PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
18992279-10	2008	Furthermore, TET inhibited NF-kappaB activity, the critical transcriptional factor of the above mentioned inflammatory cytokines, by preventing the activation of IkappaBalpha kinasealpha (IKKalpha) and then inhibiting phosphorylation of IkappaBalpha to stabilize IkappaBalpha in intrahepatic leukocytes.	tetrandrine	13-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	162-197
18508047-0	2008	Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.	arsenite	48-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	5-13
18508047-4	2008	Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation.	arsenite	39-47	conserved helix-loop-helix ubiquitous kinase	Mus musculus	170-178
18508047-7	2008	Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner.	arsenite	67-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	34-42
17404218-5	2007	Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo.	Serine	76-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	51-59
18222973-11	2008	DA-6034 strongly enhanced apoptosis and inhibited the expression of COX-2 and phospho-IKKalpha in inflammation-related colon cancer models.	recoflavone	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	86-94
17977820-0	2008	Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.	Serine	19-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	52-55
17977820-6	2008	However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the IKK-binding domain plays an essential role for the formation and the function of the IKK complex.	Serine	71-77	conserved helix-loop-helix ubiquitous kinase	Mus musculus	102-105
17977820-8	2008	In contrast, the NEMO-IKKalpha interaction was only mildly affected by the phosphorylation of Ser(68).	Serine	94-97	conserved helix-loop-helix ubiquitous kinase	Mus musculus	22-30
17977820-9	2008	However, functional analysis revealed that Ser(68) phosphorylation primarily affects the activity of IKKalpha.	Serine	43-46	conserved helix-loop-helix ubiquitous kinase	Mus musculus	101-109
18000063-3	2007	The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	213-257	conserved helix-loop-helix ubiquitous kinase	Mus musculus	125-145
18000063-3	2007	The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	213-257	conserved helix-loop-helix ubiquitous kinase	Mus musculus	147-155
18000063-3	2007	The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	259-263	conserved helix-loop-helix ubiquitous kinase	Mus musculus	125-145
18000063-3	2007	The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	259-263	conserved helix-loop-helix ubiquitous kinase	Mus musculus	147-155
18239189-3	2008	We hypothesized that CS activates IKK alpha and causes histone acetylation on the promoters of pro-inflammatory genes, leading to sustained transcription of pro-inflammatory mediators in mouse lung in vivo and in human monocyte/macrophage cell line (MonoMac6) in vitro.	Cesium	21-23	conserved helix-loop-helix ubiquitous kinase	Mus musculus	34-43
18239189-4	2008	CS exposure to C57BL/6J mice resulted in activation of IKK alpha, leading to phosphorylation of ser10 and acetylation of lys9 on histone H3 on the promoters of IL-6 and MIP-2 genes in mouse lung.	Cesium	0-2	conserved helix-loop-helix ubiquitous kinase	Mus musculus	55-64
18239189-7	2008	Overexpression of IKK alpha was associated with augmentation of CS-induced pro-inflammatory effects, and phosphorylation of ser10 and acetylation of lys9 on histone H3, whereas transfection of IKK alpha dominant-negative mutants reduced CS-induced chromatin modification and pro-inflammatory cytokine release.	Cesium	64-66	conserved helix-loop-helix ubiquitous kinase	Mus musculus	18-27
18239189-7	2008	Overexpression of IKK alpha was associated with augmentation of CS-induced pro-inflammatory effects, and phosphorylation of ser10 and acetylation of lys9 on histone H3, whereas transfection of IKK alpha dominant-negative mutants reduced CS-induced chromatin modification and pro-inflammatory cytokine release.	Cesium	237-239	conserved helix-loop-helix ubiquitous kinase	Mus musculus	18-27
18239189-9	2008	Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3.	Cesium	70-72	conserved helix-loop-helix ubiquitous kinase	Mus musculus	40-49
17890319-5	2007	The Ikkalpha(AA) mutation retarded tumor development in response to either 7,12-dimethylbenzaanthracene or the MMTV-c-neu (ErbB2/Her2) transgene but had no effect on MMTV-v-Ha-ras-induced cancer, although both oncogenes rely on cyclin D1.	7,12-dimethylbenzaanthracene	75-103	conserved helix-loop-helix ubiquitous kinase	Mus musculus	4-12
17909021-10	2007	The phorbol ester tumor promoter induced higher mitogenic and angiogenic activities in Ikkalpha+/- than in Ikkalpha+/+ skin.	Phorbol Esters	4-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	87-95
17909021-10	2007	The phorbol ester tumor promoter induced higher mitogenic and angiogenic activities in Ikkalpha+/- than in Ikkalpha+/+ skin.	Phorbol Esters	4-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	107-115
17537731-5	2007	The mutation of IKKalpha putative nuclear localization sequence, which prevents its nuclear translocation, or of crucial serines in the IKKalpha activation loop completely inhibits p65 binding on icam-1 and mcp-1 promoters and rather enhances p65 binding on the ikappabalpha promoter.	Serine	121-128	conserved helix-loop-helix ubiquitous kinase	Mus musculus	136-144
17452332-7	2007	Furthermore, CDDP-mediated accumulation of endogenous p73alpha was not detected in mouse embryonic fibroblasts (MEFs) prepared from IKK-alpha-deficient mice, and CDDP sensitivity was significantly decreased in IKK-alpha-deficient MEFs compared with wild-type MEFs.	Cisplatin	13-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	210-219
17452332-7	2007	Furthermore, CDDP-mediated accumulation of endogenous p73alpha was not detected in mouse embryonic fibroblasts (MEFs) prepared from IKK-alpha-deficient mice, and CDDP sensitivity was significantly decreased in IKK-alpha-deficient MEFs compared with wild-type MEFs.	Cisplatin	162-166	conserved helix-loop-helix ubiquitous kinase	Mus musculus	210-219
17404218-5	2007	Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo.	Serine	76-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	90-102
17404218-5	2007	Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo.	Serine	76-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	90-98
17360634-6	2007	Subsequently, induction of IkappaB kinase-alpha by DeltaNp63alpha initiates epidermal terminal differentiation resulting in the formation of the spinous layer.	deltanp63alpha	51-65	conserved helix-loop-helix ubiquitous kinase	Mus musculus	27-47
17351639-5	2007	Furthermore, we show that IKK1-deficient cells display impaired retinoic acid-induced gene transcription, and that IKK1 is recruited to the promoters of retinoic acid-regulated genes, suggesting that one mechanism by which IKK1 controls epidermal-barrier formation is by regulating the expression of retinoic acid receptor target genes in keratinocytes.	Tretinoin	64-77	conserved helix-loop-helix ubiquitous kinase	Mus musculus	26-30
15829915-11	2005	These results suggest that ROS are implicated in transient downregulation of IKKalpha, beta, and gamma in cerebral ischemia.	Reactive Oxygen Species	27-30	conserved helix-loop-helix ubiquitous kinase	Mus musculus	77-85
16950795-8	2007	9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKKalpha/beta in TPA-treated mouse skin.	11e-	3-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-93
16950795-8	2007	9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKKalpha/beta in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	97-100	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-93
16956889-6	2006	Pharmacological inhibition or antisense ablation of AR that catalyzes the reduction of GS-HNE to GS-DHN prevented PLC, PKC, IKKalpha/beta, and NF-kappaB activation caused by HNE and GS-HNE, but not by GS-DHN, suggesting that reduced GS-lipid aldehydes catalyzed by AR propagate LPS-induced production of inflammatory markers.	gs-dhn	97-103	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-137
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Serine	173-179	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-138
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Serine	187-193	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-138
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Lysine	251-257	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-138
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	166-174
15784689-6	2005	Inhibition of IKK by sulindac decreased IKKalpha phosphorylation, IkappaBalpha phosphorylation and degradation, NF-kappaB activation, and TNF production by BMMC.	Sulindac	21-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	40-48
15784689-10	2005	In addition, IgE + TNP-induced IKKalpha and IkappaBalpha phosphorylation was inhibited by a protein kinase C (PKC) inhibitor Ro 31-8220.	Ro 31-8220	125-135	conserved helix-loop-helix ubiquitous kinase	Mus musculus	31-39
15695520-6	2005	To prove that the kinase activity of IKKalpha was required on a genomic scale, the same physiological rescue was performed with a kinase-dead, ATP binding domain IKKalpha mutant (IKKalpha(K44M)).	Adenosine Triphosphate	143-146	conserved helix-loop-helix ubiquitous kinase	Mus musculus	37-45
15020199-8	2004	Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha.	oleandrin	47-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-154
15122342-9	2004	We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	75-78	conserved helix-loop-helix ubiquitous kinase	Mus musculus	186-194
15020199-8	2004	Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	109-112	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-154
16237959-0	2005	Neuroprotective effect of Chuk-Me-Sun-Dan on NMDA- and AMPA-evoked nitric oxide synthase activity in mouse brain.	N-Methylaspartate	45-49	conserved helix-loop-helix ubiquitous kinase	Mus musculus	26-30
15502405-5	2004	Piceatannol inhibited IkappaB kinase (IKK)-alpha and beta phosphorylation, and subsequently IkappaB-alpha phosphorylation in LPS-stimulated RAW 264.7 cells.	3,3',4,5'-tetrahydroxystilbene	0-11	conserved helix-loop-helix ubiquitous kinase	Mus musculus	22-48
15502405-7	2004	Piceatannol inhibited the phosphorylation of Akt and Raf-1 molecules, which regulated the activation of IKK-alpha and beta phosphorylation.	3,3',4,5'-tetrahydroxystilbene	0-11	conserved helix-loop-helix ubiquitous kinase	Mus musculus	104-113
12403772-3	2003	BMS-345541 (4(2"-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline) was identified as a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC(50) = 0.3 microm, IKK-1 IC(50) = 4 microm).	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	12-71	conserved helix-loop-helix ubiquitous kinase	Mus musculus	174-179
14585967-7	2003	Free NF-kappaB generated by DoxR-induced IkappaB degradation in IKK1/2(-/-) cells is able to activate chromatin based NF-kappaB reporter gene and expression of the endogenous target gene, IkappaBalpha.	Doxorubicin	28-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	64-68
14681684-12	2003	Our data demonstrated that GTP inhibited UVB-induced: (i) activation of NF-kappaB, (ii) activation of IKKalpha, and (iii) phosphorylation and degradation of IkappaBalpha.	Guanosine Triphosphate	27-30	conserved helix-loop-helix ubiquitous kinase	Mus musculus	102-110
12704203-3	2003	For example, mice that carry a mutation in one of the subunits of the IkappaB kinase, IKKalpha, cannot lactate despite the presence of histologically normal alveolar compartment and the expression of milk protein genes.	Lactic Acid	103-110	conserved helix-loop-helix ubiquitous kinase	Mus musculus	86-94
11287960-1	2001	The IKKalpha and IKKbeta catalytic subunits of IkappaB kinase (IKK) share 51% amino-acid identity and similar biochemical activities: they both phosphorylate IkappaB proteins at serines that trigger their degradation.	Serine	178-185	conserved helix-loop-helix ubiquitous kinase	Mus musculus	4-12
12070292-2	2002	Activation of NF-kappaB is critically dependent on serine phosphorylation of the IkappaB protein by the multi-component IkappaB kinase (IKK) containing two catalytic subunits (IKKalpha and IKKbeta) and one regulatory subunit (IKKgamma).	Serine	51-57	conserved helix-loop-helix ubiquitous kinase	Mus musculus	176-184
10593965-0	1999	Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.	Aminosalicylic Acid	0-19	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-49
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	conserved helix-loop-helix ubiquitous kinase	Mus musculus	55-71
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	conserved helix-loop-helix ubiquitous kinase	Mus musculus	73-77
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Octahydrocurcumin	181-198	conserved helix-loop-helix ubiquitous kinase	Mus musculus	55-71
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Octahydrocurcumin	181-198	conserved helix-loop-helix ubiquitous kinase	Mus musculus	73-77
11077049-9	2000	These results suggest that curcumin may exert its anti-inflammatory and anti-carcinogenic properties by suppressing the activation of NFkappaB through inhibition of IKK activity.	Curcumin	27-35	conserved helix-loop-helix ubiquitous kinase	Mus musculus	165-168
10820281-10	2000	Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity.	Sulfhydryl Compounds	92-97	conserved helix-loop-helix ubiquitous kinase	Mus musculus	39-48
10820281-10	2000	Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity.	Cysteine	145-153	conserved helix-loop-helix ubiquitous kinase	Mus musculus	39-48
10593965-6	1999	Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA.	Glutathione	21-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	118-126
10593965-6	1999	Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA.	Mesalamine	185-190	conserved helix-loop-helix ubiquitous kinase	Mus musculus	118-126
10593965-7	1999	Recombinant IKKalpha and IKKbeta autophosphorylation and their phosphorylation of glutathione S-transferase-IkappaBalpha are inhibited by 5-ASA.	Mesalamine	138-143	conserved helix-loop-helix ubiquitous kinase	Mus musculus	12-20
10593965-8	1999	However, IKKalpha serine phosphorylation by its upstream kinase in either intact cells or cellular extracts is not blocked by 5-ASA.	Serine	18-24	conserved helix-loop-helix ubiquitous kinase	Mus musculus	9-17
10593965-10	1999	In summary, 5-ASA inhibits TNFalpha-stimulated IKKalpha kinase activity toward IkappaBalpha in intestinal epithelial cells.	Mesalamine	12-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	47-55
33812054-8	2021	Utilising BAY11-7082 and MG-132, inhibitors of the respective ubiquitin and proteasome pathways essential for NF-kappaB activation, suggested a prospective role for NF-kappaB, or more specifically signalling via IKKalpha/beta.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	25-31	conserved helix-loop-helix ubiquitous kinase	Mus musculus	212-225
10229185-1	1999	IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB.	Serine	143-149	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-30
10229185-1	1999	IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB.	Serine	143-149	conserved helix-loop-helix ubiquitous kinase	Mus musculus	32-41
10229185-1	1999	IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB.	Serine	143-149	conserved helix-loop-helix ubiquitous kinase	Mus musculus	32-35
34747418-5	2021	Furthermore, Uro B inhibited the expression of TLR4, IRAK4, TRAF6, IKK-beta, NF-kappaB p65, and HMGB1 in the small intestine.	urolithin B	13-18	conserved helix-loop-helix ubiquitous kinase	Mus musculus	67-75
34930462-10	2021	Furthermore, we identified that DZNep promoted the receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclast formation via facilitating the phosphorylation of IKKalpha/beta, IkappaB, and subsequently NF-kappaB nuclear translocation, which credit to the EZH2-H3K27me3-Foxc1 axis.	3-deazaneplanocin	32-37	conserved helix-loop-helix ubiquitous kinase	Mus musculus	191-204
34734460-2	2021	We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-kappaB activation by disrupting the association between IKKbeta and NEMO.	N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide	47-54	conserved helix-loop-helix ubiquitous kinase	Mus musculus	70-73
34734460-2	2021	We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-kappaB activation by disrupting the association between IKKbeta and NEMO.	N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide	47-54	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-140
34626855-0	2021	The hepatocyte IKK:NF-kappaB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis.	Cholesterol	98-109	conserved helix-loop-helix ubiquitous kinase	Mus musculus	15-18
34626855-16	2021	CONCLUSIONS: The hepatocytic IKK:NF-kappaB axis is a metabolic regulator by controlling DNL and cholesterol synthesis, independent of its central role in inflammation.	dnl	88-91	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-32
34626855-16	2021	CONCLUSIONS: The hepatocytic IKK:NF-kappaB axis is a metabolic regulator by controlling DNL and cholesterol synthesis, independent of its central role in inflammation.	Cholesterol	96-107	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-32
34352281-0	2021	Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-beta/NEMO interaction in cancer cells.	pterostilbene-isothiocyanate	0-28	conserved helix-loop-helix ubiquitous kinase	Mus musculus	87-95
34649343-12	2021	LPS stimulation dramatically activated NF-kappaB signal pathway, indicated by increased expressions of phosphorylation of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha and the higher p65-DNA binding activity, which were all dose-dependently reversed by Andro-S.	Sulfur	260-262	conserved helix-loop-helix ubiquitous kinase	Mus musculus	137-150
34674107-10	2021	Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals.	linarin	9-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	88-95
34674107-10	2021	Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals.	linarin	9-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-131
34674107-10	2021	Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals.	Cadmium	168-170	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-131
34679653-6	2021	Sesamol suppressed H2O2-induced expression of phospho-IKKalpha, p53, and caspase-3.	sesamol	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	54-62
34291435-4	2021	We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKalpha/beta signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation.	Metformin	47-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	86-99
34291435-8	2021	Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKalpha/beta-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases, such as AD, where such therapeutic intervention could be beneficial.	Metformin	61-70	conserved helix-loop-helix ubiquitous kinase	Mus musculus	76-89
34570444-12	2021	CETSA and DARTS confirmed direct binding of JA to NF-kappaB inhibitor kinase beta (IKKbeta), and overexpression of IKKbeta or knockdown of IkappaBalpha partially rescued the apoptosis induced by JA.	japonicone A	195-197	conserved helix-loop-helix ubiquitous kinase	Mus musculus	83-90
34570444-12	2021	CETSA and DARTS confirmed direct binding of JA to NF-kappaB inhibitor kinase beta (IKKbeta), and overexpression of IKKbeta or knockdown of IkappaBalpha partially rescued the apoptosis induced by JA.	japonicone A	195-197	conserved helix-loop-helix ubiquitous kinase	Mus musculus	115-122
34679653-0	2021	Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKalpha/p53.	sesamol	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	93-101
34463194-12	2021	Taken together, these results suggest that miRNA-451 could regulate the NF-kappaB signaling pathway by targeting IKKbeta, which inhibits glioma cell growth in vitro and in vivo.	mirna-451	43-52	conserved helix-loop-helix ubiquitous kinase	Mus musculus	113-120
34638882-9	2021	Furthermore, GGOH inhibited the phosphorylation of TAK1, IKKalpha/beta, and NF-kappaB p65 proteins as well as NF-kappaB nuclear translocation induced by LPS while maintaining IkappaBalpha expression.	ggoh	13-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	57-70
34679653-6	2021	Sesamol suppressed H2O2-induced expression of phospho-IKKalpha, p53, and caspase-3.	Hydrogen Peroxide	19-23	conserved helix-loop-helix ubiquitous kinase	Mus musculus	54-62
34243622-16	2021	TP dose-dependently inhibited the activation of NF-kappaB pathway induced by LPS, indicated by the changes of phosphorylations of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha, and weakened p65-DNA binding activity.	triptolide	0-2	conserved helix-loop-helix ubiquitous kinase	Mus musculus	145-158
34062371-11	2021	A20/inhibitor of NF-kappaB kinase 2 (IKKbeta)-double knockout mice were resistant to DSS-induced colitis.	dss	85-88	conserved helix-loop-helix ubiquitous kinase	Mus musculus	37-44
34422538-7	2021	We also observed that CC34 exerted anti-inflammatory activity by suppressing the phosphorylation of IKKbeta, IkappaBalpha, and NF-kappaB p65 in vitro.	cc34	22-26	conserved helix-loop-helix ubiquitous kinase	Mus musculus	100-107
34485533-13	2021	Ectopic expression of TGM2 or constitutively active IKKbeta (CA-IKKbeta) can compromise propofol-induced anti-inflammatory effects.	Propofol	88-96	conserved helix-loop-helix ubiquitous kinase	Mus musculus	52-59
34372877-8	2021	Finally, western blot analysis was used to determine the expression of signaling proteins and IKKbeta inhibitor SC-514 was used to validate the involved signaling pathway.	SC 514	112-118	conserved helix-loop-helix ubiquitous kinase	Mus musculus	94-101
34372877-13	2021	Furthermore, IKKbeta inhibitor SC-514 was also used to validate this signaling pathway.	SC 514	31-37	conserved helix-loop-helix ubiquitous kinase	Mus musculus	13-20
34293804-6	2021	Further evaluation demonstrated that compared with suffrutines A, suffrutines B could more significantly inhibit the phosphorylation of IKKalpha/beta, the degradation of IkappaBalpha, and the nuclear translocation of the p65 and p52 subunits in the canonical and non-canonical nuclear factor-kappaB pathways.	suffrutines b	66-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	136-149
34262422-3	2021	Objective: This research study aimed at determining the protective effect of PU on insulin resistance and to uncover the underlying mechanism based on the gut microbiota, IKKbeta/NF-kappaB pathway, and autophagy.	punicalagin	77-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	171-178
34262422-9	2021	Conclusion: PU can improve HFD-induced insulin resistance, improved liver glucose and lipid metabolism disorder and liver injury, and the potential mechanism is that PU inhibited the IKKbeta/NF-kappaB inflammatory pathway by regulating gut microbiota homeostasis and up-regulating liver autophagy activity.	punicalagin	166-168	conserved helix-loop-helix ubiquitous kinase	Mus musculus	183-190
35546047-7	2022	Cyn treatment reduced hind paw swelling and M1 macrophage infiltration, suppressed the mRNA expression of inflammatory factors, and inhibited NLRP3 inflammasome activation in vivo, in addition to inhibiting the phosphorylation of IKKa/beta, p65, and c-Jun NH 2-terminal kinase (JNK).	cynarine	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	230-239
34074311-12	2021	In db/db mice, PS-341 administration led to downregulation of Nur77/IKKbeta/NF-kappaB expression in visceral fat and liver, and alleviation of hyperglycaemia, hypertension, and glucose intolerance.	Bortezomib	15-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	68-75
34162163-6	2021	In addition, TH-GLs significantly down-regulated the protein expression levels of TNF-alpha, IKK-beta, and nuclear factor-kappaB (NF-kappaB).	th-gls	13-19	conserved helix-loop-helix ubiquitous kinase	Mus musculus	93-101
34240224-10	2021	Quinine ameliorated skin damage in the AD-like mice, reduced IgE expression in the blood, inhibited expression of IKKalpha and NF-kappaB, reduced cytokine secretion, reduced KLK7 expression, reduced scratching frequency, increased FLG expression and repaired the skin barrier.	Quinine	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	114-122
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-165
35321327-0	2022	Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways.	Lactones	14-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	89-102
35321327-0	2022	Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways.	Dextran Sulfate	33-55	conserved helix-loop-helix ubiquitous kinase	Mus musculus	89-102
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	dehydrocostus lactone	13-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Dithiothreitol	52-66	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Sulfhydryl Compounds	81-86	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
33561444-7	2021	According to the in silico predictions, p-coumaric acid reached stable interactions with both the ATP-binding site of IKKbeta as well as the regions within LFA-1, critical for interaction with ICAM-1, thereby suppressing the production of proinflammatory mediators and hindering the neutrophil infiltration, respectively.	p-coumaric acid	40-55	conserved helix-loop-helix ubiquitous kinase	Mus musculus	118-125
35280366-10	2022	Results: IKKalpha and LC3B II/I expression levels were increased both in OGD/R treated N2A cells and dMCAO mice.	dmcao	101-106	conserved helix-loop-helix ubiquitous kinase	Mus musculus	9-17
35280366-12	2022	IKKalpha siRNA significantly decreased the infarct volume and the apparent diffusion coefficient (ADC) related to brain edema, and promoted the neurological outcomes after dMCAO.	dmcao	172-177	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-8
33961837-7	2021	The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor.	Bilirubin	16-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-82
35256937-5	2022	Compared to Ikkbeta WT littermates, lipopolysaccharides (LPS) could induce high mortality rate in Ikkbeta C46A mice which is correlated to breaking the homeostasis by intensively activating p-IkappaBalpha-NF-kappaB signaling and inhibiting phosphorylation of 5" adenosine monophosphate-activated protein kinase (p-AMPK) expression.	Adenosine	262-271	conserved helix-loop-helix ubiquitous kinase	Mus musculus	98-105
35163299-0	2022	IKKalpha Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin.	Apigenin	112-120	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-8
35163299-8	2022	Additionally, we have found that apigenin, a flavonoid with anti-cancer properties, inhibits the expression of IKKalpha and attenuates most of the pro-tumoral EMT changes induced by IKKalpha in mouse tumor keratinocytes.	Apigenin	33-41	conserved helix-loop-helix ubiquitous kinase	Mus musculus	111-119
35163299-8	2022	Additionally, we have found that apigenin, a flavonoid with anti-cancer properties, inhibits the expression of IKKalpha and attenuates most of the pro-tumoral EMT changes induced by IKKalpha in mouse tumor keratinocytes.	Apigenin	33-41	conserved helix-loop-helix ubiquitous kinase	Mus musculus	182-190
35163299-9	2022	Nevertheless, we have found that apigenin only inhibits the expression of the IKKalpha protein when it is localized in the cytoplasm.	Apigenin	33-41	conserved helix-loop-helix ubiquitous kinase	Mus musculus	78-86
33561444-7	2021	According to the in silico predictions, p-coumaric acid reached stable interactions with both the ATP-binding site of IKKbeta as well as the regions within LFA-1, critical for interaction with ICAM-1, thereby suppressing the production of proinflammatory mediators and hindering the neutrophil infiltration, respectively.	Adenosine Triphosphate	98-101	conserved helix-loop-helix ubiquitous kinase	Mus musculus	118-125
33860440-10	2021	While inhibiting mTOR by rapamycin or shmTOR significantly suppressed high glucose-induced activation of NF-kappaB and its regulators IKKbeta and IkappaBalpha, suggesting mTOR is the upstream regulator of NF-kappaB.	Glucose	75-82	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-141
33864813-11	2021	We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway.	Sodium Chloride	132-136	conserved helix-loop-helix ubiquitous kinase	Mus musculus	155-168
33864813-11	2021	We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway.	14,15-epoxy-5,8,11-eicosatrienoic acid	17-26	conserved helix-loop-helix ubiquitous kinase	Mus musculus	155-168
33864813-11	2021	We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway.	Palmitic Acid	115-128	conserved helix-loop-helix ubiquitous kinase	Mus musculus	155-168
33864813-13	2021	The increased urine excretion of glucose and sodium was mediated by decreased renal SGLT2 expression due to inactivation of the IKKalpha/beta/NF-kappaB-induced inflammatory response.	Glucose	33-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	128-141
33864813-13	2021	The increased urine excretion of glucose and sodium was mediated by decreased renal SGLT2 expression due to inactivation of the IKKalpha/beta/NF-kappaB-induced inflammatory response.	Sodium	45-51	conserved helix-loop-helix ubiquitous kinase	Mus musculus	128-141
33069779-10	2021	CONCLUSION: In conclusion, IKKbeta, modulated by DJ-1p-VHL, reduces p-Tau accumulation via autophagy in AD"s disease model.	p-tau	68-73	conserved helix-loop-helix ubiquitous kinase	Mus musculus	27-34
33555623-8	2021	Western blot analysis exhibited TAK1-IKKalpha mediated NFkappaB pathway is also hindered by kaempferol treatment as previously reported in activated T cells.	kaempferol	92-102	conserved helix-loop-helix ubiquitous kinase	Mus musculus	37-45
33523871-4	2021	In this study, we found that IKKbeta ubiquitination on lysine-238 was substantially increased during inflammation.	Lysine	55-61	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-36
32761488-8	2021	In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin.	dioscin	160-167	conserved helix-loop-helix ubiquitous kinase	Mus musculus	79-86
33714889-11	2021	INTERPRETATION: Decreased miR-214-3p activates the NF-kappaB signaling pathway and aggravates OA development through targeting IKKbeta, suggesting miR-214-3p may be a novel therapeutic target for OA.	mir-214-3p	26-36	conserved helix-loop-helix ubiquitous kinase	Mus musculus	127-134
33714889-11	2021	INTERPRETATION: Decreased miR-214-3p activates the NF-kappaB signaling pathway and aggravates OA development through targeting IKKbeta, suggesting miR-214-3p may be a novel therapeutic target for OA.	mir-214-3p	147-157	conserved helix-loop-helix ubiquitous kinase	Mus musculus	127-134
33527006-5	2021	Herein, we identified a naturally derived small molecule NDSM253 that specifically inhibited IKKalpha (Inhibitor of NF-kappaB kinase subunit-alpha), a critical component of TLR4/NF-kappaB signaling.	ndsm253	57-64	conserved helix-loop-helix ubiquitous kinase	Mus musculus	93-101
33527006-8	2021	Administration of these IKK inhibitors in a mouse femoral fracture model showed that NDSM253 suppressed proinflammatory cytokine genes, thereby promoting bone healing, while the other three IKK inhibitors showed a weaker improvement of both bone healing and circulating proinflammatory cytokines.	ndsm253	85-92	conserved helix-loop-helix ubiquitous kinase	Mus musculus	24-27
33527006-9	2021	Collectively, our data suggested that NDSM253 might be an effective inhibitor of IKKalpha that could inhibit inflammatory cytokine action in bone injury.	ndsm253	38-45	conserved helix-loop-helix ubiquitous kinase	Mus musculus	81-89
33510636-8	2020	Consistently, KS23 decreased the expression of TNF-alpha and IL-6 in the supernatant of LPS-stimulated RAW 264.7 cells and inhibited the LPS-induced nuclear translocation of NF-kappaB p65 and the phosphorylation of IKKalpha/beta/IkappaBalpha/NF-kappaB.	ks23	14-18	conserved helix-loop-helix ubiquitous kinase	Mus musculus	215-228
33577041-14	2021	Cell transfection experiments revealed that pcDNA-TLR7 group and Triptolide group had increased TLR7 expression while decreased p-IKKalpha and NF-kappaBp65, decreased proliferation level, and increased cell apoptosis (all p<0.05); while the contrary results were found in siRNA-TLR7 group and Asatone group (all p<0.05); yet without significant difference in pcDNA-TLR7+Asatone group (all p>0.05).	triptolide	65-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	130-138
33456673-12	2020	In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid.	alanylglutamine	30-45	conserved helix-loop-helix ubiquitous kinase	Mus musculus	175-182
33456673-12	2020	In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid.	alanylglutamine	30-45	conserved helix-loop-helix ubiquitous kinase	Mus musculus	183-190
32617861-0	2020	Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKbeta/NF-kappaB Signaling Pathway.	rhoifolin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	105-112
33303821-0	2020	Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKbeta and mTORC1.	Fatty Acids	0-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	111-118
33303821-7	2020	Our results demonstrate that saturated FFA activated the serine/threonine kinases IkappaB kinase (IKK)beta/IkappaBalpha and mTORC1/S6K1, but not protein kinase C and c-jun N-terminal kinase, in podocytes and glomeruli of db/db mice.	Serine	57-63	conserved helix-loop-helix ubiquitous kinase	Mus musculus	98-106
32446381-0	2020	Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKbeta stimulated LOX production.	triptolide	0-10	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-81
32932805-6	2020	Furthermore, diminished activation and nuclear translocation of NF-kappaB were found after quercetin treatment through inhibiting IKKalpha and Ikappabalpha phosphorylation of intensive running mice.	Quercetin	91-100	conserved helix-loop-helix ubiquitous kinase	Mus musculus	130-138
32761008-8	2020	In Hepa1-6 tumor-bearing mice, CDMPR exhibited improved antitumor efficiency with M2-type re-polarization ability by the precise delivery of IKKbeta-siRNA and DOX to M2-type TAMs and tumor cells, respectively.	tams	174-178	conserved helix-loop-helix ubiquitous kinase	Mus musculus	141-148
32442901-9	2020	Further, NF-kappaB activation was also blocked by attenuating the phosphorylation of IkB kinase (IKK alpha/beta) in DSS-induced colitis tissues.	dss	116-119	conserved helix-loop-helix ubiquitous kinase	Mus musculus	97-111
33084638-0	2020	Anti-inflammatory and analgesic activities of indigo through regulating the IKKbeta/IkappaB/NF-kappaB pathway in mice.	Indigo Carmine	46-52	conserved helix-loop-helix ubiquitous kinase	Mus musculus	76-83
33084638-9	2020	In conclusion, indigo exerts significant anti-inflammatory and analgesic activities in mice by inhibiting IKKbeta phosphorylation and reducing the production of important pain mediators, such as PGE2 and COX-2, via the IKKbeta/IkappaB/NF-kappaB pathway.	Indigo Carmine	15-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	106-113
33084638-9	2020	In conclusion, indigo exerts significant anti-inflammatory and analgesic activities in mice by inhibiting IKKbeta phosphorylation and reducing the production of important pain mediators, such as PGE2 and COX-2, via the IKKbeta/IkappaB/NF-kappaB pathway.	Indigo Carmine	15-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	219-226
32761008-6	2020	A transwell assay in vitro and an immunofluorescence assay in Hepa1-6 tumor-bearing mice indicated that CDMPR exhibited a pH-sensitive disassembly ability in tumor tissue, IKKbeta-siRNA was precisely delivered to M2-type TAMs and DOX was internalized into tumor cells.	tams	221-225	conserved helix-loop-helix ubiquitous kinase	Mus musculus	172-179
32761008-6	2020	A transwell assay in vitro and an immunofluorescence assay in Hepa1-6 tumor-bearing mice indicated that CDMPR exhibited a pH-sensitive disassembly ability in tumor tissue, IKKbeta-siRNA was precisely delivered to M2-type TAMs and DOX was internalized into tumor cells.	Doxorubicin	230-233	conserved helix-loop-helix ubiquitous kinase	Mus musculus	172-179
32640590-6	2020	LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65.	Reactive Oxygen Species	22-45	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
32640590-6	2020	LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65.	Serine	70-76	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
32640590-8	2020	Consequently, DAC reduced the phosphorylation of IKKalpha/beta to block the nuclear localization of p65, which decreased NF-kappaB activation.	dauricine	14-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	49-62
32448281-12	2020	Intriguingly, DHT could upregulate nuclear expression of TFEB and reduce expressions of p-IKKalpha/beta and p-NF-kappaB.	Dihydrotestosterone	14-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	90-103
32020377-0	2020	Suppression of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma through IKKbeta inhibition.	Cisplatin	54-63	conserved helix-loop-helix ubiquitous kinase	Mus musculus	120-127
32378169-11	2020	There was decline of IKK-beta and NF-kappaB-P65 and elevation of IkappaB-alpha in the N-acetylcysteine group, which was even significantly in the Budesonide group (P < 0.01).	Acetylcysteine	86-102	conserved helix-loop-helix ubiquitous kinase	Mus musculus	21-29
32378169-11	2020	There was decline of IKK-beta and NF-kappaB-P65 and elevation of IkappaB-alpha in the N-acetylcysteine group, which was even significantly in the Budesonide group (P < 0.01).	Budesonide	146-156	conserved helix-loop-helix ubiquitous kinase	Mus musculus	21-29
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	191-199
32004628-13	2020	Trolline significantly down-regulated the protein expression of TLR7 whereas significantly up-regulated the protein expression of TLR4, IKKalpha and TAK1.	trolline	0-8	conserved helix-loop-helix ubiquitous kinase	Mus musculus	136-144
32237724-7	2020	The inhibition of these pathways by BA was once more confirmed by retrovirus infection of constitutively active (CA)-Akt and CA-Ikkbeta retrovirus and measurement of Ca2+ influx.	betulinic acid	36-38	conserved helix-loop-helix ubiquitous kinase	Mus musculus	128-135
32020377-1	2020	We explored the role of the transcription factor, NF-kappaB, and its upstream kinase IKKbeta in regulation of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma (HNSCC).	Cisplatin	149-158	conserved helix-loop-helix ubiquitous kinase	Mus musculus	85-92
32020377-2	2020	We showed that cisplatin-resistant HNSCC cells have a stronger ability to migrate and invade, as well as display higher IKKbeta/NF-kappaB activity compared to their parental partners.	Cisplatin	15-24	conserved helix-loop-helix ubiquitous kinase	Mus musculus	120-127
32020377-8	2020	Our data demonstrated the crucial role of IKKbeta in control of migration, invasion, and metastasis, and implicated that targeting IKKbeta may be a potential therapy for cisplatin-resistant metastatic HNSCC.	Cisplatin	170-179	conserved helix-loop-helix ubiquitous kinase	Mus musculus	131-138
31866511-8	2020	Molecular docking and molecular dynamic (MD) simulation assay were performed to verify the binding between Arg and IKKalpha/IKKbeta.	arenobufagin	107-110	conserved helix-loop-helix ubiquitous kinase	Mus musculus	115-123
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	Adenosine Triphosphate	26-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	48-56
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	Adenosine Triphosphate	26-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	274-282
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	48-56
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	147-150	conserved helix-loop-helix ubiquitous kinase	Mus musculus	48-56
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	274-282
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	147-150	conserved helix-loop-helix ubiquitous kinase	Mus musculus	274-282
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	Adenosine Triphosphate	166-169	conserved helix-loop-helix ubiquitous kinase	Mus musculus	48-56
31479750-2	2019	In the current study, we identified a novel IKKbeta inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis.	ellipticine	63-74	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-51
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	Adenosine Triphosphate	166-169	conserved helix-loop-helix ubiquitous kinase	Mus musculus	274-282
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	147-150	conserved helix-loop-helix ubiquitous kinase	Mus musculus	48-56
31866511-14	2020	Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha.	arenobufagin	147-150	conserved helix-loop-helix ubiquitous kinase	Mus musculus	274-282
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-87
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	triptolide	51-53	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-87
31618063-5	2019	Therefore, we hypothesized that IKKbeta-dependent NF-kappaB activation in monocytes and macrophages plays a role in IHH-induced PA atherosclerosis.	ihh	116-119	conserved helix-loop-helix ubiquitous kinase	Mus musculus	32-39
31618063-11	2019	Our findings demonstrate that IKKbeta-dependent NF-kappaB activity in myeloid-lineage cells plays a critical role in IHH-induced PA atherosclerosis at the early stage.	ihh	117-120	conserved helix-loop-helix ubiquitous kinase	Mus musculus	30-37
31827674-8	2019	Moreover, aloin inhibited hepatocyte apoptosis and inflammatory response that was caused by the upregulated expression of Bcl-2, the downregulated expression of cleaved caspase3(C-caspase3), Bax, Toll-like receptor 4 (TLR4), FADD, MyD88, TRAF6, phosphorylated IKKalpha/beta (p-IKKalpha/beta), and phosphorylated nuclear factor kappaB p65 (p-NF-kappaB p65).	alloin	10-15	conserved helix-loop-helix ubiquitous kinase	Mus musculus	260-273
31792060-3	2019	In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context.	Tamoxifen	76-85	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-52
31792060-3	2019	In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context.	Tamoxifen	87-90	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-52
31792060-3	2019	In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context.	Tamoxifen	87-90	conserved helix-loop-helix ubiquitous kinase	Mus musculus	150-158
31792060-3	2019	In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context.	Urethane	250-258	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-52
31792060-3	2019	In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context.	Urethane	250-258	conserved helix-loop-helix ubiquitous kinase	Mus musculus	150-158
32042747-11	2019	Results: In vitro, we observed that GENT reduced the inflammatory cytokine production of BMMs stimulated by (LPS)/IFN-gamma and ameliorated the phosphorylation of IKKalpha/beta and p65, the degradation of IkappaBalpha, and the translocation of p65 into the nucleus.	gentiopicroside	36-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	163-176
31744501-11	2019	DOX also caused the increase in the expression of IKK-alpha and iNOS and produced a large amount of NO, resulting in the accumulation of nitrotyrosine in the heart tissue.	Doxorubicin	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	50-59
31744501-13	2019	CONCLUSIONS: SMI could recover inflammatory cytokine levels and suppress the expression of IKK-alpha and iNOS in vivo, which was increased by DOX.	Doxorubicin	142-145	conserved helix-loop-helix ubiquitous kinase	Mus musculus	91-100
31781591-9	2019	Moreover, DSS-induced elevation of phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and NF-kappaB (p65) was remarkably blunted by dihydroartemisinin both in vivo and in vitro, indicating an inhibitive property on the PI3K/AKT and NF-kappaB signaling pathways.	artenimol	135-153	conserved helix-loop-helix ubiquitous kinase	Mus musculus	65-73
31479750-2	2019	In the current study, we identified a novel IKKbeta inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis.	ellipticine	76-79	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-51
31479750-8	2019	The results demonstrated that the inhibitory effect of ELL on IKKbeta activity was impaired in the mutation, implying that anti-inflammatory effect of ELL was partially attributed to binding on cysteine 46.	Cysteine	194-202	conserved helix-loop-helix ubiquitous kinase	Mus musculus	62-69
31088970-4	2019	In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion.	Serine	44-50	conserved helix-loop-helix ubiquitous kinase	Mus musculus	17-24
31552024-8	2019	IKKbeta-deficient mice also had distinct differences in colonic tissue-associated and luminal microbiome that may confer protection against C. rodentium.	Phenobarbital	86-93	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-7
30937840-7	2019	Moreover, we found that tizoxanide inhibited the phosphorylation of IKK-alpha and degradation of IkappaB by LPS in macrophage cells.	tizoxanide	24-34	conserved helix-loop-helix ubiquitous kinase	Mus musculus	68-77
30951845-10	2019	Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells.	cs-me	24-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-137
31222033-4	2019	To this end, we induced specific IKKalpha knockout in adult chondrocytes in AcanCreERT2/+; IKKalphaf/f mice treated with tamoxifen (cKO).	Tamoxifen	121-130	conserved helix-loop-helix ubiquitous kinase	Mus musculus	33-41
31222033-4	2019	To this end, we induced specific IKKalpha knockout in adult chondrocytes in AcanCreERT2/+; IKKalphaf/f mice treated with tamoxifen (cKO).	CKO	132-135	conserved helix-loop-helix ubiquitous kinase	Mus musculus	33-41
31222033-8	2019	Interestingly, in spite of the protection from structural articular cartilage damage, the postnatal growth plates of IKKalpha cKO mice after DMM displayed abnormal architecture and composition associated with increased chondrocyte apoptosis, which were not as evident in the articular chondrocytes of the same animals.	dimethylmyleran	141-144	conserved helix-loop-helix ubiquitous kinase	Mus musculus	117-125
31506437-3	2019	IMD 0354 is a selective molecular inhibitor of inhibitor of NF-kappaB kinase subunit beta (IKKbeta) and effective for treatment of acute and subacute inflammatory diseases through the suppression of NF-kappaB activation.	N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide	0-8	conserved helix-loop-helix ubiquitous kinase	Mus musculus	91-98
31088970-4	2019	In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion.	Serine	52-53	conserved helix-loop-helix ubiquitous kinase	Mus musculus	17-24
31088970-4	2019	In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion.	polyglutamine	126-131	conserved helix-loop-helix ubiquitous kinase	Mus musculus	17-24
31088970-5	2019	To investigate the in vivo relationship of IKKbeta to HTT S13 phosphorylation and HD progression, we crossed conditional tamoxifen-inducible IKKbeta knockout mice with R6/1 HD mice.	Tamoxifen	121-130	conserved helix-loop-helix ubiquitous kinase	Mus musculus	141-148
31105857-7	2019	In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway.	Vitamin D	221-230	conserved helix-loop-helix ubiquitous kinase	Mus musculus	60-80
30856390-8	2019	IMX treatment promotes the inhibitory phosphorylation of GSK-3beta at Ser9 and moreover, a marked reduction in the phosphorylation of IKK-beta, which prevents translocation and activation of NF-kappaB.	indirubin-3'-monoxime	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-142
29644554-5	2018	The anti-inflammatory effect of curcumin was associated with the repression of phosphorylation of IKKalpha-IKKbeta, and JNK.	Curcumin	32-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	98-123
30858802-9	2019	In vivo, vildagliptin suppressed the expressions of PCNA and alpha-SMA, phospho-p65, phospho-IKKalpha/beta, GRP78 and CHOP, as well as IRE-1 in vascular smooth muscle cells (VSMCs).	Vildagliptin	9-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	93-101
30359174-6	2019	Metformin reduced levels of the NFkappaB signaling components p-IKKalpha/beta, p-NFkappaB, p-IkappaBalpha in colorectal mucosal cells.	Metformin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	64-77
30618760-9	2018	Pretreatment with costunolide could reduce the expression of toll-like receptor 4, myeloid differentiation factor 88, p65 (Nucleus), phosphorylated IkappaB kinase alpha/beta, inhibitor of nuclear factor kappa-B kinase, inhibitor kappa Balpha and prevent the expression of phosphorylated inhibitor kappa B kinase which repressed translocation of p65 from cytoplasm to nucleus.	costunolide	18-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	148-241
30740911-0	2019	Isoalantolactone inhibits IKKbeta kinase activity to interrupt the NF-kappaB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma.	isoalantolactone	0-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	26-33
30746687-8	2019	In the further mechanism studies, we found that the anti-inflammatory effect of myricetin was mediated by inhibiting LPS-induced phosphorylation of AKT, IKK-alpha, IkappaB-alpha, and P65 in vivo and in vitro.	myricetin	80-89	conserved helix-loop-helix ubiquitous kinase	Mus musculus	153-162
31679314-10	2019	Finally, we found that D-pinitol reserved the TRAF3, NIK, IKKalpha, and RelB in the psoriatic skin, signifying that it restrains the commencement of NF-kappaB signaling pathways.	pinitol	23-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	58-66
30598682-6	2018	Moreover, Ac-ME was shown to inhibit the NF-kappaB pathway, according to the luciferase reporter gene assay performed with a NF-kappaB-Luc construct containing NF-kappaB-binding promoter regions under MyD88 and TRIF overexpression conditions, and immunoblotting analysis by determining the phospho-form levels of IkappaBalpha, IKKalpha/beta, and p85, a regulatory domain of phosphatidylinositide 3-kinase (PI3K).	ac-me	10-15	conserved helix-loop-helix ubiquitous kinase	Mus musculus	327-340
30223923-9	2018	Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells.	Trifluoroacetic Acid	30-33	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-159
30258447-11	2018	Finally, we found that esculetin inhibited the phosphorylation of IKKalpha and P65 in the psoriatic skin, suggesting that it inhibits the activation of NF-kappaB signaling.	esculetin	23-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	66-74
29129664-5	2018	HsA inhibited phosphorylation of IKKalpha/beta and degradation of IkappaBalpha, resulting in decreased nuclear translocation of nuclear factor-kappaB (NF-kappaB) and its transcriptional activity.	hemistepsin	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	33-46
30214937-7	2018	IKKbeta (inhibitor of nuclear factor kappaB kinase beta)-mediated RORgammat Ser489 phosphorylation induced the AhR-RORgammat interaction.	rorgammat	66-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-7
30214937-7	2018	IKKbeta (inhibitor of nuclear factor kappaB kinase beta)-mediated RORgammat Ser489 phosphorylation induced the AhR-RORgammat interaction.	rorgammat	115-124	conserved helix-loop-helix ubiquitous kinase	Mus musculus	0-7
29374854-9	2018	RESULTS: PA elevated not only phosphorylation of JNK, IRS1 serines, and IKKalpha/beta, but also the expression of IL-6, TNFalpha and IL-1beta in C2C12-GLUT4myc cells.	Palmitic Acid	9-11	conserved helix-loop-helix ubiquitous kinase	Mus musculus	72-85
29532887-10	2018	Additionally, juglanin markedly downregulated inflammatory cytokine secretion and phosphorylated nuclear factor-kappaB (NF-kappaB) expression via inhibiting IKKalpha/IkappaBalpha signaling pathway.	juglanin	14-22	conserved helix-loop-helix ubiquitous kinase	Mus musculus	157-165
29311298-5	2018	In mice, lung-specific Ikkalpha ablation (IkkalphaDeltaLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation.	Reactive Oxygen Species	210-233	conserved helix-loop-helix ubiquitous kinase	Mus musculus	23-31
29311298-5	2018	In mice, lung-specific Ikkalpha ablation (IkkalphaDeltaLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation.	Reactive Oxygen Species	235-238	conserved helix-loop-helix ubiquitous kinase	Mus musculus	23-31
28472283-7	2017	Specifically, we identified that RhoA/ROCK activated IkappaB kinase alpha, which promoted the phosphorylation of p65 on serine 536 (p65 pS536).	Serine	120-126	conserved helix-loop-helix ubiquitous kinase	Mus musculus	53-73
28761990-3	2017	Meanwhile, phosphorylation of inhibitor of kappaBalpha (IkappaBalpha) and IkappaB kinase alpha/beta (IKKalpha/beta), as well as translocation of nuclear factor-kappaB (NF-kappaB) to the nucleus, was suppressed by roburic acid treatment.	Roburic acid	213-225	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-114
28577436-5	2017	In addition, UAA effectively reduced the expression and production of inflammatory mediators, including cytokines and matrix metalloproteinase-1/3 in the knee joint tissue and RA synovial fibroblasts, through the downregulation of IKKalpha/beta, IotakappaBalpha, and nuclear factor-kappaB.	6-Carboxymethyluracil	13-16	conserved helix-loop-helix ubiquitous kinase	Mus musculus	231-288
28842306-7	2017	In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway as the phosphorylated proteins of NF-kappaB, IkappaB kinase (IKK)alpha and IKKbeta in the hippocampus were suppressed after berberine administration.	Berberine	21-30	conserved helix-loop-helix ubiquitous kinase	Mus musculus	189-214
28059488-7	2017	Importantly, pre-treatment of the cells with resveratrol completely abrogated the phosphorylation of ERK1/2, JNK, and IKKalpha/IKKbeta in palmitate treated cells.	Resveratrol	45-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	118-126
28178289-11	2017	Eupatilin suppressed NF-kappaB signaling activities in ischemic brain by reducing IKKalpha/beta phosphorylation, IkappaBalpha phosphorylation, and IkappaBalpha degradation.	eupatilin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	82-90
27865009-7	2017	Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling.	Melatonin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	89-97
27865009-7	2017	Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling.	Fluorouracil	30-34	conserved helix-loop-helix ubiquitous kinase	Mus musculus	89-97
28603455-9	2017	In isolated microglia, TMP attenuated the effects of lipopolysaccharide on the phosphorylation of cytoplasmic IKKalpha/beta and IKB-alpha, and levels of nucleic p65.	tetramethylpyrazine	23-26	conserved helix-loop-helix ubiquitous kinase	Mus musculus	110-123
28208071-0	2017	Anthocyanin suppresses CoCrMo particle-induced osteolysis by inhibiting IKKalpha/beta mediated NF-kappaB signaling in a mouse calvarial model.	Anthocyanins	0-11	conserved helix-loop-helix ubiquitous kinase	Mus musculus	72-85
28208071-9	2017	Furthermore, we confirmed that anthocyanin attenuated osteolysis by blocking NF-kappaB pathway via inhibiting inhibitor of nuclear factor kappa-B kinase alpha/beta (IKKalpha/beta) phosphorylation.	Anthocyanins	31-42	conserved helix-loop-helix ubiquitous kinase	Mus musculus	138-178
28208071-10	2017	In conclusion, our study demonstrated that anthocyanin can protect against CoCrMo particle-induced inflammatory osteolysis via inhibiting the IKKalpha/beta-NF-kappaB pathway, and have a potential therapeutic effect on the treatment of wear particle-induced osteolysis.	Anthocyanins	43-54	conserved helix-loop-helix ubiquitous kinase	Mus musculus	142-150
27836674-2	2017	The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKalpha kinase activity, has been observed in vitro.	N-acetylphenylalanine	15-37	conserved helix-loop-helix ubiquitous kinase	Mus musculus	145-153
27836674-2	2017	The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKalpha kinase activity, has been observed in vitro.	Acecainide	50-54	conserved helix-loop-helix ubiquitous kinase	Mus musculus	145-153
27836674-6	2017	RESULTS: The injection of NAPA significantly improved cartilage thickness (CT) and reduced Chambers and Mankin modified scores and fibrillation index (FI), with weaker MMP13, ADAMTS5, MMP10 and IKKalpha staining.	Acecainide	26-30	conserved helix-loop-helix ubiquitous kinase	Mus musculus	194-202
27836674-8	2017	CONCLUSIONS: NAPA markedly improved the physical structure of articular cartilage while reducing catabolic enzymes, extracellular matrix (ECM) remodeling and IKKalpha expression, showing to be able to exert a chondroprotective activity in vivo.	Acecainide	13-17	conserved helix-loop-helix ubiquitous kinase	Mus musculus	158-166
26490221-12	2015	GTS-21 also suppressed LPS-induced phosphorylation of NF-kappaBp65, IKKalpha/beta, IkappaBalpha, and Akt, as well as NF-kappaB p65 nuclear translocation.	3-(2,4-dimethoxybenzylidene)anabaseine	0-6	conserved helix-loop-helix ubiquitous kinase	Mus musculus	68-81
28039475-6	2017	Moreover, in the DHA-treated mice, enhanced expression and improved distribution integrity of protein GPR120 were observed, which was probably associated with the regulation of TAK1/IKK-alpha/IkB-alpha/p65 pathway.	Docosahexaenoic Acids	17-20	conserved helix-loop-helix ubiquitous kinase	Mus musculus	182-191
27093924-2	2016	The plant hormone osmotin inhibited lipopolysaccharide (LPS)-induced TLR4 downstream signaling, including activation of TLR4, CD14, IKKalpha/beta, and NFkappaB, and the release of inflammatory mediators, such as COX-2, TNF-alpha, iNOS, and IL-1beta.	osmotin	18-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	132-145
26476923-4	2016	Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages.	Dexamethasone	5-18	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-141
26476923-4	2016	Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages.	Quercetin	23-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-141
26931732-5	2016	Furthermore, molecular mechanism studies indicated that alpha-solanine inhibited LPS-induced activation of nuclear factor-kappaB (NF-kappaB) by reducing nuclear translocation of p65, degradation of inhibitory kappaBalpha (IkappaBalpha), and phosphorylation of IkappaB kinasealpha/beta (IKKalpha/beta).	alpha-solanine	56-70	conserved helix-loop-helix ubiquitous kinase	Mus musculus	260-299
29441925-6	2016	We also examined the acetylpuerarin"s effect on the activity of PKC-delta, IKKbeta and caspase-8/caspase-3 pathway.	acetylpuerarin	21-35	conserved helix-loop-helix ubiquitous kinase	Mus musculus	75-82
27144271-10	2016	Pre-treatment with paeonol significantly inhibited IKKalpha/beta, IkappaBalpha and p65 phosphorylation which contributed to ameliorating APAP-induced hepatic inflammation.	paeonol	19-26	conserved helix-loop-helix ubiquitous kinase	Mus musculus	51-64
27002412-13	2016	Treatment of the RAW cells with aloin suppressed RANKL-induced NF-kappaB pathway components like IKKalpha, IKKbeta, Phospho.IKK alpha/beta, NF-kappaB-p65, Phospho NF-kappaB-p65 and IkappaBalpha.	alloin	32-37	conserved helix-loop-helix ubiquitous kinase	Mus musculus	97-105
26848161-5	2016	Moreover, IKKalpha null macrophages treated with lipotoxic palmitic acid exhibited early exhaustion of Akt signaling compared with wild-type cells.	Palmitic Acid	59-72	conserved helix-loop-helix ubiquitous kinase	Mus musculus	10-18
25401971-10	2015	Furthermore, Western blot and morphological results showed that melatonin treatment significantly reduced D-galactose-induced neuroinflammation through inhibition of microgliosis (Iba-1) and astrocytosis (GFAP), and downregulating other inflammatory mediators such as p-IKKbeta, p-NF-K B65, COX2, NOS2, IL-1beta, and TNFalpha.	Melatonin	64-73	conserved helix-loop-helix ubiquitous kinase	Mus musculus	270-277
25749152-5	2015	reduced blood glucose levels significantly and increased the protein expressions of insulin receptor beta, insulin receptor substrate 1, protein kinase B (Akt/PKB), IKKalpha, and IkappaBalpha.	Glucose	14-21	conserved helix-loop-helix ubiquitous kinase	Mus musculus	165-173
26285901-4	2015	Mechanistic studies show that MLB counteracts Abeta (1-42)-induced activation of the nuclear factor kappa B (NF-kappaB) pathway, evidenced by the suppression of NF-kappaB luciferase reporters, decreased expression of phosphorylated Inhibitor kappaB alpha and IkappaB kinase alpha, and reduced nuclear translocation of p65 in response to pre-treatment with 50 mug/ml MLB prior to Abeta (1-42) exposure.	UNII-042A8N37WH	46-51	conserved helix-loop-helix ubiquitous kinase	Mus musculus	259-279
25401971-10	2015	Furthermore, Western blot and morphological results showed that melatonin treatment significantly reduced D-galactose-induced neuroinflammation through inhibition of microgliosis (Iba-1) and astrocytosis (GFAP), and downregulating other inflammatory mediators such as p-IKKbeta, p-NF-K B65, COX2, NOS2, IL-1beta, and TNFalpha.	Galactose	106-117	conserved helix-loop-helix ubiquitous kinase	Mus musculus	270-277
25519833-8	2015	Furthermore, bornyl cinnamate significantly blocked the lipopolysaccharide-induced activation of I-kappaB kinase alpha, an upstream kinase of the inhibitor of nuclear factor kappaB alpha.	bornyl cinnamate	13-29	conserved helix-loop-helix ubiquitous kinase	Mus musculus	97-118
24498990-0	2014	A novel IKKalpha inhibitor, noraristeromycin, blocks the chronic inflammation associated with collagen-induced arthritis in mice.	5'-noraristeromycin	28-44	conserved helix-loop-helix ubiquitous kinase	Mus musculus	8-16
24999035-9	2014	MiR-223 was inversely upregulated in IBE-treated cells; overexpression of miR-223 decreased the expression of miR-27b by suppressing IKKalpha expression.	ibe	37-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-141
24498990-1	2014	OBJECTIVES: To evaluate the therapeutic efficacy of a novel inhibitor for IkappaB kinase alpha (IKKalpha), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA).	5'-noraristeromycin	107-123	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-94
24498990-1	2014	OBJECTIVES: To evaluate the therapeutic efficacy of a novel inhibitor for IkappaB kinase alpha (IKKalpha), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA).	5'-noraristeromycin	107-123	conserved helix-loop-helix ubiquitous kinase	Mus musculus	96-104
24886817-6	2014	Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF.	Bleomycin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	46-54
24886817-6	2014	Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF.	Bleomycin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	71-79
24886817-6	2014	Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF.	Bleomycin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	71-79
24955217-5	2014	Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway.	CMPDA	68-73	conserved helix-loop-helix ubiquitous kinase	Mus musculus	171-179
24519526-0	2014	The Ah receptor recruits IKKalpha to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.	Serine	80-86	conserved helix-loop-helix ubiquitous kinase	Mus musculus	25-33
24519526-5	2014	Using chromatin immunoprecipitation with antibodies to a comprehensive set of protein kinases, we identified three kinases, IkappaB kinase alpha (IKKalpha), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells and absent in control c35 cells.	Polychlorinated Dibenzodioxins	337-341	conserved helix-loop-helix ubiquitous kinase	Mus musculus	124-144
24519526-5	2014	Using chromatin immunoprecipitation with antibodies to a comprehensive set of protein kinases, we identified three kinases, IkappaB kinase alpha (IKKalpha), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells and absent in control c35 cells.	Polychlorinated Dibenzodioxins	337-341	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-154
24519526-6	2014	Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells.	Polychlorinated Dibenzodioxins	82-86	conserved helix-loop-helix ubiquitous kinase	Mus musculus	28-36
24519526-6	2014	Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells.	Polychlorinated Dibenzodioxins	260-264	conserved helix-loop-helix ubiquitous kinase	Mus musculus	28-36
24519526-6	2014	Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells.	Polychlorinated Dibenzodioxins	260-264	conserved helix-loop-helix ubiquitous kinase	Mus musculus	131-139
24519526-8	2014	Given the role of H3S10ph in regulation of chromosome condensation, AHR-IKKalpha cross-talk may be a mediator of chromatin remodeling by environmental agents.	h3s10ph	18-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	72-80
24488495-10	2014	The phosphorylation of IKKalpha at threonine 23 and its kinase activity were indispensable for the processing of p100 and osteoclastogenesis by RelB-induced Cot.	Threonine	35-44	conserved helix-loop-helix ubiquitous kinase	Mus musculus	23-31
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	conserved helix-loop-helix ubiquitous kinase	Mus musculus	211-219
24349299-7	2013	Both western blot and luciferase activity assay showed that vinpocetine inhibited the enhanced Akt, IKKalpha/beta, IkappaBalpha phosphorylation and NF-kappaB activity induced by ox-LDL, and the inhibition of NF-kappaB activity was partly caused by Akt dephosphorylation.	vinpocetine	60-71	conserved helix-loop-helix ubiquitous kinase	Mus musculus	100-113
24508132-9	2014	Pre-treatment with MHY884 inhibited Akt and IkappaB kinase alpha/beta signaling pathways, leading to decreased translocation and phosphorylation of p65, a subunit of NF-kappaB.	4-(5-chloro-2,3-dihydrobenzo(d)thiazol-2-yl)-2,6-dimethoxyphenol	19-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-64
23503581-7	2013	Based on the inherent property of Au-NPs to bind to -thiol groups and the presence of cysteine residues on the NF-kappaB signal transduction proteins IkappaB kinases (IKK), proteins specifically bound to Au-NPs were extracted from CH12.LX cellular lysate exposed to 10 nm Au-NPs.	Cysteine	86-94	conserved helix-loop-helix ubiquitous kinase	Mus musculus	167-170
24044575-12	2013	Ex vivo incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKKalpha suppression and concomitant I-kappaB accumulation; increase of IL-6 and TGF-beta; and, decrease of TNF-alpha.	tam	22-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	75-83
24044575-12	2013	Ex vivo incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKKalpha suppression and concomitant I-kappaB accumulation; increase of IL-6 and TGF-beta; and, decrease of TNF-alpha.	epigallocatechin gallate	45-49	conserved helix-loop-helix ubiquitous kinase	Mus musculus	75-83
21656643-4	2013	Taken together, the inflammation of mice liver caused by exposure to CeCl3 might be closely associated with the alteration of inflammatory cytokine expressions in the mouse liver, the signal-transducing events happening in CeCl3-induced macrophages of liver sequentially might occur via activation of TLRs TNF-alpha NIK IkappaB kinase (including IKK1, IKK2) NF-kappaB (including NF-kappaBP52, NF-kappaBP65)  inflammation.	cerous chloride	69-74	conserved helix-loop-helix ubiquitous kinase	Mus musculus	346-350
21656643-4	2013	Taken together, the inflammation of mice liver caused by exposure to CeCl3 might be closely associated with the alteration of inflammatory cytokine expressions in the mouse liver, the signal-transducing events happening in CeCl3-induced macrophages of liver sequentially might occur via activation of TLRs TNF-alpha NIK IkappaB kinase (including IKK1, IKK2) NF-kappaB (including NF-kappaBP52, NF-kappaBP65)  inflammation.	cerous chloride	223-228	conserved helix-loop-helix ubiquitous kinase	Mus musculus	346-350
22889356-3	2013	NCTD inhibited the proliferation of MM cells and potentiated the anti-myeloma effects of BTZ by down-regulating IKKalpha and p-IkappaBalpha, which induced the accumulation of IkappaBalpha and inhibited the constitutive activation of NF-kappaB.	Bortezomib	89-92	conserved helix-loop-helix ubiquitous kinase	Mus musculus	112-120
22181855-6	2012	Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB-induced (1) nuclear translocation and phosphorylation of nuclear factor kappa B/p65, (2) phosphorylation and degradation of IkappaBalpha, (3) activation of IKKalpha/IotaKappaKappabeta and (4) phosphorylation of mitogen-activated protein kinase proteins and c-Jun.	Coconut Oil	54-57	conserved helix-loop-helix ubiquitous kinase	Mus musculus	236-244
22542583-5	2012	Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-kappaB (NF-kappaB) p65 and p50 subunits to the nucleus by blocking IKKalpha/beta (IkappaB kinase alpha/beta) mediated degradation of IkappaBalpha.	paeonol	48-55	conserved helix-loop-helix ubiquitous kinase	Mus musculus	169-182
22542583-5	2012	Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-kappaB (NF-kappaB) p65 and p50 subunits to the nucleus by blocking IKKalpha/beta (IkappaB kinase alpha/beta) mediated degradation of IkappaBalpha.	paeonol	48-55	conserved helix-loop-helix ubiquitous kinase	Mus musculus	184-204
21585385-11	2011	Eugenosedin-A, like atorvastatin, could inhibit p38, ERK, JNK, Akt/IKKalpha/p65 proteins, as well as TNF-alpha and IFN-gamma mRNA during the regulation of the obesity-induced inflammatory process.	eugenosedin-A	0-13	conserved helix-loop-helix ubiquitous kinase	Mus musculus	67-75
22595195-6	2012	Spinasterol-Glc also inhibited phosphorylation of IkappaB-alpha and IKKalpha/beta as well as translocation of NF-kappaB to the nucleus.	3-O-beta-D-glucopyranosyl-spinasterol	0-15	conserved helix-loop-helix ubiquitous kinase	Mus musculus	68-81
21696761-14	2012	At 4 h, 6 of these 22 genes (CHUK, HMGB1, HSPD1, IRAK2, LY96, and TLR4) were further 2-fold increased in the LPS pretreatment group compared with the saline pretreatment group.	Sodium Chloride	150-156	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-33
22447251-4	2012	Western blotting revealed that SNX-2112             lead to the degradation of Hsp90 client proteins including Akt, IKKalpha, NF-kappaB, B-Raf             and GSK3beta.	SNX 2112	31-39	conserved helix-loop-helix ubiquitous kinase	Mus musculus	116-124
23243426-2	2012	Activation of hepatic nuclear factor-kappa B (NF-kappaB), IkappaB kinase (IKK alpha/beta) proteins, and TNFalpha and IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes.	Diethylnitrosamine	153-171	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-83
23243426-2	2012	Activation of hepatic nuclear factor-kappa B (NF-kappaB), IkappaB kinase (IKK alpha/beta) proteins, and TNFalpha and IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes.	Diethylnitrosamine	174-177	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-83
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	conserved helix-loop-helix ubiquitous kinase	Mus musculus	159-167
22340218-9	2011	However, IKKalpha expression was increased after metformin treatment in both tissues.	Metformin	49-58	conserved helix-loop-helix ubiquitous kinase	Mus musculus	9-17
22140508-5	2011	DHA pretreatment also attenuated UVB-induced DNA binding of nuclear factor-kappaB (NF-kappaB) through the inhibition of phosphorylation of IkappaB kinase-alpha/beta, phosphorylation and degradation of IkappaBalpha and nuclear translocation of p50 and p65.	Docosahexaenoic Acids	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	139-159
21420465-8	2011	In addition, Cd markedly increased NF-kappaB nuclear translocation in association with IKKalpha/beta phosphorylation and IkappaBalpha degradation.	Cadmium	13-15	conserved helix-loop-helix ubiquitous kinase	Mus musculus	87-95
20671747-4	2011	3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis.	4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	178-186
20671747-4	2011	3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis.	4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	262-270
20671747-4	2011	3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis.	3-cl	0-4	conserved helix-loop-helix ubiquitous kinase	Mus musculus	262-270
20671747-4	2011	3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis.	ahpc	5-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	178-186
21356367-5	2011	BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor kappaB, IkappaB-kinase alpha/beta, cAMP response element binding and the expression of caspase-3 and Ki-67.	caryophyllene	0-3	conserved helix-loop-helix ubiquitous kinase	Mus musculus	113-133
21887257-4	2011	We hypothesized that CS and TNFalpha increase NIK levels causing phosphorylation of IKKalpha, which leads to histone acetylation.	Cesium	21-23	conserved helix-loop-helix ubiquitous kinase	Mus musculus	84-92
21887257-6	2011	CS increased the phosphorylation levels of IKKalpha/NIK in lung epithelial cells and mouse lungs.	Cesium	0-2	conserved helix-loop-helix ubiquitous kinase	Mus musculus	43-51
21082860-7	2010	Furthermore, theasinensin A suppressed the phosphorylation of MAPKs, IkappaB kinase alpha/beta (IKKalpha/beta), and TGF-beta activated kinase (TAK1).	theasinensin A	13-27	conserved helix-loop-helix ubiquitous kinase	Mus musculus	69-89
21082860-7	2010	Furthermore, theasinensin A suppressed the phosphorylation of MAPKs, IkappaB kinase alpha/beta (IKKalpha/beta), and TGF-beta activated kinase (TAK1).	theasinensin A	13-27	conserved helix-loop-helix ubiquitous kinase	Mus musculus	90-109
19627202-5	2009	Moreover, the antioxidative AMS suppressed the activation of NF-kappaB and its dependent genes such as vascular cell adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 through inhibition of IkappaBalpha phosphorylation and activation of IkappaB kinase alpha/beta and mitogen-activated protein kinases (MAPKs).	allyl methyl sulfide	28-31	conserved helix-loop-helix ubiquitous kinase	Mus musculus	261-281
20132051-8	2010	Pam(3)Cys stimulation of E14 ESCs was associated with induced NF-kappaB translocation, enhanced phosphorylation of IKK-alpha/beta, and enhanced mRNA, but not protein, expression of tumor necrosis factor-alpha, interferon-gamma, and IL-6.	(3)cys	3-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	115-124
20472709-9	2010	Thus, targeted disruption of Glrx1 regulates the lung proinflammatory response via histone acetylation specifically by activation of IKKalpha in response to CS exposure.	Cesium	157-159	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-141
20386985-6	2010	Most importantly, quercetin significantly prevented in vivo growth of ACC xenografts in nude mice, accompanied by induction of tumor cell apoptosis, suppression of NF-kappaB nuclear translocation, as well as down-regulation of Akt and IKK-alpha activation.	Quercetin	18-27	conserved helix-loop-helix ubiquitous kinase	Mus musculus	235-244
19800637-6	2010	In adipose tissue, atorvastatin decreased macrophage infiltration and normalized IKK-alpha/beta phosphorylation; TNF-alpha, IL-6, and GLUT4 mRNA; and GLUT4 protein to control levels.	Atorvastatin	19-31	conserved helix-loop-helix ubiquitous kinase	Mus musculus	81-90
21779445-6	2010	The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases.	Bismuth	65-67	conserved helix-loop-helix ubiquitous kinase	Mus musculus	104-107
21779445-6	2010	The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases.	Bismuth	87-89	conserved helix-loop-helix ubiquitous kinase	Mus musculus	104-107
21779445-6	2010	The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases.	Bismuth	87-89	conserved helix-loop-helix ubiquitous kinase	Mus musculus	198-202
19666475-1	2009	Proinflammatory NF-kappaB activation requires the IkappaB (inhibitor of NF-kappaB) kinase (IKK) complex that contains two catalytic subunits named IKKalpha and IKKbeta and a regulatory subunit named NF-kappaB essential modulator (NEMO).	ikappab	50-57	conserved helix-loop-helix ubiquitous kinase	Mus musculus	147-155
19363130-5	2009	The protein expression of IKK-alpha and IKK-beta were higher in Lepr(db) than in mLepr(db) mice; the expression of IKK-beta, but not the expression of IKK-alpha, was attenuated by MG-132, the antioxidant apocynin, or the genetic deletion of TNF-alpha in diabetic mice.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	180-186	conserved helix-loop-helix ubiquitous kinase	Mus musculus	26-35
20472709-7	2010	Interestingly, phosphorylated and total levels of IKKalpha, but not total and phosphorylated IKKbeta levels, were increased in lungs of Glrx1 KO mice compared with WT mice exposed to CS.	Cesium	183-185	conserved helix-loop-helix ubiquitous kinase	Mus musculus	50-58
19169268-7	2009	Further study revealed that FLZ inhibited the phosphorylation of transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1), which is an upstream signaling molecule required for IKKalpha/beta, JNK and p38 activation.	flz	28-31	conserved helix-loop-helix ubiquitous kinase	Mus musculus	188-201
19278579-2	2009	METHODS: IKKalpha and IKKgamma targeting small interference RNA (siRNA) were designed to synthesize complementary oligonucleotide chains, then it was transfected into mouse macrophage cell line RAW264.7.	Oligonucleotides	114-129	conserved helix-loop-helix ubiquitous kinase	Mus musculus	9-17
18688039-8	2009	Transient transfection of dominant negative IkappaB-kinase-alpha and double mutants of NF-kappaB-inducing kinase partially attenuated the CS extract-mediated loss of RelB in B cells and normalized the increased RelB level in macrophages.	Cesium	138-140	conserved helix-loop-helix ubiquitous kinase	Mus musculus	44-64
18688039-9	2009	Taken together, these data suggest that RelB is differentially regulated in response to CS exposure in macrophages, B cells, and in lung cells by IkappaB-kinase-alpha-dependent mechanism.	Cesium	88-90	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-166
19201823-3	2009	Thalidomide prevented the activation of nuclear factor (NF)-KB by down-regulating phosphorylation of inhibitory KB factor (IKB), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS-induced phosphorylation of AKT, p38 and stress-activated protein kinase (SAPK)/JNK.	Thalidomide	0-11	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-155
19201823-3	2009	Thalidomide prevented the activation of nuclear factor (NF)-KB by down-regulating phosphorylation of inhibitory KB factor (IKB), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS-induced phosphorylation of AKT, p38 and stress-activated protein kinase (SAPK)/JNK.	Thalidomide	179-190	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-155