PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 33812054-8 2021 Utilising BAY11-7082 and MG-132, inhibitors of the respective ubiquitin and proteasome pathways essential for NF-kappaB activation, suggested a prospective role for NF-kappaB, or more specifically signalling via IKKalpha/beta. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 25-31 conserved helix-loop-helix ubiquitous kinase Mus musculus 212-225 34626855-0 2021 The hepatocyte IKK:NF-kappaB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis. Cholesterol 98-109 conserved helix-loop-helix ubiquitous kinase Mus musculus 15-18 34930462-10 2021 Furthermore, we identified that DZNep promoted the receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclast formation via facilitating the phosphorylation of IKKalpha/beta, IkappaB, and subsequently NF-kappaB nuclear translocation, which credit to the EZH2-H3K27me3-Foxc1 axis. 3-deazaneplanocin 32-37 conserved helix-loop-helix ubiquitous kinase Mus musculus 191-204 34734460-2 2021 We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-kappaB activation by disrupting the association between IKKbeta and NEMO. N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide 47-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 70-73 34734460-2 2021 We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-kappaB activation by disrupting the association between IKKbeta and NEMO. N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide 47-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-140 34626855-16 2021 CONCLUSIONS: The hepatocytic IKK:NF-kappaB axis is a metabolic regulator by controlling DNL and cholesterol synthesis, independent of its central role in inflammation. dnl 88-91 conserved helix-loop-helix ubiquitous kinase Mus musculus 29-32 34626855-16 2021 CONCLUSIONS: The hepatocytic IKK:NF-kappaB axis is a metabolic regulator by controlling DNL and cholesterol synthesis, independent of its central role in inflammation. Cholesterol 96-107 conserved helix-loop-helix ubiquitous kinase Mus musculus 29-32 34747418-5 2021 Furthermore, Uro B inhibited the expression of TLR4, IRAK4, TRAF6, IKK-beta, NF-kappaB p65, and HMGB1 in the small intestine. urolithin B 13-18 conserved helix-loop-helix ubiquitous kinase Mus musculus 67-75 34674107-10 2021 Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals. linarin 9-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 88-95 34649343-12 2021 LPS stimulation dramatically activated NF-kappaB signal pathway, indicated by increased expressions of phosphorylation of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha and the higher p65-DNA binding activity, which were all dose-dependently reversed by Andro-S. Sulfur 260-262 conserved helix-loop-helix ubiquitous kinase Mus musculus 137-150 34674107-10 2021 Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals. linarin 9-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 124-131 34674107-10 2021 Besides, linarin suppresses alterations in the inflammatory system, i.e., NF-kappaB p65/IKKbeta, by reducing NF-kappaB p65, IKKbeta, IL-6, and TNF-alpha in the bone of Cd-exposed animals. Cadmium 168-170 conserved helix-loop-helix ubiquitous kinase Mus musculus 124-131 34638882-9 2021 Furthermore, GGOH inhibited the phosphorylation of TAK1, IKKalpha/beta, and NF-kappaB p65 proteins as well as NF-kappaB nuclear translocation induced by LPS while maintaining IkappaBalpha expression. ggoh 13-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 57-70 34291435-4 2021 We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKalpha/beta signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation. Metformin 47-56 conserved helix-loop-helix ubiquitous kinase Mus musculus 86-99 34291435-8 2021 Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKalpha/beta-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases, such as AD, where such therapeutic intervention could be beneficial. Metformin 61-70 conserved helix-loop-helix ubiquitous kinase Mus musculus 76-89 34352281-0 2021 Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-beta/NEMO interaction in cancer cells. pterostilbene-isothiocyanate 0-28 conserved helix-loop-helix ubiquitous kinase Mus musculus 87-95 34463194-12 2021 Taken together, these results suggest that miRNA-451 could regulate the NF-kappaB signaling pathway by targeting IKKbeta, which inhibits glioma cell growth in vitro and in vivo. mirna-451 43-52 conserved helix-loop-helix ubiquitous kinase Mus musculus 113-120 34422538-7 2021 We also observed that CC34 exerted anti-inflammatory activity by suppressing the phosphorylation of IKKbeta, IkappaBalpha, and NF-kappaB p65 in vitro. cc34 22-26 conserved helix-loop-helix ubiquitous kinase Mus musculus 100-107 34679653-6 2021 Sesamol suppressed H2O2-induced expression of phospho-IKKalpha, p53, and caspase-3. sesamol 0-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 54-62 34679653-6 2021 Sesamol suppressed H2O2-induced expression of phospho-IKKalpha, p53, and caspase-3. Hydrogen Peroxide 19-23 conserved helix-loop-helix ubiquitous kinase Mus musculus 54-62 34570444-12 2021 CETSA and DARTS confirmed direct binding of JA to NF-kappaB inhibitor kinase beta (IKKbeta), and overexpression of IKKbeta or knockdown of IkappaBalpha partially rescued the apoptosis induced by JA. japonicone A 195-197 conserved helix-loop-helix ubiquitous kinase Mus musculus 83-90 34570444-12 2021 CETSA and DARTS confirmed direct binding of JA to NF-kappaB inhibitor kinase beta (IKKbeta), and overexpression of IKKbeta or knockdown of IkappaBalpha partially rescued the apoptosis induced by JA. japonicone A 195-197 conserved helix-loop-helix ubiquitous kinase Mus musculus 115-122 34679653-0 2021 Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKalpha/p53. sesamol 0-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 93-101 34485533-13 2021 Ectopic expression of TGM2 or constitutively active IKKbeta (CA-IKKbeta) can compromise propofol-induced anti-inflammatory effects. Propofol 88-96 conserved helix-loop-helix ubiquitous kinase Mus musculus 52-59 34240224-10 2021 Quinine ameliorated skin damage in the AD-like mice, reduced IgE expression in the blood, inhibited expression of IKKalpha and NF-kappaB, reduced cytokine secretion, reduced KLK7 expression, reduced scratching frequency, increased FLG expression and repaired the skin barrier. Quinine 0-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 114-122 34293804-6 2021 Further evaluation demonstrated that compared with suffrutines A, suffrutines B could more significantly inhibit the phosphorylation of IKKalpha/beta, the degradation of IkappaBalpha, and the nuclear translocation of the p65 and p52 subunits in the canonical and non-canonical nuclear factor-kappaB pathways. suffrutines b 66-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 136-149 34262422-3 2021 Objective: This research study aimed at determining the protective effect of PU on insulin resistance and to uncover the underlying mechanism based on the gut microbiota, IKKbeta/NF-kappaB pathway, and autophagy. punicalagin 77-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 171-178 34262422-9 2021 Conclusion: PU can improve HFD-induced insulin resistance, improved liver glucose and lipid metabolism disorder and liver injury, and the potential mechanism is that PU inhibited the IKKbeta/NF-kappaB inflammatory pathway by regulating gut microbiota homeostasis and up-regulating liver autophagy activity. punicalagin 166-168 conserved helix-loop-helix ubiquitous kinase Mus musculus 183-190 34162163-6 2021 In addition, TH-GLs significantly down-regulated the protein expression levels of TNF-alpha, IKK-beta, and nuclear factor-kappaB (NF-kappaB). th-gls 13-19 conserved helix-loop-helix ubiquitous kinase Mus musculus 93-101 34074311-12 2021 In db/db mice, PS-341 administration led to downregulation of Nur77/IKKbeta/NF-kappaB expression in visceral fat and liver, and alleviation of hyperglycaemia, hypertension, and glucose intolerance. Bortezomib 15-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 68-75 34372877-8 2021 Finally, western blot analysis was used to determine the expression of signaling proteins and IKKbeta inhibitor SC-514 was used to validate the involved signaling pathway. SC 514 112-118 conserved helix-loop-helix ubiquitous kinase Mus musculus 94-101 34372877-13 2021 Furthermore, IKKbeta inhibitor SC-514 was also used to validate this signaling pathway. SC 514 31-37 conserved helix-loop-helix ubiquitous kinase Mus musculus 13-20 34062371-11 2021 A20/inhibitor of NF-kappaB kinase 2 (IKKbeta)-double knockout mice were resistant to DSS-induced colitis. dss 85-88 conserved helix-loop-helix ubiquitous kinase Mus musculus 37-44 34243622-16 2021 TP dose-dependently inhibited the activation of NF-kappaB pathway induced by LPS, indicated by the changes of phosphorylations of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha, and weakened p65-DNA binding activity. triptolide 0-2 conserved helix-loop-helix ubiquitous kinase Mus musculus 145-158 35489123-7 2022 Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4. dapt 47-51 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-165 35163299-0 2022 IKKalpha Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin. Apigenin 112-120 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-8 35321327-0 2022 Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways. Lactones 14-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 89-102 35321327-0 2022 Dehydrocostus Lactone Suppresses Dextran Sulfate Sodium-Induced Colitis by Targeting the IKKalpha/beta-NF-kappaB and Keap1-Nrf2 Signalling Pathways. Dextran Sulfate 33-55 conserved helix-loop-helix ubiquitous kinase Mus musculus 89-102 35321327-7 2022 Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1. dehydrocostus lactone 13-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 129-142 35321327-7 2022 Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1. Dithiothreitol 52-66 conserved helix-loop-helix ubiquitous kinase Mus musculus 129-142 35321327-7 2022 Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1. Sulfhydryl Compounds 81-86 conserved helix-loop-helix ubiquitous kinase Mus musculus 129-142 35256937-5 2022 Compared to Ikkbeta WT littermates, lipopolysaccharides (LPS) could induce high mortality rate in Ikkbeta C46A mice which is correlated to breaking the homeostasis by intensively activating p-IkappaBalpha-NF-kappaB signaling and inhibiting phosphorylation of 5" adenosine monophosphate-activated protein kinase (p-AMPK) expression. Adenosine 262-271 conserved helix-loop-helix ubiquitous kinase Mus musculus 98-105 35546047-7 2022 Cyn treatment reduced hind paw swelling and M1 macrophage infiltration, suppressed the mRNA expression of inflammatory factors, and inhibited NLRP3 inflammasome activation in vivo, in addition to inhibiting the phosphorylation of IKKa/beta, p65, and c-Jun NH 2-terminal kinase (JNK). cynarine 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 230-239 35280366-10 2022 Results: IKKalpha and LC3B II/I expression levels were increased both in OGD/R treated N2A cells and dMCAO mice. dmcao 101-106 conserved helix-loop-helix ubiquitous kinase Mus musculus 9-17 35280366-12 2022 IKKalpha siRNA significantly decreased the infarct volume and the apparent diffusion coefficient (ADC) related to brain edema, and promoted the neurological outcomes after dMCAO. dmcao 172-177 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-8 35163299-8 2022 Additionally, we have found that apigenin, a flavonoid with anti-cancer properties, inhibits the expression of IKKalpha and attenuates most of the pro-tumoral EMT changes induced by IKKalpha in mouse tumor keratinocytes. Apigenin 33-41 conserved helix-loop-helix ubiquitous kinase Mus musculus 111-119 35163299-8 2022 Additionally, we have found that apigenin, a flavonoid with anti-cancer properties, inhibits the expression of IKKalpha and attenuates most of the pro-tumoral EMT changes induced by IKKalpha in mouse tumor keratinocytes. Apigenin 33-41 conserved helix-loop-helix ubiquitous kinase Mus musculus 182-190 35163299-9 2022 Nevertheless, we have found that apigenin only inhibits the expression of the IKKalpha protein when it is localized in the cytoplasm. Apigenin 33-41 conserved helix-loop-helix ubiquitous kinase Mus musculus 78-86 33510636-8 2020 Consistently, KS23 decreased the expression of TNF-alpha and IL-6 in the supernatant of LPS-stimulated RAW 264.7 cells and inhibited the LPS-induced nuclear translocation of NF-kappaB p65 and the phosphorylation of IKKalpha/beta/IkappaBalpha/NF-kappaB. ks23 14-18 conserved helix-loop-helix ubiquitous kinase Mus musculus 215-228 33961837-7 2021 The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor. Bilirubin 16-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-82 33864813-11 2021 We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway. 14,15-epoxy-5,8,11-eicosatrienoic acid 17-26 conserved helix-loop-helix ubiquitous kinase Mus musculus 155-168 33864813-11 2021 We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway. Palmitic Acid 115-128 conserved helix-loop-helix ubiquitous kinase Mus musculus 155-168 33555623-8 2021 Western blot analysis exhibited TAK1-IKKalpha mediated NFkappaB pathway is also hindered by kaempferol treatment as previously reported in activated T cells. kaempferol 92-102 conserved helix-loop-helix ubiquitous kinase Mus musculus 37-45 33561444-7 2021 According to the in silico predictions, p-coumaric acid reached stable interactions with both the ATP-binding site of IKKbeta as well as the regions within LFA-1, critical for interaction with ICAM-1, thereby suppressing the production of proinflammatory mediators and hindering the neutrophil infiltration, respectively. p-coumaric acid 40-55 conserved helix-loop-helix ubiquitous kinase Mus musculus 118-125 33561444-7 2021 According to the in silico predictions, p-coumaric acid reached stable interactions with both the ATP-binding site of IKKbeta as well as the regions within LFA-1, critical for interaction with ICAM-1, thereby suppressing the production of proinflammatory mediators and hindering the neutrophil infiltration, respectively. Adenosine Triphosphate 98-101 conserved helix-loop-helix ubiquitous kinase Mus musculus 118-125 33860440-10 2021 While inhibiting mTOR by rapamycin or shmTOR significantly suppressed high glucose-induced activation of NF-kappaB and its regulators IKKbeta and IkappaBalpha, suggesting mTOR is the upstream regulator of NF-kappaB. Glucose 75-82 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-141 33864813-11 2021 We observed that 14,15-EET or sEH knock-down or inhibition prevented the upregulation of SGLT2 upon treatment with palmitic acid or NaCl by inhibiting the IKKalpha/beta/NF-kappaB signaling pathway. Sodium Chloride 132-136 conserved helix-loop-helix ubiquitous kinase Mus musculus 155-168 33864813-13 2021 The increased urine excretion of glucose and sodium was mediated by decreased renal SGLT2 expression due to inactivation of the IKKalpha/beta/NF-kappaB-induced inflammatory response. Glucose 33-40 conserved helix-loop-helix ubiquitous kinase Mus musculus 128-141 33864813-13 2021 The increased urine excretion of glucose and sodium was mediated by decreased renal SGLT2 expression due to inactivation of the IKKalpha/beta/NF-kappaB-induced inflammatory response. Sodium 45-51 conserved helix-loop-helix ubiquitous kinase Mus musculus 128-141 33714889-11 2021 INTERPRETATION: Decreased miR-214-3p activates the NF-kappaB signaling pathway and aggravates OA development through targeting IKKbeta, suggesting miR-214-3p may be a novel therapeutic target for OA. mir-214-3p 26-36 conserved helix-loop-helix ubiquitous kinase Mus musculus 127-134 33714889-11 2021 INTERPRETATION: Decreased miR-214-3p activates the NF-kappaB signaling pathway and aggravates OA development through targeting IKKbeta, suggesting miR-214-3p may be a novel therapeutic target for OA. mir-214-3p 147-157 conserved helix-loop-helix ubiquitous kinase Mus musculus 127-134 33527006-5 2021 Herein, we identified a naturally derived small molecule NDSM253 that specifically inhibited IKKalpha (Inhibitor of NF-kappaB kinase subunit-alpha), a critical component of TLR4/NF-kappaB signaling. ndsm253 57-64 conserved helix-loop-helix ubiquitous kinase Mus musculus 93-101 33527006-8 2021 Administration of these IKK inhibitors in a mouse femoral fracture model showed that NDSM253 suppressed proinflammatory cytokine genes, thereby promoting bone healing, while the other three IKK inhibitors showed a weaker improvement of both bone healing and circulating proinflammatory cytokines. ndsm253 85-92 conserved helix-loop-helix ubiquitous kinase Mus musculus 24-27 33527006-9 2021 Collectively, our data suggested that NDSM253 might be an effective inhibitor of IKKalpha that could inhibit inflammatory cytokine action in bone injury. ndsm253 38-45 conserved helix-loop-helix ubiquitous kinase Mus musculus 81-89 33523871-4 2021 In this study, we found that IKKbeta ubiquitination on lysine-238 was substantially increased during inflammation. Lysine 55-61 conserved helix-loop-helix ubiquitous kinase Mus musculus 29-36 33069779-10 2021 CONCLUSION: In conclusion, IKKbeta, modulated by DJ-1p-VHL, reduces p-Tau accumulation via autophagy in AD"s disease model. p-tau 68-73 conserved helix-loop-helix ubiquitous kinase Mus musculus 27-34 33577041-14 2021 Cell transfection experiments revealed that pcDNA-TLR7 group and Triptolide group had increased TLR7 expression while decreased p-IKKalpha and NF-kappaBp65, decreased proliferation level, and increased cell apoptosis (all p<0.05); while the contrary results were found in siRNA-TLR7 group and Asatone group (all p<0.05); yet without significant difference in pcDNA-TLR7+Asatone group (all p>0.05). triptolide 65-75 conserved helix-loop-helix ubiquitous kinase Mus musculus 130-138 32761488-8 2021 In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin. dioscin 160-167 conserved helix-loop-helix ubiquitous kinase Mus musculus 79-86 33303821-0 2020 Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKbeta and mTORC1. Fatty Acids 0-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 111-118 33456673-12 2020 In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid. alanylglutamine 30-45 conserved helix-loop-helix ubiquitous kinase Mus musculus 175-182 33456673-12 2020 In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid. alanylglutamine 30-45 conserved helix-loop-helix ubiquitous kinase Mus musculus 183-190 33303821-7 2020 Our results demonstrate that saturated FFA activated the serine/threonine kinases IkappaB kinase (IKK)beta/IkappaBalpha and mTORC1/S6K1, but not protein kinase C and c-jun N-terminal kinase, in podocytes and glomeruli of db/db mice. Serine 57-63 conserved helix-loop-helix ubiquitous kinase Mus musculus 98-106 33084638-0 2020 Anti-inflammatory and analgesic activities of indigo through regulating the IKKbeta/IkappaB/NF-kappaB pathway in mice. Indigo Carmine 46-52 conserved helix-loop-helix ubiquitous kinase Mus musculus 76-83 32617861-0 2020 Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKbeta/NF-kappaB Signaling Pathway. rhoifolin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 105-112 33084638-9 2020 In conclusion, indigo exerts significant anti-inflammatory and analgesic activities in mice by inhibiting IKKbeta phosphorylation and reducing the production of important pain mediators, such as PGE2 and COX-2, via the IKKbeta/IkappaB/NF-kappaB pathway. Indigo Carmine 15-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 106-113 33084638-9 2020 In conclusion, indigo exerts significant anti-inflammatory and analgesic activities in mice by inhibiting IKKbeta phosphorylation and reducing the production of important pain mediators, such as PGE2 and COX-2, via the IKKbeta/IkappaB/NF-kappaB pathway. Indigo Carmine 15-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 219-226 32761008-6 2020 A transwell assay in vitro and an immunofluorescence assay in Hepa1-6 tumor-bearing mice indicated that CDMPR exhibited a pH-sensitive disassembly ability in tumor tissue, IKKbeta-siRNA was precisely delivered to M2-type TAMs and DOX was internalized into tumor cells. tams 221-225 conserved helix-loop-helix ubiquitous kinase Mus musculus 172-179 32932805-6 2020 Furthermore, diminished activation and nuclear translocation of NF-kappaB were found after quercetin treatment through inhibiting IKKalpha and Ikappabalpha phosphorylation of intensive running mice. Quercetin 91-100 conserved helix-loop-helix ubiquitous kinase Mus musculus 130-138 32761008-8 2020 In Hepa1-6 tumor-bearing mice, CDMPR exhibited improved antitumor efficiency with M2-type re-polarization ability by the precise delivery of IKKbeta-siRNA and DOX to M2-type TAMs and tumor cells, respectively. tams 174-178 conserved helix-loop-helix ubiquitous kinase Mus musculus 141-148 32761008-6 2020 A transwell assay in vitro and an immunofluorescence assay in Hepa1-6 tumor-bearing mice indicated that CDMPR exhibited a pH-sensitive disassembly ability in tumor tissue, IKKbeta-siRNA was precisely delivered to M2-type TAMs and DOX was internalized into tumor cells. Doxorubicin 230-233 conserved helix-loop-helix ubiquitous kinase Mus musculus 172-179 32020377-0 2020 Suppression of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma through IKKbeta inhibition. Cisplatin 54-63 conserved helix-loop-helix ubiquitous kinase Mus musculus 120-127 32446381-0 2020 Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKbeta stimulated LOX production. triptolide 0-10 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-81 32004628-12 2020 Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha. vitexin 0-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 191-199 32004628-13 2020 Trolline significantly down-regulated the protein expression of TLR7 whereas significantly up-regulated the protein expression of TLR4, IKKalpha and TAK1. trolline 0-8 conserved helix-loop-helix ubiquitous kinase Mus musculus 136-144 32378169-11 2020 There was decline of IKK-beta and NF-kappaB-P65 and elevation of IkappaB-alpha in the N-acetylcysteine group, which was even significantly in the Budesonide group (P < 0.01). Acetylcysteine 86-102 conserved helix-loop-helix ubiquitous kinase Mus musculus 21-29 32378169-11 2020 There was decline of IKK-beta and NF-kappaB-P65 and elevation of IkappaB-alpha in the N-acetylcysteine group, which was even significantly in the Budesonide group (P < 0.01). Budesonide 146-156 conserved helix-loop-helix ubiquitous kinase Mus musculus 21-29 32237724-7 2020 The inhibition of these pathways by BA was once more confirmed by retrovirus infection of constitutively active (CA)-Akt and CA-Ikkbeta retrovirus and measurement of Ca2+ influx. betulinic acid 36-38 conserved helix-loop-helix ubiquitous kinase Mus musculus 128-135 32442901-9 2020 Further, NF-kappaB activation was also blocked by attenuating the phosphorylation of IkB kinase (IKK alpha/beta) in DSS-induced colitis tissues. dss 116-119 conserved helix-loop-helix ubiquitous kinase Mus musculus 97-111 32640590-6 2020 LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65. Reactive Oxygen Species 22-45 conserved helix-loop-helix ubiquitous kinase Mus musculus 129-142 32640590-6 2020 LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65. Serine 70-76 conserved helix-loop-helix ubiquitous kinase Mus musculus 129-142 32640590-8 2020 Consequently, DAC reduced the phosphorylation of IKKalpha/beta to block the nuclear localization of p65, which decreased NF-kappaB activation. dauricine 14-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 49-62 32448281-12 2020 Intriguingly, DHT could upregulate nuclear expression of TFEB and reduce expressions of p-IKKalpha/beta and p-NF-kappaB. Dihydrotestosterone 14-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 90-103 32020377-1 2020 We explored the role of the transcription factor, NF-kappaB, and its upstream kinase IKKbeta in regulation of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma (HNSCC). Cisplatin 149-158 conserved helix-loop-helix ubiquitous kinase Mus musculus 85-92 32020377-2 2020 We showed that cisplatin-resistant HNSCC cells have a stronger ability to migrate and invade, as well as display higher IKKbeta/NF-kappaB activity compared to their parental partners. Cisplatin 15-24 conserved helix-loop-helix ubiquitous kinase Mus musculus 120-127 32020377-8 2020 Our data demonstrated the crucial role of IKKbeta in control of migration, invasion, and metastasis, and implicated that targeting IKKbeta may be a potential therapy for cisplatin-resistant metastatic HNSCC. Cisplatin 170-179 conserved helix-loop-helix ubiquitous kinase Mus musculus 131-138 31866511-8 2020 Molecular docking and molecular dynamic (MD) simulation assay were performed to verify the binding between Arg and IKKalpha/IKKbeta. arenobufagin 107-110 conserved helix-loop-helix ubiquitous kinase Mus musculus 115-123 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. Adenosine Triphosphate 26-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 48-56 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. Adenosine Triphosphate 26-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 274-282 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 48-56 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 147-150 conserved helix-loop-helix ubiquitous kinase Mus musculus 48-56 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 274-282 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 147-150 conserved helix-loop-helix ubiquitous kinase Mus musculus 274-282 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. Adenosine Triphosphate 166-169 conserved helix-loop-helix ubiquitous kinase Mus musculus 48-56 32042747-11 2019 Results: In vitro, we observed that GENT reduced the inflammatory cytokine production of BMMs stimulated by (LPS)/IFN-gamma and ameliorated the phosphorylation of IKKalpha/beta and p65, the degradation of IkappaBalpha, and the translocation of p65 into the nucleus. gentiopicroside 36-40 conserved helix-loop-helix ubiquitous kinase Mus musculus 163-176 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. Adenosine Triphosphate 166-169 conserved helix-loop-helix ubiquitous kinase Mus musculus 274-282 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 147-150 conserved helix-loop-helix ubiquitous kinase Mus musculus 48-56 31866511-14 2020 Arg could be bound in the ATP binding pocket of IKKalpha and IKKbeta by molecular docking assay, and MD simulation assay further demonstrated that Arg binding to the ATP-binding pocket of IKKbeta was very stable in 300 ns MD simulation, compared with the binding of Arg and IKKalpha. arenobufagin 147-150 conserved helix-loop-helix ubiquitous kinase Mus musculus 274-282 31618665-12 2020 Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression. pifithrin 32-40 conserved helix-loop-helix ubiquitous kinase Mus musculus 80-87 31618665-12 2020 Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression. triptolide 51-53 conserved helix-loop-helix ubiquitous kinase Mus musculus 80-87 31792060-3 2019 In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context. Tamoxifen 76-85 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-52 31792060-3 2019 In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context. Tamoxifen 87-90 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-52 31792060-3 2019 In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context. Tamoxifen 87-90 conserved helix-loop-helix ubiquitous kinase Mus musculus 150-158 31792060-3 2019 In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context. Urethane 250-258 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-52 31792060-3 2019 In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKalpha loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-beta instead acts as a tumor promoter in this same context. Urethane 250-258 conserved helix-loop-helix ubiquitous kinase Mus musculus 150-158 31618063-5 2019 Therefore, we hypothesized that IKKbeta-dependent NF-kappaB activation in monocytes and macrophages plays a role in IHH-induced PA atherosclerosis. ihh 116-119 conserved helix-loop-helix ubiquitous kinase Mus musculus 32-39 31618063-11 2019 Our findings demonstrate that IKKbeta-dependent NF-kappaB activity in myeloid-lineage cells plays a critical role in IHH-induced PA atherosclerosis at the early stage. ihh 117-120 conserved helix-loop-helix ubiquitous kinase Mus musculus 30-37 31479750-2 2019 In the current study, we identified a novel IKKbeta inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis. ellipticine 63-74 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-51 31744501-11 2019 DOX also caused the increase in the expression of IKK-alpha and iNOS and produced a large amount of NO, resulting in the accumulation of nitrotyrosine in the heart tissue. Doxorubicin 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 50-59 31744501-13 2019 CONCLUSIONS: SMI could recover inflammatory cytokine levels and suppress the expression of IKK-alpha and iNOS in vivo, which was increased by DOX. Doxorubicin 142-145 conserved helix-loop-helix ubiquitous kinase Mus musculus 91-100 31781591-9 2019 Moreover, DSS-induced elevation of phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and NF-kappaB (p65) was remarkably blunted by dihydroartemisinin both in vivo and in vitro, indicating an inhibitive property on the PI3K/AKT and NF-kappaB signaling pathways. artenimol 135-153 conserved helix-loop-helix ubiquitous kinase Mus musculus 65-73 31827674-8 2019 Moreover, aloin inhibited hepatocyte apoptosis and inflammatory response that was caused by the upregulated expression of Bcl-2, the downregulated expression of cleaved caspase3(C-caspase3), Bax, Toll-like receptor 4 (TLR4), FADD, MyD88, TRAF6, phosphorylated IKKalpha/beta (p-IKKalpha/beta), and phosphorylated nuclear factor kappaB p65 (p-NF-kappaB p65). alloin 10-15 conserved helix-loop-helix ubiquitous kinase Mus musculus 260-273 31479750-2 2019 In the current study, we identified a novel IKKbeta inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis. ellipticine 76-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-51 31479750-8 2019 The results demonstrated that the inhibitory effect of ELL on IKKbeta activity was impaired in the mutation, implying that anti-inflammatory effect of ELL was partially attributed to binding on cysteine 46. Cysteine 194-202 conserved helix-loop-helix ubiquitous kinase Mus musculus 62-69 31506437-3 2019 IMD 0354 is a selective molecular inhibitor of inhibitor of NF-kappaB kinase subunit beta (IKKbeta) and effective for treatment of acute and subacute inflammatory diseases through the suppression of NF-kappaB activation. N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 0-8 conserved helix-loop-helix ubiquitous kinase Mus musculus 91-98 30937840-7 2019 Moreover, we found that tizoxanide inhibited the phosphorylation of IKK-alpha and degradation of IkappaB by LPS in macrophage cells. tizoxanide 24-34 conserved helix-loop-helix ubiquitous kinase Mus musculus 68-77 31552024-8 2019 IKKbeta-deficient mice also had distinct differences in colonic tissue-associated and luminal microbiome that may confer protection against C. rodentium. Phenobarbital 86-93 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-7 31088970-4 2019 In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion. Serine 44-50 conserved helix-loop-helix ubiquitous kinase Mus musculus 17-24 30951845-10 2019 Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells. cs-me 24-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 124-137 31222033-4 2019 To this end, we induced specific IKKalpha knockout in adult chondrocytes in AcanCreERT2/+; IKKalphaf/f mice treated with tamoxifen (cKO). Tamoxifen 121-130 conserved helix-loop-helix ubiquitous kinase Mus musculus 33-41 31222033-4 2019 To this end, we induced specific IKKalpha knockout in adult chondrocytes in AcanCreERT2/+; IKKalphaf/f mice treated with tamoxifen (cKO). CKO 132-135 conserved helix-loop-helix ubiquitous kinase Mus musculus 33-41 31222033-8 2019 Interestingly, in spite of the protection from structural articular cartilage damage, the postnatal growth plates of IKKalpha cKO mice after DMM displayed abnormal architecture and composition associated with increased chondrocyte apoptosis, which were not as evident in the articular chondrocytes of the same animals. dimethylmyleran 141-144 conserved helix-loop-helix ubiquitous kinase Mus musculus 117-125 31088970-4 2019 In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion. Serine 52-53 conserved helix-loop-helix ubiquitous kinase Mus musculus 17-24 31088970-4 2019 In cell culture, IKKbeta phosphorylates HTT serine (S) 13 and activates HTT degradation, a process that becomes impaired with polyQ expansion. polyglutamine 126-131 conserved helix-loop-helix ubiquitous kinase Mus musculus 17-24 31088970-5 2019 To investigate the in vivo relationship of IKKbeta to HTT S13 phosphorylation and HD progression, we crossed conditional tamoxifen-inducible IKKbeta knockout mice with R6/1 HD mice. Tamoxifen 121-130 conserved helix-loop-helix ubiquitous kinase Mus musculus 141-148 30858802-9 2019 In vivo, vildagliptin suppressed the expressions of PCNA and alpha-SMA, phospho-p65, phospho-IKKalpha/beta, GRP78 and CHOP, as well as IRE-1 in vascular smooth muscle cells (VSMCs). Vildagliptin 9-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 93-101 30856390-8 2019 IMX treatment promotes the inhibitory phosphorylation of GSK-3beta at Ser9 and moreover, a marked reduction in the phosphorylation of IKK-beta, which prevents translocation and activation of NF-kappaB. indirubin-3'-monoxime 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-142 31105857-7 2019 In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway. Vitamin D 221-230 conserved helix-loop-helix ubiquitous kinase Mus musculus 60-80 30740911-0 2019 Isoalantolactone inhibits IKKbeta kinase activity to interrupt the NF-kappaB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma. isoalantolactone 0-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 26-33 30214937-7 2018 IKKbeta (inhibitor of nuclear factor kappaB kinase beta)-mediated RORgammat Ser489 phosphorylation induced the AhR-RORgammat interaction. rorgammat 66-75 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-7 30746687-8 2019 In the further mechanism studies, we found that the anti-inflammatory effect of myricetin was mediated by inhibiting LPS-induced phosphorylation of AKT, IKK-alpha, IkappaB-alpha, and P65 in vivo and in vitro. myricetin 80-89 conserved helix-loop-helix ubiquitous kinase Mus musculus 153-162 30359174-6 2019 Metformin reduced levels of the NFkappaB signaling components p-IKKalpha/beta, p-NFkappaB, p-IkappaBalpha in colorectal mucosal cells. Metformin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 64-77 31679314-10 2019 Finally, we found that D-pinitol reserved the TRAF3, NIK, IKKalpha, and RelB in the psoriatic skin, signifying that it restrains the commencement of NF-kappaB signaling pathways. pinitol 23-32 conserved helix-loop-helix ubiquitous kinase Mus musculus 58-66 30223923-9 2018 Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells. Trifluoroacetic Acid 30-33 conserved helix-loop-helix ubiquitous kinase Mus musculus 146-159 30258447-11 2018 Finally, we found that esculetin inhibited the phosphorylation of IKKalpha and P65 in the psoriatic skin, suggesting that it inhibits the activation of NF-kappaB signaling. esculetin 23-32 conserved helix-loop-helix ubiquitous kinase Mus musculus 66-74 30618760-9 2018 Pretreatment with costunolide could reduce the expression of toll-like receptor 4, myeloid differentiation factor 88, p65 (Nucleus), phosphorylated IkappaB kinase alpha/beta, inhibitor of nuclear factor kappa-B kinase, inhibitor kappa Balpha and prevent the expression of phosphorylated inhibitor kappa B kinase which repressed translocation of p65 from cytoplasm to nucleus. costunolide 18-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 148-241 30598682-6 2018 Moreover, Ac-ME was shown to inhibit the NF-kappaB pathway, according to the luciferase reporter gene assay performed with a NF-kappaB-Luc construct containing NF-kappaB-binding promoter regions under MyD88 and TRIF overexpression conditions, and immunoblotting analysis by determining the phospho-form levels of IkappaBalpha, IKKalpha/beta, and p85, a regulatory domain of phosphatidylinositide 3-kinase (PI3K). ac-me 10-15 conserved helix-loop-helix ubiquitous kinase Mus musculus 327-340 29644554-5 2018 The anti-inflammatory effect of curcumin was associated with the repression of phosphorylation of IKKalpha-IKKbeta, and JNK. Curcumin 32-40 conserved helix-loop-helix ubiquitous kinase Mus musculus 98-123 30214937-7 2018 IKKbeta (inhibitor of nuclear factor kappaB kinase beta)-mediated RORgammat Ser489 phosphorylation induced the AhR-RORgammat interaction. rorgammat 115-124 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-7 29374854-9 2018 RESULTS: PA elevated not only phosphorylation of JNK, IRS1 serines, and IKKalpha/beta, but also the expression of IL-6, TNFalpha and IL-1beta in C2C12-GLUT4myc cells. Palmitic Acid 9-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 72-85 29532887-10 2018 Additionally, juglanin markedly downregulated inflammatory cytokine secretion and phosphorylated nuclear factor-kappaB (NF-kappaB) expression via inhibiting IKKalpha/IkappaBalpha signaling pathway. juglanin 14-22 conserved helix-loop-helix ubiquitous kinase Mus musculus 157-165 28842306-7 2017 In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway as the phosphorylated proteins of NF-kappaB, IkappaB kinase (IKK)alpha and IKKbeta in the hippocampus were suppressed after berberine administration. Berberine 21-30 conserved helix-loop-helix ubiquitous kinase Mus musculus 189-214 28761990-3 2017 Meanwhile, phosphorylation of inhibitor of kappaBalpha (IkappaBalpha) and IkappaB kinase alpha/beta (IKKalpha/beta), as well as translocation of nuclear factor-kappaB (NF-kappaB) to the nucleus, was suppressed by roburic acid treatment. Roburic acid 213-225 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-114 29311298-5 2018 In mice, lung-specific Ikkalpha ablation (IkkalphaDeltaLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation. Reactive Oxygen Species 210-233 conserved helix-loop-helix ubiquitous kinase Mus musculus 23-31 29311298-5 2018 In mice, lung-specific Ikkalpha ablation (IkkalphaDeltaLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation. Reactive Oxygen Species 235-238 conserved helix-loop-helix ubiquitous kinase Mus musculus 23-31 29129664-5 2018 HsA inhibited phosphorylation of IKKalpha/beta and degradation of IkappaBalpha, resulting in decreased nuclear translocation of nuclear factor-kappaB (NF-kappaB) and its transcriptional activity. hemistepsin 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 33-46 28472283-7 2017 Specifically, we identified that RhoA/ROCK activated IkappaB kinase alpha, which promoted the phosphorylation of p65 on serine 536 (p65 pS536). Serine 120-126 conserved helix-loop-helix ubiquitous kinase Mus musculus 53-73 28059488-7 2017 Importantly, pre-treatment of the cells with resveratrol completely abrogated the phosphorylation of ERK1/2, JNK, and IKKalpha/IKKbeta in palmitate treated cells. Resveratrol 45-56 conserved helix-loop-helix ubiquitous kinase Mus musculus 118-126 27836674-2 2017 The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKalpha kinase activity, has been observed in vitro. N-acetylphenylalanine 15-37 conserved helix-loop-helix ubiquitous kinase Mus musculus 145-153 28577436-5 2017 In addition, UAA effectively reduced the expression and production of inflammatory mediators, including cytokines and matrix metalloproteinase-1/3 in the knee joint tissue and RA synovial fibroblasts, through the downregulation of IKKalpha/beta, IotakappaBalpha, and nuclear factor-kappaB. 6-Carboxymethyluracil 13-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 231-288 28603455-9 2017 In isolated microglia, TMP attenuated the effects of lipopolysaccharide on the phosphorylation of cytoplasmic IKKalpha/beta and IKB-alpha, and levels of nucleic p65. tetramethylpyrazine 23-26 conserved helix-loop-helix ubiquitous kinase Mus musculus 110-123 28208071-0 2017 Anthocyanin suppresses CoCrMo particle-induced osteolysis by inhibiting IKKalpha/beta mediated NF-kappaB signaling in a mouse calvarial model. Anthocyanins 0-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 72-85 28208071-9 2017 Furthermore, we confirmed that anthocyanin attenuated osteolysis by blocking NF-kappaB pathway via inhibiting inhibitor of nuclear factor kappa-B kinase alpha/beta (IKKalpha/beta) phosphorylation. Anthocyanins 31-42 conserved helix-loop-helix ubiquitous kinase Mus musculus 138-178 28208071-10 2017 In conclusion, our study demonstrated that anthocyanin can protect against CoCrMo particle-induced inflammatory osteolysis via inhibiting the IKKalpha/beta-NF-kappaB pathway, and have a potential therapeutic effect on the treatment of wear particle-induced osteolysis. Anthocyanins 43-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 142-150 27836674-2 2017 The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKalpha kinase activity, has been observed in vitro. Acecainide 50-54 conserved helix-loop-helix ubiquitous kinase Mus musculus 145-153 27836674-6 2017 RESULTS: The injection of NAPA significantly improved cartilage thickness (CT) and reduced Chambers and Mankin modified scores and fibrillation index (FI), with weaker MMP13, ADAMTS5, MMP10 and IKKalpha staining. Acecainide 26-30 conserved helix-loop-helix ubiquitous kinase Mus musculus 194-202 27836674-8 2017 CONCLUSIONS: NAPA markedly improved the physical structure of articular cartilage while reducing catabolic enzymes, extracellular matrix (ECM) remodeling and IKKalpha expression, showing to be able to exert a chondroprotective activity in vivo. Acecainide 13-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 158-166 27144271-10 2016 Pre-treatment with paeonol significantly inhibited IKKalpha/beta, IkappaBalpha and p65 phosphorylation which contributed to ameliorating APAP-induced hepatic inflammation. paeonol 19-26 conserved helix-loop-helix ubiquitous kinase Mus musculus 51-64 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Melatonin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 89-97 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Fluorouracil 30-34 conserved helix-loop-helix ubiquitous kinase Mus musculus 89-97 28178289-11 2017 Eupatilin suppressed NF-kappaB signaling activities in ischemic brain by reducing IKKalpha/beta phosphorylation, IkappaBalpha phosphorylation, and IkappaBalpha degradation. eupatilin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 82-90 28039475-6 2017 Moreover, in the DHA-treated mice, enhanced expression and improved distribution integrity of protein GPR120 were observed, which was probably associated with the regulation of TAK1/IKK-alpha/IkB-alpha/p65 pathway. Docosahexaenoic Acids 17-20 conserved helix-loop-helix ubiquitous kinase Mus musculus 182-191 26931732-5 2016 Furthermore, molecular mechanism studies indicated that alpha-solanine inhibited LPS-induced activation of nuclear factor-kappaB (NF-kappaB) by reducing nuclear translocation of p65, degradation of inhibitory kappaBalpha (IkappaBalpha), and phosphorylation of IkappaB kinasealpha/beta (IKKalpha/beta). alpha-solanine 56-70 conserved helix-loop-helix ubiquitous kinase Mus musculus 260-299 29441925-6 2016 We also examined the acetylpuerarin"s effect on the activity of PKC-delta, IKKbeta and caspase-8/caspase-3 pathway. acetylpuerarin 21-35 conserved helix-loop-helix ubiquitous kinase Mus musculus 75-82 26848161-5 2016 Moreover, IKKalpha null macrophages treated with lipotoxic palmitic acid exhibited early exhaustion of Akt signaling compared with wild-type cells. Palmitic Acid 59-72 conserved helix-loop-helix ubiquitous kinase Mus musculus 10-18 27093924-2 2016 The plant hormone osmotin inhibited lipopolysaccharide (LPS)-induced TLR4 downstream signaling, including activation of TLR4, CD14, IKKalpha/beta, and NFkappaB, and the release of inflammatory mediators, such as COX-2, TNF-alpha, iNOS, and IL-1beta. osmotin 18-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 132-145 27002412-13 2016 Treatment of the RAW cells with aloin suppressed RANKL-induced NF-kappaB pathway components like IKKalpha, IKKbeta, Phospho.IKK alpha/beta, NF-kappaB-p65, Phospho NF-kappaB-p65 and IkappaBalpha. alloin 32-37 conserved helix-loop-helix ubiquitous kinase Mus musculus 97-105 26476923-4 2016 Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages. Dexamethasone 5-18 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-141 26476923-4 2016 Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages. Quercetin 23-32 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-141 24519526-0 2014 The Ah receptor recruits IKKalpha to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Serine 80-86 conserved helix-loop-helix ubiquitous kinase Mus musculus 25-33 26490221-12 2015 GTS-21 also suppressed LPS-induced phosphorylation of NF-kappaBp65, IKKalpha/beta, IkappaBalpha, and Akt, as well as NF-kappaB p65 nuclear translocation. 3-(2,4-dimethoxybenzylidene)anabaseine 0-6 conserved helix-loop-helix ubiquitous kinase Mus musculus 68-81 25749152-5 2015 reduced blood glucose levels significantly and increased the protein expressions of insulin receptor beta, insulin receptor substrate 1, protein kinase B (Akt/PKB), IKKalpha, and IkappaBalpha. Glucose 14-21 conserved helix-loop-helix ubiquitous kinase Mus musculus 165-173 25519833-8 2015 Furthermore, bornyl cinnamate significantly blocked the lipopolysaccharide-induced activation of I-kappaB kinase alpha, an upstream kinase of the inhibitor of nuclear factor kappaB alpha. bornyl cinnamate 13-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 97-118 24886817-6 2014 Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF. Bleomycin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 46-54 24886817-6 2014 Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF. Bleomycin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 71-79 24886817-6 2014 Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF. Bleomycin 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 71-79 26285901-4 2015 Mechanistic studies show that MLB counteracts Abeta (1-42)-induced activation of the nuclear factor kappa B (NF-kappaB) pathway, evidenced by the suppression of NF-kappaB luciferase reporters, decreased expression of phosphorylated Inhibitor kappaB alpha and IkappaB kinase alpha, and reduced nuclear translocation of p65 in response to pre-treatment with 50 mug/ml MLB prior to Abeta (1-42) exposure. UNII-042A8N37WH 46-51 conserved helix-loop-helix ubiquitous kinase Mus musculus 259-279 25401971-10 2015 Furthermore, Western blot and morphological results showed that melatonin treatment significantly reduced D-galactose-induced neuroinflammation through inhibition of microgliosis (Iba-1) and astrocytosis (GFAP), and downregulating other inflammatory mediators such as p-IKKbeta, p-NF-K B65, COX2, NOS2, IL-1beta, and TNFalpha. Melatonin 64-73 conserved helix-loop-helix ubiquitous kinase Mus musculus 270-277 25401971-10 2015 Furthermore, Western blot and morphological results showed that melatonin treatment significantly reduced D-galactose-induced neuroinflammation through inhibition of microgliosis (Iba-1) and astrocytosis (GFAP), and downregulating other inflammatory mediators such as p-IKKbeta, p-NF-K B65, COX2, NOS2, IL-1beta, and TNFalpha. Galactose 106-117 conserved helix-loop-helix ubiquitous kinase Mus musculus 270-277 24999035-9 2014 MiR-223 was inversely upregulated in IBE-treated cells; overexpression of miR-223 decreased the expression of miR-27b by suppressing IKKalpha expression. ibe 37-40 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-141 24498990-0 2014 A novel IKKalpha inhibitor, noraristeromycin, blocks the chronic inflammation associated with collagen-induced arthritis in mice. 5'-noraristeromycin 28-44 conserved helix-loop-helix ubiquitous kinase Mus musculus 8-16 24498990-1 2014 OBJECTIVES: To evaluate the therapeutic efficacy of a novel inhibitor for IkappaB kinase alpha (IKKalpha), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). 5'-noraristeromycin 107-123 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-94 24498990-1 2014 OBJECTIVES: To evaluate the therapeutic efficacy of a novel inhibitor for IkappaB kinase alpha (IKKalpha), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). 5'-noraristeromycin 107-123 conserved helix-loop-helix ubiquitous kinase Mus musculus 96-104 24519526-6 2014 Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells. Polychlorinated Dibenzodioxins 260-264 conserved helix-loop-helix ubiquitous kinase Mus musculus 131-139 24519526-8 2014 Given the role of H3S10ph in regulation of chromosome condensation, AHR-IKKalpha cross-talk may be a mediator of chromatin remodeling by environmental agents. h3s10ph 18-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 72-80 24519526-5 2014 Using chromatin immunoprecipitation with antibodies to a comprehensive set of protein kinases, we identified three kinases, IkappaB kinase alpha (IKKalpha), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells and absent in control c35 cells. Polychlorinated Dibenzodioxins 337-341 conserved helix-loop-helix ubiquitous kinase Mus musculus 124-144 24519526-5 2014 Using chromatin immunoprecipitation with antibodies to a comprehensive set of protein kinases, we identified three kinases, IkappaB kinase alpha (IKKalpha), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly increased by TCDD in Hepa-1c1c7 cells and absent in control c35 cells. Polychlorinated Dibenzodioxins 337-341 conserved helix-loop-helix ubiquitous kinase Mus musculus 146-154 24519526-6 2014 Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells. Polychlorinated Dibenzodioxins 82-86 conserved helix-loop-helix ubiquitous kinase Mus musculus 28-36 24519526-6 2014 Complexes of AHR, ARNT, and IKKalpha could be coimmunoprecipitated from nuclei of TCDD treated Hepa-1c1c7 cells and shRNA-mediated IKKalpha knockdown inhibited both H3S10 phosphorylation in the Cyp1a1 enhancer and the induction of Cyp1a1, Aldh3a1, and Nqo1 in TCDD-treated cells. Polychlorinated Dibenzodioxins 260-264 conserved helix-loop-helix ubiquitous kinase Mus musculus 28-36 24044575-12 2013 Ex vivo incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKKalpha suppression and concomitant I-kappaB accumulation; increase of IL-6 and TGF-beta; and, decrease of TNF-alpha. epigallocatechin gallate 45-49 conserved helix-loop-helix ubiquitous kinase Mus musculus 75-83 23735482-11 2013 Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation. Quercetin 10-19 conserved helix-loop-helix ubiquitous kinase Mus musculus 211-219 24955217-5 2014 Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway. CMPDA 68-73 conserved helix-loop-helix ubiquitous kinase Mus musculus 171-179 24488495-10 2014 The phosphorylation of IKKalpha at threonine 23 and its kinase activity were indispensable for the processing of p100 and osteoclastogenesis by RelB-induced Cot. Threonine 35-44 conserved helix-loop-helix ubiquitous kinase Mus musculus 23-31 24508132-9 2014 Pre-treatment with MHY884 inhibited Akt and IkappaB kinase alpha/beta signaling pathways, leading to decreased translocation and phosphorylation of p65, a subunit of NF-kappaB. 4-(5-chloro-2,3-dihydrobenzo(d)thiazol-2-yl)-2,6-dimethoxyphenol 19-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-64 24349299-7 2013 Both western blot and luciferase activity assay showed that vinpocetine inhibited the enhanced Akt, IKKalpha/beta, IkappaBalpha phosphorylation and NF-kappaB activity induced by ox-LDL, and the inhibition of NF-kappaB activity was partly caused by Akt dephosphorylation. vinpocetine 60-71 conserved helix-loop-helix ubiquitous kinase Mus musculus 100-113 24044575-12 2013 Ex vivo incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKKalpha suppression and concomitant I-kappaB accumulation; increase of IL-6 and TGF-beta; and, decrease of TNF-alpha. tam 22-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 75-83 23503581-7 2013 Based on the inherent property of Au-NPs to bind to -thiol groups and the presence of cysteine residues on the NF-kappaB signal transduction proteins IkappaB kinases (IKK), proteins specifically bound to Au-NPs were extracted from CH12.LX cellular lysate exposed to 10 nm Au-NPs. Cysteine 86-94 conserved helix-loop-helix ubiquitous kinase Mus musculus 167-170 21656643-4 2013 Taken together, the inflammation of mice liver caused by exposure to CeCl3 might be closely associated with the alteration of inflammatory cytokine expressions in the mouse liver, the signal-transducing events happening in CeCl3-induced macrophages of liver sequentially might occur via activation of TLRs TNF-alpha NIK IkappaB kinase (including IKK1, IKK2) NF-kappaB (including NF-kappaBP52, NF-kappaBP65) inflammation. cerous chloride 69-74 conserved helix-loop-helix ubiquitous kinase Mus musculus 346-350 21656643-4 2013 Taken together, the inflammation of mice liver caused by exposure to CeCl3 might be closely associated with the alteration of inflammatory cytokine expressions in the mouse liver, the signal-transducing events happening in CeCl3-induced macrophages of liver sequentially might occur via activation of TLRs TNF-alpha NIK IkappaB kinase (including IKK1, IKK2) NF-kappaB (including NF-kappaBP52, NF-kappaBP65) inflammation. cerous chloride 223-228 conserved helix-loop-helix ubiquitous kinase Mus musculus 346-350 22595195-6 2012 Spinasterol-Glc also inhibited phosphorylation of IkappaB-alpha and IKKalpha/beta as well as translocation of NF-kappaB to the nucleus. 3-O-beta-D-glucopyranosyl-spinasterol 0-15 conserved helix-loop-helix ubiquitous kinase Mus musculus 68-81 22889356-3 2013 NCTD inhibited the proliferation of MM cells and potentiated the anti-myeloma effects of BTZ by down-regulating IKKalpha and p-IkappaBalpha, which induced the accumulation of IkappaBalpha and inhibited the constitutive activation of NF-kappaB. Bortezomib 89-92 conserved helix-loop-helix ubiquitous kinase Mus musculus 112-120 22181855-6 2012 Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB-induced (1) nuclear translocation and phosphorylation of nuclear factor kappa B/p65, (2) phosphorylation and degradation of IkappaBalpha, (3) activation of IKKalpha/IotaKappaKappabeta and (4) phosphorylation of mitogen-activated protein kinase proteins and c-Jun. Coconut Oil 54-57 conserved helix-loop-helix ubiquitous kinase Mus musculus 236-244 22542583-5 2012 Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-kappaB (NF-kappaB) p65 and p50 subunits to the nucleus by blocking IKKalpha/beta (IkappaB kinase alpha/beta) mediated degradation of IkappaBalpha. paeonol 48-55 conserved helix-loop-helix ubiquitous kinase Mus musculus 169-182 22542583-5 2012 Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-kappaB (NF-kappaB) p65 and p50 subunits to the nucleus by blocking IKKalpha/beta (IkappaB kinase alpha/beta) mediated degradation of IkappaBalpha. paeonol 48-55 conserved helix-loop-helix ubiquitous kinase Mus musculus 184-204 21696761-14 2012 At 4 h, 6 of these 22 genes (CHUK, HMGB1, HSPD1, IRAK2, LY96, and TLR4) were further 2-fold increased in the LPS pretreatment group compared with the saline pretreatment group. Sodium Chloride 150-156 conserved helix-loop-helix ubiquitous kinase Mus musculus 29-33 21585385-11 2011 Eugenosedin-A, like atorvastatin, could inhibit p38, ERK, JNK, Akt/IKKalpha/p65 proteins, as well as TNF-alpha and IFN-gamma mRNA during the regulation of the obesity-induced inflammatory process. eugenosedin-A 0-13 conserved helix-loop-helix ubiquitous kinase Mus musculus 67-75 23243426-2 2012 Activation of hepatic nuclear factor-kappa B (NF-kappaB), IkappaB kinase (IKK alpha/beta) proteins, and TNFalpha and IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes. Diethylnitrosamine 153-171 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-83 23243426-2 2012 Activation of hepatic nuclear factor-kappa B (NF-kappaB), IkappaB kinase (IKK alpha/beta) proteins, and TNFalpha and IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes. Diethylnitrosamine 174-177 conserved helix-loop-helix ubiquitous kinase Mus musculus 74-83 22427843-6 2012 With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6. ursolic acid 55-57 conserved helix-loop-helix ubiquitous kinase Mus musculus 159-167 22447251-4 2012 Western blotting revealed that SNX-2112 lead to the degradation of Hsp90 client proteins including Akt, IKKalpha, NF-kappaB, B-Raf and GSK3beta. SNX 2112 31-39 conserved helix-loop-helix ubiquitous kinase Mus musculus 116-124 22340218-9 2011 However, IKKalpha expression was increased after metformin treatment in both tissues. Metformin 49-58 conserved helix-loop-helix ubiquitous kinase Mus musculus 9-17 20671747-4 2011 3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis. 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 178-186 21356367-5 2011 BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor kappaB, IkappaB-kinase alpha/beta, cAMP response element binding and the expression of caspase-3 and Ki-67. caryophyllene 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 113-133 21420465-8 2011 In addition, Cd markedly increased NF-kappaB nuclear translocation in association with IKKalpha/beta phosphorylation and IkappaBalpha degradation. Cadmium 13-15 conserved helix-loop-helix ubiquitous kinase Mus musculus 87-95 20671747-4 2011 3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis. 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid 0-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 262-270 20671747-4 2011 3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis. 3-cl 0-4 conserved helix-loop-helix ubiquitous kinase Mus musculus 262-270 20671747-4 2011 3-Cl-AHPC-mediated activation of the NF-kappaB canonical pathway occurred within 6 h, whereas maximal activation of the NF-kappaB noncanonical pathway required 48 h. Knockout of IKKalpha or IKKbeta expression in mouse embryonic fibroblast cells and knockdown of IKKalpha or IKKbeta in MDA-MB-468 cells resulted in the inhibition of 3-Cl-AHPC-mediated apoptosis, indicating that activation of canonical and noncanonical pathways are required for maximal 3-Cl-AHPC-mediated apoptosis. ahpc 5-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 178-186 20472709-9 2010 Thus, targeted disruption of Glrx1 regulates the lung proinflammatory response via histone acetylation specifically by activation of IKKalpha in response to CS exposure. Cesium 157-159 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-141 22140508-5 2011 DHA pretreatment also attenuated UVB-induced DNA binding of nuclear factor-kappaB (NF-kappaB) through the inhibition of phosphorylation of IkappaB kinase-alpha/beta, phosphorylation and degradation of IkappaBalpha and nuclear translocation of p50 and p65. Docosahexaenoic Acids 0-3 conserved helix-loop-helix ubiquitous kinase Mus musculus 139-159 21887257-4 2011 We hypothesized that CS and TNFalpha increase NIK levels causing phosphorylation of IKKalpha, which leads to histone acetylation. Cesium 21-23 conserved helix-loop-helix ubiquitous kinase Mus musculus 84-92 21887257-6 2011 CS increased the phosphorylation levels of IKKalpha/NIK in lung epithelial cells and mouse lungs. Cesium 0-2 conserved helix-loop-helix ubiquitous kinase Mus musculus 43-51 21082860-7 2010 Furthermore, theasinensin A suppressed the phosphorylation of MAPKs, IkappaB kinase alpha/beta (IKKalpha/beta), and TGF-beta activated kinase (TAK1). theasinensin A 13-27 conserved helix-loop-helix ubiquitous kinase Mus musculus 69-89 21082860-7 2010 Furthermore, theasinensin A suppressed the phosphorylation of MAPKs, IkappaB kinase alpha/beta (IKKalpha/beta), and TGF-beta activated kinase (TAK1). theasinensin A 13-27 conserved helix-loop-helix ubiquitous kinase Mus musculus 90-109 20132051-8 2010 Pam(3)Cys stimulation of E14 ESCs was associated with induced NF-kappaB translocation, enhanced phosphorylation of IKK-alpha/beta, and enhanced mRNA, but not protein, expression of tumor necrosis factor-alpha, interferon-gamma, and IL-6. (3)cys 3-9 conserved helix-loop-helix ubiquitous kinase Mus musculus 115-124 20472709-7 2010 Interestingly, phosphorylated and total levels of IKKalpha, but not total and phosphorylated IKKbeta levels, were increased in lungs of Glrx1 KO mice compared with WT mice exposed to CS. Cesium 183-185 conserved helix-loop-helix ubiquitous kinase Mus musculus 50-58 20386985-6 2010 Most importantly, quercetin significantly prevented in vivo growth of ACC xenografts in nude mice, accompanied by induction of tumor cell apoptosis, suppression of NF-kappaB nuclear translocation, as well as down-regulation of Akt and IKK-alpha activation. Quercetin 18-27 conserved helix-loop-helix ubiquitous kinase Mus musculus 235-244 19278579-2 2009 METHODS: IKKalpha and IKKgamma targeting small interference RNA (siRNA) were designed to synthesize complementary oligonucleotide chains, then it was transfected into mouse macrophage cell line RAW264.7. Oligonucleotides 114-129 conserved helix-loop-helix ubiquitous kinase Mus musculus 9-17 19800637-6 2010 In adipose tissue, atorvastatin decreased macrophage infiltration and normalized IKK-alpha/beta phosphorylation; TNF-alpha, IL-6, and GLUT4 mRNA; and GLUT4 protein to control levels. Atorvastatin 19-31 conserved helix-loop-helix ubiquitous kinase Mus musculus 81-90 21779445-6 2010 The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases. Bismuth 65-67 conserved helix-loop-helix ubiquitous kinase Mus musculus 104-107 21779445-6 2010 The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases. Bismuth 87-89 conserved helix-loop-helix ubiquitous kinase Mus musculus 104-107 21779445-6 2010 The latter model was also used to evaluate in vivo activities of BI 5700.We found that BI 5700 inhibits IKK2 with an IC(50) of 9 nM and was highly selective as compared to other IKK family members (IKK1, IKKepsilon, and TBK1) and other kinases. Bismuth 87-89 conserved helix-loop-helix ubiquitous kinase Mus musculus 198-202 19363130-5 2009 The protein expression of IKK-alpha and IKK-beta were higher in Lepr(db) than in mLepr(db) mice; the expression of IKK-beta, but not the expression of IKK-alpha, was attenuated by MG-132, the antioxidant apocynin, or the genetic deletion of TNF-alpha in diabetic mice. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 180-186 conserved helix-loop-helix ubiquitous kinase Mus musculus 26-35 19666475-1 2009 Proinflammatory NF-kappaB activation requires the IkappaB (inhibitor of NF-kappaB) kinase (IKK) complex that contains two catalytic subunits named IKKalpha and IKKbeta and a regulatory subunit named NF-kappaB essential modulator (NEMO). ikappab 50-57 conserved helix-loop-helix ubiquitous kinase Mus musculus 147-155 19627202-5 2009 Moreover, the antioxidative AMS suppressed the activation of NF-kappaB and its dependent genes such as vascular cell adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 through inhibition of IkappaBalpha phosphorylation and activation of IkappaB kinase alpha/beta and mitogen-activated protein kinases (MAPKs). allyl methyl sulfide 28-31 conserved helix-loop-helix ubiquitous kinase Mus musculus 261-281 19169268-7 2009 Further study revealed that FLZ inhibited the phosphorylation of transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1), which is an upstream signaling molecule required for IKKalpha/beta, JNK and p38 activation. flz 28-31 conserved helix-loop-helix ubiquitous kinase Mus musculus 188-201 18508047-0 2008 Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner. arsenite 48-56 conserved helix-loop-helix ubiquitous kinase Mus musculus 5-13 19201823-3 2009 Thalidomide prevented the activation of nuclear factor (NF)-KB by down-regulating phosphorylation of inhibitory KB factor (IKB), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS-induced phosphorylation of AKT, p38 and stress-activated protein kinase (SAPK)/JNK. Thalidomide 0-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-155 19201823-3 2009 Thalidomide prevented the activation of nuclear factor (NF)-KB by down-regulating phosphorylation of inhibitory KB factor (IKB), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS-induced phosphorylation of AKT, p38 and stress-activated protein kinase (SAPK)/JNK. Thalidomide 179-190 conserved helix-loop-helix ubiquitous kinase Mus musculus 133-155 18688039-8 2009 Transient transfection of dominant negative IkappaB-kinase-alpha and double mutants of NF-kappaB-inducing kinase partially attenuated the CS extract-mediated loss of RelB in B cells and normalized the increased RelB level in macrophages. Cesium 138-140 conserved helix-loop-helix ubiquitous kinase Mus musculus 44-64 18688039-9 2009 Taken together, these data suggest that RelB is differentially regulated in response to CS exposure in macrophages, B cells, and in lung cells by IkappaB-kinase-alpha-dependent mechanism. Cesium 88-90 conserved helix-loop-helix ubiquitous kinase Mus musculus 146-166 18992279-10 2008 Furthermore, TET inhibited NF-kappaB activity, the critical transcriptional factor of the above mentioned inflammatory cytokines, by preventing the activation of IkappaBalpha kinasealpha (IKKalpha) and then inhibiting phosphorylation of IkappaBalpha to stabilize IkappaBalpha in intrahepatic leukocytes. tetrandrine 13-16 conserved helix-loop-helix ubiquitous kinase Mus musculus 162-197 18508047-4 2008 Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation. arsenite 39-47 conserved helix-loop-helix ubiquitous kinase Mus musculus 170-178 18508047-7 2008 Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner. arsenite 67-75 conserved helix-loop-helix ubiquitous kinase Mus musculus 34-42 17977820-0 2008 Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. Serine 19-25 conserved helix-loop-helix ubiquitous kinase Mus musculus 52-55 18222973-11 2008 DA-6034 strongly enhanced apoptosis and inhibited the expression of COX-2 and phospho-IKKalpha in inflammation-related colon cancer models. recoflavone 0-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 86-94 18239189-3 2008 We hypothesized that CS activates IKK alpha and causes histone acetylation on the promoters of pro-inflammatory genes, leading to sustained transcription of pro-inflammatory mediators in mouse lung in vivo and in human monocyte/macrophage cell line (MonoMac6) in vitro. Cesium 21-23 conserved helix-loop-helix ubiquitous kinase Mus musculus 34-43 18239189-4 2008 CS exposure to C57BL/6J mice resulted in activation of IKK alpha, leading to phosphorylation of ser10 and acetylation of lys9 on histone H3 on the promoters of IL-6 and MIP-2 genes in mouse lung. Cesium 0-2 conserved helix-loop-helix ubiquitous kinase Mus musculus 55-64 18239189-7 2008 Overexpression of IKK alpha was associated with augmentation of CS-induced pro-inflammatory effects, and phosphorylation of ser10 and acetylation of lys9 on histone H3, whereas transfection of IKK alpha dominant-negative mutants reduced CS-induced chromatin modification and pro-inflammatory cytokine release. Cesium 64-66 conserved helix-loop-helix ubiquitous kinase Mus musculus 18-27 18239189-7 2008 Overexpression of IKK alpha was associated with augmentation of CS-induced pro-inflammatory effects, and phosphorylation of ser10 and acetylation of lys9 on histone H3, whereas transfection of IKK alpha dominant-negative mutants reduced CS-induced chromatin modification and pro-inflammatory cytokine release. Cesium 237-239 conserved helix-loop-helix ubiquitous kinase Mus musculus 18-27 18239189-9 2008 Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3. Cesium 70-72 conserved helix-loop-helix ubiquitous kinase Mus musculus 40-49 17977820-6 2008 However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the IKK-binding domain plays an essential role for the formation and the function of the IKK complex. Serine 71-77 conserved helix-loop-helix ubiquitous kinase Mus musculus 102-105 17977820-8 2008 In contrast, the NEMO-IKKalpha interaction was only mildly affected by the phosphorylation of Ser(68). Serine 94-97 conserved helix-loop-helix ubiquitous kinase Mus musculus 22-30 17977820-9 2008 However, functional analysis revealed that Ser(68) phosphorylation primarily affects the activity of IKKalpha. Serine 43-46 conserved helix-loop-helix ubiquitous kinase Mus musculus 101-109 17890319-5 2007 The Ikkalpha(AA) mutation retarded tumor development in response to either 7,12-dimethylbenzaanthracene or the MMTV-c-neu (ErbB2/Her2) transgene but had no effect on MMTV-v-Ha-ras-induced cancer, although both oncogenes rely on cyclin D1. 7,12-dimethylbenzaanthracene 75-103 conserved helix-loop-helix ubiquitous kinase Mus musculus 4-12 18000063-3 2007 The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 213-257 conserved helix-loop-helix ubiquitous kinase Mus musculus 125-145 18000063-3 2007 The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 213-257 conserved helix-loop-helix ubiquitous kinase Mus musculus 147-155 18000063-3 2007 The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 259-263 conserved helix-loop-helix ubiquitous kinase Mus musculus 125-145 18000063-3 2007 The present study evaluates the ability of peptide corresponding to the NF-kappaB essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-kappaB in human parkinsonism. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 259-263 conserved helix-loop-helix ubiquitous kinase Mus musculus 147-155 17360634-6 2007 Subsequently, induction of IkappaB kinase-alpha by DeltaNp63alpha initiates epidermal terminal differentiation resulting in the formation of the spinous layer. deltanp63alpha 51-65 conserved helix-loop-helix ubiquitous kinase Mus musculus 27-47 17909021-10 2007 The phorbol ester tumor promoter induced higher mitogenic and angiogenic activities in Ikkalpha+/- than in Ikkalpha+/+ skin. Phorbol Esters 4-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 87-95 17909021-10 2007 The phorbol ester tumor promoter induced higher mitogenic and angiogenic activities in Ikkalpha+/- than in Ikkalpha+/+ skin. Phorbol Esters 4-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 107-115 17537731-5 2007 The mutation of IKKalpha putative nuclear localization sequence, which prevents its nuclear translocation, or of crucial serines in the IKKalpha activation loop completely inhibits p65 binding on icam-1 and mcp-1 promoters and rather enhances p65 binding on the ikappabalpha promoter. Serine 121-128 conserved helix-loop-helix ubiquitous kinase Mus musculus 136-144 17452332-7 2007 Furthermore, CDDP-mediated accumulation of endogenous p73alpha was not detected in mouse embryonic fibroblasts (MEFs) prepared from IKK-alpha-deficient mice, and CDDP sensitivity was significantly decreased in IKK-alpha-deficient MEFs compared with wild-type MEFs. Cisplatin 13-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 210-219 17452332-7 2007 Furthermore, CDDP-mediated accumulation of endogenous p73alpha was not detected in mouse embryonic fibroblasts (MEFs) prepared from IKK-alpha-deficient mice, and CDDP sensitivity was significantly decreased in IKK-alpha-deficient MEFs compared with wild-type MEFs. Cisplatin 162-166 conserved helix-loop-helix ubiquitous kinase Mus musculus 210-219 17404218-5 2007 Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo. Serine 76-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 51-59 17404218-5 2007 Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo. Serine 76-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 90-102 17404218-5 2007 Here we use mice bearing targeted mutations of the IKKalpha activation loop Ser(176/180) (IKKalpha(AA)) to address the B cell-intrinsic functions of NIK-IKKalpha signaling in vivo. Serine 76-79 conserved helix-loop-helix ubiquitous kinase Mus musculus 90-98 17351639-5 2007 Furthermore, we show that IKK1-deficient cells display impaired retinoic acid-induced gene transcription, and that IKK1 is recruited to the promoters of retinoic acid-regulated genes, suggesting that one mechanism by which IKK1 controls epidermal-barrier formation is by regulating the expression of retinoic acid receptor target genes in keratinocytes. Tretinoin 64-77 conserved helix-loop-helix ubiquitous kinase Mus musculus 26-30 16956889-6 2006 Pharmacological inhibition or antisense ablation of AR that catalyzes the reduction of GS-HNE to GS-DHN prevented PLC, PKC, IKKalpha/beta, and NF-kappaB activation caused by HNE and GS-HNE, but not by GS-DHN, suggesting that reduced GS-lipid aldehydes catalyzed by AR propagate LPS-induced production of inflammatory markers. gs-dhn 97-103 conserved helix-loop-helix ubiquitous kinase Mus musculus 124-137 16950795-8 2007 9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKKalpha/beta in TPA-treated mouse skin. 11e- 3-7 conserved helix-loop-helix ubiquitous kinase Mus musculus 80-93 16950795-8 2007 9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKKalpha/beta in TPA-treated mouse skin. Tetradecanoylphorbol Acetate 97-100 conserved helix-loop-helix ubiquitous kinase Mus musculus 80-93 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Serine 173-179 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-138 15829915-11 2005 These results suggest that ROS are implicated in transient downregulation of IKKalpha, beta, and gamma in cerebral ischemia. Reactive Oxygen Species 27-30 conserved helix-loop-helix ubiquitous kinase Mus musculus 77-85 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Serine 187-193 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-138 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Lysine 251-257 conserved helix-loop-helix ubiquitous kinase Mus musculus 134-138 15784689-6 2005 Inhibition of IKK by sulindac decreased IKKalpha phosphorylation, IkappaBalpha phosphorylation and degradation, NF-kappaB activation, and TNF production by BMMC. Sulindac 21-29 conserved helix-loop-helix ubiquitous kinase Mus musculus 40-48 15784689-10 2005 In addition, IgE + TNP-induced IKKalpha and IkappaBalpha phosphorylation was inhibited by a protein kinase C (PKC) inhibitor Ro 31-8220. Ro 31-8220 125-135 conserved helix-loop-helix ubiquitous kinase Mus musculus 31-39 15455341-8 2005 We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 72-75 conserved helix-loop-helix ubiquitous kinase Mus musculus 166-174 15695520-6 2005 To prove that the kinase activity of IKKalpha was required on a genomic scale, the same physiological rescue was performed with a kinase-dead, ATP binding domain IKKalpha mutant (IKKalpha(K44M)). Adenosine Triphosphate 143-146 conserved helix-loop-helix ubiquitous kinase Mus musculus 37-45 15020199-8 2004 Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 109-112 conserved helix-loop-helix ubiquitous kinase Mus musculus 146-154 16237959-0 2005 Neuroprotective effect of Chuk-Me-Sun-Dan on NMDA- and AMPA-evoked nitric oxide synthase activity in mouse brain. N-Methylaspartate 45-49 conserved helix-loop-helix ubiquitous kinase Mus musculus 26-30 15122342-9 2004 We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha. Tetradecanoylphorbol Acetate 75-78 conserved helix-loop-helix ubiquitous kinase Mus musculus 186-194 10820281-10 2000 Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity. Sulfhydryl Compounds 92-97 conserved helix-loop-helix ubiquitous kinase Mus musculus 39-48 15020199-8 2004 Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha. oleandrin 47-56 conserved helix-loop-helix ubiquitous kinase Mus musculus 146-154 15502405-5 2004 Piceatannol inhibited IkappaB kinase (IKK)-alpha and beta phosphorylation, and subsequently IkappaB-alpha phosphorylation in LPS-stimulated RAW 264.7 cells. 3,3',4,5'-tetrahydroxystilbene 0-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 22-48 15502405-7 2004 Piceatannol inhibited the phosphorylation of Akt and Raf-1 molecules, which regulated the activation of IKK-alpha and beta phosphorylation. 3,3',4,5'-tetrahydroxystilbene 0-11 conserved helix-loop-helix ubiquitous kinase Mus musculus 104-113 12403772-3 2003 BMS-345541 (4(2"-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline) was identified as a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC(50) = 0.3 microm, IKK-1 IC(50) = 4 microm). 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline 12-71 conserved helix-loop-helix ubiquitous kinase Mus musculus 174-179 11077049-8 2000 Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active. Curcumin 28-36 conserved helix-loop-helix ubiquitous kinase Mus musculus 55-71 11077049-8 2000 Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active. Curcumin 28-36 conserved helix-loop-helix ubiquitous kinase Mus musculus 73-77 11077049-8 2000 Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active. Octahydrocurcumin 181-198 conserved helix-loop-helix ubiquitous kinase Mus musculus 55-71 11077049-8 2000 Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active. Octahydrocurcumin 181-198 conserved helix-loop-helix ubiquitous kinase Mus musculus 73-77 11077049-9 2000 These results suggest that curcumin may exert its anti-inflammatory and anti-carcinogenic properties by suppressing the activation of NFkappaB through inhibition of IKK activity. Curcumin 27-35 conserved helix-loop-helix ubiquitous kinase Mus musculus 165-168 14681684-12 2003 Our data demonstrated that GTP inhibited UVB-induced: (i) activation of NF-kappaB, (ii) activation of IKKalpha, and (iii) phosphorylation and degradation of IkappaBalpha. Guanosine Triphosphate 27-30 conserved helix-loop-helix ubiquitous kinase Mus musculus 102-110 14585967-7 2003 Free NF-kappaB generated by DoxR-induced IkappaB degradation in IKK1/2(-/-) cells is able to activate chromatin based NF-kappaB reporter gene and expression of the endogenous target gene, IkappaBalpha. Doxorubicin 28-32 conserved helix-loop-helix ubiquitous kinase Mus musculus 64-68 12704203-3 2003 For example, mice that carry a mutation in one of the subunits of the IkappaB kinase, IKKalpha, cannot lactate despite the presence of histologically normal alveolar compartment and the expression of milk protein genes. Lactic Acid 103-110 conserved helix-loop-helix ubiquitous kinase Mus musculus 86-94 12070292-2 2002 Activation of NF-kappaB is critically dependent on serine phosphorylation of the IkappaB protein by the multi-component IkappaB kinase (IKK) containing two catalytic subunits (IKKalpha and IKKbeta) and one regulatory subunit (IKKgamma). Serine 51-57 conserved helix-loop-helix ubiquitous kinase Mus musculus 176-184 11287960-1 2001 The IKKalpha and IKKbeta catalytic subunits of IkappaB kinase (IKK) share 51% amino-acid identity and similar biochemical activities: they both phosphorylate IkappaB proteins at serines that trigger their degradation. Serine 178-185 conserved helix-loop-helix ubiquitous kinase Mus musculus 4-12 10820281-10 2000 Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity. Cysteine 145-153 conserved helix-loop-helix ubiquitous kinase Mus musculus 39-48 10593965-0 1999 Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. Aminosalicylic Acid 0-19 conserved helix-loop-helix ubiquitous kinase Mus musculus 29-49 10593965-6 1999 Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA. Glutathione 21-32 conserved helix-loop-helix ubiquitous kinase Mus musculus 118-126 10593965-6 1999 Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA. Mesalamine 185-190 conserved helix-loop-helix ubiquitous kinase Mus musculus 118-126 10593965-7 1999 Recombinant IKKalpha and IKKbeta autophosphorylation and their phosphorylation of glutathione S-transferase-IkappaBalpha are inhibited by 5-ASA. Mesalamine 138-143 conserved helix-loop-helix ubiquitous kinase Mus musculus 12-20 10593965-8 1999 However, IKKalpha serine phosphorylation by its upstream kinase in either intact cells or cellular extracts is not blocked by 5-ASA. Serine 18-24 conserved helix-loop-helix ubiquitous kinase Mus musculus 9-17 10593965-10 1999 In summary, 5-ASA inhibits TNFalpha-stimulated IKKalpha kinase activity toward IkappaBalpha in intestinal epithelial cells. Mesalamine 12-17 conserved helix-loop-helix ubiquitous kinase Mus musculus 47-55 10229185-1 1999 IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB. Serine 143-149 conserved helix-loop-helix ubiquitous kinase Mus musculus 0-30 10229185-1 1999 IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB. Serine 143-149 conserved helix-loop-helix ubiquitous kinase Mus musculus 32-41 10229185-1 1999 IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB. Serine 143-149 conserved helix-loop-helix ubiquitous kinase Mus musculus 32-35