-11	1986	Finally, anti-Tp44 and IL 1 each augmented proliferation of phorbol ester-stimulated lymphocytes, whereas anti-CD5 did not.	Phorbol Esters	60-73	interleukin 1 alpha	Homo sapiens	23-27
3021852-12	1986	The effects of IL 1 and Tp44 could be further distinguished in that the effect of anti-Tp44 was resistant to inhibition by dBcAMP whereas IL 1 was not.	Bucladesine	123-129	interleukin 1 alpha	Homo sapiens	15-19
2427461-0	1986	Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS).	Inosine Pranobex	0-12	interleukin 1 alpha	Homo sapiens	24-37
2427461-1	1986	The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study.	Inosine Pranobex	24-36	interleukin 1 alpha	Homo sapiens	64-68
2420732-1	1986	The interaction of human polymorphonuclear neutrophilic leukocytes (neutrophils) with interleukin-1 (IL-1) resulted in a time- and concentration-dependent, selective, release of azurophil (myeloperoxidase, lysozyme) and specific (lysozyme, vitamin B12-binding protein) granule constituents.	azurophil	178-187	interleukin 1 alpha	Homo sapiens	101-105
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	Calcium	68-75	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	88-156	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	158-163	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	Trifluoperazine	191-206	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	Trifluoperazine	208-211	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	4,4"-diisothiocyano-2,2"-disulfonic acid stilbene	244-293	interleukin 1 alpha	Homo sapiens	0-4
2420732-4	1986	IL-1-elicited granule exocytosis was inhibited by the intracellular calcium antagonist, 8-(N,N-diethylamino)-octyl-(3,4,5-trimethoxy) benzoate hydrochloride (TMB-8), a calmodulin antagonist, trifluoperazine (TFP), and an anion channel blocker, 4,4"-diisothiocyano-2,2"-disulfonic acid stilbene (DIDS).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	295-299	interleukin 1 alpha	Homo sapiens	0-4
2940301-0	1986	Interleukin 1 and 2 production in homosexual men: a controlled trial of therafectin (SM-1213), a possible immunomodulator.	amiprilose	72-83	interleukin 1 alpha	Homo sapiens	0-19
2416819-8	1986	A protein synthesis inhibitor (cycloheximide) and an RNA synthesis inhibitor (actinomycin D) prevented the acquisition of adhesiveness stimulated by IL 1 and endotoxin but not by TPA.	Cycloheximide	31-44	interleukin 1 alpha	Homo sapiens	149-153
2940301-3	1986	Therafectin (SM-1213) is a new agent which selectively activates macrophages and stimulated interleukin 1 production in vitro.	amiprilose	0-11	interleukin 1 alpha	Homo sapiens	92-105
2416819-8	1986	A protein synthesis inhibitor (cycloheximide) and an RNA synthesis inhibitor (actinomycin D) prevented the acquisition of adhesiveness stimulated by IL 1 and endotoxin but not by TPA.	Dactinomycin	78-91	interleukin 1 alpha	Homo sapiens	149-153
2940301-3	1986	Therafectin (SM-1213) is a new agent which selectively activates macrophages and stimulated interleukin 1 production in vitro.	amiprilose	13-20	interleukin 1 alpha	Homo sapiens	92-105
3936658-6	1985	The positive therapeutic effect of gold sodium thiomalate therapy correlated with the normalization in the cell"s capacity to produce IL-1 and IL-2.	Gold Sodium Thiomalate	35-57	interleukin 1 alpha	Homo sapiens	134-138
3489274-0	1986	The effects of synovial fluid macrophages and interleukin-1 on hyaluronic acid synthesis by normal synovial fibroblasts.	Hyaluronic Acid	63-78	interleukin 1 alpha	Homo sapiens	46-59
3878084-6	1985	Cycloheximide and actinomycin D block these IL-1 actions on endothelium, which suggests the requirement for de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 alpha	Homo sapiens	44-48
3878084-6	1985	Cycloheximide and actinomycin D block these IL-1 actions on endothelium, which suggests the requirement for de novo protein synthesis.	Dactinomycin	18-31	interleukin 1 alpha	Homo sapiens	44-48
2999234-9	1985	These results indicate that leukotrienes can modulate IL 1 production by human monocytes and suggest that they may play a role in IL 1-mediated functions of monocytes in inflammatory and immune reactions.	Leukotrienes	28-40	interleukin 1 alpha	Homo sapiens	54-58
3877692-4	1985	The cultured cells generally produce less IL-1 than do monocytes, but considerably more IL-1 is induced from cells that have undergone a terminal differentiation as a result of exposure to 1 alpha,25-dihydroxyvitamin D3.	Calcitriol	189-219	interleukin 1 alpha	Homo sapiens	88-92
2999234-9	1985	These results indicate that leukotrienes can modulate IL 1 production by human monocytes and suggest that they may play a role in IL 1-mediated functions of monocytes in inflammatory and immune reactions.	Leukotrienes	28-40	interleukin 1 alpha	Homo sapiens	130-134
2933470-7	1985	These findings, together with the augmented production of interleukin-1-like activity by retinol-treated gingival organ cultures suggest that low doses of retinol may alter immune reactions within epithelia via stimulation of both keratinocytes and LC.	Vitamin A	89-96	interleukin 1 alpha	Homo sapiens	58-71
3930602-3	1985	SN containing 30 KD MF are inactive in the thymocyte co-stimulator assay, under conditions that will detect as little as 0.5 U of purified IL 1.	Tin	0-2	interleukin 1 alpha	Homo sapiens	139-143
2933470-7	1985	These findings, together with the augmented production of interleukin-1-like activity by retinol-treated gingival organ cultures suggest that low doses of retinol may alter immune reactions within epithelia via stimulation of both keratinocytes and LC.	Vitamin A	155-162	interleukin 1 alpha	Homo sapiens	58-71
2999234-0	1985	Leukotrienes augment interleukin 1 production by human monocytes.	Leukotrienes	0-12	interleukin 1 alpha	Homo sapiens	21-34
2999234-1	1985	The effects of leukotrienes (LT) on production of interleukin 1 (IL 1) by human peripheral blood monocytes were examined.	Leukotrienes	15-27	interleukin 1 alpha	Homo sapiens	50-69
2999234-2	1985	LTB4 enhanced IL 1 production by lipopolysaccharide (LPS)-stimulated monocytes twofold to threefold, and the most efficient concentrations of LTB4 were 10(-8) to 10(-7) M. LTD4 also enhanced IL 1 production, but to a lesser extent than LTB4.	Leukotriene B4	0-4	interleukin 1 alpha	Homo sapiens	14-18
2999234-2	1985	LTB4 enhanced IL 1 production by lipopolysaccharide (LPS)-stimulated monocytes twofold to threefold, and the most efficient concentrations of LTB4 were 10(-8) to 10(-7) M. LTD4 also enhanced IL 1 production, but to a lesser extent than LTB4.	Leukotriene B4	0-4	interleukin 1 alpha	Homo sapiens	191-195
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Acetylmuramyl-Alanyl-Isoglutamine	80-97	interleukin 1 alpha	Homo sapiens	11-15
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Acetylmuramyl-Alanyl-Isoglutamine	80-97	interleukin 1 alpha	Homo sapiens	66-70
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Silicon Dioxide	99-105	interleukin 1 alpha	Homo sapiens	11-15
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Silicon Dioxide	99-105	interleukin 1 alpha	Homo sapiens	66-70
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Zymosan	110-117	interleukin 1 alpha	Homo sapiens	11-15
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Zymosan	110-117	interleukin 1 alpha	Homo sapiens	66-70
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Leukotriene B4	139-143	interleukin 1 alpha	Homo sapiens	11-15
2999234-4	1985	Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4.	Leukotriene B4	139-143	interleukin 1 alpha	Homo sapiens	66-70
2999234-5	1985	Inhibition of cyclooxygenase with use of indomethacin during IL 1 production by LPS-treated monocytes enhanced thymocyte response to IL 1, but LTB4 further enhanced IL 1 production when added to indomethacin-treated monocyte cultures.	Indomethacin	41-53	interleukin 1 alpha	Homo sapiens	61-65
2999234-5	1985	Inhibition of cyclooxygenase with use of indomethacin during IL 1 production by LPS-treated monocytes enhanced thymocyte response to IL 1, but LTB4 further enhanced IL 1 production when added to indomethacin-treated monocyte cultures.	Indomethacin	41-53	interleukin 1 alpha	Homo sapiens	133-137
2999234-5	1985	Inhibition of cyclooxygenase with use of indomethacin during IL 1 production by LPS-treated monocytes enhanced thymocyte response to IL 1, but LTB4 further enhanced IL 1 production when added to indomethacin-treated monocyte cultures.	Indomethacin	41-53	interleukin 1 alpha	Homo sapiens	133-137
3879111-0	1985	Phorbol myristate acetate--fate and usability in a human interleukin-1 assay.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	57-70
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	64-77
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	79-83
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Homo sapiens	64-77
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Homo sapiens	79-83
3879111-2	1985	Supernatants from cultures of human Mo, stimulated with PMA, 2 X 10(-6) M, contained IL-1-like activity, as judged by their high co-mitogenic effect on mitogen-stimulated human T-cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 1 alpha	Homo sapiens	85-89
3879111-4	1985	By way of 3H-PMA it was demonstrated that the IL-1-like effect of PMA-induced supernatants was non-dialyzable, was coupled to proteins with a molecular weight greater than 70,000 Dalton and could be dependent mainly upon the PMA content.	3h-pma	10-16	interleukin 1 alpha	Homo sapiens	46-50
3879111-4	1985	By way of 3H-PMA it was demonstrated that the IL-1-like effect of PMA-induced supernatants was non-dialyzable, was coupled to proteins with a molecular weight greater than 70,000 Dalton and could be dependent mainly upon the PMA content.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	46-50
3879111-4	1985	By way of 3H-PMA it was demonstrated that the IL-1-like effect of PMA-induced supernatants was non-dialyzable, was coupled to proteins with a molecular weight greater than 70,000 Dalton and could be dependent mainly upon the PMA content.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 alpha	Homo sapiens	46-50
3877078-7	1985	IL-1 induction of endothelial adhesivity was concentration dependent (maximum, 10 U/ml), time dependent (peak, 4-6 h), and reversible, was blocked by cycloheximide (10 micrograms/ml) or actinomycin D (5 micrograms/ml) but not by acetylsalicylic acid (100 microM), and occurred without detectable endothelial cell damage.	Cycloheximide	150-163	interleukin 1 alpha	Homo sapiens	0-4
3877078-7	1985	IL-1 induction of endothelial adhesivity was concentration dependent (maximum, 10 U/ml), time dependent (peak, 4-6 h), and reversible, was blocked by cycloheximide (10 micrograms/ml) or actinomycin D (5 micrograms/ml) but not by acetylsalicylic acid (100 microM), and occurred without detectable endothelial cell damage.	Dactinomycin	186-199	interleukin 1 alpha	Homo sapiens	0-4
3877078-7	1985	IL-1 induction of endothelial adhesivity was concentration dependent (maximum, 10 U/ml), time dependent (peak, 4-6 h), and reversible, was blocked by cycloheximide (10 micrograms/ml) or actinomycin D (5 micrograms/ml) but not by acetylsalicylic acid (100 microM), and occurred without detectable endothelial cell damage.	Aspirin	229-249	interleukin 1 alpha	Homo sapiens	0-4
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	41-45
2996929-5	1985	Thus, mononuclear cell factor, homologous with interleukin 1, partially purified from monocyte conditioned medium increased incorporation of [35S]methionine into several medium proteins, including those complexed by the anticollagenase antibody.	[35s]methionine	141-156	interleukin 1 alpha	Homo sapiens	47-60
2416045-3	1985	However, it has been shown that IL-1 also induces release of collagenase and prostaglandins by fibroblasts.	Prostaglandins	77-91	interleukin 1 alpha	Homo sapiens	32-36
2416045-4	1985	Furthermore, injections of IL-1 into animals are followed by fever, leukocytosis, increased serum concentrations of fibrinogen, serum amyloid A and haptoglobin, and decreased levels of iron and zinc.	Iron	185-189	interleukin 1 alpha	Homo sapiens	27-31
3875392-5	1985	The study also demonstrated that levels of interleukin 1 (IL-1) produced by lypopolysacharide-activated monocytes from cancer patients are significantly lower than they are in normal subjects.	lypopolysacharide	76-93	interleukin 1 alpha	Homo sapiens	43-62
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	130-134
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	130-134
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	130-134
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	130-134
2993420-6	1985	The enhanced binding and cytotoxicity of IL 1-treated target cells was only observed when the latter cells were preincubated with IL 1 at 37 degrees C, and was not evident at 4 degrees C. Furthermore, the IL 1-mediated effect could be abolished by treating the target cells with cycloheximide before the IL 1 pulse, or by adding rabbit anti-human IL 1 together with the IL 1.	Cycloheximide	279-292	interleukin 1 alpha	Homo sapiens	130-134
3928742-5	1985	The addition of highly purified IL 1 replenished both early and late T cell responses to SEPH-64.1 but not to SOL-64.1.	seph	89-93	interleukin 1 alpha	Homo sapiens	32-36
3876401-5	1985	IL-1 activity from lipopolysaccharide-treated endothelial cell supernatants could be absorbed by an antibody to IL-1 coupled to Sepharose.	Sepharose	128-137	interleukin 1 alpha	Homo sapiens	0-4
3876401-5	1985	IL-1 activity from lipopolysaccharide-treated endothelial cell supernatants could be absorbed by an antibody to IL-1 coupled to Sepharose.	Sepharose	128-137	interleukin 1 alpha	Homo sapiens	112-116
3876401-7	1985	Addition of cycloheximide blocked generation of IL-1 activity.	Cycloheximide	12-25	interleukin 1 alpha	Homo sapiens	48-52
3928742-6	1985	Although SOL-64.1 stimulation of purified T cells induced modulation of the CD3 complex, only SEPH-64.1 induced IL 1 responsiveness, and exogenous IL 1 was then able to support synthesis of RNA, secretion of IL 2, expression of IL 2R, and ultimately, DNA synthesis.	seph	94-98	interleukin 1 alpha	Homo sapiens	112-116
3876490-3	1985	The K-562 cell line was treated with the superinduction protocol involving phorbol myristate acetate (PMA) for production of human interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	75-100	interleukin 1 alpha	Homo sapiens	131-150
3879767-2	1985	Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.	Hydroxyl Radical	174-191	interleukin 1 alpha	Homo sapiens	101-114
3876490-3	1985	The K-562 cell line was treated with the superinduction protocol involving phorbol myristate acetate (PMA) for production of human interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	102-105	interleukin 1 alpha	Homo sapiens	131-150
3875561-3	1985	Non-cross-linked peptidoglycan polymers from penicillin-treated Streptococcus faecium were purified and shown to stimulate the production of interleukin 1 by human monocytes and of colony-stimulating factors by a murine macrophage cell line.	Penicillins	45-55	interleukin 1 alpha	Homo sapiens	141-154
2994686-2	1985	We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation.	Uric Acid	37-49	interleukin 1 alpha	Homo sapiens	147-166
2994686-2	1985	We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation.	Silicon Dioxide	54-69	interleukin 1 alpha	Homo sapiens	147-166
2994686-2	1985	We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation.	Silicon Dioxide	71-77	interleukin 1 alpha	Homo sapiens	147-166
3875561-5	1985	These in vitro results suggest that prolonged treatment with beta-lactam antibiotics, by causing the production of soluble peptidoglycan, may result in interleukin 1-mediated inflammatory reactions, excessive production of monocytes and granulocytes, and increased fibrin deposition.	beta-Lactams	61-72	interleukin 1 alpha	Homo sapiens	152-165
3875857-6	1985	IL-1, IL-2, and EGF also blocked suppression by SIRSox.	sirsox	48-54	interleukin 1 alpha	Homo sapiens	0-4
3902871-6	1985	IL-1 is highly inflammatory and increases the concentration of metabolites of arachidonic acid, most notably prostaglandin E2, in brain, muscle, chondrocytes, and synovial fibroblasts.	Arachidonic Acid	78-94	interleukin 1 alpha	Homo sapiens	0-4
3902871-6	1985	IL-1 is highly inflammatory and increases the concentration of metabolites of arachidonic acid, most notably prostaglandin E2, in brain, muscle, chondrocytes, and synovial fibroblasts.	Dinoprostone	109-125	interleukin 1 alpha	Homo sapiens	0-4
3875857-7	1985	However, EGF and IL-1 blocked suppression by SIRSox only when added 3-6 hr before addition of SIRSox, whereas IL-2 blocked suppression by SIRSox when added before or up to 3 hr after addition of SIRSox.	sirsox	45-51	interleukin 1 alpha	Homo sapiens	17-21
2993365-3	1985	The synovial cells produce collagenase and prostaglandin E2 (PGE2), the levels of which are increased when the cells are incubated with the monokine, mononuclear cell factor/interleukin 1.	Dinoprostone	43-59	interleukin 1 alpha	Homo sapiens	174-187
2994016-2	1985	By using this cDNA as a probe, human IL-1 cDNA was isolated from the cDNA library prepared using poly(A)+RNA from induced HL-60 cells, a human monocyte-like cell line.	Poly A	97-104	interleukin 1 alpha	Homo sapiens	37-41
2992505-1	1985	Human monocyte-derived Interleukin-1 (IL-1) stimulated a concentration-dependent extracellular release of azurophil (myeloperoxidase) and specific (vitamin B12-binding protein) granule constituents from cytochalasin B-treated human neutrophils.	azurophil	106-115	interleukin 1 alpha	Homo sapiens	23-36
2992505-1	1985	Human monocyte-derived Interleukin-1 (IL-1) stimulated a concentration-dependent extracellular release of azurophil (myeloperoxidase) and specific (vitamin B12-binding protein) granule constituents from cytochalasin B-treated human neutrophils.	azurophil	106-115	interleukin 1 alpha	Homo sapiens	38-42
2992505-1	1985	Human monocyte-derived Interleukin-1 (IL-1) stimulated a concentration-dependent extracellular release of azurophil (myeloperoxidase) and specific (vitamin B12-binding protein) granule constituents from cytochalasin B-treated human neutrophils.	Cytochalasin B	203-217	interleukin 1 alpha	Homo sapiens	23-36
2992505-1	1985	Human monocyte-derived Interleukin-1 (IL-1) stimulated a concentration-dependent extracellular release of azurophil (myeloperoxidase) and specific (vitamin B12-binding protein) granule constituents from cytochalasin B-treated human neutrophils.	Cytochalasin B	203-217	interleukin 1 alpha	Homo sapiens	38-42
3875350-4	1985	Finally, the isolated mitogen was shown to exhibit other properties of interleukin-1: stimulation of the secretion of interleukin-2, enhancement of the titer of acute-phase proteins in vivo, and stimulation of the release of prostaglandin E2 from human synoviocyte cultures.	Dinoprostone	225-241	interleukin 1 alpha	Homo sapiens	71-84
2993365-3	1985	The synovial cells produce collagenase and prostaglandin E2 (PGE2), the levels of which are increased when the cells are incubated with the monokine, mononuclear cell factor/interleukin 1.	Dinoprostone	61-65	interleukin 1 alpha	Homo sapiens	174-187
3924998-0	1985	The role of arachidonic acid metabolism in the activities of interleukin 1 and 2.	Arachidonic Acid	12-28	interleukin 1 alpha	Homo sapiens	61-80
3924998-2	1985	In this report we have studied the role of arachidonic acid metabolism in the specific effects of interleukin 1 (IL 1) induction of interleukin 2 (IL 2), and also IL 2 stimulation of proliferation and interferon-gamma (IFN-gamma) production.	Arachidonic Acid	43-59	interleukin 1 alpha	Homo sapiens	98-117
3924998-9	1985	The results suggest that both IL 1 and IL 2, and PMA, may share the lipoxygenase pathway of arachidonic acid metabolism which is a component of the intracellular signal transduction process that regulates secretory activity and/or cellular proliferation.	Arachidonic Acid	92-108	interleukin 1 alpha	Homo sapiens	30-34
3924998-3	1985	Utilizing cell lines that are specifically responsive to IL 1 or IL 2, it was found that both interleukins stimulate lipoxygenation of arachidonic acid in their respective target cell.	Arachidonic Acid	135-151	interleukin 1 alpha	Homo sapiens	57-61
3924998-5	1985	Utilizing selective and partially selective pharmacologic inhibitors of arachidonic acid metabolism, the data suggest that the participation of lipoxygenase activity is required for both IL 1 induction of IL 2 production and IL 2 regulation of proliferation and IFN-gamma secretion.	Arachidonic Acid	72-88	interleukin 1 alpha	Homo sapiens	187-191
2992486-6	1985	An oligonucleotide probe, complementary to the coding sequence of the Interleukin 1 cDNA isolated from human monocytes, hybridized specifically to this part of the gradient.	Oligonucleotides	3-18	interleukin 1 alpha	Homo sapiens	70-83
3895542-1	1985	To investigate the metabolic effects of interleukin-1 and its role as a mediator of host responses to trauma and sepsis, we injected seven healthy male subjects with etiocholanolone, an inflammatory agent that stimulates systemic responses thought to be mediated by interleukin-1.	Etiocholanolone	166-181	interleukin 1 alpha	Homo sapiens	40-53
3895542-1	1985	To investigate the metabolic effects of interleukin-1 and its role as a mediator of host responses to trauma and sepsis, we injected seven healthy male subjects with etiocholanolone, an inflammatory agent that stimulates systemic responses thought to be mediated by interleukin-1.	Etiocholanolone	166-181	interleukin 1 alpha	Homo sapiens	266-279
3998467-3	1985	Subsequent studies on SER showed that SER interfered with the production of interleukin 1 and 2 as well as interfering with their activities on target cells.	Serine	22-25	interleukin 1 alpha	Homo sapiens	76-95
3895542-3	1985	Etiocholanolone injection resulted in inflammation, fever, leukocytosis, increased serum C-reactive protein, hypoferremia, and increased plasma activity of interleukin-1/lymphocyte-activating factor.	Etiocholanolone	0-15	interleukin 1 alpha	Homo sapiens	156-169
2409598-0	1985	Prostacyclin synthesis induced in vascular cells by interleukin-1.	Epoprostenol	0-12	interleukin 1 alpha	Homo sapiens	52-65
2409598-3	1985	Interleukin-1-induced prostacyclin synthesis represents a new aspect of the interaction between the immune system (as well as other tissues) and the vessel wall and may serve as a basis for the development of new strategies in antithrombotic therapy.	Epoprostenol	22-34	interleukin 1 alpha	Homo sapiens	0-13
3873493-5	1985	The effect of IL 1 on monocyte-mediated cytotoxicity was partially inhibited by indomethacin, whereas pretreatment of monocytes with prostaglandin (PG) E1 or E2 rather than IL 1 also resulted in substantial monocyte cytotoxicity.	Indomethacin	80-92	interleukin 1 alpha	Homo sapiens	14-18
3873493-6	1985	Thus, the effect of IL 1 on monocyte-mediated cytotoxicity is presumably mediated by PGE.	Prostaglandins E	85-88	interleukin 1 alpha	Homo sapiens	20-24
3998467-3	1985	Subsequent studies on SER showed that SER interfered with the production of interleukin 1 and 2 as well as interfering with their activities on target cells.	Serine	38-41	interleukin 1 alpha	Homo sapiens	76-95
3875766-4	1985	Intracellular IL-1 had a mass of 30-40 kDa as determined by gel filtration using sephacryl-200 gel.	sephacryl-200	81-94	interleukin 1 alpha	Homo sapiens	14-18
3872905-3	1985	Two peaks of IL 1 inhibitory material were eluted from the polyacrylamide gels.	polyacrylamide	59-73	interleukin 1 alpha	Homo sapiens	13-17
3874022-4	1985	Five-fold dilution of supernatants from PBMC cultured at 10(6) cells/ml revealed more IL-1 activity than undiluted supernatant and addition of indomethacin increased IL-1 activity primarily of the undiluted supernatant.	Indomethacin	143-155	interleukin 1 alpha	Homo sapiens	166-170
2581705-1	1985	Human interleukin 1 (IL-1) in lipopolysaccharide and silica-stimulated human peripheral blood monocyte culture supernatants was purified to apparent homogeneity by sequential chromatography using DEAE-Sephacel, Sephacryl S-200, CM-high-performance liquid chromatography (HPLC), and hydroxyapatite-HPLC.	Silicon Dioxide	53-59	interleukin 1 alpha	Homo sapiens	6-25
2581705-1	1985	Human interleukin 1 (IL-1) in lipopolysaccharide and silica-stimulated human peripheral blood monocyte culture supernatants was purified to apparent homogeneity by sequential chromatography using DEAE-Sephacel, Sephacryl S-200, CM-high-performance liquid chromatography (HPLC), and hydroxyapatite-HPLC.	deae-sephacel	196-209	interleukin 1 alpha	Homo sapiens	6-25
2581705-1	1985	Human interleukin 1 (IL-1) in lipopolysaccharide and silica-stimulated human peripheral blood monocyte culture supernatants was purified to apparent homogeneity by sequential chromatography using DEAE-Sephacel, Sephacryl S-200, CM-high-performance liquid chromatography (HPLC), and hydroxyapatite-HPLC.	sephacryl S 200	211-226	interleukin 1 alpha	Homo sapiens	6-25
2581705-3	1985	IL-1 activity was eluted from a single site from PAGE performed in the absence of SDS.	Sodium Dodecyl Sulfate	82-85	interleukin 1 alpha	Homo sapiens	0-4
2581705-4	1985	About 4.4 micrograms of IL-1 was purified from 5.0 liters of culture supernatant of lipopolysaccharide- and silica-stimulated human peripheral blood monocytes, with 46.6% recovery of biological activity.	Silicon Dioxide	108-114	interleukin 1 alpha	Homo sapiens	24-28
3872340-1	1985	A protein with interleukin 1 (IL-1) activity was obtained from the human acute monocytic leukemia cell line (THP-1) and purified by ultrafiltration, Ultrogel AcA54 chromatography, isoelectric focusing, and discontinuous polyacrylamide gel electrophoresis.	polyacrylamide	220-234	interleukin 1 alpha	Homo sapiens	15-34
3158594-3	1985	IL-1 release was significantly augmented by the addition of indomethacin during stimulation.	Indomethacin	60-72	interleukin 1 alpha	Homo sapiens	0-4
2984302-8	1985	IL-1 was also released in higher amounts by IM than by RM in response to poly I:C.	Poly I-C	73-81	interleukin 1 alpha	Homo sapiens	0-4
3872340-2	1985	Like the pI 6.8 species of IL-1 from human peripheral blood monocytes (PBM), the cell line IL-1 has a molecular weight (MW) of 14,000, a pI of 6.8, is heat labile, and does not bind to concanavalin A-Sepharose.	Sepharose	200-209	interleukin 1 alpha	Homo sapiens	91-95
3872340-3	1985	Chemical modification of arginine residues by phenylglyoxal or sulfhydryl groups by N-ethyl maleimide and iodoacetamide completely destroys the activity of IL-1 from THP-1 cells as well as that of the pI 6.8 component from PBM.	Arginine	25-33	interleukin 1 alpha	Homo sapiens	156-160
3872340-3	1985	Chemical modification of arginine residues by phenylglyoxal or sulfhydryl groups by N-ethyl maleimide and iodoacetamide completely destroys the activity of IL-1 from THP-1 cells as well as that of the pI 6.8 component from PBM.	Ethylmaleimide	84-101	interleukin 1 alpha	Homo sapiens	156-160
3872340-3	1985	Chemical modification of arginine residues by phenylglyoxal or sulfhydryl groups by N-ethyl maleimide and iodoacetamide completely destroys the activity of IL-1 from THP-1 cells as well as that of the pI 6.8 component from PBM.	Iodoacetamide	106-119	interleukin 1 alpha	Homo sapiens	156-160
3872340-3	1985	Chemical modification of arginine residues by phenylglyoxal or sulfhydryl groups by N-ethyl maleimide and iodoacetamide completely destroys the activity of IL-1 from THP-1 cells as well as that of the pI 6.8 component from PBM.	pbm	223-226	interleukin 1 alpha	Homo sapiens	156-160
3872340-4	1985	In contrast, the pI 5.1 component of PBM IL-1 is resistant to heat denaturation and sulfhydryl reagents, although it is totally inactivated by phenylglyoxal.	Sulfhydryl Compounds	84-94	interleukin 1 alpha	Homo sapiens	41-45
3872340-4	1985	In contrast, the pI 5.1 component of PBM IL-1 is resistant to heat denaturation and sulfhydryl reagents, although it is totally inactivated by phenylglyoxal.	Phenylglyoxal	143-156	interleukin 1 alpha	Homo sapiens	41-45
3919095-3	1985	Human peripheral blood adherent leukocytes incubated with interferon (IFN) of three different species (alpha, beta, or gamma) show an enhanced potential of IL 1 synthesis and secretion that can be revealed by a second signal provided by endotoxins or Poly IC.	Poly I-C	251-258	interleukin 1 alpha	Homo sapiens	156-160
3873688-6	1985	Furthermore, addition of the prostaglandin synthesis inhibitor indomethacin gave rise to increased Il-1 production, HLA-class II expression, and a stronger antigen-specific T-cell response to PPD.	Prostaglandins	29-42	interleukin 1 alpha	Homo sapiens	99-103
3873688-6	1985	Furthermore, addition of the prostaglandin synthesis inhibitor indomethacin gave rise to increased Il-1 production, HLA-class II expression, and a stronger antigen-specific T-cell response to PPD.	Indomethacin	63-75	interleukin 1 alpha	Homo sapiens	99-103
3871221-2	1985	Human IL 1 was derived from the culture media of peripheral blood monocytes or placental cells that were stimulated with silica.	Silicon Dioxide	121-127	interleukin 1 alpha	Homo sapiens	6-10
2988854-2	1985	The levels of collagenase and PGE2 can be increased by a soluble factor present in mononuclear cell-conditioned medium, partially purified by gel-filtration, which has homologies with interleukin 1, and is produced by monocyte/macrophages.	Dinoprostone	30-34	interleukin 1 alpha	Homo sapiens	184-197
3871836-3	1985	IL-1, secreted by human peripheral blood macrophages that have been stimulated with Staphylococcus aureus, was purified by ion exchange chromatography and affinity chromatography on Procion Red agarose.	procion red agarose	182-201	interleukin 1 alpha	Homo sapiens	0-4
3872345-0	1985	Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis.	Prostaglandins	122-135	interleukin 1 alpha	Homo sapiens	39-52
3871791-3	1985	The low production of IL-1 in vitro correlated with patients" symptoms and therapy with 1-acetamide,2-pyrrolidone (1a,2p).	1-acetamide	88-99	interleukin 1 alpha	Homo sapiens	22-26
3155537-3	1985	Dex added at the beginning of the culture period inhibited, cell proliferation and IL 1/IL 2 synthesis, although not completely.	Dextromethorphan	0-3	interleukin 1 alpha	Homo sapiens	83-87
3871791-3	1985	The low production of IL-1 in vitro correlated with patients" symptoms and therapy with 1-acetamide,2-pyrrolidone (1a,2p).	2-pyrrolidone	100-113	interleukin 1 alpha	Homo sapiens	22-26
3917934-3	1985	15 kDa, which in addition to stimulating production of PGE2 and plasminogen activator by human articular chondrocytes, possessed interleukin 1 activity and induced cartilage degradation.	Dinoprostone	55-59	interleukin 1 alpha	Homo sapiens	129-142
3917862-0	1985	Calcium ionophore (A23187) increases interleukin 1 (IL-1) production by human peripheral blood monocytes and interacts synergistically with IL-1 to augment concanavalin A stimulated thymocyte proliferation.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	37-56
3917862-0	1985	Calcium ionophore (A23187) increases interleukin 1 (IL-1) production by human peripheral blood monocytes and interacts synergistically with IL-1 to augment concanavalin A stimulated thymocyte proliferation.	Calcium	0-7	interleukin 1 alpha	Homo sapiens	52-56
2419139-0	1986	Molecular requirement for interleukin 1 induction by lipopolysaccharide-stimulated human monocytes: involvement of the heptosyl-2-keto-3-deoxyoctulosonate region.	heptosyl-2-keto-3-deoxyoctonate	119-154	interleukin 1 alpha	Homo sapiens	26-39
3917862-0	1985	Calcium ionophore (A23187) increases interleukin 1 (IL-1) production by human peripheral blood monocytes and interacts synergistically with IL-1 to augment concanavalin A stimulated thymocyte proliferation.	Calcimycin	19-25	interleukin 1 alpha	Homo sapiens	37-56
3917862-0	1985	Calcium ionophore (A23187) increases interleukin 1 (IL-1) production by human peripheral blood monocytes and interacts synergistically with IL-1 to augment concanavalin A stimulated thymocyte proliferation.	Calcimycin	19-25	interleukin 1 alpha	Homo sapiens	52-56
2419139-4	1986	Similarly, the trisaccharide alpha-D-manno-heptopyranosyl-(1-3)-alpha-D-manno-heptopyranosyl -(1-5)-3 -deoxy-D-manno-octulosonic acid (hep-hep-KDO), representative for the inner-core region of a large number of enterobacterial LPS, was a very potent IL 1 inducer.	Trisaccharides	15-28	interleukin 1 alpha	Homo sapiens	250-254
3917862-1	1985	The effects of calcium ionophore, A23187, on production of interleukin 1 (IL-1) by human peripheral blood monocytes (PEMo) and on murine thymocyte proliferation were examined.	Calcium	15-22	interleukin 1 alpha	Homo sapiens	59-78
3917862-2	1985	A23187 induced IL-1 production by human PBMo.	Calcimycin	0-6	interleukin 1 alpha	Homo sapiens	15-19
2868825-8	1985	This suggests that one of the major mechanisms of action of adjuvant PG could be the stimulation of IL 1 synthesis.	pg	69-71	interleukin 1 alpha	Homo sapiens	100-104
2981169-3	1985	Addition of IL-1 resulted in partial restoration of the reaction of SLE PBMN to NaIO4, and a similar effect was demonstrated in the presence of phorbol myristate acetate (PMA).	metaperiodate	80-85	interleukin 1 alpha	Homo sapiens	12-16
2981169-6	1985	The results suggest that the defect in the response of SLE PBMN cells to NaIO4 is due to inadequate availability of IL-1 and IL-2.	metaperiodate	73-78	interleukin 1 alpha	Homo sapiens	116-120
2981690-3	1985	IL1 secretion appears to be PGE2 independent.	Dinoprostone	28-32	interleukin 1 alpha	Homo sapiens	0-3
2981690-5	1985	PGE2 (1.25 ng/ml) reduced the proliferative effect of IL 1 produced by 1.5 X 10(5) peritoneal M phi to 50%.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	54-58
2857137-5	1985	Opposing these effects of cyclic AMP are those of cyclic GMP and an expanding collection of compounds that increase its levels: acetylcholine (muscarinic), ascorbate, calcium ionophore, hydroperoxides of arachidonic acid, hypoxanthine derivatives, interleukin 1, serotonin, thymic hormones, and plant lectin mitogens.	Cyclic AMP	26-36	interleukin 1 alpha	Homo sapiens	248-261
2861158-0	1985	The role of serum in interleukin 1 production by human monocytes activated by endotoxins and their polysaccharide moieties.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	21-34
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	145-158
3917862-3	1985	The optimal dose was 10(-6) M. Although IL-1 production induced by A23187 was less than that by lipopolysaccharide (LPS) or silica, A23187 together with LPS had a synergistic effect on induction of IL-1.	Calcimycin	67-73	interleukin 1 alpha	Homo sapiens	40-44
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	22-24	interleukin 1 alpha	Homo sapiens	145-158
3917862-3	1985	The optimal dose was 10(-6) M. Although IL-1 production induced by A23187 was less than that by lipopolysaccharide (LPS) or silica, A23187 together with LPS had a synergistic effect on induction of IL-1.	Calcimycin	67-73	interleukin 1 alpha	Homo sapiens	198-202
3917862-3	1985	The optimal dose was 10(-6) M. Although IL-1 production induced by A23187 was less than that by lipopolysaccharide (LPS) or silica, A23187 together with LPS had a synergistic effect on induction of IL-1.	Calcimycin	132-138	interleukin 1 alpha	Homo sapiens	40-44
3917862-3	1985	The optimal dose was 10(-6) M. Although IL-1 production induced by A23187 was less than that by lipopolysaccharide (LPS) or silica, A23187 together with LPS had a synergistic effect on induction of IL-1.	Calcimycin	132-138	interleukin 1 alpha	Homo sapiens	198-202
3917862-5	1985	The optimal dose was also 10(-6) M. This represents the first report suggesting that monocytes or the monocyte product, IL-1, may contribute to the mitogenic effect of A23187 for thymocytes.	Calcimycin	168-174	interleukin 1 alpha	Homo sapiens	120-124
2861158-7	1985	The data presented suggest that the serum component(s) and the IL 1 inducers (LPS or PS) act in synergism by two different pathways since the two signals can be delivered sequentially.	Polysaccharides	79-81	interleukin 1 alpha	Homo sapiens	63-67
3881820-9	1985	IL-1 activity could not be measured directly in the supernatants owing to the synergistic effect of TPA in the assay system.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	0-4
3879241-3	1985	Furthermore, 1,25(OH)2D3 suppressed interleukin 1 (IL 1) production of monocytes (Mo), and the agent-treated Mo were unable to promote IL 2 production of non-adherent cells (NAC).	Calcitriol	13-24	interleukin 1 alpha	Homo sapiens	36-55
3879241-4	1985	Thus, the reduction of proliferative response of MNC to PHA by 1,25(OH)2D3 appeared to have resulted from the inhibitory effects of the agent on both IL 2 and IL 1 production.	25(oh)2d3	65-74	interleukin 1 alpha	Homo sapiens	159-163
3881820-10	1985	Unequivocal removal of the phorbol was not achieved, but the data indicated that the "real" levels of IL-1 in the TPA-induced cultures were not significantly higher than those from LPS-induced cultures.	Tetradecanoylphorbol Acetate	114-117	interleukin 1 alpha	Homo sapiens	102-106
6333848-7	1984	However, the biological activity of these two species of IL-1 was dissociated by treatment with N-ethylmaleimide (NEM), iodoacetamide (IAA), and heat.	Ethylmaleimide	96-112	interleukin 1 alpha	Homo sapiens	57-61
6335665-7	1984	Northern blot experiments with cloned TCGF DNA as a probe showed that TCGF mRNA was induced rapidly in cells treated with TPA and phytohemagglutinin, and this induction was augmented by interleukin 1.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 alpha	Homo sapiens	186-199
6333848-7	1984	However, the biological activity of these two species of IL-1 was dissociated by treatment with N-ethylmaleimide (NEM), iodoacetamide (IAA), and heat.	Ethylmaleimide	114-117	interleukin 1 alpha	Homo sapiens	57-61
6333848-7	1984	However, the biological activity of these two species of IL-1 was dissociated by treatment with N-ethylmaleimide (NEM), iodoacetamide (IAA), and heat.	Iodoacetamide	120-133	interleukin 1 alpha	Homo sapiens	57-61
6333848-7	1984	However, the biological activity of these two species of IL-1 was dissociated by treatment with N-ethylmaleimide (NEM), iodoacetamide (IAA), and heat.	Iodoacetamide	135-138	interleukin 1 alpha	Homo sapiens	57-61
6092094-0	1984	Induction of human interleukin 1 mRNA measured by collagenase- and prostaglandin E2-stimulating activity in rheumatoid synovial cells.	Dinoprostone	67-83	interleukin 1 alpha	Homo sapiens	19-32
6332318-0	1984	Interleukin 1 enhances synovial cell hyaluronate synthesis.	hyaluronate	37-48	interleukin 1 alpha	Homo sapiens	0-13
6332871-8	1984	Fresh monocytes secreted IL-1 readily in response to lipopolysaccaride and latex particles.	lipopolysaccaride	53-70	interleukin 1 alpha	Homo sapiens	25-29
6332871-8	1984	Fresh monocytes secreted IL-1 readily in response to lipopolysaccaride and latex particles.	Latex	75-80	interleukin 1 alpha	Homo sapiens	25-29
6332318-1	1984	Interleukin 1 enhances proliferation of murine thymocytes in the presence of lectins, and is also known to stimulate the release of prostaglandins and neutral proteases from a variety of cell types.	Prostaglandins	132-146	interleukin 1 alpha	Homo sapiens	0-13
6332318-3	1984	We report here that interleukin 1 from either source stimulates hyaluronate synthesis by synovial membrane cells.	hyaluronate	64-75	interleukin 1 alpha	Homo sapiens	20-33
6332318-4	1984	Upon gel filtration or isoelectric focusing of synovial cell supernatants, the hyaluronate-stimulatory activity co-fractionates with the interleukin 1 activity.	hyaluronate	79-90	interleukin 1 alpha	Homo sapiens	137-150
6332318-5	1984	Enhanced cell secretion of hyaluronate is a newly described metabolic effect of interleukin 1.	hyaluronate	27-38	interleukin 1 alpha	Homo sapiens	80-93
6331926-0	1984	Prostaglandin E2 depresses natural cytotoxicity by inhibiting interleukin-1 production by large granular lymphocytes.	Dinoprostone	0-16	interleukin 1 alpha	Homo sapiens	62-75
3874151-0	1985	Changes in the interleukin-1 and interleukin-2 generation in duodenal ulcer patients during cimetidine treatment.	Cimetidine	92-102	interleukin 1 alpha	Homo sapiens	15-28
6611596-6	1984	The structural and secretory (acute-phase reactants) in vitro protein synthesis in livers of normal rats injected intraperitoneally with IL-1 or PIF was significantly greater than that of normal rats or those injected with Ringer"s lactate (p less than 0.01).	Lactic Acid	232-239	interleukin 1 alpha	Homo sapiens	137-141
3874151-1	1985	The effect of cimetidine treatment on the generation of interleukin-1 (IL-1) and interleukin-2 (IL-2) was studied in 11 duodenal ulcer patients.	Cimetidine	14-24	interleukin 1 alpha	Homo sapiens	56-76
3874151-7	1985	In all ulcer patients IL-1 generation diminished during cimetidine treatment (P less than 0.005).	Cimetidine	56-66	interleukin 1 alpha	Homo sapiens	22-26
6611555-9	1984	IL-2 production by the patient"s phytohemagglutin-stimulated PBMC was severely deficient but was corrected by the addition of phorbol 12-myristate 13-acetate, suggesting a defective response to IL-1.	Tetradecanoylphorbol Acetate	126-157	interleukin 1 alpha	Homo sapiens	194-198
6379854-5	1984	Because the putative binding of IL-1 showed saturability, reversibility (with CyA as a probe), and tissue specificity consistent with a known target for the monokine, we propose that IL-1 interacts with a receptor-like structure on T cells.	Cyclosporine	78-81	interleukin 1 alpha	Homo sapiens	32-36
6332821-2	1984	Subsequently, the sample containing IL 1 activity was subjected to HPLC with a novel HPHT hydroxylapatite column.	hpht hydroxylapatite	85-105	interleukin 1 alpha	Homo sapiens	36-40
6332821-3	1984	Using a sodium phosphate gradient, IL 1 was eluted as a single peak of activity separated from the major protein contaminant, yielding 90% recovery and a specific activity of 6.3 X 10(4) U/mg.	sodium phosphate	8-24	interleukin 1 alpha	Homo sapiens	35-39
6332821-5	1984	From DEAE the IL 1 activity was eluted before a linear sodium chloride gradient was started, whereas the protein contaminant was eluted at 110 mM NaCl.	2-diethylaminoethanol	5-9	interleukin 1 alpha	Homo sapiens	14-18
6332821-5	1984	From DEAE the IL 1 activity was eluted before a linear sodium chloride gradient was started, whereas the protein contaminant was eluted at 110 mM NaCl.	Sodium Chloride	55-70	interleukin 1 alpha	Homo sapiens	14-18
6332821-7	1984	Fractions from the DEAE or TSK columns that were positive for IL 1 activity did not contain detectable protein, suggesting a good resolution.	2-diethylaminoethanol	19-23	interleukin 1 alpha	Homo sapiens	62-66
6379854-5	1984	Because the putative binding of IL-1 showed saturability, reversibility (with CyA as a probe), and tissue specificity consistent with a known target for the monokine, we propose that IL-1 interacts with a receptor-like structure on T cells.	Cyclosporine	78-81	interleukin 1 alpha	Homo sapiens	183-187
6610426-2	1984	Since one of the monocyte products, interleukin-1 (IL-1), has been shown to stimulate the release of collagenase and prostaglandin E from synoviocytes, we have investigated whether IL-1 is also responsible for chondrocyte activation.	Prostaglandins E	117-132	interleukin 1 alpha	Homo sapiens	36-55
6610426-2	1984	Since one of the monocyte products, interleukin-1 (IL-1), has been shown to stimulate the release of collagenase and prostaglandin E from synoviocytes, we have investigated whether IL-1 is also responsible for chondrocyte activation.	Prostaglandins E	117-132	interleukin 1 alpha	Homo sapiens	51-55
6610426-3	1984	Purified preparations of IL-1 derived from human blood monocytes stimulated the production of prostaglandin E and plasminogen activator by human articular chondrocytes.	Prostaglandins E	94-109	interleukin 1 alpha	Homo sapiens	25-29
6610426-4	1984	After Sephadex G-75 chromatography, the lymphocyte-activating and the chondrocyte-activating activities of IL-1 eluted together in the regions corresponding to the void volume and to Kav = 0.2-0.3 (Mr 30,000-45,000) and Kav = 0.5-0.65 (Mr 12,000-17,000).	sephadex	6-19	interleukin 1 alpha	Homo sapiens	107-111
6327874-5	1984	The ROHA -9-derived IL-1 activity eluted from Sephacryl S-200 in two peaks, at 15- 18K and 32- 35K mol wt, eluted from DEAE-Sephacel at 50-80 and 110-130 mM NaCl, and showed charge heterogeneity with peaks at pI 7.3, 6.1, and 4.1 on isoelectrofocusing (IEF).	sephacryl S 200	46-61	interleukin 1 alpha	Homo sapiens	20-24
6327874-5	1984	The ROHA -9-derived IL-1 activity eluted from Sephacryl S-200 in two peaks, at 15- 18K and 32- 35K mol wt, eluted from DEAE-Sephacel at 50-80 and 110-130 mM NaCl, and showed charge heterogeneity with peaks at pI 7.3, 6.1, and 4.1 on isoelectrofocusing (IEF).	deae-sephacel	119-132	interleukin 1 alpha	Homo sapiens	20-24
6327874-5	1984	The ROHA -9-derived IL-1 activity eluted from Sephacryl S-200 in two peaks, at 15- 18K and 32- 35K mol wt, eluted from DEAE-Sephacel at 50-80 and 110-130 mM NaCl, and showed charge heterogeneity with peaks at pI 7.3, 6.1, and 4.1 on isoelectrofocusing (IEF).	Sodium Chloride	157-161	interleukin 1 alpha	Homo sapiens	20-24
6320902-3	1984	The interleukin 1 and chondrocyte-stimulating activities are destroyed by pretreatment of the material with phenylglyoxal.	Phenylglyoxal	108-121	interleukin 1 alpha	Homo sapiens	4-17
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Silicon Dioxide	60-66	interleukin 1 alpha	Homo sapiens	204-208
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Zymosan	78-85	interleukin 1 alpha	Homo sapiens	204-208
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Tetradecanoylphorbol Acetate	90-115	interleukin 1 alpha	Homo sapiens	204-208
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 alpha	Homo sapiens	204-208
6325057-4	1984	During the same period of time, the addition of silica particles or PMA had clearly less effect while the addition of LPS or zymosan produced high levels of intracellular IL-1 but only a modest release of it.	Zymosan	125-132	interleukin 1 alpha	Homo sapiens	171-175
6610630-7	1984	However, concentrated CS from L428KS exhibited IL-1-activity also in this assay as did lipopolysaccharide (LPS) induced human IL-1.	Cesium	22-24	interleukin 1 alpha	Homo sapiens	47-51
6610630-11	1984	Addition of irradiated, autologous monocytes or of CS from the various Hodgkin cell lines quantitatively restored the ConA responsiveness and induced significant IL-2 production in the monocyte-depleted lymphocyte population, suggesting that Hodgkin lines constitutively secrete IL-1 or IL-1-like activity.	Cesium	51-53	interleukin 1 alpha	Homo sapiens	279-283
6610630-11	1984	Addition of irradiated, autologous monocytes or of CS from the various Hodgkin cell lines quantitatively restored the ConA responsiveness and induced significant IL-2 production in the monocyte-depleted lymphocyte population, suggesting that Hodgkin lines constitutively secrete IL-1 or IL-1-like activity.	Cesium	51-53	interleukin 1 alpha	Homo sapiens	287-291
6330537-0	1984	Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin.	Polysaccharides	70-84	interleukin 1 alpha	Homo sapiens	0-13
6330537-2	1984	This polysaccharide, previously found to be a very potent, macrophage-dependent, polyclonal B-cell activator and to mediate the specific binding of the endotoxin to macrophages, stimulated the interleukin 1 (IL 1) secretion by human monocytes; its potency was similar to that measured for the endotoxin.	Polysaccharides	5-19	interleukin 1 alpha	Homo sapiens	193-212
6330537-3	1984	It was concluded that endotoxin-induced IL 1 production may be initiated by the interaction of the polysaccharide chain of the B. pertussis endotoxin and a specific structure present on macrophages.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	40-44
6229371-2	1984	We have studied 16 untreated SLE patients to determine the production of IL-1 by their monocytes under the stimulus of E. Coli lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) and measured by the capacity of their supernatants to augment normal autologous mixed lymphocyte cultures (AMLR) or to replace accessory cells in Con A-induced proliferation of T lymphocytes.	Tetradecanoylphorbol Acetate	155-180	interleukin 1 alpha	Homo sapiens	73-77
6607791-4	1984	That this activity is Il-1 was shown by: (i) the time course of thymocyte stimulation; (ii) failure of PHA blast cells to absorb out the activity; (iii) molecular weight of 15,000-20,000 daltons, and (iv) ability to stimulate prostaglandin E2 production from synovial cells.	Dinoprostone	226-242	interleukin 1 alpha	Homo sapiens	22-26
6335406-0	1984	Effect of polyvinyl pyrrolidone derivative compound on production of interleukin-1 by monocytes.	Povidone	10-31	interleukin 1 alpha	Homo sapiens	69-82
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	1-acetamide	25-36	interleukin 1 alpha	Homo sapiens	93-106
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	1-acetamide	25-36	interleukin 1 alpha	Homo sapiens	108-112
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	2-pyrrolidone	38-51	interleukin 1 alpha	Homo sapiens	93-106
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	2-pyrrolidone	38-51	interleukin 1 alpha	Homo sapiens	108-112
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	pvp-a	53-58	interleukin 1 alpha	Homo sapiens	93-106
6335406-1	1984	We studied the effect of 1-acetamide, 2-pyrrolidone (PVP-A), a B-cell mitogen derivative, on interleukin-1 (IL-1) production by peripheral blood monocytes.	pvp-a	53-58	interleukin 1 alpha	Homo sapiens	108-112
6362935-4	1984	The addition to the culture of the adherent cell product interleukin 1 was effective in removing to a similar extent the steroid inhibitory effect on lymphocytes from normal and transplanted subjects.	Steroids	121-128	interleukin 1 alpha	Homo sapiens	57-70
6334041-3	1984	The steroid seemed to inhibit IL-2 production directly and not via reduced sensitivity to interleukin-1 by IL-2 producer T cells, or reduced IL-1 production by the antigen presenting monocytes.	Steroids	4-11	interleukin 1 alpha	Homo sapiens	141-145
6336003-4	1984	Both charged species of IL-1, pI 5.1 and 6.8 have a molecular weight of 14,500 as determined by SDS-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	96-99	interleukin 1 alpha	Homo sapiens	24-28
6207122-0	1984	Effect of isoprinosine on interleukin 1 and 2 production and on suppressor cell activity in pokeweed mitogen stimulated cultures of B and T cells.	Inosine Pranobex	10-22	interleukin 1 alpha	Homo sapiens	26-39
6207122-1	1984	Isoprinosine appeared to potentiate the production of interleukin 1 and interleukin 2 in cultures of lipopolysaccharide stimulated human monocytes and phytohemagglutinin stimulated cultures of blood mononuclear cells respectively at pharmacological drug levels.	Inosine Pranobex	0-12	interleukin 1 alpha	Homo sapiens	54-67
6336003-4	1984	Both charged species of IL-1, pI 5.1 and 6.8 have a molecular weight of 14,500 as determined by SDS-polyacrylamide gel electrophoresis.	polyacrylamide	100-114	interleukin 1 alpha	Homo sapiens	24-28
6321722-1	1983	Monocyte/macrophages release a factor, mononuclear cell factor (MCF), homologous with interleukin 1 (IL-1), which augments synthesis and release of collagenase and prostaglandins by connective tissue cells such as synovial cells and chondrocytes.	Prostaglandins	164-178	interleukin 1 alpha	Homo sapiens	86-105
6309415-1	1983	Human interleukin 1 (IL-1) was produced under serum-free conditions by stimulating a human monocytic leukemia cell line (THP-1) with silica or lipopolysaccharide (LPS).	Silicon Dioxide	133-139	interleukin 1 alpha	Homo sapiens	6-25
6606132-1	1983	Many activities are now ascribed to the monokine interleukin 1 including enhancement of immune responses, stimulation of thymocyte proliferation, activation of B cells, stimulation of proteinase and prostaglandin production by connective tissue cells, stimulation of the production of acute phase proteins, induction of fever and the induction of neutrophilia.	Prostaglandins	199-212	interleukin 1 alpha	Homo sapiens	49-62
6603165-3	1983	Results indicate that chloroquine inhibits tritiated thymidine in a dose-dependent way by interfering with the accessory function of monocytes, and that chloroquine inhibits the generation of immunoglobulin-secreting cells by selectively interfering with the secretion of Interleukin 1 by monocytes.	Chloroquine	22-33	interleukin 1 alpha	Homo sapiens	272-285
6331926-3	1984	It is concluded that the inhibition of natural killer (NK) cell activity produced by PGE2 is due to inhibition of IL-1 production by these cells.	Dinoprostone	85-89	interleukin 1 alpha	Homo sapiens	114-118
6604091-8	1983	We observed that only monocytes treated with paraformaldehyde after SLO or SpA pulsing stimulated a proliferative response by T lymphocytes, provided 50 U/ml of partially purified human IL 1 were added back to cultures.	paraform	45-61	interleukin 1 alpha	Homo sapiens	186-190
6603165-3	1983	Results indicate that chloroquine inhibits tritiated thymidine in a dose-dependent way by interfering with the accessory function of monocytes, and that chloroquine inhibits the generation of immunoglobulin-secreting cells by selectively interfering with the secretion of Interleukin 1 by monocytes.	Chloroquine	153-164	interleukin 1 alpha	Homo sapiens	272-285
6307572-5	1983	Leukocyte inhibiting factor (LIF) production by sodium periodate-activated mononuclear cells was also reduced after HC treatment, but could be corrected by adding IL-1-containing adherent cell supernatants to the cultures.	metaperiodate	48-64	interleukin 1 alpha	Homo sapiens	163-167
6602657-1	1983	The CM-S-produced IL-1 activity has been partially purified and shown to be similar to IL-1 produced by human and mouse peripheral blood macrophages.	Curium	4-8	interleukin 1 alpha	Homo sapiens	18-22
6602657-1	1983	The CM-S-produced IL-1 activity has been partially purified and shown to be similar to IL-1 produced by human and mouse peripheral blood macrophages.	Curium	4-8	interleukin 1 alpha	Homo sapiens	87-91
6603294-4	1983	In the presence of the macrophage product interleukin 1, the capacity of Dex to inhibit the mitogenesis of peripheral blood purified T cells (PBT) is inversely correlated with the PHA concentration used.	Dexamethasone	73-76	interleukin 1 alpha	Homo sapiens	42-55
6602068-1	1983	Human interleukin 1 (IL 1) has been purified to homogeneity by a procedure of molecular weight fractionation, isoelectric focusing, and preparative polyacrylamide gel electrophoresis.	polyacrylamide	148-162	interleukin 1 alpha	Homo sapiens	6-25
6602068-3	1983	The homogeneous IL 1 retains only a trace of its original biological activity because of the denturing effects of the sodium dodecyl sulfate used in the final step of purification.	Sodium Dodecyl Sulfate	118-140	interleukin 1 alpha	Homo sapiens	16-20
6602068-4	1983	Very highly purified IL 1, retaining strong biological activity, has been eluted from nondenaturing polyacrylamide gels.	polyacrylamide	100-114	interleukin 1 alpha	Homo sapiens	21-25
6407014-2	1983	That the action of A23187 is IL 1 independent was demonstrated by its ability to stimulate monocyte-depleted cells without the addition of exogenous IL 1.	Calcimycin	19-25	interleukin 1 alpha	Homo sapiens	29-33
6222114-8	1983	Whereas absorption of the anti-LP with PBM failed to remove the capacity to inhibit the generation of ISC, anti-LP-mediated inhibition of responsiveness could be reversed by the addition of crude M phi culture supernatants or a variety of highly purified interleukin 1 (IL 1) preparations, but not by T cell supernatants.	leucylproline	112-114	interleukin 1 alpha	Homo sapiens	255-268
6222114-8	1983	Whereas absorption of the anti-LP with PBM failed to remove the capacity to inhibit the generation of ISC, anti-LP-mediated inhibition of responsiveness could be reversed by the addition of crude M phi culture supernatants or a variety of highly purified interleukin 1 (IL 1) preparations, but not by T cell supernatants.	leucylproline	112-114	interleukin 1 alpha	Homo sapiens	270-274
6222114-9	1983	These results indicate anti-LP inhibits human B cell activation by removing the requisite M phi-derived factor IL 1 and also confirm that IL 1 plays an essential role in B cell proliferation and the generation of ISC in man.	leucylproline	28-30	interleukin 1 alpha	Homo sapiens	111-115
6222114-9	1983	These results indicate anti-LP inhibits human B cell activation by removing the requisite M phi-derived factor IL 1 and also confirm that IL 1 plays an essential role in B cell proliferation and the generation of ISC in man.	leucylproline	28-30	interleukin 1 alpha	Homo sapiens	138-142
6401308-0	1983	Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1.	Arachidonic Acid	8-20	interleukin 1 alpha	Homo sapiens	122-135
6402699-0	1983	Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1).	Dinoprostone	46-62	interleukin 1 alpha	Homo sapiens	94-107
6600979-5	1983	The addition of macrophages (M phi) or interleukin 1 (IL1) was effective in removing the Dex inhibitory effect on T cells purified from PBL, but not on thymocytes.	Dexamethasone	89-92	interleukin 1 alpha	Homo sapiens	39-52
6600979-5	1983	The addition of macrophages (M phi) or interleukin 1 (IL1) was effective in removing the Dex inhibitory effect on T cells purified from PBL, but not on thymocytes.	Dexamethasone	89-92	interleukin 1 alpha	Homo sapiens	54-57
6981846-4	1982	Stimulation of phagocytosis with latex beads increased the production and release of interleukin-1 from these placental cells, which may be a useful source of this protein.	Latex	33-38	interleukin 1 alpha	Homo sapiens	85-98
6801116-3	1982	We postulated that a cofactor, interleukin 1, present in the PU5-1.8 supernatants was responsible for protecting colony formation against steroid suppression.	Steroids	138-145	interleukin 1 alpha	Homo sapiens	31-44
6984130-2	1982	Its release is suggested to result from an altered synovial macrophage glutathione metabolism brought about by the action of interleukin 1 on host copper metabolism.	Glutathione	71-82	interleukin 1 alpha	Homo sapiens	125-138
6984130-2	1982	Its release is suggested to result from an altered synovial macrophage glutathione metabolism brought about by the action of interleukin 1 on host copper metabolism.	Copper	147-153	interleukin 1 alpha	Homo sapiens	125-138
6984130-4	1982	Alclofenac on interleukin 1, gold thiolates on copper-inhibited macrophage glutathione reductase, and D-penicillamine on IgC catabolism.	alclofenac	0-10	interleukin 1 alpha	Homo sapiens	14-27
6282982-5	1982	Monocyte-macrophages produce a stimulatory factor, which has homologies with interleukin 1, which not only increases collagenase synthesis but also PGE2 synthesis.	Dinoprostone	148-152	interleukin 1 alpha	Homo sapiens	77-90
6809339-0	1982	Modulation of interleukin 1 production by activated macrophages: in vitro action of hydrocortisone, colchicine, and cytochalasin B.	Hydrocortisone	84-98	interleukin 1 alpha	Homo sapiens	14-27
6809339-0	1982	Modulation of interleukin 1 production by activated macrophages: in vitro action of hydrocortisone, colchicine, and cytochalasin B.	Colchicine	100-110	interleukin 1 alpha	Homo sapiens	14-27
6809339-0	1982	Modulation of interleukin 1 production by activated macrophages: in vitro action of hydrocortisone, colchicine, and cytochalasin B.	Cytochalasin B	116-130	interleukin 1 alpha	Homo sapiens	14-27
6801122-5	1982	The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), has been shown to have IL 1-like effects in other species and is a polyclonal activator of human T and B lymphocytes.	Phorbol Esters	4-17	interleukin 1 alpha	Homo sapiens	87-91
6801122-5	1982	The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), has been shown to have IL 1-like effects in other species and is a polyclonal activator of human T and B lymphocytes.	Tetradecanoylphorbol Acetate	19-56	interleukin 1 alpha	Homo sapiens	87-91
6801122-5	1982	The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), has been shown to have IL 1-like effects in other species and is a polyclonal activator of human T and B lymphocytes.	Tetradecanoylphorbol Acetate	58-61	interleukin 1 alpha	Homo sapiens	87-91
6801122-8	1982	Thus, TPA appears to mimic the macrophage-replacing ability of soluble factors (IL 1, macrophage supernatants) in the triggering of human lymphocytes.	Tetradecanoylphorbol Acetate	6-9	interleukin 1 alpha	Homo sapiens	80-84
6801116-4	1982	Interleukin 1, isolated from culture supernatants of PU5-1.8 and from culture supernatants of human acute monocytic leukemia cells, blocked the inhabitory effects of dexamethasone on colony formation in response to L929 CSF.	Dexamethasone	166-179	interleukin 1 alpha	Homo sapiens	0-13
6801116-5	1982	Moreover, dexamethasone inhibited colony formation in response to PU5-1.8 culture supernatants when interleukin 1 was absent.	Dexamethasone	10-23	interleukin 1 alpha	Homo sapiens	100-113
6800841-4	1982	IL 1 can be depleted of lymphocyte-derived IL 2 by SP-Sephadex chromatography.	TFF2 protein, human	51-53	interleukin 1 alpha	Homo sapiens	0-4
6800841-4	1982	IL 1 can be depleted of lymphocyte-derived IL 2 by SP-Sephadex chromatography.	sephadex	54-62	interleukin 1 alpha	Homo sapiens	0-4
6800841-7	1982	Others have shown that IL 1 or closely related factors also stimulate hypothalamic cells to induce fever; induce in vitro fibroblast growth, prostaglandin, and collagenase production; and stimulate hepatocytes to produce acute phase proteins such as serum amyloid A. Murine epidermal cells also produce a 15,000-dalton factor that is mitogenic for thymocytes and may be similar to IL 1.	Prostaglandins	141-154	interleukin 1 alpha	Homo sapiens	23-27
6461917-5	1982	The addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A treated cultures significantly enhanced the synthesis of IL-2, Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR.	Hydrocortisone	274-288	interleukin 1 alpha	Homo sapiens	121-125
6461917-5	1982	The addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A treated cultures significantly enhanced the synthesis of IL-2, Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR.	Hydrocortisone	274-288	interleukin 1 alpha	Homo sapiens	121-125
6983710-6	1982	IL-1 produced in cultures by activated macrophages has been shown to stimulate T and B cell functions and to induce the production of collagenase and prostaglandins by cultured synovial cells.	Prostaglandins	150-164	interleukin 1 alpha	Homo sapiens	0-4
33683746-10	2021	Moreover, the analysis of palmitate-treated hiMGC secretome showed an upregulation of proangiogenic factors strongly related to DR, including ANG2, Endoglin, IL-1beta, CXCL8, MMP-9, PDGF-AA, and VEGF.	Palmitates	26-35	interleukin 1 alpha	Homo sapiens	158-166
6456149-0	1981	Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.	Cyclosporine	0-13	interleukin 1 alpha	Homo sapiens	107-120
6264478-0	1981	Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).	Prostaglandins	56-69	interleukin 1 alpha	Homo sapiens	133-146
6785531-7	1980	Isoelectric focusing (IEF) of the low MW IL-1 resulted in a very highly purified sample which was analyzed by polyacrylamide gel electrophoresis (PAGE).	polyacrylamide	110-124	interleukin 1 alpha	Homo sapiens	41-45
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	homoorientin	13-24	interleukin 1 alpha	Homo sapiens	175-183
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	orientin	16-24	interleukin 1 alpha	Homo sapiens	175-183
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	isovitexin	36-46	interleukin 1 alpha	Homo sapiens	175-183
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	vitexin	39-46	interleukin 1 alpha	Homo sapiens	175-183
34036391-6	2021	Then, the therapeutic effect of the selective P2X7R antagonist, A740003, on P3X7R, NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and IL-1beta alterations in HNECs was explored using enzyme-linked immunosorbent assay, WB and PCR.	(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)	64-71	interleukin 1 alpha	Homo sapiens	152-160
33934954-3	2021	The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021.	Curcumin	86-94	interleukin 1 alpha	Homo sapiens	107-111
33934954-8	2021	The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model.	Curcumin	43-51	interleukin 1 alpha	Homo sapiens	89-93
33934954-10	2021	Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-alpha, but not IL-6 and IL-8 levels.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	82-86
33887367-6	2021	The signature apparently relates to TNF- alpha, IL-1alpha, IL-1beta, IFN-alpha, IFN-beta, and IFN-gamma signaling, but not IL-6 signaling, suggesting that therapeutic effect of dexamethasone in COVID-19 does not involve IL-6 pathway.	Dexamethasone	177-190	interleukin 1 alpha	Homo sapiens	48-57
33887367-6	2021	The signature apparently relates to TNF- alpha, IL-1alpha, IL-1beta, IFN-alpha, IFN-beta, and IFN-gamma signaling, but not IL-6 signaling, suggesting that therapeutic effect of dexamethasone in COVID-19 does not involve IL-6 pathway.	Dexamethasone	177-190	interleukin 1 alpha	Homo sapiens	59-67
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	157-163	interleukin 1 alpha	Homo sapiens	87-95
33485222-1	2021	For the first time, we reported that CuONPs exposure induced interleukin (IL)-1beta-mediated inflammation via NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome in J774A.1 macrophage.	cuonps	37-43	interleukin 1 alpha	Homo sapiens	61-83
34000467-5	2021	Our results indicated that the activation of caspase-1 and the subsequent secretion of IL-1beta were significantly enhanced in infected macrophages under 1% oxygen, compared with those under a normal 20% oxygen concentration.	Oxygen	204-210	interleukin 1 alpha	Homo sapiens	87-95
34000467-10	2021	Our findings provide new insights into the intersection of low oxygen, H. pylori, and inflammation and disclosed how H. pylori under low oxygen tension can aggravate IL-1beta secretion.	Oxygen	63-69	interleukin 1 alpha	Homo sapiens	166-174
34000467-10	2021	Our findings provide new insights into the intersection of low oxygen, H. pylori, and inflammation and disclosed how H. pylori under low oxygen tension can aggravate IL-1beta secretion.	Oxygen	137-143	interleukin 1 alpha	Homo sapiens	166-174
33932778-6	2021	Synoviolin gene expression was ablated in adult hIL-1 cTg/Synoviolin cKO mice by injection of pIpC to activate Mx1 promoter-driven Cre recombinase.	Piperacillin	94-98	interleukin 1 alpha	Homo sapiens	48-53
32968210-9	2021	Cultured human and mouse podocytes were treated with high glucose (30 mM), which significantly increased the expression levels of caspase-11 or caspase-4 (the homolog of caspase-11 in human), GSDMD-N, NF-kappaB, IL-1beta, and IL-18, and decreased the expression of nephrin and podocin.	Glucose	58-65	interleukin 1 alpha	Homo sapiens	212-220
33899283-7	2021	Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines.	Bialaphos	31-34	interleukin 1 alpha	Homo sapiens	219-227
33899283-7	2021	Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines.	Bialaphos	105-108	interleukin 1 alpha	Homo sapiens	219-227
33894403-7	2021	Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX.	np-rlx	13-19	interleukin 1 alpha	Homo sapiens	88-96
33894403-7	2021	Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX.	np-rlx	13-19	interleukin 1 alpha	Homo sapiens	172-180
33894403-7	2021	Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX.	Relaxin	16-19	interleukin 1 alpha	Homo sapiens	88-96
33894403-7	2021	Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX.	Relaxin	16-19	interleukin 1 alpha	Homo sapiens	172-180
32712770-4	2021	In contrast, ziram at 10 mumol.L-1 completely inhibited this phagocytic process, the oxidative burst triggered by zymosan and the production of TNF-alpha, IL-1beta, IL-6, and CCL2 triggered by LPS.	Ziram	13-18	interleukin 1 alpha	Homo sapiens	155-163
33388995-8	2021	IL-1beta and TNFalpha significantly correlated among them before and after platinum-based chemotherapy.	Platinum	75-83	interleukin 1 alpha	Homo sapiens	0-8
33169272-3	2021	This study focused on the effects of the induced inflammation by IL-1ss in compressed human periodontal ligament fibroblasts (HPdLF) exposed to the nitrogen-containing BP zoledronate in vitro.	Nitrogen	148-156	interleukin 1 alpha	Homo sapiens	65-69
33945870-3	2021	As CAPS was genetically confirmed, the inhibition of interleukin-1 (IL-1) with anakinra led to a swift resolution of the CAPS symptoms and also, in combination with teriflunomide, to a clinical and imaging improvement of MS.	teriflunomide	165-178	interleukin 1 alpha	Homo sapiens	53-72
33169272-3	2021	This study focused on the effects of the induced inflammation by IL-1ss in compressed human periodontal ligament fibroblasts (HPdLF) exposed to the nitrogen-containing BP zoledronate in vitro.	bp zoledronate	168-182	interleukin 1 alpha	Homo sapiens	65-69
33979025-6	2021	Accordingly, IL-1beta stimulation also increased oxygen consumption rate, but without a concomitant rise in fatty acid oxidation.	Oxygen	49-55	interleukin 1 alpha	Homo sapiens	13-21
33677134-10	2021	Compared to the UVA-irradiated skin, 30 % TiO2/SBA-15 showed a 2.5- and 3.1-fold decline in IL-1beta and IL-6 levels, respectively.	titanium dioxide	42-46	interleukin 1 alpha	Homo sapiens	92-100
33677134-10	2021	Compared to the UVA-irradiated skin, 30 % TiO2/SBA-15 showed a 2.5- and 3.1-fold decline in IL-1beta and IL-6 levels, respectively.	sba	47-50	interleukin 1 alpha	Homo sapiens	92-100
33979025-7	2021	Together, this suggests that the IL-1beta-stimulated energy shift is driven by shunting of glucose-derived pyruvate into mitochondria to maintain elevated oxygen consumption in HUVECs.	Glucose	91-98	interleukin 1 alpha	Homo sapiens	33-41
33979025-7	2021	Together, this suggests that the IL-1beta-stimulated energy shift is driven by shunting of glucose-derived pyruvate into mitochondria to maintain elevated oxygen consumption in HUVECs.	Pyruvic Acid	107-115	interleukin 1 alpha	Homo sapiens	33-41
33979025-7	2021	Together, this suggests that the IL-1beta-stimulated energy shift is driven by shunting of glucose-derived pyruvate into mitochondria to maintain elevated oxygen consumption in HUVECs.	Oxygen	155-161	interleukin 1 alpha	Homo sapiens	33-41
33676147-0	2021	L-Threoascorbic acid treatment promotes S. aureus-infected primary human endothelial cells survival and function, as well as intracellular bacterial killing, and immunomodulates the release of IL-1beta and soluble ICAM-1.	Ascorbic Acid	0-20	interleukin 1 alpha	Homo sapiens	193-201
33813846-11	2021	Inhibition of NETs formation with Cl-amidine decreased mRNA expression of proinflammatory cytokines (intercellular adhesion molecule 1 (ICAM-1), interleukin 1 beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha)) in cerebral arteries.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	34-44	interleukin 1 alpha	Homo sapiens	165-173
33684877-13	2021	MiR-515-5p restoration alleviated IL-1beta-induced chondrocyte apoptosis, inflammatory responses and ECM degradation, While SOCS1 overexpression partly abolished these effects.	mir-515-5p	0-10	interleukin 1 alpha	Homo sapiens	34-42
33676147-12	2021	Finally, AscH2 treatment has a slight effect on the production of interleukin 6 (IL-6), but induced a marked downregulation of that of IL-1beta in S. aureus-infected HUVECs (respectively, p > 0.05, and p < 0.05).	asch2	9-14	interleukin 1 alpha	Homo sapiens	135-143
33735716-0	2021	Corrigendum to "Baicalin suppresses IL-1beta-induced expression of inflammatory cytokines via blocking NF-kappaB in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models" [Int.	baicalin	16-24	interleukin 1 alpha	Homo sapiens	36-44
33333123-5	2021	Furthermore, we provide evidence for excessive full-length IL-1alpha signaling in the microenvironment of IMQ-treated Ovol1-deficient skin that functionally contributes to immune cell infiltration and epidermal hyperplasia.	Imiquimod	106-109	interleukin 1 alpha	Homo sapiens	59-68
33053260-7	2021	RESULTS: We found that 0.3% SLS treatment and 1% Triton X-100 in 3D skin models resulted in a tissue activity of less than 20% and increased IL-1alpha release.	Octoxynol	49-61	interleukin 1 alpha	Homo sapiens	141-150
33164235-0	2021	Hydrogen sulfide protects against IL-1beta-induced inflammation and mitochondrial dysfunction-related apoptosis in chondrocytes and ameliorates osteoarthritis.	Hydrogen Sulfide	0-16	interleukin 1 alpha	Homo sapiens	34-42
33164235-4	2021	In the current study, the role of endogenous H2 S in the pathogenesis of OA and its protective effects on interleukin (IL)-1beta-induced chondrocytes were identified.	Deuterium	45-49	interleukin 1 alpha	Homo sapiens	106-128
33164235-5	2021	Our data revealed decreased H2 S expression in both human degenerative OA cartilage tissue and IL-1beta-induced chondrocytes.	Deuterium	28-32	interleukin 1 alpha	Homo sapiens	95-103
33164235-6	2021	Pretreatment with the H2 S donor sodium hydrosulfide (NaHS) dramatically attenuated IL-1beta-induced overproduction of inflammatory cytokines and improved the balance between anabolic and catabolic chondrocyte capacities, and these effects were dependent on PI3K/AKT pathway-mediated inhibition of nuclear factor kappa B (NF-kappaB).	Deuterium	22-26	interleukin 1 alpha	Homo sapiens	84-92
33164235-6	2021	Pretreatment with the H2 S donor sodium hydrosulfide (NaHS) dramatically attenuated IL-1beta-induced overproduction of inflammatory cytokines and improved the balance between anabolic and catabolic chondrocyte capacities, and these effects were dependent on PI3K/AKT pathway-mediated inhibition of nuclear factor kappa B (NF-kappaB).	sodium bisulfide	33-52	interleukin 1 alpha	Homo sapiens	84-92
32676889-9	2021	Moreover, NaHS administration reduced the expression of microglial M1 phenotype markers (IL-1beta, TNF-alpha and nitrite) and concomitantly increased the expression of M2 phenotype markers (IL-4 and TGF-beta) in the brain regions of LPS treated animals.	sodium bisulfide	10-14	interleukin 1 alpha	Homo sapiens	89-97
33164235-6	2021	Pretreatment with the H2 S donor sodium hydrosulfide (NaHS) dramatically attenuated IL-1beta-induced overproduction of inflammatory cytokines and improved the balance between anabolic and catabolic chondrocyte capacities, and these effects were dependent on PI3K/AKT pathway-mediated inhibition of nuclear factor kappa B (NF-kappaB).	sodium bisulfide	54-58	interleukin 1 alpha	Homo sapiens	84-92
33164235-7	2021	Moreover, mitochondrial dysfunction-related apoptosis was significantly reversed by NaHS in IL-1beta-stimulated chondrocytes.	sodium bisulfide	84-88	interleukin 1 alpha	Homo sapiens	92-100
33164235-8	2021	Mechanistically, NaHS partially suppressed IL-1beta-induced phosphorylation of the mitogen-activated protein kinase (MAPK) cascades.	sodium bisulfide	17-21	interleukin 1 alpha	Homo sapiens	43-51
33846813-0	2021	Celastrol attenuates the inflammatory response by inhibiting IL-1beta expression in triple-negative breast cancer cells.	celastrol	0-9	interleukin 1 alpha	Homo sapiens	61-69
33405196-6	2021	The rate-limiting enzymes of cholesterol metabolism (CYP46A1) in SH-SY5Y cells and synthesis (HMGCR) in U251 cells were altered by inflammation stimulators, including LPS, IL-1beta, and TNF-alpha, through the TLR4/MyD88/NF-kappaB signaling pathway.	Cholesterol	29-40	interleukin 1 alpha	Homo sapiens	172-180
33417168-13	2021	By constructing a DRG supernatant-M1 macrophage adoptive culture model, we found that the supernatant of DRG after PBM intervention could reduce the expression level of iNOS and the secretion of TNF-alpha and IL-1beta in M1 macrophages; at the same time, it could also up-regulate the expression of Arg-1, one of the markers of M2 macrophages.	pbm	115-118	interleukin 1 alpha	Homo sapiens	209-217
33580871-3	2021	Our previous work identified that chronic escalating heroin administration and withdrawal can produce enhanced fear learning, an animal model of hyperarousal, and is associated with an increase in dorsal hippocampal (DH) interleukin-1beta (IL-1beta).	Heroin	53-59	interleukin 1 alpha	Homo sapiens	240-248
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	3-methyladenine	9-13	interleukin 1 alpha	Homo sapiens	160-168
33857603-4	2021	PGE2 strongly increased DUSP-1 and suppressed IL-1beta-induced MAPKs phosphorylation.	Dinoprostone	0-4	interleukin 1 alpha	Homo sapiens	46-54
34056995-7	2021	Therefore, this work demonstrates for the first time that L-carnosine may be used as adjuvant therapy for the preservation of visual integrity in patients with DED.HighlightsIL-1alpha induced dry eye disease through its oxidative stress, proinflammatory, apoptotic and profibrotic effects on the lacrimal glands of rabbit.L-carnosine has antioxidant, anti-inflammatory, antiapoptotic and antifibrotic effects.L-carnosine mitigated IL-1alpha induced dry eye disease via elevating the levels of FasL, IFN-gamma, TNF-alpha, TGFbeta1 and MDA as well as reducing the levels of antioxidants (GPx, SOD, and catalase) and ROS in the lacrimal glands of rabbit.L-carnosine could be used as a novel adjuvant therapy for the treatment of dry eye disease.	ros	614-617	interleukin 1 alpha	Homo sapiens	174-183
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	interleukin 1 alpha	Homo sapiens	160-168
34051020-9	2021	Azilsartan reduced AGEs-induced production of proinflammatory cytokines, such as IL-1alpha, TNF-beta, and IL-6.	azilsartan	0-10	interleukin 1 alpha	Homo sapiens	81-90
34059097-1	2021	BACKGROUND: Cryopyrin-associated periodic syndrome (CAPS) is a life-long, autoinflammatory disease associated with a gain-of-function mutation in the nucleotide-binding domain, leucine-rich repeat family, pyrin domain containing 3 (NLRP3) gene, which result in uncontrolled production of IL-1beta and chronic inflammation.	Leucine	177-184	interleukin 1 alpha	Homo sapiens	288-296
34058186-3	2021	Fatty acid oxidation (FAO) was previously demonstrated to interact with the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) pathway which is required for mature IL-1beta secretion.	Fatty Acids	0-10	interleukin 1 alpha	Homo sapiens	170-178
34050880-8	2021	In addition, following 15-min tCCAo, pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta)] immunoreactivity was significantly higher than that seen following 5-min tCCAo, whereas immunoreactivity of anti-inflammatory cytokines (IL-4 and IL-13) was lower in 15-min than 5-min tCCAo.	tccao	30-35	interleukin 1 alpha	Homo sapiens	129-137
34046979-4	2021	Importantly, IL-1alpha regulates fibroblast Cox-2 expression and prostaglandin E2 (PGE2 ) secretion, thereby linking keratinocyte integrin function to a paracrine signal that suppresses the myofibroblast phenotype.	Dinoprostone	65-81	interleukin 1 alpha	Homo sapiens	13-22
33955754-0	2021	Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1beta Axis.	Cannabidiol	0-11	interleukin 1 alpha	Homo sapiens	126-134
33955754-5	2021	CBD treatment down-regulated the mRNA expression levels of CASP1 and IL1B (by 32.9 and 51.0%, respectively) and reduced IL-1beta level (by 16.2%) in H2O2-stimulated HaCaT cells.	Cannabidiol	0-3	interleukin 1 alpha	Homo sapiens	120-128
33955754-5	2021	CBD treatment down-regulated the mRNA expression levels of CASP1 and IL1B (by 32.9 and 51.0%, respectively) and reduced IL-1beta level (by 16.2%) in H2O2-stimulated HaCaT cells.	Hydrogen Peroxide	149-153	interleukin 1 alpha	Homo sapiens	120-128
33955754-8	2021	The findings from the current study suggest that CBD exerts protective effects in human keratinocytes via the modulation of the caspase-1-IL-1beta axis, supporting its potential skin health applications.	Cannabidiol	49-52	interleukin 1 alpha	Homo sapiens	138-146
34046979-4	2021	Importantly, IL-1alpha regulates fibroblast Cox-2 expression and prostaglandin E2 (PGE2 ) secretion, thereby linking keratinocyte integrin function to a paracrine signal that suppresses the myofibroblast phenotype.	Dinoprostone	83-87	interleukin 1 alpha	Homo sapiens	13-22
34021857-7	2021	RESULTS: Enzyme-linked immunosorbent assay (ELISA) demonstrated that IL-1beta, IL-6, and TNF-alpha upregulated by lipopolysaccharide (LPS) was decreased by treatment with GB.	glabridin	171-173	interleukin 1 alpha	Homo sapiens	69-77
34038062-10	2021	Over-expression of miR-874-3p attenuated LPS-induced increase of TNF-alpha and IL-1beta and reversed LPS-induced decrease of cell viability and increase of cell apoptosis in HPAEpiC.	mir-874-3p	19-29	interleukin 1 alpha	Homo sapiens	79-87
34045139-9	2021	The expressions of FOXC1, TNF-alpha, IL-6, PGE2, MMP-1, MMP-13 and COX-2 were up-regulated in IL-1beta-treated SFs.	Dinoprostone	43-47	interleukin 1 alpha	Homo sapiens	94-102
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Thyrotropin	168-171	interleukin 1 alpha	Homo sapiens	68-77
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Triiodothyronine	192-208	interleukin 1 alpha	Homo sapiens	68-77
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Triiodothyronine	210-212	interleukin 1 alpha	Homo sapiens	68-77
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Thyroxine	218-236	interleukin 1 alpha	Homo sapiens	68-77
34052311-0	2021	Synergistic effects of electronegative-LDL- and palmitic-acid-triggered IL-1beta production in macrophages via LOX-1- and voltage-gated-potassium-channel-dependent pathways.	Palmitic Acid	48-61	interleukin 1 alpha	Homo sapiens	72-80
34052311-7	2021	In potassium-free buffer, LDL(-)-induced IL-1beta reached a level similar to that induced by cotreatment with LDL(-) and PA-BSA.	Potassium	3-12	interleukin 1 alpha	Homo sapiens	41-49
34052623-5	2021	In this study, we found that PRV infection caused significant secretion of several pro-inflammatory cytokines in macrophages and promoted IL-1beta secretion in an ATP-dependent manner.	Adenosine Triphosphate	163-166	interleukin 1 alpha	Homo sapiens	138-146
34052623-6	2021	Furthermore, the expression of IL-1beta can be induced by only PRV infection and depended on NF-kappaB pathway activation, while the subsequent secretion of IL-1beta was mediated by ATP-induced P2 x 7R activation, loss of intracellular K+, and the subsequent NLRP3 inflammasome activation.	Adenosine Triphosphate	182-185	interleukin 1 alpha	Homo sapiens	157-165
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	-stimulating hormone	146-166	interleukin 1 alpha	Homo sapiens	68-77
34033934-17	2021	Both biomarkers failed to maintain the reduction in both groups and significantly increased levels for IL-1beta was noted at 6 months follow up Conclusion: Multiple application of indocyanine-green mediated photodynamic therapy resulted in improved clinical and microbial parameters among type 2 DM subjects in the treatment of peri-implantitis.	Indocyanine Green	180-197	interleukin 1 alpha	Homo sapiens	103-111
34023356-4	2021	Within IL-1beta-stimulated NP cells, we observed degenerative and inflammatory changes, including inhibited cell viability, promoted cell apoptosis and ROS accumulation, reduced collagen II and aggrecan proteins, elevated MMP-3/13 and ADAMTS-4/5 proteins, and upregulated IL-6 and TNF-alpha mRNA levels.	Reactive Oxygen Species	152-155	interleukin 1 alpha	Homo sapiens	7-15
34024891-7	2021	Cardamonin reversed the effect of IL-1beta on cell viability, cell apoptosis, pro-inflammatory cytokines, MMPs, Collage II, NLRP3 inflammasome levels.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	34-42
34019587-9	2021	Moreover, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126, p38 inhibitor SB205380, JNK inhibitor SP600125 and Akt inhibitor GSK 690693 decreased IL-1beta-induced MMP-3 mRNA and protein expression.	U 0126	84-89	interleukin 1 alpha	Homo sapiens	177-185
34019587-9	2021	Moreover, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126, p38 inhibitor SB205380, JNK inhibitor SP600125 and Akt inhibitor GSK 690693 decreased IL-1beta-induced MMP-3 mRNA and protein expression.	sb205380	105-113	interleukin 1 alpha	Homo sapiens	177-185
34019587-9	2021	Moreover, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126, p38 inhibitor SB205380, JNK inhibitor SP600125 and Akt inhibitor GSK 690693 decreased IL-1beta-induced MMP-3 mRNA and protein expression.	pyrazolanthrone	129-137	interleukin 1 alpha	Homo sapiens	177-185
34019587-9	2021	Moreover, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126, p38 inhibitor SB205380, JNK inhibitor SP600125 and Akt inhibitor GSK 690693 decreased IL-1beta-induced MMP-3 mRNA and protein expression.	GSK690693	156-166	interleukin 1 alpha	Homo sapiens	177-185
34024891-0	2021	Cardamonin Inhibited IL-1beta-induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO1 Signaling Pathway in Chondrocyte.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	21-29
34024891-10	2021	Cardamonin inhibited IL-1beta-induced injury by inhibition of NLRP3 inflammasome via activating Nrf2/NQO1 signaling pathway in chondrocyte.	cardamonin	0-10	interleukin 1 alpha	Homo sapiens	21-29
34002852-9	2021	In conclusion, our results reveal an important role of CD300a in the control of leukocyte infiltration, IL-1beta production and caspase-8 cleavage in neutrophils, contributing to the resolution of inflammation triggered by MSU injection.	Uric Acid	223-226	interleukin 1 alpha	Homo sapiens	104-112
34006824-3	2021	Here, we show that the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1beta secretion and pyroptosis.	perfluorooctane sulfonic acid	78-103	interleukin 1 alpha	Homo sapiens	146-154
34006824-3	2021	Here, we show that the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1beta secretion and pyroptosis.	perfluorooctane sulfonic acid	105-109	interleukin 1 alpha	Homo sapiens	146-154
34006824-3	2021	Here, we show that the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1beta secretion and pyroptosis.	pfas	129-133	interleukin 1 alpha	Homo sapiens	146-154
33998910-5	2021	There is accumulating evidence that dietary polyphenols may show therapeutic efficacy in RA through their antioxidant, anti-inflammatory, apoptotic, and immunosuppressant activities and modulation of the tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, mitogen-activated protein kinase (MAPK), IL-1beta, c-Jun N-terminal kinase (JNK), and nuclear factor kappa light-chain-enhancer of activated B cell (NF-kappaB) pathways.	Polyphenols	44-55	interleukin 1 alpha	Homo sapiens	306-314
34006936-7	2021	Addition of ATP to cells following ceramic treatment significantly increased IL-1beta secretion.	Adenosine Triphosphate	12-15	interleukin 1 alpha	Homo sapiens	77-85
33713693-10	2021	Ethanol exposure decreased cell viability and the expression of BDNF and increased the cell apoptosis rate and the expression of BAX, cleaved caspase-3, IL-1beta and IL-6.	Ethanol	0-7	interleukin 1 alpha	Homo sapiens	153-161
33989405-7	2021	TNFalpha measurably increased secretion of IL-8 and IL-1beta, which was enhanced at 60 mM glucose.	Glucose	90-97	interleukin 1 alpha	Homo sapiens	52-60
34055794-9	2021	In contrast, the ACh-alpha7nAChR axis in ILC2 diminishes the synthesis of TNF-alpha, IL-1, and IL-6, attenuating lung inflammation whereas, VIP-VPAC1, N/OFQ-NOP axes cause bronchodilation and anti-inflammatory effects.	Acetylcholine	17-20	interleukin 1 alpha	Homo sapiens	85-89
34054818-9	2021	dmLT, ETVAX WCC and LPS induced dose-dependent IL-1beta responses of comparable magnitudes in infant and adult cells.	dmlt	0-4	interleukin 1 alpha	Homo sapiens	47-55
34054818-9	2021	dmLT, ETVAX WCC and LPS induced dose-dependent IL-1beta responses of comparable magnitudes in infant and adult cells.	etvax wcc	6-15	interleukin 1 alpha	Homo sapiens	47-55
34054818-11	2021	dmLT enhanced IL-1beta responses to low doses of WCC and LPS, and the adjuvant effect appeared over a wider dose-range of WCC in infants.	dmlt	0-4	interleukin 1 alpha	Homo sapiens	14-22
33295622-16	2021	CONCLUSION: In patients who were refractory to colchicine, anti-IL-1 agent anakinra was shown to be effective and safe.	Colchicine	47-57	interleukin 1 alpha	Homo sapiens	64-68
34025070-14	2021	In vivo, SB2035080 attenuated lung histopathological injury, decreased inflammatory activity (TNF-alpha, IL-1beta, IL-6 and myeloperoxidase) and preserved pulmonary function.	sb2035080	9-18	interleukin 1 alpha	Homo sapiens	105-113
33970450-7	2021	RESULTS: Based on the findings, Rifampicin and Letermovir appeared as the most promising drug showing a very good binding affinity with the main protease of SARS-CoV-2 and TNF-alpha, IL-6, and IL-1beta.	Rifampin	32-42	interleukin 1 alpha	Homo sapiens	193-201
33982180-6	2021	Inhibition of caspase-1 by Belnacasan (VX-765) suppressed the transcription of IL-1beta, reduced cell lysis, and significantly promoted IBDV replication in DF-1 cells.	belnacasan	27-37	interleukin 1 alpha	Homo sapiens	79-87
33982180-6	2021	Inhibition of caspase-1 by Belnacasan (VX-765) suppressed the transcription of IL-1beta, reduced cell lysis, and significantly promoted IBDV replication in DF-1 cells.	belnacasan	39-45	interleukin 1 alpha	Homo sapiens	79-87
34007158-9	2021	FTY720 reduced the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Fingolimod Hydrochloride	0-6	interleukin 1 alpha	Homo sapiens	32-40
34055197-11	2021	Results demonstrated that the IL-1beta/NF-kappaB signaling pathway was one of the critical signaling pathways of FZQX prescription regulating MDSCs to prevent the recurrence and metastasis of lung adenocarcinoma.	fzqx	113-117	interleukin 1 alpha	Homo sapiens	30-38
33970450-7	2021	RESULTS: Based on the findings, Rifampicin and Letermovir appeared as the most promising drug showing a very good binding affinity with the main protease of SARS-CoV-2 and TNF-alpha, IL-6, and IL-1beta.	letermovir	47-57	interleukin 1 alpha	Homo sapiens	193-201
33986196-3	2021	We found that beta-glucan-trained miR-9-5p-/- monocytes showed decreased IL-1beta, IL-6, and TNF-alpha production after LPS stimulation.	beta-Glucans	14-25	interleukin 1 alpha	Homo sapiens	73-81
33961144-7	2021	Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6.	Flavonoids	0-10	interleukin 1 alpha	Homo sapiens	189-197
33957967-11	2021	The autophagy promoter (3-MA) and inhibitor (rapamycin) significantly decreased or increased the expression of TNF-alpha, IL-6, and IL-1beta by DCs.	Sirolimus	45-54	interleukin 1 alpha	Homo sapiens	132-140
34025440-4	2021	Furthermore, in RPE cells exposed to HG we observed a significant increase of iNOS, COX-2, and IL-1beta expression, that was reverted by DMF treatment.	Dimethyl Fumarate	137-140	interleukin 1 alpha	Homo sapiens	95-103
33958662-2	2021	Palmitic acid (PA) is elevated in the sera of diabetics and stimulates the production of the DR-relevant cytokines by MC, including IL-1beta, which induces the production of itself and other inflammatory cytokines in the retina as well.	Palmitic Acid	0-13	interleukin 1 alpha	Homo sapiens	132-140
34025636-6	2021	Functional clustering of the differentially regulated genes in SZ95 sebocytes treated with EGF, PA or co-treated with EGF+PA further confirmed that EGF may be a potent inducer of hyperproliferative/inflammatory pathways (IL1 signaling), an effect being more pronounced in the presence of PA.	Palmitic Acid	122-124	interleukin 1 alpha	Homo sapiens	221-224
33958662-2	2021	Palmitic acid (PA) is elevated in the sera of diabetics and stimulates the production of the DR-relevant cytokines by MC, including IL-1beta, which induces the production of itself and other inflammatory cytokines in the retina as well.	Palmitic Acid	15-17	interleukin 1 alpha	Homo sapiens	132-140
33958662-3	2021	In this study we propose that experimental elevation of cytochrome P450 epoxygenase (CYP)-derived epoxygenated fatty acids, epoxyeicosatrienoic acid (EET) and epoxydocosapentaenoic acid (EDP), will reduce PA- and IL-1beta-induced MC inflammation.	epoxygenated fatty acids	98-122	interleukin 1 alpha	Homo sapiens	213-221
33958662-3	2021	In this study we propose that experimental elevation of cytochrome P450 epoxygenase (CYP)-derived epoxygenated fatty acids, epoxyeicosatrienoic acid (EET) and epoxydocosapentaenoic acid (EDP), will reduce PA- and IL-1beta-induced MC inflammation.	epoxydocosapentaenoic acid	159-185	interleukin 1 alpha	Homo sapiens	213-221
33958662-3	2021	In this study we propose that experimental elevation of cytochrome P450 epoxygenase (CYP)-derived epoxygenated fatty acids, epoxyeicosatrienoic acid (EET) and epoxydocosapentaenoic acid (EDP), will reduce PA- and IL-1beta-induced MC inflammation.	2-ethyl-3,5-dimethylpyrazine	187-190	interleukin 1 alpha	Homo sapiens	213-221
33421881-6	2021	The levels of interleukin (IL)-1beta, IL-6, IL-8 and IL-13 were about 1.5 times higher in the PFOA-treated A549 and L-02 cells than in the controls.	perfluorooctanoic acid	94-98	interleukin 1 alpha	Homo sapiens	14-36
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	interleukin 1 alpha	Homo sapiens	66-74
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	interleukin 1 alpha	Homo sapiens	100-108
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	19(20)-EpDPE	24-33	interleukin 1 alpha	Homo sapiens	66-74
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	19(20)-EpDPE	24-33	interleukin 1 alpha	Homo sapiens	100-108
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	Palmitic Acid	58-60	interleukin 1 alpha	Homo sapiens	100-108
33958662-6	2021	Both epoxygenated fatty acids significantly decreased IL-8 expression in IL-1beta-induced MC and TNFalpha in PA-induced MC.	epoxygenated fatty acids	5-29	interleukin 1 alpha	Homo sapiens	73-81
33958662-7	2021	Interestingly, 11,12-EET and 19,20-EDP significantly increased TNFalpha in IL-1beta-treated MC.	11,12-epoxy-5,8,14-eicosatrienoic acid	15-24	interleukin 1 alpha	Homo sapiens	75-83
33958662-7	2021	Interestingly, 11,12-EET and 19,20-EDP significantly increased TNFalpha in IL-1beta-treated MC.	19(20)-EpDPE	29-38	interleukin 1 alpha	Homo sapiens	75-83
33958662-8	2021	GSK2256294, a soluble epoxide hydrolase (sEH) inhibitor, significantly reduced PA- and IL-1beta-stimulated MC cytokine expression.	N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide	0-10	interleukin 1 alpha	Homo sapiens	87-95
33958662-9	2021	11,12-EET and 19,20-EDP were also found to decrease PA- and IL-1beta-induced NFkappaB-dependent transcriptional activity.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	interleukin 1 alpha	Homo sapiens	60-68
33958662-9	2021	11,12-EET and 19,20-EDP were also found to decrease PA- and IL-1beta-induced NFkappaB-dependent transcriptional activity.	19(20)-EpDPE	14-23	interleukin 1 alpha	Homo sapiens	60-68
33877803-5	2021	Second, treatment with Ramelteon reduced expressions of IL-6, TNF-alpha, and IL-1beta.	ramelteon	23-32	interleukin 1 alpha	Homo sapiens	77-85
34025651-10	2021	During 8-12 weeks of ivacaftor-treatment, median values of IL-1beta and IL-6 significantly declined 2.29-fold (2.97 1.30 pg/mL), and 1.13-fold (6.48 5.72 pg/mL), respectively.	ivacaftor	21-30	interleukin 1 alpha	Homo sapiens	59-67
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Dinoprostone	132-148	interleukin 1 alpha	Homo sapiens	84-93
34017261-10	2021	HO-1 knockdown could abrogate the protective effects of XH in IL-1beta-treated chondrocytes.	xanthohumol	56-58	interleukin 1 alpha	Homo sapiens	62-70
34035660-8	2021	Results: In IL-1beta-primed cells, preincubation with Vanillin reduced IL-6, IL-8, COX-2, and iNOS expression and NO release, compared to IL-1beta-primed cells.	vanillin	54-62	interleukin 1 alpha	Homo sapiens	12-20
34035660-11	2021	Conclusion: Together, the results of this study highlight the anti-inflammatory and tissue repair ability of Vanillin in IL-1beta-primed HGF.	vanillin	109-117	interleukin 1 alpha	Homo sapiens	121-129
33945347-7	2021	Our results revealed that Evodiamine significantly decreased TNF-alpha, IL-6, and IL-1beta in BEAS-2B cells.	evodiamine	26-36	interleukin 1 alpha	Homo sapiens	82-90
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Dinoprostone	150-154	interleukin 1 alpha	Homo sapiens	84-93
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Reactive Oxygen Species	175-178	interleukin 1 alpha	Homo sapiens	84-93
34055194-4	2021	Methods: IL-1beta-induced ROS generation and chondrocyte apoptosis were determined by flow cytometry.	Reactive Oxygen Species	26-29	interleukin 1 alpha	Homo sapiens	9-17
34055194-6	2021	The involvement of NOX2 and mitogen-activated protein kinases (MAPKs) in IL-1beta-induced COX-2 and PGE2 expression was investigated using pharmacologic inhibitors and further analyzed by western blotting.	Dinoprostone	100-104	interleukin 1 alpha	Homo sapiens	73-81
34055194-10	2021	Conclusion: In OA chondrocytes, IL-1beta induced COX-2 and PGE2 expression via activation of NOX2, which led to ROS production and MAPK activation.	Dinoprostone	59-63	interleukin 1 alpha	Homo sapiens	32-40
34055194-10	2021	Conclusion: In OA chondrocytes, IL-1beta induced COX-2 and PGE2 expression via activation of NOX2, which led to ROS production and MAPK activation.	Reactive Oxygen Species	112-115	interleukin 1 alpha	Homo sapiens	32-40
33578236-9	2021	In animal trials, Tanshinone I and Tanshinone IIA/B significantly reduced MPO activity, and the levels of TNF-alpha, IL-1beta and IL-6 in serum and mammary gland tissues.	tanshinone	18-30	interleukin 1 alpha	Homo sapiens	117-125
33556876-5	2021	Our results showed that PCB2DG suppressed the production of IL-17, tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-6 with the suppression of transcription factors expression.	procyanidin B2-3,3'-di-O-gallate	24-30	interleukin 1 alpha	Homo sapiens	102-110
33578236-9	2021	In animal trials, Tanshinone I and Tanshinone IIA/B significantly reduced MPO activity, and the levels of TNF-alpha, IL-1beta and IL-6 in serum and mammary gland tissues.	tanshinone	35-49	interleukin 1 alpha	Homo sapiens	117-125
33556876-8	2021	These results suggested that PCB2DG first modulated TNF-alpha production by CD4+ T cells and then suppressed IL-1beta secretion from DCs, resulting in decreased IL-17 production.	procyanidin B2-3,3'-di-O-gallate	29-35	interleukin 1 alpha	Homo sapiens	109-117
33144047-10	2021	On the contrary, RHE treated with PM or TS after preconditioning by a semi-dry airflow show a lower increase in IL-1alpha, IL-8, and RANTES compared to preconditioning by a humid airflow.	Promethium	34-36	interleukin 1 alpha	Homo sapiens	112-121
33550164-7	2021	We found that TNF-alpha, IL-1beta, IL-6, and IL-8 were the four immune mediators that elevated in most of the samples derived from patients with CP/CPPS and the EAP models.	phosphorylethanolamine	161-164	interleukin 1 alpha	Homo sapiens	25-33
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Lead	0-2	interleukin 1 alpha	Homo sapiens	86-94
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Iron	8-10	interleukin 1 alpha	Homo sapiens	86-94
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Zinc	16-18	interleukin 1 alpha	Homo sapiens	86-94
33791002-8	2021	Compared with the lipopolysaccharide (LPS) group, the contents of IL-6, IL-1beta, TNF-alpha and PGE-2 in the culture supernatant were significantly declined in the leflunomide + LPS and intervention+LPS groups, as well as the mRNA expression levels of HIF-1alpha, VEGFA and TLR4.	Leflunomide	164-175	interleukin 1 alpha	Homo sapiens	72-80
33790996-7	2021	Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18.	barbituric acid	0-18	interleukin 1 alpha	Homo sapiens	128-136
33484091-7	2021	The anti-inflammatory effect of citral was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta, and the anti-inflammatory cytokine IL-10, in human myometrial explants stimulated with lipopolysaccharide (LPS).	citral	32-38	interleukin 1 alpha	Homo sapiens	156-178
33484091-9	2021	Citral caused a concentration-dependent increase in myometrial cAMP levels (p < .05) and a concentration-dependent decrease in LPS-induced TNFalpha and IL-1beta production, while IL-10 production increased significantly (p < .05).	citral	0-6	interleukin 1 alpha	Homo sapiens	152-160
33741378-5	2021	A decrease in TNF-alpha and IL-1beta production was also observed in LPS-tolerized macrophages induced by B-LPS at concentrations equal to and higher than that of E-LPS.	b-lps	106-111	interleukin 1 alpha	Homo sapiens	28-36
33582592-9	2021	The GMSC-Exos group showed lower Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and cluster of differentiation 86 (CD86) expression levels than the high-lipid group, and the highest levels of Interleukin-10 (IL-10) among all groups.	gmsc	4-8	interleukin 1 alpha	Homo sapiens	115-123
33790996-7	2021	Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18.	Ketamine	20-28	interleukin 1 alpha	Homo sapiens	128-136
33790996-7	2021	Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18.	Propofol	33-41	interleukin 1 alpha	Homo sapiens	128-136
33636560-9	2021	Molecular analyses indicated that the protection mediated by L-Ctl against LPS-evoked sepsis targeted the TLR4/ERK/JNK/p38-MAPK pathway, regulating NFkB p65, NFkB p52 and COX2 expression and repressing the mRNA expression levels of the LPS-induced proinflammatory factors IL-1beta, IL-6, TNF-alpha and NOS2.	l-ctl	61-66	interleukin 1 alpha	Homo sapiens	272-280
33741378-5	2021	A decrease in TNF-alpha and IL-1beta production was also observed in LPS-tolerized macrophages induced by B-LPS at concentrations equal to and higher than that of E-LPS.	e-lps	163-168	interleukin 1 alpha	Homo sapiens	28-36
34025139-8	2021	However, the treatment of RGE or SF in HaCaT cells in the presence of poly I:C, a toll-like receptor (TLR) 3 ligand, before UV exposure elicited the inhibition of the IL-1beta secretion.	Poly I	70-76	interleukin 1 alpha	Homo sapiens	167-175
32955700-9	2021	CONCLUSION: Serum IL-1beta, IL-6, and IL-17A serve as indicators for predicting clinical response to celecoxib in AS patients, which may assist with the optimization of personalized treatment.	Celecoxib	101-110	interleukin 1 alpha	Homo sapiens	18-26
34025139-8	2021	However, the treatment of RGE or SF in HaCaT cells in the presence of poly I:C, a toll-like receptor (TLR) 3 ligand, before UV exposure elicited the inhibition of the IL-1beta secretion.	Carbon	41-42	interleukin 1 alpha	Homo sapiens	167-175
34025139-10	2021	Conclusion: RGE and its saponins inhibit IL-1beta secretion in response to UV exposure in both keratinocytes and macrophages.	Saponins	24-32	interleukin 1 alpha	Homo sapiens	41-49
33713324-5	2021	In the present study, we observed that FK866 (a specific noncompetitive NAMPT inhibitor) dose-dependently inhibited lipopolysaccharide (LPS)-induced proinflammatory mediator (interleukin (IL)-6, IL-1beta, inducible nitric oxide synthase, nitric oxide and reactive species) level increase in BV2 microglia cultures.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	39-44	interleukin 1 alpha	Homo sapiens	195-203
33289070-12	2021	Activation of SIRT1 by resveratrol had a neuroprotective effect, along with decreased levels of Ac-p65, IL-1beta, TNF-alpha, and apoptosis after ICH.	Resveratrol	23-34	interleukin 1 alpha	Homo sapiens	104-112
33417223-5	2021	We found that microglia exposed to cocaine exhibited significant induction of NLRP3 and mature IL-1beta expression.	Cocaine	35-42	interleukin 1 alpha	Homo sapiens	95-103
33667621-9	2021	RESULTS: and Discussion: Effects of PMA on upregulation of adherence, lipopolysaccharide-triggered IL-1beta, and migration ability of THP-1 cells were consistent with NO concentrations.	20-oxo-20-deoxy-12-myristate 13-acetate	36-39	interleukin 1 alpha	Homo sapiens	99-107
33902703-0	2021	Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1beta production.	Uric Acid	54-63	interleukin 1 alpha	Homo sapiens	72-80
33675175-16	2021	MiR-671-5p knockdown attenuated the influence of circ-IQGAP1 interference on IL-1beta-caused chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation.	CHEMBL3740941	8-10	interleukin 1 alpha	Homo sapiens	77-85
33930279-5	2021	IL-1beta, IL-6 and osteopontin (OPN) were more strongly inhibited by SAC than in colchicine.	Colchicine	81-91	interleukin 1 alpha	Homo sapiens	0-8
33931497-10	2021	LPS on its own triggered release of TNF-alpha, whereas release of IL-1beta required costimulation by ATP.	Adenosine Triphosphate	101-104	interleukin 1 alpha	Homo sapiens	66-74
33926561-0	2021	Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1beta-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	66-74
33926561-5	2021	Here, we evaluated modulatory effects of curcumin-primed human (h)BMSC-derived EVs (Cur-EVs) on IL-1beta stimulated human osteoarthritic chondrocytes (OA-CH).	Curcumin	41-49	interleukin 1 alpha	Homo sapiens	96-104
33926561-14	2021	RESULTS: Cur-EVs promoted viability and reduced apoptosis of IL-1beta-stimulated OA-CH and attenuated IL-1beta-induced inhibition of migration.	cur-evs	9-16	interleukin 1 alpha	Homo sapiens	61-69
33926561-14	2021	RESULTS: Cur-EVs promoted viability and reduced apoptosis of IL-1beta-stimulated OA-CH and attenuated IL-1beta-induced inhibition of migration.	cur-evs	9-16	interleukin 1 alpha	Homo sapiens	102-110
33926561-15	2021	Furthermore, Cur-EVs increased gene expression of BCL2, ACAN, SOX9, and COL2A1 and decreased gene expression of IL1B, IL6, MMP13, and COL10A1 in IL-1beta-stimulated OA-CH.	cur-evs	13-20	interleukin 1 alpha	Homo sapiens	145-153
33926561-16	2021	In addition, phosphorylation of Erk1/2, PI3K/Akt, and p38 MAPK, induced by IL-1beta, is prevented by Cur-EVs.	cur-evs	101-108	interleukin 1 alpha	Homo sapiens	75-83
33926561-18	2021	CONCLUSION: Cur-EVs alleviated IL-1beta-induced catabolic effects on OA-CH by promoting viability and migration, reducing apoptosis and phosphorylation of Erk1/2, PI3K/Akt, and p38 MAPK thereby modulating pro-inflammatory signaling pathways.	cur-evs	12-19	interleukin 1 alpha	Homo sapiens	31-39
33998900-7	2021	Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone.	Cannabidiol	224-227	interleukin 1 alpha	Homo sapiens	38-60
33926523-14	2021	In vivo, injection of human calcifications or synthetic hydroxyapatite in the air pouch led to a significant increase in membrane thickness although significant overexpression of IL-1beta was only observed for synthetic hydroxyapatite.	Durapatite	56-70	interleukin 1 alpha	Homo sapiens	179-187
33926523-14	2021	In vivo, injection of human calcifications or synthetic hydroxyapatite in the air pouch led to a significant increase in membrane thickness although significant overexpression of IL-1beta was only observed for synthetic hydroxyapatite.	Durapatite	220-234	interleukin 1 alpha	Homo sapiens	179-187
33926523-15	2021	CONCLUSIONS: As synthetic hydroxyapatite, human calcifications were able to induce an inflammatory response resulting in the production of IL-1beta after NF-kB activation and through NLRP3 inflammasome.	Durapatite	26-40	interleukin 1 alpha	Homo sapiens	139-147
33913531-9	2021	In conclusion, V.cholerae TcpA induces statistically significant dose-dependent stimulatory effect on TNFalpha, IL-1 and IL-8 pro-inflammatory cytokines expression.	chlorfenac	26-30	interleukin 1 alpha	Homo sapiens	112-116
33913256-6	2021	Independent of MEFV genotype, unstimulated FMF monocytes from colchicine treated patients secreted lower amounts of IL1Ralpha as compared to healthy donors (p<0.05) and displayed decreased ratios of IL1Ralpha/IL1beta (p<0.05), suggesting a reduced anti-inflammatory capacity.	Colchicine	62-72	interleukin 1 alpha	Homo sapiens	209-216
33902703-4	2021	In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils.	Uric Acid	49-65	interleukin 1 alpha	Homo sapiens	81-89
33902703-4	2021	In this study, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1beta secretion using human neutrophils.	Uric Acid	67-70	interleukin 1 alpha	Homo sapiens	81-89
33902621-0	2021	Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale.	rph-104	28-35	interleukin 1 alpha	Homo sapiens	0-13
33902621-3	2021	We postulate that the use of the drug RPH-104, which selectively binds and inactivates both alpha and beta isoforms of IL-1 will lead to a decrease in the severity of the inflammatory response which will be reflected by decrease in the concentration of hsCRP, as well as the rate of fatal outcomes, frequency of new cases of HF, changes in levels of brain natriuretic peptide (BNP) and changes in structural and functional echocardiographic parameters.	rph-104	38-45	interleukin 1 alpha	Homo sapiens	119-123
33962830-9	2022	RESULTS: Hemin improved burn-induced renal histological damage and dysfunction, and this beneficial effect was related to reduced renal oxidative stress and the release of proinflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6 and intracellular adhesion molecule-1 (ICAM-1).	Hemin	9-14	interleukin 1 alpha	Homo sapiens	248-270
33460754-8	2021	RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid.	[(1s)-2-(Methoxycarbonylamino)-1-Phenyl-Ethoxy]-Propyl-Phosphinic Acid	9-12	interleukin 1 alpha	Homo sapiens	113-121
33460754-8	2021	RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid.	Uric Acid	84-87	interleukin 1 alpha	Homo sapiens	113-121
33718825-5	2021	Using genetic and pharmacological inhibition, we show that the induction of mature IL-1beta is through a non-classical pathway dependent upon caspase-1, caspase-8, the NLRP3 inflammasome, potassium efflux, and autophagy while being independent of TRIF (TICAM1), vitamin D3, and pyroptosis.	Potassium	188-197	interleukin 1 alpha	Homo sapiens	83-91
33718825-5	2021	Using genetic and pharmacological inhibition, we show that the induction of mature IL-1beta is through a non-classical pathway dependent upon caspase-1, caspase-8, the NLRP3 inflammasome, potassium efflux, and autophagy while being independent of TRIF (TICAM1), vitamin D3, and pyroptosis.	Cholecalciferol	262-272	interleukin 1 alpha	Homo sapiens	83-91
34056329-5	2021	Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1).	Telmisartan	15-26	interleukin 1 alpha	Homo sapiens	137-145
33886081-4	2021	Western blotting, qRT-PCR and ELISA also showed that chloroquine (CQ) could up-regulate the expression of p62 through impairing autophagy and induce the pyroptosis of macrophages treated by ox-LDL, as evidenced by the decrease of cell viability and membrane integrity, and the increase of pro-caspase-1, GSDMD, and proinflammatory factors IL-1beta and IL-18.	Chloroquine	53-64	interleukin 1 alpha	Homo sapiens	339-347
33886081-4	2021	Western blotting, qRT-PCR and ELISA also showed that chloroquine (CQ) could up-regulate the expression of p62 through impairing autophagy and induce the pyroptosis of macrophages treated by ox-LDL, as evidenced by the decrease of cell viability and membrane integrity, and the increase of pro-caspase-1, GSDMD, and proinflammatory factors IL-1beta and IL-18.	Chloroquine	66-68	interleukin 1 alpha	Homo sapiens	339-347
33919212-6	2021	Also, plasma glutathione concentrations were positively associated with ex vivo IL-1beta production, a biomarker of trained immunity, produced by monocytes of BCG-vaccinated individuals.	Glutathione	13-24	interleukin 1 alpha	Homo sapiens	80-88
33900308-6	2021	Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells.	syringic acid	0-13	interleukin 1 alpha	Homo sapiens	92-114
33900308-6	2021	Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells.	cyanidin 3-O-glucopyranoside	18-27	interleukin 1 alpha	Homo sapiens	92-114
33902703-9	2021	However, MSU stimulation induced IL-1beta secretion from CIRP-primed neutrophils in a dose-dependent manner.	Uric Acid	9-12	interleukin 1 alpha	Homo sapiens	33-41
33919308-6	2021	Under both oxygen conditions cells were exposed to proinflammatory cytokines involved significantly in acute inflammation, i.e., IFNgamma, TNFalpha and IL-1beta at different concentrations.	Oxygen	11-17	interleukin 1 alpha	Homo sapiens	152-160
33902703-10	2021	This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3.	Uric Acid	5-8	interleukin 1 alpha	Homo sapiens	17-25
33902703-10	2021	This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3.	Uric Acid	5-8	interleukin 1 alpha	Homo sapiens	109-117
33902703-13	2021	CONCLUSIONS: Our data indicate that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1beta induction as a priming stimulus for NLRP3 inflammasome in human neutrophils.	Uric Acid	82-91	interleukin 1 alpha	Homo sapiens	107-115
33892379-7	2021	Importantly, in vivo experiments showed that BA markedly reduces the secretion of IL-1beta to suppress NLRP3 inflammasome in the LPS-induced inflammation and MSU-challenged peritonitis model.	brevilin A	45-47	interleukin 1 alpha	Homo sapiens	82-90
33981845-7	2021	In this study, levels of TUG1 and FUT4 were distinctly upregulated, but miR-320c level significantly decreased in OA tissues and chondrocytes derived from OA tissues as well as in IL-1beta-stimulated C28/I2 cells.	mir-320c	72-80	interleukin 1 alpha	Homo sapiens	180-188
33876818-11	2021	Moreover, butyric acid alleviated CIH-induced cell proliferation, lipid formation and inflammatory status and promoted cell apoptosis through regulating related genes including p21, PPARgamma, C/EBPa, IL-1beta, IL-6, TLR4, caspase-8 and caspase-3.	Butyric Acid	10-22	interleukin 1 alpha	Homo sapiens	201-209
33994056-11	2021	HJ105 decreased TXNIP expression, suppressing NLRP3 inflammasome activation in the hippocampus, which in turn counteracted the upregulation of IL-1beta and TNF-alpha.	hj105	0-5	interleukin 1 alpha	Homo sapiens	143-151
33921615-12	2021	In addition, lipoxin A4 inhibited the infiltration of neutrophils and the production of cytokines and pro-inflammatory chemokines, such as interleukin (Il-1beta, Il-6, Il-8) and tumor necrosis factor-alpha (TNF-alpha).	lipoxin A4	13-23	interleukin 1 alpha	Homo sapiens	152-160
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	3-(4-methylphenylsulfonyl)-2-propenenitrile	140-150	interleukin 1 alpha	Homo sapiens	91-99
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	3-(4-methylphenylsulfonyl)-2-propenenitrile	140-150	interleukin 1 alpha	Homo sapiens	221-229
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	155-164	interleukin 1 alpha	Homo sapiens	91-99
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	155-164	interleukin 1 alpha	Homo sapiens	221-229
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	172-177	interleukin 1 alpha	Homo sapiens	221-229
33872750-13	2021	LHQW (1000 mg/kg/d) administered prophylactically significantly decreased the lung viral titers (P<0.05), slightly downregulated IL-6 but TNF-alpha, IL-1beta levels and improved lung pathological inflammation including neutrophil infiltration, necrosis, which is consistent with the expression of inflammatory factors.	lhqw	0-4	interleukin 1 alpha	Homo sapiens	149-157
33861768-10	2021	Among children with infection at enrollment, IL-1 production by PBMCs stimulated with SEA was higher (P = 0.03) in the maternal PZQ group compared to placebo.	Praziquantel	128-131	interleukin 1 alpha	Homo sapiens	45-49
33861800-6	2021	Using a combination of siRNA knockdowns in monocyte derived macrophages (MDMs) of different TLRs and NLRs as well as chemical inhibition, it was demonstrated that HIV Vpu could trigger inflammasome activation via TLR4/NLRP3 leading to IL-1beta/IL-18 secretion.	VPU	167-170	interleukin 1 alpha	Homo sapiens	235-243
33861386-15	2022	mRNA expression levels of IL-6 and IL-1beta were lower in curcumin-treated samples as compared to PHA alone, both amongst pSS and control groups (p = 0.0009 and p = 0.04, respectively).	Curcumin	58-66	interleukin 1 alpha	Homo sapiens	35-43
33861386-18	2022	Curcumin also suppressed PHA-induced mRNA expression levels of IL-6 and IL-1beta in MSG tissue of patients with pSS and controls.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	72-80
33741688-3	2021	In this study, we show that extracellular heme engages the human inflammatory caspases, caspase-1, caspase-4, and caspase-5, resulting in the release of IL-1beta.	Heme	42-46	interleukin 1 alpha	Homo sapiens	153-161
34017439-10	2021	Compared with the controls, the DMED group had lower levels of NF-kappaB and TLR3 at T2-T4, lower levels of sCr, IL-1beta, and TNF-alpha at T3-T4, and lower incidence of AKI at T3 (all P<=0.01).	Dexmedetomidine	32-36	interleukin 1 alpha	Homo sapiens	113-121
33936102-9	2021	Importantly, caproic acid diminished the production of IL-32, IL-18, and IL-1beta in human PBMCs in response to bacterial LPS stimulation.	hexanoic acid	13-25	interleukin 1 alpha	Homo sapiens	73-81
33741688-4	2021	Heme-induced IL-1beta release was further increased in macrophages from patients with sickle cell disease.	Heme	0-4	interleukin 1 alpha	Homo sapiens	13-21
33741688-6	2021	Furthermore, we show that both caspase-4 and caspase-5 are essential for heme-induced IL-1beta release, whereas caspase-4 is the primary contributor to heme-induced cell death.	Heme	73-77	interleukin 1 alpha	Homo sapiens	86-94
33851870-0	2021	Lung Immune Tone via Gut-Lung Axis: Gut-derived LPS and Short-chain Fatty Acids" immunometabolic regulation of Lung IL-1beta, FFAR2 and FFAR3 Expression.	Fatty Acids, Volatile	56-79	interleukin 1 alpha	Homo sapiens	116-124
33852854-4	2021	Endogenous GSDME activation permitted sublytic, continuous interleukin-1beta (IL-1beta) release and membrane leakage, even in GSDMD-sufficient cells, whereas ectopic expression led to pyroptosis with GSDME oligomerization and complete liberation of IL-1beta akin to GSDMD pyroptosis.	gsdme	11-16	interleukin 1 alpha	Homo sapiens	249-257
33852854-4	2021	Endogenous GSDME activation permitted sublytic, continuous interleukin-1beta (IL-1beta) release and membrane leakage, even in GSDMD-sufficient cells, whereas ectopic expression led to pyroptosis with GSDME oligomerization and complete liberation of IL-1beta akin to GSDMD pyroptosis.	gsdme	11-16	interleukin 1 alpha	Homo sapiens	78-86
33852854-6	2021	Our study thus identifies GSDME as a conduit for IL-1beta release independent of its ability to cause cell death.	gsdme	26-31	interleukin 1 alpha	Homo sapiens	49-57
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	interleukin 1 alpha	Homo sapiens	164-172
33850164-5	2021	Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1beta, IL-6, IL-8 and IFN-gamma, and chemokines such as CXCL10, CCL2, CCL3 and CCL4.	Cromolyn Sodium	0-8	interleukin 1 alpha	Homo sapiens	152-160
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	interleukin 1 alpha	Homo sapiens	186-194
33912037-8	2021	Moreover, 3"-SL significantly inhibited the apoptotic process, as indicated by the downregulation of the pro-apoptotic protein Bax, upregulation of the anti-apoptotic protein Bcl-2 expression, and significant reduction in the number of TUNEL-positive cells in the IL-1beta-treated chondrocytic cells.	3'-sialyllactose	10-15	interleukin 1 alpha	Homo sapiens	264-272
33921194-8	2021	Furthermore, when macrophages were cocultured with lymphocytes, decitabine induced a reduction in the release of inflammatory cytokines such as IL-1beta, TNF-alpha, and IFN-gamma, maintaining IL-10 production, suggesting that decitabine could potentialize M2 polarization and might be considered as a therapeutic against the exacerbated immune response.	Decitabine	64-74	interleukin 1 alpha	Homo sapiens	144-152
33839697-5	2021	LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1).	sacubitril and valsartan sodium hydrate drug combination	0-6	interleukin 1 alpha	Homo sapiens	112-130
33839697-5	2021	LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1).	sacubitril and valsartan sodium hydrate drug combination	0-6	interleukin 1 alpha	Homo sapiens	132-141
33897442-12	2021	In parallel, NaB treatment could enhance the activation of autophagy, increase autophagic flux, decrease extracellular matrix degradation, and reduce apoptosis by restraining inflammation, ROS production, and cell cycle arrest in IL-1beta-treated chondrocytes.	nab	13-16	interleukin 1 alpha	Homo sapiens	230-238
33897442-12	2021	In parallel, NaB treatment could enhance the activation of autophagy, increase autophagic flux, decrease extracellular matrix degradation, and reduce apoptosis by restraining inflammation, ROS production, and cell cycle arrest in IL-1beta-treated chondrocytes.	Reactive Oxygen Species	189-192	interleukin 1 alpha	Homo sapiens	230-238
33835494-2	2021	The anion Cl- , acting as a second messenger, stimulates the secretion of interleukin-1beta (IL-1beta), which starts an autocrine positive feedback loop.	Anions	4-9	interleukin 1 alpha	Homo sapiens	93-101
33835494-5	2021	The CASP1 inhibitor VX-765 and the NLRP3 inflammasome inhibitor MCC950 completely blocked the Cl- -stimulated IL-1beta mRNA expression and partially the IL-1beta secretion.	belnacasan	20-26	interleukin 1 alpha	Homo sapiens	110-118
33835494-5	2021	The CASP1 inhibitor VX-765 and the NLRP3 inflammasome inhibitor MCC950 completely blocked the Cl- -stimulated IL-1beta mRNA expression and partially the IL-1beta secretion.	belnacasan	20-26	interleukin 1 alpha	Homo sapiens	153-161
33835494-8	2021	More importantly, the serum/glucocorticoid regulated kinase 1 (SGK1) inhibitor GSK650394, or its shRNAs, completely abrogated the IL-1beta mRNA response to Cl- and the IL-1beta secretion, interrupting the autocrine IL-1beta loop.	2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid	79-88	interleukin 1 alpha	Homo sapiens	130-138
33835494-8	2021	More importantly, the serum/glucocorticoid regulated kinase 1 (SGK1) inhibitor GSK650394, or its shRNAs, completely abrogated the IL-1beta mRNA response to Cl- and the IL-1beta secretion, interrupting the autocrine IL-1beta loop.	2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid	79-88	interleukin 1 alpha	Homo sapiens	168-176
33835494-8	2021	More importantly, the serum/glucocorticoid regulated kinase 1 (SGK1) inhibitor GSK650394, or its shRNAs, completely abrogated the IL-1beta mRNA response to Cl- and the IL-1beta secretion, interrupting the autocrine IL-1beta loop.	2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid	79-88	interleukin 1 alpha	Homo sapiens	168-176
33508280-9	2021	In addition, COP treatment remarkably suppressed the levels of colonic myeloperoxidase (MPO), adhesion molecules and pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-17), while enhanced IL-10 and TGF-beta.	coptisine	13-16	interleukin 1 alpha	Homo sapiens	167-175
33912037-5	2021	3"-SL potently suppressed IL-1beta-induced oxidative stress by increasing the levels of enzymatic antioxidants.	3'-sialyllactose	0-5	interleukin 1 alpha	Homo sapiens	26-34
33912037-6	2021	3"-SL significantly reversed the IL-1beta mediated expression levels of reactive oxygen species in IL-1beta-stimulated chondrocytic cells.	Oxygen	81-87	interleukin 1 alpha	Homo sapiens	33-41
33912037-6	2021	3"-SL significantly reversed the IL-1beta mediated expression levels of reactive oxygen species in IL-1beta-stimulated chondrocytic cells.	Oxygen	81-87	interleukin 1 alpha	Homo sapiens	99-107
33823789-11	2021	Expression of the inflammatory cytokines IL-1beta, IL-18 and TNF-alpha was significantly increased in cardiac fibroblasts after H/R and was attenuated by dexmedetomidine treatment.	Dexmedetomidine	154-169	interleukin 1 alpha	Homo sapiens	41-49
33889075-4	2021	The available data indicates that ATP and glutamate can induce the release of pro inflammatory factors TNF (tumor necrosis factor), IL-1beta (interleukin 1 beta), and NO (nitric oxide) from microglia.	Adenosine Triphosphate	34-37	interleukin 1 alpha	Homo sapiens	132-140
33889075-4	2021	The available data indicates that ATP and glutamate can induce the release of pro inflammatory factors TNF (tumor necrosis factor), IL-1beta (interleukin 1 beta), and NO (nitric oxide) from microglia.	Glutamic Acid	42-51	interleukin 1 alpha	Homo sapiens	132-140
33821497-5	2021	We found that moderate mechanical stress reduced the IL-1beta-induced apoptosis by maintaining mitochondrial function and scavenging the reactive oxygen species, while excessive mechanical stress induced strong mitochondrial dysfunction and apoptosis.	Reactive Oxygen Species	137-160	interleukin 1 alpha	Homo sapiens	53-61
33583045-10	2021	Our network meta-analysis suggests that EtOH exposure may augment the effects of SARS-CoV-2 infection on hepatic fibrosis signaling pathway, cellular metabolism and homeostasis, inflammation, and neuroinflammation, and that EtOH may enhance the activity of key meditators including cytokines, such as IL1beta, IL6, and TNF, and transcription factors, such as JUN and STAT, while inhibiting the activity of anti-inflammatory mediators including glucocorticoid receptor.	Ethanol	40-44	interleukin 1 alpha	Homo sapiens	301-308
33085904-5	2021	This showed that acetate, propionate and butyrate were all anti-inflammatory to an IL-1beta inflammatory stimulus.	Acetates	17-24	interleukin 1 alpha	Homo sapiens	83-91
33085904-5	2021	This showed that acetate, propionate and butyrate were all anti-inflammatory to an IL-1beta inflammatory stimulus.	Propionates	26-36	interleukin 1 alpha	Homo sapiens	83-91
33085904-5	2021	This showed that acetate, propionate and butyrate were all anti-inflammatory to an IL-1beta inflammatory stimulus.	Butyrates	41-49	interleukin 1 alpha	Homo sapiens	83-91
33085904-8	2021	SCFAs, products of microbial metabolism of complex carbohydrates of breastmilk oligosaccharides, have been found with this study to induce an anti-IL-1beta response that is associated with an upregulation of tight junctions and mucus genes in epithelial cells (H4 cells).	Fatty Acids, Volatile	0-5	interleukin 1 alpha	Homo sapiens	147-155
33085904-8	2021	SCFAs, products of microbial metabolism of complex carbohydrates of breastmilk oligosaccharides, have been found with this study to induce an anti-IL-1beta response that is associated with an upregulation of tight junctions and mucus genes in epithelial cells (H4 cells).	Carbohydrates	51-64	interleukin 1 alpha	Homo sapiens	147-155
33085904-8	2021	SCFAs, products of microbial metabolism of complex carbohydrates of breastmilk oligosaccharides, have been found with this study to induce an anti-IL-1beta response that is associated with an upregulation of tight junctions and mucus genes in epithelial cells (H4 cells).	Oligosaccharides	79-95	interleukin 1 alpha	Homo sapiens	147-155
32506663-7	2021	MAPC-treated kidneys demonstrated improved urine-output (p=0.009), decreased expression of injury biomarker NGAL (p=0.012), improved microvascular perfusion on contrast enhanced ultrasound (cortex p=0.019, medulla p=0.001), downregulation of IL-1beta (p=0.050) and upregulation of IL-10 (p<0.047) and Indolamine-2, 3-dioxygenase (p=0.050).	mapc	0-4	interleukin 1 alpha	Homo sapiens	242-250
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	interleukin 1 alpha	Homo sapiens	55-77
33123835-7	2021	miR-125b-5p was markedly upregulated in both human lumbar degenerative NP specimens and IL-1beta-treated NP cells.	mir-125b-5p	0-11	interleukin 1 alpha	Homo sapiens	88-96
33123835-9	2021	The levels of TNF-alpha and IL-6 were inhibited in IL-1beta-treated NP cells transfected with miR-125b-5p inhibitor.	mir-125b	94-102	interleukin 1 alpha	Homo sapiens	51-59
33123835-10	2021	Moreover, miR-125b-5p inhibitor increased NP cell viability, prevented apoptosis and repressed the apoptotic peptidase activating factor 1/caspase 9 pathway in IL-1beta-treated NP cells.	mir-125b-5p	10-21	interleukin 1 alpha	Homo sapiens	160-168
33254051-0	2021	Ultrasensitive detection of interleukin 1alpha using 3-phosphonopropionic acid modified FTO surface as an effective platform for disposable biosensor fabrication.	beta-phosphonopropionic acid	53-78	interleukin 1 alpha	Homo sapiens	28-46
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	carboxyalkylphosphonic acid	29-56	interleukin 1 alpha	Homo sapiens	140-158
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	carboxyalkylphosphonic acid	29-56	interleukin 1 alpha	Homo sapiens	160-169
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	Fluorine	65-73	interleukin 1 alpha	Homo sapiens	140-158
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	Fluorine	65-73	interleukin 1 alpha	Homo sapiens	160-169
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	stannic oxide	80-89	interleukin 1 alpha	Homo sapiens	140-158
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	stannic oxide	80-89	interleukin 1 alpha	Homo sapiens	160-169
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	L 685458	91-94	interleukin 1 alpha	Homo sapiens	140-158
33254051-1	2021	In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1alpha (IL-1alpha) immunosensor.	L 685458	91-94	interleukin 1 alpha	Homo sapiens	160-169
33254051-2	2021	For this aim, anti-IL-1alpha antibodies were attached on the 3-phosphonopropionic acid (PHP) modified FTO surface covalently.	beta-phosphonopropionic acid	61-86	interleukin 1 alpha	Homo sapiens	19-28
33254051-2	2021	For this aim, anti-IL-1alpha antibodies were attached on the 3-phosphonopropionic acid (PHP) modified FTO surface covalently.	php	88-91	interleukin 1 alpha	Homo sapiens	19-28
33409657-12	2021	H2S alone and H2S followed by ODE exposure increased the levels of IL-1beta.	Deuterium	0-3	interleukin 1 alpha	Homo sapiens	67-75
33409657-12	2021	H2S alone and H2S followed by ODE exposure increased the levels of IL-1beta.	Deuterium	14-17	interleukin 1 alpha	Homo sapiens	67-75
33916321-9	2021	Both basal and IL-1beta-mediated PGE2 secretion was greater in MALAT1 depleted osteoblasts.	Dinoprostone	33-37	interleukin 1 alpha	Homo sapiens	15-23
32875512-8	2021	Additionally, plasma IL-1beta and IL-9 levels were increased along with those of blood uric acid (R2 = 0.4116 and R2 = 0.4150, respectively, P < 0.001).	Uric Acid	87-96	interleukin 1 alpha	Homo sapiens	21-29
33931964-0	2021	FABP4 deactivates NF-kappaB-IL1alpha pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression.	atpb	63-67	interleukin 1 alpha	Homo sapiens	28-36
33931964-7	2021	The consequently decreased ATP levels could deactivate NF-kappaB/RelA-IL1alpha pathway, which subsequently results in macrophages reprogrammed to an anti-inflammatory phenotype.	Adenosine Triphosphate	27-30	interleukin 1 alpha	Homo sapiens	70-78
33931964-10	2021	Our findings suggest that FABP4-mediated macrophages may promote proliferation and migration phenotypes in NB cells through deactivating NF-kappaB-IL1alpha pathway by ubiquitinating ATPB.	atpb	182-186	interleukin 1 alpha	Homo sapiens	147-155
33508533-6	2021	Furthermore, Cd exposure upregulated the expression levels of TNF-alpha, IL-1beta and IL-6 in pancreatic beta-cells and elevated the TNF-alpha, IL1-beta and IL-6 levels in the serum and pancreas.	Cadmium	13-15	interleukin 1 alpha	Homo sapiens	73-81
33508533-6	2021	Furthermore, Cd exposure upregulated the expression levels of TNF-alpha, IL-1beta and IL-6 in pancreatic beta-cells and elevated the TNF-alpha, IL1-beta and IL-6 levels in the serum and pancreas.	Cadmium	13-15	interleukin 1 alpha	Homo sapiens	144-152
33516901-4	2021	TCS at concentrations between 0.05-5 microM consistently increased the secretion of IL-1beta, IL-6, and TNFalpha within 24 h of exposure and the increases often maintained out to 6 days of exposure.	Triclosan	0-3	interleukin 1 alpha	Homo sapiens	84-92
33516901-5	2021	TCS also induced increases in IFNgamma secretion, however the increases were most consistent after 48 h of exposure rather than within 24 h. Additionally, a role for both p44/42 and p38 MAPK in TCS-stimulated increases in IL-1beta was seen in cells from some donors.	Triclosan	0-3	interleukin 1 alpha	Homo sapiens	222-230
33516901-5	2021	TCS also induced increases in IFNgamma secretion, however the increases were most consistent after 48 h of exposure rather than within 24 h. Additionally, a role for both p44/42 and p38 MAPK in TCS-stimulated increases in IL-1beta was seen in cells from some donors.	Triclosan	194-197	interleukin 1 alpha	Homo sapiens	222-230
33680110-0	2021	Oroxylin A attenuates IL-1beta-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	interleukin 1 alpha	Homo sapiens	22-30
33680110-8	2021	The results demonstrated that OrA significantly attenuated the upregulation of inducible nitric oxide synthase and cyclooxygenase 2 by IL-1beta at both protein and mRNA levels.	Nitric Oxide	89-101	interleukin 1 alpha	Homo sapiens	135-143
33717236-3	2021	The aim of the present study was to investigate the role of IL-1beta in paclitaxel sensitivity of NSCLC cells and elucidate the underlying mechanism.	Paclitaxel	72-82	interleukin 1 alpha	Homo sapiens	60-68
33717236-5	2021	Subsequently, Cell Counting Kit-8 assay and flow cytometry revealed that IL-1beta weakened the sensitivity of A549 cells to paclitaxel.	Paclitaxel	124-134	interleukin 1 alpha	Homo sapiens	73-81
33717236-6	2021	It was subsequently demonstrated that IL-1beta induced A549 cell autophagy, while tunicamycin-induced autophagy increased the IL-1beta expression level and weakened paclitaxel sensitivity.	Tunicamycin	82-93	interleukin 1 alpha	Homo sapiens	126-134
33717236-7	2021	Thus, the results revealed that IL-1beta reduced the sensitivity to paclitaxel in A549 cells by promoting autophagy and suggested that IL-1beta may be of value for improving the therapeutic efficacy of paclitaxel chemotherapy in NSCLC.	Paclitaxel	68-78	interleukin 1 alpha	Homo sapiens	32-40
33717236-7	2021	Thus, the results revealed that IL-1beta reduced the sensitivity to paclitaxel in A549 cells by promoting autophagy and suggested that IL-1beta may be of value for improving the therapeutic efficacy of paclitaxel chemotherapy in NSCLC.	Paclitaxel	68-78	interleukin 1 alpha	Homo sapiens	135-143
33717236-7	2021	Thus, the results revealed that IL-1beta reduced the sensitivity to paclitaxel in A549 cells by promoting autophagy and suggested that IL-1beta may be of value for improving the therapeutic efficacy of paclitaxel chemotherapy in NSCLC.	Paclitaxel	202-212	interleukin 1 alpha	Homo sapiens	32-40
33717236-7	2021	Thus, the results revealed that IL-1beta reduced the sensitivity to paclitaxel in A549 cells by promoting autophagy and suggested that IL-1beta may be of value for improving the therapeutic efficacy of paclitaxel chemotherapy in NSCLC.	Paclitaxel	202-212	interleukin 1 alpha	Homo sapiens	135-143
33732318-0	2021	Combination of baicalein and miR-106a-5p mimics significantly alleviates IL-1beta-induced inflammatory injury in CHON-001 cells.	baicalein	15-24	interleukin 1 alpha	Homo sapiens	73-81
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	interleukin 1 alpha	Homo sapiens	306-314
33641076-4	2021	In vivo, Dex markedly reduced pulmonary edema induced by LPS through promoting AFC, prevented LPS-induced downregulation of alpha-, beta-, and gamma-ENaC expression, attenuated inflammatory cell infiltration in lung tissue, reduced the concentrations of TNF-alpha, IL-1beta, and IL-6, and increased concentrations of IL-10 in bronchoalveolar lavage fluid (BALF).	Dexmedetomidine	9-12	interleukin 1 alpha	Homo sapiens	265-273
33792188-11	2021	In addition, production of IL-1beta and IL-33, pro-inflammatory cytokines, was modulated by DeltaNp63.	deltanp63	92-101	interleukin 1 alpha	Homo sapiens	27-35
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Carbon	32-38	interleukin 1 alpha	Homo sapiens	247-255
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Reactive Oxygen Species	89-112	interleukin 1 alpha	Homo sapiens	247-255
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Reactive Oxygen Species	114-117	interleukin 1 alpha	Homo sapiens	247-255
32779379-8	2021	Incubation of hNECs with N-acetyl-L-cysteine (NAC) significantly attenuated BC +- pollen-induced expression of ROS, NLRP3, and IL-1beta.	Acetylcysteine	25-44	interleukin 1 alpha	Homo sapiens	127-135
32779379-8	2021	Incubation of hNECs with N-acetyl-L-cysteine (NAC) significantly attenuated BC +- pollen-induced expression of ROS, NLRP3, and IL-1beta.	Acetylcysteine	46-49	interleukin 1 alpha	Homo sapiens	127-135
32779379-9	2021	NLRP3 and Caspase-1 inhibitors (MCC950 and YVAD) significantly inhibited IL-1beta expression and NLRP3 activation, but not NLRP3 expression following exposure to BC +- pollen.	YVAD	43-47	interleukin 1 alpha	Homo sapiens	73-81
32779379-10	2021	CONCLUSION: These findings suggest that exposure to BC and pollen can exaggerate oxidative stress and significantly increase the expression of IL-1beta in hNECs, and that this may involve a pathway integrating ROS-NLRP3-Caspase-1-IL-1beta signaling.	Reactive Oxygen Species	210-213	interleukin 1 alpha	Homo sapiens	143-151
32779379-10	2021	CONCLUSION: These findings suggest that exposure to BC and pollen can exaggerate oxidative stress and significantly increase the expression of IL-1beta in hNECs, and that this may involve a pathway integrating ROS-NLRP3-Caspase-1-IL-1beta signaling.	Reactive Oxygen Species	210-213	interleukin 1 alpha	Homo sapiens	230-238
33125572-3	2021	We also demonstrated that oridonin abrogated inflammation through inhibiting the phosphorylation of NF-kappaBp65 as well as its downstream gene (iNOS, COX-2, IL-1beta, and IL-6) level.	oridonin	26-34	interleukin 1 alpha	Homo sapiens	158-166
33517222-9	2021	In addition, empagliflozin treatment and downregulation of SGLT-2 expression reduced the levels of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), TGF-beta1, alpha-smooth muscle actin, collagen I, and p-Smad3 accumulation in human peritoneal mesothelial cells.	empagliflozin	13-26	interleukin 1 alpha	Homo sapiens	134-142
33998900-7	2021	Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone.	Cannabidiol	211-214	interleukin 1 alpha	Homo sapiens	38-60
33529913-0	2021	Contribution of the NLRP3/IL-1beta axis to impaired vasodilation in sepsis through facilitation of eNOS proteolysis and the protective role of melatonin.	Melatonin	143-152	interleukin 1 alpha	Homo sapiens	26-34
33998900-7	2021	Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone.	cannabigerol	216-219	interleukin 1 alpha	Homo sapiens	38-60
33529913-8	2021	In vitro, IL-1beta stimulation downregulated eNOS expression levels in human aortic endothelial cells (HAECs) in a concentration- and time-dependent manner, while pretreatment with 1 microM of the proteasome inhibitor MG132 reversed this effect.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	218-223	interleukin 1 alpha	Homo sapiens	10-18
33529913-10	2021	Notably, treatment with 30 mg/kg melatonin downregulated NLRP3 expression levels and decreased IL-1beta secretion, subsequently increasing the expression of eNOS and improving endothelium-dependent vascular relaxation.	Melatonin	33-42	interleukin 1 alpha	Homo sapiens	95-103
33529913-11	2021	In conclusion, the findings of the present study indicated that the NLRP3/IL-1beta axis may impair vasodilation by promoting the proteolysis of eNOS and melatonin may protect against sepsis-induced endothelial relaxation dysfunction by inhibiting the NLRP3/IL-1beta axis, suggesting its pharmacological potential in sepsis.	Melatonin	153-162	interleukin 1 alpha	Homo sapiens	74-82
33529913-11	2021	In conclusion, the findings of the present study indicated that the NLRP3/IL-1beta axis may impair vasodilation by promoting the proteolysis of eNOS and melatonin may protect against sepsis-induced endothelial relaxation dysfunction by inhibiting the NLRP3/IL-1beta axis, suggesting its pharmacological potential in sepsis.	Melatonin	153-162	interleukin 1 alpha	Homo sapiens	257-265
33856415-10	2021	IL-1beta and IFN-gamma levels were positively correlated with CDR (r = 0.309, P = 0.039 and r = 0.452, P = 0.006, respectively) and IOP (r = 0.292, P = 0.047 and r = 0.368, P = 0.023, respectively).	cdr	62-65	interleukin 1 alpha	Homo sapiens	0-8
33856415-13	2021	These results show, for the first time in humans, concordance with documented elevations of TNF-alpha and IL-1beta in the murine KPro model.	kpro	129-133	interleukin 1 alpha	Homo sapiens	106-114
33639176-7	2021	Baricitinib did modulate other soluble factors besides IFN-gamma, significantly decreasing the spike-specific-response mediated by IL-17, IL-1beta, IL-6, TNF-alpha, IL-4, IL-13, IL-1ra, IL-10, GM-CSF, FGF, IP-10, MCP-1, MIP-1beta (p <= 0.0156).	baricitinib	0-11	interleukin 1 alpha	Homo sapiens	138-146
33501684-8	2021	Tomentosin further inhibited the inflammatory transcription factors such as nuclear factor kappaB (NF-kappaB), tumor necrosis factor alpha, interleukin 1beta (IL-1beta), and IL-6.	tomentosin	0-10	interleukin 1 alpha	Homo sapiens	159-167
33524770-7	2021	We demonstrate that the A1 receptor is required for adenosine-stimulated IL-10 and IL-1beta secretion indicating an important role of this receptor during resolution of inflammation and tissue repair in these cells.	Adenosine	52-61	interleukin 1 alpha	Homo sapiens	83-91
33559519-7	2021	Terminal deoxynucleotidyl transferase dUTP nick-end labeling staining of liver tissue from hIL-1alpha cTg mice indicated increased apoptosis of cells in the tumor.	deoxyuridine triphosphate	38-42	interleukin 1 alpha	Homo sapiens	91-101
33559519-9	2021	In addition, cytotoxicity assay showed that CD8+ T-cell counts from tumor-bearing hIL-1alpha cTg mice correlated with cytotoxicity against EL4.	ctg	93-96	interleukin 1 alpha	Homo sapiens	82-92
33383282-10	2021	Similarly, in vitro, DEX pretreatment protected against OGD/R-induced Caco-2 cell damage and inhibited TLR4/MyD88/NF-kappaB signaling, as evidenced by increased cell viability, decreased LDH activity, reduced TNF-alpha and IL-1beta levels, as well as downregulated TLR4, MyD88, and NF-kappaB protein levels.	Dexmedetomidine	21-24	interleukin 1 alpha	Homo sapiens	223-231
33492610-7	2021	Priming the activation of the NLRP3 inflammasome, mtDAMPs promote secretion of proinflammatory cytokines, including interleukin-1beta (IL-1beta), implicated in atherosclerotic lesions through vascular smooth muscle and fibroblast proliferation, arterial wall thickening, and plaque formation.	mtdamps	50-57	interleukin 1 alpha	Homo sapiens	135-143
33492610-8	2021	In this article we critically reviewed and discussed the central role of the NLRP3 inflammasome in mtDAMP-induced sterile inflammation in atherosclerosis with specific components including caspase-1, pregnane X receptor (PXR), adenosine monophosphate activated protein kinase (AMPK), protein phosphatase 2A (PP2A), thioredoxin-interacting protein (TXNIP), and downstream cytokines including IL-1beta and IL-18 as potential mediators of atherosclerosis.	mtdamp	99-105	interleukin 1 alpha	Homo sapiens	391-399
33569904-4	2021	Conversely, we have shown that the activation of general control nonderepressible 2 (GCN2)-dependent amino acid starvation sensing pathway suppresses intestinal inflammation by inhibiting the production of reactive oxygen species (ROS) and interleukin-1 beta (IL-1beta).	Reactive Oxygen Species	206-229	interleukin 1 alpha	Homo sapiens	260-268
33387302-8	2021	Treatment of cortical astrocytes with conditioned medium (CM) from ethanol exposed ECs, upregulated astrocyte"s expression of GFAP, Cx43, and Lipocalin-2 genes, as well as the pro-inflammatory genes, IL-1beta, IL-6, and TNF-alpha, which was accompanied by NF-kappa B protein nuclear accumulation.	Ethanol	67-74	interleukin 1 alpha	Homo sapiens	200-208
33569904-4	2021	Conversely, we have shown that the activation of general control nonderepressible 2 (GCN2)-dependent amino acid starvation sensing pathway suppresses intestinal inflammation by inhibiting the production of reactive oxygen species (ROS) and interleukin-1 beta (IL-1beta).	Reactive Oxygen Species	231-234	interleukin 1 alpha	Homo sapiens	260-268
33639350-8	2021	Moreover, pretreatment with baicalein and chlorogenic acid significantly inhibited NF-kappaB activation, and this inhibited the subsequent production of the proinflammatory cytokines TNF-alpha and IL-1beta in the context of IBDV infection.	baicalein	28-37	interleukin 1 alpha	Homo sapiens	197-205
33639350-8	2021	Moreover, pretreatment with baicalein and chlorogenic acid significantly inhibited NF-kappaB activation, and this inhibited the subsequent production of the proinflammatory cytokines TNF-alpha and IL-1beta in the context of IBDV infection.	Chlorogenic Acid	42-58	interleukin 1 alpha	Homo sapiens	197-205
33869924-0	2021	Feprazone Mitigates IL-1beta-Induced Cellular Senescence in Chondrocytes.	Feprazone	0-9	interleukin 1 alpha	Homo sapiens	20-28
33932124-6	2021	It was expressed as an increase in IL-1beta concentration in culture supernatant after 24 h of higher talc dose stimulation compared to 6 h of stimulation (17.14 pg/ml [11.96-33.32 pg/ml] vs. 1.84 pg/ml [1.81-1.90 pg/ml], p = 0.02).	Talc	102-106	interleukin 1 alpha	Homo sapiens	35-43
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	62-70
33452572-2	2021	OBJECTIVES: In the research, we assessed the effects of UA on Nthy-ori 3-1 cells stimulated by IL-1beta and attempted to elucidate the mechanisms underlying the effects.	ursolic acid	56-58	interleukin 1 alpha	Homo sapiens	95-103
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	interleukin 1 alpha	Homo sapiens	65-73
33869924-3	2021	This study aims to investigate whether Feprazone has a protective effect against IL-1beta-induced cellular senescence in human chondrocytes.	Feprazone	39-48	interleukin 1 alpha	Homo sapiens	81-89
33869924-8	2021	We found that treatment with Feprazone ameliorated IL-1beta-induced increase in cellular senescence.	Feprazone	29-38	interleukin 1 alpha	Homo sapiens	51-59
33869924-14	2021	Importantly, silencing of Nrf2 abolished the protective effects of Feprazone against IL-1beta-induced NF-kappaB activation and cellular senescence.	Feprazone	67-76	interleukin 1 alpha	Homo sapiens	85-93
33782999-6	2021	Furthermore, the expression of inflammatory factors IL-1beta and IL-6 were increased and NF-kappaB signaling pathway was activated in PAHs mixture-treated cells.	pahs mixture	134-146	interleukin 1 alpha	Homo sapiens	52-60
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	interleukin 1 alpha	Homo sapiens	129-137
33855019-8	2021	When additionally stimulating macrophages with the ionophore nigericin, we observed an enhanced formation of the NLRP3 inflammasome, increased levels of cell death, and higher secreted protein levels of IL-1beta and IL-6 on compliant substrates.	Nigericin	61-70	interleukin 1 alpha	Homo sapiens	203-211
33677475-7	2021	Moreover, interleukin-1beta (IL-1beta) showed a potential to activate the chloride current of normal chondrocytes.	Chlorides	74-82	interleukin 1 alpha	Homo sapiens	29-37
33927068-16	2021	The mRNA and protein expressions of IL-6, IL-1beta, and TNF-alpha in the LPS+PDTC (10 mumol/L) group were lower than those in the LPS group (all P<0.05).	prolinedithiocarbamate	77-81	interleukin 1 alpha	Homo sapiens	42-50
33677475-8	2021	These results indicate that IL-1beta-induced chloride channel opening in chondrocytes may be closely related to the occurrence of OA.	Chlorides	45-53	interleukin 1 alpha	Homo sapiens	28-36
33782320-8	2021	Inflammatory cytokines such as IL-1alpha, IL-8, and tumor necrosis factor-alpha were suppressed by selenium in cultured orbital fibroblasts of patients with GO.	Selenium	99-107	interleukin 1 alpha	Homo sapiens	31-40
33760324-5	2021	In addition, miR-512-3p enriched by MSCs- derived exosomes markedly inhibited ox-LDL-mediated EC damage, namely, accelerated EC proliferation, inhibited Caspase-3 activation and cell apoptosis, inhibited the levels of inflammatory cytokines (tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6) and oxidative factor MDA, and increased the contents of SOD and GSH-PX.	mir-512-3p	13-23	interleukin 1 alpha	Homo sapiens	271-293
33791043-8	2021	Acute and prolonged exposure to EtOH significantly reduced dose-independent IL-1beta-induced IL-6 and TNF-alpha release, as well as adhesion capacity to pretreated HepG2 cells.	Ethanol	32-36	interleukin 1 alpha	Homo sapiens	76-84
33749948-7	2021	However, contrary to expectations, kitchen area BC and NO2 concentrations were negatively associated with IL-1beta, a pro-inflammatory marker.	Nitrogen Dioxide	55-58	interleukin 1 alpha	Homo sapiens	106-114
33524139-7	2021	Following DAAs therapy, the levels of ROS, IL-1beta, IL-6, IL-8 and TNF-alpha were significantly decreased in the three HCV groups.	daas	10-14	interleukin 1 alpha	Homo sapiens	43-51
33561652-5	2021	Two unrelated IkappaKbeta inhibitors, AFN700 and TPCA-1, when applied after priming, fully blocked IL-1beta secretion triggered by nigericin in THP-1 cells.	Nigericin	131-140	interleukin 1 alpha	Homo sapiens	99-107
33739224-8	2022	Logistic regression analysis identified the CC+CT genotype as an independent risk factor for the development of diabetes in patients with normal glucose metabolism (OR = 2.457, 95% CI: 1.238-4.877).Conclusions: The IL-1beta gene rs16944 C/T polymorphism may cause genetic susceptibility to T2DM in the Luzhou population.	Glucose	145-152	interleukin 1 alpha	Homo sapiens	215-223
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	Glucose	14-21	interleukin 1 alpha	Homo sapiens	35-43
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	interleukin 1 alpha	Homo sapiens	35-43
33729569-12	2021	CONCLUSION: Taiwanese green propolis could elicit protective effects against IL-1beta-driven inflammation in high glucose-exposed HGFs through TLR2/TLR4 combined ROS/NF-kappaB/NLRP3 inflammasome pathway.	Glucose	114-121	interleukin 1 alpha	Homo sapiens	77-85
33724512-4	2021	Administration of TTP448 in an AD cell model reduced the expression of pro-inflammatory cytokines [interleukin (IL)-1beta, IL-6, and TNF-alpha], reversed the inhibitory role of Abeta on cell proliferation and viability, and decreased Abeta-triggered cell apoptosis and reactive oxygen species (ROS) production.	Azeliragon	18-24	interleukin 1 alpha	Homo sapiens	99-121
33758527-6	2021	UHPLC profiled Coronil also modulated S-protein mediated production of pro-inflammatory cytokines in A549 cells, like interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), as evaluated through RT-qPCR and ELISA.	coronil	15-22	interleukin 1 alpha	Homo sapiens	159-167
33758527-8	2021	Treatment with Coronil significantly reduced the increased levels of IL-6, IL-1beta, and TNF-alpha in A549 cells incubated with different S-protein variants in a dose-dependent manner.	coronil	15-22	interleukin 1 alpha	Homo sapiens	75-83
33712044-6	2021	She was refractory to the combination of methotrexate and steroids to anti-interleukin (IL)-1, then anti-IL-6, tumor necrosis factor alpha inhibitors, and thalidomide.	Steroids	58-66	interleukin 1 alpha	Homo sapiens	75-93
33567990-7	2022	Medroxyprogesterone acetate (MPA)/progesterone (P4) and IL-1beta/IL-8 treatment resulted in altered TFV-DP levels in VK2 and PM1 cells.	Dipyridamole	104-106	interleukin 1 alpha	Homo sapiens	56-64
33567990-8	2022	MPA and P4 at concentrations above 0.1 microM, as well as IL-1beta and IL-8 at concentrations above 10 ng/mL significantly decreased HIV-1BaL inhibition in PM1 cells when 1 microM TFV was added.	Tenofovir	180-183	interleukin 1 alpha	Homo sapiens	58-66
33751650-12	2022	MiR-142-5p was a direct target of circSEC24A, and its upregulation ameliorated IL-1beta-induced injury and abated the effect of oe-circSEC24A in IL-1beta-induced chondrocytes.	mir-142-5p	0-10	interleukin 1 alpha	Homo sapiens	79-87
33751650-12	2022	MiR-142-5p was a direct target of circSEC24A, and its upregulation ameliorated IL-1beta-induced injury and abated the effect of oe-circSEC24A in IL-1beta-induced chondrocytes.	mir-142-5p	0-10	interleukin 1 alpha	Homo sapiens	145-153
33751650-13	2022	Additionally, SOX5 was a downstream target of miR-142-5p, and its overexpression had a similar role with oe-circSEC24A and reversed the impact of miR-142-5p in IL-1beta-induced chondrocytes.	mir-142-5p	46-56	interleukin 1 alpha	Homo sapiens	160-168
33751650-13	2022	Additionally, SOX5 was a downstream target of miR-142-5p, and its overexpression had a similar role with oe-circSEC24A and reversed the impact of miR-142-5p in IL-1beta-induced chondrocytes.	mir-142-5p	146-156	interleukin 1 alpha	Homo sapiens	160-168
33450198-5	2021	In addition, the CTSC-PR3-IL-1beta axis induces neutrophil reactive oxygen species production and formation of NETs, which degrade thrombospondin-1 and support metastatic growth of cancer cells in the lungs.	Reactive Oxygen Species	59-82	interleukin 1 alpha	Homo sapiens	26-34
33747105-13	2021	It was found that GLGZG could inhibit OGD/R-induced cell apoptosis, increase neuronal cell viability, decrease the production of IL-18 and IL-1beta, and downregulate the expression levels of pyroptosis markers (NLRP3, ASC, and caspase-1).	glgzg	18-23	interleukin 1 alpha	Homo sapiens	139-147
33655586-9	2021	After high glucose induction, the expression of TNF-alpha, IL-1beta, and IL-6 was increased and the expression of MCP-1, NLPR3, and ASC proteins was also increased (p < .001).	Glucose	11-18	interleukin 1 alpha	Homo sapiens	59-67
33791043-12	2021	Acute exposure to LoD EtOH significantly diminished the IL-1beta-induced STAT3 activation, whereas an acute exposure of cells to either HiD EtOH or in a prolonged setting showed no effects on STAT3 activation.	Ethanol	22-26	interleukin 1 alpha	Homo sapiens	56-64
33868142-9	2021	However, the expression levels of malondialdehyde and inflammatory factors (IL-1beta, TNF-alpha, IL-6, and IL-10) were remarkably decreased after the intervention of the WF.	Malondialdehyde	34-49	interleukin 1 alpha	Homo sapiens	76-84
33746753-5	2021	The modulation of glycine-mediated inhibitory activity via IL-1beta may play a critical role in the perception of different levels of pain.	Glycine	18-25	interleukin 1 alpha	Homo sapiens	59-67
33746753-11	2021	These data indicate that IL-1beta modulates GlyR activity by establishing hydrogen bonds with at least one key amino acid residue located in the back of the loop C at the ECD domain of the betaGlyR subunit.	Hydrogen	74-82	interleukin 1 alpha	Homo sapiens	25-33
33663609-8	2021	RESULTS: Glycosaminoglycan content and the expression levels of chondrogenic genes were decreased in the WJ-MSCs from IUGR, and the expression levels of chondrogenic genes were further reduced after IL-1beta treatment, while the expression levels of catabolic factors were increased.	Glycosaminoglycans	9-26	interleukin 1 alpha	Homo sapiens	199-207
33746978-6	2021	In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc.	Uric Acid	76-79	interleukin 1 alpha	Homo sapiens	109-117
33045823-11	2021	The results of statistical analysis showed that vitamin K1 and K2 levels were correlated with TNF-alpha, IL-1beta and IL-6 levels.	Vitamin K 1	48-58	interleukin 1 alpha	Homo sapiens	105-113
33977074-3	2021	Here, aiming to regulate the cartilage inflammation and degeneration related abnormal IL-1beta mRNA expression in osteoarthritis (OA), the interference oligonucleotides is integrated with the Au nanorods to fabricate the spherical nucleic acids (SNAs), to promote the stability and cell internalization efficiency.	Oligonucleotides	152-168	interleukin 1 alpha	Homo sapiens	86-94
33977074-3	2021	Here, aiming to regulate the cartilage inflammation and degeneration related abnormal IL-1beta mRNA expression in osteoarthritis (OA), the interference oligonucleotides is integrated with the Au nanorods to fabricate the spherical nucleic acids (SNAs), to promote the stability and cell internalization efficiency.	Gold	192-194	interleukin 1 alpha	Homo sapiens	86-94
32746708-7	2021	GO and MGO increased production of pro-inflammatory such as interleukin (IL)-1beta and IL-6) and MUC5AC/5B.	Glyoxal	0-2	interleukin 1 alpha	Homo sapiens	60-82
32746708-7	2021	GO and MGO increased production of pro-inflammatory such as interleukin (IL)-1beta and IL-6) and MUC5AC/5B.	Pyruvaldehyde	7-10	interleukin 1 alpha	Homo sapiens	60-82
32746708-9	2021	Whether ERK1/2, p38 MAPK, and NF-kappaB signaling pathway were involved in GO and MGO-induced production of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B, we used specific inhibitors and siRNA transfection.	Pyruvaldehyde	82-85	interleukin 1 alpha	Homo sapiens	136-144
32746708-10	2021	These significantly repressed GO- and MGO-induced expression of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B.	Glyoxal	30-32	interleukin 1 alpha	Homo sapiens	92-100
32746708-10	2021	These significantly repressed GO- and MGO-induced expression of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B.	Pyruvaldehyde	38-41	interleukin 1 alpha	Homo sapiens	92-100
33472098-8	2021	EGCG inhibited expression of IL-1beta, IL-6, and TNF-alpha.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	29-37
33755250-5	2021	After being synthesized, IL-1 induces numerous inflammatory mediators including itself, other pro-inflammatory cytokines/chemokines, and arachidonic acid products, which contribute to the pathogenesis of immune diseases.	Arachidonic Acid	137-153	interleukin 1 alpha	Homo sapiens	25-29
33245515-6	2021	ELISA analysis found that GA dose-dependently reduced the production of pro-inflammatory mediators TNF-alpha and IL-1beta.	Gallium	26-28	interleukin 1 alpha	Homo sapiens	113-121
33205391-12	2021	Importantly, AS101 significantly reduced mRNA levels of pro-inflammatory mediators such as IL-6 (p<0.05) and IL-1beta (p<0.01) in activated primary human fibroblasts.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	13-18	interleukin 1 alpha	Homo sapiens	109-117
33571641-7	2021	Knock-down of TNXIP rescued the endothelial cells from CIH-induced apoptosis, indicating that activation of the TXNIP/NLRP3/IL-1beta pathway mediated the CIH-induced endothelial apoptosis.	cih	55-58	interleukin 1 alpha	Homo sapiens	124-132
33433347-5	2021	Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity.	Cadmium	26-28	interleukin 1 alpha	Homo sapiens	94-102
33433347-5	2021	Simultaneously, Mo or/and Cd upregulated ASC, NLRP3, NEK7, Caspase-1, GSDMA, GSDME, IL-18 and IL-1beta mRNA levels and Caspase-1 p20, NLRP3, ASC, GSDMD protein levels, increased the percentage of pyroptotic cells, LDH, NO, IL-18 and IL-1beta releases as well as relative conductivity.	Cadmium	26-28	interleukin 1 alpha	Homo sapiens	233-241
32588217-0	2021	Unmetabolized folic acid is associated with TNF-alpha, IL-1beta and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil.	Folic Acid	14-24	interleukin 1 alpha	Homo sapiens	55-63
32588217-9	2021	CONCLUSION: UMFA concentrations were inversely associated with elevated proinflammatory markers (TNF-alpha, IL-1beta and IL-12).	umfa	12-16	interleukin 1 alpha	Homo sapiens	108-116
33571641-7	2021	Knock-down of TNXIP rescued the endothelial cells from CIH-induced apoptosis, indicating that activation of the TXNIP/NLRP3/IL-1beta pathway mediated the CIH-induced endothelial apoptosis.	cih	154-157	interleukin 1 alpha	Homo sapiens	124-132
33571641-8	2021	Administration of the mitochondria-targeted antioxidant mito-TEMPO improved mitochondrial function and suppressed upregulation of the TXNIP/NLRP3/IL-1beta pathway, thereby alleviating CIH-induced endothelial apoptosis.	cih	184-187	interleukin 1 alpha	Homo sapiens	146-154
32946147-9	2021	Remarkably, the addition of 2DG to blunt the microglial glycolytic increase also inhibited HIF-1alpha accumulation and IL-1beta production, and therefore rescued LTP in LPS-stimulated slices.	Deoxyglucose	28-31	interleukin 1 alpha	Homo sapiens	119-127
33571641-10	2021	The results imply that CIH-induced mitochondrial dysfunction mediates endothelial injury implication of TXNIP/NLRP3/IL-1beta signaling pathway.	cih	23-26	interleukin 1 alpha	Homo sapiens	116-124
33131052-5	2021	While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate.	Zoledronic Acid	6-17	interleukin 1 alpha	Homo sapiens	87-109
33131052-7	2021	Since it is generally accepted that monocytes and macrophages are primary sources of inflammatory cytokines, CD14+ cells from PBMC were exposed to zoledronate in the presence of PBMC, which resulted in induced expression of mRNAs for IL-1beta, IL-6, and IFN-gamma, but not for TNF-alpha.	Zoledronic Acid	147-158	interleukin 1 alpha	Homo sapiens	234-242
33131052-8	2021	These results indicate that CD14+ cells are responsible, at least in part, for the production of IL-1beta, IL-6, and IFN-gamma in blood exposed to zoledronate.	Zoledronic Acid	147-158	interleukin 1 alpha	Homo sapiens	97-105
33448324-4	2021	The results revealed that miR-101-3p was upregulated in the serum of patients with sepsis-induced cardiomyopathy (SIC) and positively correlated with the levels of pro-inflammatory cytokines (including IL-1beta, IL-6 and TNF-alpha).	mir-101-3p	26-36	interleukin 1 alpha	Homo sapiens	202-210
33461161-8	2021	RESULTS: As a result of oxidative stress, MiR-494-3p was increased via the p38MAPK-c-myc signaling pathway in the lung tissues and cells of patients with COPD, and the increase in miR-494-3p was accompanied by increases in senescence markers (p27, p21 and p16) and SASP proteins (IL-1beta, TNF-alpha, MMP2 and MMP9).	mir-494-3p	42-52	interleukin 1 alpha	Homo sapiens	280-288
33461161-11	2021	Inhibition of miR-494-3p in SAECs from COPD patients reduced cell cycle arrest and the expression of SASP proteins (IL-1beta, TNF-alpha, MMP2 and MMP9).	mir-494-3p	14-24	interleukin 1 alpha	Homo sapiens	116-124
33755043-9	2021	Th-17 associated SNPs (chr1: IL-23R rs11209026, chr2: IL-1beta rs16944, and chr12: IL-22 rs1179251) were also associated with SICs.	Thorium	0-2	interleukin 1 alpha	Homo sapiens	54-62
33687909-6	2021	The production of IL-1beta was highly enhanced when the macrophages were treated with LPS and ClyA together.	clya	94-98	interleukin 1 alpha	Homo sapiens	18-26
33201565-12	2021	Cell experiments showed that overexpression of miR-221-5p significantly inhibited the expression of inflammatory factors tumor necrosis factor-alpha, IL-8, and IL-1beta, while down-regulation of miR-221-5p was the opposite.	-221-5p	50-57	interleukin 1 alpha	Homo sapiens	160-168
33091489-11	2021	Also, the expression of IL-5 in mast cells enhanced by stimulation with TSLP plus IL-1beta was significantly downregulated by baicalin treatment.	baicalin	126-134	interleukin 1 alpha	Homo sapiens	82-90
33484883-9	2021	Propolis suppressed an increase in IL-1beta and TNF-alpha upon stimulation with H2O2 in young and SA-beta-gal-expressing senescent human gingival fibroblasts (HGFs) cultures.	Hydrogen Peroxide	80-84	interleukin 1 alpha	Homo sapiens	35-43
33333144-7	2021	Only cholesterol-GGGCKAPETA (responsive to MMP-9) NPs showed <5% haemolysis, <1 pg/mL release of IL-1beta at 500 mug/mL from THP1 cells, with 70.75+-5.78% of NPs crossing the BBB at 24 h in presence of active MMP-9.	Cholesterol	5-16	interleukin 1 alpha	Homo sapiens	97-105
33333144-7	2021	Only cholesterol-GGGCKAPETA (responsive to MMP-9) NPs showed <5% haemolysis, <1 pg/mL release of IL-1beta at 500 mug/mL from THP1 cells, with 70.75+-5.78% of NPs crossing the BBB at 24 h in presence of active MMP-9.	gggckapeta	17-27	interleukin 1 alpha	Homo sapiens	97-105
33495807-11	2021	The inhibition of SOCS3 significantly activated JAK1/STAT3 signaling, as well as enhancing the levels of TNF-alpha, IL-6 and IL-1beta, and promoting apoptosis, which was reversed by the JAK1 inhibitor Tofacitinib.	tofacitinib	201-212	interleukin 1 alpha	Homo sapiens	125-133
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	interleukin 1 alpha	Homo sapiens	150-158
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	interleukin 1 alpha	Homo sapiens	150-158
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Hydrogen Peroxide	211-215	interleukin 1 alpha	Homo sapiens	150-158
33285592-4	2021	Flavones derivatives 1: -4: with a C-3"/4" methylenedioxy substituent led to a substantial increase in the production of IL-1beta and GM-CSF out of 4 pro-inflammatory cytokines relative to LPS control.	Flavones	0-8	interleukin 1 alpha	Homo sapiens	121-129
32969125-8	2021	Of relevance to severe coronavirus-19 disease (COVID-19), which is characterised by an over-exuberant innate inflammatory response, AZM also has anti-inflammatory properties including suppression of IL-1beta, IL-2, TNF and GM-CSF.	Azithromycin	132-135	interleukin 1 alpha	Homo sapiens	199-207
33609988-0	2021	Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1beta levels in patients with schizophrenia spectrum disorder and their siblings.	Kynurenine	19-29	interleukin 1 alpha	Homo sapiens	88-96
33609988-10	2021	SCZ and SIB groups had higher serum IL-1beta levels than controls (p <= 0.001).	SCZ	0-3	interleukin 1 alpha	Homo sapiens	36-44
33383234-9	2021	H2O2 supplementation elevated the expression of NLRP3 inflammasome and increased IL-1beta secretion in ITP platelets.	Hydrogen Peroxide	0-4	interleukin 1 alpha	Homo sapiens	81-89
33383234-11	2021	Pretreating ITP platelets with NLRP3 inhibitor MCC950 or caspase-1 inhibitor Z-YVAD-FMK significantly reduced the proportion of pyroptotic cells in H2O2-treated ITP platelets and suppressed IL-1beta secretion in supernatants.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	77-87	interleukin 1 alpha	Homo sapiens	190-198
33271325-6	2021	Although pazopanib increased the production of IL-1beta, inflammasomes were not activated because caspase-1 was not activated in differentiated THP-1 cells.	pazopanib	9-18	interleukin 1 alpha	Homo sapiens	47-55
33271325-8	2021	Although pazopanib did not activate inflammasomes, it did cause increased IL-1beta production, which may facilitate the induction of idiosyncratic reactions.	pazopanib	9-18	interleukin 1 alpha	Homo sapiens	74-82
33524445-2	2021	Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages.	Niclosamide	0-11	interleukin 1 alpha	Homo sapiens	90-98
33524445-2	2021	Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	13-17	interleukin 1 alpha	Homo sapiens	90-98
33524445-2	2021	Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages.	Adenosine Triphosphate	47-50	interleukin 1 alpha	Homo sapiens	90-98
33673529-7	2021	Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner.	Histamine	27-36	interleukin 1 alpha	Homo sapiens	223-245
33673529-7	2021	Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner.	Histamine	40-49	interleukin 1 alpha	Homo sapiens	223-245
33652555-6	2021	BA treatment repressed LPS-induced expression of TNF-alpha and IL-1beta.	baicalin	0-2	interleukin 1 alpha	Homo sapiens	63-71
33652665-4	2021	Subsequently, their effects with methyldopa on the expression of selected markers responsible for inflammation (TNF-alpha; IL-1beta; IL-6) and vascular effects (hypoxia-inducible factor 1alpha-HIF-1alpha; placental growth factor-PIGF; transforming growth factor beta-TGF-beta; vascular endothelial growth factor-VEGF) at the mRNA and protein levels were assessed.	Methyldopa	33-43	interleukin 1 alpha	Homo sapiens	123-131
33669093-7	2021	Our data suggested that tempol treatment is able to reduce inflammation and nitrite production in LPS-induced J774 as well as reducing the production of proinflammatory mediators including cytokines, enzymes, and metalloproteases (MMPs) in IL-1beta-stimulated CC.	tempol	24-30	interleukin 1 alpha	Homo sapiens	240-248
33668814-7	2021	In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)).	Polyphenols	13-24	interleukin 1 alpha	Homo sapiens	226-230
33626512-4	2021	Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1beta, IL-18, and gasdermin D.	Nicotine	54-62	interleukin 1 alpha	Homo sapiens	318-326
33626512-4	2021	Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1beta, IL-18, and gasdermin D.	Reactive Oxygen Species	173-176	interleukin 1 alpha	Homo sapiens	318-326
33665661-10	2021	The results showed that E2 significantly inhibited the IL-1beta-induced apoptosis of NPCs, reversed the decrease of cell viability and adhesion induced by IL-1beta, and inhibited the down-regulation of mTOR phosphorylation level induced by IL-1beta.	Estradiol	24-26	interleukin 1 alpha	Homo sapiens	55-63
33665661-10	2021	The results showed that E2 significantly inhibited the IL-1beta-induced apoptosis of NPCs, reversed the decrease of cell viability and adhesion induced by IL-1beta, and inhibited the down-regulation of mTOR phosphorylation level induced by IL-1beta.	Estradiol	24-26	interleukin 1 alpha	Homo sapiens	155-163
33665661-10	2021	The results showed that E2 significantly inhibited the IL-1beta-induced apoptosis of NPCs, reversed the decrease of cell viability and adhesion induced by IL-1beta, and inhibited the down-regulation of mTOR phosphorylation level induced by IL-1beta.	Estradiol	24-26	interleukin 1 alpha	Homo sapiens	155-163
33665661-12	2021	These results suggest that E2 may inhibit IL-1beta-induced NPCs" apoptosis through the PI3K/Akt/mTOR signaling pathway.	Estradiol	27-29	interleukin 1 alpha	Homo sapiens	42-50
33708197-5	2021	We demonstrate that the maturation and secretion of IL-1beta during SFTSV infection is mediated by the nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin-containing domain 3 (NLRP3) inflammasome.	Leucine	142-149	interleukin 1 alpha	Homo sapiens	52-60
33672354-8	2021	Celecoxib and dexamethasone-loaded nanoparticles reduced the release of different inflammatory mediators (NO, TNF-alpha, IL-1beta, IL-6, PGE2 and IL-10) by lipopolysaccharide (LPS)-stimulated RAW264.7.	Celecoxib	0-9	interleukin 1 alpha	Homo sapiens	121-129
33672354-8	2021	Celecoxib and dexamethasone-loaded nanoparticles reduced the release of different inflammatory mediators (NO, TNF-alpha, IL-1beta, IL-6, PGE2 and IL-10) by lipopolysaccharide (LPS)-stimulated RAW264.7.	Dexamethasone	14-27	interleukin 1 alpha	Homo sapiens	121-129
33841139-10	2021	The miR-145-5p inhibitor and NF-kappaBp65 transfection reversed the attenuated expressions of NF-kappaBp65, TNF-alpha, and IL-1beta.	mir-145-5p	4-14	interleukin 1 alpha	Homo sapiens	123-131
33616827-8	2021	Fisetin treatment alleviated cell injury and suppressed the inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), interleukin-16 (IL-6), and prostaglandin E2 (PGE2)) and antioxidant parameters in a dose-dependent manner.	fisetin	0-7	interleukin 1 alpha	Homo sapiens	99-103
33616827-8	2021	Fisetin treatment alleviated cell injury and suppressed the inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), interleukin-16 (IL-6), and prostaglandin E2 (PGE2)) and antioxidant parameters in a dose-dependent manner.	fisetin	0-7	interleukin 1 alpha	Homo sapiens	207-215
33616827-10	2021	Fisetin significantly (P < 0.001) suppressed the neurological parameters and inflammatory cytokines such as IL-1, TNF-alpha, iNOS, IL-1beta, COX-2, IL-6, PGE2, and oxidative markers in a dose-dependent manner.	fisetin	0-7	interleukin 1 alpha	Homo sapiens	108-112
33616827-10	2021	Fisetin significantly (P < 0.001) suppressed the neurological parameters and inflammatory cytokines such as IL-1, TNF-alpha, iNOS, IL-1beta, COX-2, IL-6, PGE2, and oxidative markers in a dose-dependent manner.	fisetin	0-7	interleukin 1 alpha	Homo sapiens	131-139
33671522-8	2021	Furthermore, LPG displayed a stronger effect than HPG on inhibiting pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) productions.	4-HYDROXYPHENYL GLYOXAL	50-53	interleukin 1 alpha	Homo sapiens	106-114
33609028-11	2021	The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 MAP kinase, and the expression of CCL-28 and IL-8 in IL-1beta-stimulated Caco-2 cells.	GW 3965	26-32	interleukin 1 alpha	Homo sapiens	208-216
33610183-11	2021	The addition of nicotinamide, a Sirt1 inhibitor, downregulated SOX9 and attenuated the therapeutic effects of SMN on IL-1beta-stimulated chondrocytes.	Niacinamide	16-28	interleukin 1 alpha	Homo sapiens	117-125
33611821-5	2021	Ethanol caused a unique immune gene signature that featured: temporal induction of pro-inflammatory TNF-alpha and IL-1beta, reduction of homeostatic microglia state gene Tmem119, progressive increases in purinergic receptor P2RY12 and the microglial inhibitory fractalkine receptor CX3CR1, an increase in the microglial presynaptic gene C1q, and a reduction in the phagocytic gene TREM2.	Ethanol	0-7	interleukin 1 alpha	Homo sapiens	114-122
33611821-6	2021	MV signaling was implicated in this response as reduction of MV secretion by imipramine blocked pro-inflammatory TNF-alpha and IL-1beta induction by ethanol, and ethanol-conditioned MVs (EtOH-MVs) reproduced the ethanol-associated immune gene signature in naive OBSC slices.	Imipramine	77-87	interleukin 1 alpha	Homo sapiens	127-135
33611821-6	2021	MV signaling was implicated in this response as reduction of MV secretion by imipramine blocked pro-inflammatory TNF-alpha and IL-1beta induction by ethanol, and ethanol-conditioned MVs (EtOH-MVs) reproduced the ethanol-associated immune gene signature in naive OBSC slices.	Ethanol	149-156	interleukin 1 alpha	Homo sapiens	127-135
33657052-9	2021	Results showed that DLT-SML significantly decreased serum TG, TC, LDL-c, IL-1beta, TNF-alpha, and TMAO levels of CSA patients.	dlt-sml	20-27	interleukin 1 alpha	Homo sapiens	73-81
33614444-8	2021	In addition, MSC-CMT treatment significantly reduced CD11b+ inflammatory cell infiltration, and inhibited the expression of pro-inflammatory cytokines (IL-1beta, TNF-alpha and IL-6).	cmt	17-20	interleukin 1 alpha	Homo sapiens	152-160
33746591-0	2021	Acid-electrolyzed functional water-induces Interleukin-1alpha release from Intracellular Storage Sites in Oral Squamous Cell Carcinoma.	Water	29-34	interleukin 1 alpha	Homo sapiens	43-61
33746591-4	2021	FW treatment significantly induced interleukin (IL)-1alpha secretion, which was confirmed by enzyme-linked immunosorbent assay.	phenylalanyltryptophan	0-2	interleukin 1 alpha	Homo sapiens	35-58
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Paroxetine	34-44	interleukin 1 alpha	Homo sapiens	391-399
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Fluoxetine	46-56	interleukin 1 alpha	Homo sapiens	391-399
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Sertraline	58-68	interleukin 1 alpha	Homo sapiens	391-399
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Citalopram	70-80	interleukin 1 alpha	Homo sapiens	391-399
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Fluvoxamine	86-97	interleukin 1 alpha	Homo sapiens	391-399
33602262-8	2021	The SNRI venlafaxine was the least toxic to astrocytes and inhibited the production of IL-6 and IL-1beta but with no impact on iNOS and NO.	Venlafaxine Hydrochloride	9-20	interleukin 1 alpha	Homo sapiens	96-104
33596128-4	2021	RESULTS: The results indicated that while palmitate enhances the expression and secretion of TNF-alpha, IL-6, and IL-1beta, and also intracellular ROS level, FA at concentrations of 25, 50, and 75 microg/mL significantly reversed these effects in HepG2 cells.	Palmitates	42-51	interleukin 1 alpha	Homo sapiens	114-122
33596205-14	2021	In sharp contrast, dexamethasone was able to control the capacity of pro-inflammatory cytokines, IL-1beta as well as TNFalpha, to stimulate mRNA levels of cPLA2alpha, COX-2 and mPGES-1.	Dexamethasone	19-32	interleukin 1 alpha	Homo sapiens	97-105
33593369-5	2021	Colchicine has many anti-inflammatory and cardiovascular protective properties, including inhibition of IL-1beta and IL-18 activity, key proinflammatory cytokines that are predictive of future adverse cardiovascular events.	Colchicine	0-10	interleukin 1 alpha	Homo sapiens	104-112
33357860-7	2021	The HA-DEX-DOX also polarized bone-marrow-derived anti-inflammatory M2 macrophages, to pro-inflammatory M1 phenotype with the upregulation of the cytokines TNF-alpha, iNOS and IL-1beta.	ha-dex-dox	4-14	interleukin 1 alpha	Homo sapiens	176-184
33659001-4	2021	In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1beta and TNF-alpha release but decreased IL-23 release, with negative correlations observed between urine SigmaDEHP and serum IL-23 levels in patients.	mono-(2-ethylhexyl)phthalate	108-112	interleukin 1 alpha	Homo sapiens	134-142
33053467-4	2021	HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)].	Silicon Dioxide	20-24	interleukin 1 alpha	Homo sapiens	200-208
33278766-9	2021	Conversely, progesterone was negatively correlated with IL-1beta and several metabolites in the kynurenine pathway, including quinolinic acid.	Progesterone	12-24	interleukin 1 alpha	Homo sapiens	56-64
33278766-9	2021	Conversely, progesterone was negatively correlated with IL-1beta and several metabolites in the kynurenine pathway, including quinolinic acid.	Quinolinic Acid	126-141	interleukin 1 alpha	Homo sapiens	56-64
33380496-9	2021	Nano-11 and cdAMP demonstrated a strong synergistic interaction, as shown in the activation of mouse, human, and porcine APC, with increased expression of costimulatory molecules and secretion of TNF and IL-1beta.	nano-11	0-7	interleukin 1 alpha	Homo sapiens	204-212
33380496-9	2021	Nano-11 and cdAMP demonstrated a strong synergistic interaction, as shown in the activation of mouse, human, and porcine APC, with increased expression of costimulatory molecules and secretion of TNF and IL-1beta.	O-cyclopentyl-S-diethylaminoethyl methylphosphonothioate	12-17	interleukin 1 alpha	Homo sapiens	204-212
33580734-9	2021	PBM reduced TNF-alpha, IL-1beta, IL-6, brain damage, neuroinflammation, and microglial activation, and it increased astroglial activity in peri-lesioned region after stroke.	pbm	0-3	interleukin 1 alpha	Homo sapiens	23-31
33673103-1	2021	This study evaluated the effect of anandamide (AEA) on interleukin (IL)-1beta synthesis and gene expression of IL-1beta, its type I (IL-1R1) and II (IL-1R2) receptors, and IL-1 receptor antagonist (IL-1RN) in the hypothalamic structures, involved in the central control of reproduction, during inflammation.	aea	47-50	interleukin 1 alpha	Homo sapiens	55-77
33673103-6	2021	AEA injection (p < 0.05) suppressed LPS-induced expression of IL-1beta protein in the hypothalamus.	aea	0-3	interleukin 1 alpha	Homo sapiens	62-70
33673103-7	2021	The gene expression of IL-1beta, IL-1RN, and IL-1R2 in the hypothalamic structures was higher (p < 0.05) in animals treated with both LPS and AEA in comparison to other experimental groups.	aea	142-145	interleukin 1 alpha	Homo sapiens	23-31
33673103-9	2021	Our study shows that AEA suppressed IL-1beta synthesis in the hypothalamus, likely affecting posttranscriptional levels of this cytokine synthesis.	aea	21-24	interleukin 1 alpha	Homo sapiens	36-44
33578781-5	2021	Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1beta, IL-6, IL-8, COX-2, and TNF-alpha) as well as NF-kappaB activation, which were all blocked by FK866.	Hydrogen Peroxide	37-41	interleukin 1 alpha	Homo sapiens	271-279
33568652-6	2021	These epoxides reduce the pro-inflammatory biomarkers IL-6, IL-1beta, TNF-alpha and nitrous oxide and raise anti-inflammatory IL-10 cytokine in activated microglial cells.	Epoxy Compounds	6-14	interleukin 1 alpha	Homo sapiens	60-68
33567596-6	2021	Our results showed that (i) caffeic acid targets COX-2 and its product PGE2 as well as the biosynthesis of IL-8 in the IL-1beta-treated cells and (ii) inhibits AGE formation, which could be related to (iii) the high chelating activity exerted.	caffeic acid	28-40	interleukin 1 alpha	Homo sapiens	119-127
33562298-7	2021	However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1beta, as shown by down regulation of Il-1beta, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2.	ursodoxicoltaurine	27-32	interleukin 1 alpha	Homo sapiens	77-85
33562298-7	2021	However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1beta, as shown by down regulation of Il-1beta, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2.	ursodoxicoltaurine	27-32	interleukin 1 alpha	Homo sapiens	118-126
33561944-11	2021	The anti-inflammatory effect of cHA-Cr-L was achieved through a significant reduction of IL-1beta and TNFalpha (p < 0.001).	cha-cr-l	32-40	interleukin 1 alpha	Homo sapiens	89-97
33547278-2	2021	Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1beta (IL-1beta) in murine macrophages.	Uric Acid	36-38	interleukin 1 alpha	Homo sapiens	110-118
33507306-5	2021	We found that tunicamycin-induced ER stress inhibited NF-kappaB activation and pro-inflammatory cytokine (IL-6 and COX2) production in TNF-alpha- or IL-1beta-treated normal endometrial stromal cells (NECSs).	Tunicamycin	14-25	interleukin 1 alpha	Homo sapiens	149-157
33507306-6	2021	Tunicamycin increased the expression of A20 and C/EBPbeta, which are negative regulators of NF-kappaB, and this increase inhibited NF-kappaB activity in NESCs incubated with TNF-alpha- or IL-1beta.	Tunicamycin	0-11	interleukin 1 alpha	Homo sapiens	188-196
33546705-10	2021	Furthermore, E. coli KUB-36 metabolites and individual SCFA could affect inflammatory responses in lipopolysaccharide-induced THP-1 macrophage cells since they suppressed inflammatory cytokines IL-1beta, IL-6, IL-8 and TNF-alpha well as compared to the control, whilst inducing anti-inflammatory cytokine IL-10 expression.	Fatty Acids, Volatile	55-59	interleukin 1 alpha	Homo sapiens	194-202
33557291-9	2021	Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point.	Hydrocortisone	34-42	interleukin 1 alpha	Homo sapiens	74-96
33613529-11	2020	Results: LPS/Nigericin increased NRLP3 protein expression as well as IL-1beta and IL-18 secretion in PC3 and U138MG cells compared to A549, MCF7, SH-SY5Y cells, and fibroblasts.	Nigericin	13-22	interleukin 1 alpha	Homo sapiens	69-77
33613529-18	2020	Discussion: Our data suggest that NLRP3 activation using Nigericin could be a novel therapeutic approach to control the growth of tumors producing a low level of IL-1beta and IL-18.	Nigericin	57-66	interleukin 1 alpha	Homo sapiens	162-170
33546151-12	2021	In addition, AgNP-induced autophagy reduced the levels of IL-1beta and NLRP3 inflammasome activation.	agnp	13-17	interleukin 1 alpha	Homo sapiens	58-66
33549578-7	2021	Quantitative real-time PCR (qRT-PCR) analysis revealed a remarkable decrease in IL-6, TNF-alpha, cyclooxygenase-2 (COX-2) and interleukin-1beta (IL-1beta) mRNA levels in the coelonin and militarine-pretreated groups.	coelonin	174-182	interleukin 1 alpha	Homo sapiens	145-153
33549578-7	2021	Quantitative real-time PCR (qRT-PCR) analysis revealed a remarkable decrease in IL-6, TNF-alpha, cyclooxygenase-2 (COX-2) and interleukin-1beta (IL-1beta) mRNA levels in the coelonin and militarine-pretreated groups.	militarine	187-197	interleukin 1 alpha	Homo sapiens	145-153
33605079-11	2021	Furthermore, LPZ deteriorated cisplatin-induced inflammation, as revealed by the increased mRNA expression of pro-inflammatory factors including, NLRP3, IL-1beta, TNF-alpha and caspase 1, as well as neutrophil infiltration.	Lansoprazole	13-16	interleukin 1 alpha	Homo sapiens	153-161
33854710-12	2021	ITIID&CP had the highest IL-6 and IL-1beta/IL-10 ratios.	itiid&cp	0-8	interleukin 1 alpha	Homo sapiens	34-42
33315168-10	2021	Colchicine and interleukin-1 inhibitors were used in the management of the steroid-resistant adult syndrome.	Steroids	75-82	interleukin 1 alpha	Homo sapiens	15-28
33455051-5	2021	In addition, pretreating cells with lycorine hydrochloride significantly inhibited the expression of CXCL1 and IL1alpha, two factors of the senescence-associated secreted phenotype (SASP) in SIPS cells.	Lycorine hydrochloride	36-58	interleukin 1 alpha	Homo sapiens	111-119
33159583-5	2021	PM10-induced NICD signaling causes increased expression of interleukin-1 beta (IL-1beta) and enhances characteristics of cellular senescence, which leads to increased endothelial permeability in HBMECs.	pm10	0-4	interleukin 1 alpha	Homo sapiens	79-87
33537886-4	2021	G-Rg2 and -Rh1 treatment significantly inhibited activation of STAT3 and TAK1, and inflammatory factors including iNOS, TNF-alpha, and IL-1beta in peritoneal macrophages.	ginsenoside Rg2	0-5	interleukin 1 alpha	Homo sapiens	135-143
33537886-4	2021	G-Rg2 and -Rh1 treatment significantly inhibited activation of STAT3 and TAK1, and inflammatory factors including iNOS, TNF-alpha, and IL-1beta in peritoneal macrophages.	2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	10-14	interleukin 1 alpha	Homo sapiens	135-143
33044583-11	2021	However, both the 1.8 cineole treatment and alpha-pinene treatments significantly decreased TNF-alpha, IL-1beta, IL-6, and eNOS mRNA expression induced by LPS.	Eucalyptol	22-29	interleukin 1 alpha	Homo sapiens	103-111
33044583-11	2021	However, both the 1.8 cineole treatment and alpha-pinene treatments significantly decreased TNF-alpha, IL-1beta, IL-6, and eNOS mRNA expression induced by LPS.	alpha-pinene	44-56	interleukin 1 alpha	Homo sapiens	103-111
33341671-12	2021	Lip-Ful was also found to induce secretion of pro-inflammatory TNF-alpha, IFN-gamma and IL-1beta cytokines.	lip-ful	0-7	interleukin 1 alpha	Homo sapiens	88-96
32333793-10	2021	Compared to the placebo group, for a 10-mug/m3 increase in PM2.5 , the increments of interleukin-1alpha and carbonyl protein in the fish-oil group were 41.55% smaller (95% confidence interval: 4.61%, 78.48%) at lag 0-48 h and 22.01% smaller (95% confidence interval: 11.25%, 32.77%) at lag 0-24 h, respectively.	Oils	137-140	interleukin 1 alpha	Homo sapiens	85-103
33295155-5	2021	RESULTS: We propose a speculative hypothesis concerning the complex interplay of these signaling molecules during chronic stress, highlighting the role of IL-1beta as main biomarker of this effects, indeed, during chronic stress its increment transforms this inflammatory signal into a nervous signal (NE), in turn, this uses the ES (melatonin and cortisol) to counterbalance again IL-1beta.	Melatonin	334-343	interleukin 1 alpha	Homo sapiens	155-163
33295155-5	2021	RESULTS: We propose a speculative hypothesis concerning the complex interplay of these signaling molecules during chronic stress, highlighting the role of IL-1beta as main biomarker of this effects, indeed, during chronic stress its increment transforms this inflammatory signal into a nervous signal (NE), in turn, this uses the ES (melatonin and cortisol) to counterbalance again IL-1beta.	Hydrocortisone	348-356	interleukin 1 alpha	Homo sapiens	155-163
33295155-8	2021	IL-1beta might, through melatonin and vice versa, determine sleep disorders too.	Melatonin	24-33	interleukin 1 alpha	Homo sapiens	0-8
33542198-4	2021	After cisplatin treatment, GSDME-mediated pyroptosis was induced as shown by the characteristic pyroptotic morphology in TECs, upregulated GSDME-N expression and enhanced release of IL-1beta and LDH, and decreased cell viability.	Cisplatin	6-15	interleukin 1 alpha	Homo sapiens	182-190
33542198-4	2021	After cisplatin treatment, GSDME-mediated pyroptosis was induced as shown by the characteristic pyroptotic morphology in TECs, upregulated GSDME-N expression and enhanced release of IL-1beta and LDH, and decreased cell viability.	gsdme	27-32	interleukin 1 alpha	Homo sapiens	182-190
33022353-6	2021	Overexpression of duIKKalpha dramatically increased NF-kappaB activity and induced the expression of duck cytokines IFN-beta, IL-1beta, IL-6, IL-8 and RANTES in DEFs.	duikkalpha	18-28	interleukin 1 alpha	Homo sapiens	126-134
33171231-0	2021	Inhibition of NLRP3-inflammasome mediated IL-1beta release by phenylpropanoic acid derivatives: in-silico and in-vitro approach.	3-phenylpropionic acid	62-82	interleukin 1 alpha	Homo sapiens	42-50
33171231-3	2021	The study was carried out to test the ability of phenylpropanoic acid derivatives to inhibit the NLRP3 inflammasome pathway and IL-1beta release.	3-phenylpropionic acid	49-69	interleukin 1 alpha	Homo sapiens	128-136
33629290-8	2021	RESULTS: HIF-1alpha and Runx2 were increased, and glucose uptake and ATP generation were decreased in the degenerative CHs from both OA and IL-1beta conditions.	Glucose	50-57	interleukin 1 alpha	Homo sapiens	140-148
33629290-8	2021	RESULTS: HIF-1alpha and Runx2 were increased, and glucose uptake and ATP generation were decreased in the degenerative CHs from both OA and IL-1beta conditions.	Adenosine Triphosphate	69-72	interleukin 1 alpha	Homo sapiens	140-148
32949301-5	2021	Cells were basally stimulated with agonists Pam2CSK4 (Pam; TLR2), polyinosinic/polycytidylic acid (Poly I:C; TLR3), and lipopolysaccharide (LPS; TLR4) for 24 h. Supernatants were evaluated with ELISA for cytokines TNFalpha, IL-6, and IL-1beta.	Carbon	0-1	interleukin 1 alpha	Homo sapiens	234-242
32803665-5	2021	PGAL decreased IL-6, TNF-alpha, and IL-1beta production in human monocytes exposed to PMA without affecting cell viability.	L-Lysine L-glutamate	0-4	interleukin 1 alpha	Homo sapiens	36-44
32803665-5	2021	PGAL decreased IL-6, TNF-alpha, and IL-1beta production in human monocytes exposed to PMA without affecting cell viability.	Tetradecanoylphorbol Acetate	86-89	interleukin 1 alpha	Homo sapiens	36-44
33309621-2	2021	Reactive oxygen species (ROS) has been shown to activate pyroptosis and promote the production of interleukin (IL)-1beta and IL-18, leading to fibrosis development.	Reactive Oxygen Species	0-23	interleukin 1 alpha	Homo sapiens	98-120
33309621-2	2021	Reactive oxygen species (ROS) has been shown to activate pyroptosis and promote the production of interleukin (IL)-1beta and IL-18, leading to fibrosis development.	Reactive Oxygen Species	25-28	interleukin 1 alpha	Homo sapiens	98-120
33326919-6	2021	In this study, we indicated that DPF-6 inhibited inflammation and the expression of TNF-alpha, IL-6 and IL-1beta in liver tissues and LPS-mediated L-02 cells, concomitant with the upregulated expression of ZEB2.	dpf-6	33-38	interleukin 1 alpha	Homo sapiens	104-112
33360372-12	2021	MiR-183-5p restoration also enhanced IL-1beta-blocked cell proliferation, and relieved IL-1beta-induced cell apoptosis and ECM degradation, while GREM1 (a target of miR-183-5p) overexpression abolished the effects of miR-183-5p restoration.	mir-183-5p	0-10	interleukin 1 alpha	Homo sapiens	37-45
33360372-12	2021	MiR-183-5p restoration also enhanced IL-1beta-blocked cell proliferation, and relieved IL-1beta-induced cell apoptosis and ECM degradation, while GREM1 (a target of miR-183-5p) overexpression abolished the effects of miR-183-5p restoration.	mir-183-5p	0-10	interleukin 1 alpha	Homo sapiens	87-95
33360372-12	2021	MiR-183-5p restoration also enhanced IL-1beta-blocked cell proliferation, and relieved IL-1beta-induced cell apoptosis and ECM degradation, while GREM1 (a target of miR-183-5p) overexpression abolished the effects of miR-183-5p restoration.	-183-5p	3-10	interleukin 1 alpha	Homo sapiens	37-45
33360372-12	2021	MiR-183-5p restoration also enhanced IL-1beta-blocked cell proliferation, and relieved IL-1beta-induced cell apoptosis and ECM degradation, while GREM1 (a target of miR-183-5p) overexpression abolished the effects of miR-183-5p restoration.	-183-5p	3-10	interleukin 1 alpha	Homo sapiens	87-95
33470533-9	2021	In the Langendorff model, PD98059 inhibited ERK1/2 and up-regulated the expression of NOX4, NLRP3, caspase-1 and IL-1beta, which exacerbated oxidative stress and inflammation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	26-33	interleukin 1 alpha	Homo sapiens	113-121
33239408-0	2021	Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1beta Production.	FTY 720P	0-20	interleukin 1 alpha	Homo sapiens	130-138
33239408-0	2021	Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1beta Production.	FTY 720P	22-30	interleukin 1 alpha	Homo sapiens	130-138
33239408-0	2021	Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1beta Production.	Uric Acid	97-113	interleukin 1 alpha	Homo sapiens	130-138
33239408-2	2021	Phagocytic uptake of MSU crystals by joint-resident macrophages and recruited circulating monocytes results in IL-1beta expression and production.	Uric Acid	21-24	interleukin 1 alpha	Homo sapiens	111-119
33239408-5	2021	We hypothesized that innate immune danger signals e.g. lipopolysaccharide (LPS) and soluble uric acid (sUA) prime human monocytes towards MSU crystal phagocytosis, and increased IL-1beta production mediated by a reduction in PP2A activity and restoring PP2A activity exerts an anti-inflammatory effect in this setting.	Uric Acid	92-101	interleukin 1 alpha	Homo sapiens	178-186
33239408-5	2021	We hypothesized that innate immune danger signals e.g. lipopolysaccharide (LPS) and soluble uric acid (sUA) prime human monocytes towards MSU crystal phagocytosis, and increased IL-1beta production mediated by a reduction in PP2A activity and restoring PP2A activity exerts an anti-inflammatory effect in this setting.	sua	103-106	interleukin 1 alpha	Homo sapiens	178-186
33239408-6	2021	Priming monocytes with LPS + sUA increased cytosolic pro-IL-1beta and mature IL-1beta and enhanced MSU crystal phagocytosis and its downstream IL-1beta expression (p<0.001).	sua	29-32	interleukin 1 alpha	Homo sapiens	57-65
33239408-6	2021	Priming monocytes with LPS + sUA increased cytosolic pro-IL-1beta and mature IL-1beta and enhanced MSU crystal phagocytosis and its downstream IL-1beta expression (p<0.001).	sua	29-32	interleukin 1 alpha	Homo sapiens	77-85
33239408-8	2021	PP2A catalytic subunit gene knockdown reduced PP2A activity and exacerbated MSU crystal induced IL-1beta expression and secretion (p<0.0001).	Uric Acid	76-79	interleukin 1 alpha	Homo sapiens	96-104
33239408-11	2021	Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals.	Uric Acid	192-201	interleukin 1 alpha	Homo sapiens	128-136
33239408-11	2021	Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals.	Uric Acid	242-270	interleukin 1 alpha	Homo sapiens	128-136
33239408-11	2021	Significance Statement The activity of protein phosphatase 2A (PP2A) is implicated in the enhanced expression and production of IL-1beta by human monocytes in response to priming with soluble uric acid, lipopolysaccharide and phagocytosis of monosodium urate monohydrate (MSU) crystals.	Uric Acid	272-275	interleukin 1 alpha	Homo sapiens	128-136
33239408-12	2021	Fingolimod phosphate activates PP2A in human monocytes and reduces cytosolic pro-IL-1beta content and its conversion to biologically active IL-1beta in human monocytes exposed to MSU crystals.	FTY 720P	0-20	interleukin 1 alpha	Homo sapiens	81-89
33634616-0	2021	Hyaluronic acid reduces inflammation and crevicular fluid IL-1beta concentrations in peri-implantitis: a randomized controlled clinical trial.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	58-66
33579464-2	2021	In the present work, it was hypothesized that highly crosslinked PVA-fucoidan and PVA-carrageenan hydrogels can control permeation of the trefoil-shaped inflammatory cytokine IL-1beta while allowing the permeation of the globular protein albumin.	Carrageenan	86-97	interleukin 1 alpha	Homo sapiens	175-183
33484807-8	2021	The possible role of Desulfovibrio in gastric cancer was assessed with H2S-treated HT-29 cells, and the results showed that H2S induced NO, IL-1beta and IL-18 production, which is important for inflammation promotion and can be delivered through the bloodstream.	Deuterium	124-127	interleukin 1 alpha	Homo sapiens	140-148
33547534-10	2021	Moreover, nuclear staining for NF-kappaB and NF-kappaB target genes upregulation, IL1A and IL1B, were also observed after 5-Aza-2"-dC in normoxia.	Azacitidine	122-127	interleukin 1 alpha	Homo sapiens	82-86
32767851-9	2021	Western blotting analysis indicated that the expression of IL-1beta and p-NR1 in MDH was significantly enhanced at 3 days after ETM.	etm	128-131	interleukin 1 alpha	Homo sapiens	59-67
32767851-10	2021	Furthermore, we found that fluorocitrate administration at 3 days after ETM could markedly suppress the expression of c-Fos, GFAP, IL-1beta and p-NR1 and attenuate the reduction of PPT induced by ETM.	fluorocitrate	27-40	interleukin 1 alpha	Homo sapiens	131-139
33096205-9	2021	Expression of inflammatory cytokines (TNF-alpha, and IL-1 beta) was higher in BDDE-treated cells.	1,4-bis(2,3-epoxypropoxy)butane	78-82	interleukin 1 alpha	Homo sapiens	53-62
32805356-8	2021	The anti-inflammatory activity was evaluated by the model carrageenan-induced peritonitis with quantification of the levels of TNF-alpha and IL-1beta in the intraperitoneal fluid, and ear edema induced by croton oil.	Carrageenan	58-69	interleukin 1 alpha	Homo sapiens	141-149
32805356-12	2021	The essential oil demonstrated anti-inflammatory activity reducing levels of pro-inflammatory cytokines TNF-alpha (38.83%, 72.42% and 73.52%) and IL-1beta (37.70%, 75.92% and 87.71%), and ear edema by 49.53%, 85.04% and 94.39% at concentrations of 4, 40 and 400 mg/kg, respectively.	Oils, Volatile	4-17	interleukin 1 alpha	Homo sapiens	146-154
33542630-10	2021	The serum miR-128 levels in AD patients were positively correlated with the serum IL-1beta (r=0.798, P<0.01) and serum TNF-alpha levels (r=0.733, P<0.01).	mir-128	10-17	interleukin 1 alpha	Homo sapiens	82-90
33575345-3	2021	The aim of this study was to examine if sudachitin could decrease the expression of inflammatory mediators such as cytokines, chemokines, or matrix metalloproteinase (MMP) in interleukin- (IL-) 1beta-stimulated human periodontal ligament cells (HPDLC).	sudachitin	40-50	interleukin 1 alpha	Homo sapiens	141-199
33575345-4	2021	Sudachitin inhibited IL-1beta-induced IL-6, IL-8, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP-1, and MMP-3 production in HPDLC.	sudachitin	0-10	interleukin 1 alpha	Homo sapiens	21-29
33575345-6	2021	Moreover, we found that the nuclear factor- (NF-) kappaB and protein kinase B (Akt) pathways in the IL-1beta-stimulated HPDLC were inhibited by sudachitin treatment.	sudachitin	144-154	interleukin 1 alpha	Homo sapiens	100-108
33575345-7	2021	These findings indicate that sudachitin is able to reduce inflammatory mediator production in IL-1beta-stimulated HPDLC by inhibiting NF-kappaB and Akt pathways.	sudachitin	29-39	interleukin 1 alpha	Homo sapiens	94-102
33525735-2	2021	Although it is recognized that the lack of protein prenylation consequent to mevalonate pathway blockade drives IL1beta hypersecretion, and hence autoinflammation, MKD pathogenesis and the molecular mechanisms underlaying most of its clinical manifestations are still largely unknown.	Mevalonic Acid	77-87	interleukin 1 alpha	Homo sapiens	112-119
33499800-0	2021	Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1beta in astrocytes through inhibition of NF-kappaB and AP-1 transcription factor activation.	docosahexaenoic fatty acid	0-26	interleukin 1 alpha	Homo sapiens	76-84
33499800-4	2021	In this study we examined the mechanism involved in the inhibition of the pro-inflammatory response by DHA in astrocytes treated with IL-1beta.	Dihydroalprenolol	103-106	interleukin 1 alpha	Homo sapiens	134-142
33499800-5	2021	METHODS AND RESULTS: Activation of the transcription factors NF-kappaB and AP-1 was measured in IL-1beta-treated primary astrocytes incubated with various concentrations of DHA.	Dihydroalprenolol	173-176	interleukin 1 alpha	Homo sapiens	96-104
33502605-8	2021	Additionally, the elevated pro-inflammatory cytokine levels were counteracted after aloin treatment in cells under SI/R conditions, including TNF-alpha, IL-6, and IL-1beta.	alloin	84-89	interleukin 1 alpha	Homo sapiens	163-171
33504771-11	2021	In renal tubular epithelial cells, hypoxia/reoxygenation induced ATP release and extracellular ATP depletion reduced the expression of active IL-1beta.	Adenosine Triphosphate	95-98	interleukin 1 alpha	Homo sapiens	142-150
33584652-10	2020	Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1beta, IL-6 and IL-13 in multivariable models compared to LTBI+ non-progressors.	Terbium	41-43	interleukin 1 alpha	Homo sapiens	96-103
33530480-4	2021	Moreover, KMU-1170 suppressed LPS-induced upregulation of proinflammatory cytokines such as IL-1beta, TNF-alpha, and IL-6, and, notably, inhibited LPS-induced upregulation of the NLRP3 inflammasome in THP-1 cells.	kmu-1170	10-18	interleukin 1 alpha	Homo sapiens	92-100
33530480-5	2021	Importantly, KMU-1170 attenuated LPS-mediated inflammatory responses in human osteoarthritic FLS, such as the upregulation of IL-1beta, TNF-alpha, IL-6, iNOS, and COX-2 and the phosphorylation of IKKalpha/beta and NF-kappaB p65.	kmu-1170	13-21	interleukin 1 alpha	Homo sapiens	126-134
33246336-15	2021	MAIN RESULTS AND THE ROLE OF CHANCE: After 1-week grafting, the relative expression of Sod1, Hmox1 and Cat was significantly higher in the group receiving 150 mg/kg NAC (NAC150-treated group) compared to controls (P = 0.04, P = 0.03, and P = 0.01, respectively), whereas the expression levels of Tnf-alpha, Il1-beta and Il6 were reduced.	nac150	170-176	interleukin 1 alpha	Homo sapiens	307-315
33559428-8	2021	Silver needle plus loxoprofen sodium was more effective in reducing WOMAC score, TRACP-5b, TNF-alpha, IL-1beta level (P<0.01), and up-regulating BGP, BALP, and TGF-beta level (P<0.01) than loxoprofen.	Loxoprofen sodium	19-36	interleukin 1 alpha	Homo sapiens	102-110
33559428-8	2021	Silver needle plus loxoprofen sodium was more effective in reducing WOMAC score, TRACP-5b, TNF-alpha, IL-1beta level (P<0.01), and up-regulating BGP, BALP, and TGF-beta level (P<0.01) than loxoprofen.	loxoprofen	19-29	interleukin 1 alpha	Homo sapiens	102-110
33485352-9	2021	Baicalein significantly attenuated the inflammatory factors induced by LPS, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), matrix metalloprotein-1 (MMP-1), MMP-2 and monocyte chemoattractant protein 1 (MCP-1) at both mRNA and protein level.	baicalein	0-9	interleukin 1 alpha	Homo sapiens	105-113
33499199-4	2021	Both all trans- and 9-cis-RA suppressed production of dry eye relevant inflammatory mediators [interleukin(IL)-1beta, IL-12, regulated upon activation, normal T cell expressed and secreted (RANTES)] by myeloid cells.	trans- and 9-cis-ra	9-28	interleukin 1 alpha	Homo sapiens	94-116
33551814-3	2020	We conducted a nested case-control study by using the US Food and Drug Administration Adverse Event Reporting System database aimed at quantifying the association between the use of IL-1 inhibitors/colchicine in pregnant women and the occurrence of maternal/fetal adverse effects.	Colchicine	198-208	interleukin 1 alpha	Homo sapiens	182-186
33471105-5	2021	Leucocyte pore activity was measured by uptake of the fluorescent dye, Yo-Pro-1 and by ATP-induced interleukin (IL)-1beta release.	Adenosine Triphosphate	87-90	interleukin 1 alpha	Homo sapiens	99-121
33359047-11	2021	In short, an animal model of chemically-induced epileptic seizures was used, in which the animals were treated with doses of prednisolone, and these animals presented less severe seizures than the negative control group (saline), in addition to showing decreased levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha, in the hippocampi and prefrontal cortices, but not the sera.	Prednisolone	125-137	interleukin 1 alpha	Homo sapiens	306-314
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	96-104
33537033-7	2020	IgG, IL-1beta, and TNF-alpha in the GH-SB group were significantly downregulated compared to those in the GH group.	gh-sb	36-41	interleukin 1 alpha	Homo sapiens	5-13
33467104-5	2021	Flavocoxid induced a significant reduction in serum interleukin (IL)-1 beta and TNF-alpha only in the group of DMD boys on add-on therapy (flavocoxid added to steroids for at least six months).	flavocoxid	0-10	interleukin 1 alpha	Homo sapiens	52-75
33399849-8	2021	We also observed increased IL-1beta secretion in PBMCs from T1D patients and immortalized murine macrophages treated with advanced glycation end products and palmitic acid.	Palmitic Acid	158-171	interleukin 1 alpha	Homo sapiens	27-35
33467441-7	2021	Ibrutinib achieves a reduction in the production of TNFalpha, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process.	ibrutinib	0-9	interleukin 1 alpha	Homo sapiens	62-65
33628184-8	2020	Our in vivo experiments showed that Pristimerin remarkably ameliorated ovariectomy-induced bone loss, reduced serum levels of TNF-alpha, IL-1beta, IL-6, and RANKL, and increased serum level of osteoprotegerin (OPG).	pristimerin	36-47	interleukin 1 alpha	Homo sapiens	137-145
32683156-8	2021	The biomarkers of oxidative stress (ROS and MDA), pro-inflammation (TNF-alpha and IL-1beta), and apoptosis (NF-kappaB and Caspase-3) were all significantly increased with COF dose.	COF protocol	171-174	interleukin 1 alpha	Homo sapiens	82-90
33441600-3	2021	We next demonstrated that KH176m selectively inhibited lipopolysaccharide (LPS) or interleukin-1beta (IL-1beta)-induced PGE2 production in control skin fibroblasts.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	26-31	interleukin 1 alpha	Homo sapiens	102-110
33441600-3	2021	We next demonstrated that KH176m selectively inhibited lipopolysaccharide (LPS) or interleukin-1beta (IL-1beta)-induced PGE2 production in control skin fibroblasts.	Dinoprostone	120-124	interleukin 1 alpha	Homo sapiens	102-110
33436541-4	2021	The present study demonstrated that DHA and AA ameliorated lipopolysaccharide (LPS)-induced Kupffer cells pyroptosis by reversing the increased expression of NLRP3 inflammasome complex, GSDMD, IL-1beta, IL-18, and PI-stained positive rate.	Docosahexaenoic Acids	36-39	interleukin 1 alpha	Homo sapiens	193-201
33505496-5	2021	TACE induced significant increases of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), IL-1beta, IL-2R, IL-6, and IL-8.	Chlorotrianisene	0-4	interleukin 1 alpha	Homo sapiens	106-114
33430857-9	2021	Single LPS treatment for chondrocytes downregulated the Col II expression while upregulated the expression of IL-1beta, IL-18, and MMP-13, which was further changed by ATP treatment.	Adenosine Triphosphate	168-171	interleukin 1 alpha	Homo sapiens	110-118
33430857-12	2021	miR-107 overexpression upregulated the Col II expression while down-regulated the expression of IL-1beta, IL-18, and MMP-13 in supernatant of chondrocytes or chondrocytes induced by LPS and ATP.	Adenosine Triphosphate	190-193	interleukin 1 alpha	Homo sapiens	96-104
33435371-5	2021	ART treatment induced an increase in inflammatory monocytes (CD14highCD16-) with HLA-DR high expression and MCP-1/IL-1beta release.	Artesunate	0-3	interleukin 1 alpha	Homo sapiens	114-122
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	interleukin 1 alpha	Homo sapiens	133-146
33417619-15	2021	Meanwhile, in the Sp group, lower levels of pro-inflammatory factors IFN-gamma, IL-1beta, IL-2, IL-6, IL-7, IL-21 and TNF-alpha, in addition to higher levels of anti-inflammatory factors IL-4 and IL-5 in gingival crevicular fluid, were identified than those in the Dp group.	TFF2 protein, human	18-20	interleukin 1 alpha	Homo sapiens	80-88
33430114-7	2021	ALA significantly reduces ER-beta, NALP-3 protein expression/activity and the secretion of IL-1beta and IL-18 in both 12Z and 22B cells.	Thioctic Acid	0-3	interleukin 1 alpha	Homo sapiens	91-99
33300903-7	2021	The weaned piglets of the HMSeBA group had lower serum IL-1beta and IL-6 than the piglets of the control group at 2 h of LPS challenge.	2-hydroxy-4-methylselenobutanoic acid	26-32	interleukin 1 alpha	Homo sapiens	55-63
33325949-6	2021	In addition, TAX inhibited the expression of P2X7R, IL-1beta, and caspase-1.	taxifolin	13-16	interleukin 1 alpha	Homo sapiens	52-60
33413425-3	2021	Different concentrations of Dex were used to attenuate the inflammation induced by IL-1beta, and its effect was assessed via RT-PCR to detect inflammatory cytokine-related mRNA levels, including those of IKbeta-alpha, IKKbeta, IL-6, IL-8, and TNF-alpha.	Dexamethasone	28-31	interleukin 1 alpha	Homo sapiens	83-91
33414242-2	2021	In a predefined substudy of the original AMAZES protocol (500 mg, three times a week for 48 weeks), we report that AZM treatment reduces key sputum inflammatory proteins (interleukin (IL)-6, IL-1beta and extracellular DNA), which is more evident in non-eosinophilic asthma (NEA).	Azithromycin	115-118	interleukin 1 alpha	Homo sapiens	191-199
33414419-0	2021	Gefitinib initiates sterile inflammation by promoting IL-1beta and HMGB1 release via two distinct mechanisms.	Gefitinib	0-9	interleukin 1 alpha	Homo sapiens	54-62
33414419-3	2021	Here, we provide evidence that gefitinib elicits pro-inflammatory responses by promoting mature-interleukin-1beta (IL-1beta) and high-mobility group box 1 (HMGB1) release.	Gefitinib	31-40	interleukin 1 alpha	Homo sapiens	115-123
33414419-4	2021	Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release.	reactive oxygen	14-29	interleukin 1 alpha	Homo sapiens	178-186
33414419-4	2021	Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release.	Gefitinib	56-65	interleukin 1 alpha	Homo sapiens	178-186
33414419-7	2021	Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1beta and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis.	Gefitinib	182-191	interleukin 1 alpha	Homo sapiens	140-148
33414419-7	2021	Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1beta and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis.	Gefitinib	182-191	interleukin 1 alpha	Homo sapiens	140-148
33402173-15	2021	Moreover, isoliquiritin protected primary microglia against LPS and adenosine triphosphate (ATP) elicited NLRP3 inflammasome activation in vitro, evidenced by declined protein levels of p-NF-kappaB, NLRP3; cleaved Caspase-1, IL-1beta, and GSDMD-N; upregulated miRNA-27a mRNA expression; and decreased the mRNA and protein levels of SYK.	neoisoliquiritin	10-23	interleukin 1 alpha	Homo sapiens	225-233
33402173-15	2021	Moreover, isoliquiritin protected primary microglia against LPS and adenosine triphosphate (ATP) elicited NLRP3 inflammasome activation in vitro, evidenced by declined protein levels of p-NF-kappaB, NLRP3; cleaved Caspase-1, IL-1beta, and GSDMD-N; upregulated miRNA-27a mRNA expression; and decreased the mRNA and protein levels of SYK.	Adenosine Triphosphate	92-95	interleukin 1 alpha	Homo sapiens	225-233
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	281-289
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	nano-curcumin	13-26	interleukin 1 alpha	Homo sapiens	281-289
33406583-11	2021	The PLGA-DEX NPs (0.1 mg/kg) significantly reduced macroscopic and histopathological scores, decreased MDA, TNF-alpha and IL-1beta levels, immunostaining for NF-kappaB, COX-2, TGF-beta, and suppressed NF-kappaB p65 mRNA expression, but increased GILZ and MKP1 expression.	Dextromethorphan	9-12	interleukin 1 alpha	Homo sapiens	122-130
33360073-7	2021	Moreover, the PL-loaded composite hydrogels inhibited the inflammatory response and dedifferentiation of IL-1beta-induced chondrocytes.	pl	14-16	interleukin 1 alpha	Homo sapiens	105-113
33437169-6	2021	Results: The treatment with pCA suppressed the productions and mRNA expressions of thymic stromal lymphopoietin (TSLP), TNF-alpha, IL-6, and IL-1beta in HMC-1 cells.	p-coumaric acid	28-31	interleukin 1 alpha	Homo sapiens	141-149
33537033-13	2020	The overexpression of IgG and IL-1beta is the reason that high-dose 11S reduces serum immune function, and supplementing SB can suppress this overexpression.	5-chloroindole	68-71	interleukin 1 alpha	Homo sapiens	30-38
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c2,3,6 chitosan sulfate	162-185	interleukin 1 alpha	Homo sapiens	139-147
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c2,3,6-hacc	192-203	interleukin 1 alpha	Homo sapiens	139-147
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c3,6 chitosan sulfate-hacc	215-241	interleukin 1 alpha	Homo sapiens	139-147
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c3,6-hacc	243-252	interleukin 1 alpha	Homo sapiens	139-147
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	chitosan sulfate	169-185	interleukin 1 alpha	Homo sapiens	139-147
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c6-hacc	293-300	interleukin 1 alpha	Homo sapiens	139-147
33111436-10	2021	ROS activate the NF-kappaB signalling pathway, thus promoting NLRP3 inflammasome activation and IL-1beta release, both of which promote NP degeneration.	Reactive Oxygen Species	0-3	interleukin 1 alpha	Homo sapiens	96-104
33160017-0	2021	The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1beta and IL-18 secretion.	empagliflozin	20-33	interleukin 1 alpha	Homo sapiens	181-189
33160017-6	2021	Importantly, SMC express SGLT2, and pre-treatment with EMPA attenuated IL-17A/TRAF3IP2-dependent oxidative stress, NLRP3 expression, caspase-1 activation, IL-1beta and IL-18 secretion, and SMC proliferation and migration.	empagliflozin	55-59	interleukin 1 alpha	Homo sapiens	155-163
32895042-8	2021	RESULT: Berberine did not have any toxic effect on cells, whereas Lipopolysachharide (LPS) stimulation caused a noticeable rise in TNF-alpha and IL-1beta production.	lipopolysachharide	66-84	interleukin 1 alpha	Homo sapiens	145-153
32895042-9	2021	Berberine markedly downregulated the expression of both TNF-alpha and IL1beta and inhibits TNF-alpha and IL-1beta secretion from LPS-stimulated PBMCs.	Berberine	0-9	interleukin 1 alpha	Homo sapiens	70-77
32895042-9	2021	Berberine markedly downregulated the expression of both TNF-alpha and IL1beta and inhibits TNF-alpha and IL-1beta secretion from LPS-stimulated PBMCs.	Berberine	0-9	interleukin 1 alpha	Homo sapiens	105-113
32895042-10	2021	DISCUSSION: This study provided molecular basis for anti-inflammatory effect of berberine on human mononuclear cells through the suppression of TNF-a and IL-1secretion.	Berberine	80-89	interleukin 1 alpha	Homo sapiens	154-158
32455427-4	2021	Specifically, we provide evidence that the key diabetogenic cytokine IL-1beta disrupts functionality of the beta cell circadian clock and impairs circadian regulation of glucose-stimulated insulin secretion.	Glucose	170-177	interleukin 1 alpha	Homo sapiens	69-77
32727335-3	2021	n-3 fatty acids and curcumin revealed neuro-modulatory and anti-inflammatory effects through several pathways, of which the suppression of IL-1beta gene expression is an important inflammatory pathway.	Fatty Acids, Omega-3	0-15	interleukin 1 alpha	Homo sapiens	139-147
32727335-3	2021	n-3 fatty acids and curcumin revealed neuro-modulatory and anti-inflammatory effects through several pathways, of which the suppression of IL-1beta gene expression is an important inflammatory pathway.	Curcumin	20-28	interleukin 1 alpha	Homo sapiens	139-147
32727335-4	2021	The aim of this study was the investigation of synergistic relation of n -3 fatty acids and nano-curcumin on IL-1beta gene expression and serum levels in migraine patients.	Fatty Acids, Omega-3	71-87	interleukin 1 alpha	Homo sapiens	109-117
32727335-4	2021	The aim of this study was the investigation of synergistic relation of n -3 fatty acids and nano-curcumin on IL-1beta gene expression and serum levels in migraine patients.	nano-curcumin	92-105	interleukin 1 alpha	Homo sapiens	109-117
32966192-5	2021	RESULTS: Remission was achieved in arthritis attacks in 16 of 18 patients who started anti-IL-1 therapy because of colchicine-resistant chronic arthritis.	Colchicine	115-125	interleukin 1 alpha	Homo sapiens	91-95
32966192-7	2021	The treatment dose of colchicine was reduced with anti-IL-1 therapy.	Colchicine	22-32	interleukin 1 alpha	Homo sapiens	55-59
32966192-10	2021	CONCLUSION: Anti-IL-1 therapy is effective and reliable in the treatment of colchicine-resistant chronic FMF arthritis.	Colchicine	76-86	interleukin 1 alpha	Homo sapiens	17-21
32966192-11	2021	The efficacy of anti-IL-1 therapy was realized without concomitant disease-modifying antirheumatic drug therapy, despite the reduction in colchicine dose.	Colchicine	138-148	interleukin 1 alpha	Homo sapiens	21-25
33129922-6	2021	The serum cytokines including IFNgamma, IFNalpha2, IL-1beta, IL-2 and MIP-1beta were significantly higher in pre-nCRT serum with higher bTMB group than that of lower bTMB group.	3,5-Bis(trimethylsilyl)benzoic acid	136-140	interleukin 1 alpha	Homo sapiens	51-59
33285354-6	2021	The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased.	Uric Acid	71-74	interleukin 1 alpha	Homo sapiens	22-30
33285354-6	2021	The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased.	bcp	116-119	interleukin 1 alpha	Homo sapiens	22-30
33136175-7	2021	RESULTS: The human primary small airway epithelial cells (SAECs) treated with LTD4 showed significant alterations in the levels of inflammatory markers such as GM-CSF, TNF-alpha, IL-1beta, EGF and eotaxin in dose- and time-dependent manner.	Leukotriene D4	78-82	interleukin 1 alpha	Homo sapiens	179-187
33147588-0	2021	Upregulated ox40l Can Be Inhibited by miR-146a-5p in Condylar Chondrocytes Induced by IL-1beta and TNF-alpha: A Possible Regulatory Mechanism in Osteoarthritis.	-146a-	41-47	interleukin 1 alpha	Homo sapiens	86-94
33218942-8	2021	The expressions of TLR4/NF-kappaBp65, IL-1beta, IL-6, IL-8, and TNF-alpha significantly increased in the model group while they were down-regulated in the rebamipide pretreatment group (p < 0.05).	rebamipide	155-165	interleukin 1 alpha	Homo sapiens	38-46
33390812-5	2021	In addition, an inhibitor assay revealed that production of reactive oxygen species, P2X7R activity, and release of cathepsin B are involved in IL-1beta production in BMDCs in response to P. nigrescens.	Oxygen	69-75	interleukin 1 alpha	Homo sapiens	144-152
33832346-1	2021	This study monitored the changes in the expression of inflammatory IL-6 and IL-1beta during the treatment period of Fluoropyrimidine (FP) based therapy.	2-fluoropyrimidine	116-132	interleukin 1 alpha	Homo sapiens	76-84
33832346-1	2021	This study monitored the changes in the expression of inflammatory IL-6 and IL-1beta during the treatment period of Fluoropyrimidine (FP) based therapy.	fp	134-136	interleukin 1 alpha	Homo sapiens	76-84
33832346-6	2021	FP therapy significantly induced IL-6 and IL-1beta expression.	fp	0-2	interleukin 1 alpha	Homo sapiens	42-50
33832346-7	2021	Subgroup analysis showed that patients with right colon tumors had significant elevation in both IL-6 and IL-1beta with FP therapy.	fp	120-122	interleukin 1 alpha	Homo sapiens	106-114
33832346-8	2021	FP therapy significantly induced IL-1beta expression in patients <=45 years, smokers, with high baseline level of CA19.9, right colon tumors, low grade pathology, T3 tumors and positive lymph nodes.	fp	0-2	interleukin 1 alpha	Homo sapiens	33-41
32951264-10	2021	In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma).	crocin	13-19	interleukin 1 alpha	Homo sapiens	276-284
32951264-10	2021	In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma).	crocetin	20-28	interleukin 1 alpha	Homo sapiens	276-284
33211383-10	2021	We identified that maltol could suppress the IL-1beta-stimulated generation of PGE2 and NO.	maltol	19-25	interleukin 1 alpha	Homo sapiens	45-53
33211383-10	2021	We identified that maltol could suppress the IL-1beta-stimulated generation of PGE2 and NO.	Dinoprostone	79-83	interleukin 1 alpha	Homo sapiens	45-53
33211383-12	2021	Furthermore, maltol remarkably suppressed the phosphorylation of PI3K/AKT and NF-kappaB induced by IL-1beta in human OA chondrocytes.	maltol	13-19	interleukin 1 alpha	Homo sapiens	99-107
32761488-7	2021	Western blotting results suggested that dioscin inhibited the activation of NLRP3 through down-regulating the protein expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved-caspase-1, as well as IL-1beta.	dioscin	40-47	interleukin 1 alpha	Homo sapiens	257-265
32148148-8	2021	Pretreatment with baricitinib, which blocks IL-6 receptor signalling, prevented MSU-induced cleaved caspase-1 or IL-1beta induction in IL-6-primed neutrophils.	baricitinib	18-29	interleukin 1 alpha	Homo sapiens	113-121
32996080-9	2021	The levels of inflammatory factors (TNF-alpha, IL-1beta, and IL-6) were elevated in DPN model.	dpn	84-87	interleukin 1 alpha	Homo sapiens	47-55
33386669-7	2022	RESULTS: While conditioned media of untreated and TNF-alpha-treated GMSCs did not affect apoptosis of PMNs, it was significantly delayed by conditioned media of GMSCs treated with IL-1beta.	gmscs	68-73	interleukin 1 alpha	Homo sapiens	180-188
33386669-7	2022	RESULTS: While conditioned media of untreated and TNF-alpha-treated GMSCs did not affect apoptosis of PMNs, it was significantly delayed by conditioned media of GMSCs treated with IL-1beta.	gmscs	161-166	interleukin 1 alpha	Homo sapiens	180-188
33386669-9	2022	However, the strongest impact was observed by IL-1beta-treated GMSCs.	gmscs	63-68	interleukin 1 alpha	Homo sapiens	46-54
33386669-11	2022	CONCLUSION: This study demonstrates for the first time the immunomodulatory properties of GMSCs towards PMNs, revealing that IL-1beta enhances anti-apoptotic effects of GMSCs.	gmscs	90-95	interleukin 1 alpha	Homo sapiens	125-133
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	17-alpha-Hydroxypregnenolone	68-96	interleukin 1 alpha	Homo sapiens	55-63
33249629-2	2021	The anti-inflammatory potential of Naringenin-LCNs evaluated by qPCR revealed a decreased expression of IL-6, IL-8, IL-1beta, and TNF-alpha in lipopolysaccharide-induced BCi-NS1.1 cells.	naringenin-lcns	35-50	interleukin 1 alpha	Homo sapiens	116-124
33249629-8	2021	In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8.	naringenin	13-23	interleukin 1 alpha	Homo sapiens	104-112
33249629-8	2021	In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8.	lcns	31-35	interleukin 1 alpha	Homo sapiens	104-112
33326336-9	2021	And the inhibition effect of OXT on the expression of CGRP, IL-1beta, and TNF-alpha was abolished by pre-application of L-368,899 into the TG.	l-368	120-125	interleukin 1 alpha	Homo sapiens	60-68
33347772-6	2021	Results: GLY protected against loss of cell viability induced by HG and significantly reduced HMGB1, IL-1beta, TLR2, TLR4, NLRP3, COX2, SOD2, HO-1, GPX2, and GR1.	Glycyrrhizic Acid	9-12	interleukin 1 alpha	Homo sapiens	101-109
32964394-9	2021	However, it was found that administration of LD50 dose beta-arbutin induced inflammation in these cells via proinflammatory cytokine levels (TNF-alpha, IFN-gamma and IL-1beta).	Arbutin	55-67	interleukin 1 alpha	Homo sapiens	166-174
33184983-7	2021	Finally, resveratrol significantly reduced the serum levels of IL-1beta, CRP and PGE2 , as well as NF-kB synovial tissue expression, which showed a significant correlation with p62 expression.	Resveratrol	9-20	interleukin 1 alpha	Homo sapiens	63-71
33952842-11	2021	In addition, DOX induced the mitochondrial damage and increased the expression of Interleukin-1 (IL-1) via stress-activated protein kinases (SAPK)/ c-Jun NH-2termial kinase (JNK).	Doxorubicin	13-16	interleukin 1 alpha	Homo sapiens	82-95
33952842-11	2021	In addition, DOX induced the mitochondrial damage and increased the expression of Interleukin-1 (IL-1) via stress-activated protein kinases (SAPK)/ c-Jun NH-2termial kinase (JNK).	Doxorubicin	13-16	interleukin 1 alpha	Homo sapiens	97-101
33395574-8	2021	RESULTS: In isolated chondrocytes, mechanical loading inhibited IL-1beta mediated NO and PGE2 release.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	64-72
33391467-7	2021	The in vitro effects of MR409 on IL-1beta were examined in THP-1 cells and primary rat NP cells using ELISA, immunofluorescence, immunoblotting, and qRT-PCR.	(N-acetyl-tyr1,D-arg2)fragment 1-29 amide	24-29	interleukin 1 alpha	Homo sapiens	33-41
33427001-7	2021	In the whole analyzed population, there was a significant positive correlation between cotinine-IL1 and cotinine-CRP.	Cotinine	87-95	interleukin 1 alpha	Homo sapiens	96-99
33427001-7	2021	In the whole analyzed population, there was a significant positive correlation between cotinine-IL1 and cotinine-CRP.	Cotinine	104-112	interleukin 1 alpha	Homo sapiens	96-99
33391467-13	2021	Moreover, while upregulation of TRIM16 facilitated, and knockdown of TRIM16 suppressed, secretory autophagy-mediated IL-1beta secretion from THP-1 cells under oxidative stress, MR409 inhibited ROS-induced secretory autophagy and IL-1beta secretion by THP-1 cells as well as IL-1beta-induced pro-inflammatory and pro-catabolic effects in rat NP cells.	(N-acetyl-tyr1,D-arg2)fragment 1-29 amide	177-182	interleukin 1 alpha	Homo sapiens	117-125
33391467-13	2021	Moreover, while upregulation of TRIM16 facilitated, and knockdown of TRIM16 suppressed, secretory autophagy-mediated IL-1beta secretion from THP-1 cells under oxidative stress, MR409 inhibited ROS-induced secretory autophagy and IL-1beta secretion by THP-1 cells as well as IL-1beta-induced pro-inflammatory and pro-catabolic effects in rat NP cells.	(N-acetyl-tyr1,D-arg2)fragment 1-29 amide	177-182	interleukin 1 alpha	Homo sapiens	229-237
33391467-13	2021	Moreover, while upregulation of TRIM16 facilitated, and knockdown of TRIM16 suppressed, secretory autophagy-mediated IL-1beta secretion from THP-1 cells under oxidative stress, MR409 inhibited ROS-induced secretory autophagy and IL-1beta secretion by THP-1 cells as well as IL-1beta-induced pro-inflammatory and pro-catabolic effects in rat NP cells.	(N-acetyl-tyr1,D-arg2)fragment 1-29 amide	177-182	interleukin 1 alpha	Homo sapiens	229-237
33500734-7	2021	Results: Exposure to the PPARgamma agonist, rosiglitazone, during the second signal of NLRP3 inflammasome activation attenuated caspase-1 and IL-1beta maturation.	Rosiglitazone	44-57	interleukin 1 alpha	Homo sapiens	142-150
33353210-9	2020	Further, PEG35 ameliorated the inflammatory response induced by acute pancreatitis-derived exosomes by reducing the expression of IL1beta and p65 nuclear translocation.	peg35	9-14	interleukin 1 alpha	Homo sapiens	130-137
33998879-8	2022	Results: Transcriptomic analysis showed that the IL1beta-induced inflammatory response is robustly inhibited by WIN pretreatment.	(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone	112-115	interleukin 1 alpha	Homo sapiens	49-56
33373444-8	2021	Knockdown of CCRL2 led to decreased microglial release of IL-1beta following exposure to ssRNA40 while knockdown of RETREG1 and YWHAH resulted in increased IL-1beta release.	ssrna40	89-96	interleukin 1 alpha	Homo sapiens	58-66
33100269-2	2020	In response to encephalomyocarditis virus (EMCV) infection, resident islet macrophages release the pro-inflammatory cytokine IL-1beta, to levels that are sufficient to stimulate inducible nitric oxide synthase (iNOS) expression and production of micromolar levels of the free radical nitric oxide in neighboring beta-cells.	Nitric Oxide	188-200	interleukin 1 alpha	Homo sapiens	125-133
33100269-2	2020	In response to encephalomyocarditis virus (EMCV) infection, resident islet macrophages release the pro-inflammatory cytokine IL-1beta, to levels that are sufficient to stimulate inducible nitric oxide synthase (iNOS) expression and production of micromolar levels of the free radical nitric oxide in neighboring beta-cells.	Nitric Oxide	284-296	interleukin 1 alpha	Homo sapiens	125-133
33289541-6	2020	An interleukin (IL)-1beta stimulated OA cell model was established and treated with TFNA.	4-(Trifluoromethyl)nicotinic acid	84-88	interleukin 1 alpha	Homo sapiens	3-25
33289541-12	2020	TFNA treatment in IL-1beta-induced chondrocytes reduced apoptosis by activating the BCL2/BAX/caspase-3 pathway, inhibited oxidative stress by regulating the Nrf2/HO-1-signaling pathway, and enhanced autophagy through upregulated LC3-II, Beclin1, and Atg7.	4-(Trifluoromethyl)nicotinic acid	0-4	interleukin 1 alpha	Homo sapiens	18-26
33424854-3	2020	Transcriptomic analysis of Tregs co-cultured with MPPs revealed enhanced expression of genes stabilizing the suppressive function of Tregs as well as the activation of IL-1beta-driven pathways.	tregs	27-32	interleukin 1 alpha	Homo sapiens	168-176
33463129-8	2020	Following the treatment of U937 cells with oridonin, the expression of Gal-9, TIM-3, and IL-1beta genes was down-regulated, and the Gal-9 secretion and NF-kB phosphorylation were diminished, whereas doxorubicin increased all of these factors.	oridonin	43-51	interleukin 1 alpha	Homo sapiens	89-97
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	173-178	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Androstenedione	181-196	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Testosterone	198-210	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dihydrotestosterone	212-231	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Progesterone	114-126	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Corticosterone	247-261	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Desoxycorticosterone	263-285	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	304-309	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Hydrocortisone	310-318	interleukin 1 alpha	Homo sapiens	55-63
33375871-6	2021	The increased TNF-alpha, IL-1beta, and IL-6 productions in OGD/R-induced hippocampal neurons were decreased after treatment with JZL184.	JZL 184	129-135	interleukin 1 alpha	Homo sapiens	25-33
33456483-6	2020	To determine how aldosterone (Aldo) activated the mineralocorticoid receptor (MR) and then induced mesangial cell pyroptosis with NLRP3-caspase-1-IL-1beta pathway, human mesangial cells (HMCs) were treated with HJHR and eplerenone, which were examined to detect the expression of NLRP3 inflammasome-associated proteins following treatment with Aldo.	Aldosterone	30-34	interleukin 1 alpha	Homo sapiens	146-154
33371832-7	2021	Furthermore, NAC decreases TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19.	Acetylcysteine	13-16	interleukin 1 alpha	Homo sapiens	38-46
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	interleukin 1 alpha	Homo sapiens	172-180
33414782-7	2020	Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1beta and IL-18 secretion.	gm28309	18-25	interleukin 1 alpha	Homo sapiens	120-128
33414782-7	2020	Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1beta and IL-18 secretion.	mir-3068	43-51	interleukin 1 alpha	Homo sapiens	120-128
33157101-5	2020	At the molecular level, neferine could significantly alleviate the interleukin 1beta (IL-1beta)-induced mRNA and protein expression of intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1).	neferine	24-32	interleukin 1 alpha	Homo sapiens	86-94
33332241-6	2021	In this study, melatonin attenuated the expression of pyroptosis-related genes, including NLRP3, caspase-1 and IL-1beta, in human umbilical vein endothelial cells treated with oxidised low-density lipoprotein.	Melatonin	15-24	interleukin 1 alpha	Homo sapiens	111-119
33335246-5	2020	The AHLPP mixture could downregulate representative pro-inflammatory cytokines including IL 1-beta and IL 7.	ahlpp	4-9	interleukin 1 alpha	Homo sapiens	89-98
33007323-4	2020	In this study, lipopolysaccharides (LPS)-induced monocytes, lymphocytes, and monocyte-derived dendritic cells (MDDCs) as representative cells for both innate and adaptive immunity were treated with kefiran for 2 h. Kefiran had an anti-inflammatory effect on monocytes to reduce pro-inflammatory cytokines, interleukin 1 beta (IL-1beta) & tumor necrosis factor alpha (TNF-alpha), as well as nuclear factor kappa b (NF-kb).	kefir grain polysaccharide	198-205	interleukin 1 alpha	Homo sapiens	326-334
32931836-3	2020	In this research, nucleic acid aptamer LA27, which was previously selected and optimized by our group, was used as an LPS inhibitor to treat human HepG2 cells stimulated by LPS from four different sources (StLPS, EcoliLPS, PaLPS, and SeLPS): the levels of expression of three inflammatory cytokines factors (TNF-alpha, IL-1beta, and IL-6) were evaluated by ELISA on LA27-treated and untreated cells incubated for 12 h with LPS.	la27	39-43	interleukin 1 alpha	Homo sapiens	319-327
33318544-5	2020	The IL-1beta release was mediated by the NLRP3 inflammasome and by serine proteases in an NF-kappaB-and cathepsin B-dependent manner.	Serine	67-73	interleukin 1 alpha	Homo sapiens	4-12
33363539-12	2020	The inhibition of neutrophil ROS production only partly correlated with the inhibition of IL-1beta production by peripheral blood mononuclear cells (PBMCs): LDL inhibited IL-1beta production in response to large MSU crystals, but not small MSU or silica crystals.	Reactive Oxygen Species	29-32	interleukin 1 alpha	Homo sapiens	171-179
33363539-12	2020	The inhibition of neutrophil ROS production only partly correlated with the inhibition of IL-1beta production by peripheral blood mononuclear cells (PBMCs): LDL inhibited IL-1beta production in response to large MSU crystals, but not small MSU or silica crystals.	Uric Acid	212-215	interleukin 1 alpha	Homo sapiens	90-98
33363539-12	2020	The inhibition of neutrophil ROS production only partly correlated with the inhibition of IL-1beta production by peripheral blood mononuclear cells (PBMCs): LDL inhibited IL-1beta production in response to large MSU crystals, but not small MSU or silica crystals.	Uric Acid	212-215	interleukin 1 alpha	Homo sapiens	171-179
33463132-9	2020	The serum concentration of IL-1beta, IL-6, and IL-8 was significantly higher in children with steroid-sensitive nephrotic syndrome (SSNS), compared with steroid-resistant nephrotic syndrome (SRNS).	Steroids	94-101	interleukin 1 alpha	Homo sapiens	27-35
33463132-9	2020	The serum concentration of IL-1beta, IL-6, and IL-8 was significantly higher in children with steroid-sensitive nephrotic syndrome (SSNS), compared with steroid-resistant nephrotic syndrome (SRNS).	Steroids	153-160	interleukin 1 alpha	Homo sapiens	27-35
33463132-11	2020	Our findings suggested the pathogenic role of pro-inflammatory cytokines in children with INS, of which IL-1beta, IL-6, and IL-8 were accurate biomarkers for the prediction of steroid response in these patients.	Steroids	176-183	interleukin 1 alpha	Homo sapiens	104-112
33425869-12	2020	Moreover, hBMSC-EVs attenuate IL-1beta-induced reduction of chondrocyte migration.	hbmsc-evs	10-19	interleukin 1 alpha	Homo sapiens	30-38
33425869-15	2020	In addition, the phosphorylation status of Erk1/2, PI3K/Akt, p38, TAK1, and NF-kappaB signaling molecules, induced by IL-1beta, is prevented by hBMSC- EVs.	hbmsc- evs	144-154	interleukin 1 alpha	Homo sapiens	118-126
32516360-10	2020	Of note, either nicotine treatment or activation of AMPK by intracerebroventricular infusion of metformin reduced LPS-induced impairment of fear memory reconsolidation, and ameliorated inflammation factor TNF-alpha and IL-1beta as well as the expression of CRTC1.	Metformin	96-105	interleukin 1 alpha	Homo sapiens	219-227
33007323-7	2020	Kefiran balanced MDDCs secretion of pro/anti-inflammatory cytokines by reducing and enhancing the expression of IL-1beta and interleukin 10 (IL-10), respectively.	kefir grain polysaccharide	0-7	interleukin 1 alpha	Homo sapiens	112-120
33354576-4	2020	Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells.	Mercury	136-138	interleukin 1 alpha	Homo sapiens	147-155
32972972-3	2020	Furthermore, IL-1 is known to stimulate beta-cell expression of iNOS and production of the free radical nitric oxide.	Free Radicals	91-103	interleukin 1 alpha	Homo sapiens	13-17
33324092-10	2020	Intraarticular injection of the IFX-loaded F127-HA-PGA hydrogel could alleviate the expression of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-17 (IL-17), in the synovial fluid and cartilage as well as relieve pain and inhibit cartilage destruction in RA.	f127-ha-pga	43-54	interleukin 1 alpha	Homo sapiens	190-198
33354576-0	2020	Tangeretin Inhibition of High-Glucose-Induced IL-1beta, IL-6, TGF-beta1, and VEGF Expression in Human RPE Cells.	tangeretin	0-10	interleukin 1 alpha	Homo sapiens	46-54
33354576-0	2020	Tangeretin Inhibition of High-Glucose-Induced IL-1beta, IL-6, TGF-beta1, and VEGF Expression in Human RPE Cells.	Glucose	30-37	interleukin 1 alpha	Homo sapiens	46-54
33354576-4	2020	Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells.	Mercury	29-31	interleukin 1 alpha	Homo sapiens	47-55
33354576-4	2020	Our results illustrated that HG levels induced IL-1beta, IL-6, TGF-beta1, and VEGF expression and that tangeretin significantly reduced HG-induced IL-1beta, IL-6, TGF-beta1, and VEGF expression in human RPE cells.	tangeretin	103-113	interleukin 1 alpha	Homo sapiens	147-155
32972972-3	2020	Furthermore, IL-1 is known to stimulate beta-cell expression of iNOS and production of the free radical nitric oxide.	Nitric Oxide	104-116	interleukin 1 alpha	Homo sapiens	13-17
33287198-4	2020	According to the results, PGFE suppressed pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6, and pro-inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2 through heme oxygenase-1 expression in human periodontal ligament cells stimulated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS).	pgfe	26-30	interleukin 1 alpha	Homo sapiens	106-128
32583615-3	2020	Extracellular ATP contributed to the NLRP3 inflammasome-mediated IL-1beta release, which in turn was preferentially skewed toward Th17 differentiation via enhanced phosphorylation of STAT3.	Adenosine Triphosphate	14-17	interleukin 1 alpha	Homo sapiens	65-73
32867575-8	2020	Moreover, both the ELISA and gene expression analysis demonstrated down regulations of inflammatory markers (IL1-beta, TNF-alpha, p65, p50, MMP13) in Daphne mucronata preconditioned hADMSCs as compared to stress.	mucronata	157-166	interleukin 1 alpha	Homo sapiens	109-117
32638534-9	2020	Nicotine decreased the IL-1beta-induced IL-6 and MMP expression, in a dose-dependent manner, in WT chondrocytes but not in Chrna7-/- chondrocytes.	Nicotine	0-8	interleukin 1 alpha	Homo sapiens	23-31
33017186-7	2020	Finally, TMP195 inhibited LPS-induced upregulation of multiple proinflammatory cytokines/chemokines, including ICAM-1, MCP-1, TNF-alpha, and IL-1beta and accumulation of inflammatory cells in the injured kidney.	TMP195	9-15	interleukin 1 alpha	Homo sapiens	141-149
32098511-8	2020	Doxofylline inhibits LPS-induced NLRP3-TXNIP inflammasome activation as revealed by its inhibitive effect on NLRP3, caspase 1 (P10 unit), and TXNIP induction as well as weakened induction of IL-1beta and IL-18.	doxofylline	0-11	interleukin 1 alpha	Homo sapiens	191-199
33147850-9	2020	In A549 cells, Coronil attenuated the IL-1beta induced IL-6 and TNF-alpha cytokine secretions, and decreased TNF-alpha induced NF-kappaB/AP-1 transcriptional activity.	coronil	15-22	interleukin 1 alpha	Homo sapiens	38-46
32931773-7	2020	Consistent with these results, CyM diminished the expression of inflammatory genes (COX-2, TNF-alpha, IL-1beta, and IL-6), AP-1-Luc activity, and phosphorylation of Ras-mediated signaling enzymes in Ras-overexpressing HEK 293 cells.	cysmethynil	31-34	interleukin 1 alpha	Homo sapiens	102-110
33011160-8	2020	Rosmarinic acid abrogated TXNIP protein upregulation and the interaction between TXNIP and NLRP3 to attenuate NLRP3 inflammasome assembly and activation and eventually IL-1beta secretion in ECs through downregulating ROS production, p38 phosphorylation and FOXO1 protein induction in ECs.	rosmarinic acid	0-15	interleukin 1 alpha	Homo sapiens	168-176
33113418-9	2020	Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1beta, IL-6, IL-8 and TNF-alpha.	astaxanthine	47-50	interleukin 1 alpha	Homo sapiens	144-152
32898504-7	2020	We found that HL-1 cardiomyocytes moderately expressed the GLP-1 receptor, and co-treatment with Liraglutide ameliorated IL-1beta-induced cellular ROS production and NADPH oxidase (NOX)-4 expression.	ros	147-150	interleukin 1 alpha	Homo sapiens	121-129
32898504-8	2020	Furthermore, we found that Liraglutide protected cardiomyocytes from IL-1beta-induced decreased mitochondrial membrane potential and reduced ATP production.	Adenosine Triphosphate	141-144	interleukin 1 alpha	Homo sapiens	69-77
32898504-10	2020	Additionally, we found that Liraglutide alleviated IL-1beta-induced aberrant triglyceride accumulation and adiponectin secretion.	Triglycerides	77-89	interleukin 1 alpha	Homo sapiens	51-59
32898504-12	2020	Finally, through the study we demonstrated that the blockage of AMPK activity by Compound C abolished the ameliorative effect of Liraglutide on IL-1beta-induced repressed ATP production and triglyceride accumulation, indicating that the action of Liraglutide was dependent on AMPK activation.	Adenosine Triphosphate	171-174	interleukin 1 alpha	Homo sapiens	144-152
32898504-12	2020	Finally, through the study we demonstrated that the blockage of AMPK activity by Compound C abolished the ameliorative effect of Liraglutide on IL-1beta-induced repressed ATP production and triglyceride accumulation, indicating that the action of Liraglutide was dependent on AMPK activation.	Triglycerides	190-202	interleukin 1 alpha	Homo sapiens	144-152
33357720-5	2020	Additionally, TCDCA decreased tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-8 and IL-12 through nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) activity.	Taurochenodeoxycholic Acid	14-19	interleukin 1 alpha	Homo sapiens	91-99
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	lcns	67-71	interleukin 1 alpha	Homo sapiens	225-233
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	interleukin 1 alpha	Homo sapiens	225-233
33254688-7	2020	In addition, increased NLRP3 aggregation and enhanced production of IL-1beta occurred after PFOA treatment.	perfluorooctanoic acid	92-96	interleukin 1 alpha	Homo sapiens	68-76
33095981-4	2020	Here, we report that ROCK inhibition by Y-27632 reduces levels of IL-1alpha, IL-1beta, IL-6 and IL-8 secreted by senescent normal and dysplastic oral keratinocytes without affecting the permanent cell growth arrest.	Y 27632	40-47	interleukin 1 alpha	Homo sapiens	66-75
33095981-4	2020	Here, we report that ROCK inhibition by Y-27632 reduces levels of IL-1alpha, IL-1beta, IL-6 and IL-8 secreted by senescent normal and dysplastic oral keratinocytes without affecting the permanent cell growth arrest.	Y 27632	40-47	interleukin 1 alpha	Homo sapiens	77-85
33045867-8	2020	Moreover, vitexin decreased expression of interleukin-1beta (IL-1beta), IL-17A and ROS in melanocytes induced by H2O2.	Hydrogen Peroxide	113-117	interleukin 1 alpha	Homo sapiens	61-69
33049493-0	2020	The dipeptidyl peptidase (DPP)-4 inhibitor trelagliptin inhibits IL-1beta-induced endothelial inflammation and monocytes attachment.	trelagliptin	43-55	interleukin 1 alpha	Homo sapiens	65-73
33049495-8	2020	Juglanin also inhibits the inflammatory response by suppressing OSS-induced expressions of IL-1beta, MCP-1, and HMGB1.	juglanin	0-8	interleukin 1 alpha	Homo sapiens	91-99
33129099-8	2020	After treatment with Nano-curcumin, a significant decrease in IL-6 expression and secretion in serum and in supernatant (P = 0.0003, 0.0038, and 0.0001, respectively) and IL-1beta gene expression and secretion level in serum and supernatant (P = 0.0017, 0.0082, and 0.0041, respectively) was observed.	nano-curcumin	21-34	interleukin 1 alpha	Homo sapiens	171-179
33129099-10	2020	CONCLUSION: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1beta and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery.	Curcumin	17-25	interleukin 1 alpha	Homo sapiens	151-159
32809969-6	2020	In a single treated patient, we also evaluated the alteration of myeloid cell functional activity.RESULTSWe provide evidence that patients treated with baricitinib had a marked reduction in serum levels of IL-6, IL-1beta, and TNF-alpha, a rapid recovery of circulating T and B cell frequencies, and increased antibody production against the SARS-CoV-2 spike protein, all of which were clinically associated with a reduction in the need for oxygen therapy and a progressive increase in the P/F (PaO2, oxygen partial pressure/FiO2, fraction of inspired oxygen) ratio.CONCLUSIONThese data suggest that baricitinib prevented the progression to a severe, extreme form of the viral disease by modulating the patients" immune landscape and that these changes were associated with a safer, more favorable clinical outcome for patients with COVID-19 pneumonia.TRIAL REGISTRATIONClinicalTrials.gov NCT04438629.FUNDINGThis work was supported by the Fondazione Cariverona (ENACT Project) and the Fondazione TIM.	baricitinib	152-163	interleukin 1 alpha	Homo sapiens	212-220
32781854-7	2020	Moreover, KM6 reduced the levels of inflammation markers PGE2, COX2, IL-1beta and IL6 and metastasis markers MMP-2 and MMP-9.	km6	10-13	interleukin 1 alpha	Homo sapiens	69-77
32998017-8	2020	Knockdown of miR-370-3p inhibited the expression of HMGB1 and suppressed the proliferation but promoted the apoptosis of HK-2 cells injured by LPS as well as the expression of TNF-alpha, IL-6 and IL-1beta.	mir-370-3p	13-23	interleukin 1 alpha	Homo sapiens	196-204
33038372-4	2020	KEY FINDINGS: Data indicated that high glucose increased the expression of interleukin-1beta (IL-1beta), an upstream regulator of nuclear factor-kappaB (NF-kappaB) pathway, through the nuclear localization of NF-kappaB.	Glucose	39-46	interleukin 1 alpha	Homo sapiens	94-102
31971852-5	2020	Treatment with oridonin for 24 h increased apoptosis by 4.1%, and increased the protein levels of Bax and cleaved caspase-3 but significantly decreased the levels of IL-1beta in the culture supernatant (p < 0.05).	oridonin	15-23	interleukin 1 alpha	Homo sapiens	166-174
33259490-6	2020	Forskolin repressed the IL-1beta-induced increase in OTR mRNA and protein levels in a PKA-dependent fashion and repressed IL-1beta-activation and nuclear transfer of NFkappaB and AP-1.	Colforsin	0-9	interleukin 1 alpha	Homo sapiens	24-32
33259490-6	2020	Forskolin repressed the IL-1beta-induced increase in OTR mRNA and protein levels in a PKA-dependent fashion and repressed IL-1beta-activation and nuclear transfer of NFkappaB and AP-1.	Colforsin	0-9	interleukin 1 alpha	Homo sapiens	122-130
33155081-5	2020	Further, HG + SP + CORT elevated TNF-alpha, IL-1beta, free Ca2+, and ERK1/2 phosphorylation levels, which was inhibited by DHM or P2X7 shRNA treatment.	dihydromyricetin	123-126	interleukin 1 alpha	Homo sapiens	44-52
33328008-2	2020	Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor.	Serine	158-164	interleukin 1 alpha	Homo sapiens	293-306
33180478-7	2020	VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL.	valyl-prolyl-proline	0-3	interleukin 1 alpha	Homo sapiens	96-104
33180478-7	2020	VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL.	isoleucyl-prolyl-proline	8-11	interleukin 1 alpha	Homo sapiens	96-104
33255431-2	2020	P2X7 receptor (P2X7R) stimulation by extracellular ATP is best known to active the NLRP3 inflammasome and release IL-1beta, but stimulation also leads to release of other cytokines.	Adenosine Triphosphate	51-54	interleukin 1 alpha	Homo sapiens	114-122
33218208-3	2020	We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFkappaB, an event that did not occur if cells were treated with Laquinimod, indicating a direct anti-inflammatory activity of the drug on the human astrocyte.	laquinimod	202-212	interleukin 1 alpha	Homo sapiens	84-87
33208864-8	2020	Among the different tear cytokines analysed, a significant reduction after three days of treatment was detected for pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-8 and TNF-alpha, prior to starting with the administration of steroid drops.	Steroids	230-237	interleukin 1 alpha	Homo sapiens	143-151
32882369-10	2020	However, topical 5% terbinafine treatment in the Chip2 upregulated IL-1alpha in the RHS, unbalanced apoptotic and proliferative cell ratios in the liver and significantly increased its expression of CYP1A2 and 3A4 enzymes (p < 0.05), proving that it has passed the RHS barrier promoting a liver impact.	Terbinafine	20-31	interleukin 1 alpha	Homo sapiens	67-76
33170220-10	2021	Following exposure to deoxynivalenol, the secretion of interleukin (IL)-1beta, IL-6, IL-8, and/or tumor necrosis factor (TNF)-alpha in BEAS-2B cells, as well as EoL-1 cells, increased significantly.	deoxynivalenol	22-36	interleukin 1 alpha	Homo sapiens	55-77
33155879-8	2021	The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-alpha.	Curcumin	15-23	interleukin 1 alpha	Homo sapiens	95-113
33136275-7	2022	HBMVECs were injured by exposure to glucose and/or hypoxia, as assessed by release of LDH, interleukin (IL)-1beta, and reactive oxygen species (ROS).	Glucose	36-43	interleukin 1 alpha	Homo sapiens	91-113
33138862-14	2020	The knock-down of COX-2 in ASCs and the use of IL-1beta-activated ASC-conditioned media confirmed the key role of PGE2 in ASC-mediated myeloid modulation.	Dinoprostone	114-118	interleukin 1 alpha	Homo sapiens	47-55
33363521-7	2020	Butyrate administration significantly decreased LPS-induced rise in the clinical score of piglets and colonic histological scores and reduced the susceptibility to LPS-induced severe inflammatory response by decreasing proinflammatory (IL-1beta, IL-6, IL-8, and TNF-alpha) cytokines.	Butyrates	0-8	interleukin 1 alpha	Homo sapiens	236-244
33269450-4	2020	Phosprenyl, on the contrary, increased production of IL-1beta and the levels of IL-6 and IL-10.	phosprenyl	0-10	interleukin 1 alpha	Homo sapiens	53-61
33022360-6	2020	It was observed that Imatinib could function as an immunomodulator by breaking the feed-back loop between the proinflammatory cytokines (IL-1beta and TNF-alpha) and transcription factors (NF-kappaB, Jak3/Stat3) knowingly involved in increased cell proliferation during tumorigenesis via activating different intracellular signaling.	Imatinib Mesylate	21-29	interleukin 1 alpha	Homo sapiens	137-145
33002553-7	2020	CONCLUSION: In patients with T2DM and symptomatic CAD, the addition of Vildagliptin to ongoing metformin showed better glycemic control, lower inflammatory markers (IL-1beta and hsCRP), higher protective markers (adiponectin and HDL-C) and improved lipid profile compared to Glimepiride/metformin therapy.	Vildagliptin	71-83	interleukin 1 alpha	Homo sapiens	165-173
33011237-10	2020	Single treatment of sPLA2-IIa, IL-1beta or TNF-alpha of HCjE cells induced minimal to no PGE2 production.	Dinoprostone	89-93	interleukin 1 alpha	Homo sapiens	31-39
33011237-11	2020	When sPLA2-IIa was added to HCjE cells that were pre-treated with pro-inflammatory cytokines (TNF-alpha or IL-1beta), significant stimulation of PGE2 production was observed, concurrent with the extensive transcriptional changes of many inflammatory cytokines/chemokines and their receptors.	Dinoprostone	145-149	interleukin 1 alpha	Homo sapiens	107-115
33045562-5	2020	The results showed that the in vitro treatment of monocytes from preeclamptic women with Sb downregulated the endogenous activation of NF-kappaB and the expression of surface receptors TLR4 and CD64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (IL-1beta), IL-6, IL-8, IL-12p70, IL-23, and tumour necrosis factor alpha (TNF-alpha) compared with cultures not treated with Sb.	Silybin	89-91	interleukin 1 alpha	Homo sapiens	260-273
33045562-5	2020	The results showed that the in vitro treatment of monocytes from preeclamptic women with Sb downregulated the endogenous activation of NF-kappaB and the expression of surface receptors TLR4 and CD64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (IL-1beta), IL-6, IL-8, IL-12p70, IL-23, and tumour necrosis factor alpha (TNF-alpha) compared with cultures not treated with Sb.	Silybin	89-91	interleukin 1 alpha	Homo sapiens	275-283
33096361-4	2020	In in-vitro experiments, the protective effect of aloin on the anabolism and catabolism of the extracellular matrix (ECM) induced by IL-1 beta in chondrocytes by inhibiting the expression of pro-inflammatory factors, including TNF-alpha (p = 0.016), IL-6 (p = 0.006), iNOS (p = 0.001) and COX-2 (p = 0.006).	alloin	50-55	interleukin 1 alpha	Homo sapiens	133-142
33096361-5	2020	Mechanistically, Aloin suppressed the IL-1beta-induced activation of the PI3K/Akt/NF-kappaB signalling pathway cascades.	alloin	17-22	interleukin 1 alpha	Homo sapiens	38-46
33145937-8	2020	Moreover, miR-223-3p showed a notable inhibitory effect on recombinant Tp17 (rTP17)-induced caspase-1 activation, resulting in decrease in IL-1beta production and pyroptosis, which was accompanied by the release of lactate dehydrogenase (LDH) in HUVECs.	mir-223-3p	10-20	interleukin 1 alpha	Homo sapiens	139-147
33245573-8	2020	Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1beta in alcohol use disorder patients with ALD and were increased in Camp-/- mice fed alcohol.	Uric Acid	16-25	interleukin 1 alpha	Homo sapiens	128-136
33245573-8	2020	Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1beta in alcohol use disorder patients with ALD and were increased in Camp-/- mice fed alcohol.	Alcohols	140-147	interleukin 1 alpha	Homo sapiens	128-136
32998017-10	2020	SIGNIFICANCE: Paclitaxel could protect against LPS-induced AKI via the regulation of lnc-MALAT1/miR-370-3p/HMGB1 axis and the expression of TNF-alpha, IL-6 and IL-1beta, revealing that paclitaxel might act as a therapy drug in reducing sepsis-associated AKI.	Paclitaxel	14-24	interleukin 1 alpha	Homo sapiens	160-168
32642876-9	2020	However, increased sulfhydryl groups, GSH and IL-10 levels as well as reduced of proinflammatory cytokine (TNF-alpha and IL-1beta) levels were found for RA-treated groups.	rosmarinic acid	153-155	interleukin 1 alpha	Homo sapiens	121-129
33248590-6	2020	These results suggested that dietary COS supplementation had beneficial effects on intestinal morphology by increasing jejunum and ileum VH; permeability by decreasing serum DAO activity and D-LA content; antioxidant capacity by decreasing duodenum and jejunum mucosal MDA content and by increasing duodenum and jejunum GSH-Px activity; and inflammatory response by decreasing duodenum and jejunum mucosal IL-1beta content.	carbonyl sulfide	37-40	interleukin 1 alpha	Homo sapiens	406-414
32860071-8	2020	Heroin withdrawal also induces a time-dependent, region-specific increase in IL-1beta and glial fibrillary acidic protein (GFAP) immunoreactivity within the dentate gyrus of the DH.	Heroin	0-6	interleukin 1 alpha	Homo sapiens	77-85
32860071-11	2020	Collectively, our data suggests heroin withdrawal is sufficient to produce enhanced fear learning, astrocytes may play a role in heroin withdrawal-induced IL-1beta, and DH IL-1 signaling during withdrawal mediates the development of heroin withdrawal-enhanced fear learning.	Heroin	129-135	interleukin 1 alpha	Homo sapiens	155-163
32860071-11	2020	Collectively, our data suggests heroin withdrawal is sufficient to produce enhanced fear learning, astrocytes may play a role in heroin withdrawal-induced IL-1beta, and DH IL-1 signaling during withdrawal mediates the development of heroin withdrawal-enhanced fear learning.	Heroin	129-135	interleukin 1 alpha	Homo sapiens	155-163
32556219-9	2020	Patients with creatinine levels below 1.5 mg/dl at onset benefitted more from IL-1 inhibition with regard to their kidney functions and acute phase reactants.	Creatinine	14-24	interleukin 1 alpha	Homo sapiens	78-82
34056129-11	2020	LDH, IL-1beta, and IL-6 levels were higher in the DHS group compared with the other two groups at 3 months after surgery (P<0.05).	dhs	50-53	interleukin 1 alpha	Homo sapiens	5-13
33263631-4	2020	Moreover, the correlation between the level of bilirubin and serum expression of IL-1beta or TGF-beta in BE patients was analyzed.	Bilirubin	47-56	interleukin 1 alpha	Homo sapiens	81-89
33263631-6	2020	RESULTS: IL-1beta and TGF-beta levels were higher in the serum of BE patients than those in non-BE patients, and the expression of either IL-1beta or TGF-beta showed a strong positive correlation with the serum expression of bilirubin in BE patients.	Bilirubin	225-234	interleukin 1 alpha	Homo sapiens	138-146
33252790-6	2022	IL-10/IL-1beta and IFN-gamma/IL-4 ratios were reduced in GAgP dyads, suggesting a familial trend in the subgingival cytokine"s profile.	gagp	57-61	interleukin 1 alpha	Homo sapiens	6-14
33324330-6	2020	Second messengers, cAMP and calcium, are triggered by TAAR1 activation, which is upregulated by IL-1beta METH-mediated increases in these second messengers and signal transduction pathways have not been shown to directly decrease astrocyte EAAT-2.	Cyclic AMP	19-23	interleukin 1 alpha	Homo sapiens	96-104
33324330-6	2020	Second messengers, cAMP and calcium, are triggered by TAAR1 activation, which is upregulated by IL-1beta METH-mediated increases in these second messengers and signal transduction pathways have not been shown to directly decrease astrocyte EAAT-2.	Calcium	28-35	interleukin 1 alpha	Homo sapiens	96-104
33324330-6	2020	Second messengers, cAMP and calcium, are triggered by TAAR1 activation, which is upregulated by IL-1beta METH-mediated increases in these second messengers and signal transduction pathways have not been shown to directly decrease astrocyte EAAT-2.	Methamphetamine	105-109	interleukin 1 alpha	Homo sapiens	96-104
33215957-3	2020	GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells.	glutathione trisulfide	0-5	interleukin 1 alpha	Homo sapiens	48-70
33208151-11	2020	CONCLUSION: Overall results demonstrate that 3 months of Tat exposure increased morphine tolerance and potentially innate immune tolerance evidenced by reductions in specific cytokines (e.g., IL-1alpha, IL-12p40) and microglial reactivity.	Triethylenemelamine	57-60	interleukin 1 alpha	Homo sapiens	192-201
33203651-0	2021	Laquinimod dampens IL-1beta signaling and Th17-polarizing capacity of monocytes in patients with MS.	laquinimod	0-10	interleukin 1 alpha	Homo sapiens	19-27
33203651-9	2021	LPS-stimulated monocytes of laquinimod-treated patients with MS secreted less IL-1beta following a downregulation of IL-1beta gene expression.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	78-86
33203651-9	2021	LPS-stimulated monocytes of laquinimod-treated patients with MS secreted less IL-1beta following a downregulation of IL-1beta gene expression.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	117-125
33245731-8	2020	TMPRSS2, inflammatory cytokines G-CSF, M-CSF, IL-1alpha, IL-6 and MCP-1 are suppressed by MEKi alone or with remdesivir.	remdesivir	109-119	interleukin 1 alpha	Homo sapiens	46-55
33207682-6	2020	Increased levels of proinflammatory cytokines and chemokines (IL-6, IL-8, IL-1beta) were also detected in ZIKV-infected hNPCs, while z-VAD-fmk-induced inhibition of cell death suppressed ZIKV-mediated cytokine production in a dose-dependent manner.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	133-142	interleukin 1 alpha	Homo sapiens	74-82
33172487-8	2020	Ex vivo apabetalone treatment countered cytokine secretion by DM2 + CVD monocytes at baseline (GROalpha and IL-8) and during IFNgamma stimulation (IL-1beta and TNFalpha).	apabetalone	8-19	interleukin 1 alpha	Homo sapiens	147-155
33174289-8	2021	Compared with the formulation with methyl paraben (0.2%), the formulation to which 1,2-decanediol (0.05%) was added improved the antibacterial activity against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes; however, no interleukin-1alpha upregulation was observed.	1,2-decanediol	83-97	interleukin 1 alpha	Homo sapiens	245-263
33073278-2	2020	In the present work, interactions of ILs, namely, 1-butyl 3-methylimidazolium methyl sulfate (IL1), 1-butyl 3-methylimidazolium octyl sulfate (IL2) and 1-butyl 3-methylimidazolium chloride (IL3) with hen egg white lysozyme (HEWL) protein were investigated using solution-state nuclear magnetic resonance (NMR) spectroscopy.	1-butyl-3-methylimidazolium chloride	50-92	interleukin 1 alpha	Homo sapiens	94-97
33140671-14	2022	Additionally, TET promoted macrophage transformation from M1 to M2 in osteoporotic and inhibited the production of IL-1beta, TNF-alpha, and IL-6.	tetrandrine	14-17	interleukin 1 alpha	Homo sapiens	115-123
32806879-8	2020	Experience of IL-1 antagonists, anakinra and canakinumab, is now available in thousands of colchicine resistant or intolerant FMF patients.	Colchicine	91-101	interleukin 1 alpha	Homo sapiens	14-18
32699039-7	2020	Both glucose deprivation and treatment with either 2-deoxyglucose or GLUT1 inhibitor suppressed crystal-induced NLRP3 activation and IL-1beta production, and microcrystal inflammation in vivo.	Deoxyglucose	51-65	interleukin 1 alpha	Homo sapiens	133-141
32857620-0	2020	Azithromycin Downregulates Gene Expression of IL-1beta and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2.	Azithromycin	0-12	interleukin 1 alpha	Homo sapiens	46-54
32857620-11	2020	CONCLUSIONS: This proof of concept demonstrates azithromycin downregulates pathways involving serine proteases TMPRSS2 and TMPRSS11D required for SARS-CoV-2 activation and its cell-to-cell transmission while downregulating pro-inflammatory cytokine IL-1beta, NDST-1 and their associated pathways.	Azithromycin	48-60	interleukin 1 alpha	Homo sapiens	249-257
32857620-11	2020	CONCLUSIONS: This proof of concept demonstrates azithromycin downregulates pathways involving serine proteases TMPRSS2 and TMPRSS11D required for SARS-CoV-2 activation and its cell-to-cell transmission while downregulating pro-inflammatory cytokine IL-1beta, NDST-1 and their associated pathways.	Serine	94-100	interleukin 1 alpha	Homo sapiens	249-257
32699039-1	2020	OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively.	Uric Acid	36-52	interleukin 1 alpha	Homo sapiens	112-134
32699039-1	2020	OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively.	Uric Acid	54-57	interleukin 1 alpha	Homo sapiens	112-134
32699039-8	2020	CONCLUSION: In conclusion, we demonstrated that GLUT1-mediated glucose uptake is instrumental during the inflammatory IL-1beta response induced by MSU and CPP crystals.	Glucose	63-70	interleukin 1 alpha	Homo sapiens	118-126
32699039-1	2020	OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively.	Calcium Pyrophosphate	63-84	interleukin 1 alpha	Homo sapiens	112-134
32699039-1	2020	OBJECTIVE: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1beta-dependent inflammation during gout and pseudo-gout flare, respectively.	Calcium Pyrophosphate	86-89	interleukin 1 alpha	Homo sapiens	112-134
32699039-8	2020	CONCLUSION: In conclusion, we demonstrated that GLUT1-mediated glucose uptake is instrumental during the inflammatory IL-1beta response induced by MSU and CPP crystals.	Uric Acid	147-150	interleukin 1 alpha	Homo sapiens	118-126
33313245-0	2020	MicroRNA-25-3p therapy for intervertebral disc degeneration by targeting the IL-1beta/ZIP8/MTF1 signaling pathway with a novel thermo-responsive vector.	microrna-25-3p	0-14	interleukin 1 alpha	Homo sapiens	77-85
33222465-7	2020	Similarly,4-Octyl Itaconate inhibited the secretion of inflammatory cytokines (TNF-alpha, IL-1beta, IL6, and IL-8) by MCs, which was induced by LPS, but SIRT4 knockdown decreases the inhibition of 4-Octyl Itaconate.	4-Octyl Itaconate	10-27	interleukin 1 alpha	Homo sapiens	90-98
33010623-10	2020	Additionally, this analogue exhibited higher potency than BBG at inhibiting the ATP-induced release of IL-1beta in vitro.	coomassie Brilliant Blue	58-61	interleukin 1 alpha	Homo sapiens	103-111
33313245-13	2020	MiRNA- 25-3p could inhibit the effects of IL-1beta and the expression of ECM degrading enzymes, and recover the expression of ECM protein.	mirna- 25-3p	0-12	interleukin 1 alpha	Homo sapiens	42-50
33313245-17	2020	Conclusions: The thermo-responsive vector delivering miRNA-25-3p could delay the progression of IDD by inhibiting IL-1beta-induced effects, and may be potential therapy for IDD in future.	mirna-25-3p	53-64	interleukin 1 alpha	Homo sapiens	114-122
32879146-2	2020	Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1beta)-induced MMPs production and its underlying mechanism were explored in SW1353 cells.	sinomenine	22-32	interleukin 1 alpha	Homo sapiens	61-69
32879146-2	2020	Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1beta)-induced MMPs production and its underlying mechanism were explored in SW1353 cells.	sinomenine	34-36	interleukin 1 alpha	Homo sapiens	61-69
32879146-5	2020	SN significantly suppressed mRNA and protein levels of MMPs in IL-1beta-induced SW1353 cells.	sinomenine	0-2	interleukin 1 alpha	Homo sapiens	63-71
33010623-10	2020	Additionally, this analogue exhibited higher potency than BBG at inhibiting the ATP-induced release of IL-1beta in vitro.	Adenosine Triphosphate	80-83	interleukin 1 alpha	Homo sapiens	103-111
33011537-3	2020	Compounds 7-10 and 12 showed inhibitory effects on NF-kappaB/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control.	Prednisone	238-248	interleukin 1 alpha	Homo sapiens	157-165
33152899-7	2020	In inactivated macrophages, u-QUE induced a proinflammatory state as observed by an increase in cellular proliferation; increased levels of oxidative molecules (nitric oxide and superoxide), protein levels, and gene overexpression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha); and decreased levels of IL-10, an anti-inflammatory cytokine.	u-que	28-33	interleukin 1 alpha	Homo sapiens	261-269
32979761-7	2020	In primary microglia, delta-tocotrienol downregulated IL-1beta production, but TNF-alpha and IL-6 were not affected.	tocotrienol, delta	22-39	interleukin 1 alpha	Homo sapiens	54-62
32506648-8	2020	Results showed that UA exposure inhibited cell viability and increased IL-1beta and IL-18 generation in a concentration dependent manner.	Uric Acid	20-22	interleukin 1 alpha	Homo sapiens	71-79
33215449-10	2020	RESULTS: IL-1beta could induce the decrease of viability, collagen II, aggrecan, but an increase of collagen X, TNF-alpha, IL-6, and MMP-13 in NP cells, as well as the upregulation of GRP78/PERK/caspase-12 and apoptosis level, which could be inhibited by parecoxib.	parecoxib	255-264	interleukin 1 alpha	Homo sapiens	9-17
32898511-10	2020	IL-1beta is increased by LPS and Poly I:C after 1 day, but not by TNFalpha.	Poly I	33-40	interleukin 1 alpha	Homo sapiens	0-8
32898511-10	2020	IL-1beta is increased by LPS and Poly I:C after 1 day, but not by TNFalpha.	Carbon	40-41	interleukin 1 alpha	Homo sapiens	0-8
32866784-8	2020	Additionally, IL-1beta/IL-18 secretion from ATP + LPS stimulated THP-1-derived macrophages was RalA-dependently suppressed by levornidazole, suggesting that RalA might have an inhibitory effect on NLRP3 inflammasome activation.	Adenosine Triphosphate	44-47	interleukin 1 alpha	Homo sapiens	14-22
32784000-6	2020	Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFkappaB1, TNFalpha, IL-6, IL-1beta and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH.	SMSF0006723	10-17	interleukin 1 alpha	Homo sapiens	136-144
32784000-6	2020	Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFkappaB1, TNFalpha, IL-6, IL-1beta and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH.	SMSF0006723	26-33	interleukin 1 alpha	Homo sapiens	136-144
32769069-7	2020	EGCG has been shown to prevent production and mRNA expression of TSLP, interleukin (IL)-1beta, IL-6, and IL-8 by RANKL without cytotoxicity.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	71-93
32866785-3	2020	Herein, we explored the effects and mechanisms of tyrosol on IDD progression in interleukin (IL)-1beta-stimulated human nucleus pulposus cells (HNPCs).	4-hydroxyphenylethanol	50-57	interleukin 1 alpha	Homo sapiens	80-102
32892075-7	2020	Additionally, DHA in vivo improved the clinical symptoms, reduced the production of pro-inflammatory factors IL-1beta, IL-6 and TNF-alpha, and suppressed the formation of NLRP3 inflammasome.	artenimol	14-17	interleukin 1 alpha	Homo sapiens	109-117
32866785-8	2020	Results showed that tyrosol attenuated IL-1beta-induced viability reduction, apoptosis, and caspase-3/7 activity in HNPCs.	4-hydroxyphenylethanol	20-27	interleukin 1 alpha	Homo sapiens	39-47
32866785-9	2020	The increase in the production of TNF-alpha, IL-6, NO, and PGE2 in IL-1beta-treated HNPCs was abolished by tyrosol treatment.	Dinoprostone	59-63	interleukin 1 alpha	Homo sapiens	67-75
32866785-9	2020	The increase in the production of TNF-alpha, IL-6, NO, and PGE2 in IL-1beta-treated HNPCs was abolished by tyrosol treatment.	4-hydroxyphenylethanol	107-114	interleukin 1 alpha	Homo sapiens	67-75
32866785-10	2020	Tyrosol treatment reversed IL-1beta-induced upregulation of MMP-3, MMP-9, and MMP-13, and downregulation of collagen II, SOX-9, and aggrecan in HNPCs.	4-hydroxyphenylethanol	0-7	interleukin 1 alpha	Homo sapiens	27-35
32866785-11	2020	Additionally, tyrosol treatment activated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in IL-1beta-stimulated HNPCs.	4-hydroxyphenylethanol	14-21	interleukin 1 alpha	Homo sapiens	98-106
33016027-11	2020	Furthermore, in these immune cells, IL-1 also elevates nitric oxide, and the release of inflammatory arachidonic acid products such as prostaglndins and thromboxane A2.	Thromboxane A2	153-167	interleukin 1 alpha	Homo sapiens	36-40
32866785-13	2020	Sirt1 knockdown attenuated the effects of tyrosol on IL-1beta-induced apoptosis, inflammation, and ECM remodeling in HNPCs.	4-hydroxyphenylethanol	42-49	interleukin 1 alpha	Homo sapiens	53-61
32866785-14	2020	In summary, upregulation of Sirt1 by tyrosol suppressed apoptosis and inflammation and regulated ECM remodeling in IL-1beta-stimulated HNPCs through activation of PI3K/Akt pathway.	4-hydroxyphenylethanol	37-44	interleukin 1 alpha	Homo sapiens	115-123
33182075-4	2020	The current study identified that LPS plus nigericin stimulation induced NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, which was detected by IL-1beta expression.	Nigericin	43-52	interleukin 1 alpha	Homo sapiens	165-173
33182075-7	2020	Our results suggest that FUNDC1 suppresses LPS plus nigericin-mediated IL-1beta production through its regulatory effect on mitophagy, which will greatly promote the understanding of mitophagy-related protein in the regulation of immune response.	Nigericin	52-61	interleukin 1 alpha	Homo sapiens	71-79
33139635-0	2020	Empagliflozin Inhibits Basal and IL-1beta-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells.	empagliflozin	0-13	interleukin 1 alpha	Homo sapiens	33-41
33139635-6	2020	The co-administration of Empa inhibited IL-1beta-mediated MCP-1/CCL2 (0.2-fold, each) and ET-1 (0.2-fold, each) mRNA expression as early as 1 h after ligand stimulation and for at least 24 h in both HPTC lines, respectively.	empagliflozin	25-29	interleukin 1 alpha	Homo sapiens	40-48
33139635-7	2020	This inhibitory effect of Empa on basal and IL-1beta-mediated MCP-1/CCL2 and ET-1 mRNA expression was corroborated at the protein level.	empagliflozin	26-30	interleukin 1 alpha	Homo sapiens	44-52
33016027-11	2020	Furthermore, in these immune cells, IL-1 also elevates nitric oxide, and the release of inflammatory arachidonic acid products such as prostaglndins and thromboxane A2.	Nitric Oxide	55-67	interleukin 1 alpha	Homo sapiens	36-40
33016027-11	2020	Furthermore, in these immune cells, IL-1 also elevates nitric oxide, and the release of inflammatory arachidonic acid products such as prostaglndins and thromboxane A2.	Arachidonic Acid	101-117	interleukin 1 alpha	Homo sapiens	36-40
33016027-11	2020	Furthermore, in these immune cells, IL-1 also elevates nitric oxide, and the release of inflammatory arachidonic acid products such as prostaglndins and thromboxane A2.	prostaglndins	135-148	interleukin 1 alpha	Homo sapiens	36-40
32162384-0	2020	Teneligliptin inhibits IL-1beta-induced degradation of extracellular matrix in human chondrocytes.	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	0-13	interleukin 1 alpha	Homo sapiens	23-31
32162384-5	2020	Treatment with teneligliptin significantly reduced IL-1beta-induced expression of tumor necrosis factor alpha, IL-6, and IL-8, generation of reactive oxygen species, increase in metalloproteinase 3 (MMP-3) and MMP-13, reduction of tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) and TIMP-2, release of lactate dehydrogenase, and activation of the mitogen-activated protein kinase p38 and nuclear factor kappaB intracellular signaling pathways, among other things.	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	15-28	interleukin 1 alpha	Homo sapiens	51-59
32162384-5	2020	Treatment with teneligliptin significantly reduced IL-1beta-induced expression of tumor necrosis factor alpha, IL-6, and IL-8, generation of reactive oxygen species, increase in metalloproteinase 3 (MMP-3) and MMP-13, reduction of tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) and TIMP-2, release of lactate dehydrogenase, and activation of the mitogen-activated protein kinase p38 and nuclear factor kappaB intracellular signaling pathways, among other things.	Reactive Oxygen Species	141-164	interleukin 1 alpha	Homo sapiens	51-59
32748974-0	2020	Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1beta.	Histamine	0-9	interleukin 1 alpha	Homo sapiens	239-247
32458591-7	2020	Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the reduction of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate	51-55	interleukin 1 alpha	Homo sapiens	181-189
32748974-5	2020	The expression of TF mRNA and surface protein of TF on HUVEC in response to histamine or VEGF were synergistically enhanced by the treatment with LPS, TNF-alpha, IL-33 or IL-1beta.	Histamine	76-85	interleukin 1 alpha	Homo sapiens	171-179
32901887-8	2020	In addition, an in vitro cell model of IDD was established by subjecting NP cells to 10 ng/ml interleukin (IL)-1beta for 24 h. Further experiments suggested that IL-1beta treatment induced a reduction in NP cell proliferation and an increase in cell apoptosis, which were prevented by the miR-25-3p mimic.	mir-25-3p	289-298	interleukin 1 alpha	Homo sapiens	162-170
33152658-6	2020	Treatment of HBCs with both LPS and ATP induced the rapid secretion of high levels of IL-1beta and at the same time, cell death associated with nuclear condensation and cellular swelling.	Adenosine Triphosphate	36-39	interleukin 1 alpha	Homo sapiens	86-94
33152658-7	2020	HBC treatment with both LPS and ATP induced caspase-1 activation, gasdermin D (GSDMD) cleavage, which mediates pyroptosis, and IL-1beta processing.	Adenosine Triphosphate	32-35	interleukin 1 alpha	Homo sapiens	127-135
33152658-9	2020	Together, our data indicate that LPS and ATP treatment stimulated NLRP3 inflammasome activation and pyroptosis in HBCs leading to the rapid release of IL-1beta.	Adenosine Triphosphate	41-44	interleukin 1 alpha	Homo sapiens	151-159
32518369-4	2020	Consequently, extracellular ADP activated the NLRP3 inflammasome through P2Y1 receptor-mediated calcium signaling, which led to the maturation and secretion of IL-1beta and further aggravation of experimental colitis.	Adenosine Diphosphate	28-31	interleukin 1 alpha	Homo sapiens	160-168
32518369-4	2020	Consequently, extracellular ADP activated the NLRP3 inflammasome through P2Y1 receptor-mediated calcium signaling, which led to the maturation and secretion of IL-1beta and further aggravation of experimental colitis.	Calcium	96-103	interleukin 1 alpha	Homo sapiens	160-168
32901887-9	2020	All the effects of miR-25-3p mimic on IL-1beta-treated NP cells were significantly reversed by Bim upregulation.	mir-25-3p	19-28	interleukin 1 alpha	Homo sapiens	38-46
32985128-7	2020	RESULTS: Children exposed to higher IL-1beta, IL-6, IL-8, and IL-10 concentrations had lower BMIz at birth but higher BMIz during childhood.	bmiz	93-97	interleukin 1 alpha	Homo sapiens	36-44
33276365-2	2020	Hsp70 and GYY4137 have been shown to significantly reduce LPS-induced production of inflammatory mediators by SH-SY5Y cells, including reactive oxygen species, nitric oxide, TNFalpha, IL-1beta, and IL-6.	GYY 4137	10-17	interleukin 1 alpha	Homo sapiens	184-192
32830258-8	2020	CDEC exposed to MCM from IgA1-stimulated THP-1 cells (THP-1-IgA-MCM) exhibited markedly increased expression of neutrophil-associated gelatinase (NGAL) and proinflammatory cytokinesinterleukin (IL)-1beta, tumour necrosis factor-alpha, IL-6 and IL-8 compared with MCM from non-IgA-stimulated THP-1 cells (THP-1-MCM).	CDEC	0-4	interleukin 1 alpha	Homo sapiens	172-203
32830258-10	2020	THP-1-IgA-MCM-derived exosomes induced similar increases in NGAL and cytokine expression while in cross-over experiments exosomes extracted from IL-1beta-exposed CDEC induced IL-1beta and IL-6 mRNA expression in both sets of macrophages.	CDEC	162-166	interleukin 1 alpha	Homo sapiens	145-153
32830258-10	2020	THP-1-IgA-MCM-derived exosomes induced similar increases in NGAL and cytokine expression while in cross-over experiments exosomes extracted from IL-1beta-exposed CDEC induced IL-1beta and IL-6 mRNA expression in both sets of macrophages.	CDEC	162-166	interleukin 1 alpha	Homo sapiens	175-183
32985128-7	2020	RESULTS: Children exposed to higher IL-1beta, IL-6, IL-8, and IL-10 concentrations had lower BMIz at birth but higher BMIz during childhood.	bmiz	118-122	interleukin 1 alpha	Homo sapiens	36-44
32985128-8	2020	Higher concentrations of IL-8 and IL-1beta were also associated with higher BMIz during infancy (B per log increase in IL-8 = 0.04; 95% CI: 0.02 to 0.07; B per log increase in IL-1beta = 0.03; 95% CI: 0.001 to 0.06).	bmiz	76-80	interleukin 1 alpha	Homo sapiens	34-42
32985128-8	2020	Higher concentrations of IL-8 and IL-1beta were also associated with higher BMIz during infancy (B per log increase in IL-8 = 0.04; 95% CI: 0.02 to 0.07; B per log increase in IL-1beta = 0.03; 95% CI: 0.001 to 0.06).	bmiz	76-80	interleukin 1 alpha	Homo sapiens	176-184
32306038-0	2020	Anti-IL1 treatment in colchicine-resistant paediatric FMF patients: real life data from the HELIOS registry.	Colchicine	22-32	interleukin 1 alpha	Homo sapiens	5-8
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	dihydromyricetin	82-98	interleukin 1 alpha	Homo sapiens	33-41
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	Chlorogenic Acid	100-116	interleukin 1 alpha	Homo sapiens	33-41
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	naringin	118-126	interleukin 1 alpha	Homo sapiens	33-41
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	maltotriose	152-165	interleukin 1 alpha	Homo sapiens	33-41
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	Curcumin	234-242	interleukin 1 alpha	Homo sapiens	33-41
32978075-4	2020	In EE- and/or ES-healthy, IL-1beta and/or TNFalpha secretion after stimulation with LPS or poly I:C was significantly higher in cells with ATG13 knockdown compared with those with siRNA control (P < 0.03), whereas no significant difference was observed in either EE/ES-endo or EE/ES-hydro.	Poly I	91-97	interleukin 1 alpha	Homo sapiens	26-34
32306038-2	2020	Anti-IL1 treatments are the first-line alternatives in colchicine-resistant/intolerant FMF patients.	Colchicine	55-65	interleukin 1 alpha	Homo sapiens	5-8
33135616-6	2021	RESULTS: B. animalis R101-8 inhibited LPS- and palmitic acid-induced protein expression of inflammatory cytokines IL-1beta, IL-6, TNF-alpha concomitant with decreases in chemerin, MCP-1, PEDF, and cellular triglycerides, and blocked NF-kB and AP-1 activation pathway through inhibition of p-IkappaBalpha, pc-Jun, and pc-Fos phosphorylation.	Palmitic Acid	47-60	interleukin 1 alpha	Homo sapiens	114-122
33193305-11	2020	As to C activation factors, C3a was the most produced and CFBa was induced by IL-1beta in synovial tissue.	cfba	58-62	interleukin 1 alpha	Homo sapiens	78-86
33126443-8	2020	Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-alpha, IL-1beta, IL-6, and NF-kappaB; and down-regulated HMBG1.	linalool	0-8	interleukin 1 alpha	Homo sapiens	131-139
33204262-11	2020	Meanwhile, BR treatment reduced the plasma levels of TNF-alpha, IL-1beta, and IL-6, and increased the level of IL-10(p < 0.05).	Bromine	11-13	interleukin 1 alpha	Homo sapiens	64-72
33114438-13	2020	As a result, we identified that Ac2-26 significantly decreased the expression of TNF-alpha/IFN-gamma-stimulated pro-inflammatory chemokines, including IL-1beta, IL-6, IL-8, MDC, TARC, and TNF-alpha, by inhibiting the activation of MAPK, NF-kappaB, and JAK/STAT pathway in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes.	annexin A1 peptide (2-26)	32-38	interleukin 1 alpha	Homo sapiens	151-159
33120999-11	2020	These results indicate that the PI3K/Akt/pGSK-3beta signaling pathway contributes to LDOC1-mediated inhibition of oral microbe-induced IL-1beta production, suggesting that LDOC1 may determine the pathogenic role of oral microbes in POH-associated OSCC.	pgsk-3beta	41-51	interleukin 1 alpha	Homo sapiens	135-143
33100111-8	2022	Compared with Model group, the levels of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, IL-6, myeloperoxidase (MPO), human endothelin (ET)-1 and p-P65 protein in formononetin treatment and omeprazole groups were significantly decreased (p < 0.05).	formononetin	174-186	interleukin 1 alpha	Homo sapiens	76-98
32989985-3	2020	Among the isolated constituents, compound 6 exhibited the most potent inhibitory effect (IC50: 1.3 muM) against nigericin-induced IL-1beta release in THP-1 cells.	Nigericin	112-121	interleukin 1 alpha	Homo sapiens	130-138
33497945-3	2020	The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1beta (IL-1beta), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level.	Cadmium	27-29	interleukin 1 alpha	Homo sapiens	116-124
33497945-4	2020	Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1beta and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels.	Cadmium	16-18	interleukin 1 alpha	Homo sapiens	74-82
33114240-9	2020	One of the latter compounds-7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate-at concentrations 0.5, 1.0 and 2.5 muM, significantly reduced IL-8, IL-1beta and CCL2 excretion by LPS-stimulated human neutrophils.	7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate	28-76	interleukin 1 alpha	Homo sapiens	145-153
33144845-7	2020	Hence, the cells stimulated with SiO2 responded with a distinctly different IL-18 : IL-1beta ratio.	Silicon Dioxide	33-37	interleukin 1 alpha	Homo sapiens	84-92
33145347-0	2020	Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in Response to IL-1beta.	Sirolimus	0-9	interleukin 1 alpha	Homo sapiens	159-167
33145347-8	2020	Further study revealed that rapamycin pretreatment promoted the migration of SMSCs and the expression of chondrogenesis-related markers in the presence of IL-1beta by inducing autophagy.	Sirolimus	28-37	interleukin 1 alpha	Homo sapiens	155-163
33145347-9	2020	3-Benzyl-5-((2-nitrophenoxy)methyl)-dihydrofuran-2(3H)-one (3BDO), a new activator of mTOR, inhibited autophagy and increased the expression of p-GSK3betaser9 and beta-catenin, simulating the effect of IL-1beta stimulation.	3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one	0-58	interleukin 1 alpha	Homo sapiens	202-210
33144845-8	2020	The difference in the IL-18 : IL-1beta ratio for SiO2 was constant over different doses.	Silicon Dioxide	49-53	interleukin 1 alpha	Homo sapiens	30-38
33144846-7	2020	Both BH and PH groups were consistent in presenting a positive correlation between concentrations of IL-6 and IL-1beta.	Bh	5-7	interleukin 1 alpha	Homo sapiens	110-118
33092247-8	2020	The findings showed that LPS/nigericin-treated cells expressing Rab5-WT indicated increased NALP3 expression and secretion of the IL-1beta as compared to Rab5-DN cells.	Nigericin	29-38	interleukin 1 alpha	Homo sapiens	130-138
32526304-6	2020	Additionally, HSP-W significantly induced NO and ROS production as well as the release of IL-1beta, IFN-gamma, TNF-alpha, and IL-6, and upregulated pinocytic and phagocytic capacities of THP-1 cells.	hsp-w	14-19	interleukin 1 alpha	Homo sapiens	90-98
32868342-8	2020	In addition, compared to SS2-infected STEC, PCV2/SS2 coinfection and pretreatment of STEC with NAC prior to SS2 infection both down-regulated the expression of inflammatory cytokines IL-6, TNF-alpha and IL-1beta.	Acetylcysteine	95-98	interleukin 1 alpha	Homo sapiens	203-211
33069077-5	2020	Furthermore, BBH showed asignificant anti-inflammatory effect through regulating activities of SOD, MPOandexpressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in colontissue.	alpha-hexachlorocyclohexane	13-16	interleukin 1 alpha	Homo sapiens	160-168
32798556-4	2020	Auranofin (AFN), a Txnrd1 inhibitor, decreases IL-1beta levels and increases Nrf2 activation in lipopolysaccharide (LPS) treated alveolar macrophages.	Auranofin	0-9	interleukin 1 alpha	Homo sapiens	47-55
32798556-4	2020	Auranofin (AFN), a Txnrd1 inhibitor, decreases IL-1beta levels and increases Nrf2 activation in lipopolysaccharide (LPS) treated alveolar macrophages.	Auranofin	11-14	interleukin 1 alpha	Homo sapiens	47-55
32783910-5	2020	Whereas upon switching to the CON diet for another 2 weeks, the deleterious effect of ZEA and DON on IL-1beta and Bifidobacterium population could not be recovered.	Zearalenone	86-89	interleukin 1 alpha	Homo sapiens	101-109
32783910-5	2020	Whereas upon switching to the CON diet for another 2 weeks, the deleterious effect of ZEA and DON on IL-1beta and Bifidobacterium population could not be recovered.	deoxynivalenol	94-97	interleukin 1 alpha	Homo sapiens	101-109
32783910-6	2020	Additionally, combined DON and ZEA negatively affected body weight gain and feed consumption of piglets, as well as shown synergistic effects on evoking pro-inflammatory cytokines contents (TNF-alpha, IL-1beta and IL-6) and perturbing the cecum microbiota profile (E. coli, Lactobacillus and Bifidobacterium).	Zearalenone	31-34	interleukin 1 alpha	Homo sapiens	201-209
33154749-9	2020	Finally, MSU-induced PMN-MDSCs produced higher levels of IL-1beta, which mediated gout inflammatory progression.	Uric Acid	9-12	interleukin 1 alpha	Homo sapiens	57-65
33066024-12	2020	Quininib significantly downregulated IL-2 and IL-6 in Mel285 cells (p < 0.05) but significantly upregulated IL-10, IL-1beta, IL-2 (p < 0.0001), IL-13, IL-8 (p < 0.001), IL-12p70 and IL-6 (p < 0.05) in OMM2.5 cells.	quininib	0-8	interleukin 1 alpha	Homo sapiens	115-123
33066025-10	2020	In this milieu, we demonstrated that (-)-catechin decreased the expression and secretion of proinflammatory cytokines, including interleukin (IL)-1beta and IL-6.	Catechin	41-49	interleukin 1 alpha	Homo sapiens	129-151
32861811-6	2020	RESULTS: IL-1beta concentration measured at admission was associated with all-cause mortality at 90 days (adjusted hazard ratio [adjHR], 1.47 per 1SD increase; 95% CI, 1.16 to 1.87; p<0.002).	CHEMBL569412	146-149	interleukin 1 alpha	Homo sapiens	9-17
32861811-10	2020	CONDENSED ABSTRACT: In this observational prospective cohort study that included 1398 patients with ST segment elevation myocardial infarction, IL-1beta concentration measured at admission was independently associated with all-cause mortality (adjusted hazard ratio [adjHR], 1.47 per 1SD increase; 95% CI, 1.16 to 1.87; p<0.002) and major cardiovascular event at 90 days and one year.	CHEMBL569412	284-287	interleukin 1 alpha	Homo sapiens	144-152
33038032-5	2021	The effect of rapamycin-treated NPC-derived exosomes on NPCs were assessed by co-culture with IL-1beta-stimulated NPCs.	Sirolimus	14-23	interleukin 1 alpha	Homo sapiens	94-102
33023630-9	2020	As previously reported, DEX or IgG alone significantly suppressed TNF-alpha-induced production of IL-6 and G-CSF and mRNA expression, but induction of those cytokines by IL-1 s (IL-1alpha and IL-1beta) was resistant to high-dose IgG.	Dexamethasone	24-27	interleukin 1 alpha	Homo sapiens	178-187
33023630-9	2020	As previously reported, DEX or IgG alone significantly suppressed TNF-alpha-induced production of IL-6 and G-CSF and mRNA expression, but induction of those cytokines by IL-1 s (IL-1alpha and IL-1beta) was resistant to high-dose IgG.	Dexamethasone	24-27	interleukin 1 alpha	Homo sapiens	192-200
33117168-8	2020	Further investigation indicated that atractylodin significantly increases PEA and OEA levels and dose-dependently inhibits LPS-induced nitrate, TNF-alpha, IL-1beta, and IL-6 pro-inflammatory cytokine release in BV-2 microglia.	atractylodin	37-49	interleukin 1 alpha	Homo sapiens	155-163
32706497-4	2020	Here, we report that simvastatin treatment blocked sodium nitroprusside (SNP)- and interleukin (IL)-1beta-induced COX-2 production.	Simvastatin	21-32	interleukin 1 alpha	Homo sapiens	83-105
32706497-5	2020	In addition, simvastatin attenuated SNP-induced NO production and IL-1beta-induced ROS generation.	Simvastatin	13-24	interleukin 1 alpha	Homo sapiens	66-74
32706497-6	2020	Treatment with simvastatin prevented SNP- and IL-1beta-induced nuclear factor (NF)-kappaB activity.	Simvastatin	15-26	interleukin 1 alpha	Homo sapiens	46-54
32706497-9	2020	L-NMMA treatment also abolished IL-1beta-mediated COX-2 expression and NF-kappaB activation, whereas SNP and simvastatin-mediated COX-2 expression was not altered compared with the levels in the SNP and simvastatin-treated cells.	N(G)-monomethylarginine acetate	0-6	interleukin 1 alpha	Homo sapiens	32-40
32706497-10	2020	Our findings suggested that simvastatin blocks COX-2 expression by inhibiting SNP-induced NO production and IL-1beta-induced ROS generation by blocking the NF-kappaB pathway.	Simvastatin	28-39	interleukin 1 alpha	Homo sapiens	108-116
32534297-9	2020	Anti-inflammatory IL-1RA concentration was negatively related with Pb, Cd, Hg and As, while pro-inflammatory IL-1beta and IL-6 were positively correlated with Pb.	Lead	159-161	interleukin 1 alpha	Homo sapiens	109-117
32755466-10	2020	IL-1beta or IL-6 in the absence of hMSCs prolonged action potential duration but only IL-6 increased Ca2+ alternans and promoted spontaneous calcium release activity in human cardiac myocytes derived from induced pluripotent stem cells, replicating the effects of failing hMSCs.	Calcium	141-148	interleukin 1 alpha	Homo sapiens	0-8
33155234-0	2020	Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6.	Naloxone	31-39	interleukin 1 alpha	Homo sapiens	131-135
33155234-0	2020	Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6.	Acyclovir	54-63	interleukin 1 alpha	Homo sapiens	131-135
33155234-13	2020	CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion.	Naloxone	66-74	interleukin 1 alpha	Homo sapiens	166-170
33155234-13	2020	CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion.	Ganciclovir	89-100	interleukin 1 alpha	Homo sapiens	166-170
33155234-13	2020	CONCLUSIONS: In the treatment of children, viral encephalitis has naloxone combined with ganciclovir had a more significant effect on the decrease of levels of serum IL-1 and IL-6; naloxone combined with acyclovir in the treatment of children viral encephalitis had better effects, lower adverse reactions and lower prevalence of sequelae compared with sole medication, which is worth clinical promotion.	Acyclovir	204-213	interleukin 1 alpha	Homo sapiens	166-170
32851734-4	2020	LPA also induced expression of interleukin-1beta (IL-1beta) mRNA but no significant increase in IL-1beta protein was detected.	lysophosphatidic acid	0-3	interleukin 1 alpha	Homo sapiens	50-58
32738593-0	2020	Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1beta and TNF-alpha.	sesquiterpene lactone	0-21	interleukin 1 alpha	Homo sapiens	150-158
32738593-0	2020	Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1beta and TNF-alpha.	zaluzanin-D	22-33	interleukin 1 alpha	Homo sapiens	150-158
32678677-11	2020	Compared with the baseline, CGM-GLN produced 54.52%, 59.08%, and 22.03% reduction in IL-1beta, IL-6, and sVCAM levels, respectively.	cgm-gln	28-35	interleukin 1 alpha	Homo sapiens	85-93
32755990-11	2020	DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF.	Dihydrotestosterone	0-3	interleukin 1 alpha	Homo sapiens	138-141
32562275-0	2020	Cannabinoid type-2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL-1beta stimulated primary human periodontal ligament fibroblasts.	Cannabinoids	0-11	interleukin 1 alpha	Homo sapiens	109-117
32562275-0	2020	Cannabinoid type-2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL-1beta stimulated primary human periodontal ligament fibroblasts.	anandamide	58-68	interleukin 1 alpha	Homo sapiens	109-117
33000581-10	2020	The mechanism could be that it reduced ROS produce and inhibited NLRP3 inflammasome activation so that mainly lower the downstream inflammatory cytokines IL-1beta and IL-18.	Reactive Oxygen Species	39-42	interleukin 1 alpha	Homo sapiens	154-162
32945495-10	2020	To conclude, NAC had anti-inflammatory effects on LPS-stimulated BMSCs, which was closely associated with the TXNIP/NLRP3/IL-1beta signaling pathway.	Acetylcysteine	13-16	interleukin 1 alpha	Homo sapiens	122-130
32645635-5	2020	Our observations suggest that blocking IL-1 is a safe and an effective alternative for colchicine resistant FMF and probably also for associated MS.	Colchicine	87-97	interleukin 1 alpha	Homo sapiens	39-43
33110480-5	2020	RESULTS: High IL-6, IL-1beta and TNFRI levels were found in PMC and NC exposed to talc.	Talc	82-86	interleukin 1 alpha	Homo sapiens	20-28
33117348-13	2020	Pathway functionality was confirmed by cholesterol crystal activation of IL-1beta in cultured decidual explants.	Cholesterol	39-50	interleukin 1 alpha	Homo sapiens	73-81
33117342-7	2020	Leonurine treatment had a direct recovery effect on the impaired balance and reduced the expression of TAZ and led to normalization of IL-17, IL-1beta, and TNF-alpha and IL-10.	leonurine	0-9	interleukin 1 alpha	Homo sapiens	142-150
33117381-1	2020	The pro-inflammatory cytokine interleukin 1beta (IL-1beta) induces the synthesis of prostaglandin E2 by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA).	Dinoprostone	84-100	interleukin 1 alpha	Homo sapiens	49-57
33117381-4	2020	We observed an increase in the mRNA and protein levels of COX-2 and prostaglandin E2 release in cells treated with IL-1beta.	Dinoprostone	68-84	interleukin 1 alpha	Homo sapiens	115-123
33023630-8	2020	RESULTS: DEX, but not IgG, significantly inhibited apoptosis caused by inflammatory stimuli, resulting in effective reduction of HMGB1 and IL-1alpha protein release by HCAECs.	Dexamethasone	9-12	interleukin 1 alpha	Homo sapiens	139-148
33083489-0	2020	Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1beta, and TNF-alpha in Chronic Periodontitis Patients.	Curcumin	12-20	interleukin 1 alpha	Homo sapiens	53-61
33083489-2	2020	The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1beta and TNF-alpha) in chronic periodontitis patients.	Curcumin	47-55	interleukin 1 alpha	Homo sapiens	155-163
32598947-7	2020	The ability of the colchicine analogues with the predicted highest affinity for betaVI-tubulin to dampen neutrophil responses to MSU was determined with in vitro assays that measure MSU-induced production of ROS, release of IL-1 and IL-8, and the increase in the concentration of cytoplasmic calcium.	Colchicine	19-29	interleukin 1 alpha	Homo sapiens	224-228
32564679-4	2020	We found that viability and inflammatory factor release, including interleukin-1beta (IL-1beta) and IL-6, were negatively related to miR-375-3p expression in HaCaT cells.	mir-375-3p	133-143	interleukin 1 alpha	Homo sapiens	86-94
32841551-12	2020	Moreover, the results showed that the neuroinflammation factors (TNF-alpha, IL-6, IL-1beta) in DCA treatment groups increased significantly compared with the control pups.	Dichloroacetic Acid	95-98	interleukin 1 alpha	Homo sapiens	82-90
31993881-5	2020	In this study, we observed that Taxol treatment caused pyroptotic cell death, along with activation of Caspase-1 and maturation of IL-1beta, as well as cleavage of GSDMD, which is the canonical pyroptosis executor.	Paclitaxel	32-37	interleukin 1 alpha	Homo sapiens	131-139
32420661-8	2020	In addition, mangiferin markedly mediated protein levels of PER1 and NLRP3 in LPS-induced NSCLC cells and reduced the secretion of IL-1beta.	mangiferin	13-23	interleukin 1 alpha	Homo sapiens	131-139
32735798-13	2020	All agonists induced the secretion of IL-1ss, IL-8, and TNFalpha in microglia cells while in real-time PCR, LPS and Pam induced the expression of IL-6, IL-1ss and iNOS.	pam	116-119	interleukin 1 alpha	Homo sapiens	38-42
32735798-16	2020	Additionally a slight induction of IL-1ss was found in microglia treated with supernatant of RPE cells treated with Pam.	pam	116-119	interleukin 1 alpha	Homo sapiens	35-39
32877711-7	2020	At the tested concentration of 100 muM, the new conjugated chalcone-stilbene 5, the dihydrochalcone, 8 and the lignanamide, 13 were substantially more potent than the standard drug, ibuprofen, inhibiting the release of all the cytokines, IL-1beta, IL-2, GM-CSF and TNF-alpha from 0.06-58.04% compared to LPS control.	Chalcone	59-67	interleukin 1 alpha	Homo sapiens	238-246
32877711-7	2020	At the tested concentration of 100 muM, the new conjugated chalcone-stilbene 5, the dihydrochalcone, 8 and the lignanamide, 13 were substantially more potent than the standard drug, ibuprofen, inhibiting the release of all the cytokines, IL-1beta, IL-2, GM-CSF and TNF-alpha from 0.06-58.04% compared to LPS control.	Stilbenes	68-76	interleukin 1 alpha	Homo sapiens	238-246
32877711-7	2020	At the tested concentration of 100 muM, the new conjugated chalcone-stilbene 5, the dihydrochalcone, 8 and the lignanamide, 13 were substantially more potent than the standard drug, ibuprofen, inhibiting the release of all the cytokines, IL-1beta, IL-2, GM-CSF and TNF-alpha from 0.06-58.04% compared to LPS control.	dihydrochalcone	84-99	interleukin 1 alpha	Homo sapiens	238-246
32877711-7	2020	At the tested concentration of 100 muM, the new conjugated chalcone-stilbene 5, the dihydrochalcone, 8 and the lignanamide, 13 were substantially more potent than the standard drug, ibuprofen, inhibiting the release of all the cytokines, IL-1beta, IL-2, GM-CSF and TNF-alpha from 0.06-58.04% compared to LPS control.	lignanamide	111-122	interleukin 1 alpha	Homo sapiens	238-246
32441136-12	2020	UTI attenuated the TNF-alpha and IL-1beta release induced by isoflurane.	Isoflurane	61-71	interleukin 1 alpha	Homo sapiens	33-41
33380704-6	2020	Results: : Both candesartan and atorvastatin treated groups showed significant decrease in serum levels IL-1beta and TNF-alpha, acute-phase reactants (CRP and ESR), number of swollen joint and patient global assessment.	candesartan	16-27	interleukin 1 alpha	Homo sapiens	104-112
33380704-6	2020	Results: : Both candesartan and atorvastatin treated groups showed significant decrease in serum levels IL-1beta and TNF-alpha, acute-phase reactants (CRP and ESR), number of swollen joint and patient global assessment.	Atorvastatin	32-44	interleukin 1 alpha	Homo sapiens	104-112
32657437-13	2020	In a UV-challenge clinical, pretreatment with 5% Nam reduced erythema and skin surface IL-1alphaRA/IL-1alpha inflammatory biomarkers that were induced by SSR.	SSR128129E	154-157	interleukin 1 alpha	Homo sapiens	87-96
32678677-12	2020	Whereas CHN-GLN group of subjects expressed only 23.17%, 21.38%, and 6.82% reduction in IL-1beta, IL-6, and sVCAM levels, respectively.	Glutamine	12-15	interleukin 1 alpha	Homo sapiens	88-96
32663196-3	2020	Here, we found that expression of TET genes, methylation erasers, was downregulated in inflamed mouse and human tissues, and that this was caused by upregulation of TET-targeting miRNAs such as MIR20A, MIR26B, and MIR29C, likely due to activation of NF-kappaB signaling downstream of IL-1beta and TNF-alpha.	tetramethylenedisulfotetramine	34-37	interleukin 1 alpha	Homo sapiens	284-292
32663196-3	2020	Here, we found that expression of TET genes, methylation erasers, was downregulated in inflamed mouse and human tissues, and that this was caused by upregulation of TET-targeting miRNAs such as MIR20A, MIR26B, and MIR29C, likely due to activation of NF-kappaB signaling downstream of IL-1beta and TNF-alpha.	tetramethylenedisulfotetramine	165-168	interleukin 1 alpha	Homo sapiens	284-292
33456597-9	2020	Addition of synbiotic to allopurinol leads to a blood uric acid lowering (18.7% vs. 13.3%, p <0.01), CRP reduction (75% vs. 26.3%, p <0.01) as well as decrease of cytokines level: IL-1beta, IL-6, IL-8, IL-10 and TNFalpha (all p <0.001).	Allopurinol	25-36	interleukin 1 alpha	Homo sapiens	180-188
32100289-9	2020	TREM-1, PGLYRP1 and IL-1beta could not distinguish between CF and SH but showed positive correlation with GI, PI and BOP in both groups.	bop	117-120	interleukin 1 alpha	Homo sapiens	20-28
32998623-10	2021	The expressions of IL-1beta and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0.	CHEMBL3740941	136-138	interleukin 1 alpha	Homo sapiens	19-27
32504923-8	2020	NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-alpha in human clinical trials.	Acetylcysteine	0-3	interleukin 1 alpha	Homo sapiens	67-74
32505910-5	2020	IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta.	Leucine	87-94	interleukin 1 alpha	Homo sapiens	0-8
32627113-7	2020	The BzATP and ATP induced calcium overload, mitochondria injury, interleukin-1beta (IL-1beta) secretion, and cytotoxicity can be inhibited by TRPA1 antagonists.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	4-9	interleukin 1 alpha	Homo sapiens	84-92
32627113-7	2020	The BzATP and ATP induced calcium overload, mitochondria injury, interleukin-1beta (IL-1beta) secretion, and cytotoxicity can be inhibited by TRPA1 antagonists.	Adenosine Triphosphate	6-9	interleukin 1 alpha	Homo sapiens	84-92
32794617-4	2020	Uric acid sodium salt induces caspase-1 activation, cell death, and the expression of proinflammatory cytokines, including IL-1alpha, IL-6, and IL-8, in the human keratinocyte HOK-16B cell line.	Uric acid sodium salt	0-21	interleukin 1 alpha	Homo sapiens	123-132
32937100-0	2020	Histone Deacetylase 3 Couples Mitochondria to Drive IL-1beta-Dependent Inflammation by Configuring Fatty Acid Oxidation.	Fatty Acids	99-109	interleukin 1 alpha	Homo sapiens	52-60
32945495-0	2020	N-acetyl cysteine inhibits the lipopolysaccharide-induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL-1beta signaling pathway.	Acetylcysteine	0-17	interleukin 1 alpha	Homo sapiens	149-157
33002030-10	2020	Furthermore, IL-1beta was decreased at the site of MSU crystal injection, TLR2 expression on peripheral neutrophils was downregulated, and expression of CXCL1 in serum was suppressed with low and moderate-intensity exercise.	Uric Acid	51-54	interleukin 1 alpha	Homo sapiens	13-21
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	interleukin 1 alpha	Homo sapiens	111-115
32390268-12	2020	PRBC-SN augmented LPS-driven IL-1beta and caspase-1 production.	prbc-sn	0-7	interleukin 1 alpha	Homo sapiens	29-37
32739154-5	2020	For the peroxynitrite-modified proteins, we found a strongly enhanced activation of TLR4 and the pro-inflammatory transcription factor NF-kappaB in stable reporter cell lines as well as increased mRNA expression and secretion of the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-8 in human monocytes (THP-1).	Peroxynitrous Acid	8-21	interleukin 1 alpha	Homo sapiens	271-279
32533192-10	2020	CONCLUSION: Anti-IL-1 therapies (i.e. anakinra and canakinumab) appear to be effective and safe options in the treatment of overall FMF, including patients with colchicine resistance and FMF-related amyloidosis.	Colchicine	161-171	interleukin 1 alpha	Homo sapiens	17-21
32645342-6	2020	Further, IL-1alpha and MIF levels in EpiDerm, LabCyte, and EpiSkin models stimulated with sodium dodecyl sulfate (SDS) were inversely correlated with cell viability, and were detected even at low SDS concentrations without cell toxicity.	Sodium Dodecyl Sulfate	90-112	interleukin 1 alpha	Homo sapiens	9-18
32645342-6	2020	Further, IL-1alpha and MIF levels in EpiDerm, LabCyte, and EpiSkin models stimulated with sodium dodecyl sulfate (SDS) were inversely correlated with cell viability, and were detected even at low SDS concentrations without cell toxicity.	Sodium Dodecyl Sulfate	114-117	interleukin 1 alpha	Homo sapiens	9-18
32645342-6	2020	Further, IL-1alpha and MIF levels in EpiDerm, LabCyte, and EpiSkin models stimulated with sodium dodecyl sulfate (SDS) were inversely correlated with cell viability, and were detected even at low SDS concentrations without cell toxicity.	Sodium Dodecyl Sulfate	196-199	interleukin 1 alpha	Homo sapiens	9-18
32998161-8	2020	Along with 48 hours PEMF stimulation, TCs were treated with IL-1beta and A2AAR agonist CGS-21680.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	38-41	interleukin 1 alpha	Homo sapiens	60-68
32998161-11	2020	In presence of IL-1beta, TCs showed an upregulation of ADORA2A, SCX and COL3A1 expression and an increase of IL-6, IL-8, PGE2 and VEGF secretion.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	25-28	interleukin 1 alpha	Homo sapiens	15-23
32998161-13	2020	These findings demonstrated that A2AARs have a role in the promotion of the TC anabolic/reparative response to PEMFs and to IL-1beta.	Technetium	76-78	interleukin 1 alpha	Homo sapiens	124-132
32998161-11	2020	In presence of IL-1beta, TCs showed an upregulation of ADORA2A, SCX and COL3A1 expression and an increase of IL-6, IL-8, PGE2 and VEGF secretion.	Dinoprostone	121-125	interleukin 1 alpha	Homo sapiens	15-23
32998161-12	2020	After PEMF and IL-1beta exposure, IL-33 was upregulated, whereas IL-6, PGE2 and ADORA2A were downregulated.	Dinoprostone	71-75	interleukin 1 alpha	Homo sapiens	15-23
32794529-8	2020	Moreover, as compared to the control group, sows and newborn piglets in the Na2SeO3 and HMSeBA groups had a lower serum interleukin-6 (p < 0.05) concentration, and placentas in the HMSeBA group had lower IL-1beta, IL-6 and IL-8 gene expression (p < 0.05).	na2seo3	76-83	interleukin 1 alpha	Homo sapiens	204-212
33062145-0	2020	Oleanolic Acid Decreases IL-1beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-kappaB Axis in Osteoarthritis.	Oleanolic Acid	0-14	interleukin 1 alpha	Homo sapiens	25-33
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	Oleanolic Acid	52-66	interleukin 1 alpha	Homo sapiens	105-113
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	ola	69-72	interleukin 1 alpha	Homo sapiens	105-113
33061298-11	2020	Results: The presence of Linagliptin significantly reduced ox-LDL-induced cytokine production (IL-1beta and IL-6) and ROS production.	Linagliptin	25-36	interleukin 1 alpha	Homo sapiens	95-103
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	ssnb	14-18	interleukin 1 alpha	Homo sapiens	136-144
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	alpha-naphthyl butyrate	23-26	interleukin 1 alpha	Homo sapiens	136-144
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	Dexmedetomidine	32-35	interleukin 1 alpha	Homo sapiens	136-144
32753318-4	2020	Therefore, this study aims to show that DHA significantly inhibited the proliferation of VSMCs and that expression of the inflammatory cytokines IL-1beta and TNF-alpha was induced by HG in a dose-dependent manner.	Mercury	183-185	interleukin 1 alpha	Homo sapiens	145-153
32856912-3	2020	In this study, we analyzed the initial dissolution of CO2 into an IL 1-butyl-3-methylimidazolium bis- (trifluoromethylsulfonyl)imide ([C4min] [NTf2] ) by measuring its solubility using a combination of a molecular beam and a flowing liquid jet sheet beam (FJSB), and the King and Wells method (KW method).	Carbon Dioxide	54-57	interleukin 1 alpha	Homo sapiens	66-70
32856912-3	2020	In this study, we analyzed the initial dissolution of CO2 into an IL 1-butyl-3-methylimidazolium bis- (trifluoromethylsulfonyl)imide ([C4min] [NTf2] ) by measuring its solubility using a combination of a molecular beam and a flowing liquid jet sheet beam (FJSB), and the King and Wells method (KW method).	triflic imide	97-132	interleukin 1 alpha	Homo sapiens	66-70
32967723-10	2020	We also found that peptides 7118TGAKIKLVGT7127 derived from MUC19 and 508AAAAGPANVH517 derived from SIX5 reduced the expression levels of TNF-alpha, IL-1beta, and IL-6 in H2O2-treated human lung epithelial cells.	Hydrogen Peroxide	171-175	interleukin 1 alpha	Homo sapiens	149-157
32967164-0	2020	Downregulation of Inflammatory Cytokine Release from IL-1beta and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor.	ST2825	102-108	interleukin 1 alpha	Homo sapiens	53-61
32967076-5	2020	Patients treated with metformin showed decreased levels of all analyzed serum pro-inflammatory markers (TNFalpha, IL6, IL1beta and MCP1) and a downwards trend in IL18 levels associated with a lower production of oxidative stress markers in leukocytes (mitochondrial ROS and myeloperoxidase (MPO)).	Metformin	22-31	interleukin 1 alpha	Homo sapiens	119-126
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	interleukin 1 alpha	Homo sapiens	142-150
32950972-11	2020	In IL-1beta-treated PHCs, CI994 promoted AGGRECAN expression and suppressed MMP-13 expression, abolishing the effect of IL-1beta on PHCs.	tacedinaline	26-31	interleukin 1 alpha	Homo sapiens	3-11
32950972-11	2020	In IL-1beta-treated PHCs, CI994 promoted AGGRECAN expression and suppressed MMP-13 expression, abolishing the effect of IL-1beta on PHCs.	tacedinaline	26-31	interleukin 1 alpha	Homo sapiens	120-128
32962126-1	2020	The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin-1 beta (IL-1beta).	piperine	14-22	interleukin 1 alpha	Homo sapiens	225-233
32961826-10	2020	In cancer cells, TAT-FADD suppresses the canonical NLRP3 inflammasome priming and restricts the processing and secretion of proinflammatory IL-1beta.	tat-fadd	17-25	interleukin 1 alpha	Homo sapiens	140-148
32962126-2	2020	However, investigation into the molecular interactions between IL-1beta and piperine is not reported in the literature.	piperine	76-84	interleukin 1 alpha	Homo sapiens	63-71
32962126-3	2020	Here, we present for the first time the characterisation of the complex formed by IL-1beta and piperine through experimental and computational molecular biophysical analyses.	piperine	95-103	interleukin 1 alpha	Homo sapiens	82-90
32962126-4	2020	Fluorescence spectroscopy unveiled the presence of one binding site for piperine with an affinity constant of 14.3 x 104 M-1 at 298 K. The thermodynamic analysis indicated that the interaction with IL-1beta was spontaneous ( G = -25 kJ/mol) and, when split into enthalpic and entropic contributions, the latter was more significant.	piperine	72-80	interleukin 1 alpha	Homo sapiens	198-206
32948212-18	2020	From a mechanistic perspective, RSV inhibited the degradation of IkappaB-alpha as well as the activation of nuclear factor-kappa B (NF-kappaB) induced by IL-1beta.	Resveratrol	32-35	interleukin 1 alpha	Homo sapiens	154-162
32948212-3	2020	The purpose of the experiment was to evaluate the protective role of RSV against the human OA chondrocyte injury induced by interleukin-1beta (IL-1beta).	Resveratrol	69-72	interleukin 1 alpha	Homo sapiens	143-151
32948212-9	2020	The mechanism of RSV for protecting IL-1beta induced chondrocytes injury was further measured through immunofluorescence and WB assays.	Resveratrol	17-20	interleukin 1 alpha	Homo sapiens	36-44
32961947-10	2020	Using co-cultures of C. acnes and THP-1 cells, beta-ionone, a compound of the ESF, reduced the production of IL-1beta and IL-8 up to 40% and 18%, respectively.	beta-ionone	47-58	interleukin 1 alpha	Homo sapiens	109-117
32948212-15	2020	RSV (24 muM) also markedly depressed the levels of PGE2 and NO induced by IL-1beta by 25% and 29% respectively (P < 0.05).	Resveratrol	0-3	interleukin 1 alpha	Homo sapiens	74-82
32948212-15	2020	RSV (24 muM) also markedly depressed the levels of PGE2 and NO induced by IL-1beta by 25% and 29% respectively (P < 0.05).	Dinoprostone	51-55	interleukin 1 alpha	Homo sapiens	74-82
32948212-16	2020	Our experiment pointed out that RSV could dramatically inhibit the inflammatory response induced by IL-1beta, including the MMP-13, MMP-3, and MMP-1 in human OA chondrocytes by 50%, 35%, and 33% respectively.	Resveratrol	32-35	interleukin 1 alpha	Homo sapiens	100-108
32961947-11	2020	beta-ionone also reduced epidermal microabscess, neutrophilic infiltration and IL-1beta expression in mouse ear.	beta-ionone	0-11	interleukin 1 alpha	Homo sapiens	79-87
32497592-8	2020	Furthermore, FLX treatment, regardless of CORT treatment, increased maternal hippocampal IL-1beta, plasma CXCL1, and decreased maternal plasma tryptophan, 4"-pyridoxic acid, and pyridoxal concentrations.	Fluoxetine	13-16	interleukin 1 alpha	Homo sapiens	89-97
32634441-8	2020	We found that COB-187 significantly reduced, at the protein and mRNA levels, cytokines induced by LPS (e.g. IL-6, TNF-alpha, IL-1beta, CXCL10, and IFN-beta).	cob-187	14-21	interleukin 1 alpha	Homo sapiens	125-133
32645333-5	2020	Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA.	salvianolic acid B	5-8	interleukin 1 alpha	Homo sapiens	134-142
31954830-5	2020	Similarly, the levels of the NLRP1 inflammasome proteins, cleaved caspase-1, mature IL-1beta and IL-18 were elevated in SY-5Y cells exposed to oxygen-glucose deprivation (OGD).	Oxygen	143-157	interleukin 1 alpha	Homo sapiens	84-92
32924970-8	2020	Furthermore, DHC decreased the expression of pro-inflammatory cytokines induced by TNF-alpha, such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	dehydrocostus lactone	13-16	interleukin 1 alpha	Homo sapiens	121-129
32963505-7	2020	Glycyrrhizin significantly prevented TNF-alpha-induced expression of HMGB1 (691.5 +- 136.4 vs 142.8 +- 57.3 pg/mL), IL-6 (388.1 +- 85.2 vs 189.4 +- 61.2 pg/mL) and IL-1beta (176.3 +- 47.2 vs 53.9 +- 25.7 pg/mL) in hPDLSC.	Glycyrrhizic Acid	0-12	interleukin 1 alpha	Homo sapiens	164-172
32983576-8	2020	Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1beta, and IL-1beta levels were pronouncedly elevated in cells exposed to H2O2.	Hydrogen Peroxide	129-133	interleukin 1 alpha	Homo sapiens	52-60
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Fatty Acids	12-22	interleukin 1 alpha	Homo sapiens	222-235
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Fatty Acids	12-22	interleukin 1 alpha	Homo sapiens	237-241
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Prostaglandins	98-111	interleukin 1 alpha	Homo sapiens	222-235
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Prostaglandins	98-111	interleukin 1 alpha	Homo sapiens	237-241
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Dinoprostone	112-116	interleukin 1 alpha	Homo sapiens	222-235
32927704-8	2020	The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha).	Dinoprostone	112-116	interleukin 1 alpha	Homo sapiens	237-241
33013867-7	2020	The findings of this study verified that rMgPa could induce the secretion of eCypA in SV-HUC-1 cells and thus promote the protein and mRNA expression of IL-1beta, IL-6, TNF-alpha and MMP-9 via CypA-CD147 interaction and thus activating ERK-NF-kappaB pathway, which is beneficial to elucidate the pathogenesis and possible pathogenic mechanism of M. genitalium to host cells.	rmgpa	41-46	interleukin 1 alpha	Homo sapiens	153-161
33029092-13	2020	Dexmedetomidine also attenuated the LPS-induced mRNA expression of TNF-alpha and IL-1beta.	Dexmedetomidine	0-15	interleukin 1 alpha	Homo sapiens	81-89
33489861-9	2021	PGH or PHMG-P showed cytotoxic effects, IL-1beta secretion, and ROS production in a dose-dependent manner in human cell lines.	GH2 protein, human	0-3	interleukin 1 alpha	Homo sapiens	40-48
33489861-9	2021	PGH or PHMG-P showed cytotoxic effects, IL-1beta secretion, and ROS production in a dose-dependent manner in human cell lines.	polyhexamethyleneguanidine	7-13	interleukin 1 alpha	Homo sapiens	40-48
32899791-5	2020	However, the resistance mechanism was independent of MGMT, and the cells that acquired TMZ resistance showed increased NLRP1 expression, NLRP inflammasome activation, IL-1beta secretion, and NF-kappaB activity, which contributed to the acquired resistance to TMZ.	Temozolomide	87-90	interleukin 1 alpha	Homo sapiens	167-175
32899830-10	2020	It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions.	Adenine	21-24	interleukin 1 alpha	Homo sapiens	152-160
32899830-10	2020	It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions.	Anthocyanins	48-60	interleukin 1 alpha	Homo sapiens	152-160
32750036-8	2020	Targeting aberrant glucose metabolism with shikonin, a pyruvate kinase M2 inhibitor, dampened NLRP3-mediated inflammation (caspase-1 (p<0.05), IL1beta (p<0.01)) and improved healing in vivo.	shikonin	43-51	interleukin 1 alpha	Homo sapiens	143-150
32768942-5	2020	We found that mJPYZ decreased the activity of PI3-kinase gamma (PI3Kgamma) in TAMs, reduced the anti-inflammatory factor IL-10 and increased the expression of pro-inflammatory cytokines, such as TNF-alpha and IL-1beta, which ultimately promoted the conversion of TAMs from M2 to M1.	mjpyz	14-19	interleukin 1 alpha	Homo sapiens	209-217
32582975-4	2020	It was observed that IL-1beta significantly attenuated the proliferation and differentiation of OPCs, as evidenced by a decrease in bromodeoxyuridine incorporation and reduced percentage of myelin basic protein-positive cells among the total number of oligodendrocyte transcription factor 2-positive cells.	Bromodeoxyuridine	132-149	interleukin 1 alpha	Homo sapiens	21-29
32582975-6	2020	Treatment with the beta-catenin inhibitor XAV939, Gli1 siRNA, or miR-202-3p mimic transfection, attenuated the IL-1beta-induced suppression of OPC proliferation and differentiation.	XAV939	42-48	interleukin 1 alpha	Homo sapiens	111-119
32582975-6	2020	Treatment with the beta-catenin inhibitor XAV939, Gli1 siRNA, or miR-202-3p mimic transfection, attenuated the IL-1beta-induced suppression of OPC proliferation and differentiation.	mir-202-3p	65-75	interleukin 1 alpha	Homo sapiens	111-119
32584515-7	2020	In addition, periplocin decreased the TNF-alpha-induced mRNA and protein expression levels of interleukin (IL)-1beta and IL-6 in RA-FLSs in a dose-dependent way.	periplocin	13-23	interleukin 1 alpha	Homo sapiens	94-116
32507974-7	2020	RESULTS: LPS-induced inflammation in the presence of ATP activates NLRP3 that subsequently increases pancreatic cancer cell proliferation by increasing caspase-1 activity leading to overall production of IL-1beta.	Adenosine Triphosphate	53-56	interleukin 1 alpha	Homo sapiens	204-212
32716363-4	2020	We found that NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1beta production were reduced in beta-glucan-reprogrammed macrophages.	beta-Glucans	114-125	interleukin 1 alpha	Homo sapiens	78-86
32716363-6	2020	Importantly, beta-glucan-induced memory in macrophages resulted in a remarkable attenuation of IL-1beta secretion and caspase-1 activation in patients with an NLRP3-associated autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS).	beta-Glucans	13-24	interleukin 1 alpha	Homo sapiens	95-103
32716363-7	2020	Our findings demonstrate that beta-glucan-induced innate immune memory represses IL-1beta-mediated inflammation and support its potential clinical use in NLRP3-driven diseases.	beta-Glucans	30-41	interleukin 1 alpha	Homo sapiens	81-89
32614483-0	2020	Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL-1beta and TNF-alpha in LNCaP; prostate cancer.	Reactive Oxygen Species	26-29	interleukin 1 alpha	Homo sapiens	102-110
32614483-0	2020	Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL-1beta and TNF-alpha in LNCaP; prostate cancer.	Arbutin	33-40	interleukin 1 alpha	Homo sapiens	102-110
32614483-5	2020	In addition, 1,000 microM of arbutin successfully decreased expressions of IL-1beta and TNF-alpha genes (p < .05).	Arbutin	29-36	interleukin 1 alpha	Homo sapiens	75-83
32446877-7	2020	By activating NF-kappaB signaling, IL-1beta induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E2 (PGE2) from tanycytes.	Dinoprostone	142-158	interleukin 1 alpha	Homo sapiens	35-43
32446877-7	2020	By activating NF-kappaB signaling, IL-1beta induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E2 (PGE2) from tanycytes.	Dinoprostone	160-164	interleukin 1 alpha	Homo sapiens	35-43
32538272-0	2020	Multi-walled carbon nanotubes induce IL-1beta secretion by activating hemichannels-mediated ATP release in THP-1 macrophages.	Carbon	13-19	interleukin 1 alpha	Homo sapiens	37-45
32538272-0	2020	Multi-walled carbon nanotubes induce IL-1beta secretion by activating hemichannels-mediated ATP release in THP-1 macrophages.	Adenosine Triphosphate	92-95	interleukin 1 alpha	Homo sapiens	37-45
32538272-4	2020	Our results showed that the unmodified and COOH MWCNTs could induce ATP release and ATP-P2X7R axis-dependent IL-1beta secretion from THP-1 macrophages.	Carbonic Acid	43-47	interleukin 1 alpha	Homo sapiens	109-117
32538272-7	2020	Inhibition of hemichannels by CBX, 43Gap27, or 10Panx1 pretreatment results in decreased ATP and IL-1beta release.	Carboxin	30-33	interleukin 1 alpha	Homo sapiens	97-105
32538272-8	2020	The addition of ATP restored the reduced IL-1beta secretion level from hemichannel inhibition.	Adenosine Triphosphate	16-19	interleukin 1 alpha	Homo sapiens	41-49
32538272-10	2020	Taken together, we conclude that hemichannels-mediated ATP release and subsequent NLRP3 inflammasome activation through P2X7R may be one mechanism by which MWCNTs induce macrophage IL-1beta secretion.	Adenosine Triphosphate	55-58	interleukin 1 alpha	Homo sapiens	181-189
32249518-8	2020	Carvacrol had a positive effect on the reduction of interleukin (IL)-1beta, IL-4, IL-8 and malondialdehyde (MDA); however, the analysis indicated that carvacrol had no effect on IL-6 and tumor necrosis factor alpha (TNF-alpha), probably due to the methodological quality of the studies and their heterogeneity.	carvacrol	0-9	interleukin 1 alpha	Homo sapiens	52-74
32634445-3	2020	We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1beta, and TNF-alpha).	SODIUM PYRUVATE	32-47	interleukin 1 alpha	Homo sapiens	182-190
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	Adenosine	24-33	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	goitrin	35-45	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	Chlorogenic Acid	47-63	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	caffeic acid	65-77	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	chicoric acid	79-92	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	corynoline	94-104	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	baicalin	106-114	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	wogonoside	116-126	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	wogonin	128-135	interleukin 1 alpha	Homo sapiens	240-260
33164356-4	2020	The results showed that adenosine, epigoitrin, chlorogenic acid, caffeic acid, cichoric acid, corynoline, baicalin, wogonoside, wogonin and oroxylin A had a certain regulatory effect on inflammatory factor tumor necrosis factor(TNF-alpha), interleukin(IL-1beta) and IL-6 at specific concentrations in a dose-dependent manner.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	140-150	interleukin 1 alpha	Homo sapiens	240-260
32861242-10	2020	Upon exposure to pyroptotic stimuli (ATP or nigericin), human microglia displayed caspase-3/7 activation and cleavage of caspase-3/7-specific substrates (e.g., DFF45, ROCK1, and PARP), with accompanying features of pyroptosis including GSDMD immunopositive pyroptotic bodies, IL-1beta release, and membrane rupture.	Adenosine Triphosphate	37-40	interleukin 1 alpha	Homo sapiens	276-284
32861242-10	2020	Upon exposure to pyroptotic stimuli (ATP or nigericin), human microglia displayed caspase-3/7 activation and cleavage of caspase-3/7-specific substrates (e.g., DFF45, ROCK1, and PARP), with accompanying features of pyroptosis including GSDMD immunopositive pyroptotic bodies, IL-1beta release, and membrane rupture.	Nigericin	44-53	interleukin 1 alpha	Homo sapiens	276-284
32874136-8	2020	Additionally, in both the rabbit trauma model and cellular injury model, CAA combined with high-dosage of VB6 inhibited the expression of inflammatory factors (IL-6, TNF-alpha and IL-1beta) and proteins (HMGB1, TLR4 and p-p65) in HMGB1/TLR4/NF-kappaB pathway.	caa	73-76	interleukin 1 alpha	Homo sapiens	180-188
32973567-8	2020	HBD4 down-regulated the expression of inflammatory mediators (i.e., IL-1alpha, IL-1beta, IL-6, TNF-alpha) in LPS-stimulated DPSC, and suppressed MAPK activity and the NF-kappaB pathway.	dpsc	124-128	interleukin 1 alpha	Homo sapiens	68-77
32778760-3	2020	IL-1 induced recruitment of IRAK2 Myddosome to mitochondria outer membranes via recognition by TOM20, followed by TIMM50-guided translocation of IRAK2 into mitochondria inner membranes, to suppress oxidative phosphorylation and fatty acid oxidation, thereby attenuating energy expenditure.	Fatty Acids	228-238	interleukin 1 alpha	Homo sapiens	0-4
32906646-9	2020	Abeta1-42 dose-dependently (IC50 = 2.54 microM) reversed the inhibitory effect of canonical and non-canonical nicotinic agonists on BzATP-mediated IL-1beta-release by monocytic cells, whereas reverse Abeta42-1 was ineffective.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	132-137	interleukin 1 alpha	Homo sapiens	147-155
32712318-6	2020	By conducting overexpression and rescue experiments, overexpression of miR-340-5p was evidenced to inhibit proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) and inflammation via reducing IL-1beta and IL-6 levels.	mir-340-5p	71-81	interleukin 1 alpha	Homo sapiens	214-222
32954194-4	2020	Ropivacaine treatment exerted significant beneficial effects by rescuing oxidative stress and downregulating interleukin (IL)-1beta and IL-18.	Ropivacaine	0-11	interleukin 1 alpha	Homo sapiens	109-131
32867889-9	2020	Gender-differentiated correlations of VFA with clinical and inflammatory variables were observed in age, FeNO, immunoglobulin E, blood total white cells and neutrophils, and sputum IL-1beta and IL-8.	Fatty Acids, Volatile	38-41	interleukin 1 alpha	Homo sapiens	181-189
32882839-8	2020	Irisin also reversed Sirt3 and UCP-1 pathways, thereby improving mitochondrial membrane potential, ATP production, and catalase to attenuated IL-1beta-mediated reactive oxygen radical production, mitochondrial fusion, mitophagy, and autophagosome formation.	reactive	160-168	interleukin 1 alpha	Homo sapiens	142-150
32882839-8	2020	Irisin also reversed Sirt3 and UCP-1 pathways, thereby improving mitochondrial membrane potential, ATP production, and catalase to attenuated IL-1beta-mediated reactive oxygen radical production, mitochondrial fusion, mitophagy, and autophagosome formation.	Reactive Oxygen Species	169-183	interleukin 1 alpha	Homo sapiens	142-150
32663626-6	2020	A better understanding of the pathological role of IL-1 family cytokines in autoimmunity involves a deeper evaluation, in the pathological situations, of the possible anomalies in the feed-back anti-inflammatory mechanisms that in physiological reactions control and dump IL-1-mediated inflammation.	2'-deoxyuridylic acid	267-271	interleukin 1 alpha	Homo sapiens	51-55
32663626-6	2020	A better understanding of the pathological role of IL-1 family cytokines in autoimmunity involves a deeper evaluation, in the pathological situations, of the possible anomalies in the feed-back anti-inflammatory mechanisms that in physiological reactions control and dump IL-1-mediated inflammation.	2'-deoxyuridylic acid	267-271	interleukin 1 alpha	Homo sapiens	272-276
32713853-0	2020	Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1beta-Stimulated Human FLS Cells.	fangchinoline	0-13	interleukin 1 alpha	Homo sapiens	71-79
32564453-8	2020	RESULTS: Compared to PF and PQ groups, mRNA and protein expression of IL-6, IL-8, and IL-1beta increased in samples from the BAK group in a time-dependent fashion, whereas all other cytokines showed a non-significant increase.	Benzalkonium Compounds	125-128	interleukin 1 alpha	Homo sapiens	86-94
32564453-9	2020	In the BAK group, there was a strong correlation between OSDI and the levels of IC/IL-1beta (r=0.832, R squared=0.692 and p=0.040); IC/IL-10 (r=0.925, R squared=0.856 and p=0.008) and tear/IL-1beta (r=0.899, R squared=0.808 and p=0.014).	Benzalkonium Compounds	7-10	interleukin 1 alpha	Homo sapiens	83-91
32623773-5	2020	RESULTS: Our in vitro experiments showed that the poly(I:C)-induced innate production of IFN-lambda in human infant AECs is regulated by: I) p38-MAPK/NF-kB dependent mechanism; and II) exposure to pro-inflammatory signals such as IL1beta.	Poly I-C	50-59	interleukin 1 alpha	Homo sapiens	230-237
32964957-11	2020	Surprisingly, the treatment with SF1670 could significantly reverse the regulatory effects of IL-1beta.	SF1670	33-39	interleukin 1 alpha	Homo sapiens	94-102
32964957-12	2020	Moreover, relative levels of IL-6, IL-8, TNF-alpha, and MMP3/9/13 were significantly suppressed by SF1670 stimuli compared with IL-1beta group.	SF1670	99-105	interleukin 1 alpha	Homo sapiens	128-136
32962811-4	2020	The expression of four key genes involved in inflammation and apoptosis including IL-8, IL-1beta, IL-10 and Bcl2 depicted that the MTX-SA had controversial behavior in different doses on the inflammatory transcription.	mtx-sa	131-137	interleukin 1 alpha	Homo sapiens	88-96
32744052-0	2020	IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra).	throboxane-a2	13-26	interleukin 1 alpha	Homo sapiens	0-4
32744052-0	2020	IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra).	Thromboxane A2	28-32	interleukin 1 alpha	Homo sapiens	0-4
32744052-13	2020	IL-1 causes platelet vascular thrombogenicity also on non-endothelial cells by stimulating the formation of thromboxane A2 which is released into the inflamed environment.	Thromboxane A2	108-122	interleukin 1 alpha	Homo sapiens	0-4
32744052-14	2020	IL-1 is the most important immune molecule in inducing fever, since it is involved in the metabolism of arachidonic acid which increases from vascular endothelial organs of the hypothalamus.	Arachidonic Acid	104-120	interleukin 1 alpha	Homo sapiens	0-4
32744052-19	2020	1986 Jul;32(1):111-5), we reported for the first time that IL-1 induces thromboxane B2 (TxB2) releases in activated neutrophils and macrophages.	Thromboxane B2	72-86	interleukin 1 alpha	Homo sapiens	59-63
32744052-19	2020	1986 Jul;32(1):111-5), we reported for the first time that IL-1 induces thromboxane B2 (TxB2) releases in activated neutrophils and macrophages.	Thromboxane B2	88-92	interleukin 1 alpha	Homo sapiens	59-63
32744052-26	2020	However, in some serious vascular events where TxA2 increases significantly, it is difficult to inhibit, therefore, it would be much better to prevent its induction and generation by blocking its inductors including IL-1.	Thromboxane A2	47-51	interleukin 1 alpha	Homo sapiens	216-220
32945158-0	2020	Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19.	Histamine	43-52	interleukin 1 alpha	Homo sapiens	69-73
32945158-14	2020	IL-1 in combination with histamine can cause a strong increase of IL-1 levels and, consequently, a higher degree of inflammation.	Histamine	25-34	interleukin 1 alpha	Homo sapiens	66-70
32945158-16	2020	Furthermore, histamine enhances IL-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral monocytes.	Histamine	13-22	interleukin 1 alpha	Homo sapiens	32-36
32945158-17	2020	Therefore, since MCs are large producers of histamine in inflammatory reactions, this vasoactive amine, by increasing the production of IL-1, can amplify the inflammatory process in the lung infected with SARS-CoV-2.	Histamine	44-53	interleukin 1 alpha	Homo sapiens	136-140
32945158-17	2020	Therefore, since MCs are large producers of histamine in inflammatory reactions, this vasoactive amine, by increasing the production of IL-1, can amplify the inflammatory process in the lung infected with SARS-CoV-2.	Amines	48-53	interleukin 1 alpha	Homo sapiens	136-140
32945158-18	2020	Here, we have proposed for the first time an emerging role for histamine released by MCs which in combination with IL-1 can cause an increase in lung inflammation induced by the viral infection SARS-CoV-2.	Histamine	63-72	interleukin 1 alpha	Homo sapiens	115-119
32015430-6	2020	Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses.	monobutyl phthalate	0-22	interleukin 1 alpha	Homo sapiens	56-64
32015430-6	2020	Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses.	monobutyl phthalate	24-27	interleukin 1 alpha	Homo sapiens	56-64
32035094-7	2020	Treatment with ATP caused the activation of caspase-1 as well as the production of active forms of IL-1beta and IL-18 via P2X7 receptor (P2X7R) in keratinocytes and melanocytes.	Adenosine Triphosphate	15-18	interleukin 1 alpha	Homo sapiens	99-107
32717457-5	2020	RESULTS: In animal experiments, the combined oral administration of CP and EP increased the contents of collagen and elastin in animal skin, accompanying with significantly upregulated expression of hyaluronic acid and hydroxyproline, as well as significantly reduced expression of MMP-3 and IL-1alpha.	ep	75-77	interleukin 1 alpha	Homo sapiens	292-301
32504751-7	2020	Such positive outcomes were underlined by a significant inhibitory effect of nifuroxazide on lung and heart contents of toll-like receptor (4) (TLR4)/the inflammasome NALPR3/interleukin- 1beta (IL-1beta).	nifuroxazide	77-89	interleukin 1 alpha	Homo sapiens	194-202
32504751-8	2020	In conclusion: Nifuroxazide attenuates LPS-induced ALI and myocardial injury via interruption of TLR4/NALPR3/IL-1beta signaling.	nifuroxazide	15-27	interleukin 1 alpha	Homo sapiens	109-117
32705171-7	2020	Moreover, nucleus pulposus cells isolated from patients with IDD contained less cytoplasm compared with normal nucleus pulposus cells, and p65 expression levels were higher in the cytoplasm than the nucleus of IL-1beta-stimulated PDTC-treated healthy nucleus pulposus cells.	pyrrolidine dithiocarbamic acid	230-234	interleukin 1 alpha	Homo sapiens	210-218
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	interleukin 1 alpha	Homo sapiens	257-265
32888128-0	2020	The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1beta protein.	Resveratrol	26-37	interleukin 1 alpha	Homo sapiens	97-105
32888128-12	2020	After treatment with Resveratrol, both IL-1beta mRNA and protein levels were reduced, while IL-11 protein levels showed any increase.	Resveratrol	21-32	interleukin 1 alpha	Homo sapiens	39-47
32888128-14	2020	Resveratrol can reverse the inflammatory effects of TNF-alpha by reducing IL-1beta and increasing IL-11 production.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	74-82
32797769-3	2020	Moreover, ELISA assay showed that acacetin dose-dependently attenuated LPS-induced increases of TNF-alpha, IL-6 and IL-1beta in PDL cells.	acacetin	34-42	interleukin 1 alpha	Homo sapiens	116-124
32863237-0	2020	Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1beta production and inflammatory apoptosis at high dose.	itaconic acid	34-43	interleukin 1 alpha	Homo sapiens	89-97
32863237-5	2020	We found that exposure of bone marrow-derived dendritic cells (BMDCs) to low concentrations of a variety of electrophilic Nrf2 activators including itaconate prior to Toll-like receptor (TLR) stimulation inhibits transcription of pro-inflammatory cytokines (such as interleukin [IL]-12 and IL-1beta) by activation of Nrf2.	itaconic acid	148-157	interleukin 1 alpha	Homo sapiens	290-298
32878107-4	2020	BCU decreased the serum concentration of IgG, IL-2, IFN-gamma, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1beta, IgG, IL-2, IFN-gamma, IgA, IL-6, IgM, and TNFalpha in normal piglets (p < 0.05).	(3r)-3,4-Dihydro-2h-Chromen-3-Ylmethanol	0-3	interleukin 1 alpha	Homo sapiens	146-154
32872542-7	2020	Finally, polyCD@Ada-Rhod/DCF significantly suppressed IL-1 production in hMSCs, revealing the anti-inflammatory properties of these nanoassemblies.	polycd	9-15	interleukin 1 alpha	Homo sapiens	54-58
32908567-11	2020	There were medium-to-strong correlation between CML with SOD (r = 0.58, p < 0.05) and IL-1alpha with SOD (r = 0.70, p < 0.05) in well-controlled blood glucose.	Glucose	151-158	interleukin 1 alpha	Homo sapiens	86-95
32841225-0	2020	Dioscin Attenuates Interleukin 1beta (IL-1beta)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-kappaB) Signaling in Human Nucleus Pulposus Cells.	dioscin	0-7	interleukin 1 alpha	Homo sapiens	38-46
32841225-6	2020	RESULTS Dioscin inhibited IL-1ss-activated apoptotic signaling and catabolic activity in NP cells.	dioscin	8-15	interleukin 1 alpha	Homo sapiens	26-30
32841225-7	2020	Dioscin suppressed TLR4/NF-0kappaB signaling, and attenuated the level of inflammatory mediators (IL-6, TNF-alpha) in IL-1ss-stimulated human NP cells.	dioscin	0-7	interleukin 1 alpha	Homo sapiens	118-122
32841225-8	2020	CONCLUSIONS Our work provides the first evidence that dioscin attenuates IL-1ss-activated inflammation and catabolic activity in human NP cells through inhibiting the TLR4/NF-kappaB pathway, indicating that dioscin is a new potential candidate for clinical therapy to attenuate disc degeneration.	dioscin	54-61	interleukin 1 alpha	Homo sapiens	73-77
32827051-5	2021	We found that repeated morphine treatment promoted astrocyte activation in the spinal dorsal horn (SDH) and up-regulation of pro-inflammatory cytokines IL-1beta and TNF-alpha.	Morphine	23-31	interleukin 1 alpha	Homo sapiens	152-160
32842681-0	2020	Oxyresveratrol Inhibits IL-1beta-Induced Inflammation via Suppressing AKT and ERK1/2 Activation in Human Microglia, HMC3.	puag-haad	0-14	interleukin 1 alpha	Homo sapiens	24-32
32842681-4	2020	We demonstrated that OXY strongly decreased the release of IL-6 and MCP-1 from HMC3 cells stimulated with IL-1beta.	puag-haad	21-24	interleukin 1 alpha	Homo sapiens	106-114
32842681-7	2020	We discovered that OXY exerted its anti-inflammatory role in IL-1beta-induced HMC3 cells by suppressing IL-1beta-induced activation of the PI3K/AKT/p70S6K pathway.	puag-haad	19-22	interleukin 1 alpha	Homo sapiens	61-69
32842681-7	2020	We discovered that OXY exerted its anti-inflammatory role in IL-1beta-induced HMC3 cells by suppressing IL-1beta-induced activation of the PI3K/AKT/p70S6K pathway.	puag-haad	19-22	interleukin 1 alpha	Homo sapiens	104-112
32842681-11	2020	These findings suggest that the possible anti-inflammatory mechanisms of OXY in IL-1beta-induced HMC3 cells are mainly through its ability to suppress the PI3K/AKT/p70S6K and ERK1/2 MAPK signal transduction cascades.	puag-haad	73-76	interleukin 1 alpha	Homo sapiens	80-88
32842681-12	2020	In conclusion, our study provided accumulated data that OXY is able to suppress IL-1beta stimulation signaling in human microglial cells, and we believe that OXY could be a probable pharmacologic agent for altering microglial function in the treatment of neuroinflammation.	puag-haad	56-59	interleukin 1 alpha	Homo sapiens	80-88
32842681-12	2020	In conclusion, our study provided accumulated data that OXY is able to suppress IL-1beta stimulation signaling in human microglial cells, and we believe that OXY could be a probable pharmacologic agent for altering microglial function in the treatment of neuroinflammation.	puag-haad	158-161	interleukin 1 alpha	Homo sapiens	80-88
32519707-10	2020	Moreover, the overexpression of transcription factor EB (TFEB), the master transcriptional regulator of autophagy and lysosome biogenesis, partially relieved arsenic-inhibited lysosomal CTSD and CTSL expressions, recovered the disorder of autophagic flux, promoted the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-12, and reduced anti-inflammatory cytokine IL-10 secretion.	Arsenic	158-165	interleukin 1 alpha	Homo sapiens	321-329
32929357-10	2020	Cholesterol stimulated the protein expression of NLRP3 inflammasome components ASC, caspase-1 and IL-1beta, and decreased AQP2 protein abundance in vitro, which was markedly prevented by statins, likely through the enhancement of ASC speck degradation via autophagy.	Cholesterol	0-11	interleukin 1 alpha	Homo sapiens	98-106
32824426-9	2020	Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1beta, and TNFalpha in FLS.	pd9805	78-84	interleukin 1 alpha	Homo sapiens	177-185
32908546-12	2020	Our findings suggest that a DPMSCs treatment based on DPMSCs has both an effect on bone regeneration linked to an increased SOD and decreased levels of IL1beta in aging subjects with PD.	dpmscs	28-34	interleukin 1 alpha	Homo sapiens	152-159
32908546-12	2020	Our findings suggest that a DPMSCs treatment based on DPMSCs has both an effect on bone regeneration linked to an increased SOD and decreased levels of IL1beta in aging subjects with PD.	dpmscs	54-60	interleukin 1 alpha	Homo sapiens	152-159
32804985-7	2020	In addition to the effects of KW3110 on J774A.1 cells, KW3110 treatment induced IL-10 production in the supernatants of human monocytes, and KW3110 or IL-10 treatment suppressed caspase-1 activation and IL-1beta production in the supernatants of LPS/ATP-stimulated cells.	kw3110	55-61	interleukin 1 alpha	Homo sapiens	203-211
32804985-7	2020	In addition to the effects of KW3110 on J774A.1 cells, KW3110 treatment induced IL-10 production in the supernatants of human monocytes, and KW3110 or IL-10 treatment suppressed caspase-1 activation and IL-1beta production in the supernatants of LPS/ATP-stimulated cells.	kw3110	55-61	interleukin 1 alpha	Homo sapiens	203-211
32824426-9	2020	Co-inhibition of ERK and JNK signaling pathways by their specific inhibitors (PD9805 and SP600125, respectively) resulted in the suppression of mRNA and protein levels of IL-6, IL-1beta, and TNFalpha in FLS.	pyrazolanthrone	89-97	interleukin 1 alpha	Homo sapiens	177-185
32470450-7	2020	We found that OGD/R induced the expression of IL-1 beta, IL-6, TNF-alpha in the supernatant of microglia; OGD/R and these proinflammatory cytokines promoted the mRNA as well as protein expression of XBP1u, XBP1s and cleaved caspase-3, increased the ratio of p-IRE1alpha/IRE1alpha, as well as apoptosis, and decreased cell viability in primary cortical neurons, while ICA reversed the levels of the above factors.	icariin	367-370	interleukin 1 alpha	Homo sapiens	46-55
32903465-10	2020	Furthermore, isoquercitrin treatment reduced the levels of inflammatory factors-interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha)-in the target muscle and inactivated the JAK/STAT3 signaling pathway.	isoquercitrin	13-26	interleukin 1 alpha	Homo sapiens	72-102
32806763-12	2020	RIH/glucose fluctuations also induced M1 polarization and an inflammatory profile (CD11c, IL-1beta, TNF-alpha, IL-6, and monocyte chemoattractant protein (MCP)-1) in macrophages.	Glucose	4-11	interleukin 1 alpha	Homo sapiens	90-98
32982316-3	2020	Objective: We hypothesized that 1,25(OH)2D3 opposes the TGF-beta1 or tumor necrosis factor alpha (TNF-alpha)-Interleukin 1 beta (IL-1beta) stimulation on airway fibroblast profibrogenic secretory phenotype observed in severe asthmatic patients.	(oh)2d3	36-43	interleukin 1 alpha	Homo sapiens	129-137
32982316-4	2020	Our aim was to investigate the anti-fibrogenic effect of 1,25(OH)2D3 in TGF-beta1 or TNF-alpha-IL-1beta-stimulated human bronchial fibroblast cells (HBFCs) from severe asthmatic compared with non-asthmatic subjects.	Calcitriol	57-68	interleukin 1 alpha	Homo sapiens	95-103
32982316-11	2020	Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs.	Calcitriol	144-155	interleukin 1 alpha	Homo sapiens	195-203
32781843-6	2021	Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha).	dda	13-16	interleukin 1 alpha	Homo sapiens	223-231
32781843-6	2021	Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha).	diphtheria toxin fragment A	21-24	interleukin 1 alpha	Homo sapiens	223-231
32376366-0	2020	Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1beta-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology.	dolichosin a	0-12	interleukin 1 alpha	Homo sapiens	67-75
32782316-0	2020	KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1beta from PBMCs in a patient with Muckle-Wells syndrome.	kn3014	0-6	interleukin 1 alpha	Homo sapiens	75-83
32782316-0	2020	KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1beta from PBMCs in a patient with Muckle-Wells syndrome.	piperidine	10-20	interleukin 1 alpha	Homo sapiens	75-83
32376366-7	2020	Anti-arthritic effects of DoA and predicted mechanisms were further validated using IL-1beta-induced SW982 human synovial cell model and RANKL-induced osteoclastogenesis model.	dioctyl adipate	26-29	interleukin 1 alpha	Homo sapiens	84-92
32376366-10	2020	Furthermore, we found that DoA could significantly inhibit IL-1beta-induced inflammation in SW982 human synovial cells, as evidenced by the decreased levels of pro-inflammatory mediators (TNF-alpha, IL-6 and COX-2) and MMP-3.	dioctyl adipate	27-30	interleukin 1 alpha	Homo sapiens	59-67
32793908-8	2020	TMPRSS2, inflammatory cytokines G-CSF, M- CSF, IL-1a, IL-6 and MCP-1 are suppressed by MEKi alone or in combination with remdesivir.	remdesivir	121-131	interleukin 1 alpha	Homo sapiens	47-52
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	interleukin 1 alpha	Homo sapiens	260-269
32851082-0	2020	Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1beta and IL-18 in the Septic Response.	Sirolimus	0-9	interleukin 1 alpha	Homo sapiens	58-66
32851082-8	2020	This study shows that RAPA abrogates LPS-mediated increase in IL-1beta and IL-18 by inhibiting pyroptosis and enhancing autophagy.	Sirolimus	22-26	interleukin 1 alpha	Homo sapiens	62-70
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	DEAE-Dextran	2-27	interleukin 1 alpha	Homo sapiens	198-206
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	DEAE-Dextran	29-37	interleukin 1 alpha	Homo sapiens	198-206
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	ferric oxide	72-82	interleukin 1 alpha	Homo sapiens	198-206
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	interleukin 1 alpha	Homo sapiens	68-76
32953809-10	2020	When studied in vitro, TMAO treatment significantly promoted BMSCs adipogenesis and attenuated osteogenesis, increased ROS release and pro-inflammatory cytokine IL-1beta, IL-6 and TNF-alpha production, and inhibited cell proliferation.	trimethyloxamine	23-27	interleukin 1 alpha	Homo sapiens	161-169
32530527-9	2020	Both high mobility group box 1 derived from MPM cells and asbestos-activated inflammasome in TAMs induced the production of IL-1beta, which resulted in enhancing the malignant potential of MPM.	tams	93-97	interleukin 1 alpha	Homo sapiens	124-132
32305864-4	2020	Herein, we developed an in vivo electrochemical immunosensing device based on glassy carbon rod to simultaneously detect three proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha).	Carbon	85-91	interleukin 1 alpha	Homo sapiens	154-162
32470548-4	2020	Furthermore, the recombinant protein blocked reactive oxygen species (ROS) production, abated mitochondrial dysfunction and significantly suppressed the assembly of the inflammasome, which led to the overproduction of proinflammatory cytokines IL-1beta and IL-18.	Reactive Oxygen Species	45-68	interleukin 1 alpha	Homo sapiens	244-252
32470548-4	2020	Furthermore, the recombinant protein blocked reactive oxygen species (ROS) production, abated mitochondrial dysfunction and significantly suppressed the assembly of the inflammasome, which led to the overproduction of proinflammatory cytokines IL-1beta and IL-18.	Reactive Oxygen Species	70-73	interleukin 1 alpha	Homo sapiens	244-252
32530527-11	2020	In conclusion, interaction between MPM cells and TAMs through IL-1beta/IL-1R signal could be a promising candidate as target for novel treatment of MPM (Hyogo College of Medicine clinical trial registration number: 2973).	tams	49-53	interleukin 1 alpha	Homo sapiens	62-70
31912349-0	2020	Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1alpha, IL-1beta and TNF-alpha Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder.	single-nucleotide	35-52	interleukin 1 alpha	Homo sapiens	70-79
31912349-0	2020	Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1alpha, IL-1beta and TNF-alpha Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder.	single-nucleotide	35-52	interleukin 1 alpha	Homo sapiens	81-89
32742379-5	2020	Further investigation in RAW264.7 macrophages revealed that CAI decreased the production of nitric oxide via decreasing the LPS-stimulated expression of inducible nitric oxide synthase, and downregulated both mRNA and protein expression levels of the cytokines tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6.	carboxyamido-triazole	60-63	interleukin 1 alpha	Homo sapiens	290-312
32176433-7	2020	The use of S. aureus deletion and complemented phenole soluble modulins (PSMs) mutants demonstrated a key role of PSMs in inflammasomes-related IL-1beta production.	Phenol	47-54	interleukin 1 alpha	Homo sapiens	144-152
32417162-0	2020	Stachydrine attenuates IL-1beta-induced inflammatory response in osteoarthritis chondrocytes through the NF-kappaB signaling pathway.	stachydrine	0-11	interleukin 1 alpha	Homo sapiens	23-31
32417162-8	2020	Our results showed that STA significantly suppressed IL-1beta-induced inflammation with decreased levels of inflammatory mediators and cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha and IL-6.	stachydrine	24-27	interleukin 1 alpha	Homo sapiens	53-61
32417162-8	2020	Our results showed that STA significantly suppressed IL-1beta-induced inflammation with decreased levels of inflammatory mediators and cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha and IL-6.	Dinoprostone	159-163	interleukin 1 alpha	Homo sapiens	53-61
32417162-9	2020	Treatment with STA suppressed the production of ECM degrading enzymes including MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 in IL-1beta-induced chondrocytes.	stachydrine	15-18	interleukin 1 alpha	Homo sapiens	121-129
32141013-12	2020	Molecular docking analysis demonstrated strong binding interaction of amlodipine with TNF-alpha, IL-6 and IL-1beta thus providing a good correlation between experimental and theoretical results.	Amlodipine	70-80	interleukin 1 alpha	Homo sapiens	106-114
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	228-231	interleukin 1 alpha	Homo sapiens	155-163
32239395-11	2020	Our results showed that pyroptosis and IL-1beta release were attenuated by nicardipine, but not verapamil.	Nicardipine	75-86	interleukin 1 alpha	Homo sapiens	39-47
32141013-11	2020	Gene expression level of TNF-alpha, IL-6 and IL-1beta was significantly reduced by amlodipine while an increase in expression level of IL-4 and IL-10 was evident in animals treated with piroxicam and amlodipine.	Amlodipine	83-93	interleukin 1 alpha	Homo sapiens	45-53
32515238-0	2020	Dioscin exhibits anti-inflammatory effects in IL-1beta-stimulated human osteoarthritis chondrocytes by activating LXRalpha.	dioscin	0-7	interleukin 1 alpha	Homo sapiens	46-54
32515238-2	2020	In this study, we aimed to investigate the anti-inflammatory activity of dioscin on IL-1beta-stimulated human osteoarthritis chondrocytes.Methods: The production of PGE2 and NO was measured in this study.	dioscin	73-80	interleukin 1 alpha	Homo sapiens	84-92
32542545-0	2020	Correction to: Garcinol Suppresses IL-1beta-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-kappaB Signaling Pathway.	garcinol	15-23	interleukin 1 alpha	Homo sapiens	35-43
32515238-6	2020	Furthermore, dioscin inhibited the phosphorylation of NF-kappaB p65 and IkappaBalpha induced by IL-1beta.	dioscin	13-20	interleukin 1 alpha	Homo sapiens	96-104
32515238-7	2020	The degradation of IkappaBalpha induced by IL-1beta was also suppressed by dioscin.	dioscin	75-82	interleukin 1 alpha	Homo sapiens	43-51
32450530-3	2020	Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways.	Nitric Oxide	113-125	interleukin 1 alpha	Homo sapiens	71-79
32106337-11	2020	Positive correlations between IL-1beta levels and TBARS and between IL-1beta levels and LC3-II were found only in control subjects.	Thiobarbituric Acid Reactive Substances	50-55	interleukin 1 alpha	Homo sapiens	30-38
32626912-3	2020	Overexpression of miR-185-5p in NP cells markedly inhibited the enhanced extracellular matrix (ECM) catabolism induced by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) treatment.	-185-5p	21-28	interleukin 1 alpha	Homo sapiens	185-193
32141102-5	2020	DBT was shown to decrease IL-1beta and IL-6 secretion from immune cells at higher concentrations while causing increases at lower concentrations.	di-n-butyltin	0-3	interleukin 1 alpha	Homo sapiens	26-34
32141102-10	2020	The 24-h exposures to DBT decreased production of both IL-1beta and IL-6 at the two highest concentrations but increased production at lower concentrations.	di-n-butyltin	22-25	interleukin 1 alpha	Homo sapiens	55-63
32016419-5	2020	Treatment of A549 cells with IL-1beta induced the activation of p38 mitogen-activated protein kinase (MAP kinase) and MAP kinase-activated protein kinase-2 (MAPKAPK-2), as well as EGFR phosphorylation at serine 1047.	cholecystokinin C-terminal flanking peptide	204-210	interleukin 1 alpha	Homo sapiens	29-37
32567290-2	2020	Therefore, the aim of this study was to determine the effect of vitamin A and D combination supplement on interleukin-1beta (IL-1beta) and clinical outcome in ischemic stroke.	Vitamin A	64-73	interleukin 1 alpha	Homo sapiens	125-133
32428244-11	2020	Overall, we found that host-derived cytokines TNF and IL-1alpha stimulated reactive oxygen species and a large repertoire of cytokines.	Reactive Oxygen Species	75-98	interleukin 1 alpha	Homo sapiens	54-63
32567290-2	2020	Therefore, the aim of this study was to determine the effect of vitamin A and D combination supplement on interleukin-1beta (IL-1beta) and clinical outcome in ischemic stroke.	Deuterium	78-79	interleukin 1 alpha	Homo sapiens	125-133
32567290-10	2020	Conclusion Administration of combination of vitamin A and D supplementation can significantly increase vitamin A and D serum level, decrease IL-1beta serum level, and ultimately improve clinical outcome in ischemic stroke patients.	Vitamin A	44-53	interleukin 1 alpha	Homo sapiens	141-149
32567290-10	2020	Conclusion Administration of combination of vitamin A and D supplementation can significantly increase vitamin A and D serum level, decrease IL-1beta serum level, and ultimately improve clinical outcome in ischemic stroke patients.	Deuterium	58-59	interleukin 1 alpha	Homo sapiens	141-149
32567290-10	2020	Conclusion Administration of combination of vitamin A and D supplementation can significantly increase vitamin A and D serum level, decrease IL-1beta serum level, and ultimately improve clinical outcome in ischemic stroke patients.	vitamin a and d	44-59	interleukin 1 alpha	Homo sapiens	141-149
32533463-8	2020	In addition, miR-194-5p inhibited the release of COX2 and pro-inflammatory cytokines (TNF-alpha, TGF-beta, IL-1beta and IL-6).	mir-194-5p	13-23	interleukin 1 alpha	Homo sapiens	107-115
32467994-9	2020	Moreover, HG treatment induced inflammation by upregulating tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 expression.	Mercury	10-12	interleukin 1 alpha	Homo sapiens	89-111
32468015-4	2020	Therefore, the aim of the present study was to investigate the effect of AK094629 on IL-1beta-induced IL-6 expression in synovial-derived mesenchymal stem cells (SMSCs) of the temporomandibular joints.	ak094629	73-81	interleukin 1 alpha	Homo sapiens	85-93
32468015-7	2020	The present study also demonstrated that AK094629 knockdown downregulated the expression of the mitogen-activated protein kinase kinase kinase 4 (MAP3K4), which is upregulated by IL-1beta, whereas knockdown of MAP3K4 did not affect the expression of AK094629, but reversed the upregulation of IL-6 in SMSCs.	ak094629	41-49	interleukin 1 alpha	Homo sapiens	179-187
32468015-8	2020	In conclusion, AK094629 knockdown attenuated the expression of IL-1beta-regulated IL-6 in the SMSCs of the temporomandibular joint by inhibiting MAP3K4.	ak094629	15-23	interleukin 1 alpha	Homo sapiens	63-71
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	y-vad	87-92	interleukin 1 alpha	Homo sapiens	19-27
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	y-vad	87-92	interleukin 1 alpha	Homo sapiens	62-70
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	y-vad	87-92	interleukin 1 alpha	Homo sapiens	62-70
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	z-vad	154-159	interleukin 1 alpha	Homo sapiens	19-27
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	z-vad	154-159	interleukin 1 alpha	Homo sapiens	62-70
32335355-8	2020	We found decreased IL-1beta secretion 2154 pg/ml to 854 pg/ml IL-1beta secretion using Y-VAD and we observed decrease from 2154 pg/ml to 22.33 pg/ml with Z-VAD, and this inhibition was followed by diminished viral replication from 2.25 x 107 to 2.1 x 105 CCID50, which suggests that caspase 1-dependent secretion of the IL-1beta active molecule is important for viral replication.	z-vad	154-159	interleukin 1 alpha	Homo sapiens	62-70
32696949-5	2020	RESULTS:  Flow cytometry analysis showed that IL-1beta increased the apoptosis rate of nucleus pulposus cells in each group, and RES significantly decreased the apoptosis rate, while  rapamycin (RAPA) and SB216763 inhibited the effect of RES and increased the apoptosis rate again.	Resveratrol	0-3	interleukin 1 alpha	Homo sapiens	46-54
32578856-15	2020	CONCLUSION: NLRP3 could enhance resistance to gemcitabine via IL-1beta/EMT/Wnt/beta-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC.	CY5.5 cyanine dye	141-146	interleukin 1 alpha	Homo sapiens	62-70
32578856-15	2020	CONCLUSION: NLRP3 could enhance resistance to gemcitabine via IL-1beta/EMT/Wnt/beta-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC.	gemcitabine	174-185	interleukin 1 alpha	Homo sapiens	62-70
32696949-7	2020	RT-qPCR results showed IL-1beta significantly increased the level of caspase-3 expression, but it was significantly decreased by using RES, RAPA and SB216763 respectively attenuate effects of RES.	Sirolimus	140-144	interleukin 1 alpha	Homo sapiens	23-31
32696949-7	2020	RT-qPCR results showed IL-1beta significantly increased the level of caspase-3 expression, but it was significantly decreased by using RES, RAPA and SB216763 respectively attenuate effects of RES.	SB 216763	149-157	interleukin 1 alpha	Homo sapiens	23-31
32849554-2	2020	The NOD-, LRR- and pyrin domain containing protein 3 (NLRP3) is an innate immune signaling complex whose assembly and activation can be triggered by various signals ranging from microbial molecules to ATP or the abnormal accumulation of crystals, thus leading to IL-1beta and IL-18 maturation and secretion.	Adenosine Triphosphate	201-204	interleukin 1 alpha	Homo sapiens	263-271
32584575-7	2020	Analysis of IL-1beta and caspase-1 expression revealed that the new diterpenoids 15 and 18 are selective inhibitors of the NLRP3 inflammasome, reinforcing the previously demonstrated anti-inflammatory properties of hispanolone derivatives.	Diterpenes	68-80	interleukin 1 alpha	Homo sapiens	12-20
32751912-2	2020	More than half a decade ago, it has been shown that the inflammasome adaptor molecule, ASC requires tyrosine phosphorylation to allow effective inflammasome assembly and sustained IL-1beta/IL-18 release.	Tyrosine	100-108	interleukin 1 alpha	Homo sapiens	180-188
32751912-4	2020	In the subsequent years, it was reported that activation of the inflammasome receptor molecule, NLRP3, is modulated via tyrosine phosphorylation as well, and that NLRP3 de-phosphorylation at specific tyrosine residues was required for inflammasome assembly and sustained IL-1beta/IL-18 release.	Tyrosine	200-208	interleukin 1 alpha	Homo sapiens	271-279
32592999-5	2020	The oxidized DNA enhanced influenza virus-induced IL-1beta secretion, whereas inhibition of mitochondrial ROS production by antioxidant Mito-TEMPO decreased the virus-induced IL-1beta secretion.	Reactive Oxygen Species	106-109	interleukin 1 alpha	Homo sapiens	175-183
32849646-0	2020	Retraction: The Increase in IL-1beta in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome.	mtros	130-135	interleukin 1 alpha	Homo sapiens	28-36
32792961-4	2020	Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro.	tryptanthrine	5-9	interleukin 1 alpha	Homo sapiens	84-106
32792961-4	2020	Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro.	tryptanthrine	14-18	interleukin 1 alpha	Homo sapiens	84-106
32792961-4	2020	Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro.	tryptanthrine	14-18	interleukin 1 alpha	Homo sapiens	148-156
32792961-4	2020	Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro.	tryptanthrine	14-18	interleukin 1 alpha	Homo sapiens	84-106
32792961-4	2020	Both TRYP and TRYP-Ox inhibited matrix metalloproteinase (MMP)-3 gene expression in interleukin (IL)-1beta-stimulated primary human FLS, as well as IL-1beta-induced secretion of MMP-1/3 by FLS and synovial SW982 cells and IL-6 by FLS, SW982 cells, human umbilical vein endothelial cells (HUVECs), and monocytic THP-1 cells, although TRYP-Ox was generally more effective and had no cytotoxicity in vitro.	tryptanthrine	14-18	interleukin 1 alpha	Homo sapiens	148-156
32699419-9	2020	The ELISA assays showed that mature form of IL-1beta and IL-12p70 were increased, in extracellular compartments of FeH-stimulated macrophages.	(R)-(-)-1-Phenyl-1,2-ethanediol	115-118	interleukin 1 alpha	Homo sapiens	44-52
32793237-11	2020	These results indicate that SAHA promoted the early switch to glycolysis, increased IL-1beta, and reduced IL-10 production in human macrophages infected with Mtb.	Vorinostat	28-32	interleukin 1 alpha	Homo sapiens	84-92
32416450-6	2020	BCP exhibited anti-inflammatory activity with decreased levels of TNF-alpha, IL-1beta, IL-6 in HG-induced MCs.	caryophyllene	0-3	interleukin 1 alpha	Homo sapiens	77-85
33318875-7	2021	Double-silencing of endogenous H2S producing enzymes, Cystathionine gamma-lyase (CSE) and Cystathionine beta-synthase (CBS) in VIC exerted enhanced mineralization and higher levels of IL-1beta and TNF-alpha.	Deuterium	31-34	interleukin 1 alpha	Homo sapiens	184-192
32808940-4	2020	Studies show that colchicine, among other actions, inhibits the assembly of NLRP3 complex that is responsible for generating the active form of Caspase-1 that will convert Pro-IL-1beta and Pro-IL-18 into their active forms.	Colchicine	18-28	interleukin 1 alpha	Homo sapiens	176-184
32694701-11	2020	Pyrazinib significantly inhibited IL-1beta secretion (p = 0.0377) and increased IL-3 (p = 0.0020) and IL-17B (p = 0.0181).	SCHEMBL9791651	0-9	interleukin 1 alpha	Homo sapiens	34-42
32698510-12	2020	Ruxolitinib reverted IFN-gamma-induced expression of caspase-1, IL-1beta, IL-15, and IL-18, and stimulated several growth factors, such as FGF7.	ruxolitinib	0-11	interleukin 1 alpha	Homo sapiens	64-72
32698404-8	2020	Stimulation with Alcaligenes lipid A also induced the production of IL-6 and IL-1beta in human peripheral blood mononuclear cells.	Lipid A	29-36	interleukin 1 alpha	Homo sapiens	77-85
32311377-11	2020	E2 reduced the negative impact of menopause and aging on insulin sensitivity by favoring increase in the level of IL-10 and decrease in the levels of TNF-alpha and IL-1beta.	Estradiol	0-2	interleukin 1 alpha	Homo sapiens	164-172
32513828-5	2020	LPS suppression of locomotor activity correlated with blood glucose concentrations, was mitigated by exogenous glucose (2 g/kg), and was exacerbated by 2-deoxyglucose (2-DG) glycolytic inhibition, despite preventing IL-1beta synthesis.	Deoxyglucose	168-172	interleukin 1 alpha	Homo sapiens	216-224
32764938-8	2020	Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma).	beta-Glucans	9-20	interleukin 1 alpha	Homo sapiens	99-107
32661265-0	2020	Hypochlorite-induced porcine model of peritoneal fibrosis through the activation of IL1beta-CX3CL1-TGFbeta1 signal axis.	Hypochlorous Acid	0-12	interleukin 1 alpha	Homo sapiens	84-91
32661265-6	2020	We also demonstrated in vitro using human mesothelial cells that hypochlorite-induced fibrosis was likely due to necrosis, but not programmed apoptosis; besides, overexpression of IL1beta, CX3CL1 and TGFbeta on the peritoneal mesothelium in current model was detected, similar to observations from peritoneal dialysis-induced peritoneal fibrosis in human patients and earlier reported mouse model.	Hypochlorous Acid	65-77	interleukin 1 alpha	Homo sapiens	180-187
32650532-4	2020	Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D.	Cholesterol	101-112	interleukin 1 alpha	Homo sapiens	178-186
32650532-4	2020	Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D.	Uric Acid	114-119	interleukin 1 alpha	Homo sapiens	178-186
32650532-4	2020	Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D.	Glucose	125-132	interleukin 1 alpha	Homo sapiens	178-186
32733443-0	2020	Glucose Induces IL-1alpha-Dependent Inflammation and Extracellular Matrix Proteins Expression and Deposition in Renal Tubular Epithelial Cells in Diabetic Kidney Disease.	Glucose	0-7	interleukin 1 alpha	Homo sapiens	16-25
32733443-4	2020	Human proximal tubular kidney HK-2 cells exposed to high glucose (HG) gradually increase the expression of IL-1alpha but not IL-1beta and induce the expression and deposition of extracellular matrix (ECM) proteins.	Glucose	57-64	interleukin 1 alpha	Homo sapiens	107-116
32733443-5	2020	We further demonstrate that in vitro ectopic addition of recombinant IL-1alpha in low glucose concentration leads to a similar effect as in HG, while supplementing excess amounts of IL-1Ra in HG significantly attenuates the ECM protein overexpression and deposition.	Glucose	86-93	interleukin 1 alpha	Homo sapiens	69-78
32630207-5	2020	Here, we showed that ATRA prolongs the expression of IL-6 and IL-1beta following a 2-, 6-, 12-, and 24-h LPS (100ng/mL) activation in human monocyte-derived macrophages.	Tretinoin	21-25	interleukin 1 alpha	Homo sapiens	62-70
32350565-11	2020	GPR44 inhibition antagonised the reduction in glucose-stimulated insulin secretion induced by HG and IL-1beta in human islets.	Glucose	46-53	interleukin 1 alpha	Homo sapiens	101-109
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 1 alpha	Homo sapiens	165-173
32447451-5	2020	RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 alpha	Homo sapiens	106-114
32447451-9	2020	CONCLUSIONS: Actovegin  can reduce the PMA-induced IL-1beta release and the ROS production from PBMCs.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	51-59
32537016-6	2020	In vitro, the results demonstrated that baicalin clearly inhibited the release of TNF-alpha, IL-6 and IL-1beta and promoted the expression of IL-10 in LPS-induced HT-29 cells, and significantly decreased LPS-induced HT-29 cell apoptosis by blockage of the PI3K/AKT signaling pathway.	baicalin	40-48	interleukin 1 alpha	Homo sapiens	102-110
32347316-6	2020	RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis).	Hydrogen Peroxide	31-35	interleukin 1 alpha	Homo sapiens	183-205
32973818-8	2020	The interesting and evolving potential of phosphoinositide 3-kinase delta (PI3Kdelta) inhibitors, together with Ebastine, lies in their ability to suppress the release of pro-inflammatory cytokines, such as IL-1beta, IL-8, IL-6, and TNF-alpha, by T cells.	ebastine	112-120	interleukin 1 alpha	Homo sapiens	207-215
32707731-6	2020	Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion.	Oxygen	163-169	interleukin 1 alpha	Homo sapiens	234-242
32944181-8	2020	Moreover, LEV treatment significantly induced expression of macrophage-characteristic cytokines, IL-1beta, GM-CSF and the representative anti-inflammatory cytokine, IL-10, in human skin organ cultures.	lenvatinib	10-13	interleukin 1 alpha	Homo sapiens	97-105
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	interleukin 1 alpha	Homo sapiens	81-89
31036393-11	2020	CONCLUSION: Plant derived essential oils and related active compounds have potential therapeutic activity for the treatment of asthma by modulating the release of pro-inflammatory (TNF-alpha, IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10), Th1 (IFN-gamma, IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines and the suppression of inflammatory cell accumulation.	Oils, Volatile	26-40	interleukin 1 alpha	Homo sapiens	192-200
32669704-7	2020	In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-alpha, IL-6 and IL-1beta via the ROS-PPARgamma-NF-kappaB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 production.	ala-sdt	10-17	interleukin 1 alpha	Homo sapiens	79-87
32601180-3	2020	We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1beta and CXCL8.	Peptides	22-29	interleukin 1 alpha	Homo sapiens	181-189
32420725-3	2020	Our data indicated that IL-1beta alone does not inhibit HCV replication, yet when in combination with IFN-alpha, it can boost anti-HCV activity of IFN-alpha, which is mediated by augmented STAT1 tyrosine 701 phosphorylation.	Tyrosine	195-203	interleukin 1 alpha	Homo sapiens	24-32
32420725-5	2020	Our study found that IL-1beta negatively affects ERK2 phosphorylation, which suggests that IL-1beta mediated STAT1 tyrosine 701 phosphorylation employed kinase machinery of ERK2 other than JNK or P38 kinase.	Tyrosine	115-123	interleukin 1 alpha	Homo sapiens	21-29
32420725-5	2020	Our study found that IL-1beta negatively affects ERK2 phosphorylation, which suggests that IL-1beta mediated STAT1 tyrosine 701 phosphorylation employed kinase machinery of ERK2 other than JNK or P38 kinase.	Tyrosine	115-123	interleukin 1 alpha	Homo sapiens	91-99
32733481-15	2020	To explain morphine-induced persistent sensitization, a positive feedback loop has been proposed; this involves an initial morphine-induced amplified release of IL-1beta and a subsequent exacerbated release of DAMPs, which increases the activation of TLR4 and the purinergic receptor P2X7R.	Morphine	11-19	interleukin 1 alpha	Homo sapiens	161-169
32733481-15	2020	To explain morphine-induced persistent sensitization, a positive feedback loop has been proposed; this involves an initial morphine-induced amplified release of IL-1beta and a subsequent exacerbated release of DAMPs, which increases the activation of TLR4 and the purinergic receptor P2X7R.	Morphine	123-131	interleukin 1 alpha	Homo sapiens	161-169
32753846-6	2020	Results: Baicalin treatment decreased the apoptosis rate and the expressions of pro-apoptotic proteins induced by IL-1beta, up-regulated anti-apoptotic Bcl-2 expression, and inhibited the degradation of ECM.	baicalin	9-17	interleukin 1 alpha	Homo sapiens	114-122
32753846-9	2020	Furthermore, the differential expressional profiles of miR-766-3p and apoptosis-inducing factor mitochondria-associated 1 (AIFM1) were determined in IL-1beta and IL-1beta + baicalin-treated chondrocytes, and we confirmed AIFM1 was a target of miR-766-3p.	baicalin	173-181	interleukin 1 alpha	Homo sapiens	162-170
32753846-12	2020	Conclusion: Baicalin protects human OA chondrocytes against IL-1beta-induced apoptosis and the degradation of ECM through activating autophagy via miR-766-3p/AIFM1 axis and serves as a potential therapeutic candidate for OA treatment.	baicalin	12-20	interleukin 1 alpha	Homo sapiens	60-68
32630814-1	2020	Recent studies suggested an important contribution of sphingosine-1-phospate (S1P) signaling via its specific receptors (S1PRs) in the production of pro-inflammatory mediators such as Interleukin (IL)-1beta in cancer and inflammation.	sphingosine-1-phospate	54-76	interleukin 1 alpha	Homo sapiens	184-206
32835592-10	2020	The IL-1beta-mediated upregulation of occludin was prevented by the NF-kappaB inhibitor BAY 11-7085.	BAY 11-7085	88-99	interleukin 1 alpha	Homo sapiens	4-12
32134203-11	2020	Furthermore, beta-carotene reduced IL-1beta secretion from human synovial fluid cells isolated from gout patients (p<0.05), showing its inhibitory efficacy in human patient cells.	beta Carotene	13-26	interleukin 1 alpha	Homo sapiens	35-43
32440348-2	2020	The combined effect of Cit, GlcN and GlcNAc on synovial cell inflammation was assessed by measuring IL-1beta-induced IL-6 production.	Acetylglucosamine	37-43	interleukin 1 alpha	Homo sapiens	100-108
32194233-5	2020	We demonstrated that dexamethasone in vitro given for 24 hours and followed by a 24-hour rest interval before an immune challenge potentiates inflammatory effects in these neural cells, that is, increases the IL-6 protein secretion induced by stimulation with IL-1beta (10ng/mL for 24 hours) by +49% (P<0.05) at a concentration of 100nM and by +70% (P<0.01) for 1muM.	Dexamethasone	21-34	interleukin 1 alpha	Homo sapiens	260-268
32315958-8	2020	RESULTS: Following butyrate supplementation, the relative expression levels of TLR2/4, NF-kappaB1, Caspase-1, NLRP3, IL-1beta & IL-18 were significantly downregulated (p < 0.05).	Butyrates	19-27	interleukin 1 alpha	Homo sapiens	117-125
32171072-9	2020	In conclusion, our findings demonstrate that TNF-alpha and IL-1beta act critical roles in type B trichothecenes-induced anorexic response.	Trichothecenes	97-111	interleukin 1 alpha	Homo sapiens	59-67
32361974-5	2020	The presence of NAC antagonized the ROS production, expressions of IRE1alpha and p-IRE1alpha; however, STF-083010 could decrease the expression levels of GRP78, XBP1, NF-kappaB, and p-NF-kappaB and attenuate IL-1beta, IL-6, TNF-alpha, VCAM-1, and ET-1 release induced by endosulfan.	Acetylcysteine	16-19	interleukin 1 alpha	Homo sapiens	208-216
32537016-5	2020	In the present study, the results revealed that baicalin not only significantly alleviated TNBS-induced colitis by reducing the release of IL-6, TNF-alpha and IL-1beta and increasing the level of IL-10, but promoted the expression of tight-junction proteins ZO-1 and beta-catenin, which may have been achieved by blockage of the PI3K/AKT signaling pathway.	baicalin	48-56	interleukin 1 alpha	Homo sapiens	159-167
32298238-5	2020	The inflammatory cytokine IL-1beta reduced cAMP generation and CREB-mediated transcription of VE-cadherin.	Cyclic AMP	43-47	interleukin 1 alpha	Homo sapiens	26-34
32558310-2	2020	We also evaluate the quality of life and school attendance among colchicine-resistant FMF patients, in relation to treatment with anti-IL-1.	Colchicine	65-75	interleukin 1 alpha	Homo sapiens	135-139
32558310-5	2020	Anti-IL-1 treatment is promising in colchicine-resistant patients due to excessive IL-1beta production in pathogenesis.	Colchicine	36-46	interleukin 1 alpha	Homo sapiens	5-9
32558310-5	2020	Anti-IL-1 treatment is promising in colchicine-resistant patients due to excessive IL-1beta production in pathogenesis.	Colchicine	36-46	interleukin 1 alpha	Homo sapiens	83-91
32558310-6	2020	The aim of this study is to evaluate the quality of life and school attendance rates among colchicine-resistant FMF patients after anti-IL-1 treatment.	Colchicine	91-101	interleukin 1 alpha	Homo sapiens	136-140
32558310-7	2020	METHODS: This is a single center retrospective study of 25 pediatric colchicine-resistant FMF patients treated with anti-IL-1 treatment.	Colchicine	69-79	interleukin 1 alpha	Homo sapiens	121-125
32558310-14	2020	CONCLUSION: Anti-IL-1 treatment is quite effective in children with colchicine-resistant FMF patients, proven with improved AIDAI scores and school attendance rates.	Colchicine	68-78	interleukin 1 alpha	Homo sapiens	17-21
32398478-1	2020	Interleukin-1 (IL-1) receptor antagonist (anakinra) has been shown to be effective in steroid-dependent recurrent pericarditis resistant to nonsteroidal anti-inflammatory drugs (NSAIDs) and colchicine.	Steroids	86-93	interleukin 1 alpha	Homo sapiens	0-13
32398478-1	2020	Interleukin-1 (IL-1) receptor antagonist (anakinra) has been shown to be effective in steroid-dependent recurrent pericarditis resistant to nonsteroidal anti-inflammatory drugs (NSAIDs) and colchicine.	Colchicine	190-200	interleukin 1 alpha	Homo sapiens	0-13
32181981-0	2020	Resveratrol counteracts IL-1beta-mediated impairment of extracellular matrix deposition in 3D articular chondrocyte constructs.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	24-32
32202959-3	2020	Recently, glyburide, a hypoglycemic sulfonylurea, has been reported to reduce IL-1beta activation by suppressing activation of the NLRP3 inflammasome.	Glyburide	10-19	interleukin 1 alpha	Homo sapiens	78-86
32202959-3	2020	Recently, glyburide, a hypoglycemic sulfonylurea, has been reported to reduce IL-1beta activation by suppressing activation of the NLRP3 inflammasome.	Sulfonylurea Compounds	36-48	interleukin 1 alpha	Homo sapiens	78-86
32202959-7	2020	Stimulation of THP-1 macrophage-like cells with every periodontopathic bacteria induced IL-1beta secretion without cell death, which was suppressed by the NLRP3 inhibitor, MCC950, and caspase-1 inhibitor, z-YVAD-FMK.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	205-215	interleukin 1 alpha	Homo sapiens	88-96
32202959-8	2020	Glyburide treatment suppressed IL-1beta expression in culture supernatants and enhanced intracellular IL-1beta expression, suggesting that glyburide may have inhibited IL-1beta secretion.	Glyburide	0-9	interleukin 1 alpha	Homo sapiens	31-39
32202959-8	2020	Glyburide treatment suppressed IL-1beta expression in culture supernatants and enhanced intracellular IL-1beta expression, suggesting that glyburide may have inhibited IL-1beta secretion.	Glyburide	0-9	interleukin 1 alpha	Homo sapiens	102-110
32202959-8	2020	Glyburide treatment suppressed IL-1beta expression in culture supernatants and enhanced intracellular IL-1beta expression, suggesting that glyburide may have inhibited IL-1beta secretion.	Glyburide	0-9	interleukin 1 alpha	Homo sapiens	102-110
32202959-11	2020	In addition to glyburide, glimepiride was shown to suppress the release of IL-1beta from THP-1 macrophage-like cells, whereas other sulfonylureas (tolbutamide and gliclazide) or other hypoglycemic drugs belonging to the biguanide family, such as metformin, failed to suppress IL-1beta release.	glimepiride	26-37	interleukin 1 alpha	Homo sapiens	75-83
32202959-11	2020	In addition to glyburide, glimepiride was shown to suppress the release of IL-1beta from THP-1 macrophage-like cells, whereas other sulfonylureas (tolbutamide and gliclazide) or other hypoglycemic drugs belonging to the biguanide family, such as metformin, failed to suppress IL-1beta release.	glimepiride	26-37	interleukin 1 alpha	Homo sapiens	276-284
32181981-7	2020	Culture with IL-1beta (10 ng/ml) decreased pellet size and DNA amount, and severely compromised glycosaminoglycan (GAG) and collagen content.	Glycosaminoglycans	96-113	interleukin 1 alpha	Homo sapiens	13-21
32181981-7	2020	Culture with IL-1beta (10 ng/ml) decreased pellet size and DNA amount, and severely compromised glycosaminoglycan (GAG) and collagen content.	Glycosaminoglycans	115-118	interleukin 1 alpha	Homo sapiens	13-21
32181981-11	2020	In conclusion, RSV can counteract IL-1beta-mediated degradation and distinctly improve cartilaginous ECM deposition in 3D long-term inflammatory cultures.	Resveratrol	15-18	interleukin 1 alpha	Homo sapiens	34-42
32367036-7	2020	Disulfiram still allows IL-1beta and GSDMD processing, but abrogates pore formation, thereby preventing IL-1beta release and pyroptosis.	Disulfiram	0-10	interleukin 1 alpha	Homo sapiens	24-32
32367036-7	2020	Disulfiram still allows IL-1beta and GSDMD processing, but abrogates pore formation, thereby preventing IL-1beta release and pyroptosis.	Disulfiram	0-10	interleukin 1 alpha	Homo sapiens	104-112
32323100-8	2020	We found that co-treatment with LPS and ATP increased the secretion of IL-1beta and expression of NLRP3 in HPDLFs, while TRIM31 overexpression could reverse these effects caused by LPS and ATP.	Adenosine Triphosphate	40-43	interleukin 1 alpha	Homo sapiens	71-79
32413745-9	2020	Concordantly, we observed a significantly elevated level of serum IL-1beta, which indicates an increase of NLRP3 inflammasome activity associated with the reduced level of serum melatonin, in heroin-addicted patients relative to healthy individuals.	Melatonin	178-187	interleukin 1 alpha	Homo sapiens	66-74
32413745-9	2020	Concordantly, we observed a significantly elevated level of serum IL-1beta, which indicates an increase of NLRP3 inflammasome activity associated with the reduced level of serum melatonin, in heroin-addicted patients relative to healthy individuals.	Heroin	192-198	interleukin 1 alpha	Homo sapiens	66-74
32855848-6	2020	Results: Treatment with 3TC markedly reduced Alu RNA-induced expression of IL-18 and IL-1beta in human and mouse RPE cells compared with the negative control.	Lamivudine	24-27	interleukin 1 alpha	Homo sapiens	85-93
32347316-6	2020	RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis).	Hydrogen Peroxide	12-29	interleukin 1 alpha	Homo sapiens	183-205
32054994-12	2020	Enhanced expression of TNF and the activation of NLRP3 and CASP1 followed by the increased generation of IL-1beta and nuclear translocation of the NF-kappabeta transcription factor occurred in response to hemoglobin-derived peptides, and ferryl hemoglobin in endothelium was upregulated in both pathologies.	ferryl iron	238-244	interleukin 1 alpha	Homo sapiens	105-113
32694786-7	2020	This correlates with their immunosuppressive phenotype: dimethyl itaconate and 4-octyl itaconate inhibited IkappaBzeta and pro-interleukin (IL)-1beta induction, as well as IL-6, IL-10 and interferon-beta secretion, in an NRF2-independent manner.	dimethyl itaconate	56-74	interleukin 1 alpha	Homo sapiens	123-149
32694786-7	2020	This correlates with their immunosuppressive phenotype: dimethyl itaconate and 4-octyl itaconate inhibited IkappaBzeta and pro-interleukin (IL)-1beta induction, as well as IL-6, IL-10 and interferon-beta secretion, in an NRF2-independent manner.	4-Octyl Itaconate	79-96	interleukin 1 alpha	Homo sapiens	123-149
32694786-8	2020	In contrast, itaconate treatment suppressed IL-1beta secretion but not pro-IL-1beta levels and, surprisingly, strongly enhanced lipopolysaccharide-induced interferon-beta secretion.	itaconic acid	13-22	interleukin 1 alpha	Homo sapiens	44-52
32616234-6	2020	After 7-D ammonia exposure, the proportion of the phylum Proteobacteria and the genus Escherichia/Shigella in lung tissue was significantly increased, the expression levels of NLRP3 and caspase-1 mRNA were significantly increased, and the content of IL-1beta in lung tissue and serum was higher than that in the control group.	Ammonia	10-17	interleukin 1 alpha	Homo sapiens	250-258
32616234-7	2020	In conclusion, high ammonia induced lung tissue inflammation via increasing the proportion of Escherichia/Shigella, activating NLRP3 inflammasome, and promoting IL-1beta release.	Ammonia	20-27	interleukin 1 alpha	Homo sapiens	161-169
32321163-5	2020	These investigations revealed rapid caspase-1 activation and mature IL-1beta secretion in the skin and draining lymph nodes (dLNs) after 1.5 and 3% triclosan exposure.	Triclosan	148-157	interleukin 1 alpha	Homo sapiens	68-76
32726040-5	2020	The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin.	Chlorogenic Acid	55-71	interleukin 1 alpha	Homo sapiens	151-155
32714980-8	2020	Mechanically, CD147 promoted phosphorylation of NF-kappaB p65 in IECs, while inhibition of NF-kappaB activity by the NF-kappaB inhibitor BAY11-7082 reversed the effect of CD147 on IL-1beta and IL-18 secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	137-147	interleukin 1 alpha	Homo sapiens	180-188
32726040-5	2020	The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin.	Chlorogenic Acid	178-194	interleukin 1 alpha	Homo sapiens	151-155
32726040-5	2020	The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin.	linalool	199-207	interleukin 1 alpha	Homo sapiens	151-155
32726040-5	2020	The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin.	Chlorogenic Acid	178-194	interleukin 1 alpha	Homo sapiens	151-155
32726040-6	2020	It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin.	lonicerae japonicae	51-70	interleukin 1 alpha	Homo sapiens	125-129
32726040-6	2020	It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin.	Chlorogenic Acid	153-169	interleukin 1 alpha	Homo sapiens	125-129
32602358-3	2021	This study aimed to investigate how inhibition of HMGB1 by glycyrrhizin might affect inflammatory responses and viability of OA patient-derived chondrocytes treated with IL-1beta.	Glycyrrhizic Acid	59-71	interleukin 1 alpha	Homo sapiens	170-178
32726040-6	2020	It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin.	linalool	174-182	interleukin 1 alpha	Homo sapiens	125-129
32726040-6	2020	It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin.	lonicerae	51-60	interleukin 1 alpha	Homo sapiens	125-129
32602358-6	2021	The impact of glycyrrhizin on IL-1beta-induced cell toxicity and inflammatory mediators and cytokines, including prostaglandin E2 (PGE2), nitric oxide (NO), proinflammatory cytokines, and metalloproteases (MMPs), were assessed by ELISA, Western blot, quantitative real-time polymerase chain reaction, and the Griess reagent assay.	Glycyrrhizic Acid	14-26	interleukin 1 alpha	Homo sapiens	30-38
32602358-8	2021	HMGB1 inhibition by glycyrrhizin improved cell viability of chondrocytes treated with IL-1beta.	Glycyrrhizic Acid	20-32	interleukin 1 alpha	Homo sapiens	86-94
32610117-0	2020	The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation.	Leucine	4-11	interleukin 1 alpha	Homo sapiens	52-56
32602358-9	2021	Glycyrrhizin suppressed IL-1beta-induced upregulation of HMGB1 and inflammatory mediators and cytokines, including PGE2, NO, proinflammatory cytokines, and MMPs.	Glycyrrhizic Acid	0-12	interleukin 1 alpha	Homo sapiens	24-32
32602358-9	2021	Glycyrrhizin suppressed IL-1beta-induced upregulation of HMGB1 and inflammatory mediators and cytokines, including PGE2, NO, proinflammatory cytokines, and MMPs.	Dinoprostone	115-119	interleukin 1 alpha	Homo sapiens	24-32
32629886-6	2020	Interestingly, the secretion of interleukin-1 beta (IL-1beta) was only modestly impacted by NaHS exposure despite a significant accumulation of IL-1beta pro-form.	sodium bisulfide	92-96	interleukin 1 alpha	Homo sapiens	52-60
32484349-5	2020	Ouratein D (4) inhibited in vitro the release of the pro-inflammatory cytokine CCL2 by lipopolysaccharide-stimulated THP-1 cells (IC50 of 3.1 +- 1.1 muM), whereas TNF and IL-1beta release were not reduced by any of the biflavanones.	ouratein d	0-10	interleukin 1 alpha	Homo sapiens	171-179
32630037-8	2020	Finally, caffeic acid ethyl ester and comfreyn A were found to significantly inhibit E-selectin expression in IL-1beta stimulated human umbilical vein endothelial cells (HUVEC), with EC values of 64 and 50 microM, respectively.	ethyl caffeate	9-33	interleukin 1 alpha	Homo sapiens	110-118
32630037-8	2020	Finally, caffeic acid ethyl ester and comfreyn A were found to significantly inhibit E-selectin expression in IL-1beta stimulated human umbilical vein endothelial cells (HUVEC), with EC values of 64 and 50 microM, respectively.	comfreyn a	38-48	interleukin 1 alpha	Homo sapiens	110-118
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	interleukin 1 alpha	Homo sapiens	176-184
32432601-0	2020	Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway.	ros	72-75	interleukin 1 alpha	Homo sapiens	82-90
32561825-4	2020	Surprisingly, we observed that the greater decreases in glucose level were associated to increased IL-1beta serum levels (p = 0.040).	Glucose	56-63	interleukin 1 alpha	Homo sapiens	99-107
32684834-8	2020	In addition, SDG increased NO release and decreased the levels of IL-1beta, IL-6, and TNF-alpha in LPS-treated HUVECs.	secoisolariciresinol diglucoside	13-16	interleukin 1 alpha	Homo sapiens	66-74
32472783-9	2020	The recurrence rate induced by recombinant human IL-1beta in Sal B-treated group was significantly lower than that in SASP-treated group.	salvianolic acid B	61-66	interleukin 1 alpha	Homo sapiens	49-57
32575582-0	2020	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1beta and NF-kappaB Proteins.	piperine	40-48	interleukin 1 alpha	Homo sapiens	137-145
32575582-0	2020	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1beta and NF-kappaB Proteins.	piperlonguminine	54-68	interleukin 1 alpha	Homo sapiens	137-145
32561825-2	2020	At basal time, the T polymorphic allele of the rs16944 was associated with lower IL-1beta mRNA expression (p = 0.006); and higher glucose level was positive correlated to IL-1beta protein levels (p = 0.015).	Glucose	130-137	interleukin 1 alpha	Homo sapiens	171-179
32546242-18	2020	CONCLUSIONS: We describe two cases of failure of the treatment with anti-IL-1beta monoclonal antibodies in steroid- dependent idiopathic RP.	Steroids	107-114	interleukin 1 alpha	Homo sapiens	73-81
32412019-4	2020	The most effective PBAE identified enhanced DEX uptake by 8 folds compared to an equivalent dose of the commercial formulation and also prevented, through delivery of DEX, the cartilage degradation caused by IL-1alpha (interleukine1alpha).	Dexamethasone	167-170	interleukin 1 alpha	Homo sapiens	208-217
32549383-5	2020	In the aPL+ group, E2 presence markedly increased the percentage of NK cells positive for CD69 (p < 0.05), monocytes positive for tissue factor (TF, CD142) (p < 0.05), and B cells expressing PD-L1 (p < 0.05), as well as the elevated production of IL-1beta comparing to aPL- women (p < 0.01).	Estradiol	19-21	interleukin 1 alpha	Homo sapiens	247-255
32587797-11	2020	Moreover, the highest ROS and the lowest insulin secretion were found in FAC combined with IL-1beta and TNF-alpha in the high-glucose condition of human pancreatic beta cell, which could be involved in the mechanism of DM development in beta-thalassemia patients.	Reactive Oxygen Species	22-25	interleukin 1 alpha	Homo sapiens	91-99
32587797-11	2020	Moreover, the highest ROS and the lowest insulin secretion were found in FAC combined with IL-1beta and TNF-alpha in the high-glucose condition of human pancreatic beta cell, which could be involved in the mechanism of DM development in beta-thalassemia patients.	Glucose	126-133	interleukin 1 alpha	Homo sapiens	91-99
32539713-8	2020	However, the inhibitory effects of baricitinib on IL-1beta production were larger compared to those of tofacitinib or upadacitinib at lower concentrations (<= 100 nM).	baricitinib	35-46	interleukin 1 alpha	Homo sapiens	50-58
32655829-6	2020	Plasma IL-1beta, TNF-alpha and IL-4 levels were higher in the ACG than in the BCG (Z = -3.089, -2.458 and -1.987; P = 0.002, 0.014, and 0.047; respectively).	acg	62-65	interleukin 1 alpha	Homo sapiens	7-15
32165203-8	2020	In our research, the experiments were carried out incubating the cells with glucans for 18 h in culture medium containing 0.2% FBS and measuring ROS levels fluorimetrically as dihydrodichlorofluoresce diacetate (DCF-DA) fluorescence, protein levels of DUOX-2 by Western blotting and mRNA levels of, TNF-alpha, IL-1beta and COX-2 by qRT-PCR.	Glucans	76-83	interleukin 1 alpha	Homo sapiens	310-318
32165203-10	2020	The expression levels of COX-2, TNF-alpha, and IL-1beta were also reduced by alpha- and beta-glucans.	alpha- and beta-glucans	77-100	interleukin 1 alpha	Homo sapiens	47-55
32165203-14	2020	The treatment of cells with the NADPH oxidase (NOX) inhibitor apocynin decrease ROS, DUOX-2, COX-2, TNF-alpha and IL-1beta levels indicating that NOX dependent ROS regulate the expression of immune modulating factors of intestinal cells.	Reactive Oxygen Species	160-163	interleukin 1 alpha	Homo sapiens	114-122
32101829-3	2020	Previously, we reported that PA stimulated IL-1beta secretion via activation of NLRP3 inflammasome in human placental cells.	Palmitic Acid	29-31	interleukin 1 alpha	Homo sapiens	43-51
32545869-6	2020	Partial ablation of the Arg/N-degron pathway greatly increases IL-1beta secretion, indicating the importance of this ubiquitous pathway in the initiation and resolution of inflammation.	Arginine	24-27	interleukin 1 alpha	Homo sapiens	63-71
32545869-6	2020	Partial ablation of the Arg/N-degron pathway greatly increases IL-1beta secretion, indicating the importance of this ubiquitous pathway in the initiation and resolution of inflammation.	Nitrogen	28-29	interleukin 1 alpha	Homo sapiens	63-71
32595496-5	2020	SB216763 and Nec-1 also decreased levels of inflammatory related cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha).	SB 216763	0-8	interleukin 1 alpha	Homo sapiens	128-136
32595496-7	2020	Concurrent neutralization of TNF-alpha, IL-1beta, and IL-6 with their antibodies provided better reduction in oxygen and glucose deprivation-induced increases in scar markers than obtained with separate use of each antibody.	Oxygen	110-116	interleukin 1 alpha	Homo sapiens	40-48
32503178-6	2020	Fermentation of media supplemented with native and enzyme-treated oat beta-glucans increased the relative abundance of Enterococcus and attenuated pro-inflammatory cytokine production (IL-1beta, IL-6, TNFalpha) in immature dendritic cells.	beta-Glucans	70-82	interleukin 1 alpha	Homo sapiens	185-193
32526964-7	2020	The BaP-induced IL1A and IL1B was also downregulated by BAI.	Benzo(a)pyrene	4-7	interleukin 1 alpha	Homo sapiens	16-20
32582195-6	2020	A mechanistic study revealed that S. sonnei induced IL-1beta production through P2X7 receptor-mediated potassium efflux, reactive oxygen species generation, lysosomal acidification, and mitochondrial damage.	Potassium	103-112	interleukin 1 alpha	Homo sapiens	52-60
32582195-6	2020	A mechanistic study revealed that S. sonnei induced IL-1beta production through P2X7 receptor-mediated potassium efflux, reactive oxygen species generation, lysosomal acidification, and mitochondrial damage.	reactive	121-129	interleukin 1 alpha	Homo sapiens	52-60
32582195-6	2020	A mechanistic study revealed that S. sonnei induced IL-1beta production through P2X7 receptor-mediated potassium efflux, reactive oxygen species generation, lysosomal acidification, and mitochondrial damage.	oxygen species	130-144	interleukin 1 alpha	Homo sapiens	52-60
32582751-2	2020	Among the phytonutrients, epidemiological and experimental studies show that dietary organosulfur compounds (OSC) play a significant role in preventing various human pathological progressions, including chronic inflammation, by decreasing inflammatory mediators such as nitric oxide (NO), prostaglandin (PG)E2, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-17, which are all typical hallmarks of inflammation.	organosulfur compounds	85-107	interleukin 1 alpha	Homo sapiens	311-333
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	interleukin 1 alpha	Homo sapiens	108-116
32199223-6	2020	Pretreatment of THP-1 monocytes with DHA effectively inhibited Abeta-induced activation and markedly suppressed protein expression of necroptosis (RIPK1, RIPK3, MLKL) and pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6).	Docosahexaenoic Acids	37-40	interleukin 1 alpha	Homo sapiens	210-218
32028854-2	2020	Biological function experiments showed that miR-218 and inflammatory factors TNF-alpha and IL-1beta were highly expressed in renal proximal tubule under high-glucose conditions.	Glucose	158-165	interleukin 1 alpha	Homo sapiens	91-99
32241426-6	2020	Dox:CS/CMCS-NPs effectively down-regulated both gene and protein levels of NLRP3 inflammasome and IL-1beta in HGFs.	Doxycycline	0-3	interleukin 1 alpha	Homo sapiens	98-106
32022249-10	2020	The suppression of P2X7R activation by 2354glu administration inhibited IL-1beta release, and reduced macrophage and neutrophil infiltration.	seclazone	39-46	interleukin 1 alpha	Homo sapiens	72-80
32022249-11	2020	The expression of P2X7R, caspase-1 and NF-kappaB, the release of IL-1beta, calcium influx and PI uptake were reduced by 2354glu in macrophages stimulated with LPS/ATP.	seclazone	120-127	interleukin 1 alpha	Homo sapiens	65-73
32259365-3	2020	We demonstrated that M2 macrophages produce interleukin 1beta (IL-1beta), which activates phosphorylation of the glycolytic enzyme glycerol-3-phosphate dehydrogenase (GPD2) at threonine 10 (GPD2 pT10) through phosphatidylinositol-3-kinase-mediated activation of protein kinase-delta (PKCdelta) in glioma cells.	Threonine	176-185	interleukin 1 alpha	Homo sapiens	63-71
32199215-3	2020	Our study showed that treating human bronchial epithelial (16HBE) cells with neodymium oxide caused an inflammatory response by upregulating the expression of interleukin-8 (IL-8) and interleukin-1 beta (IL-1beta).	neodymium oxide	77-92	interleukin 1 alpha	Homo sapiens	204-212
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	circ_0000638	10-22	interleukin 1 alpha	Homo sapiens	58-66
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	neodymium oxide	105-120	interleukin 1 alpha	Homo sapiens	58-66
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	16hbe	129-134	interleukin 1 alpha	Homo sapiens	58-66
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	circ_0000638	27-39	interleukin 1 alpha	Homo sapiens	163-171
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	neodymium oxide	175-190	interleukin 1 alpha	Homo sapiens	163-171
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	interleukin 1 alpha	Homo sapiens	163-171
32615723-3	2020	We investigated inhibition of interleukin-1beta (IL-1beta)-induced EndMT by gemigliptin, a dipeptidyl peptidase-IV inhibitor.	LC15-0444	76-87	interleukin 1 alpha	Homo sapiens	49-57
32615723-5	2020	RESULTS: Morphological changes showed gemigliptin blocked IL-1beta-induced EndMT, upregulated EC markers, and downregulated smooth muscle and mesenchymal markers.	LC15-0444	38-49	interleukin 1 alpha	Homo sapiens	58-66
32289583-12	2020	The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression.	Polycyclic Aromatic Hydrocarbons	25-28	interleukin 1 alpha	Homo sapiens	42-50
32615723-8	2020	Reversal of IL-1beta-mediated inhibition of BMP-induced Smad1/5/8, Smad2, and Smad3 phosphorylation by gemigliptin suggests involvement of the Smad pathway in gemigliptin action.	LC15-0444	159-170	interleukin 1 alpha	Homo sapiens	12-20
32615723-9	2020	In the non-Smad BMP pathway, gemigliptin treatment significantly increased the deactivation of extracellular regulated protein kinase (ERK), p38, and JNK by IL-1beta.	LC15-0444	29-40	interleukin 1 alpha	Homo sapiens	157-165
32615723-7	2020	Gemigliptin inhibited IL-1beta induction of BMP2 and 7, activin receptor type IA, BMP receptor type IA, and BMP receptor type II.	LC15-0444	0-11	interleukin 1 alpha	Homo sapiens	22-30
32615723-10	2020	Gemigliptin treatment suppressed BMP-2-induced expression of key osteoblastic markers including osterix, runt-related transcription factor 2, and hepcidin during IL-1beta-induced EndMT.	LC15-0444	0-11	interleukin 1 alpha	Homo sapiens	162-170
32615723-8	2020	Reversal of IL-1beta-mediated inhibition of BMP-induced Smad1/5/8, Smad2, and Smad3 phosphorylation by gemigliptin suggests involvement of the Smad pathway in gemigliptin action.	LC15-0444	103-114	interleukin 1 alpha	Homo sapiens	12-20
32615723-11	2020	CONCLUSION: We demonstrated a novel protective mechanism of gemigliptin against fibrosis by suppressing IL-1beta-induced EndMT.	LC15-0444	60-71	interleukin 1 alpha	Homo sapiens	104-112
32275191-3	2020	Based on experimental data, we hypothesized an effect of IL-1 antagonism via modulation of the renin-angiotensin-aldosterone system.	Aldosterone	113-124	interleukin 1 alpha	Homo sapiens	57-61
32692251-10	2020	RESULTS: Seventeen out of 30 MeONPs induced excess IL-1beta production in THP-1 cells.	meonps	29-35	interleukin 1 alpha	Homo sapiens	51-59
32841189-13	2020	There was a significant decrease in uric acid concentration, pro- (IL-1beta, TNF-alpha) and anti-inflammatory cytokine (IL-10) content after treatment in both groups, but more in patients who received carbon enterosorbent with basic therapy.	Carbon	201-207	interleukin 1 alpha	Homo sapiens	67-75
32249647-7	2020	Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18).	laquinimod	14-24	interleukin 1 alpha	Homo sapiens	81-89
32249647-7	2020	Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18).	mangion-purified polysaccharide (Candida albicans)	35-39	interleukin 1 alpha	Homo sapiens	81-89
32172204-6	2020	Melatonin-treated HUVECs showed a decrease of pro-inflammatory mRNAs [interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha)] under the stimulation of SLE medium.	Melatonin	0-9	interleukin 1 alpha	Homo sapiens	89-97
32179246-0	2020	Alogliptin inhibits IL-1beta-induced inflammatory response in fibroblast-like synoviocytes.	alogliptin	0-10	interleukin 1 alpha	Homo sapiens	20-28
32328683-0	2020	MiR-146a-5p promotes IL-1beta-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway.	mir-146a-5p	0-11	interleukin 1 alpha	Homo sapiens	21-29
32179246-3	2020	In the present study, we aimed to investigate whether alogliptin possessed a protective effect against IL-1beta-induced insult in FLS.	alogliptin	54-64	interleukin 1 alpha	Homo sapiens	103-111
32179246-4	2020	Our results indicate that alogliptin treatment ameliorated IL-1beta-induced production of reactive oxygen species, the expression of matrix metalloproteinase-3 (MMP-3) and MMP-13, secretions of tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-8.	alogliptin	26-36	interleukin 1 alpha	Homo sapiens	59-67
32179246-4	2020	Our results indicate that alogliptin treatment ameliorated IL-1beta-induced production of reactive oxygen species, the expression of matrix metalloproteinase-3 (MMP-3) and MMP-13, secretions of tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-8.	Reactive Oxygen Species	90-113	interleukin 1 alpha	Homo sapiens	59-67
32179246-5	2020	Additionally, we found that alogliptin inhibited c-Jun N-terminal kinase (JNK)/activator protein 1 (AP-1) signaling by reducing IL-1beta-induced phosphorylation of JNK, the expression of c-Jun and c-Fos, and the luciferase activity of AP-1.	alogliptin	28-38	interleukin 1 alpha	Homo sapiens	128-136
32179246-6	2020	Importantly, alogliptin suppressed IL-1beta-induced activation of IkappaBalpha/NF-kappaB signaling by preventing the phosphorylation and degradation of IkappaBalpha, nuclear translocation of NF-kappaB p65, as well as the luciferase activity of AP-1.	alogliptin	13-23	interleukin 1 alpha	Homo sapiens	35-43
32251963-5	2020	OA-DHZ was found to inhibit the carrageenan-induced edema and leukocyte migration, acetic acid-induced increase in vascular permeability and lipopolysaccharide-induced pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta.	Acetic Acid	83-94	interleukin 1 alpha	Homo sapiens	221-229
32328683-8	2020	Compared with the control group, IL-1beta significantly decreased the viability of chondrocytes, while coculture with miR-146a-5p inhibitor rescued the IL-1beta-induced inhibition of chondrocyte viability.	mir-146a-5p	118-129	interleukin 1 alpha	Homo sapiens	152-160
31954113-1	2020	CRISPR-Cas9 engineered CYBBko THP-1 cell lines display an inflammatory profile with increased IL-1beta, IL-6 and TNF-alpha secretion as consequence of NADPH-induced ROS deficiency.	NADP	151-156	interleukin 1 alpha	Homo sapiens	94-102
32492823-3	2020	We found that IL-1beta plus TNF-alpha left-shifted the dye uptake rate vs. dye concentration relationship for Etd and 2-NBDG, but the opposite took place for DAPI or YO-PRO-1, whereas no alterations were observed for Prd.	etd	110-113	interleukin 1 alpha	Homo sapiens	14-22
32492823-3	2020	We found that IL-1beta plus TNF-alpha left-shifted the dye uptake rate vs. dye concentration relationship for Etd and 2-NBDG, but the opposite took place for DAPI or YO-PRO-1, whereas no alterations were observed for Prd.	2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose	118-124	interleukin 1 alpha	Homo sapiens	14-22
32492823-3	2020	We found that IL-1beta plus TNF-alpha left-shifted the dye uptake rate vs. dye concentration relationship for Etd and 2-NBDG, but the opposite took place for DAPI or YO-PRO-1, whereas no alterations were observed for Prd.	DAPI	158-162	interleukin 1 alpha	Homo sapiens	14-22
32064734-3	2020	The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF).	3-benzyl-6-chloro-2-pyrone	24-27	interleukin 1 alpha	Homo sapiens	189-193
32695290-13	2020	Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway.	Uric Acid	94-103	interleukin 1 alpha	Homo sapiens	26-34
32064734-3	2020	The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF).	beta-tricalcium phosphate	32-40	interleukin 1 alpha	Homo sapiens	189-193
32221603-8	2020	However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023).	Polyphenols	43-54	interleukin 1 alpha	Homo sapiens	223-227
32312847-2	2020	IL-1beta expression and release are tightly controlled by changes in intracellular Ca2+ ([Ca2+]i), which has been associated with ATP release and purinergic signaling.	Adenosine Triphosphate	130-133	interleukin 1 alpha	Homo sapiens	0-8
31802418-12	2020	Treatment with RK-33 inhibits the Tat and cocaine-dependent increase in the number and size of microglia and the proinflammatory cytokines IL-6, TNF-alpha, MCP-1/CCL2, MIP-2, IL-1alpha and IL-1beta.	Cocaine	42-49	interleukin 1 alpha	Homo sapiens	175-184
32378122-8	2020	We confirmed these beneficial effects in vitro, which indicated TPPU resulted in a significant improvement in IL-1beta-induced loss of BBB integrity on hCMEC/D3 cell monolayers.	TPPU	64-68	interleukin 1 alpha	Homo sapiens	110-118
32801436-8	2020	Inflammatory cytokine MCP-1 was remarkably decreased in both study groups but (heat shock protein 60 (HSP60), MCP-1 and interleukin-1beta (IL-1beta)) significantly decreased levels were observed among the TMZ-EECP group (P<0.05).	Trimetazidine	205-208	interleukin 1 alpha	Homo sapiens	139-147
32801436-10	2020	TMZ and EECP therapy in patients with stable refractory angina remarkably decreased the inflammatory markers HSP60, MCP-1 and IL-1beta in serum levels also the decreased levels were found in serum levels of oxidative stress marker 8-iso-PGF2beta serum level.	Trimetazidine	0-3	interleukin 1 alpha	Homo sapiens	126-134
32801436-10	2020	TMZ and EECP therapy in patients with stable refractory angina remarkably decreased the inflammatory markers HSP60, MCP-1 and IL-1beta in serum levels also the decreased levels were found in serum levels of oxidative stress marker 8-iso-PGF2beta serum level.	eecp	8-12	interleukin 1 alpha	Homo sapiens	126-134
32333962-7	2020	The SCFA mixture, as well as several individual SCFAs at the highest concentrations used in the mixture (15-236 muM), decreased the secretion of interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-alpha, and cytotoxins by immune-stimulated THP-1 cells.	Fatty Acids, Volatile	4-8	interleukin 1 alpha	Homo sapiens	145-167
32333962-7	2020	The SCFA mixture, as well as several individual SCFAs at the highest concentrations used in the mixture (15-236 muM), decreased the secretion of interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-alpha, and cytotoxins by immune-stimulated THP-1 cells.	Fatty Acids, Volatile	48-53	interleukin 1 alpha	Homo sapiens	145-167
32228128-12	2020	CONCLUSION: The association between IL-1beta rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, alpha-tocopherol and vitamin D.	Ascorbic Acid	110-123	interleukin 1 alpha	Homo sapiens	36-44
32198705-7	2020	Pinitol suppresses the expression and secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6.	pinitol	0-7	interleukin 1 alpha	Homo sapiens	97-105
32228128-12	2020	CONCLUSION: The association between IL-1beta rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, alpha-tocopherol and vitamin D.	alpha-Tocopherol	125-141	interleukin 1 alpha	Homo sapiens	36-44
32228128-12	2020	CONCLUSION: The association between IL-1beta rs16944 genotype and CXCL10 levels was modified by the levels of ascorbic acid, alpha-tocopherol and vitamin D.	Vitamin D	146-155	interleukin 1 alpha	Homo sapiens	36-44
32581510-0	2020	Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-kappaB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1beta-Stimulated SW1353 Cells.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	124-132
32469177-6	2020	RESULTS: U937 cells treated with 100 mM ethanol for 24 h induced NLRP3 and interleukin (IL)-1beta expression.	Ethanol	40-47	interleukin 1 alpha	Homo sapiens	75-97
32469177-9	2020	Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone.	Ethanol	15-22	interleukin 1 alpha	Homo sapiens	43-51
32469177-9	2020	Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone.	Uric Acid	118-121	interleukin 1 alpha	Homo sapiens	43-51
32469177-10	2020	Treatment with 100mM ethanol for 24 h downregulated NLRP3 and IL-1beta expression in MSU crystal-activated U937 cells transfected with TXNIP siRNA, compared to those with scramble siRNA.	Ethanol	21-28	interleukin 1 alpha	Homo sapiens	62-70
32251722-4	2020	In addition to the effect as a carbonic anhydrase inhibitor, methazolamide directly activates the transcription factor anti-oxidative nuclear factor-related factor 2 (Nrf2) and inhibits interleukin-1beta (IL-1beta) release.	Methazolamide	61-74	interleukin 1 alpha	Homo sapiens	205-213
32485858-2	2020	In this study, the potential effects of javamide-II on IL-6, IL-1beta and TNF-alpha productions were determined using their ELISA kits in macrophage-like THP-1 cells.	javamide-ii	40-51	interleukin 1 alpha	Homo sapiens	61-69
32481596-6	2020	Cellular ceramide was elevated 2.67 +- 1.07-fold in RPE cells derived from diabetic donors compared to control donors, and these changes correlated with increased gene expression of IL-1beta, IL-6, and ASM.	Ceramides	9-17	interleukin 1 alpha	Homo sapiens	182-190
32581510-7	2020	Results: IL-1beta treatment increased the expression of TLR4/NF-kappaB and phosphorylation of PI3K/Akt and FoxO1, while additional resveratrol further upregulated the expression of PI3K/Akt and FoxO1 phosphorylation but downregulated TLR4 signals in SW1353 cells.	Resveratrol	131-142	interleukin 1 alpha	Homo sapiens	9-17
32449901-11	2020	The production of TNF-alpha, IL-6, and IL-1ss was significantly suppressed by roflumilast.	Roflumilast	78-89	interleukin 1 alpha	Homo sapiens	39-43
32457454-6	2020	IL-1alpha/beta induced fibroblast pro-inflammatory responses (CXCL8/IL-8, IL-6, TSLP, GM-CSF) and suppressed ECM-production (collagen, fibronectin, periostin) and the cell"s ability to repair and remodel fibrillar collagen I via LOX, LOXL1 and LOXL2 activity, as confirmed by inhibition with beta-aminopropionitrile.	Aminopropionitrile	292-315	interleukin 1 alpha	Homo sapiens	0-14
32523550-7	2020	In line with the supposed switch to a pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP), we found that both RS and DS upregulated IL-1beta and released HMGB-1 from the nucleus, while RS also showed IL-6 upregulation.	ds	154-156	interleukin 1 alpha	Homo sapiens	169-177
32466274-5	2020	Moreover, multilayers containing either HA or Hep dampened the inflammatory response visible by reduced adhesion, formation of multinucleated giant cells (MNGCs) and IL-1beta release, which was studied using THP-1 derived macrophages.	Heparin	46-49	interleukin 1 alpha	Homo sapiens	166-174
32456215-4	2020	Here, we report a novel finding that PRMT5 is phosphorylated on serine 15 (S15) in response to interleukin-1beta (IL-1beta) stimulation.	Serine	64-70	interleukin 1 alpha	Homo sapiens	114-122
32565872-6	2020	On average, 1, 2.5, and 5 mug/mL doses of LI13019F1 protected 34.62, 47.66, and 62.29% SW1353 human chondrosarcoma cells from IL-1beta induced SOX-9 depletion, respectively.	li13019f1	42-51	interleukin 1 alpha	Homo sapiens	126-134
32439949-5	2020	An in vitro study indicated that high glucose increased IL-1beta and IL-18 expression and activated the NLRP3 inflammasome via upregulation of MARK4 in human umbilical vein endothelial cells (HUVECs).	Glucose	38-45	interleukin 1 alpha	Homo sapiens	56-64
32018221-3	2020	Notably, we found that high-glucose (50 mM) increased the expression levels of Caspase-1, Gasdermin D, NLRP3, IL-1beta and IL-18 in ARPE-19 cells, which indicated that high-glucose triggered pyroptotic cell death.	Glucose	173-180	interleukin 1 alpha	Homo sapiens	110-118
32429415-0	2020	Modulatory Effect of Nicotinic Acid on the Metabolism of Caco-2 Cells Exposed to IL-1beta and LPS.	Niacin	21-35	interleukin 1 alpha	Homo sapiens	81-89
32477361-6	2020	Since IL-1 may contribute to LZD toxicity and does influence TB pathology, we targeted this pathway with a potential host-directed therapy (HDT).	Terbium	61-63	interleukin 1 alpha	Homo sapiens	6-10
32477361-7	2020	We hypothesized LZD efficacy could be enhanced by modulation of IL-1 pathway to reduce bone marrow toxicity and TB associated-inflammation.	Linezolid	16-19	interleukin 1 alpha	Homo sapiens	64-68
32477361-7	2020	We hypothesized LZD efficacy could be enhanced by modulation of IL-1 pathway to reduce bone marrow toxicity and TB associated-inflammation.	Terbium	112-114	interleukin 1 alpha	Homo sapiens	64-68
32477361-14	2020	Together, our data support that inhibition of IL-1 in combination with LZD has potential to be an effective HDT for TB and the need for further research in this area.	Terbium	116-118	interleukin 1 alpha	Homo sapiens	46-50
32017949-11	2020	RESULTS: MHF treatment reduced lung index, W/D ratios, and serum levels of inflammatory factors (IL-6, TNF-alpha, IL-1beta, PLA2, LBT4 and ICAM-1) in IAV-infected mice.	monomethyl fumarate	9-12	interleukin 1 alpha	Homo sapiens	114-122
32476816-9	2020	IL-1 beta, IL-2, IL-6, and TNF-alpha in tears and conjunctiva increased in the DESOS groups compared to the CMDE and control groups, indicating a high correlation with hypersensitivity status in the DESOS groups.	desos	79-84	interleukin 1 alpha	Homo sapiens	0-9
32032599-10	2020	Furthermore, both our in vivo and in vitro results reveal that WFA treatment could significantly reduce levels of several neuroinflammation cytokines (IL-1beta, IL-6, and TNF-alpha), which correlate with an overall reduction in microglial activation.	withaferin A	63-66	interleukin 1 alpha	Homo sapiens	151-159
32200535-4	2020	By inhibition of NF-kappaB, 1,8-cineole, at relevant plasma concentrations (1.5 microg/ml), strongly and significantly inhibited in normal human monocyte lipopolysaccharide (LPS)-stimulated cytokines relevant for exacerbation (tumour necrosis factor alpha (TNFalpha), interleukin (IL)-1beta and systemic inflammation (IL-6, IL-8).	Eucalyptol	28-39	interleukin 1 alpha	Homo sapiens	268-290
32200535-6	2020	In lymphocytes from healthy human donors 1,8-cineole inhibited TNFalpha, IL-1beta, IL-4 and IL-5 and demonstrated for the first time control of Th1/2-type inflammation.	Eucalyptol	41-52	interleukin 1 alpha	Homo sapiens	73-81
32008371-7	2020	Such metabolic products involve succinate, which stimulates inflammation through ROS-dependent stabilisation of HIF-1alpha, promoting IL-1beta production by the inflammasome.	Succinates	32-41	interleukin 1 alpha	Homo sapiens	134-142
32088265-3	2020	Here, we report that lysosomotropic drugs potentiate pro-inflammatory effects in response to IL-1beta via a mechanism involving reactive oxygen species, p38 mitogen-activated protein kinase and reduced IL-1 receptor internalization.	Oxygen	137-143	interleukin 1 alpha	Homo sapiens	93-101
32088265-4	2020	Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome.	Chloroquine	0-11	interleukin 1 alpha	Homo sapiens	45-53
32088265-4	2020	Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome.	Hydroxychloroquine	16-34	interleukin 1 alpha	Homo sapiens	45-53
32014690-6	2020	Here we found that TDI induced pyroptosis in 16HBE cells, as evidenced by enhanced expressions of caspase-1 and elevated levels of LDH, IL-1beta and HMGB1.	Toluene 2,4-Diisocyanate	19-22	interleukin 1 alpha	Homo sapiens	136-144
32058211-4	2020	in vitro study, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by Ellagic acid (EA).	Nitric Oxide	113-125	interleukin 1 alpha	Homo sapiens	16-24
32101839-13	2020	However, the effects of IL-1beta could be ameliorated by the addition of miR-140-3p mimics.	mir-140-3p	73-83	interleukin 1 alpha	Homo sapiens	24-32
32101839-15	2020	IL-1beta-induced upregulation of CXCR4 could be blocked by miR-140-3p mimics.	mir-140-3p	59-69	interleukin 1 alpha	Homo sapiens	0-8
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	276-284
32124251-5	2020	Curcumin treatment also decreased oxidative stress injury following IL-1beta stimulation.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	68-76
32205228-10	2020	Cadmium exposures were associated with increased IL-1beta (beta = 77.8 +- 26.3, p = 0.003) and IL-8 (beta = 419.5 +- 201.2, p = 0.04).	Cadmium	0-7	interleukin 1 alpha	Homo sapiens	49-57
32205228-12	2020	Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8.	Benzene	36-43	interleukin 1 alpha	Homo sapiens	110-118
32205228-12	2020	Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8.	Cadmium	55-62	interleukin 1 alpha	Homo sapiens	110-118
32205228-13	2020	In obese subjects, lead was also inversely associated with leptin, and toluene was positively associated with IL-1beta.	Toluene	71-78	interleukin 1 alpha	Homo sapiens	110-118
32525823-9	2020	The increased activities of TNFalpha, IL-1beta and IL-6 induced by CSE were partially attenuated by Dex.	Dexmedetomidine	100-103	interleukin 1 alpha	Homo sapiens	38-46
32156572-8	2020	Recent studies have reported that viroporin activity is capable of inducing inflammasome activity and production of IL-1beta, where NLRP3 is shown to be regulated by fluxes of K+, H+ and Ca2+ in addition to reactive oxygen species, autophagy and endoplasmic reticulum stress.	Reactive Oxygen Species	207-230	interleukin 1 alpha	Homo sapiens	116-124
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	81-95	interleukin 1 alpha	Homo sapiens	131-139
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	97-100	interleukin 1 alpha	Homo sapiens	131-139
32028542-7	2020	RESULTS: Treatment with OLA counteracted IL-1beta-evoked chondrocyte growth inhibition, apoptosis, caspase3 production, MDA and 8-OHdG release.	Oleanolic Acid	24-27	interleukin 1 alpha	Homo sapiens	41-49
32028542-8	2020	Additionally, FGF2 protein expression levels elevated by IL-1beta were down-regulated by OLA and miR-148-3p mimics transfection.	Oleanolic Acid	89-92	interleukin 1 alpha	Homo sapiens	57-65
32028542-9	2020	IL-1beta-induced down-regulation of miR-148-3p in chondrocytes was evaluated by OLA administration.	Oleanolic Acid	80-83	interleukin 1 alpha	Homo sapiens	0-8
32028542-12	2020	CONCLUSIONS: Our present findings expounded a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade the miR-148-3p/FGF2 signaling pathway might be a potential therapeutic target of OLA to prevent the progression of osteoarthritis (OA).	Oleanolic Acid	67-70	interleukin 1 alpha	Homo sapiens	74-82
32028542-12	2020	CONCLUSIONS: Our present findings expounded a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade the miR-148-3p/FGF2 signaling pathway might be a potential therapeutic target of OLA to prevent the progression of osteoarthritis (OA).	Oleanolic Acid	224-227	interleukin 1 alpha	Homo sapiens	74-82
32461350-0	2020	Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes.	Saponins	49-56	interleukin 1 alpha	Homo sapiens	75-79
32461350-5	2020	METHODS AND RESULTS: Here, we show that simultaneous administration of cytidyl guanosyl (CpG) with saponin-based adjuvants following cryoablation affects multifunctional T-cell numbers and interleukin (IL)-1 induced polymorphonuclear neutrophil recruitment in the tumor draining lymph nodes, relative to either adjuvant alone.	cytidyl guanosyl	71-87	interleukin 1 alpha	Homo sapiens	189-207
32461350-5	2020	METHODS AND RESULTS: Here, we show that simultaneous administration of cytidyl guanosyl (CpG) with saponin-based adjuvants following cryoablation affects multifunctional T-cell numbers and interleukin (IL)-1 induced polymorphonuclear neutrophil recruitment in the tumor draining lymph nodes, relative to either adjuvant alone.	saponin-based adjuvants	99-122	interleukin 1 alpha	Homo sapiens	189-207
32461350-6	2020	The combination of CpG and saponin-based adjuvants induces potent DC maturation (mainly CpG-mediated), antigen cross-presentation (mainly saponin-based adjuvant mediated), while excretion of IL-1beta by DCs in vitro depends on the presence of both adjuvants.	Saponins	27-34	interleukin 1 alpha	Homo sapiens	191-199
32461350-6	2020	The combination of CpG and saponin-based adjuvants induces potent DC maturation (mainly CpG-mediated), antigen cross-presentation (mainly saponin-based adjuvant mediated), while excretion of IL-1beta by DCs in vitro depends on the presence of both adjuvants.	saponin-based adjuvant	27-49	interleukin 1 alpha	Homo sapiens	191-199
33005902-2	2020	Dapansutrile inhibits the NLRP3 inflammasome and subsequent activation of IL-1beta.	dapansutrile	0-12	interleukin 1 alpha	Homo sapiens	74-82
32186758-7	2020	The M1-related phenotypic indicators, iNOS, TNF-alpha, IL-1beta, IL-6 and CD86, were inhibited by the NF-kappaB (p65) signalling pathway inhibitor BAY117082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	147-156	interleukin 1 alpha	Homo sapiens	55-63
31999881-5	2020	mRNA expression of the pro-inflammatory cytokine TNF-alpha, IL-1beta and IL-6 was decreased significantly in ECG- and EGCG-treated HDPCs.	epigallocatechin gallate	118-122	interleukin 1 alpha	Homo sapiens	60-68
32454938-12	2020	Tanshinone IIA downregulated the mRNA expression levels of various factors induced by TBI, including CD11, IL-1beta, and TNF-alpha.	1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE	11-14	interleukin 1 alpha	Homo sapiens	107-115
32350292-6	2020	The most potent compound, (S)-(+)-carvone, significantly decreased the expression of NOS2 and IL-1beta in macrophages and in a cell model of osteoarthritis using primary human chondrocytes.	carvone	26-41	interleukin 1 alpha	Homo sapiens	94-102
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Carotenoids	28-39	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Beta-Cryptoxanthin	47-65	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Fructose	104-112	interleukin 1 alpha	Homo sapiens	213-221
32332775-4	2020	This interaction was enhanced by treatment with the antineoplastic drug etoposide, which suggests a role for the IL-1alpha p53 interaction in genotoxic stress.	Etoposide	72-81	interleukin 1 alpha	Homo sapiens	113-122
32420343-6	2020	Our data showed that high glucose induced NLRP3-caspase-1-GSDMD activation and pore formation in a dose- and time-dependent manner (p < 0.05) and resulted in the inflammatory cytokines IL-1beta and IL-18 and lactate dehydrogenase (LDH) release from HRPs (p < 0.05), which are all signs of HRP pyroptosis.	Glucose	26-33	interleukin 1 alpha	Homo sapiens	185-193
32431696-7	2020	However, reduction in IL-1beta cytokine expression levels strongly correlated with reduced lung damage and improved influenza disease outcome in female mice upon testosterone treatment.	Testosterone	162-174	interleukin 1 alpha	Homo sapiens	22-30
32316988-5	2020	RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner.	si10	26-30	interleukin 1 alpha	Homo sapiens	154-172
32316988-5	2020	RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner.	si10	26-30	interleukin 1 alpha	Homo sapiens	174-183
32316988-5	2020	RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner.	si10	26-30	interleukin 1 alpha	Homo sapiens	208-216
32059850-3	2020	Both the in vitro and in vivo results clearly showed that YDWPGGRN significantly inhibited the LPS-stimulated NO, IL-1beta, IL-6 and TNF-alpha production but promoted the release of an anti-inflammatory cytokine, IL-10.	ydwpggrn	58-66	interleukin 1 alpha	Homo sapiens	114-122
32022261-7	2020	RESULTS: Treatment with APG-157 resulted in circulating concentrations of curcumin and analogs peaking at 3 hours with reduced IL-1beta, IL-6, and IL-8 concentrations in the salivary supernatant fluid of patients with cancer.	apg	24-27	interleukin 1 alpha	Homo sapiens	127-135
32296107-7	2020	RSV treatment improved intracellular Ca2+ responses, mitochondrial function, suppressed the generation of cytokine (IL-1beta and TNF-alpha), cytosolic and mitochondrial ROS in the SH-SY5Y cells.	Resveratrol	0-3	interleukin 1 alpha	Homo sapiens	116-124
32341639-9	2020	The expressions of IL-1beta, IL-6, TNF-alpha, iNOS, p-Syk, p-NF-kappa B, alpha-SMA and FN in BMDM inflammatory model were significantly upregulated with TDB treatment.	TDB	153-156	interleukin 1 alpha	Homo sapiens	19-27
32322257-4	2020	These cells displayed the typical morphology and markers of astroglia, and were susceptible to the action of inflammatory mediators and BAF312, because expressing receptors for IL1, IL17, and S1P (namely S1P1 and S1P3).	siponimod	136-142	interleukin 1 alpha	Homo sapiens	177-180
32197070-0	2020	Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1beta.	Glucose	82-89	interleukin 1 alpha	Homo sapiens	98-106
32197070-3	2020	Here, we hypothesized that glucose-induced IL-1beta leads to an exaggerated insulin response in this condition.	Glucose	27-34	interleukin 1 alpha	Homo sapiens	43-51
32264868-8	2020	EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC.	empagliflozin	0-4	interleukin 1 alpha	Homo sapiens	71-78
32264868-8	2020	EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC.	dapagliflozin	9-13	interleukin 1 alpha	Homo sapiens	71-78
32264868-8	2020	EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC.	stearic acid	46-48	interleukin 1 alpha	Homo sapiens	71-78
32252692-11	2020	The levels of inflammation related proteins NLRP3, ASC, caspase1, IL-1beta and IL-18 was also inhibited after the treatment of ripasudil.	K-115	127-136	interleukin 1 alpha	Homo sapiens	66-74
32252692-13	2020	CONCLUSION: Ripasudil relieved the inflammatory injury of RPE cells by upregulating miR-136-5p, therefore inhibiting the expression of ROCK1, ROCK2, NLRP3, ASC, caspase1, IL-1beta and IL-18.	K-115	12-21	interleukin 1 alpha	Homo sapiens	171-179
32001222-6	2020	EGCG priming alleviated the detrimental effects of thermal stress in hWJMSCs as observed by significant down-regulation in expression of BCL2 associated X (BAX), interleukin 6 (IL6), and interleukin 1 beta (IL1beta) genes, while proliferating cell nuclear antigen (PCNA), BCL2 like 1 (BCL2L1), vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGFbeta1), hepatocyte growth factor (HGF) and interleukin 4 (IL4) genes were up-regulated.	epigallocatechin gallate	0-4	interleukin 1 alpha	Homo sapiens	207-214
32000013-7	2020	At the same time, the induction of TNFalpha and IL-1beta was diminished by the Ca2+/calmodulin-dependent protein kinase inhibitor, whereas the induction of IL-6 and CCL-2 was reduced by the inhibitor of phosphoinositide 3-kinase.	Calcium	79-83	interleukin 1 alpha	Homo sapiens	48-56
32061902-8	2020	Anthocyanin supplementation also down-regulated the expression of NF-kappaB dependent genes including TNF-alpha (-28% and -15%), IL-6 (-16.1% and-13.6%), IL-1A (-21.5% and-12.9%), PCAM-1 (-15% and-17.5%), and COX-2(-26% and-27%) in both MetS and Control group respectively (P-value &lt; 0.05).	Anthocyanins	0-11	interleukin 1 alpha	Homo sapiens	154-159
31773440-6	2020	Results disclosed that ar-turmerone dose-dependently suppressed proliferation, facilitated apoptosis, and reduced TNF-alpha-mediated production of interleukin (IL)-1beta, IL-6, and IL-8 in HaCaT cells.	ar-turmerone	23-35	interleukin 1 alpha	Homo sapiens	147-169
32452426-4	2020	We hypothesize that glibenclamide may also interfere with monocyte mediated immune responses against Mtb and alter the balance between IL-1beta and IFNalpha-mediated immunity.	Glyburide	20-33	interleukin 1 alpha	Homo sapiens	135-143
32452426-6	2020	We demonstrate that monocytes from diabetes patients who were being treated with glibenclamide showed reduced IL-1beta and IL-8 secretion when exposed to Mtb.	Glyburide	81-94	interleukin 1 alpha	Homo sapiens	110-118
32452426-9	2020	Taken together, our data show that glibenclamide might exacerbate susceptibility of diabetes patients to Mtb infection by reducing IL-1beta and IL-8 production by monocytes.	Glyburide	35-48	interleukin 1 alpha	Homo sapiens	131-139
32724621-8	2020	The mRNA and protein expression levels of inflammatory cytokines (IL-1beta and TNF-alpha) were significantly elevated by LCFA.	lcfa	121-125	interleukin 1 alpha	Homo sapiens	66-74
32223187-6	2020	In addition, silica increased the expression of interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), and T3 treatment reduced those pro-inflammatory cytokines secretion.	Silicon Dioxide	13-19	interleukin 1 alpha	Homo sapiens	68-76
32467560-11	2020	RESULTS The miR-423-5p overexpression markedly, and negatively regulated the protective effects of NLRX1 on IL-1beta induced NP cells.	mir-423-5p	12-22	interleukin 1 alpha	Homo sapiens	108-116
32429534-9	2020	Finally, NTS and MSM inhibited the high glucose-induced expression of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha and binding of NF-kappaB protein to the DNA of proinflammatory cytokines.	Glucose	40-47	interleukin 1 alpha	Homo sapiens	70-92
32443416-3	2020	In vitro, increased TNF-alpha and IL-1ss cytokine mRNA expression was observed in Nano-11-KAg-poly(I:C)-treated porcine monocyte-derived dendritic cells.	nano-11-kag-poly(i	82-100	interleukin 1 alpha	Homo sapiens	34-38
32443416-3	2020	In vitro, increased TNF-alpha and IL-1ss cytokine mRNA expression was observed in Nano-11-KAg-poly(I:C)-treated porcine monocyte-derived dendritic cells.	Carbon	101-103	interleukin 1 alpha	Homo sapiens	34-38
32172867-4	2020	SPS-SeNPs was confirmed to inhibit the production of nitric oxide (NO) in RAW 264.7 inflammatory macrophages induced by lipopolysaccharide (LPS), and downregulated the mRNA expression of TNF-alpha, IL-1beta and iNOS.	Sodium phenolsulfonate	0-3	interleukin 1 alpha	Homo sapiens	198-206
32423023-1	2020	The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense.	Leucine	38-45	interleukin 1 alpha	Homo sapiens	325-333
32477344-10	2020	DFX also supports innate immune function by inducing IL1beta production in human macrophages during early infection with Mtb and upon stimulation with LPS.	Deferoxamine	0-3	interleukin 1 alpha	Homo sapiens	53-60
32477344-11	2020	Moreover, using hypoxia, Western blot and ChIP-qPCR analyses, we show that DFX modulates IL1beta levels in these cells in a HIF1alpha-mediated manner.	Deferoxamine	75-78	interleukin 1 alpha	Homo sapiens	89-96
32477360-13	2020	In conclusion, we suggest that in the presence of intolerance or resistance to colchicine, interleukin (IL)-1 inhibition could suppress peritoneal inflammation and prevent MSTs.	Colchicine	79-89	interleukin 1 alpha	Homo sapiens	91-109
32518807-9	2020	After metformin treatment, expression of interleukin 6 (IL-6), TNF-alpha, and IL-1beta were significantly downregulated in RA-FLSs; however, increased expression of p-AMPK-alpha1, protein kinase A (PKA)-alpha1, and HAPLN1 (hyaluronan and proteoglycan link protein 1) was observed.	Metformin	6-15	interleukin 1 alpha	Homo sapiens	78-86
32397371-6	2020	In response to lenvatinib, four and 16 genes were upregulated in Huh7 and HepG2 cells, respectively, and two genes (interleukin 1 alpha and TLR4) were upregulated in both cells.	lenvatinib	15-25	interleukin 1 alpha	Homo sapiens	116-135
32397236-7	2020	In addition, P2Y2R activation by ATP induced the secretion of IL-1beta and VEGF-A, as well as invasion, in MDA-MB-231 and RT-R-MDA-MB-231 cells, which was inhibited by NLRC4, ASC, and caspase-1 small interfering RNA (siRNA).	Adenosine Triphosphate	33-36	interleukin 1 alpha	Homo sapiens	62-70
32374672-0	2020	IL-1beta dysregulates cGMP signaling in the newborn lung.	Cyclic GMP	22-26	interleukin 1 alpha	Homo sapiens	0-8
32374672-3	2020	We determined how IL-1beta regulates the expression of the alpha1-subunit of soluble guanylate cyclase (sGCalpha1), a prime effector of pulmonary cGMP signaling.	Cyclic GMP	146-150	interleukin 1 alpha	Homo sapiens	18-26
32371889-0	2020	N-GSDMD trafficking to neutrophil organelles facilitates IL-1beta release independently of plasma membrane pores and pyroptosis.	n-gsdmd	0-7	interleukin 1 alpha	Homo sapiens	57-65
32194260-9	2020	Statement of Significance This study was conducted to elucidate the molecular mechanisms of metal particle-induced IL-1beta secretion in human primary macrophages.	Metals	92-97	interleukin 1 alpha	Homo sapiens	115-123
32323422-4	2020	Of these senescence-inducing cytokines, the activity of five (namely IL-1beta, IL-13, MCP-2, MIP-3alpha, and SDF-1alpha) was significantly inhibited by treatment with cetuximab (an antibody targeting epidermal growth factor receptor [EGFR]), gefitinib (a small molecule inhibitor of EGFR), and EGFR knockdown.	Gefitinib	242-251	interleukin 1 alpha	Homo sapiens	69-77
32018221-3	2020	Notably, we found that high-glucose (50 mM) increased the expression levels of Caspase-1, Gasdermin D, NLRP3, IL-1beta and IL-18 in ARPE-19 cells, which indicated that high-glucose triggered pyroptotic cell death.	Glucose	28-35	interleukin 1 alpha	Homo sapiens	110-118
32058211-4	2020	in vitro study, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by Ellagic acid (EA).	Dinoprostone	173-189	interleukin 1 alpha	Homo sapiens	16-24
32058211-4	2020	in vitro study, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by Ellagic acid (EA).	Dinoprostone	191-195	interleukin 1 alpha	Homo sapiens	16-24
32058211-4	2020	in vitro study, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by Ellagic acid (EA).	Ellagic Acid	241-253	interleukin 1 alpha	Homo sapiens	16-24
32058211-4	2020	in vitro study, IL-1beta-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by Ellagic acid (EA).	Ellagic Acid	255-257	interleukin 1 alpha	Homo sapiens	16-24
32058211-5	2020	Moreover, Ellagic acid (EA) down-regulated the IL-1beta-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) while up-regulated the collagen of type II and aggrecan.	Ellagic Acid	10-22	interleukin 1 alpha	Homo sapiens	47-55
32058211-5	2020	Moreover, Ellagic acid (EA) down-regulated the IL-1beta-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) while up-regulated the collagen of type II and aggrecan.	Ellagic Acid	24-26	interleukin 1 alpha	Homo sapiens	47-55
32058211-6	2020	Mechanistically, we revealed that Ellagic acid (EA) suppressed nuclear factor kappa B (NF-kappaB) signaling in IL-1beta -induced chondrocytes.	Ellagic Acid	34-46	interleukin 1 alpha	Homo sapiens	111-119
32058211-6	2020	Mechanistically, we revealed that Ellagic acid (EA) suppressed nuclear factor kappa B (NF-kappaB) signaling in IL-1beta -induced chondrocytes.	Ellagic Acid	48-50	interleukin 1 alpha	Homo sapiens	111-119
32179281-0	2020	Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1beta inhibitors.	Chalcone	50-58	interleukin 1 alpha	Homo sapiens	103-111
32179281-0	2020	Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1beta inhibitors.	bispiperazine	79-92	interleukin 1 alpha	Homo sapiens	103-111
32179281-2	2020	The results indicated that most bispiperazinochalcone derivatives displayed good inhibition of NO (IC50 < 20 muM) and low cytotoxicity (CC50 > 40 muM), and selectively inhibited the production of IL-1beta via inhibiting NLRP3 inflammasome activation, as promising candidate compounds for the treatment of NLRP3 inflammasome-driven diseases.	bispiperazinochalcone	32-53	interleukin 1 alpha	Homo sapiens	196-204
32317086-9	2020	Also, mRNA levels of tamoxifen-induced pyroptosis-related genes, IL-1beta, NLRP3, and procaspase-1, also decreased in the presence of sulfasalazine in RPE cells.	Tamoxifen	21-30	interleukin 1 alpha	Homo sapiens	65-73
32317086-9	2020	Also, mRNA levels of tamoxifen-induced pyroptosis-related genes, IL-1beta, NLRP3, and procaspase-1, also decreased in the presence of sulfasalazine in RPE cells.	Sulfasalazine	134-147	interleukin 1 alpha	Homo sapiens	65-73
33073254-7	2020	As expected, DEX treatment suppressed multiple LPS-induced pro-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-1beta, .TNF-alpha) by >85% and increased the anti-inflammatory cytokine IL-10 by 80%.	Dexamethasone	13-16	interleukin 1 alpha	Homo sapiens	110-118
32049375-7	2020	The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry.	mci	4-7	interleukin 1 alpha	Homo sapiens	40-48
32049375-7	2020	The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry.	Inositol	8-10	interleukin 1 alpha	Homo sapiens	40-48
32049375-7	2020	The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry.	Inositol	15-17	interleukin 1 alpha	Homo sapiens	40-48
32319486-5	2020	Furthermore, Cr(vi) could induce the activation of the nuclear factor kappa B (NF-kappaB) signaling pathway, the accumulation of p65 in the nucleus, and the increase in the phosphorylation of IkappaB and the expression of cleaved caspase-1 and IL-1beta in THP-1 cells.	chromium hexavalent ion	13-19	interleukin 1 alpha	Homo sapiens	244-252
32323738-8	2020	Furthermore, geniposide mitigated the ox-LDL-induced inflammatory response, demonstrated by a downregulation of pro-inflammatory cytokine (IL-1beta, IL-6, and TNF-alpha) levels and an upregulation of anti-inflammatory cytokine (IL-10) level.	geniposide	13-23	interleukin 1 alpha	Homo sapiens	139-147
32482058-9	2020	Combination therapy with PDRN and pirfenidone and PDRN monotherapy suppressed expression of TNF-alpha and IL-1beta.	pirfenidone	34-45	interleukin 1 alpha	Homo sapiens	106-114
32020710-5	2020	Our results indicated that paroxetine attenuates proinflammatory cytokine production (interleukin-1beta [IL-1beta], IL-17, and tumor necrosis factor-alpha) and increases expression of IL-10 and JAK2/STAT3 evidence for macrophages polarization to M2 subset and functional dendritic cells depletion.	Paroxetine	27-37	interleukin 1 alpha	Homo sapiens	105-113
32723437-7	2020	Rofecoxib reversed the IL-1beta-induced upregulation of collagen X, COX-2, PGE-2, Runx-2, and MMP-13 expression, and promoted the viability of collagen II, SOX-9 expression of CHs.	rofecoxib	0-9	interleukin 1 alpha	Homo sapiens	23-31
32723437-8	2020	Furthermore, Rofecoxib suppressed Axin2, beta-catenin, and GSK3beta expression of the Wnt pathway, which was activated by IL-1beta or human recombinant Wnt-1 protein treatment.	rofecoxib	13-22	interleukin 1 alpha	Homo sapiens	122-130
32040591-9	2020	PMB suppressed IL-1beta (P = 0.035) and IL-6 (P = 0.0487) production in the 3 h PPB of the PS after 24 h incubation at 37 C compared to the vehicle control, suggesting the presence of LPS.	Polymyxin B	0-3	interleukin 1 alpha	Homo sapiens	15-23
32204034-5	2020	It is found that macrophages grown on MAO-modified Ti surface were switched to M1-like phenotype, evidenced by the promoted expressions of inflammatory genes (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta) and production of pro-inflammatory cytokine TNF-alpha.	5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE	38-41	interleukin 1 alpha	Homo sapiens	225-233
31896762-3	2020	Higher DMPA levels were associated with reduced CVL concentrations of GCSF, MCSF, IL-16, CTACK, LIF, IL-1alpha, and SCGF-beta in adjusted linear mixed models.	N,N-dimethyl-4-anisidine	7-11	interleukin 1 alpha	Homo sapiens	101-110
32028022-7	2020	Low dose Nx reduced the percentage of IL-1beta producing primary monocytes and macrophages.	Naproxen	9-11	interleukin 1 alpha	Homo sapiens	38-46
32028022-9	2020	Low dose Nx both prevented and reduced inflammatory responses of a human monocytic cell line and reduced IL-1beta production by primary human SF monocytes and macrophages.	Naproxen	9-11	interleukin 1 alpha	Homo sapiens	105-113
32375462-1	2020	OBJECTIVE: The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1beta (IL-1beta) level since increasing level of IL-1beta is linked with PTB.	Hydrocortisone	122-130	interleukin 1 alpha	Homo sapiens	273-281
32375462-1	2020	OBJECTIVE: The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1beta (IL-1beta) level since increasing level of IL-1beta is linked with PTB.	Hydrocortisone	122-130	interleukin 1 alpha	Homo sapiens	315-323
32410835-4	2020	Confocal laser scanning microscopy and flow cytometry revealed that IL-1beta promoted uptake of fluorescent Dil-labelled Ox-LDL(Dil-Ox-LDL) by HMCs and the enhanced uptake of Dil-Ox-LDL was partially inhibited by an anti-LOX-1 antibody evaluated by flow cytometry.	3,3'-dioctadecylindocarbocyanine	108-111	interleukin 1 alpha	Homo sapiens	68-76
32349389-4	2020	In the present study, we evaluated the protective anti-inflammatory and anti-apoptotic effects, as well as the underlying mechanisms, of LI73014F2 in interleukin (IL)-1beta-induced inflammation in human primary chondrocytes.	li73014f2	137-146	interleukin 1 alpha	Homo sapiens	150-172
32349389-5	2020	Human chondrocytes were treated with LI73014F2 (0, 12.5, 25 and 50 mug/mL) in IL-1beta (10 ng/mL)-containing chondrocyte growth medium for 24 h. Cell viability was assessed using an MTT assay.	li73014f2	37-46	interleukin 1 alpha	Homo sapiens	78-86
32349389-8	2020	Moreover, the data suggested that LI73014F2 reduced IL-1beta-induced inflammation and apoptosis, at least partially via the inhibition of the NF-kappaB/MAPK signaling pathway.	li73014f2	34-43	interleukin 1 alpha	Homo sapiens	52-60
32550560-2	2020	In this study, we investigated whether high glucose and/or tumor necrosis factor (TNF) would enhance pro-inflammatory cytokine expression of tumor necrosis factor (TNF) and interleukin (IL)-1beta (IL1B) by altering histone modifications in U937, a juvenile macrophage cell line.	Glucose	44-51	interleukin 1 alpha	Homo sapiens	173-195
32203978-1	2020	Background: Inflammatory cytokines, such as interleukin (IL)-1beta, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1beta can reverse these effects is unclear.	Iron	74-78	interleukin 1 alpha	Homo sapiens	44-66
32326355-7	2020	Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta.	Trichothecenes	5-19	interleukin 1 alpha	Homo sapiens	138-146
32191437-0	2020	Laquinimod Mitigated IL-1beta-Induced Impairment of the Cartilage Extracellular Matrix in Human ATDC5 Chondrocytes.	laquinimod	0-10	interleukin 1 alpha	Homo sapiens	21-29
32191437-5	2020	In our research, we found that laquinimod could ameliorate IL-1beta-induced generation of ROS and improve mitochondrial function by increasing mitochondrial membrane potential (DeltaPsim).	laquinimod	31-41	interleukin 1 alpha	Homo sapiens	59-67
32191437-5	2020	In our research, we found that laquinimod could ameliorate IL-1beta-induced generation of ROS and improve mitochondrial function by increasing mitochondrial membrane potential (DeltaPsim).	ros	90-93	interleukin 1 alpha	Homo sapiens	59-67
32191437-6	2020	Furthermore, treatment with laquinimod suppressed IL-1beta-induced production of TNF-alpha and IL-6.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	50-58
32191437-9	2020	Mechanistically, laquinimod ameliorated IL-1beta-induced inflammation and degeneration of ECM by suppressing the activation of NF-kappaB.	laquinimod	17-27	interleukin 1 alpha	Homo sapiens	40-48
32191437-10	2020	Taken together, our findings reveal that laquinimod possesses a beneficial effect against IL-1beta insults in human chondrocytes, implying an important role of laquinimod in OA.	laquinimod	41-51	interleukin 1 alpha	Homo sapiens	90-98
32035144-4	2020	Our results showed that hesperetin significantly relieved the symptoms of DSS -induced colitis and increased the expressions of zonula occludens-1 (ZO-1), occludin and mucin2 (MUC-2) as well as the decrease of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-18, HMGB1 and IL-6.	hesperetin	24-34	interleukin 1 alpha	Homo sapiens	251-273
31902378-4	2020	Omega-3 fatty acids intake upregulated peroxisome proliferator-activated receptor gamma (P&lt;0.001) and low-density lipoprotein receptor (P=0.004), and downregulated gene expression of interleukin-1 (P=0.002) and tumor necrosis factor alpha (P=0.001) in peripheral blood mononuclear cells of subjects with GDM.	Fatty Acids, Omega-3	0-19	interleukin 1 alpha	Homo sapiens	186-199
32290603-4	2020	The results demonstrated that KC dose-dependently suppressed the production of inflammatory mediators, including NO, PGE2, IL-6, IL1beta, MCP-1, and IFN-beta in LPS-stimulated RAW264.7 macrophages.	lysylcysteine	30-32	interleukin 1 alpha	Homo sapiens	129-136
32290188-7	2020	In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes.	Lactic Acid	65-72	interleukin 1 alpha	Homo sapiens	159-167
32290188-7	2020	In vitro validation experiments revealed that co-incubation with lactate and pyruvate enhances IL-10 production and attenuates the release of pro-inflammatory IL-1beta and IL-6 by LPS-stimulated leukocytes.	Pyruvic Acid	77-85	interleukin 1 alpha	Homo sapiens	159-167
32271889-11	2020	Both caspase-1 activity and release of IL-1beta were reduced by cis-UCA.	cis-Urocanic acid	64-71	interleukin 1 alpha	Homo sapiens	39-47
32271889-15	2020	Cis-UCA can prevent the secretion of IL-1beta and IL-18 and therapeutically reduces the levels of IL-6, IL-8, and LDH in UV-B-stressed HCE cells.	cis-Urocanic acid	0-7	interleukin 1 alpha	Homo sapiens	37-45
32197070-7	2020	Our study proposes a role for glucose-induced IL-1beta in postprandial hypoglycemia after gastric bypass surgery and suggests that SGLT2-inhibitors and IL-1 antagonism may improve this condition.	Glucose	30-37	interleukin 1 alpha	Homo sapiens	46-54
32114511-1	2020	OBJECTIVE: Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals.	Uric Acid	101-117	interleukin 1 alpha	Homo sapiens	43-61
32411755-9	2020	Results: In this study, we found that pre-treatment with wogonoside dramatically suppressed lipopolysaccharide (LPS)-induced increase in the protein and mRNA levels of inflammatory factors in macrophages, such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6.	wogonoside	57-67	interleukin 1 alpha	Homo sapiens	279-301
32411755-13	2020	Additionally, ChIP analysis demonstrated wogonoside to remarkably reduce c-Jun enrichment in COX-2, iNOS, IL-1beta, TNF-alpha, and IL-6 promoters.	wogonoside	41-51	interleukin 1 alpha	Homo sapiens	106-114
31809639-5	2020	A series of function assays, including CCK-8 assay, flow cytometry, and ELISA assay showed that miR-455-3p contributed to IL-1beta-induced apoptosis and inflammation.	mir-455-3p	96-106	interleukin 1 alpha	Homo sapiens	122-130
32079428-8	2020	Significantly lower ISI, HADS, HADS-A, and HADS-D scores, but higher 1/mean reaction time (1/mRT) score, were found in shift nurses treated with SMG than in those who received placebo, and these effects were associated with changes in salivary melatonin, TNF, IL-1beta, and IL-6 levels.	N-SUCCINYL METHIONINE	145-148	interleukin 1 alpha	Homo sapiens	260-268
32028242-5	2020	And then through transcriptomes screening, a significant down-regulation of NLR pyrin domain containing 3 (Nlrp3), gasdermin D (Gsdmd), andinterleukin-1 beta (IL-1beta) expression were found after BA treatment.	baicalin	197-199	interleukin 1 alpha	Homo sapiens	159-167
32028242-6	2020	Further analysis confirmed that BA could decrease the levels of NLRP3 and GSDMD, as well as the release of IL-1beta and IL-18, resulting in the reduction of pyroptosis.	baicalin	32-34	interleukin 1 alpha	Homo sapiens	107-115
32062076-6	2020	Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1.	cap	9-12	interleukin 1 alpha	Homo sapiens	109-117
32062076-6	2020	Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1.	Acetaminophen	24-28	interleukin 1 alpha	Homo sapiens	109-117
32076940-8	2020	Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs).	rhodioloside	13-16	interleukin 1 alpha	Homo sapiens	89-97
32076940-8	2020	Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs).	Adenosine Triphosphate	138-160	interleukin 1 alpha	Homo sapiens	89-97
32076940-8	2020	Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs).	Adenosine Triphosphate	162-165	interleukin 1 alpha	Homo sapiens	89-97
31974519-6	2020	The production of IL-1beta by THP-1 was also inhibited by ozenoxacin at the concentration of 30 mug ml-1.	ozenoxacin	58-68	interleukin 1 alpha	Homo sapiens	18-26
31999847-0	2020	Higher intakes of flavonoids are associated with lower salivary IL-1beta and maintenance of periodontal health 3 to 4 years after scaling and root planing.	Flavonoids	18-28	interleukin 1 alpha	Homo sapiens	64-72
32090454-4	2020	The target of our following study is to evaluate the protective effects of ATG on IL-1beta-induced human OA chondrocytes and mouse OA model.	arctigenin	75-78	interleukin 1 alpha	Homo sapiens	82-90
31999847-5	2020	RESULTS: Flavonoid intake was inversely associated with PD (p=0.042) and salivary IL-1beta concentration (p=0.015) after adjustment for multiple confounders.	Flavonoids	9-18	interleukin 1 alpha	Homo sapiens	82-90
31999847-9	2020	CONCLUSION: Higher flavonoid intake is associated with lower IL-1beta.	Flavonoids	19-28	interleukin 1 alpha	Homo sapiens	61-69
32264730-0	2020	Treatment with 7% and 10% CO2 enhanced expression of IL-1beta, TNF-alpha, and IL-6 in hypoxic cultures of human whole blood.	Carbon Dioxide	26-29	interleukin 1 alpha	Homo sapiens	53-61
32176389-2	2020	This study aimed to investigate the effect of 17beta-estradiol (E2) on the inflammatory response stimulated by interleukin-1 beta (IL-1beta) in human oral mucosal epithelial cells (hOMECs) and its possible mechanism.	Estradiol	46-62	interleukin 1 alpha	Homo sapiens	131-139
32132181-8	2020	Thus, AmB induced IL-1beta and IL-18 secretions, which are reduced by specific inhibitors of caspase activation (Q-VD) and NLRP3 activation (MCC950).	Amphotericin B	6-9	interleukin 1 alpha	Homo sapiens	18-26
32062019-7	2020	Our findings suggest that high glucose and PA could induce excessive ER stress and apoptosis via promoting the overexpression of GLUT3 and FATP1, and ER stress could suppress BDNF and SYN expression through negatively regulating p38/ERK-CREB pathway and positively regulating NLRP3-IL-1beta pathway, which could be reversed by activated Nrf2-HO-1 pathway.	Glucose	31-38	interleukin 1 alpha	Homo sapiens	282-290
31859422-9	2020	The results showed that loganin repressed the expression and release of IL-6, TNF-alpha, and IL-1beta, and inhibited TLR4/NF-kappaB and JAK/STAT3 signaling pathways in a concentration-dependent manner.	loganin	24-31	interleukin 1 alpha	Homo sapiens	93-101
32062019-7	2020	Our findings suggest that high glucose and PA could induce excessive ER stress and apoptosis via promoting the overexpression of GLUT3 and FATP1, and ER stress could suppress BDNF and SYN expression through negatively regulating p38/ERK-CREB pathway and positively regulating NLRP3-IL-1beta pathway, which could be reversed by activated Nrf2-HO-1 pathway.	Palmitic Acid	43-45	interleukin 1 alpha	Homo sapiens	282-290
32244640-10	2020	However, SDSX16-P10 was found to cause lower levels of cytokine expression than SDSX16-P75 using real-time PCR and flow cytometry, such as IL1beta, IL6, IFN-beta, TNF-alpha, indicating that SDSX16-P10 might inhibit the expression of cytokines.	sdsx16	9-15	interleukin 1 alpha	Homo sapiens	139-146
32234475-5	2020	Dectin-1 also promotes inflammasome-dependent interleukin-1beta (IL-1beta) secretion through leukotriene B4 production.	Leukotriene B4	93-107	interleukin 1 alpha	Homo sapiens	65-73
32244640-10	2020	However, SDSX16-P10 was found to cause lower levels of cytokine expression than SDSX16-P75 using real-time PCR and flow cytometry, such as IL1beta, IL6, IFN-beta, TNF-alpha, indicating that SDSX16-P10 might inhibit the expression of cytokines.	sdsx16-p10	9-19	interleukin 1 alpha	Homo sapiens	139-146
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interleukin 1 alpha	Homo sapiens	154-162
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	tubastatin A	9-12	interleukin 1 alpha	Homo sapiens	132-140
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	Oxidopamine	23-29	interleukin 1 alpha	Homo sapiens	132-140
32091090-6	2020	Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs.	naringin	14-22	interleukin 1 alpha	Homo sapiens	172-180
32244518-8	2020	Cannabidiol inhibited the protein kinase B (AKT) activation, a crucial effector in the IL-1beta/IL-1RI/beta-catenin pathway, indicating that at this point there is crosstalk between IL-1beta and CBD signaling which results in phenotype reversion.	Cannabidiol	0-11	interleukin 1 alpha	Homo sapiens	87-95
32244518-8	2020	Cannabidiol inhibited the protein kinase B (AKT) activation, a crucial effector in the IL-1beta/IL-1RI/beta-catenin pathway, indicating that at this point there is crosstalk between IL-1beta and CBD signaling which results in phenotype reversion.	Cannabidiol	0-11	interleukin 1 alpha	Homo sapiens	182-190
32223750-8	2020	Analysis of mRNA expression was performed to investigate an antagonism of LPS stimulation by melatonin via COX and IL-1 beta induction.	Melatonin	93-102	interleukin 1 alpha	Homo sapiens	115-124
32223750-13	2020	Co-culturing of melatonin with LPS resulted in the reduction of COX-2 and IL-1 beta expression in primary pulpal fibroblasts, indicating that melatonin may play an antagonistic role to LPS infection in pulpal fibroblasts.	Melatonin	16-25	interleukin 1 alpha	Homo sapiens	74-83
32223750-13	2020	Co-culturing of melatonin with LPS resulted in the reduction of COX-2 and IL-1 beta expression in primary pulpal fibroblasts, indicating that melatonin may play an antagonistic role to LPS infection in pulpal fibroblasts.	Melatonin	142-151	interleukin 1 alpha	Homo sapiens	74-83
32223750-15	2020	Melatonin exerted antagonistic activity against LPS-mediated COX-2 and IL-1 beta induction in pulpal fibroblasts, suggesting its therapeutic potential for pulpal inflammation and a possible role of pulpal melatonin in an immunomodulation via functional melatonin receptors expressed in dental pulp.	Melatonin	0-9	interleukin 1 alpha	Homo sapiens	71-80
32218354-5	2020	Vildagliptin is able to limit inflammation by suppression of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway and proinflammatory agents such as TNF-alpha (tumor necrosis factor alpha), IL-1beta (Interleukin-1beta), and IL-8 (Interleukin 8).	Vildagliptin	0-12	interleukin 1 alpha	Homo sapiens	234-242
32230726-7	2020	However, application of exogenous control activators such as Nigericin or ATP to infected cells readily induced NLRP3 inflammasome formation and secretion of high amounts of mature IL-1beta.	Nigericin	61-70	interleukin 1 alpha	Homo sapiens	181-189
32230726-7	2020	However, application of exogenous control activators such as Nigericin or ATP to infected cells readily induced NLRP3 inflammasome formation and secretion of high amounts of mature IL-1beta.	Adenosine Triphosphate	74-77	interleukin 1 alpha	Homo sapiens	181-189
32222695-11	2020	In vitro experiments indicated that DOP increased the LO2 cell viability; prevented LDH release prominently; reduced the secretion of IL-1beta, IL-6, and TNF-alpha; and reversed the expression of IL-1beta, IL-6, TNF-alpha, caspase 1, NLRP3, p-NF-kappaB, and TLR4.	Diethylhexyl Phthalate	36-39	interleukin 1 alpha	Homo sapiens	134-142
32222695-11	2020	In vitro experiments indicated that DOP increased the LO2 cell viability; prevented LDH release prominently; reduced the secretion of IL-1beta, IL-6, and TNF-alpha; and reversed the expression of IL-1beta, IL-6, TNF-alpha, caspase 1, NLRP3, p-NF-kappaB, and TLR4.	Diethylhexyl Phthalate	36-39	interleukin 1 alpha	Homo sapiens	196-204
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	interleukin 1 alpha	Homo sapiens	125-133
32214022-1	2020	The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in human blood in chronic environmental exposure to this metal) on interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) concentrations and the activity and expression of COX-1 and COX-2 in THP-1 macrophages.	Lead	59-61	interleukin 1 alpha	Homo sapiens	192-200
32214022-5	2020	Our results indicate that even low concentrations of Pb cause an increase in production of inflammatory interleukins (IL-1beta and IL-6), increases expression of COX-1 and COX-2, and increases thromboxane B2 and prostaglandin E2 concentration in macrophages.	Lead	53-55	interleukin 1 alpha	Homo sapiens	118-126
32209983-8	2020	IL-1beta secretion did not differ between conditions but was lower 60 min post-glucose ingestion compared to the fasting baseline (main effect of time, p = 0.014).	Glucose	79-86	interleukin 1 alpha	Homo sapiens	0-8
32209983-9	2020	Plasma IL-1beta was detectable in ~80% of samples and showed a decrease from fasting baseline to 60 min in the ketone condition only (condition x time interaction, p = 0.01).	Ketones	111-117	interleukin 1 alpha	Homo sapiens	7-15
32209983-11	2020	Exogenous ketone supplementation may impact plasma IL-1beta, but these findings require confirmation in studies with larger sample sizes.	Ketones	10-16	interleukin 1 alpha	Homo sapiens	51-59
32256501-4	2020	Beryllium exposure induces trafficking of dendritic cells to the lung in a mechanism dependent on MyD88 and IL-1alpha.	Beryllium	0-9	interleukin 1 alpha	Homo sapiens	108-117
32257967-7	2020	Further, the miR-378d mimic suppressed, while its inhibitor enhanced the protein production of IL-1beta, TNF-alpha, IL-6, and Rab10 expression.	mir-378d	13-21	interleukin 1 alpha	Homo sapiens	95-103
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	interleukin 1 alpha	Homo sapiens	125-147
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	4-boronic acid benzophenone	59-63	interleukin 1 alpha	Homo sapiens	125-133
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	interleukin 1 alpha	Homo sapiens	95-103
32265874-7	2020	Furthermore, we found that NaB treatment reduced the production of inflammatory cytokines (IL-1beta, TNF-alpha, and IL-10) and a key anti-apoptotic marker protein Bcl-2 in THP-1 cell infected with M. bovis.	nab	27-30	interleukin 1 alpha	Homo sapiens	91-99
32188443-9	2020	RESULTS: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-alpha and IL-1beta production in human U937 macrophages.	Methylene Chloride	98-113	interleukin 1 alpha	Homo sapiens	185-193
32188443-9	2020	RESULTS: Amongst 14 different leaf extracts investigated, extracts prepared by ultrasonication in dichloromethane and maceration in ethanol were most active in inhibiting TNF-alpha and IL-1beta production in human U937 macrophages.	Ethanol	132-139	interleukin 1 alpha	Homo sapiens	185-193
32188443-10	2020	Further purification led to the isolation of artemetin, casticin, vitexilactone and maslinic acid, and their effects on TNF-alpha and IL-1beta production were evaluated.	artemetin	45-54	interleukin 1 alpha	Homo sapiens	134-142
32188443-11	2020	We report for the first time that artemetin suppressed TNF-alpha and IL-1beta production.	artemetin	34-43	interleukin 1 alpha	Homo sapiens	69-77
32256360-9	2020	The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay.	Uric Acid	59-75	interleukin 1 alpha	Homo sapiens	132-154
32256360-9	2020	The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay.	Uric Acid	77-80	interleukin 1 alpha	Homo sapiens	132-154
32024700-5	2020	In this study, we show that in addition to IL-1beta, PSTPIP2 also negatively regulates pathways governing reactive oxygen species generation by neutrophil NOX2 NADPH oxidase.	NADP	160-165	interleukin 1 alpha	Homo sapiens	43-51
32168763-6	2020	The irreversible inhibitor of TG2 NC9 not only decreased reactive oxygen species production 28-fold, but decreased the concentration of MCP-1, IL-1beta and TNF-alpha 8-, 15- and 61-fold, respectively in the combined ATRA + ATO-treated wild-type NB4 cell culture.	Tretinoin	216-220	interleukin 1 alpha	Homo sapiens	143-151
32024700-5	2020	In this study, we show that in addition to IL-1beta, PSTPIP2 also negatively regulates pathways governing reactive oxygen species generation by neutrophil NOX2 NADPH oxidase.	Oxygen	115-121	interleukin 1 alpha	Homo sapiens	43-51
32164364-5	2020	In SiONPs-stimulated NCI-H292 airway epithelial cells, silibinin treatment effectively suppressed the elevation of the mRNA expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta, which was accompanied by the reduction in the expression of TXNIP, MAPKs, and activator protein-1 (AP-1).	Silybin	55-64	interleukin 1 alpha	Homo sapiens	203-211
32182743-7	2020	Macrophage interaction with CSnp-treated biofilm reduced proinflammatory markers (nitric oxide, TNF-alpha, IL-1beta, and IL-6), increased anti-inflammatory marker (TGF-beta1) and enhanced cell survival and spreading over time (p < 0.01 at 72 h).	csnp	28-32	interleukin 1 alpha	Homo sapiens	107-115
32163856-7	2020	In human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), DEX (250 nM and 500 nM) was found to inhibit the expression of IL-1beta, IL-6, MMP-3, MMP-9, and P-P65 following stimulation with TNF-alpha.	Dexmedetomidine	70-73	interleukin 1 alpha	Homo sapiens	133-141
32057196-4	2020	We identified pathogenic mechanisms of inflammasome activation, including that disease-specific 2-O-sulphated heparan sulphate was essential for priming an IL-1beta response via the Toll-like receptor 4 complex.	Heparitin Sulfate	96-126	interleukin 1 alpha	Homo sapiens	156-164
32196098-6	2020	Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1beta-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels.	pregna-4,17-diene-3,16-dione	55-57	interleukin 1 alpha	Homo sapiens	103-111
32196098-9	2020	GS pretreatment attenuated the phosphorylation of nuclear factor-kappa B induced by IL-1beta.	pregna-4,17-diene-3,16-dione	0-2	interleukin 1 alpha	Homo sapiens	84-92
32182747-8	2020	However, a significant effect was observed in IL1beta (p = 0.011) and IL6 (p = 0.009), which showed significantly lower values after DHA consumption than after placebo ingestion.	Docosahexaenoic Acids	133-136	interleukin 1 alpha	Homo sapiens	46-53
32194991-3	2020	Although metformin reportedly inhibits mature IL-1beta secretion via NLRP3 inflammasome in macrophages of T2DM patients, it remains unclear whether it affects skin inflammation in psoriasis.	Metformin	9-18	interleukin 1 alpha	Homo sapiens	46-54
32155780-8	2020	To reveal the anti-oxidative ability of STC1 in TMSCs themselves or against other cell types, the generation of mitochondrial reactive oxygen species (ROS) in TMSC or ROS-mediated production of interleukin (IL)-1beta from macrophage-like cells were detected.	Reactive Oxygen Species	167-170	interleukin 1 alpha	Homo sapiens	194-216
32146317-0	2020	Theobromine mitigates IL-1beta-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes.	Theobromine	0-11	interleukin 1 alpha	Homo sapiens	22-30
32146317-4	2020	In the current study, we found that theobromine, a constituent of the cacao plant, possesses a preventive effect against interleukin (IL)-1beta-induced chondrocyte dysfunction.	Theobromine	36-47	interleukin 1 alpha	Homo sapiens	121-143
32146317-5	2020	Theobromine ameliorates IL-1beta-induced production of cellular reactive oxygen species (ROS) and inflammatory mediators including cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).	Theobromine	0-11	interleukin 1 alpha	Homo sapiens	24-32
32146317-5	2020	Theobromine ameliorates IL-1beta-induced production of cellular reactive oxygen species (ROS) and inflammatory mediators including cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).	Reactive Oxygen Species	64-87	interleukin 1 alpha	Homo sapiens	24-32
32146317-5	2020	Theobromine ameliorates IL-1beta-induced production of cellular reactive oxygen species (ROS) and inflammatory mediators including cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).	Reactive Oxygen Species	89-92	interleukin 1 alpha	Homo sapiens	24-32
32146317-5	2020	Theobromine ameliorates IL-1beta-induced production of cellular reactive oxygen species (ROS) and inflammatory mediators including cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).	Dinoprostone	160-176	interleukin 1 alpha	Homo sapiens	24-32
32146317-5	2020	Theobromine ameliorates IL-1beta-induced production of cellular reactive oxygen species (ROS) and inflammatory mediators including cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2).	Dinoprostone	178-182	interleukin 1 alpha	Homo sapiens	24-32
32146317-6	2020	The presence of theobromine suppresses IL-1beta-induced inducible nitro oxide synthase (iNOS) expression and cellular nitro oxide (NO) production.	Theobromine	16-27	interleukin 1 alpha	Homo sapiens	39-47
32146317-6	2020	The presence of theobromine suppresses IL-1beta-induced inducible nitro oxide synthase (iNOS) expression and cellular nitro oxide (NO) production.	nitro oxide	66-77	interleukin 1 alpha	Homo sapiens	39-47
32146317-7	2020	Theobromine also suppresses IL-1beta-induced production of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), as well as matrix metalloproteinases (MMP)-3 and MMP-13.	Theobromine	0-11	interleukin 1 alpha	Homo sapiens	28-36
32146317-8	2020	Additionally, theobromine mitigates IL-1beta-induced type II collagen degradation.	Theobromine	14-25	interleukin 1 alpha	Homo sapiens	36-44
32146317-9	2020	Mechanistically, we show that theobromine inhibits IL-1beta-induced IkappaBalpha activation, nuclear factor-kappaB (NF-kappaB) protein p65 accumulation, and transfected NF-kappaB promoter activity, indicating that theobromine suppresses the NF-kappaB pathway in chondrocytes.	Theobromine	30-41	interleukin 1 alpha	Homo sapiens	51-59
32146317-9	2020	Mechanistically, we show that theobromine inhibits IL-1beta-induced IkappaBalpha activation, nuclear factor-kappaB (NF-kappaB) protein p65 accumulation, and transfected NF-kappaB promoter activity, indicating that theobromine suppresses the NF-kappaB pathway in chondrocytes.	Theobromine	214-225	interleukin 1 alpha	Homo sapiens	51-59
32150886-7	2020	The release of IL-1beta, IL-8, MCP-1 and M-CSF proteins was mainly affected in macrophages after metal ion exposure (100 microM), indicating a higher impact on pro-inflammatory activity.	Metals	97-102	interleukin 1 alpha	Homo sapiens	15-23
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	interleukin 1 alpha	Homo sapiens	156-164
32194991-5	2020	This stimulation induced the upregulation of pro-IL-1beta mRNA and protein levels, and subsequently mature IL-1beta secretion, which was inhibited by metformin treatment.	Metformin	150-159	interleukin 1 alpha	Homo sapiens	49-57
32130250-4	2020	We found that 3PO caused a rapid and transient reduction in IL-1beta- and TNF-induced phosphorylation of both IKKalpha/beta and JNK, thus inhibiting signaling through the NFkappaB and the stress-activated kinase pathways.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	14-17	interleukin 1 alpha	Homo sapiens	60-68
32118580-4	2020	In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to CF monocytes showed a significant reduction in IL-18, whereas IL-1beta was only reduced with ivacaftor/tezacaftor.	tezacaftor	175-185	interleukin 1 alpha	Homo sapiens	134-142
32118580-6	2020	Serum IL-18 and TNF decreased significantly with treatments, but IL-1beta only declined following ivacaftor/tezacaftor.	ivacaftor	98-107	interleukin 1 alpha	Homo sapiens	65-73
32118580-8	2020	Ivacaftor/tezacaftor alone showed a significant reduction in IL-1beta and pro-IL-1beta mRNA.	tezacaftor	10-20	interleukin 1 alpha	Homo sapiens	61-69
32118580-6	2020	Serum IL-18 and TNF decreased significantly with treatments, but IL-1beta only declined following ivacaftor/tezacaftor.	tezacaftor	108-118	interleukin 1 alpha	Homo sapiens	65-73
32118580-8	2020	Ivacaftor/tezacaftor alone showed a significant reduction in IL-1beta and pro-IL-1beta mRNA.	ivacaftor	0-9	interleukin 1 alpha	Homo sapiens	61-69
32156136-7	2020	Dexmedetomidine infusion reduced the TNF-alpha, IL-1 level in blood samples and maintained the balance of proportion of CD4+ and CD8+ T-lymphocytes.	Dexmedetomidine	0-15	interleukin 1 alpha	Homo sapiens	48-52
31996020-2	2020	Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1.	Uric Acid	0-9	interleukin 1 alpha	Homo sapiens	116-134
31996020-2	2020	Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1.	Uric Acid	49-54	interleukin 1 alpha	Homo sapiens	116-134
31996020-5	2020	Approach and Results: The secretion of IL-1beta from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid.	Uric Acid	221-230	interleukin 1 alpha	Homo sapiens	39-47
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Methylene Chloride	20-35	interleukin 1 alpha	Homo sapiens	46-54
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Polycyclic Aromatic Hydrocarbons	99-131	interleukin 1 alpha	Homo sapiens	46-54
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Polycyclic Aromatic Hydrocarbons	133-137	interleukin 1 alpha	Homo sapiens	46-54
32007923-5	2020	In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components.	Polycyclic Aromatic Hydrocarbons	245-249	interleukin 1 alpha	Homo sapiens	46-54
31991371-5	2020	The results of our study show that tricetin suppressed oxidized low-density lipoprotein (ox-LDL)-induced expression of pro-inflammatory monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1beta), as well as the generation of reactive oxygen species (ROS).	tricetin	35-43	interleukin 1 alpha	Homo sapiens	198-206
32396972-12	2020	CONCLUSION:  This randomized trial indicated that sodium bicarbonate mouth rinse is effective in decreasing IL-1beta levels and increasing salivary pH favorable for prevention of oral diseases.	Sodium Bicarbonate	50-68	interleukin 1 alpha	Homo sapiens	108-116
32271398-10	2020	VO could reverse the effects of IL-1beta and H2O2 by the PTEN inhibition.	Vanadium(II) oxide	0-2	interleukin 1 alpha	Homo sapiens	32-40
32104285-12	2020	Under LPS treatment, the NF-kappaB pathway inhibitor BAY11-7082 further enhanced the inhibitory effects of rapamycin, but inhibited the promoting effects of 3-MA on the protein expression levels of IL-1beta and caspase-1.	3-(4-methylphenylsulfonyl)-2-propenenitrile	53-63	interleukin 1 alpha	Homo sapiens	198-206
32104285-12	2020	Under LPS treatment, the NF-kappaB pathway inhibitor BAY11-7082 further enhanced the inhibitory effects of rapamycin, but inhibited the promoting effects of 3-MA on the protein expression levels of IL-1beta and caspase-1.	3-methyladenine	157-161	interleukin 1 alpha	Homo sapiens	198-206
32258036-8	2020	The phosphorylation of NR4A1 was increased in human osteoarthritis cartilage, and p38 inhibitor SB203580, JNK inhibitor SP600125 and ERK inhibitor FR180204 could significantly inhibited IL-1beta induced NR4A1 phosphorylation.	SB 203580	96-104	interleukin 1 alpha	Homo sapiens	186-194
32258036-8	2020	The phosphorylation of NR4A1 was increased in human osteoarthritis cartilage, and p38 inhibitor SB203580, JNK inhibitor SP600125 and ERK inhibitor FR180204 could significantly inhibited IL-1beta induced NR4A1 phosphorylation.	FR 180204	147-155	interleukin 1 alpha	Homo sapiens	186-194
32258036-9	2020	Reactivation of NR4A1 by its agonist cytosporone B could inhibit IL-1beta induced chondrocyte inflammation and expression of COX-2, iNOS, MMP3, MMP9, and MMP13.	cytosporone B	37-50	interleukin 1 alpha	Homo sapiens	65-73
31979980-0	2020	Oxymatrine suppresses IL-1beta-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-kappaB signaling pathway.	oxymatrine	0-10	interleukin 1 alpha	Homo sapiens	22-30
31782098-7	2020	The results indicate that pre-treatment with synthesized glitazones have increased the percentage cell viability, protected the cell morphology, and decreased the release of pro-inflammatory cytokines (IL-1beta, TNF-alpha), lipid peroxide (LPO), and nitric oxide (NO) level in LPS intoxicated SH-SY5Y cells.	Thiazolidinediones	57-67	interleukin 1 alpha	Homo sapiens	202-210
31685435-11	2020	CONCLUSION: Serum levels of IL-1alpha and FasL may cause different ocular surface abnormalities in SM-exposed patients.	Mustard Gas	99-101	interleukin 1 alpha	Homo sapiens	28-37
31989795-6	2020	Sodium tanshinone IIA sulfonate decreased the levels of inflammatory factors (IL-1beta, IL-6 and TNF-alpha) in the SH-SY5Y cells.	tanshinone II A sodium sulfonate	0-31	interleukin 1 alpha	Homo sapiens	78-86
32252155-10	2020	CONCLUSION: COX-2 inhibition alters the response of NP cells to IL-1beta, suggesting IL-1beta action on disc cells is mediated at least in part through COX-2 and its prostaglandins.	Prostaglandins	166-180	interleukin 1 alpha	Homo sapiens	64-72
32252155-3	2020	METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125.	Alginates	30-38	interleukin 1 alpha	Homo sapiens	65-73
32252155-3	2020	METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	97-105	interleukin 1 alpha	Homo sapiens	65-73
32252155-6	2020	RESULTS: IL-1beta increased culture media PGE2 and PGF2alpha, but decreased proteoglycan and collagen syntheses as well as mRNA expression of the matrix genes aggrecan, versican, collagen I, and collagen II.	Dinoprostone	42-46	interleukin 1 alpha	Homo sapiens	9-17
32252155-8	2020	COX-2 inhibition initially enhanced and subsequently reduced IL-1beta induced inducible nitric oxide synthase, without altering medium nitrite.	Nitric Oxide	88-100	interleukin 1 alpha	Homo sapiens	61-69
32214297-12	2020	A significant decrease of interleukin (IL)-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, and increased CD4+ and CD4+/CD8+ were observed in the DEX group compared with the SUF group at 24 and 48 hours after surgery (P < 0.05).	Dextromethorphan	146-149	interleukin 1 alpha	Homo sapiens	26-49
32014738-3	2020	MATERIALS AND METHODS: In the current study, we present the use of mass spectrometry as multiplex method of identifying the specific end products of arachidonic and anandamide metabolism by human derived amnion explants treated with either an infectious agent (LPS) or inflammatory mediator (IL-1beta or TNF-alpha).	anandamide	165-175	interleukin 1 alpha	Homo sapiens	292-300
32014738-4	2020	RESULTS: Human amnion tissue explants treated with LPS, IL-1beta, or TNF-alpha increased production of prostaglandin E2 (PGE2; p < 0.05) but decreased PGFM.	Dinoprostone	103-119	interleukin 1 alpha	Homo sapiens	56-64
32014738-4	2020	RESULTS: Human amnion tissue explants treated with LPS, IL-1beta, or TNF-alpha increased production of prostaglandin E2 (PGE2; p < 0.05) but decreased PGFM.	Dinoprostone	121-125	interleukin 1 alpha	Homo sapiens	56-64
32121312-5	2020	Nevertheless, in cell cultures under strong inflammatory activation by poly (I:C), clozapine reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17.	Clozapine	83-92	interleukin 1 alpha	Homo sapiens	115-124
32121312-5	2020	Nevertheless, in cell cultures under strong inflammatory activation by poly (I:C), clozapine reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17.	Clozapine	83-92	interleukin 1 alpha	Homo sapiens	126-134
32121312-6	2020	Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha.	Risperidone	0-11	interleukin 1 alpha	Homo sapiens	55-64
32121312-6	2020	Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha.	Risperidone	0-11	interleukin 1 alpha	Homo sapiens	66-74
32121312-6	2020	Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha.	Haloperidol	16-27	interleukin 1 alpha	Homo sapiens	55-64
32121236-0	2020	Inflammation (IL-1beta) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study .	Vitamin D	47-56	interleukin 1 alpha	Homo sapiens	14-22
32121236-0	2020	Inflammation (IL-1beta) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study .	omega-3 long chain polyunsaturated fatty acids	61-107	interleukin 1 alpha	Homo sapiens	14-22
32111036-6	2020	In addition, SP significantly suppressed the mRNA and protein levels of TNF-alpha, IL-1beta, and IL-6 in TNF-alpha-stimulated NCI-H292 cells.	sp	13-15	interleukin 1 alpha	Homo sapiens	83-91
32101144-7	2020	Large agglomerates of 17 nm TiO2 induced stronger responses than small agglomerates for glutathione depletion, IL-8 and IL-1beta increase, and DNA damage in THP-1, while no effect of agglomeration was observed with 117 nm TiO2.	titanium dioxide	28-32	interleukin 1 alpha	Homo sapiens	120-128
32051249-7	2020	The increase in intracellular H2S levels resulted from the induction of the proinflammatory cytokine, IL-1beta, which is a pathological hallmark of AD.	Deuterium	30-33	interleukin 1 alpha	Homo sapiens	102-110
32106058-8	2020	We also found a decrease in the levels of IL-1beta, IL-6, IL-17, and IL-23 cytokines in the culture supernatant of digoxin treated PBMCs isolated from RA patients.	Digoxin	115-122	interleukin 1 alpha	Homo sapiens	42-50
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	interleukin 1 alpha	Homo sapiens	258-266
32064567-8	2020	There was no statistically significant difference in the cytokine levels between the periods but there was a positive correlation between BOP and IL-1beta (r = 0.49 p = .01) and TNF-alpha (r = 0.39 and p = .05).	bop	138-141	interleukin 1 alpha	Homo sapiens	146-154
31924407-7	2020	Toll-like receptor 4 (TLR4) agonist lipopolysaccharide synergistically enhanced IL-1beta mRNA expression with thrombin, and TLR4 inhibitor TAK-242 abolished thrombin-induced IL-1beta mRNA expression in the presence of slice cultures.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	139-146	interleukin 1 alpha	Homo sapiens	174-182
31648047-5	2020	We found that rifampicin pretreatment suppressed the gene expression of IL-1beta and IL-6 via inhibiting activation of JNK after rotenone induction, but the anti-inflammatory effect of rifampicin was reversed by chloroquine.	Rifampin	14-24	interleukin 1 alpha	Homo sapiens	72-80
31648047-5	2020	We found that rifampicin pretreatment suppressed the gene expression of IL-1beta and IL-6 via inhibiting activation of JNK after rotenone induction, but the anti-inflammatory effect of rifampicin was reversed by chloroquine.	Rotenone	129-137	interleukin 1 alpha	Homo sapiens	72-80
32237452-3	2020	Then, the ethanol extract of Epimedii Folium prepared according to the optimized technological conditions was used to intervene the injury model of chondrocyte induced by interleukin-1 beta(IL-1beta).	Ethanol	10-17	interleukin 1 alpha	Homo sapiens	190-198
32237452-9	2020	This ethanol extract could significantly reduce the early apoptotic rate, late apoptotic and necrotic rate, total apoptotic rate(P<0.05 or P<0.01) of chondrocyte injury model induced by IL-1beta, suggesting that the ethanol extract of Epimedii Folium can inhibit the apoptosis of chondrocytes induced by IL-1beta to a certain extent, which lays a foundation for further study on its prevention and treatment of osteoarthritis.	Ethanol	5-12	interleukin 1 alpha	Homo sapiens	186-194
32237452-9	2020	This ethanol extract could significantly reduce the early apoptotic rate, late apoptotic and necrotic rate, total apoptotic rate(P<0.05 or P<0.01) of chondrocyte injury model induced by IL-1beta, suggesting that the ethanol extract of Epimedii Folium can inhibit the apoptosis of chondrocytes induced by IL-1beta to a certain extent, which lays a foundation for further study on its prevention and treatment of osteoarthritis.	Ethanol	5-12	interleukin 1 alpha	Homo sapiens	304-312
32121312-6	2020	Risperidone and haloperidol both reduced the levels of IL-1alpha, IL-1beta, IL-2, and IL-17, and increased the levels of IL-6, IL-10, INF-gamma, and TNF-alpha.	Haloperidol	16-27	interleukin 1 alpha	Homo sapiens	66-74
32121312-9	2020	Clozapine and CRID3 both reduced the IL-1alpha, IL-1beta, IL-2, and IL-17 levels.	Clozapine	0-9	interleukin 1 alpha	Homo sapiens	37-46
32121312-9	2020	Clozapine and CRID3 both reduced the IL-1alpha, IL-1beta, IL-2, and IL-17 levels.	Clozapine	0-9	interleukin 1 alpha	Homo sapiens	48-56
32121312-9	2020	Clozapine and CRID3 both reduced the IL-1alpha, IL-1beta, IL-2, and IL-17 levels.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	14-19	interleukin 1 alpha	Homo sapiens	37-46
32121312-9	2020	Clozapine and CRID3 both reduced the IL-1alpha, IL-1beta, IL-2, and IL-17 levels.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	14-19	interleukin 1 alpha	Homo sapiens	48-56
32094439-3	2020	BaP1 also induces IL-1beta release, which up-regulates the production of PGE2 at a late stage of the stimulation.	Dinoprostone	73-77	interleukin 1 alpha	Homo sapiens	18-26
32128354-8	2020	Moreover, iNOS, IL-6, IL-8, and COL1A1 expressions were consistently high, and IL-10 protein synthesis steadily increased in IL-1beta-treated chondrocytes under baicalein treated status.	baicalein	161-170	interleukin 1 alpha	Homo sapiens	125-133
32098277-7	2020	Kaempferol stimulated nuclear factor kappa B (NF-kappaB) signaling in lipopolysaccharide (LPS)-treated THP-1 cells, thereby increasing the mRNA expression of interleukin (IL) 1 beta, tumor necrosis factor, and nuclear factor kappa B subunit 1, while IL6 was downregulated.	kaempferol	0-10	interleukin 1 alpha	Homo sapiens	158-181
32154236-8	2020	Among known irritants, high concentrations of methyl violet and methylrosaniline decreased viability, lowered TEER, and increased IL-1alpha secretion in both RhE and FTS models, consistent with irritant properties.	Gentian Violet	46-59	interleukin 1 alpha	Homo sapiens	130-139
32154236-8	2020	Among known irritants, high concentrations of methyl violet and methylrosaniline decreased viability, lowered TEER, and increased IL-1alpha secretion in both RhE and FTS models, consistent with irritant properties.	Gentian Violet	64-80	interleukin 1 alpha	Homo sapiens	130-139
31843963-7	2020	Moreover, IpaJ was efficient in the prevention of NF-kappaB translocation to the nucleus and ultimately interfered with the secretion of the proinflammatory cytokines IL-1beta, IL-6, and IL-8 in infected HeLa cells.	ipaj	10-14	interleukin 1 alpha	Homo sapiens	167-175
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	Bion	12-16	interleukin 1 alpha	Homo sapiens	202-211
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	39-59	interleukin 1 alpha	Homo sapiens	202-211
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	61-64	interleukin 1 alpha	Homo sapiens	202-211
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	Silicon Dioxide	70-76	interleukin 1 alpha	Homo sapiens	202-211
32140425-10	2020	Our results indicate possible effects of PDS on IL-1beta production in human cells and fish survival, calling for more studies on the potential noxious side effects of these compounds.	3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	41-44	interleukin 1 alpha	Homo sapiens	48-56
32252155-10	2020	CONCLUSION: COX-2 inhibition alters the response of NP cells to IL-1beta, suggesting IL-1beta action on disc cells is mediated at least in part through COX-2 and its prostaglandins.	Prostaglandins	166-180	interleukin 1 alpha	Homo sapiens	85-93
32075082-4	2020	We investigated five individually tested alkaloids (coptisine, berberine, chelidonine, chelerythrine, and sanguinarine) as well as C. majus root extract for their effect on the secretion of IL-1beta, IL-8, and TNF-alpha in human polymorphonuclear leukocytes (neutrophils).	coptisine	52-61	interleukin 1 alpha	Homo sapiens	190-198
31887898-2	2020	The results demonstrated that, at high concentrations, carrageenans have substantial ability to modulate PGE2 synthesis and stimulate IL-1beta and IL-6 synthesis.	Carrageenan	55-67	interleukin 1 alpha	Homo sapiens	134-142
32075082-4	2020	We investigated five individually tested alkaloids (coptisine, berberine, chelidonine, chelerythrine, and sanguinarine) as well as C. majus root extract for their effect on the secretion of IL-1beta, IL-8, and TNF-alpha in human polymorphonuclear leukocytes (neutrophils).	Berberine	63-72	interleukin 1 alpha	Homo sapiens	190-198
32075082-6	2020	Sanguinarine was found to be the most potent inhibitor of IL-1beta secretion.	sanguinarine	0-12	interleukin 1 alpha	Homo sapiens	58-66
32051334-2	2020	IL-1beta inhibition has been shown to result in clinical hearing improvement in a small cohort of corticosteroid-resistant patients with AIED.	Adrenal Cortex Hormones	98-112	interleukin 1 alpha	Homo sapiens	0-8
32036721-0	2021	Resveratrol Combined with 17beta-Estradiol Prevents IL-1beta Induced Apoptosis in Human Nucleus Pulposus Via The PI3K/AKT/Mtor and PI3K/AKT/GSK-3beta Pathway.	resveratrol	0-11	interleukin 1 alpha	Homo sapiens	52-60
32036721-12	2021	Conclusion: Combination of Resveratrol and 17beta-estradiol efficiently resisted IL-1beta induced apoptosis of NP cell, mainly through PI3K/AKT/mTOR/caspase-3 and PI3K/AKT/GSK-3beta pathway.	resveratrol	27-38	interleukin 1 alpha	Homo sapiens	81-89
32036721-12	2021	Conclusion: Combination of Resveratrol and 17beta-estradiol efficiently resisted IL-1beta induced apoptosis of NP cell, mainly through PI3K/AKT/mTOR/caspase-3 and PI3K/AKT/GSK-3beta pathway.	Estradiol	43-59	interleukin 1 alpha	Homo sapiens	81-89
32036721-0	2021	Resveratrol Combined with 17beta-Estradiol Prevents IL-1beta Induced Apoptosis in Human Nucleus Pulposus Via The PI3K/AKT/Mtor and PI3K/AKT/GSK-3beta Pathway.	Estradiol	26-42	interleukin 1 alpha	Homo sapiens	52-60
32036721-2	2021	Our previous study revealed that Resveratrol (RSV) combined with 17beta-estradiol (E2) was more effective in cutting down IL-1beta induced NP cell apoptosis via PI3K/AKT pathway.	resveratrol	33-44	interleukin 1 alpha	Homo sapiens	122-130
32036721-2	2021	Our previous study revealed that Resveratrol (RSV) combined with 17beta-estradiol (E2) was more effective in cutting down IL-1beta induced NP cell apoptosis via PI3K/AKT pathway.	resveratrol	46-49	interleukin 1 alpha	Homo sapiens	122-130
32036721-2	2021	Our previous study revealed that Resveratrol (RSV) combined with 17beta-estradiol (E2) was more effective in cutting down IL-1beta induced NP cell apoptosis via PI3K/AKT pathway.	Estradiol	65-81	interleukin 1 alpha	Homo sapiens	122-130
32036721-8	2021	Results: RSV combined with E2 attenuated IL-1beta-induced cell apoptosis and recovered cell viability.	resveratrol	9-12	interleukin 1 alpha	Homo sapiens	41-49
31767149-5	2020	In the work, we discovered that a list of dysregulated proteins involved in energy metabolism and carcinogenesis, including PPARD, IL1-RAP, HNF, S15A2, PCLO, VA0D1, CKLF5, were extremely upregulated in the CD26 + LSCs while some majoring in DNA mismatch repair or related to cell senescence, such as MLH3, NOLC1, were downregulated.	3-(4-(reduced 3-pyridine aldehyde-adenine dinucleotide))pyruvate	135-138	interleukin 1 alpha	Homo sapiens	131-134
32041250-6	2020	Moreover, inflammatory responses induced by gamma irradiation, as demonstrated by increased levels of IL-6, TNF-alpha, and IL-1beta, were also blocked by celastrol.	celastrol	154-163	interleukin 1 alpha	Homo sapiens	123-131
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	interleukin 1 alpha	Homo sapiens	62-66
31965794-7	2020	In addition, FMBP reduced the secretion of inflammatory factor IL-1beta by inhibiting the expression of STAT3 in THP-1 cells.	fmbp	13-17	interleukin 1 alpha	Homo sapiens	63-71
32024542-6	2020	RESULTS: Paroxetine had no impact on LPS-stimulated iNOS, TNF-alpha, and IL-1beta expression, but inhibited M/Lps-induced TNF-alpha and IL-1beta expression in primary astrocytes.	Paroxetine	9-19	interleukin 1 alpha	Homo sapiens	136-144
32015215-5	2020	These effects were reversed by treatment with the early autophagy inhibitor 3-methyl adenine, which suggests HO-1-induced autophagy suppresses IL-1beta-induced apoptosis in NPCs.	3-methyladenine	76-92	interleukin 1 alpha	Homo sapiens	143-151
31855746-6	2020	RESULTS: rDPP dose-dependently reduced the expression of lipopolysaccharide-induced inflammatory genes, such as TNFalpha, IL-1beta, and IL-8, and TNF-alpha protein secretion from the macrophages.	rdpp	9-13	interleukin 1 alpha	Homo sapiens	122-130
31837588-11	2020	BBR (25 uM) treatment in LPS-HDPF could ameliorate cell inflammatory response, presented by reduced expressions of IL-1beta, IL-6 and TNF-alpha, as well as enhanced cell proliferation and miR-21 expression.	Berberine	0-3	interleukin 1 alpha	Homo sapiens	115-123
31848666-3	2020	In the present study, we demonstrated for the first time that estimated human daily DON exposure (25 mug/kg bw) for 30 and 90 days caused low-grade inflammatory infiltration around hepatic centrilobular veins, elevated systemic IL-1beta, IL-6 and TNF-alpha and impaired liver function evidenced by increased serum ALT activity.	deoxynivalenol	84-87	interleukin 1 alpha	Homo sapiens	228-236
31862710-1	2020	In response to extracellular ATP, the purinergic receptor P2X7 mediates various biological processes, including phosphatidylserine (PtdSer) exposure, phospholipid scrambling, dye uptake, ion transport, and IL-1beta production.	Adenosine Triphosphate	29-32	interleukin 1 alpha	Homo sapiens	206-214
30963410-4	2020	RT-PCR findings indicated that selenium supplementation downregulated gene expression of interleukin-1 (IL-1) (P < 0.004) and tumor necrosis factor alpha (TNF-alpha) (P = 0.02) in lymphocytes of patients with PCOS compared with the placebo.	Selenium	31-39	interleukin 1 alpha	Homo sapiens	104-108
30963410-7	2020	Overall, our findings documented that selenium supplementation for 8 weeks to infertile women candidate for IVF improved IL-1, TNF-alpha, and VEGF gene expression, though selenium had no effect on clinical symptoms and, IL-8 and TGF-beta gene expression.	Selenium	38-46	interleukin 1 alpha	Homo sapiens	121-125
31981721-4	2020	We found that co-treatment with JWH133, a selective CB2 receptor agonist, significantly suppressed the MPP+-induced up-regulation of COX-2, iNOS, IL-1beta and TNF-alpha in astrocytes.	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	32-38	interleukin 1 alpha	Homo sapiens	146-154
31981721-4	2020	We found that co-treatment with JWH133, a selective CB2 receptor agonist, significantly suppressed the MPP+-induced up-regulation of COX-2, iNOS, IL-1beta and TNF-alpha in astrocytes.	1-(4-methoxyphenyl)pyridinium	103-106	interleukin 1 alpha	Homo sapiens	146-154
31549730-9	2020	Both IL-1beta and IL-6 responses were augmented by extracellular ADP or ADP-betaS and were abrogated by PSB0739.	Adenosine Diphosphate	65-68	interleukin 1 alpha	Homo sapiens	5-13
31549730-9	2020	Both IL-1beta and IL-6 responses were augmented by extracellular ADP or ADP-betaS and were abrogated by PSB0739.	adenosine 5'-O-(2-thiodiphosphate)	72-81	interleukin 1 alpha	Homo sapiens	5-13
32010254-9	2020	The expression levels of NLRP3, caspase-1 and IL-1beta were inhibited after the addition of autophagy inhibitor 3-MA.	3-methyladenine	112-116	interleukin 1 alpha	Homo sapiens	46-54
32554850-6	2020	This study is aimed to determine if alpha-LA confers protection against NF-kappaB activation, IL-8 expression, and mitochondrial dysfunction in A-T cells which are exposed to the inflammatory cytokine IL-1beta.	Thioctic Acid	36-44	interleukin 1 alpha	Homo sapiens	201-209
32554850-9	2020	As a result, IL-1beta increased NF-kappaB activation, IL-8 expression, intracellular and mitochondrial ROS levels, but decreased MMP and ATP level in A-T cells.	Reactive Oxygen Species	103-106	interleukin 1 alpha	Homo sapiens	13-21
32554850-9	2020	As a result, IL-1beta increased NF-kappaB activation, IL-8 expression, intracellular and mitochondrial ROS levels, but decreased MMP and ATP level in A-T cells.	Adenosine Triphosphate	137-140	interleukin 1 alpha	Homo sapiens	13-21
32554850-10	2020	Pretreatment of A-T cells with alpha-LA inhibited IL-1beta-induced activation of NF-kappaB, IL-8 expression, and mitochondrial dysfunction by reducing ROS levels.	Thioctic Acid	31-39	interleukin 1 alpha	Homo sapiens	50-58
32554850-10	2020	Pretreatment of A-T cells with alpha-LA inhibited IL-1beta-induced activation of NF-kappaB, IL-8 expression, and mitochondrial dysfunction by reducing ROS levels.	Reactive Oxygen Species	151-154	interleukin 1 alpha	Homo sapiens	50-58
31669392-5	2020	Silver and palladium nanoparticles induced autophagy and lysosomal dysfunctions and all metal nanoparticles tested triggered the secretion of IL-1beta through caspase-1 activation.	Silver	0-6	interleukin 1 alpha	Homo sapiens	142-150
31806428-5	2020	Serum IL-1 alpha correlated positively with nephrin, synaptopodin, NAG (P &lt; 0.0001, R2 = 0.68); serum IL-8 correlated directly with synaptopodin and NAG (p &lt; 0.0001, R2 = 0.66); serum IL-18 correlated directly with NAG, KIM-1, and podocalyxin (p &lt; 0.0001, R2=0.647).	synaptopodin	53-65	interleukin 1 alpha	Homo sapiens	6-16
31493768-2	2020	P2X7 receptor (P2X7R) is required for secretion of IL-1beta, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG).	Magnesium	108-117	interleukin 1 alpha	Homo sapiens	51-59
31493768-2	2020	P2X7 receptor (P2X7R) is required for secretion of IL-1beta, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG).	Magnesium	119-121	interleukin 1 alpha	Homo sapiens	51-59
31493768-2	2020	P2X7 receptor (P2X7R) is required for secretion of IL-1beta, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG).	coomassie Brilliant Blue	147-163	interleukin 1 alpha	Homo sapiens	51-59
31493768-2	2020	P2X7 receptor (P2X7R) is required for secretion of IL-1beta, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG).	coomassie Brilliant Blue	165-168	interleukin 1 alpha	Homo sapiens	51-59
31493768-3	2020	We sought to determine whether during inflammation MgSO4 can block endothelial IL-1beta secretion, using an in-vitro model.	Magnesium Sulfate	51-56	interleukin 1 alpha	Homo sapiens	79-87
31493768-5	2020	RESULTS: We demonstrated that MgSO4 is efficacious in blocking IL-1beta-mediated-inflammation in HUVECs, at both the initiation and propagation phases of inflammation.	Magnesium Sulfate	30-35	interleukin 1 alpha	Homo sapiens	63-71
31493768-7	2020	CONCLUSION: LPS-exposure increases IL-1beta production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1beta in both presence and absence of BzATP.	BzATP	127-132	interleukin 1 alpha	Homo sapiens	35-43
31493768-7	2020	CONCLUSION: LPS-exposure increases IL-1beta production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1beta in both presence and absence of BzATP.	Magnesium Sulfate	139-144	interleukin 1 alpha	Homo sapiens	154-162
31493768-7	2020	CONCLUSION: LPS-exposure increases IL-1beta production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1beta in both presence and absence of BzATP.	BzATP	195-200	interleukin 1 alpha	Homo sapiens	35-43
31850631-4	2020	High levels of glucose, reactive oxygen species, and advanced glycation end-products are found in the periodontium of diabetic individuals and lead to increased activation of nuclear factor-kappa B and expression of inflammatory cytokines such as tumor necrosis factor and interleukin-1.	Glucose	15-22	interleukin 1 alpha	Homo sapiens	273-286
32010303-9	2020	The results indicated reduced levels of IL-18 and IL-1beta in the supernatant of the cells of the pulegone groups when compared with those in the LPS + ATP/nigericin group.	pulegone	98-106	interleukin 1 alpha	Homo sapiens	50-58
31669392-5	2020	Silver and palladium nanoparticles induced autophagy and lysosomal dysfunctions and all metal nanoparticles tested triggered the secretion of IL-1beta through caspase-1 activation.	Metals	88-93	interleukin 1 alpha	Homo sapiens	142-150
32010303-13	2020	Furthermore, a high concentration of potassium ions significantly reduced the secretion of IL-1beta after induction/stimulation.	Potassium	37-46	interleukin 1 alpha	Homo sapiens	91-99
32005256-9	2020	Our further findings revealed that treatment with SR9009 inhibited NLRP3 inflammasome activation, inflammatory cytokine (IL-1beta, IL-18, IL-6, and TNF-alpha) production, astrocytosis, microgliosis, and neuronal damage in the hippocampus after SE.	SR9009	50-56	interleukin 1 alpha	Homo sapiens	121-129
32076399-5	2019	IL-1beta in turn induces the secretion of corticotropin-releasing hormone (CRH) and in consequence the secretion of adrenocorticotropic hormone (ACTH) and cortisol, which together with a plethora of further cytokines/chemokines lead to mood disorders.	Hydrocortisone	155-163	interleukin 1 alpha	Homo sapiens	0-8
32082152-10	2019	The results of cellular and molecular experiments showed that JSCBR can effectively reduce the protein expression of ASC, caspase-1, IL-1beta, and NRLP3 in monosodium urate-induced THP-1 cells, which indicated that JSCBR mediated inflammation in gouty arthritis by inhibiting the activation of NOD-like receptor signaling pathway.	Uric Acid	156-172	interleukin 1 alpha	Homo sapiens	133-141
32019154-9	2020	However, only individuals with the TT genotype presented reduced levels of Hcy, TNF-alpha, IL-6, and IL-1beta (p &lt; 0.001).	Thymine	35-37	interleukin 1 alpha	Homo sapiens	101-109
32237476-3	2020	The results showed that compared with MTX alone, Tripterygium Glycosides Tablets combined with MTX could further reduce the expression levels of peripheral blood TNF-alpha(SMD=-8.88,95%CI[-10.77,-6.99],P<0.000 01),IL-1beta(P<0.000 01) and IL-6(SMD=-8.63, 95%CI[-10.57,-6.69], P<0.000 01) in RA patients.	tripterygium glycosides	49-72	interleukin 1 alpha	Homo sapiens	214-222
32021639-13	2020	More importantly, we found that instead of cell apoptosis, PA induced significant pyroptosis, evidenced by remarkably increased mRNA and protein expressions of inflammasome marker NLRP3, Caspase-1 and IL-1beta, as well as cell membrane perforation driving protein GSDMD (P &lt; 0.05).	Palmitic Acid	59-61	interleukin 1 alpha	Homo sapiens	201-209
32013062-6	2020	Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group.	galangin	173-181	interleukin 1 alpha	Homo sapiens	75-98
31991717-4	2020	In our experimental model, main carnosine beneficial effects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta1 (TGF-beta1) and the down-regulation of the expressions of interleukins 1beta and 6 (IL-1beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1).	Carnosine	32-41	interleukin 1 alpha	Homo sapiens	553-561
31973719-9	2020	IL-24 treatment reduced the number of apoptotic cells (0.5x, p &lt; 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H2O2-treated FHs74Int cells.	Water	159-163	interleukin 1 alpha	Homo sapiens	138-142
31536757-6	2020	High PFOS concentrations induced a pro-inflammatory response, measured as increased IL-1alpha/beta release.	perfluorooctane sulfonic acid	5-9	interleukin 1 alpha	Homo sapiens	84-98
31960968-9	2020	RESULTS: We report here that UDCA significantly reduced the IL1beta and TNFalpha-induced expression of IL1, IL6 and IL8 in gingival fibroblasts and the HSC-2 cell line.	Ursodeoxycholic Acid	29-33	interleukin 1 alpha	Homo sapiens	60-67
31960968-9	2020	RESULTS: We report here that UDCA significantly reduced the IL1beta and TNFalpha-induced expression of IL1, IL6 and IL8 in gingival fibroblasts and the HSC-2 cell line.	Ursodeoxycholic Acid	29-33	interleukin 1 alpha	Homo sapiens	60-63
31960968-10	2020	In RAW 264.7 macrophages, UDCA attenuated the expression of IL1alpha, IL1beta and IL6 that was increased by saliva.	Ursodeoxycholic Acid	26-30	interleukin 1 alpha	Homo sapiens	60-68
31960968-10	2020	In RAW 264.7 macrophages, UDCA attenuated the expression of IL1alpha, IL1beta and IL6 that was increased by saliva.	Ursodeoxycholic Acid	26-30	interleukin 1 alpha	Homo sapiens	70-77
31954398-16	2020	Further, chronic cycled ethanol from 4 days in vitro (DIV) to 16DIV caused immediate 2-fold inductions of TNFalpha and IL-1beta that grew to ~4-fold of age-matched control slices by 40DIV.	Ethanol	24-31	interleukin 1 alpha	Homo sapiens	119-127
31805184-8	2020	Systemic administration of C-miR146a oligonucleotide alleviated human monocyte-dependent release of IL-1 and IL-6 in a xenotransplanted B-cell lymphoma model without affecting CD19-specific CAR T-cell antitumor activity.	c-mir146a oligonucleotide	27-52	interleukin 1 alpha	Homo sapiens	100-104
32051736-6	2020	Importantly, we also demonstrate the ability of P2X7R antagonism using A804598 to suppress oxidative stress, expression of interleukin (IL)-1beta, IL-6, MMP-1, MMP-3, MMP-13 as well as activation of the Janus family of tyrosine kinase/signal transducer and activator of transcription (JAK1/STAT3) proinflammatory signaling pathway.	2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine	71-78	interleukin 1 alpha	Homo sapiens	123-145
31747547-8	2020	Furthermore, salidroside remarkably decreased the levels of the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 and impeded the expression of VCAM-1 and ICAM-1 induced by AGEs.	rhodioloside	13-24	interleukin 1 alpha	Homo sapiens	102-110
32047552-6	2020	Our results showed that: (1) Silencing p16 inhibited the proliferation of cervical cancer cells by decreasing the half-life of IL1A mRNA in CDK6 dependent manner; (2) The stabilization of IL1A mRNA was regulated by HuR which could be inactivated by p16/CDK6 mediated phosphorylation at Ser202; (3) IL1A mediated the oncogenic activity of p16 in cervical carcinoma cell lines.	seryl-seryl-seryl-arginine	286-289	interleukin 1 alpha	Homo sapiens	188-192
32047552-6	2020	Our results showed that: (1) Silencing p16 inhibited the proliferation of cervical cancer cells by decreasing the half-life of IL1A mRNA in CDK6 dependent manner; (2) The stabilization of IL1A mRNA was regulated by HuR which could be inactivated by p16/CDK6 mediated phosphorylation at Ser202; (3) IL1A mediated the oncogenic activity of p16 in cervical carcinoma cell lines.	seryl-seryl-seryl-arginine	286-289	interleukin 1 alpha	Homo sapiens	188-192
33463223-6	2020	In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha.	copolymers	39-49	interleukin 1 alpha	Homo sapiens	448-456
33463223-6	2020	In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha.	cpteg	62-67	interleukin 1 alpha	Homo sapiens	448-456
33463223-6	2020	In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha.	sebacic acid	72-74	interleukin 1 alpha	Homo sapiens	448-456
31998284-6	2019	Furthermore, LPC induced pyroptosis in both cells and the activation of the inflammasome with IL-1beta secretion, which was dependent on potassium efflux and lysosomal damage in human monocytes.	Lysophosphatidylcholines	13-16	interleukin 1 alpha	Homo sapiens	94-102
31998284-6	2019	Furthermore, LPC induced pyroptosis in both cells and the activation of the inflammasome with IL-1beta secretion, which was dependent on potassium efflux and lysosomal damage in human monocytes.	Potassium	137-146	interleukin 1 alpha	Homo sapiens	94-102
31998284-7	2019	The present study described the IL-1beta secretion and foam cell formation triggered by LPC via an inflammasome-mediated pathway in human monocytes and endothelial cells.	Lysophosphatidylcholines	88-91	interleukin 1 alpha	Homo sapiens	32-40
31969819-8	2019	Fluoxetine, simvastatin, and resveratrol significantly inhibited this IL-1beta- and TNF-alpha-induced ET-1 production.	Fluoxetine	0-10	interleukin 1 alpha	Homo sapiens	70-78
31969819-8	2019	Fluoxetine, simvastatin, and resveratrol significantly inhibited this IL-1beta- and TNF-alpha-induced ET-1 production.	Simvastatin	12-23	interleukin 1 alpha	Homo sapiens	70-78
31969819-8	2019	Fluoxetine, simvastatin, and resveratrol significantly inhibited this IL-1beta- and TNF-alpha-induced ET-1 production.	Resveratrol	29-40	interleukin 1 alpha	Homo sapiens	70-78
31676289-0	2020	MSU Crystals induce sterile IL-1beta secretion via P2X7 receptor activation and HMGB1 release.	Uric Acid	0-3	interleukin 1 alpha	Homo sapiens	28-36
31536757-7	2020	Moderate concentrations of PFOS suppressed release of the chemokines CXCL8 and CXCL10, whereas both PFOS and PFOA stimulated the release of the pro-inflammatory cytokine IL-1beta in immune stimulated human bronchial epithelial cells.	perfluorooctane sulfonic acid	100-104	interleukin 1 alpha	Homo sapiens	170-178
31536757-7	2020	Moderate concentrations of PFOS suppressed release of the chemokines CXCL8 and CXCL10, whereas both PFOS and PFOA stimulated the release of the pro-inflammatory cytokine IL-1beta in immune stimulated human bronchial epithelial cells.	perfluorooctanoic acid	109-113	interleukin 1 alpha	Homo sapiens	170-178
31574241-8	2020	Nur77 and 6-MP may provide a basis to develop a new treatment for patients who suffer from embryo adhesion dysfunction.Abbreviations: HB-EGF: heparin-binding epidermal growth factor-like growth factor; HOXA10: homeobox A10; NGFI-B: nerve growth factor-induced gene B; RIF: recurrent implantation failure; RPL: recurrent pregnancy loss; 6-MP: 6-mercaptopurine; IGFBP-1: insulin-like growth factor binding protein-1; LIF: leukemia inhibitory factor; IL-1beta: Interleukin - 1beta; CRISPR/Cas9: Clustered Regularly Interspaced Short Palindromic Repeats; AF-1: activation function-1 domain; HIF-1alpha: hypoxia-inducible factor 1alpha; CREB: cAMP response element binding.	Heparin	142-149	interleukin 1 alpha	Homo sapiens	448-456
31692000-0	2020	Interleukin 1alpha and 1beta gene variations are associated with tuberculosis in silica exposed subjects.	Silicon Dioxide	81-87	interleukin 1 alpha	Homo sapiens	0-28
31734849-10	2020	Arsenic could also trigger the induction of GATA4-NF-kappaB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1alpha, IL-1beta, TGF-beta, TNF-alpha, CCL2, PAI-1, and MMP13 mRNA expression.	Arsenic	0-7	interleukin 1 alpha	Homo sapiens	137-146
31676289-2	2020	Few studies have shown that MSU is capable of stimulating the release of IL-1beta in the absence of LPS treatment.	Uric Acid	28-31	interleukin 1 alpha	Homo sapiens	73-81
31676289-10	2020	In the absence of the receptor, or when it was blocked, MSU crystals induced less IL-1beta release and this effect corresponded to the concentration of extracellular ATP.	Uric Acid	56-59	interleukin 1 alpha	Homo sapiens	82-90
31676289-12	2020	CONCLUSIONS: IL-1beta secretion induced by MSU depends on P2X7 receptor activation and involves HMGB1 release.	Uric Acid	43-46	interleukin 1 alpha	Homo sapiens	13-21
31676289-13	2020	GENERAL SIGNIFICANCE: We propose that cell activation caused by MSU crystals induces peritoneal macrophages and THP-1 cells to release ATP and HMGB1, causing IL-1beta secretion via P2X7 receptor activation.	Uric Acid	64-67	interleukin 1 alpha	Homo sapiens	158-166
31676289-13	2020	GENERAL SIGNIFICANCE: We propose that cell activation caused by MSU crystals induces peritoneal macrophages and THP-1 cells to release ATP and HMGB1, causing IL-1beta secretion via P2X7 receptor activation.	Adenosine Triphosphate	135-138	interleukin 1 alpha	Homo sapiens	158-166
31472402-4	2020	TB-KDM individuals exhibit significantly higher levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-1alpha, IL-1beta and IL-6 in comparison to TB-NDM, TB alone and DM alone individuals.	Terbium	0-2	interleukin 1 alpha	Homo sapiens	92-101
32115981-9	2020	RESULTS: Methamphetamine, in very low dose (pM), increased the cell viability and NO production, and decreased cell cytotoxicity, IL-1alpha, IL-1beta, IL-6, INFgamma, and TNFalpha pre-inflammatory cytokines of JEG-3 cell which were exposed to high dose of nicotine, respectively.	Methamphetamine	9-24	interleukin 1 alpha	Homo sapiens	130-139
32115981-9	2020	RESULTS: Methamphetamine, in very low dose (pM), increased the cell viability and NO production, and decreased cell cytotoxicity, IL-1alpha, IL-1beta, IL-6, INFgamma, and TNFalpha pre-inflammatory cytokines of JEG-3 cell which were exposed to high dose of nicotine, respectively.	Methamphetamine	9-24	interleukin 1 alpha	Homo sapiens	141-149
32475915-7	2020	Moreover, Ziyuglycoside II reversed RV-induced downregulation of anti-inflammatory cytokine interleukin (IL)-10 and upregulation of pro-inflammatory factors, such as interferon-gamma (IFN-gamma), IL-1beta, IL-6, and tumor necrosis factor (TNF-alpha).	ziyuglycoside II	10-26	interleukin 1 alpha	Homo sapiens	196-204
32757662-6	2020	Knockdown of TRIM8 attenuated IL-1beta-induced production of inflammatory mediators including nitric oxide and prostaglandin E2.	Nitric Oxide	94-106	interleukin 1 alpha	Homo sapiens	30-38
32757662-6	2020	Knockdown of TRIM8 attenuated IL-1beta-induced production of inflammatory mediators including nitric oxide and prostaglandin E2.	Dinoprostone	111-127	interleukin 1 alpha	Homo sapiens	30-38
32757662-7	2020	The increased expression levels of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1beta-induced chondrocytes were suppressed by TRIM8 knockdown.	Nitric Oxide	45-57	interleukin 1 alpha	Homo sapiens	91-99
31472402-7	2020	TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2  months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment.	Terbium	0-2	interleukin 1 alpha	Homo sapiens	144-153
31472402-7	2020	TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2  months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment.	Terbium	0-2	interleukin 1 alpha	Homo sapiens	237-246
31971835-11	2020	Al activated extracellular signal-regulated kinase 1/2 and nuclear factor-kappa B (NF-kappaB), resulting in mRNA expression of matrix metalloproteinase-9, myosin light-chain kinase, and inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6] in HT-29 cells.	Aluminum	0-2	interleukin 1 alpha	Homo sapiens	270-278
31657968-3	2020	The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis.	Iron	24-28	interleukin 1 alpha	Homo sapiens	226-230
31780370-9	2020	Herein, we found that butyrate could downregulate the production of the inflammatory mediator caused by IL-1beta stimulation in the cell culture model.	Butyrates	22-30	interleukin 1 alpha	Homo sapiens	104-112
32936927-0	2020	RhTSG-6 inhibits IL-1beta-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells.	rhtsg-6	0-7	interleukin 1 alpha	Homo sapiens	17-25
32936927-3	2020	The present study was aimed to explore the functional role of rhTSG-6 in interleukin (IL)-1beta-induced nucleus pulposus (NP) cell model.	rhtsg-	62-68	interleukin 1 alpha	Homo sapiens	73-95
32936927-10	2020	Furthermore, rhTSG-6 also protected NP cells from IL-1beta-induced apoptosis.	rhtsg-6	13-20	interleukin 1 alpha	Homo sapiens	50-58
32936927-11	2020	Mechanically, rhTSG-6 inhibited the activation of members of mitogen-activated protein kinase (MAPK) pathway by blocking the phosphorylation of p38, c-Jun N-terminal kinase (JNK) and ERK in IL-1beta-induced NP cells.	rhtsg-6	14-21	interleukin 1 alpha	Homo sapiens	190-198
32936927-12	2020	CONCLUSIONS: RhTSG-6 can attenuate ECM degradation and apoptosis in IL-1beta-induced NP cells by inhibiting the p38, JNK and ERK pathways, which may contribute to its potential application in the therapy of IDD.	rhtsg-6	13-20	interleukin 1 alpha	Homo sapiens	68-76
33118610-0	2020	The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1beta induced inflammation in vitro osteoarthritis model by regulating PI3K/AKT pathways.	cinnamaldehyde	25-45	interleukin 1 alpha	Homo sapiens	64-72
33118610-0	2020	The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1beta induced inflammation in vitro osteoarthritis model by regulating PI3K/AKT pathways.	cinnamaldehyde	47-50	interleukin 1 alpha	Homo sapiens	64-72
33118610-9	2020	Moreover, the protein levels of IL-8, TNF-alpha, and PGE2 were considerably reduced in IL-1beta-induced chondrocytes treated with different concentrations of TCA.	Dinoprostone	53-57	interleukin 1 alpha	Homo sapiens	87-95
33118610-9	2020	Moreover, the protein levels of IL-8, TNF-alpha, and PGE2 were considerably reduced in IL-1beta-induced chondrocytes treated with different concentrations of TCA.	cinnamaldehyde	158-161	interleukin 1 alpha	Homo sapiens	87-95
33118610-10	2020	Furthermore, the mRNA expression of MMP-13, iNOS, COX-2, and ADAMTS-5 and the phosphorylation of AKT and PI3K were markedly reduced in IL-1beta-induced chondrocytes with the increase in the concentration of TCA.	cinnamaldehyde	207-210	interleukin 1 alpha	Homo sapiens	135-143
33118610-11	2020	CONCLUSIONS: Trans-cinnamaldehyde inhibited the inflammation induced by IL-1beta in chondrocytes through the PI3K/AKT pathway, which suggests that TCA might serve as a potential therapeutic agent for osteoarthritis treatment.	cinnamaldehyde	13-33	interleukin 1 alpha	Homo sapiens	72-80
33118610-11	2020	CONCLUSIONS: Trans-cinnamaldehyde inhibited the inflammation induced by IL-1beta in chondrocytes through the PI3K/AKT pathway, which suggests that TCA might serve as a potential therapeutic agent for osteoarthritis treatment.	cinnamaldehyde	147-150	interleukin 1 alpha	Homo sapiens	72-80
31796383-5	2020	Ethyl pyruvate treatment offered effective protection against lethal endotoxemia and reduced the release of IL-1alpha and IL-1beta.	ethyl pyruvate	0-14	interleukin 1 alpha	Homo sapiens	108-117
31796383-5	2020	Ethyl pyruvate treatment offered effective protection against lethal endotoxemia and reduced the release of IL-1alpha and IL-1beta.	ethyl pyruvate	0-14	interleukin 1 alpha	Homo sapiens	122-130
32345772-6	2020	We found that RSV infection caused a marked increase in interleukin (IL)-6, IL-8, IL-1beta and tumor necrosis factor (TNF)- alpha production and release, which was concentration-dependently attenuated by EPB treatment.	ephedrannin B	204-207	interleukin 1 alpha	Homo sapiens	82-90
31605740-12	2020	Deletion or inhibition of LAT1 efficiently controls IL-23- and IL-1beta-induced phosphatidylinositol 3-kinase/AKT/mTOR activation independent of T-cell receptor signaling.	Phosphatidylinositols	80-100	interleukin 1 alpha	Homo sapiens	63-71
32922479-1	2020	Among recent advances in the identification of anti-inflammation agents, anti-cytokines (like Interleukin-1), related to p38 MAPK families play an important role; Here in we designed new effective and low toxic anti-cytokine agents based on 1-hydroxy-2,4,5-triaryl imidazole derivatives.	1-hydroxy-2,4,5-triaryl imidazole	241-274	interleukin 1 alpha	Homo sapiens	94-107
32922479-2	2020	The reaction of oximoinoketone intermediate with ten different aromatic aldehyde and ammonium acetate in refluxing acetic acid condition give imidazole derived product, the IL-1beta inhibitory assay were performed on Human PBMCs (peripheral blood mononuclear cells) using an enzyme-linked immunosorbent assay (ELISA) kit and then in computational part the binding mode of the best compound was accomplished by docking in Crystal structure of p38 MAP kinase (PDB ID: 1A9U) compared with SB202190 as standard drug.	oximoinoketone	16-30	interleukin 1 alpha	Homo sapiens	173-181
32922479-2	2020	The reaction of oximoinoketone intermediate with ten different aromatic aldehyde and ammonium acetate in refluxing acetic acid condition give imidazole derived product, the IL-1beta inhibitory assay were performed on Human PBMCs (peripheral blood mononuclear cells) using an enzyme-linked immunosorbent assay (ELISA) kit and then in computational part the binding mode of the best compound was accomplished by docking in Crystal structure of p38 MAP kinase (PDB ID: 1A9U) compared with SB202190 as standard drug.	ammonium acetate	85-101	interleukin 1 alpha	Homo sapiens	173-181
32922479-2	2020	The reaction of oximoinoketone intermediate with ten different aromatic aldehyde and ammonium acetate in refluxing acetic acid condition give imidazole derived product, the IL-1beta inhibitory assay were performed on Human PBMCs (peripheral blood mononuclear cells) using an enzyme-linked immunosorbent assay (ELISA) kit and then in computational part the binding mode of the best compound was accomplished by docking in Crystal structure of p38 MAP kinase (PDB ID: 1A9U) compared with SB202190 as standard drug.	Acetic Acid	115-126	interleukin 1 alpha	Homo sapiens	173-181
32922479-2	2020	The reaction of oximoinoketone intermediate with ten different aromatic aldehyde and ammonium acetate in refluxing acetic acid condition give imidazole derived product, the IL-1beta inhibitory assay were performed on Human PBMCs (peripheral blood mononuclear cells) using an enzyme-linked immunosorbent assay (ELISA) kit and then in computational part the binding mode of the best compound was accomplished by docking in Crystal structure of p38 MAP kinase (PDB ID: 1A9U) compared with SB202190 as standard drug.	imidazole	142-151	interleukin 1 alpha	Homo sapiens	173-181
32126555-11	2020	In response to IL-1beta, VSMCs showed a senescence-like phenotype, such as flat and enlarged morphology, increased expression of p21, an increased activity of SA-beta-gal, and increased levels of ROS.	Reactive Oxygen Species	196-199	interleukin 1 alpha	Homo sapiens	15-23
32115603-9	2020	Treatment of HMCs with 5 ng/ml IL-1beta for 24 h significantly increased uptake of Dil-Ox-LDL.	dil-ox-ldl	83-93	interleukin 1 alpha	Homo sapiens	31-39
32115603-13	2020	The imbalance in intracellular cholesterol resulted by IL-1beta can in turn transform HMCs into foam cells and aggravate glomerulosclerosis.	Cholesterol	31-42	interleukin 1 alpha	Homo sapiens	55-63
31791492-5	2020	Moreover, 1 mug/mL to 10 mug/mL carbon particle treatments disrupted the keratinocyte differentiation, and up-regulated inflammation- and psoriasis-related genes, such as IL-1beta, IL-6, CXCL1, CXCL2, CXCL3, CCL20, CXCL8, and S100A7 and S100A9, respectively.	Carbon	32-38	interleukin 1 alpha	Homo sapiens	171-179
31805552-2	2020	In humans, the paired <underline>s</underline>ialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have reciprocal roles in regulating macrophage immune responses, but their interaction with IL-1beta signaling and the inflammasome has not been characterized.	ialic acid	46-56	interleukin 1 alpha	Homo sapiens	250-258
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	Adenosine Triphosphate	64-67	interleukin 1 alpha	Homo sapiens	265-273
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	Nigericin	69-78	interleukin 1 alpha	Homo sapiens	265-273
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	N-Acetylneuraminic Acid	87-98	interleukin 1 alpha	Homo sapiens	265-273
31805552-5	2020	Another leading pathogen, Streptococcus pneumoniae, lacks sialic acid but rather prominently expresses a sialidase, which cleaves sialic acid from macrophages, eliminating cis- interactions with the lectin receptor, thus attenuating Siglec-14 induced IL-1beta secretion.	N-Acetylneuraminic Acid	130-141	interleukin 1 alpha	Homo sapiens	251-259
32581181-7	2020	In pretreated gingival fibroblasts and HSC-2 cells, TCA considerably reduced the expression of IL1beta, IL6, and IL8.	Taurocholic Acid	52-55	interleukin 1 alpha	Homo sapiens	95-102
32612008-7	2020	Moreover, DHP-3 suppressed the mRNA expression of tumor necrosis factor-alpha (TNFalpha), and interleukin-1 beta (IL-1beta).	dhp-3	10-15	interleukin 1 alpha	Homo sapiens	114-122
32126555-14	2020	Resveratrol, an activator of sirtuin-1, postponed the IL-1beta-induced senescence through blocking the NF-kappaB/p53/p21 pathway and attenuated the osteoblastic transition and calcification in VSMCs.	Resveratrol	0-11	interleukin 1 alpha	Homo sapiens	54-62
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Fatty Acids, Omega-3	115-122	interleukin 1 alpha	Homo sapiens	40-48
31753358-6	2020	Both the NT-100 surface and IFN-gamma/LPS stimulation could induce macrophages M1 polarization, indicated by significant upregulation of M1-specific molecules including CD86, iNOS, CCR7 and IL-1beta, without affecting the M2-specific molecules including CD206, Arg1 and IL-10.	nt-100	9-15	interleukin 1 alpha	Homo sapiens	190-198
33508847-1	2020	INTRODUCTION: IL-1beta, a cytokine from the innate immune response, is well known for its proinflammatory effects and stimulating activity on the hypothalamus-pituitary-adrenal axis, leading to the pituitary synthesis of adrenocorticotropic hormone followed by cortisol (and dehydroepiandrosterone - DHEA) release by the adrenal gland.	Hydrocortisone	261-269	interleukin 1 alpha	Homo sapiens	14-22
33508847-1	2020	INTRODUCTION: IL-1beta, a cytokine from the innate immune response, is well known for its proinflammatory effects and stimulating activity on the hypothalamus-pituitary-adrenal axis, leading to the pituitary synthesis of adrenocorticotropic hormone followed by cortisol (and dehydroepiandrosterone - DHEA) release by the adrenal gland.	Dehydroepiandrosterone	275-297	interleukin 1 alpha	Homo sapiens	14-22
33508847-1	2020	INTRODUCTION: IL-1beta, a cytokine from the innate immune response, is well known for its proinflammatory effects and stimulating activity on the hypothalamus-pituitary-adrenal axis, leading to the pituitary synthesis of adrenocorticotropic hormone followed by cortisol (and dehydroepiandrosterone - DHEA) release by the adrenal gland.	Dehydroepiandrosterone	300-304	interleukin 1 alpha	Homo sapiens	14-22
33508847-3	2020	METHOD: We studied the effect of IL-1beta on adrenal steroid production and steroidogenic enzyme RNA expression in the human cell line NCI-H295R.	Steroids	53-60	interleukin 1 alpha	Homo sapiens	33-41
33508847-7	2020	The miRNA profile was modified by IL-1beta treatment to an extent which bears some relationship with the regulatory mechanisms underlying adrenal steroid production.	Steroids	146-153	interleukin 1 alpha	Homo sapiens	34-42
33508847-9	2020	DISCUSSION/CONCLUSIONS: The subtle increase in adrenal steroid production in response to IL-1beta stimulation without any modification in the transcription of the steroidogenic enzymes analyzed suggests an additional inflammatory/anti-inflammatory loop, wherein NR4As receptors may participate.	Steroids	55-62	interleukin 1 alpha	Homo sapiens	89-97
31753397-9	2020	Furthermore, we found that SIRT1 inhibition by nicotinamide completely counteracted the protective effect of DECM on chondrocytes in the presence of IL-1beta or TNF-alpha, indicating that the SIRT1 signaling pathway was involved in the DECM-mediated enhancement of anti-inflammatory properties of chondrocytes.	Niacinamide	47-59	interleukin 1 alpha	Homo sapiens	149-157
31939170-2	2020	The described protocol has been optimized for IL-1 detection in formalin-fixed, paraffin-embedded oral tissue sections by light microscopy.	Formaldehyde	64-72	interleukin 1 alpha	Homo sapiens	46-50
31939170-2	2020	The described protocol has been optimized for IL-1 detection in formalin-fixed, paraffin-embedded oral tissue sections by light microscopy.	Paraffin	80-88	interleukin 1 alpha	Homo sapiens	46-50
31420721-3	2020	Strikingly, compound C, an inhibitor of AMPK, considerably inhibited the secretion of IL-1beta when THP-1 cells were stimulated with LPS plus palmitic acid (PA).	Palmitic Acid	142-155	interleukin 1 alpha	Homo sapiens	86-94
31420721-3	2020	Strikingly, compound C, an inhibitor of AMPK, considerably inhibited the secretion of IL-1beta when THP-1 cells were stimulated with LPS plus palmitic acid (PA).	Palmitic Acid	157-159	interleukin 1 alpha	Homo sapiens	86-94
31705795-0	2020	Allopurinol inhibits excess glucose-induced trophoblast IL-1beta and ROS production.	Allopurinol	0-11	interleukin 1 alpha	Homo sapiens	56-64
32122859-6	2020	Treatment with increasing concentration of OB (25-200 muM) significantly lowered the cell proliferation rate as well as considerably reduced the values of various pro-inflammatory cytokines like IL-1beta, TNF-alpha, IL-6.	obovatol	43-45	interleukin 1 alpha	Homo sapiens	195-203
32454491-7	2020	Furthermore, YiQi GuBen formula suppressed PDGF-BB-induced expression of phosphorylated p65 and the release of inflammatory factors TNF-alpha, IL-1beta, IL-6, and IL-8 in ASMCs.	yiqi guben	13-23	interleukin 1 alpha	Homo sapiens	143-151
31539804-7	2020	AOPPs increased expression of TNF-alpha and IL-1beta in chondrocytes in vitro, which was inhibited by pre-treatment with SB202190 (p38-MAPK inhibitor) or apocynin (NADPH oxidase inhibitor) or NOX4 knockdown by siRNAs.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	121-129	interleukin 1 alpha	Homo sapiens	44-52
31539804-7	2020	AOPPs increased expression of TNF-alpha and IL-1beta in chondrocytes in vitro, which was inhibited by pre-treatment with SB202190 (p38-MAPK inhibitor) or apocynin (NADPH oxidase inhibitor) or NOX4 knockdown by siRNAs.	acetovanillone	154-162	interleukin 1 alpha	Homo sapiens	44-52
31705795-0	2020	Allopurinol inhibits excess glucose-induced trophoblast IL-1beta and ROS production.	Glucose	28-35	interleukin 1 alpha	Homo sapiens	56-64
31705795-2	2020	Using an in vitro model, we previously reported that hyperglycemic levels of glucose induced a pro-inflammatory (IL-1beta, IL-8, RANTES, GRO-alpha), anti-angiogenic (sFlt-1) and anti-migratory profile in a human trophoblast cell line.	Glucose	77-84	interleukin 1 alpha	Homo sapiens	113-121
31705795-3	2020	The IL-1beta response to excess glucose was mediated by uric acid-induced activation of the NLRP3 inflammasome.	Glucose	32-39	interleukin 1 alpha	Homo sapiens	4-12
31705795-3	2020	The IL-1beta response to excess glucose was mediated by uric acid-induced activation of the NLRP3 inflammasome.	Uric Acid	56-65	interleukin 1 alpha	Homo sapiens	4-12
31705795-5	2020	Thus, we sought to test the effects of allopurinol on the IL-1beta and other inflammatory, angiogenic and migratory responses that are triggered in the trophoblast by excess glucose.	Glucose	174-181	interleukin 1 alpha	Homo sapiens	58-66
31705795-6	2020	Under excess glucose conditions, allopurinol significantly inhibited trophoblast secretion of inflammatory IL-1beta; caspase-1 activity; IL-8; RANTES; and GRO-alpha.	Allopurinol	33-44	interleukin 1 alpha	Homo sapiens	107-115
31705795-10	2020	Together, our findings indicate that the xanthine oxidase inhibitor allopurinol inhibited excess glucose-induced trophoblast IL-1beta secretion.	Allopurinol	68-79	interleukin 1 alpha	Homo sapiens	125-133
31705795-10	2020	Together, our findings indicate that the xanthine oxidase inhibitor allopurinol inhibited excess glucose-induced trophoblast IL-1beta secretion.	Glucose	97-104	interleukin 1 alpha	Homo sapiens	125-133
31705795-11	2020	Additionally, through its inhibition of both IL-1beta and ROS production by the trophoblast, allopurinol reduced the additional pro-inflammatory and anti-angiogenic responses to excess glucose.	Allopurinol	93-104	interleukin 1 alpha	Homo sapiens	45-53
31639409-4	2020	It was found that acrolein increased the levels of NLRP3 and cleaved caspase-1, which led to the maturation of interleukin-1beta (IL-1beta).	Acrolein	18-26	interleukin 1 alpha	Homo sapiens	130-138
31639409-5	2020	ELISA assay results, which showed that acrolein increased the secreted IL-1beta, further supported acrolein-induced astrocytic inflammation.	Acrolein	39-47	interleukin 1 alpha	Homo sapiens	71-79
31639409-5	2020	ELISA assay results, which showed that acrolein increased the secreted IL-1beta, further supported acrolein-induced astrocytic inflammation.	Acrolein	99-107	interleukin 1 alpha	Homo sapiens	71-79
32314717-18	2020	HCQ alleviated the destruction in small intestinal epithelium and inhibited the expression levels of TLR9, NF-kappaB and IL-1beta in the serum.	Hydroxychloroquine	0-3	interleukin 1 alpha	Homo sapiens	121-129
33227837-2	2020	The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing (NLRP) 3 inflammasome triggers the activation of inflammatory caspases and maturation of interleukin (IL)-1beta and -18, and has been linked to various human autoinflammatory and autoimmune diseases.	Leucine	31-38	interleukin 1 alpha	Homo sapiens	176-198
32844633-1	2020	THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS).	Serotonin	62-71	interleukin 1 alpha	Homo sapiens	177-185
33268688-6	2020	In addition, using a three-dimensional cultured human epidermis model (LabCyte EPI-MODEL), cherry bark-containing jumihaidokuto extract at 250 or 500 mug/mL significantly suppressed IL-1alpha mRNA expression induced by the application of 0.2 mM BPO.	jumihaidokuto extract	114-135	interleukin 1 alpha	Homo sapiens	182-191
33268688-6	2020	In addition, using a three-dimensional cultured human epidermis model (LabCyte EPI-MODEL), cherry bark-containing jumihaidokuto extract at 250 or 500 mug/mL significantly suppressed IL-1alpha mRNA expression induced by the application of 0.2 mM BPO.	Benzoyl Peroxide	245-248	interleukin 1 alpha	Homo sapiens	182-191
33268688-7	2020	Therefore, cherry bark-containing jumihaidokuto may have suppressed BPO-induced erythema by inhibiting the increase in the IL-1alpha level in the skin.	Benzoyl Peroxide	68-71	interleukin 1 alpha	Homo sapiens	123-132
32844633-1	2020	THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS).	Fluoxetine	91-101	interleukin 1 alpha	Homo sapiens	177-185
32844633-6	2020	Fluoxetine suppressed IL-6 and IL-1beta production in both groups.	Fluoxetine	0-10	interleukin 1 alpha	Homo sapiens	31-39
32844633-7	2020	Blockade of 5-HT2B-receptors with specific antagonist RS 127445 reduced the inhibitory effect of fluoxetine on IL-1beta production in both groups and IL-6 production in healthy subjects.	2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine	54-63	interleukin 1 alpha	Homo sapiens	111-119
32844633-7	2020	Blockade of 5-HT2B-receptors with specific antagonist RS 127445 reduced the inhibitory effect of fluoxetine on IL-1beta production in both groups and IL-6 production in healthy subjects.	Fluoxetine	97-107	interleukin 1 alpha	Homo sapiens	111-119
31882005-2	2019	We investigated the influence of IL-1beta on ubiquitination via its impact on activation of the E3 ligase parkin by either phosphorylated ubiquitin (P-Ub) or NEDD8.	phosphorylated ubiquitin	123-147	interleukin 1 alpha	Homo sapiens	33-41
31888640-7	2019	RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS.	Ticagrelor	9-19	interleukin 1 alpha	Homo sapiens	178-182
31888640-7	2019	RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS.	Clopidogrel	24-35	interleukin 1 alpha	Homo sapiens	178-182
31905600-6	2019	Low-dose epirubicin at non-cytotoxic doses downregulated NLRP3 inflammasome components and reduced the release of cleaved caspase-1, bioactive IL-1beta, and TNF-alpha following NLRP3 activation in a dose-dependent fashion.	Epirubicin	9-19	interleukin 1 alpha	Homo sapiens	143-151
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	interleukin 1 alpha	Homo sapiens	45-53
31835256-5	2019	Pretreatment with caspase-1 inhibitor, WEHD significantly abolished the nicotine-induced colocalization of NLRP3 with Asc, caspase-1 activity, IL-1beta production and cell permeability in podocytes.	Nicotine	72-80	interleukin 1 alpha	Homo sapiens	143-151
31852517-12	2019	In relation to cytokine secretion, the results indicate that lymphocytes were activated by gamma-hexalactone at non-cytotoxic concentrations, involving an increase in the IL-1 levels in all tested concentrations, ranging from approximately 56 to 93%.	4-hexanolide	91-108	interleukin 1 alpha	Homo sapiens	171-175
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	interleukin 1 alpha	Homo sapiens	119-127
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	Nicotine	82-90	interleukin 1 alpha	Homo sapiens	119-127
31631701-9	2019	The levels of inflammatory factors (TNF-alpha, IL-1beta, IL-6 and IL-10) were significantly regulated by silibinin treatment.	Silybin	105-114	interleukin 1 alpha	Homo sapiens	47-55
31831776-7	2019	In the diseased cells, the ERK1/2 inhibitor (PD98059) completely blocked the IL-1beta-induced TGFB1 and partially reduced BMP2 mRNA expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	45-52	interleukin 1 alpha	Homo sapiens	77-85
31866999-7	2019	In the absence of VDR, caspase-1 activation and IL-1beta release are increased in response to LPS-induced inflammation or alum-induced peritoneal inflammation, indicating that VDR is a negative regulator of NLRP3 inflammasome activation in vivo.	aluminum sulfate	122-126	interleukin 1 alpha	Homo sapiens	48-56
31866999-8	2019	In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion.	Vitamin D	13-22	interleukin 1 alpha	Homo sapiens	108-116
31835494-5	2019	Moreover, the elevated expressions of c-Fos and phosphorylated c-Jun induced by interleukin-1beta (IL-1beta) were reversed by TCDCA.	Taurochenodeoxycholic Acid	126-131	interleukin 1 alpha	Homo sapiens	99-107
31081409-6	2019	Triptolide-loaded cubic and hexagonal liquid crystals presented excellent anti-arthritic effects, alleviating paw swelling and inhibiting inflammation by downregulating the levels of TNF-alpha and IL-1beta.	triptolide	0-10	interleukin 1 alpha	Homo sapiens	197-205
31665239-4	2019	Here, we demonstrate that dexamethasone blocks interleukin-1 production in both bone marrow-derived and brain resident macrophage populations following stimulation with lipopolysaccharide and interferon gamma.	Dexamethasone	26-39	interleukin 1 alpha	Homo sapiens	47-60
31665239-5	2019	Additionally, dexamethasone is shown to inhibit downstream effectors of interleukin-1 signalling in both macrophage populations.	Dexamethasone	14-27	interleukin 1 alpha	Homo sapiens	72-85
31665239-10	2019	Collectively, this evidence suggests that interleukin-1 signalling inhibition and dexamethasone treatment share therapeutic efficacies and establishes interleukin-1 signalling as an attractive and specific therapeutic target for the management of glioblastoma-associated cerebral oedema.	Dexamethasone	82-95	interleukin 1 alpha	Homo sapiens	151-164
31377467-6	2019	In in vitro, minocycline reduced cytopathic effects (CPEs), viral protein expressions, viral titers, the levels of interleukin (IL)-6 and IL-8 and relative mRNA expressions of IL-12p40, IL-1beta, and tumor necrosis factor (TNF) after EV71 infection.	Minocycline	13-24	interleukin 1 alpha	Homo sapiens	186-194
31580158-5	2019	Then, RT-PCR was performed to detect the effect of different concentrations of ATP on mRNA expression of IL-1beta and MCP-1 induced by LPS (1 mug/mL) and the TLR4 signaling pathway.	Adenosine Triphosphate	79-82	interleukin 1 alpha	Homo sapiens	105-113
31580158-9	2019	Only low concentration ATP (1, 10 muM) inhibited LPS-induced mRNA expression of IL-1beta and MCP-1.	Adenosine Triphosphate	23-26	interleukin 1 alpha	Homo sapiens	80-88
31689135-2	2019	As IL-1beta can be produced by the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domains-containing protein 3 (NLRP3) inflammasome, this study determined whether RLX targeted the inflammasome to inhibit the profibrotic TGF-beta1/IL-1beta axis in primary human cardiac myofibroblasts (HCMFs) in vitro and in mice with isoproterenol (ISO)-induced cardiomyopathy in vivo.	Leucine	78-85	interleukin 1 alpha	Homo sapiens	3-11
31144313-0	2019	miR-382-3p suppressed IL-1beta induced inflammatory response of chondrocytes via the TLR4/MyD88/NF-kappaB signaling pathway by directly targeting CX43.	mir-382-3p	0-10	interleukin 1 alpha	Homo sapiens	22-30
31144313-5	2019	Meanwhile, miR-382-3p was downregulated in IL-1beta-stimulated chondrocytes.	mir-382-3p	11-21	interleukin 1 alpha	Homo sapiens	43-51
31144313-7	2019	Furthermore, our observations indicated that miR-382-3p inhibited the expression of Toll-like receptor 4 (TLR4), Myeloid differentiation primary response 88 (MyD88) and nuclear factor kappaB (NF-kappaB) in IL-1beta-stimulated chondrocytes, while CX43 overexpression could partly reverse these decreases.	mir-382-3p	45-55	interleukin 1 alpha	Homo sapiens	206-214
31546368-8	2019	Catechol-containing hydrogels present high tissue adhesion strength under wet conditions, support growth, migration and proliferation of hBMSCs, protect cells against oxidative stress damage induce by ROS, and promote down-regulation of the pro-inflammatory cytokine IL-1beta.	catechol	0-8	interleukin 1 alpha	Homo sapiens	267-275
31562254-0	2019	Prostate Tumor Cell-Derived IL1beta Induces an Inflammatory Phenotype in Bone Marrow Adipocytes and Reduces Sensitivity to Docetaxel via Lipolysis-Dependent Mechanisms.	Docetaxel	123-132	interleukin 1 alpha	Homo sapiens	28-35
31562254-5	2019	We further show that the enhanced activity of the IL1beta/COX-2/MCP-1 axis and a resulting increase in PGE2 production by adipocytes coincide with augmented hypoxia signaling and activation of prosurvival pathways in tumor cells, revealing a potential mechanism of chemoresistance.	Dinoprostone	103-107	interleukin 1 alpha	Homo sapiens	50-57
31801206-6	2019	The treatment with CBD downregulates the pro-inflammatory pathway mediated by the IL-1 family, including its receptor while MOR is less efficient.	Cannabidiol	19-22	interleukin 1 alpha	Homo sapiens	82-86
31852644-6	2019	RESULTS: Compared with the normal control cells, menthol- treated cells showed significantly increased TNF-alpha, IL-1beta, and p-mTOR expression and elevated intracellular Ca2+ concentration (P < 0.05), and the rapamycin-treated cells exhibited significantly decreased p-mTOR expression (P < 0.05).	Menthol	49-56	interleukin 1 alpha	Homo sapiens	114-122
31885820-9	2019	Moreover, alpha-LA has mechanisms of epigenetic regulation in genes related to the expression of various inflammatory mediators, such PGE2, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6.	Thioctic Acid	10-18	interleukin 1 alpha	Homo sapiens	164-172
32245308-0	2019	A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1beta and TNF-alpha in Patients with Multiple Sclerosis.	Melatonin	60-69	interleukin 1 alpha	Homo sapiens	89-97
32245308-11	2019	However, the level of IL-1beta was significantly reduced in the treatment group compared to the control group, indicating that melatonin decreases this inflammatory substance.	Melatonin	127-136	interleukin 1 alpha	Homo sapiens	22-30
31885670-11	2019	In addition, molecular docking simulation indicated that CSF2, IL1beta, TNF, and IL6 had good binding activity with the corresponding compounds (degree > 10).The 6 compounds (degree >= 5) of HS and essential oil had good interaction with 5 or more targets.	hassio	191-193	interleukin 1 alpha	Homo sapiens	63-70
31885670-11	2019	In addition, molecular docking simulation indicated that CSF2, IL1beta, TNF, and IL6 had good binding activity with the corresponding compounds (degree > 10).The 6 compounds (degree >= 5) of HS and essential oil had good interaction with 5 or more targets.	Oils, Volatile	198-211	interleukin 1 alpha	Homo sapiens	63-70
31766427-6	2019	RESULTS: The expression of several genes involved in the cell cycle regulation, migration, inflammation, phosphatidylinositol 3-kinase (PI3K) and mitogen activated kinase-like protein (MAPK) pathway were found to be modulated including CCNB1, TWIST1, MMP14, TERT, AKT1, PTPRR, FOS and IL1A.	Phosphatidylinositols	105-125	interleukin 1 alpha	Homo sapiens	285-289
34055311-5	2019	Astilbin also inhibited the I/R-induced upregulation of pro-inflammatory mediators (TNFalpha, IL-1beta, IL-6).	astilbin	0-8	interleukin 1 alpha	Homo sapiens	94-102
31739564-8	2019	At higher DON dosage, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha mRNA levels were elevated in the intestinal tissues.	deoxynivalenol	10-13	interleukin 1 alpha	Homo sapiens	22-44
33693087-7	2019	In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion.	Uric Acid	16-19	interleukin 1 alpha	Homo sapiens	116-138
31323526-5	2019	RESULTS: The CSF levels of all cytokines investigated except for IL-1alpha were significantly higher in aSAH compared to controls in the first seven days of ictus.	asah	104-108	interleukin 1 alpha	Homo sapiens	65-74
31323526-6	2019	CSF levels of IL-1alpha (p = 0.014), IL-18 (p = 0.016), IL-6 (p = 0.0006) and IL-8 (p = 0.006) showed significant increases in the days following aSAH.	asah	146-150	interleukin 1 alpha	Homo sapiens	14-23
31618972-13	2019	The presence of at least one IL1A -889T allele in combination with APOEepsilon4+ was associated with a lower risk of AD (OR 2.24, p = 0.047) than the carriage of APOEepsilon4+ alone (OR 2.70, p = 0.015).	apoeepsilon4+	162-175	interleukin 1 alpha	Homo sapiens	29-33
31525456-5	2019	We demonstrated that ghrelin exerts an immunomodulatory effect over LPS-activated peritoneal macrophages, as evidenced by inhibition of TNF-alpha and IL-1beta secretion and increased IL-12 production.	Ghrelin	21-28	interleukin 1 alpha	Homo sapiens	150-158
31407195-12	2019	The levels of plasma inflammatory markers were significantly decreased in BA group after 7 days of intervention in TNF-alpha, IL-1beta, IL-6, IL-8, and PGE2.	boswellic acid	74-76	interleukin 1 alpha	Homo sapiens	126-134
31509298-0	2019	Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1beta production to beta-glucan ligands in a TLR-independent manner.	beta-Glucans	91-102	interleukin 1 alpha	Homo sapiens	68-76
31509298-3	2019	Here, we show that activation of DCs with fungal-associated beta-glucan ligands induces acute glycolytic reprogramming that supports the production of IL-1beta and its secretion subsequent to NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation.	beta-Glucans	60-71	interleukin 1 alpha	Homo sapiens	151-159
31493545-6	2019	It was found as expected that AgNP induced significant release of IL-1beta, IL-6, IL-8 and TNF-alpha in THP1 monocytes more than the basal level.	agnp	30-34	interleukin 1 alpha	Homo sapiens	66-74
31493545-9	2019	However, both AgNP and Lipo-AgNP suppressed IL-1beta and TNF-alpha release in LPS-stimulated THP1 monocytes and LPS-stimulated or unstimulated TDM respectively.	agnp	14-18	interleukin 1 alpha	Homo sapiens	44-52
31493545-9	2019	However, both AgNP and Lipo-AgNP suppressed IL-1beta and TNF-alpha release in LPS-stimulated THP1 monocytes and LPS-stimulated or unstimulated TDM respectively.	lipo-agnp	23-32	interleukin 1 alpha	Homo sapiens	44-52
31852644-8	2019	Compared with the menthol-treated cells, the cells treated with both menthol and rapamycin showed significantly decreased TNF- alpha, IL-1beta, and p-mTOR expression and obviously lowered intracellular Ca2+ concentration (P < 0.05).	Menthol	69-76	interleukin 1 alpha	Homo sapiens	134-142
31852644-8	2019	Compared with the menthol-treated cells, the cells treated with both menthol and rapamycin showed significantly decreased TNF- alpha, IL-1beta, and p-mTOR expression and obviously lowered intracellular Ca2+ concentration (P < 0.05).	Sirolimus	81-90	interleukin 1 alpha	Homo sapiens	134-142
31852644-9	2019	CONCLUSIONS: Menthol promotes the expressions of airway inflammationrelated factors IL-1beta and TNF-alpha possibly by activating mTOR to cause the increase of intracellular Ca2+ concentration.	Menthol	13-20	interleukin 1 alpha	Homo sapiens	84-92
31766400-8	2019	Independent of diagnosis, there was a significant curvilinear association between cotinine and IL-1beta (p = 0.002) reflecting no association for cotinine levels <5 ng/mL and a positive association for >5 ng/mL.	Cotinine	82-90	interleukin 1 alpha	Homo sapiens	95-103
31827706-5	2019	Genetic and pharmacological overexpression of KLF2 suppressed IL-1beta-induced apoptosis and matrix degradation through the suppression of reactive oxygen species (ROS) production.	Reactive Oxygen Species	139-162	interleukin 1 alpha	Homo sapiens	62-70
31827706-5	2019	Genetic and pharmacological overexpression of KLF2 suppressed IL-1beta-induced apoptosis and matrix degradation through the suppression of reactive oxygen species (ROS) production.	Reactive Oxygen Species	164-167	interleukin 1 alpha	Homo sapiens	62-70
31310722-8	2019	In patients with airway disease, concentrations of IL-1ss, IL-6 and IL-8, but also IL-5 were significantly increased in nasal secretion samples during PM high days; a similar pattern was demonstrated in chronically inflamed sinonasal tissue ex vivo after exposure to PM2.5 over 24 and 48h.	[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE	267-270	interleukin 1 alpha	Homo sapiens	51-55
31798452-10	2019	Curcumin, flavocoxid and beta-caryophyllene suppressed IL-1beta expression with different IC50.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	55-63
31798452-10	2019	Curcumin, flavocoxid and beta-caryophyllene suppressed IL-1beta expression with different IC50.	flavocoxid	10-20	interleukin 1 alpha	Homo sapiens	55-63
31798452-10	2019	Curcumin, flavocoxid and beta-caryophyllene suppressed IL-1beta expression with different IC50.	caryophyllene	25-43	interleukin 1 alpha	Homo sapiens	55-63
31411059-12	2019	mRNA expression of proinflammatory and profibrotic factors (TNF-alpha, IL-1, IL-8, MMP3) was elevated by hyperoxia or etoposide.	Etoposide	118-127	interleukin 1 alpha	Homo sapiens	71-75
31518789-0	2019	A sensitive and selective approach for detection of IL 1alpha cancer biomarker using disposable ITO electrode modified with epoxy-substituted polythiophene polymer.	epoxy-substituted polythiophene polymer	124-163	interleukin 1 alpha	Homo sapiens	52-61
31518789-1	2019	A highly sensitive and label-free electrochemical immunosensor for sensitive detection of interleukin 1alpha cancer biomarker was described by using epoxy-substituted polythiophene polymer modified disposable indium tin oxide electrode.	epoxy-substituted polythiophene	149-180	interleukin 1 alpha	Homo sapiens	90-108
31518789-1	2019	A highly sensitive and label-free electrochemical immunosensor for sensitive detection of interleukin 1alpha cancer biomarker was described by using epoxy-substituted polythiophene polymer modified disposable indium tin oxide electrode.	indium tin oxide	209-225	interleukin 1 alpha	Homo sapiens	90-108
31518789-2	2019	This conjugated polymer was synthesized to fabricate this immunosensor for the first time and it offered a good biosensing platform for anti-IL 1alpha antibody immobilization due to epoxy groups present on the side groups of the polymer.	Polymers	16-23	interleukin 1 alpha	Homo sapiens	141-150
31518789-2	2019	This conjugated polymer was synthesized to fabricate this immunosensor for the first time and it offered a good biosensing platform for anti-IL 1alpha antibody immobilization due to epoxy groups present on the side groups of the polymer.	Polymers	229-236	interleukin 1 alpha	Homo sapiens	141-150
31518789-3	2019	Furthermore, the epoxy-substituted polythiophene polymer coated indium tin oxide electrode was used for the determination of IL 1alpha antigen for the first time.	polythiophene	35-48	interleukin 1 alpha	Homo sapiens	125-134
31518789-3	2019	Furthermore, the epoxy-substituted polythiophene polymer coated indium tin oxide electrode was used for the determination of IL 1alpha antigen for the first time.	indium tin oxide	64-80	interleukin 1 alpha	Homo sapiens	125-134
31761984-2	2019	strain M3 and Bacillus megaterium strain 8/75-1 isolated from permafrost formations, as well as a medicinal Bacillus cereus strain IP5832 on the secretion of TNFalpha, IL-1beta, and IL-10 by mononuclear cells of human peripheral blood depending on the temperature of bacteria culturing (-16oC, -5oC, and 42oC) were studied.	ip5832	131-137	interleukin 1 alpha	Homo sapiens	168-176
31659097-9	2019	These findings confirm our previous work, specifically for the TNFalpha-evoked spike in IL1A vs. untreated controls [+21-fold change (FC), p&lt;0.0001] being attenuated by apigenin in the presence of TNFa (-15 FC vs. TNFalpha, p&lt;0.0001).	Apigenin	172-180	interleukin 1 alpha	Homo sapiens	88-92
31994643-0	2019	The effect of naproxen patches on relieving orthodontic pain by evaluation of VAS and IL-1beta inflammatory factor: a split-mouth study.	Naproxen	14-22	interleukin 1 alpha	Homo sapiens	86-94
31994643-2	2019	Objective: The present study aimed to compare the efficacy of naproxen patches in pain control during orthodontic tooth separation, by means of visual analogue scale (VAS) and interleukin 1beta (IL-1beta) levels in gingival crevicular fluid (GCF).	Naproxen	62-70	interleukin 1 alpha	Homo sapiens	195-203
31994643-8	2019	Significant differences were found in pain scores (p&lt; 0.0001) and IL-1beta levels (p= 0.047) between naproxen and placebo groups.	Naproxen	104-112	interleukin 1 alpha	Homo sapiens	69-77
31994643-10	2019	IL-1beta levels were lower for the patients using naproxen patches only 1 hour after separation (p= 0.047).	Naproxen	50-58	interleukin 1 alpha	Homo sapiens	0-8
31994643-12	2019	CONCLUSION: In the light of VAS scores and IL-1beta levels, naproxen patches reduced the pain caused by separator placement.	Naproxen	60-68	interleukin 1 alpha	Homo sapiens	43-51
31520995-7	2019	Using this IL-1beta-induced chondrocyte injury model, we found that upregulation of miR-27a suppressed articular cartilage degradation, the reactive oxygen species (ROS) production and inflammatory response as reflected by reductions in pro-inflammatory cytokines, including interleukin (IL)-6 and IL-8 and tumor necrosis factor (TNF)-alpha.	Reactive Oxygen Species	140-163	interleukin 1 alpha	Homo sapiens	11-19
31520995-7	2019	Using this IL-1beta-induced chondrocyte injury model, we found that upregulation of miR-27a suppressed articular cartilage degradation, the reactive oxygen species (ROS) production and inflammatory response as reflected by reductions in pro-inflammatory cytokines, including interleukin (IL)-6 and IL-8 and tumor necrosis factor (TNF)-alpha.	Reactive Oxygen Species	165-168	interleukin 1 alpha	Homo sapiens	11-19
30856080-10	2019	These studies demonstrated that vitamin E, especially tocotrienol, was able to alleviate IL-1, IL-6, RANKL, iNOS and hs-CRP levels in relation to bone metabolism.	Vitamin E	32-41	interleukin 1 alpha	Homo sapiens	89-93
30856080-10	2019	These studies demonstrated that vitamin E, especially tocotrienol, was able to alleviate IL-1, IL-6, RANKL, iNOS and hs-CRP levels in relation to bone metabolism.	Tocotrienols	54-65	interleukin 1 alpha	Homo sapiens	89-93
31880211-6	2019	Serum IL-1beta, IL-6, and TNF-alpha concentrations significantly decreased for hydrocortisone group at day 7 (all p < .01).	Hydrocortisone	79-93	interleukin 1 alpha	Homo sapiens	6-14
31671764-5	2019	Our results revealed that stybenpropol A reduced soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta) expression by ELISA, inhibited apoptosis, and accelerated nitric oxide (NO) release in TNF-alpha-treated HUVECs.	stybenpropol a	26-40	interleukin 1 alpha	Homo sapiens	205-213
31650795-11	2019	On the other hand, the beta-caryophyllene group showed significant improvement in nausea (p=0.025) and epigastric pain (p=0.018), as well as a decrease in the serum IL-1beta levels (p=0.038).	caryophyllene	23-41	interleukin 1 alpha	Homo sapiens	165-173
31302420-6	2019	Inhibition of miR-103 suppressed production of the catabolic factors and pro-inflammatory cytokines induced by IL-1beta in chondrocytes.	mir-103	14-21	interleukin 1 alpha	Homo sapiens	111-119
31302424-3	2019	Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation.	Leucine	30-37	interleukin 1 alpha	Homo sapiens	251-259
31271646-8	2019	KEY RESULTS: Treatment of macrophages with probenecid or AZ11645373 in vitro diminished NLRP3 inflammasome-dependent IL-1beta secretion.	Probenecid	43-53	interleukin 1 alpha	Homo sapiens	117-125
31271646-8	2019	KEY RESULTS: Treatment of macrophages with probenecid or AZ11645373 in vitro diminished NLRP3 inflammasome-dependent IL-1beta secretion.	AZ 11645373	57-67	interleukin 1 alpha	Homo sapiens	117-125
31377467-7	2019	The levels of TNF, IL-1beta, IL-6, and IL-8 decreased with a single dose of minocycline in EV71-infected THP-1 cells.	Minocycline	76-87	interleukin 1 alpha	Homo sapiens	19-27
31505164-11	2019	E804 was very potent in suppressing many pro-inflammatory genes, including il1a, il1b, il12a, ptgs2, tlr4, and others.	CHEMBL1276317	0-4	interleukin 1 alpha	Homo sapiens	75-79
31473434-7	2019	We found high glucose could increase Propidium Iodide (PI) positive cells and elevate release of lactate dehydrogenase (LDH), Interleukin 1 beta (IL-1beta) and Interleukin 18 (IL-18); protein levels of GSDMD, GSDMD N-terminal domain (GSDMD-N) and cleaved-caspase-1 were also elevated.	Glucose	14-21	interleukin 1 alpha	Homo sapiens	146-154
31352259-8	2019	Mediation analysis was used to understand the relationship between urinary total hydroxynaphthalene (SigmaOHNa) and interleukin (IL)-1beta through seven platelet indices, as mediator variables.	Naphthols	81-99	interleukin 1 alpha	Homo sapiens	116-138
31352259-8	2019	Mediation analysis was used to understand the relationship between urinary total hydroxynaphthalene (SigmaOHNa) and interleukin (IL)-1beta through seven platelet indices, as mediator variables.	sigmaohna	101-110	interleukin 1 alpha	Homo sapiens	116-138
31632288-6	2019	We found that IL-1alpha was highly increased when AIM2 was activated from Poly dA:dT in exacerbated, but not in stable, COPD-derived PBMCs.	poly(dA)	74-81	interleukin 1 alpha	Homo sapiens	14-23
31632288-7	2019	To note, the release of IL-1alpha after the stimulation of AIM2 in PBMCs obtained from stable (hospitalized) COPD patients was not higher from the basal conditions, though it was still as high as that observed for Poly dA:dT-stimulated PBMCs obtained from exacerbated patients.	poly(dA)	214-221	interleukin 1 alpha	Homo sapiens	24-33
31593984-2	2019	Methods: The effect of curcumin on interleukin (IL)-1beta induced-proinflammatory cytokine production was determined using quantitative real-time PCR, enzyme-linked immunosorbent assay (ELISA), and Western blot analysis.	Curcumin	23-31	interleukin 1 alpha	Homo sapiens	35-57
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	interleukin 1 alpha	Homo sapiens	84-92
31593984-8	2019	Curcumin significantly suppressed IL-1beta-induced phosphorylated extracellular signal-regulated kinase, Akt, c-Jun NH(2)-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells, p65 proteins and stimulated beta-catenin translocation into nucleus during adipogenesis.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	34-42
31243816-5	2019	In addition, DEX prevented nuclear factor-kappa B (NF-kappaB) activation and I-kappa B (IkappaB) phosphorylation, as well as the expressions of NLRP3 inflammasome-associated protein and downstream IL-18 and IL-1beta.	Dexmedetomidine	13-16	interleukin 1 alpha	Homo sapiens	207-215
31348843-10	2019	Prostate cancer cells increased the expression of interleukin1beta (IL1beta), IL10, and IL6 in monocytes which was inhibited by galiellalactone.	galiellalactone	128-143	interleukin 1 alpha	Homo sapiens	68-75
31577702-1	2019	BACKGROUND: The aim of this study was to investigate the role of n-acetyl cysteine (NAC) in the lipopolysaccharide (LPS)-mediated induction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) synthesis by human periodontal ligament fibroblast cells (hPDLFs).	Acetylcysteine	65-82	interleukin 1 alpha	Homo sapiens	206-214
31577702-1	2019	BACKGROUND: The aim of this study was to investigate the role of n-acetyl cysteine (NAC) in the lipopolysaccharide (LPS)-mediated induction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) synthesis by human periodontal ligament fibroblast cells (hPDLFs).	Acetylcysteine	84-87	interleukin 1 alpha	Homo sapiens	206-214
31577702-2	2019	In addition, we aimed to determine the involvement of the nuclear factor-kappa B (NF-kappaB) pathway in any changes in IL-1beta and TNF-alpha expression observed in response to LPS and NAC.	Acetylcysteine	185-188	interleukin 1 alpha	Homo sapiens	119-127
31577702-13	2019	CONCLUSION: NAC inhibits the LPS-mediated synthesis of tumor TNF-alpha and IL-1beta in hPDLFs, through the NF-kappaB pathway.	Acetylcysteine	12-15	interleukin 1 alpha	Homo sapiens	75-83
31260749-6	2019	In response to a TNFalpha and IL-1-beta challenge, DHA clearly reduced many COX-derived pro-inflammatory oxylipins, yet to a minor extent when compared to hydrocortisone.	Docosahexaenoic Acids	51-54	interleukin 1 alpha	Homo sapiens	30-39
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Pentosephosphates	58-75	interleukin 1 alpha	Homo sapiens	220-228
32274480-0	2019	[Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1beta and IL-17F in patients with early peri-implant soft tissue inflammation].	dimethylamine tetracycline	12-38	interleukin 1 alpha	Homo sapiens	86-94
32274480-0	2019	[Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1beta and IL-17F in patients with early peri-implant soft tissue inflammation].	Polyphenols	57-68	interleukin 1 alpha	Homo sapiens	86-94
31339859-4	2019	Results Under basal conditions, IL-1beta and IL-6 production was enhanced by BPA in a dose-dependent manner.	bisphenol A	77-80	interleukin 1 alpha	Homo sapiens	32-40
31339859-8	2019	Conclusion BPA may increase placental inflammation by promoting IL-1beta and IL-6 but inhibiting sgp130.	bisphenol A	11-14	interleukin 1 alpha	Homo sapiens	64-72
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Carbon	123-129	interleukin 1 alpha	Homo sapiens	220-228
31420217-5	2019	Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1beta production.	S-Adenosylmethionine	17-20	interleukin 1 alpha	Homo sapiens	144-152
31420217-5	2019	Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1beta production.	S-Adenosylhomocysteine	64-86	interleukin 1 alpha	Homo sapiens	144-152
31420217-5	2019	Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1beta production.	Lysine	115-121	interleukin 1 alpha	Homo sapiens	144-152
31514274-9	2019	RESULTS: Cells treated with SSZ exhibited a decreased IL-1beta production after inflammasome and TLR stimulation, as well as regulation of inflammasome-related genes, in both people with HIV and healthy individuals.	Sulfasalazine	28-31	interleukin 1 alpha	Homo sapiens	54-62
31660068-0	2019	Tailored Black Phosphorus for Erythrocyte Membrane Nanocloaking with Interleukin-1alpha siRNA and Paclitaxel for Targeted, Durable, and Mild Combination Cancer Therapy.	Phosphorus	15-25	interleukin 1 alpha	Homo sapiens	69-87
31407890-7	2019	Concentrations of interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha in macrophage supernatant increased following 100 mug/mL silica exposure for 24 h. Treatment of AMs with 500 muM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface.	Silicon Dioxide	143-149	interleukin 1 alpha	Homo sapiens	18-40
31383786-0	2019	LncRNA SNHG1 alleviates IL-1beta-induced osteoarthritis by inhibiting miR-16-5p-mediated p38 MAPK and NF-kappaB signaling pathways.	mir-16-5p	70-79	interleukin 1 alpha	Homo sapiens	24-32
31383786-6	2019	What is more, miR-16-5p overexpression reversed SNHG1-inhibited aberrant catabolism and inflammation triggered by IL-1beta stimulation.	mir-16-5p	14-23	interleukin 1 alpha	Homo sapiens	114-122
31383786-8	2019	Taken together, the results of our studies illuminate that SNHG1 alleviates the inflammation of IL-1beta-induced OA through the activation of miR-16-5p-mediated p38MAPK and NF-kappaB signaling pathway.	mir-16-5p	142-151	interleukin 1 alpha	Homo sapiens	96-104
31411318-5	2019	In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-8, IL-18, and TNFalpha, and the secretion of IL-6.	hescs	26-31	interleukin 1 alpha	Homo sapiens	156-178
31687952-5	2019	Analyzing the contents of IL-1beta in serum of children with nephrotic syndrome, we found that IL-1beta was significantly increased in children with steroid-resistant nephrotic syndrome and with progression of glomerulonephritis compared with remission and with healthy children (p<0.05).	Steroids	149-156	interleukin 1 alpha	Homo sapiens	95-103
31957703-8	2019	Dex reduced TNF-alpha, IL-6, IL-1beta, ROS, and MDA production, whereas it increased that of SOD and GSH-Px in OGD/R-treated WRL-68 cells.	Dexmedetomidine	0-3	interleukin 1 alpha	Homo sapiens	29-37
31957703-10	2019	Knockdown of Nrf2 reversed the Dex effects on cell proliferation, apoptosis, and expression of TNF-alpha, IL-6, IL-1beta, ROS, MDA, SOD, and GSH-Px.	Dexmedetomidine	31-34	interleukin 1 alpha	Homo sapiens	112-120
31221438-5	2019	RESULTS: Dexamethasone induced a semi-mature phenotype on TRIMEL/DC with low maturation surface marker expressions, decreased pro-inflammatory cytokine induction (IL-1beta and IL-12) and increased release of regulatory cytokines (IL-10 and TGF-beta).	Dexamethasone	9-22	interleukin 1 alpha	Homo sapiens	163-171
31176046-6	2019	However, pharmacological activation of autophagy by Rapamycin (RAPA) efficiently suppressed Abeta-, lipopolysaccharides (LPS)-induced IL-1beta expression via regulating NLRP3-Caspase-1 inflammasome in astrocytes.	Sirolimus	52-61	interleukin 1 alpha	Homo sapiens	134-142
31176046-6	2019	However, pharmacological activation of autophagy by Rapamycin (RAPA) efficiently suppressed Abeta-, lipopolysaccharides (LPS)-induced IL-1beta expression via regulating NLRP3-Caspase-1 inflammasome in astrocytes.	Sirolimus	63-67	interleukin 1 alpha	Homo sapiens	134-142
31176046-8	2019	Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing.	3-methyladenine	20-24	interleukin 1 alpha	Homo sapiens	98-106
31176046-8	2019	Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing.	Progesterone	59-61	interleukin 1 alpha	Homo sapiens	98-106
31272064-6	2019	Together, our data suggested that AI-2 induced macrophage M1 polarization by activating the TNFSF9/IL-1beta pathway.	N-octanoylhomoserine lactone	34-38	interleukin 1 alpha	Homo sapiens	99-107
31002427-11	2019	Likewise, serum TGF-beta1 and IL-1beta levels were significantly elevated in patients with CKD, with increase in plasma and urinary TMAO levels and altered redox status throughout different CKD stages.	trimethyloxamine	132-136	interleukin 1 alpha	Homo sapiens	30-38
31383341-3	2019	Interleukin-1 (IL-1) blockers could be used in colchicine resistant cases.	Colchicine	47-57	interleukin 1 alpha	Homo sapiens	0-13
31229280-10	2019	Co-incubation of high-glucose-treated endothelial cells with milk extracts from group S15 improved cell viability compared with cells treated with high glucose only; it also reduced intracellular lipid peroxidation (144.3 +- 0.4 vs. 177.5 +- 1.9%), reactive oxygen species (141.3 +- 0.9 vs. 189.3 +- 4.7 optical density units), and cytokine release (tumor necrosis factor-alpha, IL-1beta, IL-6).	Glucose	22-29	interleukin 1 alpha	Homo sapiens	379-387
31383341-3	2019	Interleukin-1 (IL-1) blockers could be used in colchicine resistant cases.	Colchicine	47-57	interleukin 1 alpha	Homo sapiens	15-19
31383341-4	2019	However, starting IL-1 blocker treatment after colchicine failure may lose opportunity for effective treatment.	Colchicine	47-57	interleukin 1 alpha	Homo sapiens	18-22
31242957-8	2019	MiR-106-5p mimic downregulated MAP3K14 mRNA and protein expression levels, inhibited p-NF-kappaB levels and decreased IL-1 and TNF-alpha secretion, whereas miR-106-5p inhibitor had the opposite effect.	mir-106-5p	0-10	interleukin 1 alpha	Homo sapiens	118-122
30805836-12	2019	Dexamethasone treatments resulted in the most profound dysregulation of expression of NO, TNF, IL-1beta, NGF, CD68, and MHCII as well as ramified morphology and uptake of myelin.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	95-103
31242957-9	2019	Bay11-7085 inhibited p-NF-kappaB expression and TNF-alpha and IL-1 secretion.	BAY 11-7085	0-10	interleukin 1 alpha	Homo sapiens	62-66
31450835-7	2019	In a model of gout, treatment with Y-27632 reduced neutrophil accumulation, IL-1beta levels and hypernociception in the joint.	Y 27632	35-42	interleukin 1 alpha	Homo sapiens	76-84
31480216-5	2019	Docosahexaenoic acid upregulated filaggrin and loricrin expression at mRNA levels in addition to suppressing overexpression of tumor necrosis factor-alpha (TNF-alpha), interleukin-alpha (IL-1alpha), and interleukin-6 (IL-6) stimulated by polyinosinic-polycytidylic acid (poly I:C) plus lipopolysaccharide (LPS) (stimulation cocktail) in cultured NHEK cells.	Docosahexaenoic Acids	0-20	interleukin 1 alpha	Homo sapiens	187-196
31105125-8	2019	Together, our results revealed that COX-2/PGE2 signaling was involved in the regulation of IL-1beta autostimulation, thus forming an IL-1beta/COX-2/PGE2 pathway loop, which may result in the high inflammation level in human T2DM islets and the inflammatory impairment of beta cells.	Dinoprostone	42-46	interleukin 1 alpha	Homo sapiens	91-99
31105125-8	2019	Together, our results revealed that COX-2/PGE2 signaling was involved in the regulation of IL-1beta autostimulation, thus forming an IL-1beta/COX-2/PGE2 pathway loop, which may result in the high inflammation level in human T2DM islets and the inflammatory impairment of beta cells.	Dinoprostone	42-46	interleukin 1 alpha	Homo sapiens	133-141
31105125-8	2019	Together, our results revealed that COX-2/PGE2 signaling was involved in the regulation of IL-1beta autostimulation, thus forming an IL-1beta/COX-2/PGE2 pathway loop, which may result in the high inflammation level in human T2DM islets and the inflammatory impairment of beta cells.	Dinoprostone	148-152	interleukin 1 alpha	Homo sapiens	91-99
31105125-8	2019	Together, our results revealed that COX-2/PGE2 signaling was involved in the regulation of IL-1beta autostimulation, thus forming an IL-1beta/COX-2/PGE2 pathway loop, which may result in the high inflammation level in human T2DM islets and the inflammatory impairment of beta cells.	Dinoprostone	148-152	interleukin 1 alpha	Homo sapiens	133-141
31105125-9	2019	Breaking this IL-1beta/COX-2/PGE2 pathway loop provides a potential therapeutic strategy to improve beta cell function in the treatment of T2DM patients.	Dinoprostone	29-33	interleukin 1 alpha	Homo sapiens	14-22
31434807-7	2019	We found that retinoic acid-related orphan receptor alpha (RORalpha) was increased by inflammatory mediators, such as IL-1beta, and bound to ANGPTL4 promoter in MSCs.	Tretinoin	14-27	interleukin 1 alpha	Homo sapiens	118-126
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	interleukin 1 alpha	Homo sapiens	80-88
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	interleukin 1 alpha	Homo sapiens	83-91
31302140-7	2019	Notably, dulaglutide treatment suppressed high glucose- induced maturation of IL-1beta and IL-18.	Glucose	47-54	interleukin 1 alpha	Homo sapiens	78-86
31352795-7	2019	Donor simvastatin treatment did not affect donor lipid levels but was associated with a specific transplant myocardial biopsy gene expression profile, and a decrease in recipient postoperative plasma levels of CXCL10 (C-X-C motif chemokine 10), interleukin-1alpha, placental growth factor, and platelet-derived growth factor-BB.	Simvastatin	6-17	interleukin 1 alpha	Homo sapiens	245-263
31434236-9	2019	In the presence of IL-1beta, these donors showed a significant increase in cartilage matrix gene expression and GAG content relative to hyperoxic conditions.	Glycosaminoglycans	112-115	interleukin 1 alpha	Homo sapiens	19-27
31412804-0	2019	Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.	Uric Acid	0-9	interleukin 1 alpha	Homo sapiens	26-34
31531346-8	2019	Hepatic damage associated with increased ROS and protein expression levels of NOX4, NLRP3, caspase-1, and IL-1beta was attenuated by AVE 0991, an analogue of Ang-(1-7).	AVE 0991	133-141	interleukin 1 alpha	Homo sapiens	106-114
31412804-0	2019	Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.	ros	128-131	interleukin 1 alpha	Homo sapiens	26-34
31412804-9	2019	RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor.	Uric Acid	119-121	interleukin 1 alpha	Homo sapiens	27-35
31412804-11	2019	In vivo results showed that UA caused the vascular endothelial injury by activating NLRP3/IL-1beta pathway.	Uric Acid	28-30	interleukin 1 alpha	Homo sapiens	90-98
31412804-13	2019	CONCLUSIONS: UA could regulate NLRP3/IL-1beta signaling pathway through ROS activation and K+ efflux and further induce vascular endothelial cells injury in early stages of CKD.	ros	72-75	interleukin 1 alpha	Homo sapiens	37-45
31485193-7	2019	In addition, levels of ROS, caspase1, and IL-1beta increased in a time- and dose-dependent manner in the high glucose group, even with an increased expression of LC3 (p < 0.01).	Glucose	110-117	interleukin 1 alpha	Homo sapiens	42-50
31412063-7	2019	Treatment of HSVEC with exogenous ATP led to interleukin 1beta (IL-1beta) release and increased vascular cell adhesion molecule (VCAM) expression.	Adenosine Triphosphate	34-37	interleukin 1 alpha	Homo sapiens	64-72
30919933-7	2019	High levels of D-fructose compared to D-glucose led to activation of DCs in vitro by promoting interleukin (IL)-6 and IL-1beta production.	Fructose	15-25	interleukin 1 alpha	Homo sapiens	118-126
31496653-10	2019	After 1 year of treatment with acarbose or metformin, IL-6, TNF-alpha, IL-1beta and ferritin levels were significantly decreased compared with the baseline.	Acarbose	31-39	interleukin 1 alpha	Homo sapiens	71-79
31011875-6	2019	Histological and biochemical analyses showed that the VOB-treated wounds exhibited a significant increase of granular tissue and controlled inflammatory response by modulation of the release of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1.	vob	54-57	interleukin 1 alpha	Homo sapiens	241-245
30919933-7	2019	High levels of D-fructose compared to D-glucose led to activation of DCs in vitro by promoting interleukin (IL)-6 and IL-1beta production.	Glucose	40-47	interleukin 1 alpha	Homo sapiens	118-126
31100399-1	2019	This study evaluated the solubility of low-processed wood fibers produced from a low temperature acid hydrotropic fractionation (AHF) in an ionic liquid (IL) 1,5-diazabicyclo[4.3.0]non-5-enium acetate (DBNH[OAc].	5-enium acetate	185-200	interleukin 1 alpha	Homo sapiens	140-159
31071396-6	2019	In addition, the levels of NO, iNOS, TNF-alpha, IFN-gamma, IL-1beta and IL-12 were enhanced in the peritoneal macrophages by stimulation with cationic polymer modified AHPP nanoparticles.	Polymers	151-158	interleukin 1 alpha	Homo sapiens	59-67
31071396-6	2019	In addition, the levels of NO, iNOS, TNF-alpha, IFN-gamma, IL-1beta and IL-12 were enhanced in the peritoneal macrophages by stimulation with cationic polymer modified AHPP nanoparticles.	ahpp	168-172	interleukin 1 alpha	Homo sapiens	59-67
30515817-6	2019	MC1568 alleviated IL-1beta activation of SMSCs, whereas CI994 and FK228 produced a minimal or opposite effect in vitro.	MC1568	0-6	interleukin 1 alpha	Homo sapiens	18-26
30414245-13	2019	AE2 suppressed gene expression level of IL-1alpha, SRD5A1, TNFalpha (0.3815, P = 0.0254; 0.3418, P = 0.0271; 0.1997, P = 0.0623).	Etiocholanolone	0-3	interleukin 1 alpha	Homo sapiens	40-49
30733317-2	2019	P2X7 receptor activation leads to the release of the proinflammatory cytokine IL-1beta in the brain, and antagonism of the P2X7 receptor is a novel therapeutic strategy to dampen adenosine triphosphate-dependent IL-1beta signaling.	Adenosine	179-188	interleukin 1 alpha	Homo sapiens	78-86
31268709-10	2019	The ability of prenylated stilbenoids to attenuate the production of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was further evaluated using LPS-stimulated THP-1 macrophages.	Stilbenes	26-37	interleukin 1 alpha	Homo sapiens	159-167
31311846-3	2019	Here, we demonstrated that the carbohydrate-binding protein galectin-3 stimulated microenvironment remodeling in the cornea by promoting the paracrine action of secreted interleukin-1beta (IL-1beta).	Carbohydrates	31-43	interleukin 1 alpha	Homo sapiens	189-197
31277614-7	2019	The potential for succinic acid to have anti-inflammatory effects was assessed by measuring the release of inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNFalpha, and the inflammatory messenger PGE2, from THP-1 human macrophages after treatment with succinic acid and LPS.	Succinic Acid	18-31	interleukin 1 alpha	Homo sapiens	130-139
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 1 alpha	Homo sapiens	173-181
30653843-1	2019	OBJECTIVE: To assess the efficacy and safety of the anti-interleukin-1alpha/beta (anti-IL-1alpha/beta) dual variable domain immunoglobulin lutikizumab (ABT-981) in patients with knee osteoarthritis (OA) and evidence of synovitis.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	152-155	interleukin 1 alpha	Homo sapiens	57-75
31315072-7	2019	Suhuang also inhibited NLRP3 inflammasome activation, as evidenced by disrupting the assembly of NLRP3 inflammasome and reducing the expression of cleaved caspase-1, and decreased IL-1beta secretion.	suhuang	0-7	interleukin 1 alpha	Homo sapiens	180-188
31374866-8	2019	CONCLUSIONS: These results suggest that treatment with EEP in chondrocytes that were stimulated with IL-1beta has beneficial effects, such as a decrease in the expression of proteins associated with autophagy, MMP13, and production of nitric oxide, and also increased collagen II.	Nitric Oxide	235-247	interleukin 1 alpha	Homo sapiens	101-109
31562717-2	2019	This study was designed to show the development of NAFLD in the young tribal population of Tripura and the link between 25(OH) Vitamin D and pro-inflammatory cytokines (IL-1a, IL-6, IL-17a and TNF-alpha) and -inflammatory cytokines such as IL - 4 and IL - 10 and the development of NAFLD while at the same time throws light on the prevalence of 25(OH) Vitamin D deficiencies and the levels of pro-inflammatory cytokines in the study group.	26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3	120-136	interleukin 1 alpha	Homo sapiens	169-174
31228738-9	2019	However, tylvalosin administration in sows alleviated these signs in their piglets; increased total antioxidant capacity and serum glutathione levels; decreased serum IL-1beta, TNF-alpha, and IL-10 levels; improved the percentages of neutrophils and lymphocytes in the blood; and increased the body weight of the weaning piglets.	tylvalosin	9-19	interleukin 1 alpha	Homo sapiens	167-175
30876886-6	2019	TNF-alpha and IL-1beta aggravated cytotoxicity of TVX more than IL-6.	tvx	50-53	interleukin 1 alpha	Homo sapiens	14-22
31366948-0	2019	Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1beta release.	miltefosine	0-11	interleukin 1 alpha	Homo sapiens	98-106
31366948-7	2019	The Toll like receptor (TLR) signaling pathway was blunted by Miltefosine treatment, resulting in decreased TLR4 recruitment to cell-surface and ~75% reduction in LPS induced pro-IL-1beta mRNA levels.	miltefosine	62-73	interleukin 1 alpha	Homo sapiens	179-187
31366948-10	2019	Collectively, our data shows that Miltefosine induced ABCA1 mediated cholesterol release, induced AMPK phosphorylation and mitophagy, while dampening NLRP3 inflammasome assembly and IL-1beta release.	miltefosine	34-45	interleukin 1 alpha	Homo sapiens	182-190
30180922-0	2019	1,25(OH)2D3 Attenuates IL-1beta-Induced Epithelial-to-Mesenchymal Transition Through Inhibiting the Expression of lncTCF7.	Calcitriol	0-11	interleukin 1 alpha	Homo sapiens	23-31
30180922-9	2019	Based on the above experiments, we found that 1,25(OH)2D3 attenuates IL-1beta-induced increased proliferation and invasion in colorectal cancer through enhancing VDR, which inhibits the expression of lncTCF7 by directly binding to its promoter region.	(oh)2d3	50-57	interleukin 1 alpha	Homo sapiens	69-77
31060888-4	2019	At the molecular level, cirsiliol suppressed the expression of IL-6-induced inflammatory marker genes such as CRP, IL-1beta, ICAM-1 and SOCS3, IL-6-induced activation of Jak2, gp130, STAT3 and ERK and nuclear translocation of STAT3, as measured by PCR, immunofluorescence staining and western blot analysis.	cirsiliol	24-33	interleukin 1 alpha	Homo sapiens	115-123
30862504-3	2019	We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation.	Erythromycin	56-68	interleukin 1 alpha	Homo sapiens	177-185
30862504-3	2019	We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation.	Macrolides	83-92	interleukin 1 alpha	Homo sapiens	177-185
31001893-7	2019	The phosphorylation of p38 MAPK induced by PMs was shown to be critically important for the increases in IL-1alpha and IL-1beta expression.	Promethium	43-46	interleukin 1 alpha	Homo sapiens	105-114
30916999-5	2019	IL-1beta treatment induced profound prostaglandin E2 release in AR compared with AT cells.	Dinoprostone	36-52	interleukin 1 alpha	Homo sapiens	0-8
30916999-6	2019	Incubation of IL-1beta treated AT and AR tendon-derived stromal cells in 15-epi-LXA4 or MaR1 reduced proinflammatory eicosanoids and potentiated the release of proresolving mediators.	Eicosanoids	117-128	interleukin 1 alpha	Homo sapiens	14-22
31001893-7	2019	The phosphorylation of p38 MAPK induced by PMs was shown to be critically important for the increases in IL-1alpha and IL-1beta expression.	Promethium	43-46	interleukin 1 alpha	Homo sapiens	119-127
30937478-5	2019	Other medications like azathioprine, methotrexate or interleukin-1 or -6 blockers can be used when standard steroid treatment is not adequate.	Steroids	108-115	interleukin 1 alpha	Homo sapiens	53-72
31004811-5	2019	The resulting PGZ-NE showed good anti-inflammatory efficacy by decreasing the expression of inflammatory cytokines IL-6, IL-1beta and TNF-alpha.	pgz-ne	14-20	interleukin 1 alpha	Homo sapiens	121-129
31091351-6	2019	Moreover, heme itself stimulated significant Mphi pro-IL-1beta gene and protein expression via an S100A8-mediated mechanism and greatly amplified S100A8-driven NLRP3 inflammasome-mediated IL-1beta secretion.	Heme	10-14	interleukin 1 alpha	Homo sapiens	54-62
31115540-5	2019	Increased levels of proinflammatory cytokines TNF-alpha, COX-2, IL-6 and IL-1beta following UVB exposure were suppressed by the introduction of DCEQA.	dceqa	144-149	interleukin 1 alpha	Homo sapiens	73-81
31212975-0	2019	Quercetin Inhibits the Production of IL-1beta-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-kappaB Signaling Pathways.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	37-45
31212975-3	2019	The present study explored whether quercetin can inhibit the interleukin-1beta (IL-1beta)-induced production of inflammatory cytokines and chemokines in ARPE-19 cells.	Quercetin	35-44	interleukin 1 alpha	Homo sapiens	80-88
30865473-6	2019	Moreover, palmitate induced gene expression (monocyte chemoattractant protein 1, matrix metalloproteinase-2, IL-1beta, IL-6, IL-8, and TNF-alpha) and intracellular protein content (plasminogen activator inhibitor-1 and urokinase plasminogen activator) of inflammatory mediators.	Palmitates	10-19	interleukin 1 alpha	Homo sapiens	109-117
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	interleukin 1 alpha	Homo sapiens	153-175
31042669-0	2019	Effects of interleukin-1 antagonism on cortisol levels in individuals with obesity: a randomized clinical trial.	Hydrocortisone	39-47	interleukin 1 alpha	Homo sapiens	11-24
31298400-8	2019	RESULTS: 5/10 mg/L Berberine intervention could noticeably decrease both TGF-beta1 and IL-1beta levels, 25/50/100 micromol/L Hesperidin could reduce IL-1beta secretion from TGF-beta1 stimulated cardiac fibroblasts.	Hesperidin	125-135	interleukin 1 alpha	Homo sapiens	149-157
30466341-4	2019	Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-alpha, IL-1beta, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939.	XAV939	175-181	interleukin 1 alpha	Homo sapiens	82-90
31108461-0	2019	IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels.	Oxygen	96-102	interleukin 1 alpha	Homo sapiens	0-9
31205858-12	2019	Propofol also attenuated the LPS-induced mRNA expression of IL-1beta and TNF-alpha.	Propofol	0-8	interleukin 1 alpha	Homo sapiens	60-68
31120863-7	2019	We found that DKO HSCs and progenitors have impaired sensing of inflammatory signals ex vivo, and that levels of IL1-beta and MIG are higher in the bone marrow after LPS than after 5-FU administration.	Fluorouracil	181-185	interleukin 1 alpha	Homo sapiens	113-121
31118410-5	2019	We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA alpha1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1beta (IL-1beta) in PTECs.	acadesine	66-120	interleukin 1 alpha	Homo sapiens	455-463
30653843-1	2019	OBJECTIVE: To assess the efficacy and safety of the anti-interleukin-1alpha/beta (anti-IL-1alpha/beta) dual variable domain immunoglobulin lutikizumab (ABT-981) in patients with knee osteoarthritis (OA) and evidence of synovitis.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	152-155	interleukin 1 alpha	Homo sapiens	87-96
31217433-12	2019	Together, these data provide new insights on the regulation of IL-1beta secretion by DHA and on its potential benefit in 5-FU-based chemotherapy.	Docosahexaenoic Acids	85-88	interleukin 1 alpha	Homo sapiens	63-71
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	interleukin 1 alpha	Homo sapiens	94-102
29941233-11	2019	CONCLUSIONS: In very premature infants, early administration of fish oil containing LE significantly decreased IL-1beta and IL-6 levels in serum and BALF and was associated with shorter duration of ventilator support and less bronchopulmonary dysplasia (BPD).	Fish Oils	64-72	interleukin 1 alpha	Homo sapiens	111-119
31298400-8	2019	RESULTS: 5/10 mg/L Berberine intervention could noticeably decrease both TGF-beta1 and IL-1beta levels, 25/50/100 micromol/L Hesperidin could reduce IL-1beta secretion from TGF-beta1 stimulated cardiac fibroblasts.	Berberine	19-28	interleukin 1 alpha	Homo sapiens	87-95
30488141-4	2019	Treatment with RSG ameliorated axonal injury, cell apoptosis, glia activation, and the release of inflammatory factors such as TNF-alpha, IL-1beta, and IL-6.	Rosiglitazone	15-18	interleukin 1 alpha	Homo sapiens	138-146
31028903-5	2019	Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11.	Fatty Acids	56-67	interleukin 1 alpha	Homo sapiens	409-413
31185840-5	2019	Therefore, antagonists against interleukin 1 or IL-1 receptors can be used for treatment if colchicine, steroids or nonsteroidal anti-inflammatory drugs are ineffective or contraindicated.	Colchicine	92-102	interleukin 1 alpha	Homo sapiens	31-44
31185840-5	2019	Therefore, antagonists against interleukin 1 or IL-1 receptors can be used for treatment if colchicine, steroids or nonsteroidal anti-inflammatory drugs are ineffective or contraindicated.	Steroids	104-112	interleukin 1 alpha	Homo sapiens	31-44
30284175-8	2019	Additionally, correlations were identified between 8-isoprostane and proinflammatory factors (IL-1beta, IL-18, and TNF-alpha).	8-epi-prostaglandin F2alpha	51-64	interleukin 1 alpha	Homo sapiens	94-102
31138166-9	2019	Importantly, activation of alpha7nAChR with its agonist PNU-282987 inhibited NF-kappaB, decreased TNF-alpha, IL-1beta, and IL-6 release, and increased IL-10 release in monocytes from the PE women (all p < 0.01).	PNU-282987	56-66	interleukin 1 alpha	Homo sapiens	109-117
31231362-9	2019	C-SVMP was able to induce increased production of the cytokines IL-1beta and IL-6 and the chemokines CXCL8/IL-8, CCL2/MCP-1, and CXCL9/MIG in the human whole blood model.	c-svmp	0-6	interleukin 1 alpha	Homo sapiens	64-72
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 1 alpha	Homo sapiens	79-88
31100089-9	2019	catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.	Catechin	0-8	interleukin 1 alpha	Homo sapiens	90-98
31053727-6	2019	Moreover, transfection with miR-125b mimic caused marked inhibition of IL-1beta-induced phosphorylation of p38-MAPK, JNK-MAPKs and ERK-MAPKs and also suppressed the nuclear levels of NF-kappaBp50, NF-kappaBp65 and inhibited the activation of IkappaBalpha.	mir-125b	28-36	interleukin 1 alpha	Homo sapiens	71-79
30952515-4	2019	IRF3 activation by IL-1beta is dependent upon the DNA-sensing pathway adaptor, stimulator of interferon genes (STING), through the recognition of cytosolic mtDNA by cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS).	Cyclic GMP	165-195	interleukin 1 alpha	Homo sapiens	19-27
30952515-4	2019	IRF3 activation by IL-1beta is dependent upon the DNA-sensing pathway adaptor, stimulator of interferon genes (STING), through the recognition of cytosolic mtDNA by cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS).	Guanosine Monophosphate	197-200	interleukin 1 alpha	Homo sapiens	19-27
31205941-10	2019	Pretreatment with TCA decreased the degradation of IkappaBalpha and increased the expression of p-IkappaBalpha, indicating that NF-kappaB inactivation was induced by TCA in IL-1beta-stimulated SW1353 cells.	cinnamaldehyde	18-21	interleukin 1 alpha	Homo sapiens	173-181
31205941-10	2019	Pretreatment with TCA decreased the degradation of IkappaBalpha and increased the expression of p-IkappaBalpha, indicating that NF-kappaB inactivation was induced by TCA in IL-1beta-stimulated SW1353 cells.	cinnamaldehyde	166-169	interleukin 1 alpha	Homo sapiens	173-181
31053727-7	2019	Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1beta also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-gamma, TGF-beta1, IGFBP-1 and PGDF-BB.	mir-125b	43-51	interleukin 1 alpha	Homo sapiens	77-85
30851246-3	2019	When tested in vitro on human dendritic cells (DCs), CHF6001 decreased the release of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (CXCL8, CCL3, CXCL10 and CCL19) and of Th1- and Th17-polarizing cytokines (IL-12, IL-23 and IL-1beta).	3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide	53-60	interleukin 1 alpha	Homo sapiens	238-246
30303592-10	2019	We found that NF-kappaB signaling was activated only upon stimulation with 100 microM H2 O2 leading to upregulation of TLR4 signaling and IL-1beta.	Hydrogen Peroxide	86-91	interleukin 1 alpha	Homo sapiens	138-146
30803848-6	2019	SLE patients exhibit increased levels of ATP which binds to P2X receptors resulting in activation of the inflammasome and consequent release of IL-1beta and IL-18, cytokines associated with disease pathogenesis.	Adenosine Triphosphate	41-44	interleukin 1 alpha	Homo sapiens	144-152
30303592-9	2019	In vitro, 100 microM, but not 50 microM, of H2 O2 increased expression of TLR4, IL-1beta and COX-2.	Hydrogen Peroxide	44-49	interleukin 1 alpha	Homo sapiens	80-88
30620245-6	2019	Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1beta (p = 0.037).	Fatty Acids, Unsaturated	7-33	interleukin 1 alpha	Homo sapiens	210-218
30620245-6	2019	Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1beta (p = 0.037).	Fatty Acids, Unsaturated	35-39	interleukin 1 alpha	Homo sapiens	210-218
31178664-5	2019	The results demonstrate that compared with the low-glucose culture, high glucose triggered higher cell death and increased IL-18 and IL-1beta mRNA expression and protein production.	Glucose	73-80	interleukin 1 alpha	Homo sapiens	133-141
30811636-8	2019	Lactate mediated part of the crosstalk between tumor cells and Mphis, promoting secretion of IL-1beta, IL-10, IL-6, and up-regulation of hypoxia induced factor-1alpha expression, and down-regulation of p65-NFkappaB phosphorylation in Mphis.	Lactic Acid	0-7	interleukin 1 alpha	Homo sapiens	93-101
31052183-4	2019	The concentration-related effects of RSV on IL-1 alpha and NO levels were assessed using the respective ELISA kits.	Resveratrol	37-40	interleukin 1 alpha	Homo sapiens	44-54
31052183-8	2019	Significant increases in IL-1alpha levels were observed with lower concentrations of RSV.	Resveratrol	85-88	interleukin 1 alpha	Homo sapiens	25-34
31052183-9	2019	However, at higher RSV concentrations (10-100 muM), IL-1 levels decreased.	Resveratrol	19-22	interleukin 1 alpha	Homo sapiens	52-56
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	Acetylcysteine	9-12	interleukin 1 alpha	Homo sapiens	96-104
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	ros	16-19	interleukin 1 alpha	Homo sapiens	96-104
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	Glucose	52-59	interleukin 1 alpha	Homo sapiens	96-104
31178664-9	2019	Intrudingly, H2S could ameliorate high glucose-induced ROS formation, IL-18 and IL-1beta expression, and inflammasome activation.	Deuterium	13-16	interleukin 1 alpha	Homo sapiens	80-88
31178664-9	2019	Intrudingly, H2S could ameliorate high glucose-induced ROS formation, IL-18 and IL-1beta expression, and inflammasome activation.	Glucose	39-46	interleukin 1 alpha	Homo sapiens	80-88
31010106-8	2019	After exposure to W-PM2.5, the levels of interleukins (IL)-1beta and IL-12 p70 significantly increased.	w-pm2	18-23	interleukin 1 alpha	Homo sapiens	41-64
30833078-4	2019	RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA.	Uric Acid	39-42	interleukin 1 alpha	Homo sapiens	83-91
30964128-7	2019	The important anti-inflammatory action of BC-PAMAM was clearly documented by decreased production of total IL-1alpha, assayed with an ELISA test with unstimulated and stimulated by bacterial antigens (LPS and GroEL) HaCaT cells.	bc-pamam	42-50	interleukin 1 alpha	Homo sapiens	107-116
30944389-6	2019	A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1beta precursor by reducing reactive oxygen species generation and NF-kappaB activation in lipopolysaccharide-activated macrophages.	Glucosamine	34-38	interleukin 1 alpha	Homo sapiens	77-85
30970613-3	2019	PL exerted a protective effect on HUVEC in an inflammatory milieu by inhibiting IL-1alpha-activated NF-kappaB pathway and by inducing the secretion of PGE2, a pro-resolving molecule in the wound microenvironment.	pl	0-2	interleukin 1 alpha	Homo sapiens	80-89
30963625-9	2019	Lidocaine dramatically reduced the protein expression of IL-1alpha, IL-6, THF-alpha, ELAVL1, NLRP3, caspase-1, and IL-1beta in adenovirus-infected thyroid follicular epithelial cells.	Lidocaine	0-9	interleukin 1 alpha	Homo sapiens	57-66
30944389-6	2019	A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1beta precursor by reducing reactive oxygen species generation and NF-kappaB activation in lipopolysaccharide-activated macrophages.	oxygen species	117-131	interleukin 1 alpha	Homo sapiens	77-85
30696657-4	2019	Pomalidomide-induced absence of alternatively activated macrophages led to a decrease in fibrosis at PanIN lesions and in syngeneic tumors; this was due to generation of an inflammatory, immune-responsive environment with increased expression of IL1alpha and presence of activated (IFNgamma-positive) CD4+ and CD8+ T-cell populations.	pomalidomide	0-12	interleukin 1 alpha	Homo sapiens	246-254
30929860-10	2019	Rintatolimod was predicted to make available substantial remission in a significant subset of subjects, in particular those with low levels of IL-1alpha, IL-17, and cortisol; intermediate levels of progesterone and FSH; and high estrogen levels.	poly(I).poly(c12,U)	0-12	interleukin 1 alpha	Homo sapiens	143-152
31365342-5	2019	In colchicine-resistant or intolerant patients, recent insights into the pathogenesis of FMF have made the anti-IL1 treatments important.	Colchicine	3-13	interleukin 1 alpha	Homo sapiens	112-115
30724633-0	2019	Silica nanoparticles as an enhancer in the IL-1beta-induced inflammation cycle of A549 cells.	Silicon Dioxide	0-6	interleukin 1 alpha	Homo sapiens	43-51
30724633-3	2019	However, whether nano-SiO2 can increase the IL-1beta-induced inflammatory expression in A549 cells has not been tested.	Silicon Dioxide	22-26	interleukin 1 alpha	Homo sapiens	44-52
30724633-9	2019	The synergistic effect of nano-SiO2 and IL-1beta was observed on the new production of IL-1beta and IL-6 in A549 cells.	Silicon Dioxide	31-35	interleukin 1 alpha	Homo sapiens	87-95
29675712-5	2019	RESULTS AND DISCUSSION: Terpenes reduced the pro-inflammatory cytokines TNF-alpha and IL-1alpha and increased the production of IL-10.	Terpenes	24-32	interleukin 1 alpha	Homo sapiens	86-95
30729671-7	2019	Exogenous Pros1 inhibited p.g-LPS-induced production of TNF-alpha, IL-6, IL-1beta, MMP9/2 and RANKL in a Tyro3-dependent manner as revealed by PCR, Western blot analysis, ELISA and gelatin zymography.	p.g-lps	26-33	interleukin 1 alpha	Homo sapiens	73-81
30776150-7	2019	Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response.	Leucine	27-34	interleukin 1 alpha	Homo sapiens	125-133
30776150-7	2019	Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response.	Leucine	27-34	interleukin 1 alpha	Homo sapiens	337-345
30918241-16	2019	CONCLUSIONS Sufentanil stimulation triggers downregulation of inflammatory factors such as HIF-1alpha, TNF-alpha, IL-1ss, and IL-6, possibly through suppressing the p38/ERK/JNK/NF-kappaB-p65/COX2 pathways, and thereby reduces the damage to IR hepatic cells.	Sufentanil	12-22	interleukin 1 alpha	Homo sapiens	114-118
30803233-2	2019	Herein, we perform in situ measurements of water interacting with the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate, [C4mim][Ace], using ambient pressure X-ray photoelectron spectroscopy in order to assess the interfacial uptake of water quantitatively as a function of temperature, pressure, and water mole fraction ( xw).	Water	43-48	interleukin 1 alpha	Homo sapiens	70-89
30803233-2	2019	Herein, we perform in situ measurements of water interacting with the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate, [C4mim][Ace], using ambient pressure X-ray photoelectron spectroscopy in order to assess the interfacial uptake of water quantitatively as a function of temperature, pressure, and water mole fraction ( xw).	butyl-3-methylimidazolium acetate	90-123	interleukin 1 alpha	Homo sapiens	70-89
30803233-2	2019	Herein, we perform in situ measurements of water interacting with the ionic liquid (IL) 1-butyl-3-methylimidazolium acetate, [C4mim][Ace], using ambient pressure X-ray photoelectron spectroscopy in order to assess the interfacial uptake of water quantitatively as a function of temperature, pressure, and water mole fraction ( xw).	Water	240-245	interleukin 1 alpha	Homo sapiens	70-89
30930781-5	2019	The stimulation of PBMCs with an AIM2 inflammasome activator, Poly dA:dT, led to IL-1alpha, but not IL-1beta, release.	poly(dA)	62-69	interleukin 1 alpha	Homo sapiens	81-90
30930781-5	2019	The stimulation of PBMCs with an AIM2 inflammasome activator, Poly dA:dT, led to IL-1alpha, but not IL-1beta, release.	Thymidine	70-72	interleukin 1 alpha	Homo sapiens	81-90
30867043-7	2019	Treatment with IL-1beta induced release of the prostacyclin metabolite 6-keto PGF1alpha in tendon cells isolated from diseased supraspinatus and Achilles tendons but not in cells from healthy comparator tendons.	Epoprostenol	47-59	interleukin 1 alpha	Homo sapiens	15-23
30867043-9	2019	Incubation of IL-1beta treated diseased tendon cells with selective mPGES-1 inhibitor Compound III, reduced PGE2, and simultaneously increased 6-keto PGF1alpha production.	Dinoprostone	108-112	interleukin 1 alpha	Homo sapiens	14-22
30867043-9	2019	Incubation of IL-1beta treated diseased tendon cells with selective mPGES-1 inhibitor Compound III, reduced PGE2, and simultaneously increased 6-keto PGF1alpha production.	6-Ketoprostaglandin F1 alpha	143-159	interleukin 1 alpha	Homo sapiens	14-22
30871515-11	2019	Yokuininto significantly inhibited the lipopolysaccharide (LPS)-induced secretion of IL-1alpha by approximately 63.2% compared to the LPS-treated macrophages.	yokuininto	0-10	interleukin 1 alpha	Homo sapiens	85-94
30956980-4	2019	RT-qPCR data confirmed the accuracy of microarray data, and cytokines assay results indicated that 6 of the total 27 inflammatory cytokine secretions were significantly inhibited by myricetin pretreatment, including TNF-alpha, IFN-gamma, IL-1alpha, IL-1beta, IL-2, and IL-6.	myricetin	182-191	interleukin 1 alpha	Homo sapiens	238-247
30841550-5	2019	Notably, anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity.	Curcumin	57-65	interleukin 1 alpha	Homo sapiens	141-160
30641295-8	2019	RESULTS: Of all analyzed proteins, only the levels of IL-1alpha, Il-1beta and TNFalpha in GCF from the injured teeth with resorption were higher than in GCF from control teeth on the visit during which the EIRR was diagnosed.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	90-93	interleukin 1 alpha	Homo sapiens	54-63
30641295-9	2019	In univariate logistic regression model, the concentration of IL-1alpha in GCF was found as the strongest risk factor for the occurrence of EIRR.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	75-78	interleukin 1 alpha	Homo sapiens	62-71
30964194-10	2019	The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFalpha, IL1, IL6, IL8), c) DNA damage induced by MGO or IR.	glucuronyl glucosamine glycan sulfate	30-33	interleukin 1 alpha	Homo sapiens	152-155
30591403-6	2019	Cigarette smoke chemical components, such as benzo[alpha]pyrene, known as aryl hydrocarbon receptor (AhR) ligands, themselves activated NF-kappaB and induced proinflammatory cytokines, IL-1beta and IL-6.	Benzo[alpha]pyrene	45-63	interleukin 1 alpha	Homo sapiens	185-193
30637441-6	2019	Metabolic labeling and pull-down assays to investigate de novo protein synthesis clearly demonstrated that intracellular pro-IL-1beta synthesis is rapidly repressed in monocytes after resveratrol treatment due to decreased phosphorylation of Syk and p38.	Resveratrol	184-195	interleukin 1 alpha	Homo sapiens	125-133
31118410-5	2019	We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA alpha1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1beta (IL-1beta) in PTECs.	acadesine	122-127	interleukin 1 alpha	Homo sapiens	455-463
30972073-6	2019	Asparacosin A also inhibited the human recombinant COX-2 enzyme and caused a dose-dependent decrease in the levels of TNF-alpha, IL-1beta, and PGE2 in the carrageenan-induced paws.	asparacosin A	0-13	interleukin 1 alpha	Homo sapiens	129-137
30972073-6	2019	Asparacosin A also inhibited the human recombinant COX-2 enzyme and caused a dose-dependent decrease in the levels of TNF-alpha, IL-1beta, and PGE2 in the carrageenan-induced paws.	Carrageenan	155-166	interleukin 1 alpha	Homo sapiens	129-137
30870525-8	2019	The cocaine group showed lower TNF-alpha (p<0.05) and CCL11 (p<0.05), and higher IL-1beta (p<0.01) concentrations than the control group.	Cocaine	4-11	interleukin 1 alpha	Homo sapiens	81-89
30870525-9	2019	In contrast, the alcohol group showed higher IL-1beta (p<0.01) and lower CXCL12 (p<0.01) concentrations than the control group.	Alcohols	17-24	interleukin 1 alpha	Homo sapiens	45-53
30378164-12	2019	In HCT 116 cells stimulated with TNF-alpha, TUDCA significantly inhibited IL-8 and IL-1alpha expression and suppressed TNF-alpha-induced IkappaBalpha phosphorylation/degradation and DNA-binding activity of NF-kappaB.	ursodoxicoltaurine	44-49	interleukin 1 alpha	Homo sapiens	83-92
30724633-10	2019	The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta.	Silicon Dioxide	42-46	interleukin 1 alpha	Homo sapiens	78-86
30724633-10	2019	The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta.	Silicon Dioxide	42-46	interleukin 1 alpha	Homo sapiens	188-196
30724633-11	2019	IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells.	Silicon Dioxide	39-43	interleukin 1 alpha	Homo sapiens	0-8
30724633-11	2019	IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	128-135	interleukin 1 alpha	Homo sapiens	0-8
30724633-11	2019	IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	128-135	interleukin 1 alpha	Homo sapiens	53-61
30724633-11	2019	IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells.	3-(4-methylphenylsulfonyl)-2-propenenitrile	169-179	interleukin 1 alpha	Homo sapiens	0-8
30724633-11	2019	IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells.	3-(4-methylphenylsulfonyl)-2-propenenitrile	169-179	interleukin 1 alpha	Homo sapiens	53-61
30724633-12	2019	Discussion and conclusion: These results indicated that nano-SiO2 had a toxic effect on A549 cells, and this effect could increase IL-1beta on the A549 cell-induced inflammatory response.	Silicon Dioxide	61-65	interleukin 1 alpha	Homo sapiens	131-139
30691855-10	2019	RESULTS: TPT significantly decreased the expression of TNF-alpha and IL-1beta induced by LPS in THP-1 cells.	Topotecan	9-12	interleukin 1 alpha	Homo sapiens	69-77
30736730-6	2019	In vitro, we found that resiquimod enhances production of nitric oxide (NO) and IL-1beta and not type 1 interferon (IFN) activity in avian macrophages.	resiquimod	24-34	interleukin 1 alpha	Homo sapiens	80-88
29578360-3	2019	Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently.	Colchicine	88-98	interleukin 1 alpha	Homo sapiens	12-30
30611759-9	2019	In addition, western blot and real-time PCR analysis revealed that VPA modulated the protein expression of apoptosis repressor with caspase recruitment domain (ARC), caspase-1 and IL-1beta/IL-18.	Valproic Acid	67-70	interleukin 1 alpha	Homo sapiens	180-188
30867797-0	2019	Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells.	Hymecromone	34-55	interleukin 1 alpha	Homo sapiens	79-92
30794626-5	2019	IL-1beta is produced from HSCs stimulated by lipopolysaccharide (LPS) or palmitic acid which are likely activators of PKR in non-alcoholic steatohepatitis (NASH).	Palmitic Acid	73-86	interleukin 1 alpha	Homo sapiens	0-8
30794626-13	2019	Moreover, palmitic acid also upregulated IL-1beta expression in HSCs, and conditioning medium from palmitic acid-stimulated HSCs promoted HCC proliferation.	Palmitic Acid	10-23	interleukin 1 alpha	Homo sapiens	41-49
30643918-0	2019	Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells.	arsenite	55-63	interleukin 1 alpha	Homo sapiens	142-150
30643918-8	2019	In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD.	arsenite	61-69	interleukin 1 alpha	Homo sapiens	123-131
30643918-10	2019	Activation of LX-2 cells by media from arsenite-treated L-02 cells was inhibited by IL-1beta neutralizing antibody.	arsenite	39-47	interleukin 1 alpha	Homo sapiens	84-92
30643918-11	2019	The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta.	arsenite	15-23	interleukin 1 alpha	Homo sapiens	217-225
30881912-8	2019	Results: T-correlation analysis showed that in both ropivacaine and bupivacaine groups, the TNF-alpha, IL-6, and IL-1 levels decreased after the block.	Ropivacaine	52-63	interleukin 1 alpha	Homo sapiens	113-117
30881912-8	2019	Results: T-correlation analysis showed that in both ropivacaine and bupivacaine groups, the TNF-alpha, IL-6, and IL-1 levels decreased after the block.	Bupivacaine	68-79	interleukin 1 alpha	Homo sapiens	113-117
30728075-7	2019	RESULTS: The HDAC1/2 inhibitor romidepsin was most potent in lowering C16.0+MSU-induced IL-1beta production compared to other specific class I HDAC inhibitors.	msu	76-79	interleukin 1 alpha	Homo sapiens	88-96
30583087-4	2019	In this study we have shown that the increase in exogenous IL-1alpha signaling increases chemosensitivity of both chemosensitive and chemoresistant colorectal cancer cell lines, treated with a widely used cytotoxic antimetabolite 5-fluorouracil (5-FU).	Fluorouracil	230-244	interleukin 1 alpha	Homo sapiens	59-68
30583087-4	2019	In this study we have shown that the increase in exogenous IL-1alpha signaling increases chemosensitivity of both chemosensitive and chemoresistant colorectal cancer cell lines, treated with a widely used cytotoxic antimetabolite 5-fluorouracil (5-FU).	Fluorouracil	246-250	interleukin 1 alpha	Homo sapiens	59-68
30585659-6	2019	We demonstrate that dapsone suppresses production of specific cytokine signatures interleukin (IL)1alpha and IL8 in human epidermal keratinocytes and IL1beta, IL6, IL8 and tumor necrosis factor-alpha in THP-1 cells in response to P. acnes.	Dapsone	20-27	interleukin 1 alpha	Homo sapiens	95-104
31582650-4	2019	2FL reduced PM10-induced excess expression of interleukin (IL)-6, IL-8, IL-1alpha and IL-1beta in HaCaT keratinocytes.	2'-fucosyllactose	0-3	interleukin 1 alpha	Homo sapiens	72-81
30698879-4	2019	The results demonstrate that VC-3LG restores the expression levels of interleukin-1alpha, nerve growth factor and matrix metalloprotease-9 in the dry skin models of reconstructed human epidermal equivalents (RHEEs) and in H2 O2 -treated keratinocytes.	vc-3lg	29-35	interleukin 1 alpha	Homo sapiens	70-88
30240708-4	2019	In addition, IL-1alpha mRNA expression was more strongly induced by BAC and OCT than by the new bis-QACs, at concentrations below the IC50 obtained in normal human epidermal keratinocytes.	bis-qacs	96-104	interleukin 1 alpha	Homo sapiens	13-22
30601517-6	2019	The results showed that GABA supplementation improved the growth performance and modulated the intestinal immunity with inhibiting the gene expressions of IL-22, proinflammatory cytokines (IL-1 and IL-18), and Muc1, but promoted the expressions of anti-inflammatory cytokines (IFN-gamma, IL-4, and IL-10), TLR6 and MyD88.	gamma-Aminobutyric Acid	24-28	interleukin 1 alpha	Homo sapiens	189-193
30522955-5	2019	Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells.	pseudotripeptides	19-36	interleukin 1 alpha	Homo sapiens	82-90
30522955-5	2019	Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells.	Tetradecanoylphorbol Acetate	130-133	interleukin 1 alpha	Homo sapiens	82-90
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Hydrogen	121-129	interleukin 1 alpha	Homo sapiens	201-214
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Water	135-140	interleukin 1 alpha	Homo sapiens	201-214
32254955-8	2019	Under combination therapy, Pd-Cys@MTX@RGD was shown to effectively inhibit the inflammatory response induced by vascular endothelial growth factor (VEGF) and IL-1beta.	pd-cys	27-33	interleukin 1 alpha	Homo sapiens	158-166
32254955-8	2019	Under combination therapy, Pd-Cys@MTX@RGD was shown to effectively inhibit the inflammatory response induced by vascular endothelial growth factor (VEGF) and IL-1beta.	Methotrexate	34-37	interleukin 1 alpha	Homo sapiens	158-166
30246883-7	2019	RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group.	Vitamin D	9-18	interleukin 1 alpha	Homo sapiens	165-173
28847198-7	2019	In addition, results of RT-PCR demonstrated that compared with the placebo, vitamin E intake downregulated gene expression of low-density lipoprotein receptor (LDLR) (p = .008), interleukin-1 (IL-1) (p = .02), and tumor necrosis factor alpha (TNF-alpha) (p = .007) in peripheral blood mononuclear cells of women with implantation failure.	Vitamin E	76-85	interleukin 1 alpha	Homo sapiens	178-198
28847198-8	2019	CONCLUSIONS: Overall, vitamin E supplementation for 12 weeks among women with implantation failure had beneficial effects on endometrial thickness, MDA values, and gene expression of LDLR, IL-1, and TNF-alpha.	Vitamin E	22-31	interleukin 1 alpha	Homo sapiens	189-193
31149893-0	2019	Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1beta pathway activation.	Penequine hydrochloride	0-27	interleukin 1 alpha	Homo sapiens	124-132
30909697-1	2019	IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1&amp;#945;, IL-1&amp;#946;, IL-18, IL-33, IL-36&amp;#945;, IL-36&amp;#946; a IL-37&amp;#947;) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects.	Adenosine Monophosphate	103-106	interleukin 1 alpha	Homo sapiens	0-4
30909697-1	2019	IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1&amp;#945;, IL-1&amp;#946;, IL-18, IL-33, IL-36&amp;#945;, IL-36&amp;#946; a IL-37&amp;#947;) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects.	Adenosine Monophosphate	119-122	interleukin 1 alpha	Homo sapiens	0-4
30909697-1	2019	IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1&amp;#945;, IL-1&amp;#946;, IL-18, IL-33, IL-36&amp;#945;, IL-36&amp;#946; a IL-37&amp;#947;) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects.	Adenosine Monophosphate	119-122	interleukin 1 alpha	Homo sapiens	0-4
30909697-1	2019	IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1&amp;#945;, IL-1&amp;#946;, IL-18, IL-33, IL-36&amp;#945;, IL-36&amp;#946; a IL-37&amp;#947;) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects.	Adenosine Monophosphate	119-122	interleukin 1 alpha	Homo sapiens	0-4
30909697-1	2019	IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1&amp;#945;, IL-1&amp;#946;, IL-18, IL-33, IL-36&amp;#945;, IL-36&amp;#946; a IL-37&amp;#947;) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects.	Adenosine Monophosphate	119-122	interleukin 1 alpha	Homo sapiens	0-4
30622945-10	2018	Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8.	pl	10-12	interleukin 1 alpha	Homo sapiens	99-108
30253244-3	2018	THS exposure generated from as low as the 10 cigarettes-smoking regimen, resulted in increased circulating inflammatory cytokines, tumor necrosis factor alpha, interleukin 1 alpha, and granulocyte macrophage colony-stimulating factor.	THYMIDINE-5'-(DITHIO)PHOSPHATE	0-3	interleukin 1 alpha	Homo sapiens	160-179
30519792-0	2018	Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.	Hydrocarbons, Chlorinated	0-14	interleukin 1 alpha	Homo sapiens	98-111
30519792-1	2018	The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study.	Hydrocarbons, Chlorinated	66-80	interleukin 1 alpha	Homo sapiens	102-106
30546347-9	2018	Conclusion: Overall, our findings demonstrated that infertile women with PCOS, who were candidate for IVF benefited from chromium supplementation for 8 weeks in terms of lowering hs-CRP and improving gene expression of PPAR-gamma, GLUT-1, LDLR, and IL-1, though chromium had no effect on the gene expression of IL-8, TNF-alpha, TGF-beta, and VEGF.	Chromium	121-129	interleukin 1 alpha	Homo sapiens	249-253
30485804-3	2018	Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1beta maturation that requires potassium efflux.	Potassium	143-152	interleukin 1 alpha	Homo sapiens	109-117
30485805-4	2018	Guided by the discovery of the immunomodulatory activity of vioprolides, cyclic peptides isolated from myxobacteria, we observe IL-1beta maturation independent of canonical inflammasome pathways, yet dependent on intrinsic apoptosis.	vioprolides	60-71	interleukin 1 alpha	Homo sapiens	128-136
30485805-4	2018	Guided by the discovery of the immunomodulatory activity of vioprolides, cyclic peptides isolated from myxobacteria, we observe IL-1beta maturation independent of canonical inflammasome pathways, yet dependent on intrinsic apoptosis.	Peptides, Cyclic	73-88	interleukin 1 alpha	Homo sapiens	128-136
30175447-3	2018	The IL-1beta response is mediated via inflammasome activation by the damage-associated molecular pattern (DAMP), uric acid.	Uric Acid	113-122	interleukin 1 alpha	Homo sapiens	4-12
30468453-7	2018	Inhibition of NF-kappaBp65 by small interfering RNA or specific inhibitor BAY11-7082 blocked IL-1beta-dependent gene upregulation of MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 in a hypoxic environment.	3-(4-methylphenylsulfonyl)-2-propenenitrile	74-84	interleukin 1 alpha	Homo sapiens	93-101
30637441-2	2019	In humans, the induction of IL-1beta production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis.	Uric Acid	56-59	interleukin 1 alpha	Homo sapiens	28-36
30637441-5	2019	Here, we show that resveratrol suppresses secretion of active IL-1beta by human primary monocytes stimulated with MSU crystals through suppression of Syk activation.	Resveratrol	19-30	interleukin 1 alpha	Homo sapiens	62-70
30637441-5	2019	Here, we show that resveratrol suppresses secretion of active IL-1beta by human primary monocytes stimulated with MSU crystals through suppression of Syk activation.	Uric Acid	114-117	interleukin 1 alpha	Homo sapiens	62-70
30255592-0	2019	Different response of human chondrocytes from healthy looking areas and damaged regions to IL1beta stimulation under different oxygen tension.	Oxygen	127-133	interleukin 1 alpha	Homo sapiens	91-98
30909697-3	2019	Recently, advances in biologic therapy enabled blocking of IL-1&amp;#945;, IL-1&amp;#946;, IL-18, and IL-33 with new monoclonal antibodies, soluble receptors, or recombinant binding proteins.	Adenosine Monophosphate	64-67	interleukin 1 alpha	Homo sapiens	59-63
30506883-5	2018	Our results demonstrated that ADMA inhibits insulin sensitivity in a concentration-dependent manner by activating inflammation factors tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in primary hepatocytes.	N,N-dimethylarginine	30-34	interleukin 1 alpha	Homo sapiens	170-188
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	interleukin 1 alpha	Homo sapiens	107-115
30501849-0	2018	IL1-blocking therapy in colchicine-resistant familial Mediterranean fever.	Colchicine	24-34	interleukin 1 alpha	Homo sapiens	0-3
30733764-8	2018	Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells.	kolaviron	0-9	interleukin 1 alpha	Homo sapiens	100-104
30733764-8	2018	Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells.	Selenium	14-22	interleukin 1 alpha	Homo sapiens	100-104
30733764-8	2018	Kolaviron and selenium also reduced hydrogen peroxide-induced secretion of nitric oxide, TNF-alpha, IL-1 and IL-6 by transformed U937 cells.	Hydrogen Peroxide	36-53	interleukin 1 alpha	Homo sapiens	100-104
30595799-0	2018	Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes.	Tryptophan	0-10	interleukin 1 alpha	Homo sapiens	41-45
30404007-3	2018	Stx2/LPS-mediated IL-1beta secretion and pyroptosis are dependent on mitochondrial reactive oxygen species (ROS) downstream of the non-canonical caspase-4 inflammasome and cleaved GSDMD, which is enriched at the mitochondria.	Reactive Oxygen Species	83-106	interleukin 1 alpha	Homo sapiens	18-26
30404007-3	2018	Stx2/LPS-mediated IL-1beta secretion and pyroptosis are dependent on mitochondrial reactive oxygen species (ROS) downstream of the non-canonical caspase-4 inflammasome and cleaved GSDMD, which is enriched at the mitochondria.	Reactive Oxygen Species	108-111	interleukin 1 alpha	Homo sapiens	18-26
29226582-5	2018	In contrast, Y-4 extracts prepared with saline or sesame oil at 37 C and 50 C clearly elicited positive irritation responses, including reduced viability (&lt; 50%) and significantly higher interleukin-1alpha release compared with the solvent alone group, in the RhE tissue model and an intracutaneous response test, where substantial necrosis was observed by histopathology.	Sodium Chloride	40-46	interleukin 1 alpha	Homo sapiens	190-208
30216760-7	2018	Likewise, the silk extracts exhibited a protective effect on the CPZ-induced UVA-phototoxicity in the RhE model, in terms of an improved tissue viability and attenuation of the released inflammatory cytokine, interleukin-1alpha.	Chlorpromazine	65-68	interleukin 1 alpha	Homo sapiens	209-227
29859746-7	2018	Bezafibrate treatment led to a reduction in leukocyte adherence, improved functional capillary density (FCD), and a reduction in interleukin-1alpha (IL-1alpha), tumour necrosis factor alpha (TNF-alpha) and granulocyte macrophage colony stimulating factors (GM-CSF) plasma levels in experimental sepsis.	Bezafibrate	0-11	interleukin 1 alpha	Homo sapiens	129-147
29859746-7	2018	Bezafibrate treatment led to a reduction in leukocyte adherence, improved functional capillary density (FCD), and a reduction in interleukin-1alpha (IL-1alpha), tumour necrosis factor alpha (TNF-alpha) and granulocyte macrophage colony stimulating factors (GM-CSF) plasma levels in experimental sepsis.	Bezafibrate	0-11	interleukin 1 alpha	Homo sapiens	149-158
30390734-37	2018	Nicotinamide can inhibit cytokine release (IL-1, IL-6, IL-8, and TNF-alpha) from immune cells, inhibit chemotaxis and degranulation of immune cells, inhibit lymphocyte blast transformation, and suppress T-cell activity (6).	Niacinamide	0-12	interleukin 1 alpha	Homo sapiens	43-47
30361689-3	2018	Here, we newly established a mouse model in which IL-1 signaling is conditionally activated in adult mice (hIL-1 cTg) and observed phenotypes similar to those seen in auto-inflammatory syndrome patients.	ctg	113-116	interleukin 1 alpha	Homo sapiens	107-112
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	Azithromycin	0-12	interleukin 1 alpha	Homo sapiens	198-206
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	interleukin 1 alpha	Homo sapiens	198-206
30196838-3	2018	In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1beta and TNF-alpha) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10).	honokiol	28-36	interleukin 1 alpha	Homo sapiens	192-200
29775920-1	2018	Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1beta.	Fatty Acids	19-29	interleukin 1 alpha	Homo sapiens	119-127
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interleukin 1 alpha	Homo sapiens	18-27
30098001-0	2018	The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6.	KD025	30-35	interleukin 1 alpha	Homo sapiens	44-48
30015831-8	2018	The results demonstrated that scopoletin treatment markedly decreased MMP-1, IL-1alpha and TNFalpha mRNA expression in fibroblasts stimulated with HaCaT conditioned medium (40 mJ/cm2), without any apparent cell cytotoxicity, and in a dose-dependent manner.	Scopoletin	30-40	interleukin 1 alpha	Homo sapiens	77-86
30217257-8	2018	RESULTS: Honokiol significantly decreased pro-inflammatory cytokine (IL1A, IL6) and chemokine (CXCL8, CXCL1, CCL2) mRNA expression and secretion from fetal membranes (amnion and choriodecidua) and myometrium stimulated with LPS, fsl-1 or poly(I:C).	honokiol	9-17	interleukin 1 alpha	Homo sapiens	69-73
30186471-15	2018	Glutamine can regulate the levels of IL-1 and TNF-alpha, improve lung function, shorten bed rest and hospitalization days, promote patients postoperative rehabilitation process, and improve patients quality of life.	Glutamine	0-9	interleukin 1 alpha	Homo sapiens	37-41
30026080-4	2018	We show that the presence of the dexamethasone prodrug LD003 effectively suppresses production of cytokines such as KC-GRO, TNFalpha, IL-1beta and IL-6 following intravenous administration of LNP loaded with immune stimulatory oligodeoxynucleotides containing cytosine-guanine dinucleotide motifs.	Dexamethasone	33-46	interleukin 1 alpha	Homo sapiens	134-142
29959027-4	2018	Metal-, metal-oxide- and carbon-based nanomaterials may trigger a sterile inflammatory cascade by means of different damage-associated molecular patterns, including chromatin associated protein high-mobility group box-1 secretion, ATP, ADP and adenosine purinergic signaling, interleukin-1alpha alarmin, and NLPR-3 inflammasome activation.	Metals	0-5	interleukin 1 alpha	Homo sapiens	276-294
29959027-4	2018	Metal-, metal-oxide- and carbon-based nanomaterials may trigger a sterile inflammatory cascade by means of different damage-associated molecular patterns, including chromatin associated protein high-mobility group box-1 secretion, ATP, ADP and adenosine purinergic signaling, interleukin-1alpha alarmin, and NLPR-3 inflammasome activation.	metal-oxide	8-19	interleukin 1 alpha	Homo sapiens	276-294
29959027-4	2018	Metal-, metal-oxide- and carbon-based nanomaterials may trigger a sterile inflammatory cascade by means of different damage-associated molecular patterns, including chromatin associated protein high-mobility group box-1 secretion, ATP, ADP and adenosine purinergic signaling, interleukin-1alpha alarmin, and NLPR-3 inflammasome activation.	Carbon	25-31	interleukin 1 alpha	Homo sapiens	276-294
30063943-8	2018	Additionally, the IL-1 level was significantly higher in patients who received a levodopa dosage of >250 mg than in their counterparts who received <=250 mg, and the IL-1 level was higher in patients with an H-Y stage of >2 and UPDRS III of >27 than in their counterparts with an H-Y stage of <=2 and UPDRS III of <=27.	Levodopa	81-89	interleukin 1 alpha	Homo sapiens	18-22
30233225-8	2018	Results: Dextran sulfate strongly and significantly inhibited PMA-induced PGE2 production, inhibited KLK5 and MMP-9 mRNA expression, and IL-8, IL-1alpha and VEGF production, and displayed a highly significant inhibitory effect on VEGF-induced pseudotube formation.	Dextran Sulfate	9-24	interleukin 1 alpha	Homo sapiens	143-152
30280794-11	2018	CoCl2 induction in NCI-H1563 cells led to upregulated levels of IL-13, IL-9, IL-1, and TNF-alpha.	cobaltous chloride	0-5	interleukin 1 alpha	Homo sapiens	64-68
30206205-7	2018	TNFR2/ZVAD-induced production of IL-6 and IL-1beta was largely blocked in necroptosis-resistant MLKL- and RIPK3-deficient macrophages, whereas induction of A20 and TRAF1 remained unaffected.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	6-10	interleukin 1 alpha	Homo sapiens	42-50
29682887-7	2018	Cytokine secretion in response to LPS was variable, with little effect on IL6 secretion, but significantly increased secretion of IL1beta at intermediate Ni(II) concentrations.	Nickel(2+)	154-160	interleukin 1 alpha	Homo sapiens	130-137
29894913-4	2018	The goal of the current study was to engineer cartilage and bone constructs with the ability to inhibit aberrant inflammatory processes caused by the cytokine interleukin-1 (IL-1), through scaffold-mediated delivery of lentiviral particles containing a doxycycline-inducible IL-1 receptor antagonist (IL-1Ra) transgene on anatomically-shaped CDM constructs.	Doxycycline	253-264	interleukin 1 alpha	Homo sapiens	174-178
29894913-4	2018	The goal of the current study was to engineer cartilage and bone constructs with the ability to inhibit aberrant inflammatory processes caused by the cytokine interleukin-1 (IL-1), through scaffold-mediated delivery of lentiviral particles containing a doxycycline-inducible IL-1 receptor antagonist (IL-1Ra) transgene on anatomically-shaped CDM constructs.	Chlorphenamidine	342-345	interleukin 1 alpha	Homo sapiens	174-178
29682887-9	2018	Finally, exposure to eluants from nickel-based commercial alloys caused enhanced IL1beta secretion from PMA-treated cells.	Nickel	34-40	interleukin 1 alpha	Homo sapiens	81-88
29682887-9	2018	Finally, exposure to eluants from nickel-based commercial alloys caused enhanced IL1beta secretion from PMA-treated cells.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 alpha	Homo sapiens	81-88
29651644-4	2018	In the present study, the effect of IL 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim][TfO]) was evaluated on the capacity of PDO production from crude glycerol by microbial consortium DL38-BH.	ethyl-3-methylimidazolium trifluoromethanesulfonate	41-92	interleukin 1 alpha	Homo sapiens	36-40
29939279-0	2018	IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial.	Testosterone	55-67	interleukin 1 alpha	Homo sapiens	0-4
29939279-10	2018	Conclusions: Anti-inflammatory treatment with an antagonist of IL-1 led to an increase in testosterone levels in obese men with testosterone deficiency.	Testosterone	90-102	interleukin 1 alpha	Homo sapiens	63-67
30143600-10	2018	Furthermore, PN blocked 6-OHDA-induced NF-kappaB activation and IL-1beta expression.	Oxidopamine	24-30	interleukin 1 alpha	Homo sapiens	64-72
29951691-3	2018	Secretion of both interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) from human lymphocytes can be increased dependent upon the level of TBT exposure.	tributyltin	140-143	interleukin 1 alpha	Homo sapiens	37-45
29951691-5	2018	Furthermore, the data indicate that these TBT-induced increases in IL-1beta and IL-6 synthesis require MAP kinase signaling pathways.	tributyltin	42-45	interleukin 1 alpha	Homo sapiens	67-75
29951691-6	2018	Additionally, elevated synthesis of IL-1beta and IL-6 seen at the highest exposures to TBT (200, 200, 50 nM) were accompanied by increases in the mRNA for these cytokines.	tributyltin	87-90	interleukin 1 alpha	Homo sapiens	36-44
29951691-7	2018	TBT-induced increases in IL-1beta and IL-6 mRNAs were also shown to be dependent on MAP kinase signaling.	tributyltin	0-3	interleukin 1 alpha	Homo sapiens	25-33
29651644-4	2018	In the present study, the effect of IL 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim][TfO]) was evaluated on the capacity of PDO production from crude glycerol by microbial consortium DL38-BH.	tfo	101-104	interleukin 1 alpha	Homo sapiens	36-40
30071694-3	2018	We used a burn injury setting in humans and a burn injury model in animals in order to examine the effects on the bone of the systemic inflammatory response and identified the parathyroid calcium-sensing receptor as the mediator of increasing bone resorption, hence higher interleukin (IL)-1 production, and decreasing bone resorption, hence the lowering of circulating ionized calcium concentration.	Calcium	188-195	interleukin 1 alpha	Homo sapiens	273-291
29651644-4	2018	In the present study, the effect of IL 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim][TfO]) was evaluated on the capacity of PDO production from crude glycerol by microbial consortium DL38-BH.	Glycerol	166-174	interleukin 1 alpha	Homo sapiens	36-40
30069732-6	2018	Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-alpha antagonists.	Steroids	14-21	interleukin 1 alpha	Homo sapiens	130-134
29981275-2	2018	Anti-interleukin-1 drugs emerge as a therapeutic option for colchicine-resistant patients.	Colchicine	60-70	interleukin 1 alpha	Homo sapiens	5-18
30069732-6	2018	Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-alpha antagonists.	Methotrexate	27-39	interleukin 1 alpha	Homo sapiens	130-134
29906742-6	2018	The levels of TNF-alpha, IL-1ss and IL-6 in kidney tissues were suppressed by xanthohumol.	xanthohumol	78-89	interleukin 1 alpha	Homo sapiens	25-29
29574654-7	2018	Here, we show that two novel SERMs and raloxifene affect immune cells by promoting M2 macrophage phenotype, alleviating NFkappaB activity, inhibiting T cell proliferation, and stimulating the production of anti-inflammatory compounds such as IL10 and IL1 receptor antagonist.	Raloxifene Hydrochloride	39-49	interleukin 1 alpha	Homo sapiens	242-245
29551335-6	2018	Increasing intracellular calcium synergized both LPS- and Pam3CSK4-induced IL-1alpha protein production.	Calcium	25-32	interleukin 1 alpha	Homo sapiens	75-84
29967942-11	2018	In DSS-induced colitis, anti-TNFalpha treatment reduced mucosal immune cell infiltration and expression of the pro-inflammatory cytokines IL-1beta and TNFalpha.	Dextran Sulfate	3-6	interleukin 1 alpha	Homo sapiens	138-146
29987285-4	2018	by dissolving (IL-1,2-tpbd)+NTf2- in a room temperature ionic liquid, 1-hexyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ((C6mim)+NTf2-).	1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide	70-132	interleukin 1 alpha	Homo sapiens	15-19
29987285-9	2018	Furthermore, (IL-1,2-tpbd)+NTf2- showed a higher preference for Cd2+ even under the interference of various co-existing metal ions.	Metals	120-125	interleukin 1 alpha	Homo sapiens	14-18
28992387-8	2018	Anti-IL-1 treatment was used because of colchicine-resistant disease in 84% and amyloidosis in 12% of subjects.	Colchicine	40-50	interleukin 1 alpha	Homo sapiens	5-9
28992387-11	2018	CONCLUSION: Anti-IL-1 treatment is an effective alternative for controlling attacks and decreasing proteinuria in colchicine-resistant FMF patients.	Colchicine	114-124	interleukin 1 alpha	Homo sapiens	17-21
29859292-9	2018	RESULTS: A multiple-SNP analysis showed TC haplotype for IL1A and IL1B SNPs to be significantly associated with a decreased risk of the parasitic infection (OR 0.41, P&lt;=0.050).	Technetium	40-42	interleukin 1 alpha	Homo sapiens	57-61
29973533-5	2018	Kahweol decreased the LPS-induced production of interleukin 1 alpha, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha.	kahweol	0-7	interleukin 1 alpha	Homo sapiens	48-67
29896269-12	2018	In addition, IL-1and TNF-alpha were downregulated, while IL-6 and SOD were upregulated in patients with cognitive dysfunction after treatment with DEX compared with those in the placebo group.	Dexmedetomidine	147-150	interleukin 1 alpha	Homo sapiens	13-17
29551335-7	2018	Accordingly, blocking calcium signaling and calpain activity strongly suppressed IL-1alpha protein expression.	Calcium	22-29	interleukin 1 alpha	Homo sapiens	81-90
29551335-11	2018	Interestingly, all inhibitors targeting the PI3K/Akt pathway, with the exception of Ly294002, strongly increased IL-1alpha protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	interleukin 1 alpha	Homo sapiens	113-122
29551335-12	2018	This study improves understanding of the complex mechanisms regulating IL-1alpha protein expression in hRPE cells by demonstrating that TLR4 and TLR2 stimulation and exposure to IL-1beta, ER stress and intracellular calcium all induce hRPE cells to produce intracellular IL-1alpha, which is negatively regulated by the PI3K/Akt pathway.	Calcium	216-223	interleukin 1 alpha	Homo sapiens	71-80
29941796-7	2018	Of particular interest are three hallmark cytokines, IL-6, TNF&amp;alpha; and IL-1&amp;beta;, which have been studied extensively in basic research, cell-receptor signaling and drug development.	Adenosine Monophosphate	83-86	interleukin 1 alpha	Homo sapiens	78-82
29039020-8	2018	In intra-group comparison, aMCI and mild AD with detectable levels of cytokines (TNF-alpha, IL-1beta, IL-10, and IL-12) had decreased DMN FC.	amci	27-31	interleukin 1 alpha	Homo sapiens	92-100
30016181-13	2018	As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways.	Heparin	13-16	interleukin 1 alpha	Homo sapiens	39-47
29107116-2	2018	Studies have demonstrated that loss of autophagy/mitophagy can lead to a build-up of cytosolic reactive oxygen species and mitochondrial DNA, which can, in turn, activate immune signalling pathways that ultimately lead to the releases of inflammatory cytokines, including IL-1alpha, IL-1beta, IL-18, type I IFN and macrophage migration inhibitory factor (MIF).	Reactive Oxygen Species	95-118	interleukin 1 alpha	Homo sapiens	272-281
29941796-8	2018	The field of inflammasome-mediated neuroinflammation is an emerging area of MDD research that is providing new cellular insight into how macrophages mechanistically support cytokine-associated neuropathology, particularly in the case of IL-1&amp;beta;-associated inflammation in MDD.	Adenosine Monophosphate	242-245	interleukin 1 alpha	Homo sapiens	237-241
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	interleukin 1 alpha	Homo sapiens	190-198
29502208-7	2018	RNA sequencing identified the IL-1alpha pathway as a potential molecular mechanism responsible for tumor promotion by TAMC.	tamc	118-122	interleukin 1 alpha	Homo sapiens	30-39
29502208-8	2018	Inhibition of IL-1alpha delayed growth of TAMC-induced tumors.	tamc	42-46	interleukin 1 alpha	Homo sapiens	14-23
29492824-0	2018	Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1beta Production in Microglia.	Methamphetamine	27-42	interleukin 1 alpha	Homo sapiens	89-97
29492824-6	2018	It is our hypothesis that Meth activates NLRP3 inflammasome in microglia and promotes the processing and release of interleukin (IL)-1beta, resulting in neurotoxic activity.	Methamphetamine	26-30	interleukin 1 alpha	Homo sapiens	116-138
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	hesperetin	54-64	interleukin 1 alpha	Homo sapiens	190-198
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	epigallocatechin gallate	66-92	interleukin 1 alpha	Homo sapiens	190-198
29584915-6	2018	In patients with established HF, IL-1 is thought to impair beta-adrenergic receptor signalling and intracellular calcium handling.	Calcium	113-120	interleukin 1 alpha	Homo sapiens	33-37
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	interleukin 1 alpha	Homo sapiens	190-198
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Genistein	43-52	interleukin 1 alpha	Homo sapiens	190-198
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	22-24	interleukin 1 alpha	Homo sapiens	175-183
30307173-3	2018	In this article, we explore the nature of density fluctuations associated with capillary evaporation of the IL 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]) in the confined region of model solvophobic nanoscale sheets by using molecular dynamics simulations combined with non-Boltzmann sampling techniques.	ethyl-3-methylimidazolium tetrafluoroborate	113-156	interleukin 1 alpha	Homo sapiens	108-112
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	interleukin 1 alpha	Homo sapiens	175-183
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	interleukin 1 alpha	Homo sapiens	175-183
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	interleukin 1 alpha	Homo sapiens	175-183
29543732-6	2018	IS promoted phosphorylation of NF-kappaB p65 and MAPK enzymes; the reaction and IL-1 expression were inhibited by BAY11-7082, an inhibitor of NF-kappaB.	3-(4-methylphenylsulfonyl)-2-propenenitrile	114-124	interleukin 1 alpha	Homo sapiens	80-84
29751535-7	2018	Furthermore, IL-1&amp;beta;-stimulated SW982 cells secreted less inflammatory cytokines (TNF-&amp;alpha; and IL-6), which is associated with the downregulation of p38-mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and NF-&amp;kappa;B pathways.	Adenosine Monophosphate	18-21	interleukin 1 alpha	Homo sapiens	13-17
29218493-6	2018	On the other hand, we detected a downregulation of matrix metalloproteinases (e.g., MMP3), differentiation markers (e.g., LOR and S100A7), and the pro-inflammatory cytokine IL1alpha.Overall, our findings substantiate the understanding of time-dependent molecular changes after CO2 laser treatment.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	277-280	interleukin 1 alpha	Homo sapiens	173-181
29712950-6	2018	IL-1alpha-primed ARPE-19 cells, human embryonal stem cell (hESC)-derived RPE cells, and primary human RPE cells were exposed to MG-132 and bafilomycin A to activate NLRP3 via the inhibition of proteasomes and autophagy, respectively.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	128-134	interleukin 1 alpha	Homo sapiens	0-9
29712950-6	2018	IL-1alpha-primed ARPE-19 cells, human embryonal stem cell (hESC)-derived RPE cells, and primary human RPE cells were exposed to MG-132 and bafilomycin A to activate NLRP3 via the inhibition of proteasomes and autophagy, respectively.	bafilomycin A	139-152	interleukin 1 alpha	Homo sapiens	0-9
29675024-5	2018	Then, we found that peripheral blood mononuclear cells (PBMCs) from IPF patients released IL-1alpha and IL-18 in a NLRP3- and calpain-independent manner after LPS +- ATP stimulation.	Adenosine Triphosphate	166-169	interleukin 1 alpha	Homo sapiens	90-99
29380034-6	2018	In the absence of an airway insult, we expected to find no evidence of airway inflammation; however, transcripts for several asthma-associated cytokines, including IL17A, IL1A, and IL8, were elevated in the tracheas of bethanechol-treated piglets.	Bethanechol	219-230	interleukin 1 alpha	Homo sapiens	171-175
29806827-7	2018	Pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-alpha), and interleukin 1 alpha (IL-1alpha) were significantly increased in human PCLS after exposure to a sub-toxic concentration of HClPt.	pcls	143-147	interleukin 1 alpha	Homo sapiens	73-92
29806827-7	2018	Pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-alpha), and interleukin 1 alpha (IL-1alpha) were significantly increased in human PCLS after exposure to a sub-toxic concentration of HClPt.	pcls	143-147	interleukin 1 alpha	Homo sapiens	94-103
29720213-11	2018	ROS was required for PM2.5-induced IL-1beta production and NLRP3 inflammasome activation in oAbeta-stimulated microglia.	ros	0-3	interleukin 1 alpha	Homo sapiens	35-43
30034189-0	2018	Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells.	Minoxidil	0-9	interleukin 1 alpha	Homo sapiens	24-43
30034189-5	2018	We investigated the in vitro expression levels of cytokine interleukin-1 alpha (IL-1alpha), a potent inhibitor of hair growth, in minoxidil-treated human keratinocyte (HaCaT) cells to determine whether this molecule exerts anti-inflammatory effects.	Minoxidil	130-139	interleukin 1 alpha	Homo sapiens	59-78
30034189-5	2018	We investigated the in vitro expression levels of cytokine interleukin-1 alpha (IL-1alpha), a potent inhibitor of hair growth, in minoxidil-treated human keratinocyte (HaCaT) cells to determine whether this molecule exerts anti-inflammatory effects.	Minoxidil	130-139	interleukin 1 alpha	Homo sapiens	80-89
30034189-11	2018	Minoxidil treatment downregulated IL-1alpha expression by 0.3433-fold compared with untreated cells (P = 0.001).	Minoxidil	0-9	interleukin 1 alpha	Homo sapiens	34-43
30034189-12	2018	Conclusion: This anti-inflammatory effect of minoxidil, as evidenced by significant downregulation of IL-1alpha gene expression in HaCaT cells, may represent one of its mechanisms of action in alopecia.	Minoxidil	45-54	interleukin 1 alpha	Homo sapiens	102-111
29611404-11	2018	Also, miR-212 alleviated MPP+-induced SH-SY5Y cell damage, embodied by increased cell viability, decreased caspase-3 activity, LDH release, ROS production, TNF-alpha, and IL-1beta expression, as well as elevated SOD levels.	mangion-purified polysaccharide (Candida albicans)	25-29	interleukin 1 alpha	Homo sapiens	171-179
29420357-6	2018	On reexamination, previously drug-naive AD patients who received donepezil treatment for 6 months displayed a decrease in cell-derived IFN-gamma, TNF-alpha, IL-1beta, and IL-6.	Donepezil	65-74	interleukin 1 alpha	Homo sapiens	157-165
30302033-9	2018	HE solution caused statistically significant downregulation of IL-1alpha gene expressions (p&lt;0.0001), compared to untreated control cells.	Helium	0-2	interleukin 1 alpha	Homo sapiens	63-72
29562405-11	2018	Conclusions: In total arch replacement, intravenous penehyclidine hydrochloride injection may decrease the release of serum TNF-alpha, IL-6, IL-1, improve oxygenation index, reduce lung ischemia-reperfusion injury, shorten the time of ventilator support and ICU stay after operation, and thus improve the prognosis of patients.	Penequine hydrochloride	52-79	interleukin 1 alpha	Homo sapiens	141-145
29406582-4	2018	ADE normalized levels of interleukin (IL)-6, tumor necrosis factor-alpha, and IL-1beta were significantly higher for AD patients than controls, but there was greater overlap between the two groups than for complement proteins.	Adenine	0-3	interleukin 1 alpha	Homo sapiens	78-86
29151582-0	2018	IL-1alpha in acetaminophen toxicity: a sterile danger signal.	Acetaminophen	13-26	interleukin 1 alpha	Homo sapiens	0-9
30138927-10	2018	RESULTS: Elevated extracellular potassium prevented the priming factor IL-1alpha from inducing the production of reactive oxygen species (ROS).	Potassium	32-41	interleukin 1 alpha	Homo sapiens	71-80
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	triterpenoids	93-106	interleukin 1 alpha	Homo sapiens	146-164
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	ursolic acid	126-138	interleukin 1 alpha	Homo sapiens	146-164
29444596-3	2018	Here, we evaluated whether activation of cannabinoid receptor 1 using its selective agonist arachidonyl-2-chloroethylamide had an influence on cellular senescence induced by interleukin-1betain human chondrocytes.	arachidonyl-2-chloroethylamide	92-122	interleukin 1 alpha	Homo sapiens	174-187
29155016-3	2018	In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes.	methyl 4-(adenin-9-yl)-2-hydroxybutanoate	47-53	interleukin 1 alpha	Homo sapiens	155-164
29273420-7	2018	However, when the mixture of PPD/H2O2/RES and PPD/H2O2 was applied to the RhE, some of the parameters such as morphological changes including the presence of apoptotic cells, barrier loss and increased IL- 1 alpha release were observed.	Hydrogen Peroxide	33-37	interleukin 1 alpha	Homo sapiens	202-213
29273420-7	2018	However, when the mixture of PPD/H2O2/RES and PPD/H2O2 was applied to the RhE, some of the parameters such as morphological changes including the presence of apoptotic cells, barrier loss and increased IL- 1 alpha release were observed.	resorcinol	38-41	interleukin 1 alpha	Homo sapiens	202-213
30270324-6	2018	Moreover, sacran restored the elevation of intracellular reactive oxygen species (ROS) levels stimulated by SLS and by IL-1alpha.	sacran	10-16	interleukin 1 alpha	Homo sapiens	119-128
30270324-6	2018	Moreover, sacran restored the elevation of intracellular reactive oxygen species (ROS) levels stimulated by SLS and by IL-1alpha.	Reactive Oxygen Species	57-80	interleukin 1 alpha	Homo sapiens	119-128
30270324-6	2018	Moreover, sacran restored the elevation of intracellular reactive oxygen species (ROS) levels stimulated by SLS and by IL-1alpha.	Reactive Oxygen Species	82-85	interleukin 1 alpha	Homo sapiens	119-128
30138927-10	2018	RESULTS: Elevated extracellular potassium prevented the priming factor IL-1alpha from inducing the production of reactive oxygen species (ROS).	Reactive Oxygen Species	113-136	interleukin 1 alpha	Homo sapiens	71-80
30527801-4	2018	Recent work suggests an intriguing interaction between oxidized phospholipids on Lp(a) and inflammatory interleukin-1 genotypes.	Phospholipids	64-77	interleukin 1 alpha	Homo sapiens	104-117
29245201-8	2018	Postoperative levels of IL1-ss and IL-6 were lower in the allopurinol group.	Allopurinol	58-69	interleukin 1 alpha	Homo sapiens	24-27
29080912-7	2018	Further studies demonstrated that pre- plus co-treatment with 15 muM baicalin significantly inhibited proinflammatory factor IL-1alpha and ELAM-1 production, decreased activities of senescence marker SA-beta-gal, and lowered carbonylated protein levels.	baicalin	69-77	interleukin 1 alpha	Homo sapiens	125-134
29059561-7	2018	CPF produced a strong induction of IL6, while TCP exposure resulted in a strong induction of IL1alpha.	tcp	46-49	interleukin 1 alpha	Homo sapiens	93-101
29398714-1	2018	Abstract: The exposure of HeLa cells to interleukin-1 alpha (IL-1alpha) in the presence of cycloheximide (CHX) leads to the release of active tumor necrosis factor alpha (TNF-alpha), eliciting cytocidal effect on these cells.	Cycloheximide	91-104	interleukin 1 alpha	Homo sapiens	40-59
29398714-1	2018	Abstract: The exposure of HeLa cells to interleukin-1 alpha (IL-1alpha) in the presence of cycloheximide (CHX) leads to the release of active tumor necrosis factor alpha (TNF-alpha), eliciting cytocidal effect on these cells.	Cycloheximide	91-104	interleukin 1 alpha	Homo sapiens	61-70
29398714-1	2018	Abstract: The exposure of HeLa cells to interleukin-1 alpha (IL-1alpha) in the presence of cycloheximide (CHX) leads to the release of active tumor necrosis factor alpha (TNF-alpha), eliciting cytocidal effect on these cells.	Cycloheximide	106-109	interleukin 1 alpha	Homo sapiens	40-59
29398714-1	2018	Abstract: The exposure of HeLa cells to interleukin-1 alpha (IL-1alpha) in the presence of cycloheximide (CHX) leads to the release of active tumor necrosis factor alpha (TNF-alpha), eliciting cytocidal effect on these cells.	Cycloheximide	106-109	interleukin 1 alpha	Homo sapiens	61-70
29424905-11	2018	The level of serum E2 in the experimental group was positively correlated with the levels of IL-1, IL-6 and TNF-alpha in synovial fluid (p<0.05).	Estradiol	19-21	interleukin 1 alpha	Homo sapiens	93-97
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	98-102	interleukin 1 alpha	Homo sapiens	116-124
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	98-102	interleukin 1 alpha	Homo sapiens	337-346
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	103-107	interleukin 1 alpha	Homo sapiens	116-124
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	103-107	interleukin 1 alpha	Homo sapiens	337-346
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	103-107	interleukin 1 alpha	Homo sapiens	116-124
29196167-3	2018	Here we demonstrated cathepsin B (CTSB) as a regulator of the activation of NLRP3 inflammasome by H2O2 H2O2 induced IL-1beta secretion in NLRP3 inflammasome-dependent manner H2O2 treatment increased CTSB activity, which in turn activated NLRP3 inflammasome, and subsequently processed pro-caspase-1 cleavage into caspase-1, resulting in IL-1 beta secretion.	Hydrogen Peroxide	103-107	interleukin 1 alpha	Homo sapiens	337-346
29196167-4	2018	Genetic inhibition or pharmacological inhibition of CTSB blocked the cleavage of pro-caspase-1 into caspase-1 and subsequent IL-1 beta secretion induced by H2O2.	Hydrogen Peroxide	156-160	interleukin 1 alpha	Homo sapiens	125-134
29107864-8	2018	The results demonstrated that in the absence of intracellular calcium, caspase-1 cannot be activated and therefore the level of IL-1beta decreases.	Calcium	62-69	interleukin 1 alpha	Homo sapiens	128-136
29275239-5	2018	At the non photocytotoxic dose PFLX, shows reduced phagocytosis activity, NO (nitric oxide) production, large vacuole formation and down regulated IL-6, TNF-alpha and IL-1 in BALB/c macrophages at both genes and proteins levels.	Pefloxacin	31-35	interleukin 1 alpha	Homo sapiens	167-171
29874670-1	2018	AIMS: The purpose of this paper was to determine the lacrimal concentration of IL-1alpha and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline.	Azithromycin	179-191	interleukin 1 alpha	Homo sapiens	79-88
29874670-1	2018	AIMS: The purpose of this paper was to determine the lacrimal concentration of IL-1alpha and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline.	Doxycycline	195-206	interleukin 1 alpha	Homo sapiens	79-88
29874670-4	2018	IL-1alpha decreased from 47.0 pg/mL before azithromycin to 23.5 pg/mL after treatment (p = 0.024), but not after doxycycline therapy.	Azithromycin	43-55	interleukin 1 alpha	Homo sapiens	0-9
29874670-6	2018	There was a strong clinical correlation of higher baseline IL-1alpha tear levels between patients who responded to doxycycline therapy and those who failed (p = 0.043).	Doxycycline	115-126	interleukin 1 alpha	Homo sapiens	59-68
29874670-8	2018	CONCLUSIONS: While IL-1alpha levels decreased after azithromycin therapy, MMP-9 did so after doxycycline treatment.	Azithromycin	52-64	interleukin 1 alpha	Homo sapiens	19-28
30110695-7	2018	Significant increases in IL-1alpha, IL-1RA, and IL-1beta were observed after cream application at sites treated with polymer A.	polymer a	117-126	interleukin 1 alpha	Homo sapiens	25-34
29061850-7	2017	Furthermore, in both mouse and human macrophages, TcpB attenuated LPS-induced non-canonical inflammasome activation and suppressed pyroptosis and secretion of IL-1alpha and IL-1beta induced by intracellular LPS delivery.	TCPB	50-54	interleukin 1 alpha	Homo sapiens	159-168
29131962-2	2017	Both the up-shifts of the core-level binding energy and the lowering of the work function DeltaPhi reveal that heating of a monolayer of the battery-relevant ionic liquid (IL) 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide ([BMP]+[TFSI]-) adsorbed on lithiated graphite at 80 K to &gt;230 K facilitates an accumulation of partially charged Lidelta+ atoms at the IL-graphite(0001) interface.	1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide	184-240	interleukin 1 alpha	Homo sapiens	158-177
29131962-2	2017	Both the up-shifts of the core-level binding energy and the lowering of the work function DeltaPhi reveal that heating of a monolayer of the battery-relevant ionic liquid (IL) 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide ([BMP]+[TFSI]-) adsorbed on lithiated graphite at 80 K to &gt;230 K facilitates an accumulation of partially charged Lidelta+ atoms at the IL-graphite(0001) interface.	tfsi	249-253	interleukin 1 alpha	Homo sapiens	158-177
29131962-2	2017	Both the up-shifts of the core-level binding energy and the lowering of the work function DeltaPhi reveal that heating of a monolayer of the battery-relevant ionic liquid (IL) 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide ([BMP]+[TFSI]-) adsorbed on lithiated graphite at 80 K to &gt;230 K facilitates an accumulation of partially charged Lidelta+ atoms at the IL-graphite(0001) interface.	Graphite	279-287	interleukin 1 alpha	Homo sapiens	158-177
29131962-2	2017	Both the up-shifts of the core-level binding energy and the lowering of the work function DeltaPhi reveal that heating of a monolayer of the battery-relevant ionic liquid (IL) 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide ([BMP]+[TFSI]-) adsorbed on lithiated graphite at 80 K to &gt;230 K facilitates an accumulation of partially charged Lidelta+ atoms at the IL-graphite(0001) interface.	Graphite	383-391	interleukin 1 alpha	Homo sapiens	158-177
29207489-2	2017	In the present study, we demonstrated that quinacrine decreased the expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1) alpha in human lung adenocarcinoma A549 cells.	Quinacrine	43-53	interleukin 1 alpha	Homo sapiens	174-187
29207489-2	2017	In the present study, we demonstrated that quinacrine decreased the expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1) alpha in human lung adenocarcinoma A549 cells.	Quinacrine	43-53	interleukin 1 alpha	Homo sapiens	189-200
29207489-3	2017	Quinacrine inhibited ICAM-1 mRNA expression and nuclear factor kappaB (NF-kappaB)-responsive luciferase reporter activity following a treatment with TNF-alpha and IL-1alpha.	Quinacrine	0-10	interleukin 1 alpha	Homo sapiens	163-172
29200759-7	2017	In cultured keratinocytes, the RA combination significantly decreased cell viability, but increased cytotoxicity and extracellular interleukin 1 alpha release with corresponding doses of HQ.	Tretinoin	31-33	interleukin 1 alpha	Homo sapiens	131-150
28627263-8	2017	Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.	Triglycerides	64-77	interleukin 1 alpha	Homo sapiens	6-11
28627263-8	2017	Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.	Cholesterol	85-96	interleukin 1 alpha	Homo sapiens	6-11
30138927-10	2018	RESULTS: Elevated extracellular potassium prevented the priming factor IL-1alpha from inducing the production of reactive oxygen species (ROS).	Reactive Oxygen Species	138-141	interleukin 1 alpha	Homo sapiens	71-80
30647695-9	2017	On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB.	Selenium	19-21	interleukin 1 alpha	Homo sapiens	90-94
30647695-9	2017	On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB.	Glycine	26-29	interleukin 1 alpha	Homo sapiens	90-94
30647695-9	2017	On the other hand, Se and GLY reduced hydrogen peroxide-mediated production of TNF-alpha, IL-1, IL-6 and expression of iNOS and NF-kappaB.	Hydrogen Peroxide	38-55	interleukin 1 alpha	Homo sapiens	90-94
28964890-9	2017	ABT-981 significantly reduced absolute neutrophil count and serum concentrations of IL-1alpha/IL-1beta, high-sensitivity C-reactive protein, and matrix metalloproteinase (MMP)-derived type 1 collagen.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 alpha	Homo sapiens	84-93
29053870-4	2017	Compared to the birds injected with PBS, LPS injection upregulated cathelicidin and IL-1 relative mRNA amounts in monocytes from birds fed 100 mg Zn+90 mg Mn, both in sulfate and OHCl form, and in birds fed 50 mg ZnOHCl+45 mg MnOHCl, but not in the birds fed 50 mg ZnSO4+45 mg MnSO4.	Zinc	146-148	interleukin 1 alpha	Homo sapiens	84-88
29157812-9	2017	Screening of MAP kinase phosphorylation showed a combined activation of IL-1alpha/AKBA on JNK, while the JNK inhibitor SP600125 abolished MMP-9 upregulation induced by IL-1alpha/AKBA.	pyrazolanthrone	119-127	interleukin 1 alpha	Homo sapiens	168-177
29157812-11	2017	Conversely, the extract inhibits the IL-1alpha effect at low doses, but not at higher ones, where AKBA and possibly other beta-boswellic acids reach concentrations that potentiate the effect of IL-1alpha.	boswellic acid	122-142	interleukin 1 alpha	Homo sapiens	194-203
29053870-8	2017	In conclusion, birds fed diets with lower amounts of zinc and manganese in sulfate form decreased SOD activity and IL-1 and cathelicidin amounts during inflammation, and either increasing the dietary zinc and manganese content or feeding zinc and manganese in OHCl form synergistically increased the SOD activity and IL-1 and cathelicidin mRNA amounts in immune cells.	Manganese	62-71	interleukin 1 alpha	Homo sapiens	115-119
29053870-8	2017	In conclusion, birds fed diets with lower amounts of zinc and manganese in sulfate form decreased SOD activity and IL-1 and cathelicidin amounts during inflammation, and either increasing the dietary zinc and manganese content or feeding zinc and manganese in OHCl form synergistically increased the SOD activity and IL-1 and cathelicidin mRNA amounts in immune cells.	Manganese	62-71	interleukin 1 alpha	Homo sapiens	317-321
29142506-8	2017	Glycated hemoglobin levels measured after 6-month glucose-lowering treatment appeared to be inversely correlated with plasma anti-IL1alpha IgG (r=-0.477, df=17, p=0.039) and anti-IL6 IgG (r=-0.519, df=17, p=0.023) although such correlation failed to survive the Bonferroni correction.	Glucose	50-57	interleukin 1 alpha	Homo sapiens	130-138
29053870-8	2017	In conclusion, birds fed diets with lower amounts of zinc and manganese in sulfate form decreased SOD activity and IL-1 and cathelicidin amounts during inflammation, and either increasing the dietary zinc and manganese content or feeding zinc and manganese in OHCl form synergistically increased the SOD activity and IL-1 and cathelicidin mRNA amounts in immune cells.	Sulfates	75-82	interleukin 1 alpha	Homo sapiens	115-119
29201182-1	2017	This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels.	gastrodin	37-46	interleukin 1 alpha	Homo sapiens	208-227
29142375-9	2017	Reduced levels of IL-1, IL-6, TNF-alpha, IFN, and CRP were observed in the atorvastatin group.	Atorvastatin	75-87	interleukin 1 alpha	Homo sapiens	18-22
28916975-0	2017	Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-gamma, LP(a), IL-1 and TNF-alpha in Type 2 Diabetic Patients with Coronary Heart Disease.	Linseed Oil	0-12	interleukin 1 alpha	Homo sapiens	82-86
28916975-6	2017	In addition, compared with the placebo, taking flaxseed oil supplements down-regulated gene expression levels of lipoprotein(a) [LP(a)] (P = 0.001), interleukin-1 (IL-1) (P = 0.001) and tumor necrosis factor alpha (TNF-alpha) (P = 0.02) in PBMC of diabetic patients with CHD.	Linseed Oil	47-59	interleukin 1 alpha	Homo sapiens	149-169
28916975-8	2017	Overall, flaxseed oil supplementation for 12 weeks in diabetic patients with CHD significantly improved gene expression levels of PPAR-gamma, LP(a), IL-1 and TNF-alpha, but did not influence LDLR, IL-8 and TGF-beta.	Linseed Oil	9-21	interleukin 1 alpha	Homo sapiens	149-153
28993621-5	2017	The IL-1alpha/aptamer interface is composed of unusual polar and hydrophobic elements, along with an elaborate hydrogen bonding network that is mediated by sodium ion.	Hydrogen	111-119	interleukin 1 alpha	Homo sapiens	4-13
28993621-5	2017	The IL-1alpha/aptamer interface is composed of unusual polar and hydrophobic elements, along with an elaborate hydrogen bonding network that is mediated by sodium ion.	Sodium	156-162	interleukin 1 alpha	Homo sapiens	4-13
28993621-7	2017	Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1alpha, present the structure of the IL-1alpha/aptamer complex and show that this aptamer inhibits the IL-1alpha signaling pathway.	selex	21-26	interleukin 1 alpha	Homo sapiens	87-96
28993621-7	2017	Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1alpha, present the structure of the IL-1alpha/aptamer complex and show that this aptamer inhibits the IL-1alpha signaling pathway.	selex	21-26	interleukin 1 alpha	Homo sapiens	127-136
28993621-7	2017	Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1alpha, present the structure of the IL-1alpha/aptamer complex and show that this aptamer inhibits the IL-1alpha signaling pathway.	selex	21-26	interleukin 1 alpha	Homo sapiens	127-136
28539262-10	2017	In conclusion, we provide evidence that anti-endotoxin peptides inhibit the inflammasome/IL-1 axis induced by cytoplasmic LPS sensing in myeloid cells and keratinocytes and activation of the classical inflammasome by LPS/ATP which may contribute to the protection against bacterial sepsis and skin infections with intracellular Gram-negative bacteria.	Adenosine Triphosphate	221-224	interleukin 1 alpha	Homo sapiens	89-93
28608600-9	2017	RESULTS: There was a positive correlation between IL-1alpha, which was upregulated during hypoxia, and tumor stage, lymph node metastasis and resistance to cisplatin in GC.	Cisplatin	156-165	interleukin 1 alpha	Homo sapiens	50-59
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	nw-pm2	13-19	interleukin 1 alpha	Homo sapiens	156-174
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	nw-pm2	13-19	interleukin 1 alpha	Homo sapiens	176-185
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	w-pm2	14-19	interleukin 1 alpha	Homo sapiens	156-174
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	w-pm2	14-19	interleukin 1 alpha	Homo sapiens	176-185
27925185-10	2017	The increased deacetylation processes due to carbocysteine and beclomethasone dipropionate incubation is associated to reduced p-CREB, IL-1 m-RNA expression, neutrophil chemotaxis.	Carbocysteine	45-58	interleukin 1 alpha	Homo sapiens	135-139
27925185-10	2017	The increased deacetylation processes due to carbocysteine and beclomethasone dipropionate incubation is associated to reduced p-CREB, IL-1 m-RNA expression, neutrophil chemotaxis.	Beclomethasone	63-90	interleukin 1 alpha	Homo sapiens	135-139
28828907-6	2017	PASMC have reduced inflammatory activation in response to IL-1ss compared with AoSMCs; however, PASMC with reduced BMPR2 demonstrated an exaggerated response.	pasmc	0-5	interleukin 1 alpha	Homo sapiens	58-62
28757235-5	2017	For each anti-IL-1 agent used, a table shows the frequency of remission during treatment and the frequency of stopping or reducing steroid use, which were reported in almost all articles.	Steroids	131-138	interleukin 1 alpha	Homo sapiens	14-18
28757235-13	2017	There is substantial evidence that anti-IL-1 agents have a strong steroid-sparing effect and considerable evidence that the use of disease-modifying anti-rheumatic drugs can also be reduced or stopped.	Steroids	66-73	interleukin 1 alpha	Homo sapiens	40-44
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	315-333
28567492-6	2017	Exposure of human epidermal equivalents (HEEs) to the UFFA oleic acid (OA), also present in sebum, led to barrier impairment associated with increased SC lipid disorder, increased secretion of interleukin-1alpha (IL-1alpha), and excessive SC thickening.	uffa oleic acid	54-69	interleukin 1 alpha	Homo sapiens	193-211
28567492-6	2017	Exposure of human epidermal equivalents (HEEs) to the UFFA oleic acid (OA), also present in sebum, led to barrier impairment associated with increased SC lipid disorder, increased secretion of interleukin-1alpha (IL-1alpha), and excessive SC thickening.	uffa oleic acid	54-69	interleukin 1 alpha	Homo sapiens	213-222
28919708-11	2017	AOS treatment reduced the levels of miR-29b, TLR4, mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-kappa B), interleukin 1 (IL-1) beta, and interleukin 6 (IL-6).	D-(+)-ALLOSE	0-3	interleukin 1 alpha	Homo sapiens	129-142
28629997-5	2017	Treatment with IL-1alpha, but not IL-1beta or TNFalpha, increased the number of cells responding to allyl isothiocyanate, a TRPA1 agonist, in a dose- and time-dependent manner.	allyl isothiocyanate	100-120	interleukin 1 alpha	Homo sapiens	15-24
28629997-6	2017	The IL-1alpha-induced increase of TRPA1 responsiveness was inhibited by an extracellular-regulated kinase (Erk) inhibitor (PD98059) but not by inhibitors of c-Jun kinase, p38 mitogen-activated protein kinase or phosphatidylinositol-3 kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	123-130	interleukin 1 alpha	Homo sapiens	4-13
28793896-2	2017	MEDI8968, a fully human monoclonal antibody, binds selectively to IL-1R1, inhibiting activation by IL-1alpha and IL-1beta.	medi8968	0-8	interleukin 1 alpha	Homo sapiens	99-108
28868047-0	2017	In Premature Newborns Intraventricular Hemorrhage Causes Cerebral Vasospasm and Associated Neurodisability via Heme-Induced Inflammasome-Mediated Interleukin-1 Production and Nitric Oxide Depletion.	Heme	111-115	interleukin 1 alpha	Homo sapiens	146-159
28868047-3	2017	Pathways linking hemoglobin release from blood clots to vasospasm include heme-induced activation of inflammasomes releasing interleukin-1 (IL-1) that can cause calcium dependent and independent vasospasm.	Heme	74-78	interleukin 1 alpha	Homo sapiens	125-138
28868047-3	2017	Pathways linking hemoglobin release from blood clots to vasospasm include heme-induced activation of inflammasomes releasing interleukin-1 (IL-1) that can cause calcium dependent and independent vasospasm.	Heme	74-78	interleukin 1 alpha	Homo sapiens	140-144
28868047-3	2017	Pathways linking hemoglobin release from blood clots to vasospasm include heme-induced activation of inflammasomes releasing interleukin-1 (IL-1) that can cause calcium dependent and independent vasospasm.	Calcium	161-168	interleukin 1 alpha	Homo sapiens	125-138
28868047-3	2017	Pathways linking hemoglobin release from blood clots to vasospasm include heme-induced activation of inflammasomes releasing interleukin-1 (IL-1) that can cause calcium dependent and independent vasospasm.	Calcium	161-168	interleukin 1 alpha	Homo sapiens	140-144
28868047-6	2017	HYPOTHESIS: In premature newborns, IVH causes cerebral vasospasm and associated neurodisability via heme-induced increased inflammasome-mediated IL-1 production and NO depletion.	Heme	100-104	interleukin 1 alpha	Homo sapiens	145-149
28868047-8	2017	Confirmation of the role of heme in activation of inflammasomes causing IL-1 production and NO binding could be achieved by measuring the effect of heme scavenging interventions on IL-1 levels and levels of NO metabolites.	Heme	28-32	interleukin 1 alpha	Homo sapiens	72-76
28868047-8	2017	Confirmation of the role of heme in activation of inflammasomes causing IL-1 production and NO binding could be achieved by measuring the effect of heme scavenging interventions on IL-1 levels and levels of NO metabolites.	Heme	28-32	interleukin 1 alpha	Homo sapiens	181-185
28485095-7	2017	RT-PCR demonstrated that compared with metformin, myo-inositol downregulated gene expression of interleukin-1 (IL-1) (P=.02) in PBMCs of subjects with PCOS.	Inositol	50-62	interleukin 1 alpha	Homo sapiens	96-116
28801380-5	2017	Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively.	Vitamin D	11-20	interleukin 1 alpha	Homo sapiens	113-117
28605710-5	2017	DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants.	Dextromethorphan	0-3	interleukin 1 alpha	Homo sapiens	97-105
28605710-5	2017	DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants.	Dextromethorphan	0-3	interleukin 1 alpha	Homo sapiens	152-160
27800639-6	2017	RESULTS: Cytokines IL-1alpha and IL-1RA and the antimicrobial peptide hBD-1 showed distinct dynamics, despite substantial inter-individual variation in levels, with an increase following tape stripping and a decrease following histamine iontophoresis.	Histamine	227-236	interleukin 1 alpha	Homo sapiens	19-28
28605710-5	2017	DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants.	5mumu	5-10	interleukin 1 alpha	Homo sapiens	97-105
28605710-5	2017	DEX (5muMu) exposure for 3d significantly increased the expression of NLRP-1, ASC, caspase-1 and IL-1beta in the hippocampal neurons and the release of IL-1beta and IL-18 in the supernatants.	5mumu	5-10	interleukin 1 alpha	Homo sapiens	152-160
28829844-8	2017	Stabilization of DHFR-IkappaBalpha with TMP prevented IL-1alpha-, A2E-, LPS-, and TNFalpha-induced NFkappaB-mediated upregulation and release of the proinflammatory cytokines IL-1beta and IL-6 from ARPE-19 cells (by as much as 93%).	Trimethoprim	40-43	interleukin 1 alpha	Homo sapiens	54-63
28497352-6	2017	Colchicine is still the mainstay of FMF therapy, but IL-1 blockade is also effective if colchicine fails.	Colchicine	88-98	interleukin 1 alpha	Homo sapiens	53-57
28761045-6	2017	Here, we report that inhibiting NLRP3 with the selective inhibitor MCC950, blocked release of IL-1beta and the related cytokine IL-1alpha from primary human monocytes in response to S. typhimurium.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	67-73	interleukin 1 alpha	Homo sapiens	128-137
28773202-6	2017	Furthermore, the bio-composites that included bio-lignin at 0.1% have been able to modulate the expression of pro-inflammatory cytokines (Tumor Necrosis Factor-alpha, IL-1alpha, and IL8), lipopolysaccharide (LPS)-induced, and matrix metalloproteinases (MMPs) and human beta-defensin 2 (HBD-2) expression in HaCat cells, suggesting an anti-inflammatory and immunomodulatory role.	Lignin	50-56	interleukin 1 alpha	Homo sapiens	167-176
28229451-5	2017	RESULTS: Honokiol at 10 mum reduced IL-1alpha production by 3.4 folds (P &lt; 0.05) and at 10 and 20 mum reduced IL-8 by 23.9% and 53.1% (P &lt; 0.001), respectively, in HaCat keratinocytes.	honokiol	9-17	interleukin 1 alpha	Homo sapiens	36-45
28444390-10	2017	SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta.	4-nitrososulfamethoxazole	0-6	interleukin 1 alpha	Homo sapiens	63-72
28444390-10	2017	SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta.	Floxacillin	7-21	interleukin 1 alpha	Homo sapiens	63-72
32264318-5	2017	An enhanced binding was observed for highly functionalized dPG bisphosphonate, sulfate, and phosphate, which additionally showed a higher affinity to IL-1beta treated tissue.	dpg bisphosphonate	59-77	interleukin 1 alpha	Homo sapiens	150-158
32264318-5	2017	An enhanced binding was observed for highly functionalized dPG bisphosphonate, sulfate, and phosphate, which additionally showed a higher affinity to IL-1beta treated tissue.	Sulfates	79-86	interleukin 1 alpha	Homo sapiens	150-158
32264318-5	2017	An enhanced binding was observed for highly functionalized dPG bisphosphonate, sulfate, and phosphate, which additionally showed a higher affinity to IL-1beta treated tissue.	Phosphates	92-101	interleukin 1 alpha	Homo sapiens	150-158
28485095-9	2017	CONCLUSIONS: Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-alpha.	Inositol	29-41	interleukin 1 alpha	Homo sapiens	245-249
28660191-5	2017	For this refractory group, small case series and a recent randomized controlled trial have shown that interleukin-1 inhibition with anakinra is a rapidly acting, highly efficient, steroid-sparing, and safe therapeutic intervention.	Steroids	180-187	interleukin 1 alpha	Homo sapiens	102-115
28532406-0	2017	The addition of vildagliptin to metformin prevents the elevation of interleukin 1ss in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, open-label study.	Vildagliptin	16-28	interleukin 1 alpha	Homo sapiens	68-81
28566936-10	2017	Age older than 45 years combined with 2011 serum phosphate above 1.15 mmol/L had a significant AUC of 0.781, p &lt; 0.0010 interleukin (IL)-1A and IL-28A were significant associates with serum phosphate above 1.1 mmol/L in the MVA.	Phosphates	49-58	interleukin 1 alpha	Homo sapiens	123-142
28566936-10	2017	Age older than 45 years combined with 2011 serum phosphate above 1.15 mmol/L had a significant AUC of 0.781, p &lt; 0.0010 interleukin (IL)-1A and IL-28A were significant associates with serum phosphate above 1.1 mmol/L in the MVA.	Phosphates	193-202	interleukin 1 alpha	Homo sapiens	123-142
28475276-12	2017	Initiation of MTX was associated with reductions in IL-1alpha (p=0.009), IL-1beta (p=0.01), IL-1Ra (p=0.007), and IL-6 (p=0.03) levels; however, reductions in JADAS were only associated with reductions in IL-6 (p=0.009) and TNF-alpha levels (p=0.02).	Methotrexate	14-17	interleukin 1 alpha	Homo sapiens	52-61
28532406-0	2017	The addition of vildagliptin to metformin prevents the elevation of interleukin 1ss in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, open-label study.	Metformin	32-41	interleukin 1 alpha	Homo sapiens	68-81
28532406-11	2017	CONCLUSION: The addition of vildagliptin to metformin treatment in patients with type 2 diabetes and CAD led to a significant suppression of the IL-1ss elevation during follow up.	Vildagliptin	28-40	interleukin 1 alpha	Homo sapiens	145-149
28532406-11	2017	CONCLUSION: The addition of vildagliptin to metformin treatment in patients with type 2 diabetes and CAD led to a significant suppression of the IL-1ss elevation during follow up.	Metformin	44-53	interleukin 1 alpha	Homo sapiens	145-149
28553131-5	2017	DSW and PS were topically applied alone or in combination, and their protection against pollution was assessed by testing the levels of the inflammation markers interleukin 1alpha (IL-1alpha) and prostaglandin E2 (PGE2).	ps	8-10	interleukin 1 alpha	Homo sapiens	181-190
28553131-7	2017	Ozone exposure induced IL-1alpha and PGE2 release.	Ozone	0-5	interleukin 1 alpha	Homo sapiens	23-32
26549801-2	2017	However, the mechanisms regulating IL-1beta expression during Mg2+ dyshomeostasis in AD remain unknown.	magnesium ion	62-66	interleukin 1 alpha	Homo sapiens	35-43
28656057-2	2017	We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity for cyclooxygenase 2 (COX-2) over COX-1, reduce the concentration of inflammatory cytokines (IL-1 and TNFalpha), and induce apoptosis in fibroblast-like synoviocytes while maintaining biocompatibility with healthy chondrocytes.	Ketoprofen	18-28	interleukin 1 alpha	Homo sapiens	175-192
26549801-3	2017	We herein studied the mechanism of IL-1beta reduction using a recently developed compound, magnesium-L-threonate (MgT).	BIS[(2R,3S)-2,3,4-Trihydroxybutanoato-alphao,alphao']magnesium	91-112	interleukin 1 alpha	Homo sapiens	35-43
26549801-3	2017	We herein studied the mechanism of IL-1beta reduction using a recently developed compound, magnesium-L-threonate (MgT).	mgt	114-117	interleukin 1 alpha	Homo sapiens	35-43
28554965-4	2017	In addition, inhibition of interleukin-1 (IL-1) signaling by anakinra, a recombinant human IL-1Ra, or a murinized anti-IL-1beta antibody attenuates the inflammatory and ultimate cell death response elicited by FetA alone or combined with palmitic acid.	Palmitic Acid	238-251	interleukin 1 alpha	Homo sapiens	27-46
27009845-4	2017	RESULTS: Significantly greater expression of IL-1alpha in the epithelium was noted in RC, KCOT and SA (P = 0.01), whilst IL-10 and TNF-alpha was in the epithelium of RC, DC and KCOT (P &lt; 0.01).	sa	99-101	interleukin 1 alpha	Homo sapiens	45-54
27403856-6	2017	Moreover, we also found that stromal-derived PGE2, acting as a stimulator of IL-1 epithelial expression was one of the factors that promote the acquisition of motile properties by epithelial cells and the maintenance of a COX-2/PGE2-dependent inflammatory condition.	Dinoprostone	45-49	interleukin 1 alpha	Homo sapiens	77-81
27403856-6	2017	Moreover, we also found that stromal-derived PGE2, acting as a stimulator of IL-1 epithelial expression was one of the factors that promote the acquisition of motile properties by epithelial cells and the maintenance of a COX-2/PGE2-dependent inflammatory condition.	Dinoprostone	228-232	interleukin 1 alpha	Homo sapiens	77-81
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Chenodeoxycholic Acid	59-63	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Lithocholic Acid	82-85	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	cdca+-pic	86-95	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Reactive Oxygen Species	120-143	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Reactive Oxygen Species	145-148	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Lithocholic Acid	173-176	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Reactive Oxygen Species	197-200	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Chenodeoxycholic Acid	86-90	interleukin 1 alpha	Homo sapiens	11-14
28554966-10	2017	TNFalpha + IL1ss increased IFNgamma, which was enhanced by CDCA and attenuated by LCA CDCA+-PiC increased production of reactive oxygen species (ROS) that was attenuated by LCA Finally, scavenging ROS attenuated CDCA"s leak, but not pore actions, and LCA enhanced this effect.	Lithocholic Acid	173-176	interleukin 1 alpha	Homo sapiens	11-14
28299617-6	2017	In particular, methyl caffeate down-regulated SASP factors such as IL-1alpha, IL-1beta, IL-6, IL-8, GM-CSF, CXCL1, MCP-2, and MMP-3.	methyl caffeate	15-30	interleukin 1 alpha	Homo sapiens	67-76
28068541-1	2017	In this paper, bismuth oxybromide (BiOBr) nanosquares photocatalysts were synthesized via a facile hydrothermal method with the double regulation of the ionic liquid (IL) 1-hexadecyl-3-methylimidazolium bromide and ammonium bismuth citrate (BCA).	bismuth oxybromide	15-33	interleukin 1 alpha	Homo sapiens	153-172
28068541-1	2017	In this paper, bismuth oxybromide (BiOBr) nanosquares photocatalysts were synthesized via a facile hydrothermal method with the double regulation of the ionic liquid (IL) 1-hexadecyl-3-methylimidazolium bromide and ammonium bismuth citrate (BCA).	bismuth oxybromide	35-40	interleukin 1 alpha	Homo sapiens	153-172
28068541-1	2017	In this paper, bismuth oxybromide (BiOBr) nanosquares photocatalysts were synthesized via a facile hydrothermal method with the double regulation of the ionic liquid (IL) 1-hexadecyl-3-methylimidazolium bromide and ammonium bismuth citrate (BCA).	hexadecyl-3-methylimidazolium bromide	173-210	interleukin 1 alpha	Homo sapiens	153-172
28078769-12	2017	We established an in vitro model wherein steroids inhibit the IL-1alpha-induced IL-8 production, while azithromycin was ineffective.	Steroids	41-49	interleukin 1 alpha	Homo sapiens	62-71
28685525-7	2017	IL-37 is a family member cytokine which binds IL-18 receptor alpha chain and inhibits inflammatory mediators including TNF, IL-1, IL-6, IL-33 and nitric oxide (NO).	Nitric Oxide	146-158	interleukin 1 alpha	Homo sapiens	46-50
28078769-2	2017	Persistently elevated BAL-neutrophilia is observed in some patients despite treatment with azithromycin, which may be induced by IL-1alpha.	Azithromycin	91-103	interleukin 1 alpha	Homo sapiens	129-138
28078769-8	2017	IL-1alpha induced IL-8 in bronchial epithelial cells, which was dose-dependently inhibited by dexamethasone but not by azithromycin.	Dexamethasone	94-107	interleukin 1 alpha	Homo sapiens	0-9
28011320-7	2017	In autophagy-deficient macrophages, mitochondrial ROS mediated inflammation- and fibrosis-promoting effects by increasing IL1alpha/beta production via enhancing NF-kappaB-associated pathways.	ros	50-53	interleukin 1 alpha	Homo sapiens	122-130
28011320-9	2017	In conclusion, autophagy-deficient Kupffer cells promote liver fibrosis, inflammation and, finally, hepatocarcinogenesis during the preneoplastic stage by enhancing mitochondrial ROS- NF-kappaB-IL1alpha/beta pathways.	ros	179-182	interleukin 1 alpha	Homo sapiens	194-202
27328763-8	2017	Sixteen patients with colchicine resistance had no attacks under anti-IL-1 treatment, and 4 had decreased frequency and duration of attacks.	Colchicine	22-32	interleukin 1 alpha	Homo sapiens	70-74
27328763-13	2017	CONCLUSION: Anti-IL-1 agents are rational treatment modalities in patients resistant or intolerant to colchicine.	Colchicine	102-112	interleukin 1 alpha	Homo sapiens	17-21
28006746-3	2017	Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitrico oxide (NO).	anethole	0-14	interleukin 1 alpha	Homo sapiens	220-224
32185252-1	2017	Objectives: To determine the impact of celecoxib and etoricoxib therapy on serum and synovial fluid levels of IL-1beta, IL-6, TNF-alpha, sTNFR1, sTNFR2 and IL-1Ra in patients with inflammatory arthritis.	Etoricoxib	53-63	interleukin 1 alpha	Homo sapiens	110-118
32185252-9	2017	Correlating the study drugs penetration index with the change of cytokines and their receptors levels, positive correlation was found with the reduction of synovial fluid IL-1beta for the celecoxib (p=0.032) and with the increase of synovial fluid sTNFR1 for the etoricoxib group (p=0.028).	Celecoxib	188-197	interleukin 1 alpha	Homo sapiens	171-179
32185252-9	2017	Correlating the study drugs penetration index with the change of cytokines and their receptors levels, positive correlation was found with the reduction of synovial fluid IL-1beta for the celecoxib (p=0.032) and with the increase of synovial fluid sTNFR1 for the etoricoxib group (p=0.028).	Etoricoxib	263-273	interleukin 1 alpha	Homo sapiens	171-179
28323859-0	2017	Diacerein inhibits the pro-atherogenic &amp; pro-inflammatory effects of IL-1 on human keratinocytes &amp; endothelial cells.	diacerein	0-9	interleukin 1 alpha	Homo sapiens	73-77
28323859-0	2017	Diacerein inhibits the pro-atherogenic &amp; pro-inflammatory effects of IL-1 on human keratinocytes &amp; endothelial cells.	Adenosine Monophosphate	40-43	interleukin 1 alpha	Homo sapiens	73-77
28323859-0	2017	Diacerein inhibits the pro-atherogenic &amp; pro-inflammatory effects of IL-1 on human keratinocytes &amp; endothelial cells.	Adenosine Monophosphate	102-105	interleukin 1 alpha	Homo sapiens	73-77
28323859-7	2017	The results support a novel idea that diacerein acts as an inhibitor of the pro-atherogenic and pro-inflammatory effects of IL-1.	diacerein	38-47	interleukin 1 alpha	Homo sapiens	124-128
28323859-8	2017	Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis.	diacerein	0-9	interleukin 1 alpha	Homo sapiens	56-60
28323859-8	2017	Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis.	diacerein	0-9	interleukin 1 alpha	Homo sapiens	114-118
28126596-3	2017	The results of cellular experiments confirmed that the gene expression of most inflammatory factors (IL-1, IL-6 and MCP-1) and growth factors (VEGF, PDGF and EGF) by macrophages were up-regulated to varying degrees by BCP ceramic and its degradation products.	hydroxyapatite-beta tricalcium phosphate	218-221	interleukin 1 alpha	Homo sapiens	101-105
28302131-11	2017	Interleukin 1-targeting drugs represented the only alternative treatments in addition to daily colchicine.	Colchicine	95-105	interleukin 1 alpha	Homo sapiens	0-13
28293317-1	2017	AIM: The purpose of this study is to see the effect of Dexketoprofen on TNF-alpha, IL-1, and IL-6 serum levels in Chronic Tension-Type Headache (CTTH) patients and its correlation with pain severity.	dexketoprofen trometamol	55-68	interleukin 1 alpha	Homo sapiens	83-87
28278187-6	2017	Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue.	Resveratrol	15-26	interleukin 1 alpha	Homo sapiens	114-123
27417275-13	2017	CONCLUSIONS: Intravitreal dexamethasone treatment resulted in alterations in the concentrations of pro-inflammatory cytokines MCP-1 and IL17-E in patients with BRVO and MCP-1 and IL1-alpha in patients with CRVO.	Dexamethasone	26-39	interleukin 1 alpha	Homo sapiens	179-188
26984936-4	2017	Perinatal H-I induced selective neuronal death, ventriculomegaly, elevated CNS levels of IL-6 and IL-1alpha, astrogliosis, and fewer proliferating oligodendrocyte progenitors.	His-Ile	10-13	interleukin 1 alpha	Homo sapiens	98-107
27411036-8	2017	We found that static coefficient of friction (COF) significantly decreased to 0.14 +- 0.065 from 0.21 +- 0.059 (p = 0.014) in IL-1alpha stimulated explants lubricated with rhPRG4, as compared to PBS.	Lead	195-198	interleukin 1 alpha	Homo sapiens	126-135
27411036-10	2017	Explants stimulated with IL-1alpha displayed no increase in PRG4 expression upon lubrication with rhPRG4, but with PBS as the lubricant, IL-1alpha stimulation significantly increased PRG4 expression compared to the control condition from 30.8 +- 19 copies to 401 +- 340 copies (p = 0.015).	Lead	115-118	interleukin 1 alpha	Homo sapiens	137-146
27655254-7	2017	LPS-induced upregulation of IL-1alpha/beta, IL-6 and TNF-alpha was also diminished by the TGR5-ligands allopregnanolone and taurolithocholic acid in mono-cultured microglia.	Pregnanolone	103-119	interleukin 1 alpha	Homo sapiens	28-37
27655254-7	2017	LPS-induced upregulation of IL-1alpha/beta, IL-6 and TNF-alpha was also diminished by the TGR5-ligands allopregnanolone and taurolithocholic acid in mono-cultured microglia.	Taurolithocholic Acid	124-145	interleukin 1 alpha	Homo sapiens	28-37
28223797-11	2017	An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide (NO), Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) (P&lt;0.01) and an increase in superoxide dismutase activity (P&lt;0.05) compared to the ADG coarse powder.	adg-ns	94-100	interleukin 1 alpha	Homo sapiens	230-243
28223797-11	2017	An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide (NO), Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) (P&lt;0.01) and an increase in superoxide dismutase activity (P&lt;0.05) compared to the ADG coarse powder.	adg-ns	94-100	interleukin 1 alpha	Homo sapiens	245-249
28223797-11	2017	An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide (NO), Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) (P&lt;0.01) and an increase in superoxide dismutase activity (P&lt;0.05) compared to the ADG coarse powder.	andrographolide	94-97	interleukin 1 alpha	Homo sapiens	230-243
28223797-11	2017	An evaluation of the anti-inflammatory effect on Carr-induced paw edema demonstrated that the ADG-NS were more effective in reducing the rate of paw swelling, producing a greater increase in the serum levels of nitric oxide (NO), Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) (P&lt;0.01) and an increase in superoxide dismutase activity (P&lt;0.05) compared to the ADG coarse powder.	andrographolide	94-97	interleukin 1 alpha	Homo sapiens	245-249
28553653-6	2017	Our study revealed several unexpected correlations which are indicative of a much more complex relationship between glucose and lipid factors (namely, glycosylated haemoglobin Hb1Ac, the presence of one but not multiple chronic diabetic complications, and atherogenic indexes) and proinflammatory cytokines (IL-1alpha and TNF-alpha).	Glucose	116-123	interleukin 1 alpha	Homo sapiens	308-317
28046113-10	2017	Treatment with butylated hydroxyanisole, a free radical scavenger, attenuated the ozone-induced increases in IL-6 expression in IL-1alpha-pretreated conjunctival epithelial cells.	Butylated Hydroxyanisole	15-39	interleukin 1 alpha	Homo sapiens	128-137
28046113-11	2017	Therefore, we conclude that exposure to ozone exacerbates the detrimental effects on the integrity of the ocular surface caused by conjunctival allergic reactions, and further increases the inflammatory response in IL-1alpha-pretreated conjunctival epithelial cells.	Ozone	40-45	interleukin 1 alpha	Homo sapiens	215-224
28966239-2	2017	We previously reported that eudesmane-type sesquiterpene lactones inhibited multiple steps in the canonical NF-kappaB signaling pathway induced by tumor necrosis factor-alpha and interleukin-1alpha.	sesquiterpene lactones	43-65	interleukin 1 alpha	Homo sapiens	179-197
27709431-6	2017	In addition, endosulfan promoted the increases of ROS, IL-1alpha, and IL-33 levels while antioxidant N-acetyl-L-cysteine (NAC) effectively attenuated the cytotoxicity from endosulfan.	Endosulfan	13-23	interleukin 1 alpha	Homo sapiens	55-64
28163961-7	2017	RESULTS: After 60 days, both types of boron significantly improve the clinical scores, in association with significant decrease in the serum levels of ESR, hsCRP, IL-1alpha, IL-6, and TNF-alpha with remarkable superiority for calcium fructoborate (CFB) over sodium tetraborate (NTB), compared to baseline and placebo-treated group.	Boron	38-43	interleukin 1 alpha	Homo sapiens	163-172
29430085-6	2017	This review discusses the available evidence regarding the potential antiatherosclerotic effects of methotrexate through the inhibition of TNF-alpha, IL-1, and IL-6 and provides suggestions for future experimental and human studies addressing this issue.	Methotrexate	100-112	interleukin 1 alpha	Homo sapiens	150-154
28140833-8	2017	Exposure of human epithelial cells to TiO2-NP enhanced interleukin (IL)-1alpha synthesis, as well as nerve growth factor (NGF) gene expression and protein levels, specifically the precursor form (proNGF).	tio2-np	38-45	interleukin 1 alpha	Homo sapiens	55-78
27779898-7	2016	The active form of VD is 1,25(OH)2D3 that produces biological effects via the nuclear hormone receptor named VD receptor (VDR), which may interfere with the immune cells and macrophages leading to the suppression of the inflammatory process by decreasing the release of TNF-alpha, IL-1, IL-6, and IL-8, IL-12, and IL-23.	Calcitriol	25-36	interleukin 1 alpha	Homo sapiens	281-285
27150261-3	2016	The aim of these studies was to evaluate the pharmacokinetics of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) capable of simultaneously binding IL-1alpha and IL-1beta, in healthy subjects and patients with osteoarthritis of the knee.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	65-68	interleukin 1 alpha	Homo sapiens	155-164
27588816-8	2016	However, when combining IL-1ss, IL-6 and G-CSF in the patients with CD, the cytokine levels were significantly lower in the AndoSanTM - versus the placebo group, visit 3.	andosantm	124-133	interleukin 1 alpha	Homo sapiens	24-28
26840621-9	2016	After co-treatment with the DNMT inhibitor 5-Aza-2"-deoxycytidine and DNMT siRNA, methylation of NF2 induced by IL-1beta was attenuated and merlin expression was restored.	Decitabine	43-65	interleukin 1 alpha	Homo sapiens	112-120
27829611-6	2016	HaCaT keratinocytes treated with SLS had increased levels of intracellular ROS and IL-1alpha secretion.	Sodium Dodecyl Sulfate	33-36	interleukin 1 alpha	Homo sapiens	83-92
27829611-10	2016	In addition, IL-1alpha also stimulated ROS generation by HaCaT keratinocytes.	Reactive Oxygen Species	39-42	interleukin 1 alpha	Homo sapiens	13-22
27829611-14	2016	IL-1alpha also stimulates ROS generation by HaCaT keratinocytes.	Reactive Oxygen Species	26-29	interleukin 1 alpha	Homo sapiens	0-9
27549123-12	2016	IL1alpha, TNFalpha, and CXCL10, together with VEGF neutralization, contribute to Ipi-Bev-induced melanoma immune recognition.	ipi-bev	81-88	interleukin 1 alpha	Homo sapiens	0-8
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	interleukin 1 alpha	Homo sapiens	0-9
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric acetate	108-116	interleukin 1 alpha	Homo sapiens	0-9
27823983-7	2016	Furthermore, RNA-Seq analysis revealed the overexpression of cisplatin resistance associated genes such as SLC7A11, TLE4, and IL1A in BLCAb001.	Cisplatin	61-70	interleukin 1 alpha	Homo sapiens	126-130
26969796-10	2016	In human monocytes, prostaglandin E2 (PGE2 ) stimulates MMP production, and inflammatory mediators such as tumour necrosis factor alpha, interleukin-1 and Toll-like receptor ligands can act either through or independently of PGE2 .	Dinoprostone	20-36	interleukin 1 alpha	Homo sapiens	137-173
26969796-10	2016	In human monocytes, prostaglandin E2 (PGE2 ) stimulates MMP production, and inflammatory mediators such as tumour necrosis factor alpha, interleukin-1 and Toll-like receptor ligands can act either through or independently of PGE2 .	Dinoprostone	225-229	interleukin 1 alpha	Homo sapiens	137-173
27914450-9	2016	The elevation in the content of IL-1alpha in nuclei was accompanied by increased acetylation of nuclear proteins, which has been reduced to control values after exposure to protective agents (Trolox, mitochondria-targeted antioxidant SkQR1 or LiCl).	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	192-198	interleukin 1 alpha	Homo sapiens	32-41
27882140-8	2016	Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-alpha in the HES group compared with the control group.	Hydroxyethyl Starch Derivatives	179-182	interleukin 1 alpha	Homo sapiens	153-157
27882140-11	2016	Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient"s immune status as well as renal function during the early phase of SAP.	Hydroxyethyl Starch Derivatives	6-9	interleukin 1 alpha	Homo sapiens	51-55
27357856-7	2016	Negative correlations were observed between serum 25OHD and TNFalpha, IL-1beta or IL-6 levels in healthy subjects or MCI patients, but these same correlations were positive in LOAD patients.	25ohd	50-55	interleukin 1 alpha	Homo sapiens	70-78
27309886-0	2016	Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.	Lidocaine	22-31	interleukin 1 alpha	Homo sapiens	129-133
26502273-5	2016	Under in vitro conditions graphene and GO cause an increased production of pro-inflammatory cytokines, mainly IL-1, IL-6, IL-10 and TNF-alpha, as a result of the activation of Toll-like receptors in macrophages.	Graphite	26-34	interleukin 1 alpha	Homo sapiens	110-114
27260851-7	2016	Besides, DHEA inhibited the anchorage-independent growth on agar and decreased the size of spheroids, and also reduced the secretion of IL-1alpha, IL-6, IL-8, and TNF-alpha in all cell lines.	Dehydroepiandrosterone	9-13	interleukin 1 alpha	Homo sapiens	136-145
27240953-4	2016	Inhibition of the interleukin 1alpha (IL-1alpha)-induced aggrecan degradation by beta-cryptoxanthin was also observed with porcine articular cartilage explants in culture.	Beta-Cryptoxanthin	81-99	interleukin 1 alpha	Homo sapiens	18-36
27240953-4	2016	Inhibition of the interleukin 1alpha (IL-1alpha)-induced aggrecan degradation by beta-cryptoxanthin was also observed with porcine articular cartilage explants in culture.	Beta-Cryptoxanthin	81-99	interleukin 1 alpha	Homo sapiens	38-47
27240953-5	2016	beta-Cryptoxanthin (1-10 muM) dose-dependently down-regulated the IL-1alpha-induced gene expression of aggrecanase 1 (ADAMTS-4) and aggrecanase 2 (ADAMTS-5) in cultured human chondrocytes.	Beta-Cryptoxanthin	0-18	interleukin 1 alpha	Homo sapiens	66-75
27072068-5	2016	Experiment 1 tested whether hippocampal IL-1 is also required for the acquisition of heroin conditioned immunosuppression, while Experiment 2 tested whether hippocampal IL-1 is required for the expression of unconditioned heroin immunosuppression.	Heroin	85-91	interleukin 1 alpha	Homo sapiens	40-44
27072068-8	2016	Thus, IL-1 signaling is not a critical component of the response to heroin but rather may play a role in the formation of the association between heroin and the context.	Heroin	146-152	interleukin 1 alpha	Homo sapiens	6-10
27313060-1	2016	The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events.	Sphingolipids	14-26	interleukin 1 alpha	Homo sapiens	166-170
27313060-1	2016	The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events.	Ceramides	39-47	interleukin 1 alpha	Homo sapiens	166-170
27313060-1	2016	The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events.	Ceramides	133-141	interleukin 1 alpha	Homo sapiens	166-170
27313060-2	2016	Although much has been learned about ceramide generation by activation of sphingomyelinases in response to IL-1, the contribution of the de novo pathway is not completely understood.	Ceramides	37-45	interleukin 1 alpha	Homo sapiens	107-111
27313060-5	2016	IL-1 and the IL-6 family cytokine, oncostatin M, increased dihydroceramide and ceramide levels in HepG2 cells and concomitantly decreased ORMDL proteins.	dihydroceramide	59-74	interleukin 1 alpha	Homo sapiens	0-4
27313060-5	2016	IL-1 and the IL-6 family cytokine, oncostatin M, increased dihydroceramide and ceramide levels in HepG2 cells and concomitantly decreased ORMDL proteins.	Ceramides	66-74	interleukin 1 alpha	Homo sapiens	0-4
27313060-7	2016	Together, our results suggest that ORMDLs may be involved in regulation of ceramides during IL-1-mediated sterile inflammation.	Ceramides	75-84	interleukin 1 alpha	Homo sapiens	92-96
27166719-9	2016	Differences in IL-1beta levels could be because of glia population (i.e. microglia and astrocytes), mitogen-activated protein kinase and nuclear factor kappa light-chain-enhancer of activated B cells signaling pathways, and several mediators (including cyclooxygenase, neurotrophic factors, reactive oxygen species, caspases, heme oxygenase-1, and matrix metalloproteinases).	Oxygen	258-264	interleukin 1 alpha	Homo sapiens	15-23
25976168-5	2016	We also found that the inflammatory cytokines IL-1, IL-6, and TNF-alpha were induced more strongly by titanium particles (TiMPs) group than by either MgMPs or control.	Titanium	102-110	interleukin 1 alpha	Homo sapiens	46-50
27200471-0	2016	Inhibition of TNF-alpha, IL-1alpha, and IL-1beta by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.	vitamin MK 7	108-121	interleukin 1 alpha	Homo sapiens	25-34
27200471-8	2016	MK-7 is able to modulate immune and inflammatory reactions in the dose-response inhibition of TNF-alpha, IL-1alpha, and IL-1beta gene expression and protein production by the healthy hMDMs in vitro.	vitamin MK 7	0-4	interleukin 1 alpha	Homo sapiens	105-114
27376271-8	2016	Furthermore, AL7 also modulated the expression of COX-2, IL-1beta and TNF-alpha in these cell lines, suggesting anti-inflammatory activity.	AL7099A	13-16	interleukin 1 alpha	Homo sapiens	57-65
27667443-4	2016	Upon treatment with acetate SCFA or FFAR2- and FFAR3-specific synthetic agonists, human monocytes displayed elevated p38 phosphorylation and attenuated C5, CCL1, CCL2, GM-CSF, IL-1alpha, IL-1beta and ICAM-1 inflammatory cytokine expression.	Acetates	20-27	interleukin 1 alpha	Homo sapiens	176-185
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	interleukin 1 alpha	Homo sapiens	135-144
27273653-8	2016	Results from this study suggest that ROS stimulated by ALA-PDT lead to inhibition of FGFR2b pathway in PKC downstream to cause reduction of IL1alpha expression, and eventually, keratinocytes differentiation and proliferation.	Reactive Oxygen Species	37-40	interleukin 1 alpha	Homo sapiens	140-148
27273653-8	2016	Results from this study suggest that ROS stimulated by ALA-PDT lead to inhibition of FGFR2b pathway in PKC downstream to cause reduction of IL1alpha expression, and eventually, keratinocytes differentiation and proliferation.	Alanine	55-58	interleukin 1 alpha	Homo sapiens	140-148
27274232-9	2016	A 1.5- to 1.8-fold increase in interleukin-1alpha expression was induced by ME-T compared to the other formulations, but this effect was less pronounced (5.8-fold) than that mediated by the moderate irritant Triton.	me-t	76-80	interleukin 1 alpha	Homo sapiens	31-49
26780754-6	2016	RESULTS: Although PEMF treatment did not completely inhibit the effects of IL-1alpha, PEMF treatment lessened the IL-1alpha-induced upregulation of genes expressed in degenerated IVDs.	pemf	86-90	interleukin 1 alpha	Homo sapiens	114-123
26780754-7	2016	Consistent with our previous results, after 4 days, PEMF tended to reduce IL-1alpha-associated gene expression of IL-6 (25%, p=.07) in NP cells and MMP13 (26%, p=.10) in AF cells.	pemf	52-56	interleukin 1 alpha	Homo sapiens	74-83
26780754-8	2016	Additionally, PEMF treatment significantly diminished IL-1alpha-induced gene expression of IL-17A (33%, p=.01) and MMP2 (24%, p=.006) in NP cells and NFkappaB (11%, p=.04) in AF cells.	pemf	14-18	interleukin 1 alpha	Homo sapiens	54-63
26100656-15	2016	Zinc oxide cement caused a significant up-regulation in IL-1alpha and TNF-alpha (P &lt; 0.05).	Zinc Oxide	0-10	interleukin 1 alpha	Homo sapiens	56-65
26100656-16	2016	No significant differences amongst MTA, Biodentine and the negative control group were observed for TNF-alpha (P &gt; 0.05); however, both MTA and Biodentine were associated with overproduction of IL-1alpha when compared to the control group (P &lt; 0.05).	tricalcium silicate	147-157	interleukin 1 alpha	Homo sapiens	197-206
26823290-8	2016	After 24 h pre-treatment with 5 muM laquinimod, manHD monocytes released lower levels of IL-1beta, IL-5, IL-8, IL-10, IL-13 and TNFalpha in response to stimulation.	5 mum laquinimod	30-46	interleukin 1 alpha	Homo sapiens	89-97
26879129-4	2016	Compared with controls, the levels of connexin 43 and connexin 43 (Ser 368) increased ~30- and 20-fold, respectively, at 24 h after IL1A treatment.	Serine	67-70	interleukin 1 alpha	Homo sapiens	132-136
26879129-10	2016	In summary, IL1A regulates GJC in Sertoli cells, which is critical for BTB restructuring.	btb	71-74	interleukin 1 alpha	Homo sapiens	12-16
26695178-4	2016	This analysis showed an association between BD and the TT + TC genotypes of the IL-1A-889 C/T polymorphism in the entire study population [odds ratio (OR) = 0.623, 95 % CI = 0.395-0.981, p = 0.045), and a trend toward an association in a Turkish population (OR = 0.578, 95 % CI = 0.331-1.010, p = 0.054).	tt + tc	55-62	interleukin 1 alpha	Homo sapiens	80-85
26994310-3	2016	The purpose of this article is to describe a novel, on-site, point of service process (Arthrokinex ) to induce Interleukin 1 Receptor Antagonist Protein (IL-1-Ra or IRAP) from whole blood aimed at inhibiting the destructive intra-articular effects of IL-1.	arthrokinex	87-98	interleukin 1 alpha	Homo sapiens	154-158
25649126-2	2016	Calprotectin (S100A8/S100A9) is one of these AMPs in oral epithelial cells, the expression of which is up-regulated by interleukin-1alpha (IL-1alpha).	Adenylyl sulfate	45-49	interleukin 1 alpha	Homo sapiens	119-137
25649126-2	2016	Calprotectin (S100A8/S100A9) is one of these AMPs in oral epithelial cells, the expression of which is up-regulated by interleukin-1alpha (IL-1alpha).	Adenylyl sulfate	45-49	interleukin 1 alpha	Homo sapiens	139-148
26908041-8	2016	Following IT, antigen-stimulated whole blood culture production of IL-1alpha was higher in L-CHO than H-CHO (0.70 (95 % CI 0.52-0.95) pg/ml versus 0.33 (0.24-0.45) pg/ml, P &lt; 0.01), as was production of IL-1beta (9.3 (95 % CI 7-10.4) pg/ml versus 6.0 (5.0-7.8) pg/ml, P &lt; 0.05).	l-cho	91-96	interleukin 1 alpha	Homo sapiens	67-76
26908041-8	2016	Following IT, antigen-stimulated whole blood culture production of IL-1alpha was higher in L-CHO than H-CHO (0.70 (95 % CI 0.52-0.95) pg/ml versus 0.33 (0.24-0.45) pg/ml, P &lt; 0.01), as was production of IL-1beta (9.3 (95 % CI 7-10.4) pg/ml versus 6.0 (5.0-7.8) pg/ml, P &lt; 0.05).	h-cho	102-107	interleukin 1 alpha	Homo sapiens	67-76
26908918-9	2016	Moreover, PGF2alpha elevated gene expression of biglycan, matrix metalloproteinase 9, transforming growth factor beta3, and interleukin 1alpha in the endometrium.	Dinoprost	10-19	interleukin 1 alpha	Homo sapiens	124-142
26840091-7	2016	This study shows that a monoclonal anti-TLR4 antibody inhibited cobalt-mediated increases in pro-inflammatory IL8, CCL20 and IL1A expression, as well as IL-8 secretion.	Cobalt	64-70	interleukin 1 alpha	Homo sapiens	125-129
26937653-10	2016	In addition, blood IL-1beta levels were significantly greater in AD patients carrying both the APOEepsilon4 allele and the IL-1beta-31TT genotype than in those carrying the APOEepsilon4 allele and the -31 TC or CC genotype.	Technetium	205-207	interleukin 1 alpha	Homo sapiens	19-27
26794530-7	2016	Moreover, GSK461364 exerted a cytotoxic effect by inducing apoptosis in OS, and induced cellular senescence in OS cell lines, as indicated by an increased senescence-associated beta-galactosidase activity and enhanced DcR2 and interleukin-1alpha expression.	GSK 461364	10-19	interleukin 1 alpha	Homo sapiens	227-245
27110096-8	2016	Anti-IL-1 therapy seems to be a safe and effective alternative for patients with FMF who do not respond to or cannot tolerate colchicine.	Colchicine	126-136	interleukin 1 alpha	Homo sapiens	5-9
26956216-0	2016	Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1alpha.	Dexamethasone	0-13	interleukin 1 alpha	Homo sapiens	95-113
26956216-3	2016	This study tested the hypothesis that the incorporation of poly(lactic-co-glycolic acid) (PLGA) (75:25) microspheres that release dexamethasone from within chondrocyte-seeded agarose hydrogel constructs would promote development of constructs with functional properties and protect constructs from the deleterious effects of interleukin-1alpha (IL-1alpha).	Polylactic Acid-Polyglycolic Acid Copolymer	59-88	interleukin 1 alpha	Homo sapiens	325-343
26956216-3	2016	This study tested the hypothesis that the incorporation of poly(lactic-co-glycolic acid) (PLGA) (75:25) microspheres that release dexamethasone from within chondrocyte-seeded agarose hydrogel constructs would promote development of constructs with functional properties and protect constructs from the deleterious effects of interleukin-1alpha (IL-1alpha).	Polylactic Acid-Polyglycolic Acid Copolymer	59-88	interleukin 1 alpha	Homo sapiens	345-354
26956216-3	2016	This study tested the hypothesis that the incorporation of poly(lactic-co-glycolic acid) (PLGA) (75:25) microspheres that release dexamethasone from within chondrocyte-seeded agarose hydrogel constructs would promote development of constructs with functional properties and protect constructs from the deleterious effects of interleukin-1alpha (IL-1alpha).	Dexamethasone	130-143	interleukin 1 alpha	Homo sapiens	325-343
26956216-3	2016	This study tested the hypothesis that the incorporation of poly(lactic-co-glycolic acid) (PLGA) (75:25) microspheres that release dexamethasone from within chondrocyte-seeded agarose hydrogel constructs would promote development of constructs with functional properties and protect constructs from the deleterious effects of interleukin-1alpha (IL-1alpha).	Dexamethasone	130-143	interleukin 1 alpha	Homo sapiens	345-354
32263018-3	2016	This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose.	Triamcinolone	62-75	interleukin 1 alpha	Homo sapiens	312-320
32263018-3	2016	This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose.	Polyethylene Glycols	80-99	interleukin 1 alpha	Homo sapiens	312-320
32263018-3	2016	This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose.	Polyethylene Glycols	101-104	interleukin 1 alpha	Homo sapiens	312-320
32263018-3	2016	This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose.	Carbon	130-136	interleukin 1 alpha	Homo sapiens	312-320
26514426-5	2016	MEK inhibitor U0126, NF-kappaB inhibitor BAY-11-7085, and siRNA targeting p65/RelA significantly inhibited IL-1alpha or IL-beta-induced ADAM17 expression.	U 0126	14-19	interleukin 1 alpha	Homo sapiens	107-116
26514426-6	2016	Cilostazol significantly inhibited IL-1alpha or IL-1beta-induced extracellular signal-regulated kinase (ERK) phosphorylation and ADAM17 expression.	Cilostazol	0-10	interleukin 1 alpha	Homo sapiens	35-44
26514426-9	2016	Moreover, the inhibitory effects of cilostazol on IL-1-induced ADAM17 expression may be independent of the cAMP signaling pathway in VSMC.	Cilostazol	36-46	interleukin 1 alpha	Homo sapiens	50-54
26853432-7	2016	The PD inducer rotenone could activate neuronal inflammasomes and promote the maturation and secretion of the cleaved IL-1beta and IL-18 in a dose- and time-dependent manner.	Rotenone	15-23	interleukin 1 alpha	Homo sapiens	118-126
26862462-6	2016	All ADSCs evaluated also responded to dHACM treatment with altered expression of immunomodulatory genes, including interleukins (IL)-1alpha, IL-1beta, and IL-1RA.	dhacm	38-43	interleukin 1 alpha	Homo sapiens	115-139
26732432-11	2016	In U373 cells and human primary astrocytes, the selective CK2 inhibitor CX-4945 shows a dose-dependent reduction of the IL-1beta or TNF-alpha induced MCP-1 and IL-6 secretion.	silmitasertib	72-79	interleukin 1 alpha	Homo sapiens	120-128
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	interleukin 1 alpha	Homo sapiens	270-278
26827637-6	2016	The anti-inflammatory effect of sulforaphane on Abeta1-42-induced IL-1beta production was diminished by small interfering RNA-mediated knockdown of Nrf2 or HO-1.	sulforaphane	32-44	interleukin 1 alpha	Homo sapiens	66-74
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	interleukin 1 alpha	Homo sapiens	254-262
26708087-5	2016	BSCB permeability increases transiently only after injury that induces mechanical hyperalgesia, which correlates with serum concentrations of pro-inflammatory cytokines, IL-7, IL-12, IL-1alpha and TNF-alpha.	bscb	0-4	interleukin 1 alpha	Homo sapiens	183-192
25213327-10	2016	Anti-IL-1 therapies can be successfully used in colchicine-resistant FMF patients and patients with amyloidosis during childhood and adolescent period without major side effects.	Colchicine	48-58	interleukin 1 alpha	Homo sapiens	5-9
26577567-3	2016	Furthermore, iron sequestration by monocytes/macrophages is regulated by pro-inflammatory cytokines including interleukin-1, highlighting the importance of these cells in the crosstalk between inflammation and iron homeostasis.	Iron	13-17	interleukin 1 alpha	Homo sapiens	110-123
26577567-3	2016	Furthermore, iron sequestration by monocytes/macrophages is regulated by pro-inflammatory cytokines including interleukin-1, highlighting the importance of these cells in the crosstalk between inflammation and iron homeostasis.	Iron	210-214	interleukin 1 alpha	Homo sapiens	110-123
26878794-7	2016	PCB 126 exposure increased the expression of vascular inflammatory mediators, including interleukin (IL)-6, C-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and IL-1alpha/beta, which were prevented by pretreatment with EGCG.	Polychlorinated Biphenyls	0-3	interleukin 1 alpha	Homo sapiens	201-210
26646778-8	2016	Our results also indicated that expressions of interleukin (IL)-1alpha, IL-1beta, IL-6, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in gut tissue were downregulated by treatments of TFDG, and immunity cytokine secretions in the serum were regulated after oral administration of TFDG.	tfdg	229-233	interleukin 1 alpha	Homo sapiens	47-70
26646778-8	2016	Our results also indicated that expressions of interleukin (IL)-1alpha, IL-1beta, IL-6, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in gut tissue were downregulated by treatments of TFDG, and immunity cytokine secretions in the serum were regulated after oral administration of TFDG.	tfdg	325-329	interleukin 1 alpha	Homo sapiens	47-70
26814891-5	2016	Women using injectable DMPA had increased concentration of several soluble proteins of the innate and adaptive immune system, including IL-1alpha, IL-1beta, IL-2, MIP-1beta, IP-10, IL-8, TGF-beta, HBD4, IgA, IgG1, and IgG2.	N,N-dimethyl-4-anisidine	23-27	interleukin 1 alpha	Homo sapiens	136-145
27941341-8	2016	Sulodexide also reduced, in a dose- dependent manner, secretion of IL6 from unstimulated and stimulated with IL-1 endothelial cells.	glucuronyl glucosamine glycan sulfate	0-10	interleukin 1 alpha	Homo sapiens	109-113
26909786-7	2016	DEX+TIVA use was associated with a significant reduction in IL-1, IL-6, TNF-alpha, and INF-gamma (P&lt;0.0001) levels compared with TIVA (two-way ANOVA).	dex+tiva	0-8	interleukin 1 alpha	Homo sapiens	60-64
26909786-7	2016	DEX+TIVA use was associated with a significant reduction in IL-1, IL-6, TNF-alpha, and INF-gamma (P&lt;0.0001) levels compared with TIVA (two-way ANOVA).	tiva	4-8	interleukin 1 alpha	Homo sapiens	60-64
26909786-10	2016	DEX as an adjuvant in anesthesia reduced circulating IL-1, IL-6, TNF-alpha, and INF-gamma levels after mini-CPB.	Dexmedetomidine	0-3	interleukin 1 alpha	Homo sapiens	53-57
26340924-4	2016	Phosphoamino acid mapping and mutation analysis of NKRF further suggest that only Ser phosphorylation within aa 421-429 is regulated by IL-1 stimulation.	Serine	82-85	interleukin 1 alpha	Homo sapiens	136-140
26505274-3	2015	In addition, the branched IL 1-(2-methylpropyl)-3-methylimidazolium bistriflimide ([2mC3C1Im][NTf2]) was found to have an abnormally high viscosity.	(2-methylpropyl)-3-methylimidazolium bistriflimide	31-81	interleukin 1 alpha	Homo sapiens	26-30
28853786-0	2016	A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid.	Alcohols	58-65	interleukin 1 alpha	Homo sapiens	107-120
28853786-0	2016	A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid.	Chlorhexidine	71-84	interleukin 1 alpha	Homo sapiens	107-120
28853786-0	2016	A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid.	Oils, Volatile	89-103	interleukin 1 alpha	Homo sapiens	107-120
26655640-3	2015	Our results showed that dioscin significantly attenuated hepatic stellate cells (HSCs) activation, improved collagen accumulation, and attenuated inflammation through down-regulating the levels of myeloid differentiation factor 88 (MyD88), nuclear factor kappaB (NF-kappaB), interleukin (IL)-1, IL-6 and tumour necrosis factor-alpha by decreasing Toll-like receptor (TLR)4 expression both in vivo and in vitro.	dioscin	24-31	interleukin 1 alpha	Homo sapiens	275-293
26232334-5	2015	Therefore, the aim of this study is to investigate the effect of IL-1alpha on ADAMTS-2 and ADAMTS-3 gene expression in osteoblast like cells, Saos-2 and MG-63.	Magnesium	153-155	interleukin 1 alpha	Homo sapiens	65-74
26505274-3	2015	In addition, the branched IL 1-(2-methylpropyl)-3-methylimidazolium bistriflimide ([2mC3C1Im][NTf2]) was found to have an abnormally high viscosity.	[2mc3c1im][ntf2	83-98	interleukin 1 alpha	Homo sapiens	26-30
26407132-3	2015	The IL 1-ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]) is one of the most efficient cellulose solvents known, greatly altering cellulose structure for improved enzymatic saccharification.	ethyl-3-methylimidazolium acetate	9-42	interleukin 1 alpha	Homo sapiens	4-8
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	interleukin 1 alpha	Homo sapiens	141-149
26407132-3	2015	The IL 1-ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]) is one of the most efficient cellulose solvents known, greatly altering cellulose structure for improved enzymatic saccharification.	[c2c1im][oac	44-56	interleukin 1 alpha	Homo sapiens	4-8
26407132-3	2015	The IL 1-ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]) is one of the most efficient cellulose solvents known, greatly altering cellulose structure for improved enzymatic saccharification.	Cellulose	88-97	interleukin 1 alpha	Homo sapiens	4-8
26407132-3	2015	The IL 1-ethyl-3-methylimidazolium acetate ([C2C1Im][OAc]) is one of the most efficient cellulose solvents known, greatly altering cellulose structure for improved enzymatic saccharification.	Cellulose	131-140	interleukin 1 alpha	Homo sapiens	4-8
26964355-1	2015	Effect of human inherent immunity factors of, a gene-encoded antibacterial peptide indolicidin (Ind) and a cytokine interleukin 1 (IL1) on formation of antibiotic-tolerant persister cells surviving in the presence of ciprofloxacin (Cpf, 100 mug/mL) and ampicillin (Amp, 100 mug/mL) in submerged bacterial cultures (Staphylococcus aureus FGA 209P, Escherichia coli K12, and Pseudomonas aeruginosa PAO1) was studied.	Ciprofloxacin	217-230	interleukin 1 alpha	Homo sapiens	131-134
26506473-6	2015	This effect was observed on the specific activation of the inflammasome absent in melanoma 2 (AIM2), which led to higher cytoplasmic calcium release responsible for calpain activation underlying IL-1alpha release.	Calcium	133-140	interleukin 1 alpha	Homo sapiens	195-204
26506473-7	2015	The blockade of type I interferon receptor and of AIM2 via the addition of LL-37 significantly reduced the release of IL-1alpha, which was still high after Nod-like receptor P3 inhibition via glibenclamide.	Glyburide	192-205	interleukin 1 alpha	Homo sapiens	118-127
26506473-8	2015	More important, mitochondrial-derived reactive oxygen species sequester diminished AIM2-dependent IL-1alpha release.	Reactive Oxygen Species	38-61	interleukin 1 alpha	Homo sapiens	98-107
26964355-1	2015	Effect of human inherent immunity factors of, a gene-encoded antibacterial peptide indolicidin (Ind) and a cytokine interleukin 1 (IL1) on formation of antibiotic-tolerant persister cells surviving in the presence of ciprofloxacin (Cpf, 100 mug/mL) and ampicillin (Amp, 100 mug/mL) in submerged bacterial cultures (Staphylococcus aureus FGA 209P, Escherichia coli K12, and Pseudomonas aeruginosa PAO1) was studied.	Ampicillin	253-263	interleukin 1 alpha	Homo sapiens	131-134
26964355-1	2015	Effect of human inherent immunity factors of, a gene-encoded antibacterial peptide indolicidin (Ind) and a cytokine interleukin 1 (IL1) on formation of antibiotic-tolerant persister cells surviving in the presence of ciprofloxacin (Cpf, 100 mug/mL) and ampicillin (Amp, 100 mug/mL) in submerged bacterial cultures (Staphylococcus aureus FGA 209P, Escherichia coli K12, and Pseudomonas aeruginosa PAO1) was studied.	Ampicillin	265-268	interleukin 1 alpha	Homo sapiens	131-134
26964355-5	2015	IL1, another immunity factor, when introduced (0.1-1 ng/mL) to the exponentially growing S. aureus culture (but not to the lag phase culture) had a temporary growth-static effect, with the number of persisters surviving Cpf treatment (100 mug/mL) increasing by 1 to 2 orders of magnitude.	Ciprofloxacin	220-223	interleukin 1 alpha	Homo sapiens	0-3
26339979-6	2015	Our results showed that endotoxin nanovesicles with such dense lipid A units can elicit the stronger inflammatory gene expressions, including interleukin 6 (IL-6), IL-1A, TNF-alpha, C-X-C chemokine ligand (CXCL) 1, 2, and 11, which have characteristics of T-helper 1 adjuvants.	Lipid A	63-70	interleukin 1 alpha	Homo sapiens	164-169
26397147-0	2015	Effect of cadmium on the expression levels of interleukin-1alpha and interleukin-10 cytokines in human lung cells.	Cadmium	10-17	interleukin 1 alpha	Homo sapiens	46-64
26543364-12	2015	Experimental results showed that MTX-LNC had the same effect as MTX on arthritis inhibition on day 28 of the experiment (P&lt;0.0001); however, this effect was achieved earlier, on day 21 (P&lt;0.0001), by MTX-LNC, and this formulation had reduced both TNF-alpha (P=0.001) and IL-1alpha (P=0.0002) serum levels by the last day of the experiment.	Methotrexate	33-36	interleukin 1 alpha	Homo sapiens	277-286
26543364-12	2015	Experimental results showed that MTX-LNC had the same effect as MTX on arthritis inhibition on day 28 of the experiment (P&lt;0.0001); however, this effect was achieved earlier, on day 21 (P&lt;0.0001), by MTX-LNC, and this formulation had reduced both TNF-alpha (P=0.001) and IL-1alpha (P=0.0002) serum levels by the last day of the experiment.	mtx-lnc	33-40	interleukin 1 alpha	Homo sapiens	277-286
26156105-10	2015	Losartan and PDTC reduced the expression of IL-1alpha, MCP-1, and IL-10, and the number of dilated capillaries and capillaries with endothelial detachment.	Losartan	0-8	interleukin 1 alpha	Homo sapiens	44-53
26431210-11	2015	Iron level is positively correlated with the levels of NO and IL-1beta in PD group.	Iron	0-4	interleukin 1 alpha	Homo sapiens	62-70
26001859-14	2015	In three patients, anti-IL1 treatment could be stopped and they are fine with colchicine.	Colchicine	78-88	interleukin 1 alpha	Homo sapiens	24-27
26341987-6	2015	Sputum interleukin (IL)-6 and growth-regulated oncogene (GRO)-alpha and serum GRO-alpha, IL-1ss and IL-8 levels increased with AZD5069 versus placebo (all p&lt;0.001), while serum high-sensitivity C-reactive protein levels did not change.	N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide	127-134	interleukin 1 alpha	Homo sapiens	89-93
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Flavonoids	28-37	interleukin 1 alpha	Homo sapiens	260-268
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Rutin	50-55	interleukin 1 alpha	Homo sapiens	260-268
26761477-4	2015	RESULTS: Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment.	Cannabidiol	101-112	interleukin 1 alpha	Homo sapiens	44-48
26378384-5	2015	Ammonia correlated positively with IL-1 and IL-6.	Ammonia	0-7	interleukin 1 alpha	Homo sapiens	35-39
25832610-5	2015	The anti-inflammatory activity of NW-21 was assessed using human monocytes stimulated with either TNF-alpha or lipopolysaccharide for 24 h. mRNA expression of monocyte chemotactic protein 1 (MCP-1), TNF-alpha, macrophage inflammatory protein 1alpha (MIP-1alpha), IL-1 and RANTES (regulated on activation, normal T cell expressed and secreted) was assessed.	nw-21	34-39	interleukin 1 alpha	Homo sapiens	263-267
26664582-2	2015	The reactivity was tested in ring opening metathesis polymerization (ROMP) under biphasic conditions using a nonpolar organic solvent (toluene) and the ionic liquid (IL) 1-butyl-2,3-dimethylimidazolium tetrafluoroborate [BDMIM(+)][BF4 (-)].	-2,3-dimethylimidazolium tetrafluoroborate	177-219	interleukin 1 alpha	Homo sapiens	152-171
26048654-7	2015	Exposure to triclosan increased the expression of TSLP, IL-1beta, and TNF-alpha in the skin with concomitant decreases in IL-25, IL-33, and IL-1alpha.	Triclosan	12-21	interleukin 1 alpha	Homo sapiens	140-149