PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33815098-0	2021	Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1.	squamosamide	0-12	dynamin 1-like	Mus musculus	84-109
9570752-7	1998	Immunolocalization studies in Chinese hamster ovary (CHO) cells using an epitope-tagged form of DRP1 and confocal microscopy show that this protein is concentrated in a perinuclear region that labels with the endoplasmic reticulum marker DiOC6(3) and the Golgi marker C5-DMB-Cer.	3,3'-dihexyl-2,2'-oxacarbocyanine	238-246	dynamin 1-like	Mus musculus	96-100
9570752-9	1998	Furthermore, overexpression of a cDNA encoding a GTP binding site mutant of DRP1 (DRP1(K38E)) in CHO cells decreases the amount of a secreted luciferase reporter protein, whereas the overexpression of wild-type DRP1 increases the secretion of this marker.	Guanosine Triphosphate	49-52	dynamin 1-like	Mus musculus	76-80
9570752-9	1998	Furthermore, overexpression of a cDNA encoding a GTP binding site mutant of DRP1 (DRP1(K38E)) in CHO cells decreases the amount of a secreted luciferase reporter protein, whereas the overexpression of wild-type DRP1 increases the secretion of this marker.	Guanosine Triphosphate	49-52	dynamin 1-like	Mus musculus	82-86
9570752-9	1998	Furthermore, overexpression of a cDNA encoding a GTP binding site mutant of DRP1 (DRP1(K38E)) in CHO cells decreases the amount of a secreted luciferase reporter protein, whereas the overexpression of wild-type DRP1 increases the secretion of this marker.	Guanosine Triphosphate	49-52	dynamin 1-like	Mus musculus	82-86
7978411-5	1994	Halothane median effective concentration (EC50) was determined by using the end-point of loss of righting reflex in two replicate lines of mice selected for diazepam sensitivity (resistant mice = diazepam high performance-1 and -2 [DHP-1 and DHP-2], sensitive mice = diazepam low performance-1 and -2 [DLP-1 and DLP-2]).	Halothane	0-9	dynamin 1-like	Mus musculus	302-307
7978411-6	1994	DLP-1 and DLP-2 mice were sensitive to halothane, whereas DHP-1 and DHP-2 mice were resistant to halothane.	Halothane	39-48	dynamin 1-like	Mus musculus	0-5
7978411-7	1994	Halothane EC50 in the DLP-1 and DHP-1 mice was 0.86 +/- 0.01 (SE) and 1.10 +/- 0.04 atm%, respectively (P < 0.0001), and that in the DLP-2 and DHP-2 mice was 0.88 +/- 0.01 and 0.97 +/- 0.02 atm%, respectively (P < 0.0001).	Halothane	0-9	dynamin 1-like	Mus musculus	22-27
33815098-0	2021	Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1.	flz	24-27	dynamin 1-like	Mus musculus	84-109
33815098-5	2021	In this study, we investigated the effect of FLZ and the role of Drp1 on 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial fission in neurons.	1-Methyl-4-phenylpyridinium	73-100	dynamin 1-like	Mus musculus	65-69
33815098-6	2021	We observed that FLZ blocked Drp1, inhibited Drp1 enzyme activity, and reduced excessive mitochondrial fission in cultured neurons.	flz	17-20	dynamin 1-like	Mus musculus	29-33
33815098-6	2021	We observed that FLZ blocked Drp1, inhibited Drp1 enzyme activity, and reduced excessive mitochondrial fission in cultured neurons.	flz	17-20	dynamin 1-like	Mus musculus	45-49
33815098-10	2021	The in vivo results revealed that FLZ significantly reduced the mitochondrial translocation of Drp1 in the midbrain of PD mice, which, in turn, reduced the mitochondrial fragmentation in mouse substantia nigra neurons.	flz	34-37	dynamin 1-like	Mus musculus	95-99
34954498-9	2022	Mitochondrial ultrastructure analysis showed that the increased density of mitochondria induced by SNI was recovered by Drp1 OE which, however, did not change mitochondrial morphology and vacuole parameters within SDH.	sni	99-102	dynamin 1-like	Mus musculus	120-124
34793771-0	2022	Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.	Emodin	0-6	dynamin 1-like	Mus musculus	76-80
34793771-10	2022	The phosphorylation of dynamin-related protein 1 (DRP1) at Ser616, a master regulator of mitochondrial fission, was upregulated in both models of I/R and H/R injury, and this upregulation was blocked by emodin.	Emodin	203-209	dynamin 1-like	Mus musculus	23-48
34793771-10	2022	The phosphorylation of dynamin-related protein 1 (DRP1) at Ser616, a master regulator of mitochondrial fission, was upregulated in both models of I/R and H/R injury, and this upregulation was blocked by emodin.	Emodin	203-209	dynamin 1-like	Mus musculus	50-54
34793771-11	2022	Using computational cognate protein kinase prediction and specific kinase inhibitors, we found that emodin inhibited the phosphorylation of calcium/calmodulin-dependent protein kinase II (https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1554), thereby inhibiting its kinase activity and reducing the phosphorylation of DRP1 at Ser616.	Emodin	100-106	dynamin 1-like	Mus musculus	341-345
34793771-11	2022	Using computational cognate protein kinase prediction and specific kinase inhibitors, we found that emodin inhibited the phosphorylation of calcium/calmodulin-dependent protein kinase II (https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1554), thereby inhibiting its kinase activity and reducing the phosphorylation of DRP1 at Ser616.	Calcium	140-147	dynamin 1-like	Mus musculus	341-345
34777009-10	2021	At the same time, empagliflozin enhanced fusion protein mitofusin 2 (MFN2) expression, while decreasing the levels of the fission marker phosphorylated dynamin-related protein 1 (Ser616) (p-DRP1 (Ser616)) in epididymal and perirenal WAT.	empagliflozin	18-31	dynamin 1-like	Mus musculus	152-177
34618332-6	2022	We found that Drp1 phosphorylation at serine 616 in macrophages/microglia was decreased with Mdivi-1 treatment, which was accompanied by decreased antigen presentation capacity of the macrophages/microglia in the EAE mouse spinal cord.	Serine	38-44	dynamin 1-like	Mus musculus	14-18
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	dynamin 1-like	Mus musculus	34-59
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	dynamin 1-like	Mus musculus	61-65
34310799-6	2021	In contrast, the transfection of ALR into LEPCs significantly inhibited Drp1 phosphorylation, thereby favoring the maintenance of mitochondrial integrity and the preservation of ATP contents in LEPCs.	Adenosine Triphosphate	178-181	dynamin 1-like	Mus musculus	72-76
34705256-13	2021	In addition, ogt knockdown markedly decreased serine 637 phosphorylation level of mitochondrial fission protein dynamin-related protein 1 (Drp1) and promoted Drp1 translocation from the cytosol to the mitochondria.	Serine	46-52	dynamin 1-like	Mus musculus	112-137
34705256-13	2021	In addition, ogt knockdown markedly decreased serine 637 phosphorylation level of mitochondrial fission protein dynamin-related protein 1 (Drp1) and promoted Drp1 translocation from the cytosol to the mitochondria.	Serine	46-52	dynamin 1-like	Mus musculus	139-143
34777009-10	2021	At the same time, empagliflozin enhanced fusion protein mitofusin 2 (MFN2) expression, while decreasing the levels of the fission marker phosphorylated dynamin-related protein 1 (Ser616) (p-DRP1 (Ser616)) in epididymal and perirenal WAT.	empagliflozin	18-31	dynamin 1-like	Mus musculus	190-194
34146589-7	2021	We found that inhibition of Drp1 could ameliorate the motor deficits and the expression of tyrosine hydroxylase in the mice of the PD model.	Tyrosine	91-99	dynamin 1-like	Mus musculus	28-32
34631868-0	2021	Melatonin Promotes in vitro Development of Vitrified-Warmed Mouse GV Oocytes, Potentially by Modulating Phosphorylation of Drp1.	Melatonin	0-9	dynamin 1-like	Mus musculus	123-127
34631868-2	2021	The objective of the present study was to investigate whether melatonin can improve the mitochondrial function during in vitro maturation of vitrified-warmed mouse germinal vesicle (GV) oocytes by modulating phosphorylation of dynamin related protein 1 (Drp1).	Melatonin	62-71	dynamin 1-like	Mus musculus	227-252
34631868-2	2021	The objective of the present study was to investigate whether melatonin can improve the mitochondrial function during in vitro maturation of vitrified-warmed mouse germinal vesicle (GV) oocytes by modulating phosphorylation of dynamin related protein 1 (Drp1).	Melatonin	62-71	dynamin 1-like	Mus musculus	254-258
34631868-7	2021	Therefore, we concluded that 10-7mol/L melatonin improved mitochondrial function, reduced oxidative stress and inhibited apoptosis by regulating phosphorylation of Drp1, thereby enhancing in vitro development of vitrified-warmed mouse GV oocytes.	Melatonin	39-48	dynamin 1-like	Mus musculus	164-168
34603602-10	2021	NaHS inhibited cell proliferation and hydroxyproline secretion, decreased collagen I, collagen III, alpha-SMA, and DRP1 expression, alleviated oxidative stress, and improved mitochondrial respiration function and membrane potential in Ang II-stimulated cardiac fibroblasts, which were unavailable after SIRT3 was silenced.	sodium bisulfide	0-4	dynamin 1-like	Mus musculus	115-119
34603602-11	2021	In vivo, NaHS reduced hydroxyproline content, ameliorated perivascular and interstitial collagen deposition, and inhibited collagen I, collagen III, and DRP1 expression in the myocardium of WT mice but not SIRT3 KO mice with TAC.	sodium bisulfide	9-13	dynamin 1-like	Mus musculus	153-157
35306208-7	2022	Apelin-13-induced MCU-dependent mitochondrial calcium uptake further increased mitochondrial ROS (mtROS) concentrations and promoted mitophagy, which can be evidenced through the upregulation of the Dynamin-related protein 1(Drp1), PTEN-induced kinase 1 (PINK1), and Parkin.	Calcium	46-53	dynamin 1-like	Mus musculus	199-224
34433037-5	2021	Mice carrying a homozygous Drp1 S600A knockin (Drp1 KI) mutation display larger mitochondria and enhanced lipid oxidation and respiratory capacities, granting improved glucose tolerance and thermogenic response upon high-fat feeding.	Glucose	168-175	dynamin 1-like	Mus musculus	27-31
34433037-5	2021	Mice carrying a homozygous Drp1 S600A knockin (Drp1 KI) mutation display larger mitochondria and enhanced lipid oxidation and respiratory capacities, granting improved glucose tolerance and thermogenic response upon high-fat feeding.	Glucose	168-175	dynamin 1-like	Mus musculus	47-51
34462641-14	2021	The RIP1, RIP3, Drp1, IL-1beta, IL-18, and caspase-1 mRNA levels in the QYSX, 5-ASA, SX, and QY groups were significantly lower than those in the DSS group (P < 0.05), but there were no differences between the QYSX group and the 5-ASA group.	Mesalamine	78-83	dynamin 1-like	Mus musculus	16-20
34462641-16	2021	The levels of Drp1, caspase-1, FIS1, and LC3a/b in the QYSX group and the 5-ASA group were lower than those in the DSS group (P < 0.05).	Mesalamine	74-79	dynamin 1-like	Mus musculus	14-18
34299059-8	2021	Dox (10 mg/kg) increased the cardiac tissue levels of 4-hydroxynonenal, NQO1, C-MYC, and DRP1 phosphorylation at serine 616, but these increases were not observed with vitamin D + Dox (10 mg/kg).	Doxorubicin	0-3	dynamin 1-like	Mus musculus	89-93
34299059-8	2021	Dox (10 mg/kg) increased the cardiac tissue levels of 4-hydroxynonenal, NQO1, C-MYC, and DRP1 phosphorylation at serine 616, but these increases were not observed with vitamin D + Dox (10 mg/kg).	Serine	113-119	dynamin 1-like	Mus musculus	89-93
35306208-7	2022	Apelin-13-induced MCU-dependent mitochondrial calcium uptake further increased mitochondrial ROS (mtROS) concentrations and promoted mitophagy, which can be evidenced through the upregulation of the Dynamin-related protein 1(Drp1), PTEN-induced kinase 1 (PINK1), and Parkin.	Calcium	46-53	dynamin 1-like	Mus musculus	225-229
35139535-8	2022	SIN-1, the peroxynitrite generator, significantly up-regulated alkaline phosphatase (ALP) and Runx2 expression in VICs via tyrosine nitration of dynamin-related protein 1 (DRP1) at Y628.	Peroxynitrous Acid	11-24	dynamin 1-like	Mus musculus	145-170
35611585-11	2022	Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB alpha on MPTP-treated mice.	SR 8278	13-19	dynamin 1-like	Mus musculus	81-85
35611585-11	2022	Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB alpha on MPTP-treated mice.	sinapinic acid	25-37	dynamin 1-like	Mus musculus	81-85
35611585-11	2022	Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB alpha on MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	114-118	dynamin 1-like	Mus musculus	81-85
35202791-7	2022	In contrast, streptozotocin-induced diabetes significantly exacerbated neuraminidase-induced podocyte damage and albuminuria, and was accompanied by increased Drp1 expression and enhanced mitochondrial fission in podocytes.	Streptozocin	13-27	dynamin 1-like	Mus musculus	159-163
35139535-8	2022	SIN-1, the peroxynitrite generator, significantly up-regulated alkaline phosphatase (ALP) and Runx2 expression in VICs via tyrosine nitration of dynamin-related protein 1 (DRP1) at Y628.	Peroxynitrous Acid	11-24	dynamin 1-like	Mus musculus	172-176
35139535-8	2022	SIN-1, the peroxynitrite generator, significantly up-regulated alkaline phosphatase (ALP) and Runx2 expression in VICs via tyrosine nitration of dynamin-related protein 1 (DRP1) at Y628.	Tyrosine	123-131	dynamin 1-like	Mus musculus	145-170
35139535-8	2022	SIN-1, the peroxynitrite generator, significantly up-regulated alkaline phosphatase (ALP) and Runx2 expression in VICs via tyrosine nitration of dynamin-related protein 1 (DRP1) at Y628.	Tyrosine	123-131	dynamin 1-like	Mus musculus	172-176
35139535-10	2022	CONCLUSION: The reduction in endothelial-dependent BH4 levels promoted peroxynitrite formation, which subsequently resulted in DRP1 tyrosine nitration and osteoblastic differentiation of VICs, thereby leading to aortic valve calcification.	sapropterin	51-54	dynamin 1-like	Mus musculus	127-131
35139535-10	2022	CONCLUSION: The reduction in endothelial-dependent BH4 levels promoted peroxynitrite formation, which subsequently resulted in DRP1 tyrosine nitration and osteoblastic differentiation of VICs, thereby leading to aortic valve calcification.	Peroxynitrous Acid	71-84	dynamin 1-like	Mus musculus	127-131
35139535-10	2022	CONCLUSION: The reduction in endothelial-dependent BH4 levels promoted peroxynitrite formation, which subsequently resulted in DRP1 tyrosine nitration and osteoblastic differentiation of VICs, thereby leading to aortic valve calcification.	Tyrosine	132-140	dynamin 1-like	Mus musculus	127-131
35122996-0	2022	Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3beta/Drp1-dependent mitochondrial fission and apoptosis.	Sevoflurane	0-11	dynamin 1-like	Mus musculus	71-75
35395467-7	2022	In addition, metformin therapy increased mitochondrial membrane potential, with a reduction in mitochondrial reactive oxygen species, MDA and SOD levels, and restored mitochondrial balance through enhanced expression of dynamin-related protein 1 (Drp1).	Metformin	13-22	dynamin 1-like	Mus musculus	220-245
35395467-7	2022	In addition, metformin therapy increased mitochondrial membrane potential, with a reduction in mitochondrial reactive oxygen species, MDA and SOD levels, and restored mitochondrial balance through enhanced expression of dynamin-related protein 1 (Drp1).	Metformin	13-22	dynamin 1-like	Mus musculus	247-251
35392573-0	2022	Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1.	Metformin	0-9	dynamin 1-like	Mus musculus	110-114
35392573-11	2022	In cultured neurons, high glucose induced a high phosphorylated level of dynamin-related protein 1 (DRP1) and increased oxidative stress, resulting in cell apoptosis.	Glucose	26-33	dynamin 1-like	Mus musculus	73-98
35392573-11	2022	In cultured neurons, high glucose induced a high phosphorylated level of dynamin-related protein 1 (DRP1) and increased oxidative stress, resulting in cell apoptosis.	Glucose	26-33	dynamin 1-like	Mus musculus	100-104
35122996-3	2022	This study explored whether sevoflurane induces neurotoxicity by activating a GSK3beta (glycogen synthase kinase 3beta)/Drp1 (dynamin-related protein-1)-dependent mitochondrial fission and apoptosis.	Sevoflurane	28-39	dynamin 1-like	Mus musculus	120-124
35122996-3	2022	This study explored whether sevoflurane induces neurotoxicity by activating a GSK3beta (glycogen synthase kinase 3beta)/Drp1 (dynamin-related protein-1)-dependent mitochondrial fission and apoptosis.	Sevoflurane	28-39	dynamin 1-like	Mus musculus	126-151
35122996-5	2022	Additionally, sevoflurane upregulated GSK3beta stability and activation, promoted phosphorylation of Drp1 at Ser616 along with its translocation to mitochondria and resulted in increasing cytochrome c and cleaved casepase-3 in hippocampus of neonatal mice and in human SK-N-SH cells.	Sevoflurane	14-25	dynamin 1-like	Mus musculus	101-105
35103832-8	2022	Further, we found that baicalin decreased the PDE4 levels and upregulated the levels of phosphorylated Ser157 site of vasodilator-stimulated phosphoprotein (pVASPs157) and phosphorylated Ser637 site of mitochondrial dynamin-related protein 1 (pDrp1S637).	baicalin	23-31	dynamin 1-like	Mus musculus	216-241
34052344-10	2021	Moreover, both NAC and Drp1 ameliorated tissue damage and inflammation, and decreased expression of p-Drp1 and Drp1 in mice with periodontitis.	Acetylcysteine	15-18	dynamin 1-like	Mus musculus	102-106
35159089-11	2022	Furthermore, inhibition of Drp1 using pharmacologic inhibitors (Mdivi-1) or RNA interference (siDNM1L) decreased mito-COX-2/p-Drp1Ser616 interaction-mediated mitochondrial fission, and increased apoptosis in HCC cells treated with platinum drugs.	Platinum	231-239	dynamin 1-like	Mus musculus	27-31
35078269-4	2022	Drp1 is primarily located in the cytosol, from where it translocates to the mitochondrial outer membrane and drives the mitochondrial fission via GTP hydrolysis.	Guanosine Triphosphate	146-149	dynamin 1-like	Mus musculus	0-4
34052344-10	2021	Moreover, both NAC and Drp1 ameliorated tissue damage and inflammation, and decreased expression of p-Drp1 and Drp1 in mice with periodontitis.	Acetylcysteine	15-18	dynamin 1-like	Mus musculus	102-106
33850055-0	2021	DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.	Nitric Oxide	76-88	dynamin 1-like	Mus musculus	100-104
33895866-0	2021	Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation.	Glutamine	0-9	dynamin 1-like	Mus musculus	82-86
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Reactive Oxygen Species	14-37	dynamin 1-like	Mus musculus	131-156
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Reactive Oxygen Species	14-37	dynamin 1-like	Mus musculus	157-161
33968030-6	2021	Mechanistically, metformin treatment modulated the phosphorylation of dynamin-related protein 1 (Drp-1) and mitochondrial fission 1 protein (FIS1), resulting in increased mass in effector T cells.	Metformin	17-26	dynamin 1-like	Mus musculus	70-95
33968030-6	2021	Mechanistically, metformin treatment modulated the phosphorylation of dynamin-related protein 1 (Drp-1) and mitochondrial fission 1 protein (FIS1), resulting in increased mass in effector T cells.	Metformin	17-26	dynamin 1-like	Mus musculus	97-102
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Reactive Oxygen Species	39-42	dynamin 1-like	Mus musculus	131-156
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Reactive Oxygen Species	39-42	dynamin 1-like	Mus musculus	157-161
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Glutamine	47-56	dynamin 1-like	Mus musculus	131-156
33895866-6	2021	Production of reactive oxygen species (ROS) in glutamine limiting condition induces MAPK-ERK1/2 signaling pathway to phosphorylate dynamin-related protein-1(DRP1) at Ser616.	Glutamine	47-56	dynamin 1-like	Mus musculus	157-161
33895866-10	2021	Interestingly, the combinatorial treatment of L-DON with DRP1 inhibitor (MDiVi-1) reduces the stem cell population in tumor tissue in mouse model.	Diazooxonorleucine	46-51	dynamin 1-like	Mus musculus	57-61
33110216-9	2021	ALR-transfection significantly decreased Drp1 SUMOylation, attenuated the IRI-induced mitochondrial fission and preserved mitochondrial stability and function.	alr	0-3	dynamin 1-like	Mus musculus	41-45
33848899-10	2021	Taken together, these results suggest that the combination of glyphosate and hard water, even at environmental exposure levels, enhances pyroptosis and ongoing tubulointerstitial inflammation through excessive Drp1-mediated mitochondrial fission.	glyphosate	62-72	dynamin 1-like	Mus musculus	210-214
33848899-10	2021	Taken together, these results suggest that the combination of glyphosate and hard water, even at environmental exposure levels, enhances pyroptosis and ongoing tubulointerstitial inflammation through excessive Drp1-mediated mitochondrial fission.	Water	82-87	dynamin 1-like	Mus musculus	210-214
33110216-13	2021	This study showed that the regulation of Drp1 SUMOylation by ALR protects mitochondria from fission, rescuing hepatocytes from IRI-induced apoptosis.	alr	61-64	dynamin 1-like	Mus musculus	41-45
33539948-6	2021	Nrf2 gene knockdown in LPS-treated A549 cells prevented the protective effect of MitoQ from decreasing Drp1-mediated mitochondrial fission, AEC apoptosis and barrier breakdown.	mitoquinone	81-86	dynamin 1-like	Mus musculus	103-107
33689681-4	2021	In support of the role for mitochondrial fission and fatty acids oxidation, Drp1 cKO mice showed attenuated palmitic acid-induced mitochondrial respiration.	Palmitic Acid	108-121	dynamin 1-like	Mus musculus	76-80
33539948-0	2021	MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway.	mitoquinone	0-5	dynamin 1-like	Mus musculus	72-76
33539948-7	2021	The lung protective effect of MitoQ by regulating the Drp1-mediated mitochondrial fission, AEC apoptosis and barrier breakdown was further confirmed in vivo with LPS-induced ALI mouse model.	mitoquinone	30-35	dynamin 1-like	Mus musculus	54-58
33539948-4	2021	Moreover, the protective role of MitoQ was attenuated with Drp1 overexpression.	mitoquinone	33-38	dynamin 1-like	Mus musculus	59-63
33539948-9	2021	We therefore conclude that MitoQ exerts ALI-protective effects by preventing Nrf2/Drp1-mediated mitochondrial fission, AEC apoptosis as well as barrier breakdown.	mitoquinone	27-32	dynamin 1-like	Mus musculus	82-86
33300446-12	2021	DNM1L-Ser616 and MAPK/ERK phosphorylation which mediate mitochondrial fission and downstream mitophagic processes was apparent in WT using FCCP-induced stress but not mutant MEFs, despite similar total MAPK/ERK and DNM1L levels.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	139-143	dynamin 1-like	Mus musculus	0-5
32384150-6	2021	In C57BL6 mice treated with angiotensin II plus beta-aminopropionitrile, AAA tissue also showed an increase in Drp1 expression.	Aminopropionitrile	48-71	dynamin 1-like	Mus musculus	111-115
32384150-10	2021	As with mdivi1, Drp1+/- mice treated with angiotensin II plus beta-aminopropionitrile showed a decrease in AAA compared to control Drp1+/+ mice.	Aminopropionitrile	62-85	dynamin 1-like	Mus musculus	16-20
32384150-10	2021	As with mdivi1, Drp1+/- mice treated with angiotensin II plus beta-aminopropionitrile showed a decrease in AAA compared to control Drp1+/+ mice.	Aminopropionitrile	62-85	dynamin 1-like	Mus musculus	131-135
33300446-12	2021	DNM1L-Ser616 and MAPK/ERK phosphorylation which mediate mitochondrial fission and downstream mitophagic processes was apparent in WT using FCCP-induced stress but not mutant MEFs, despite similar total MAPK/ERK and DNM1L levels.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	139-143	dynamin 1-like	Mus musculus	215-220
33570219-4	2021	The results showed that ABA effectively stunted the development of airway inflammation, and concordantly downregulated OVA-induced activation of NLRP3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	Abscisic Acid	24-27	dynamin 1-like	Mus musculus	317-342
33570219-4	2021	The results showed that ABA effectively stunted the development of airway inflammation, and concordantly downregulated OVA-induced activation of NLRP3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	Abscisic Acid	24-27	dynamin 1-like	Mus musculus	344-348
33422108-6	2021	In this study, we identified that Drp1 is regulated by O-GlcNAcylation in AD models.	o-glcnacylation	55-70	dynamin 1-like	Mus musculus	34-38
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnac	31-39	dynamin 1-like	Mus musculus	50-54
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnac	31-39	dynamin 1-like	Mus musculus	90-94
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnacylation	95-110	dynamin 1-like	Mus musculus	50-54
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnacylation	95-110	dynamin 1-like	Mus musculus	90-94
33004813-3	2020	Knockout (KO) of PINCH-1 increases dynamin-related protein 1 (DRP1) expression and mitochondrial fragmentation, which suppresses kindlin-2 mitochondrial translocation and interaction with pyrroline-5-carboxylate reductase 1 (PYCR1), resulting in inhibition of proline synthesis and cell proliferation.	Proline	260-267	dynamin 1-like	Mus musculus	62-66
32618019-7	2020	The Seph-induced apoptosis in hepatocytes could be alleviated by Mdivi-1 (50 muM, a dynamin-related protein 1 inhibitor), as well as SP600125 (25 muM, a specific JNK inhibitor) and ZVAD-fmk (50 muM, a general caspase inhibitor).	seneciphylline	4-8	dynamin 1-like	Mus musculus	84-109
33004813-4	2020	Depletion of DRP1 reverses PINCH-1 deficiency-induced defects on mitochondrial dynamics, proline synthesis and cell proliferation.	Proline	89-96	dynamin 1-like	Mus musculus	13-17
33004813-7	2020	Our results identify a signaling axis consisting of PINCH-1, DRP1 and PYCR1 that regulates mitochondrial dynamics and proline synthesis, and suggest an attractive strategy for alleviation of tumor growth.	Proline	118-125	dynamin 1-like	Mus musculus	61-65
33080440-8	2020	Moreover, Stat2 boosts Drp1 phosphorylation at serine 616, required for Drp1-mediated mitochondrial fission.	Serine	47-53	dynamin 1-like	Mus musculus	23-27
32436179-0	2020	Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice.	Acrolein	0-8	dynamin 1-like	Mus musculus	82-86
32436179-4	2020	In primary neurons, acrolein induced an increase in mitochondrial fragmentation, loss of mitochondrial membrane potential, generation of reactive oxidative species, and release of mitochondrial cytochrome c. Mechanistically, acrolein facilitated the translocation of dynamin-related protein1 (Drp1) from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.	Acrolein	20-28	dynamin 1-like	Mus musculus	267-291
32436179-4	2020	In primary neurons, acrolein induced an increase in mitochondrial fragmentation, loss of mitochondrial membrane potential, generation of reactive oxidative species, and release of mitochondrial cytochrome c. Mechanistically, acrolein facilitated the translocation of dynamin-related protein1 (Drp1) from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.	Acrolein	20-28	dynamin 1-like	Mus musculus	293-297
32436179-4	2020	In primary neurons, acrolein induced an increase in mitochondrial fragmentation, loss of mitochondrial membrane potential, generation of reactive oxidative species, and release of mitochondrial cytochrome c. Mechanistically, acrolein facilitated the translocation of dynamin-related protein1 (Drp1) from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.	Acrolein	225-233	dynamin 1-like	Mus musculus	267-291
32436179-4	2020	In primary neurons, acrolein induced an increase in mitochondrial fragmentation, loss of mitochondrial membrane potential, generation of reactive oxidative species, and release of mitochondrial cytochrome c. Mechanistically, acrolein facilitated the translocation of dynamin-related protein1 (Drp1) from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.	Acrolein	225-233	dynamin 1-like	Mus musculus	293-297
32436179-5	2020	Further studies found that treatment with hydralazine (an acrolein scavenger) significantly reversed Drp1 translocation and the morphological damage of mitochondria after ICH.	Hydralazine	42-53	dynamin 1-like	Mus musculus	101-105
32436179-5	2020	Further studies found that treatment with hydralazine (an acrolein scavenger) significantly reversed Drp1 translocation and the morphological damage of mitochondria after ICH.	Acrolein	58-66	dynamin 1-like	Mus musculus	101-105
32436179-8	2020	Meanwhile, we uncovered a novel mechanism by which Drp1-mediated mitochondrial oxidative damage is involved in acrolein-induced brain injury.	Acrolein	111-119	dynamin 1-like	Mus musculus	51-55
33080440-8	2020	Moreover, Stat2 boosts Drp1 phosphorylation at serine 616, required for Drp1-mediated mitochondrial fission.	Serine	47-53	dynamin 1-like	Mus musculus	72-76
32686869-7	2020	LPS triggered acute Drp1 phosphorylation at serine 635 (S635), followed by sustained Drp1 dephosphorylation at serine 656 (S656), in BMMs.	Serine	44-50	dynamin 1-like	Mus musculus	20-24
32901052-5	2020	Consequently, GFP-tagged Drp1 constitutes aberrantly stable, GTP-resistant supramolecular assemblies both in vitro and in vivo, neither of which reflects a more dynamic native Drp1 oligomerization state.	Guanosine Triphosphate	61-64	dynamin 1-like	Mus musculus	25-29
32901052-6	2020	Indeed, GFP-tagged Drp1 is detected more frequently per unit length over mitochondria in Drp1-null mouse embryonic fibroblasts (MEFs) compared to wild-type (wt) MEFs, indicating that the drastically reduced GTP turnover restricts oligomer disassembly from the mitochondrial surface relative to mixed oligomers comprising native and GFP-tagged Drp1.	Guanosine Triphosphate	207-210	dynamin 1-like	Mus musculus	19-23
32521505-9	2020	In particular, the Dnm1l knockout most significantly affected mitochondrial morphology, energy metabolism, and ATP production in ESCs.	Adenosine Triphosphate	111-114	dynamin 1-like	Mus musculus	19-24
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	dynamin 1-like	Mus musculus	165-190
32479918-11	2020	Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1).	Vitamin D	15-24	dynamin 1-like	Mus musculus	192-196
32994406-9	2020	Finally, fragmented mitochondria and Drp1 mitochondrial translocation induced by high glucose were reduced following treatment with Mdivi1.	Glucose	86-93	dynamin 1-like	Mus musculus	37-41
32215908-11	2020	Moreover, muscone inhibited dynamin-related protein 1 activation in activated BV2 cells and injured neurons, whereby it rescued mitochondrial fragmentation and reactive oxygen species production, which regulate a wide range of inflammatory and apoptotic molecules.	muscone	10-17	dynamin 1-like	Mus musculus	28-53
32686869-7	2020	LPS triggered acute Drp1 phosphorylation at serine 635 (S635), followed by sustained Drp1 dephosphorylation at serine 656 (S656), in BMMs.	Serine	111-117	dynamin 1-like	Mus musculus	85-89
32339784-0	2020	Mitophagy Inhibitor Liensinine Suppresses Doxorubicin-Induced Cardiotoxicity through Inhibition of Drp1-Mediated Maladaptive Mitochondrial Fission.	liensinine	20-30	dynamin 1-like	Mus musculus	99-103
32493171-10	2020	Pharmacological inhibition or knockdown of Drp1 decreased the mitochondrial reactive oxygen species and chemotactic activity in cultured macrophages.	Reactive Oxygen Species	76-99	dynamin 1-like	Mus musculus	43-47
32339784-0	2020	Mitophagy Inhibitor Liensinine Suppresses Doxorubicin-Induced Cardiotoxicity through Inhibition of Drp1-Mediated Maladaptive Mitochondrial Fission.	Doxorubicin	42-53	dynamin 1-like	Mus musculus	99-103
32339784-6	2020	Our data revealed that LIEN alleviated DOX-induced cardiac dysfunction and apoptosis through inhibition of dynamin-related protein 1 (Drp1)-mediated excess (unchecked) mitochondrial fission.	Doxorubicin	39-42	dynamin 1-like	Mus musculus	107-132
32339784-6	2020	Our data revealed that LIEN alleviated DOX-induced cardiac dysfunction and apoptosis through inhibition of dynamin-related protein 1 (Drp1)-mediated excess (unchecked) mitochondrial fission.	Doxorubicin	39-42	dynamin 1-like	Mus musculus	134-138
32339784-8	2020	In DOX-challenged neonatal mouse ventricular myocytes (NMVMs), LIEN-suppressed Drp1 phosphorylation, mitochondrial fragmentation, and apoptosis were blunted by Rab7 overexpression, the effect of which was reversed by the ERK inhibitor U0126.	Doxorubicin	3-6	dynamin 1-like	Mus musculus	79-83
32339784-8	2020	In DOX-challenged neonatal mouse ventricular myocytes (NMVMs), LIEN-suppressed Drp1 phosphorylation, mitochondrial fragmentation, and apoptosis were blunted by Rab7 overexpression, the effect of which was reversed by the ERK inhibitor U0126.	U 0126	235-240	dynamin 1-like	Mus musculus	79-83
32526704-5	2020	Melatonin markedly alleviated PrP106-126-induced apoptosis of N2a cells, and inhibited PrP106-126-induced mitochondrial abnormality and dysfunction, including mitochondrial fragmentation and overproduction of reactive oxygen species (ROS), suppression of ATP, reduced mitochondrial membrane potential (MMP), and altered mitochondrial dynamic proteins dynamin-related protein 1 (DRP1) and optic atrophy protein 1 (OPA1).	Melatonin	0-9	dynamin 1-like	Mus musculus	351-376
32273259-5	2020	Mechanistically, Dox enhanced expressions of NOX1 and NOX4 and induced mitochondrial fission through dynamin-related protein 1 (Drp1) activation, leading to NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes via caspase-1-dependent manner.	Doxorubicin	17-20	dynamin 1-like	Mus musculus	101-126
32273259-5	2020	Mechanistically, Dox enhanced expressions of NOX1 and NOX4 and induced mitochondrial fission through dynamin-related protein 1 (Drp1) activation, leading to NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes via caspase-1-dependent manner.	Doxorubicin	17-20	dynamin 1-like	Mus musculus	128-132
32273259-6	2020	Conversely, both inhibitions of NOX1 and NOX4 and Drp1 suppressed Dox-induced NLPR3 inflammasome activation and pyroptosis.	Doxorubicin	66-69	dynamin 1-like	Mus musculus	50-54
32273259-8	2020	Importantly, Dox-induced Drp1-mediated mitochondrial fission and the consequent NLRP3 inflammasome activation and pyroptosis were reversed by NOX1 and NOX4 inhibition in mice.	Doxorubicin	13-16	dynamin 1-like	Mus musculus	25-29
32526704-5	2020	Melatonin markedly alleviated PrP106-126-induced apoptosis of N2a cells, and inhibited PrP106-126-induced mitochondrial abnormality and dysfunction, including mitochondrial fragmentation and overproduction of reactive oxygen species (ROS), suppression of ATP, reduced mitochondrial membrane potential (MMP), and altered mitochondrial dynamic proteins dynamin-related protein 1 (DRP1) and optic atrophy protein 1 (OPA1).	Melatonin	0-9	dynamin 1-like	Mus musculus	378-382
31896304-6	2020	Furthermore, HFD increased the protein level, phosphorylation (at the activating serine 616 site), oligomerization, mitochondrial translocation, and GTPase activity of Drp1 in mouse hearts, indicating that Drp1 was activated.	cholecystokinin C-terminal flanking peptide	81-87	dynamin 1-like	Mus musculus	206-210
32291286-6	2020	In the mouse model, PKCdelta was activated and accumulated in mitochondria, where it mediated phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616.	Serine	183-189	dynamin 1-like	Mus musculus	146-171
32291286-6	2020	In the mouse model, PKCdelta was activated and accumulated in mitochondria, where it mediated phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616.	Serine	183-189	dynamin 1-like	Mus musculus	173-177
32144179-7	2020	Functionally, deletion of Bbeta2 and maintained Drp1 Ser637 phosphorylation improved mitochondrial respiratory capacity, Ca2+ homeostasis, and attenuated superoxide production in response to ischemia and excitotoxicity in vitro and ex vivo Lastly, deletion of Bbeta2 rescued excessive stroke damage associated with dephosphorylation of Drp1 S637 and mitochondrial fission.	Superoxides	154-164	dynamin 1-like	Mus musculus	48-52
32641998-0	2020	Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment.	Indican	0-15	dynamin 1-like	Mus musculus	63-67
32641998-11	2020	Administration of AST-120 or genetic knockout of IRF1 attenuated IS-induced DRP1 reduction, mitophagic impairment and intestinal barrier injury in mice.	AST 120	18-25	dynamin 1-like	Mus musculus	76-80
31811407-5	2020	Carnitine palmitoyltransferase 1b (CPT1b), a rate-limiting enzyme of mitochondrial beta-oxidation in adult heart, was sharply decreased in LRP6 deficiency hearts, coincident with the activation of Drp1.	Carnitine	0-9	dynamin 1-like	Mus musculus	197-201
31811407-6	2020	Drp1 inhibitor greatly improved cardiac dysfunction and attenuated the increase in total fatty acids and fatty acids C16:0, C18:1n9 in LRP6 deficiency hearts.	Fatty Acids	89-100	dynamin 1-like	Mus musculus	0-4
31811407-6	2020	Drp1 inhibitor greatly improved cardiac dysfunction and attenuated the increase in total fatty acids and fatty acids C16:0, C18:1n9 in LRP6 deficiency hearts.	Fatty Acids	105-116	dynamin 1-like	Mus musculus	0-4
32008150-0	2020	Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice.	Methylene Blue	0-14	dynamin 1-like	Mus musculus	89-93
32008150-0	2020	Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice.	Sevoflurane	32-43	dynamin 1-like	Mus musculus	89-93
32008150-8	2020	Exposure to sevoflurane increased SENP3 expression and Drp1 deSUMOylation in the aged hippocampus and resulted in cognitive deficiency.	Sevoflurane	12-23	dynamin 1-like	Mus musculus	55-59
32008150-10	2020	This neuroprotective effect provides a mechanistic explanation for how the SUMOylation status of Drp1 acts as a key switch in the cognitive dysfunction induced by sevoflurane.	Sevoflurane	163-174	dynamin 1-like	Mus musculus	97-101
31896304-7	2020	Monkeys fed a diet high in fat and cholesterol for 2.5 years also exhibited myocardial damage and Drp1 activation in the heart.	Cholesterol	35-46	dynamin 1-like	Mus musculus	98-102
31896304-9	2020	In adult cardiomyocytes, palmitate increased Drp1 acetylation, phosphorylation, and protein levels, and these increases were abolished by restoration of the decreased NAD+ level.	Palmitates	25-34	dynamin 1-like	Mus musculus	45-49
31896304-10	2020	Proteomics analysis and in vitro screening revealed that Drp1 acetylation at lysine 642 (K642) was increased by HFD in mouse hearts and by palmitate incubation in cardiomyocytes.	tyrosyl-lysine	77-83	dynamin 1-like	Mus musculus	57-61
31896304-10	2020	Proteomics analysis and in vitro screening revealed that Drp1 acetylation at lysine 642 (K642) was increased by HFD in mouse hearts and by palmitate incubation in cardiomyocytes.	Palmitates	139-148	dynamin 1-like	Mus musculus	57-61
31896304-11	2020	The non-acetylated Drp1 mutation (K642R) attenuated palmitate-induced Drp1 activation, its interaction with voltage-dependent anion channel 1, mitochondrial fission, contractile dysfunction, and cardiomyocyte death.	Palmitates	52-61	dynamin 1-like	Mus musculus	19-23
31896304-11	2020	The non-acetylated Drp1 mutation (K642R) attenuated palmitate-induced Drp1 activation, its interaction with voltage-dependent anion channel 1, mitochondrial fission, contractile dysfunction, and cardiomyocyte death.	Palmitates	52-61	dynamin 1-like	Mus musculus	70-74
31881179-3	2020	Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss.	Serine	210-216	dynamin 1-like	Mus musculus	26-51
30990365-4	2020	Exposure of microglia to cocaine also resulted in increased expression of DNM1L and OPTN with a concomitant decrease in the rate of mitochondrial oxygen consumption as well as impaired mitochondrial functioning.	Cocaine	25-32	dynamin 1-like	Mus musculus	74-79
31753492-4	2020	Moreover, further studies identified that MC-LR induced mitochondrial fragmentation via activating Dynamin-related protein 1 (Drp1) and Mitochondrial fission factor (Mff), contributing to apoptosis of hippocampal neuronal cells.	mc-lr	42-47	dynamin 1-like	Mus musculus	99-124
31753492-4	2020	Moreover, further studies identified that MC-LR induced mitochondrial fragmentation via activating Dynamin-related protein 1 (Drp1) and Mitochondrial fission factor (Mff), contributing to apoptosis of hippocampal neuronal cells.	mc-lr	42-47	dynamin 1-like	Mus musculus	126-130
31881179-3	2020	Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss.	Serine	210-216	dynamin 1-like	Mus musculus	52-56
32298841-6	2020	RESULTS: Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control.	dss	51-54	dynamin 1-like	Mus musculus	145-149
31954373-0	2020	Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock.	ros	38-41	dynamin 1-like	Mus musculus	10-14
31954373-6	2020	Together, these data suggest that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock.	Fatty Acids, Volatile	92-96	dynamin 1-like	Mus musculus	34-38
31954373-6	2020	Together, these data suggest that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock.	ros	113-116	dynamin 1-like	Mus musculus	34-38
32298841-6	2020	RESULTS: Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control.	dss	51-54	dynamin 1-like	Mus musculus	216-220
31574344-9	2019	Furthermore, mitochondrial fission and protein expression of mitochondrial dynamics (Mfn2 [mitofusin 2], OPA1 [optic atrophy 1], Drp1 [dynamin-related protein 1] and Fis-1 [fission 1]) was detected by mitotracker green staining and western blot, respectively.	mitotracker	201-212	dynamin 1-like	Mus musculus	135-160
31914595-5	2020	Parallel studies revealed that fission-defective Drp1 knockout hearts and MEFs evoked stronger mitochondrial enlargement, enhanced mitophagy with mitochondrial volume decrease and increased mitochondrial calcium uptake, superoxide production, and permeability transition pore opening, contributed to cardiomyocyte apoptosis and dilated cardiomyopathy.	Calcium	204-211	dynamin 1-like	Mus musculus	49-53
31914595-5	2020	Parallel studies revealed that fission-defective Drp1 knockout hearts and MEFs evoked stronger mitochondrial enlargement, enhanced mitophagy with mitochondrial volume decrease and increased mitochondrial calcium uptake, superoxide production, and permeability transition pore opening, contributed to cardiomyocyte apoptosis and dilated cardiomyopathy.	Superoxides	220-230	dynamin 1-like	Mus musculus	49-53
31914641-6	2020	In silico screening identified an ellipticine compound, Drpitor1, as a putative, potent Drp1 inhibitor.	ellipticine	34-45	dynamin 1-like	Mus musculus	88-92
31781748-0	2019	Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation.	Quercetin	0-9	dynamin 1-like	Mus musculus	79-83
31781748-0	2019	Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation.	Serine	103-109	dynamin 1-like	Mus musculus	79-83
31781748-5	2019	In addition, western blot analysis showed that quercetin treatment suppressed the levels of dynamin-related protein 1 (Drp1) and phosphorylation at serine 616 in endothelial cells of obese mice.	Quercetin	47-56	dynamin 1-like	Mus musculus	92-117
31781748-5	2019	In addition, western blot analysis showed that quercetin treatment suppressed the levels of dynamin-related protein 1 (Drp1) and phosphorylation at serine 616 in endothelial cells of obese mice.	Quercetin	47-56	dynamin 1-like	Mus musculus	119-123
31781748-6	2019	Mechanistically, quercetin specifically suppressed Drp1 phosphorylation at serine 616, whereas it showed little effects on the Drp1 level and its phosphorylation at serine 637 in cultured endothelial cells under oxidative stress.	Quercetin	17-26	dynamin 1-like	Mus musculus	51-55
31781748-6	2019	Mechanistically, quercetin specifically suppressed Drp1 phosphorylation at serine 616, whereas it showed little effects on the Drp1 level and its phosphorylation at serine 637 in cultured endothelial cells under oxidative stress.	Serine	75-81	dynamin 1-like	Mus musculus	51-55
31781748-7	2019	Furthermore, our results also showed that quercetin suppressed Drp1 phosphorylation at serine 616 by inhibiting PKCdelta as revealed by western blot analysis.	Quercetin	42-51	dynamin 1-like	Mus musculus	63-67
31781748-7	2019	Furthermore, our results also showed that quercetin suppressed Drp1 phosphorylation at serine 616 by inhibiting PKCdelta as revealed by western blot analysis.	Serine	87-93	dynamin 1-like	Mus musculus	63-67
31839999-0	2019	DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy.	Ethanol	18-25	dynamin 1-like	Mus musculus	62-66
31377418-4	2019	We used animal model of experimental autoimmune encephalomyelitis (EAE) and tested whether ONOO- mediates Drp1 assembly in mitochondria for mitophagy and aggravates MS pathology.	onoo	91-95	dynamin 1-like	Mus musculus	106-110
31510791-9	2019	Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3.	4-hydroxy-2-nonenal	11-27	dynamin 1-like	Mus musculus	113-117
31510791-9	2019	Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3.	4-hydroxy-2-nonenal	11-27	dynamin 1-like	Mus musculus	119-144
31510791-9	2019	Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3.	Serine	149-155	dynamin 1-like	Mus musculus	113-117
31510791-9	2019	Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3.	Serine	149-155	dynamin 1-like	Mus musculus	119-144
31377418-6	2019	Importantly, increased ONOO- production was companied with Drp1 mitochondrial recruitment, PINK1/Parkin-mediated mitophagy, axonal degeneration and neuronal cell death, which were reversed by peroxynitrite decomposition catalyst (PDC).	onoo	23-27	dynamin 1-like	Mus musculus	59-63
31377418-6	2019	Importantly, increased ONOO- production was companied with Drp1 mitochondrial recruitment, PINK1/Parkin-mediated mitophagy, axonal degeneration and neuronal cell death, which were reversed by peroxynitrite decomposition catalyst (PDC).	Peroxynitrous Acid	192-205	dynamin 1-like	Mus musculus	59-63
31377418-7	2019	Furthermore, ONOO- production induced Drp1 nitration, promoted Drp1 assembly and mitochondrial recruitment for mitophagy activation, contributing to the EAE pathology.	onoo	13-17	dynamin 1-like	Mus musculus	38-42
31377418-7	2019	Furthermore, ONOO- production induced Drp1 nitration, promoted Drp1 assembly and mitochondrial recruitment for mitophagy activation, contributing to the EAE pathology.	onoo	13-17	dynamin 1-like	Mus musculus	63-67
31377418-8	2019	Together, we conclude that ONOO- serves as a key mediator in Drp1 nitration modification and assembly for facilitating mitophagy activation.	onoo	27-31	dynamin 1-like	Mus musculus	61-65
31377418-9	2019	Targeting ONOO--mediated Drp1 assembly and mitochondrial recruitment could be an important therapeutic strategy for multiple sclerosis treatment.	onoo	10-14	dynamin 1-like	Mus musculus	25-29
31578315-5	2019	Importantly, we found that ROCK1 was activated in an MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632 blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1 dephosphorylation/activation.	1-(4-methoxyphenyl)pyridinium	53-57	dynamin 1-like	Mus musculus	165-169
31238056-5	2019	Further mechanism studies showed that tBCCAO induced mitochondrial oxidative stress injuries and triggered mitochondrial fragmentation, which were evident by the elevated levels of malondialdehyde and mitochondrial dynamin-related protein 1 (Drp1) and the downregulated activities of superoxide dismutase and nuclear transcription factor E2-related factor 2 (Nrf2).	tbccao	38-44	dynamin 1-like	Mus musculus	215-240
31238056-5	2019	Further mechanism studies showed that tBCCAO induced mitochondrial oxidative stress injuries and triggered mitochondrial fragmentation, which were evident by the elevated levels of malondialdehyde and mitochondrial dynamin-related protein 1 (Drp1) and the downregulated activities of superoxide dismutase and nuclear transcription factor E2-related factor 2 (Nrf2).	tbccao	38-44	dynamin 1-like	Mus musculus	242-246
31578315-5	2019	Importantly, we found that ROCK1 was activated in an MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632 blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1 dephosphorylation/activation.	1-(4-methoxyphenyl)pyridinium	53-57	dynamin 1-like	Mus musculus	267-271
31578315-5	2019	Importantly, we found that ROCK1 was activated in an MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632 blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1 dephosphorylation/activation.	Y 27632	149-156	dynamin 1-like	Mus musculus	165-169
31578315-5	2019	Importantly, we found that ROCK1 was activated in an MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632 blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1 dephosphorylation/activation.	Y 27632	149-156	dynamin 1-like	Mus musculus	267-271
31578315-6	2019	Our in vivo study confirmed that Y-27632 significantly improved symptoms in a PD mouse model by inhibiting Drp1-mediated aberrant mitochondrial fission and apoptosis.	Y 27632	33-40	dynamin 1-like	Mus musculus	107-111
30553835-0	2019	Dynamin-1-Like Protein Inhibition Drives Megamitochondria Formation as an Adaptive Response in Alcohol-Induced Hepatotoxicity.	Alcohols	95-102	dynamin 1-like	Mus musculus	0-22
31291545-9	2019	Moreover, DRP1-deficient mice were protected from Dox-induced cardiac damage, strongly supporting a role for DRP1-dependent mitochondrial fragmentation in Dox cardiotoxicity.	Doxorubicin	50-53	dynamin 1-like	Mus musculus	10-14
31291545-9	2019	Moreover, DRP1-deficient mice were protected from Dox-induced cardiac damage, strongly supporting a role for DRP1-dependent mitochondrial fragmentation in Dox cardiotoxicity.	Doxorubicin	50-53	dynamin 1-like	Mus musculus	109-113
31291545-9	2019	Moreover, DRP1-deficient mice were protected from Dox-induced cardiac damage, strongly supporting a role for DRP1-dependent mitochondrial fragmentation in Dox cardiotoxicity.	Doxorubicin	155-158	dynamin 1-like	Mus musculus	10-14
31291545-9	2019	Moreover, DRP1-deficient mice were protected from Dox-induced cardiac damage, strongly supporting a role for DRP1-dependent mitochondrial fragmentation in Dox cardiotoxicity.	Doxorubicin	155-158	dynamin 1-like	Mus musculus	109-113
31291545-10	2019	In addition, Dox accelerated mitophagy flux, which was attenuated by DRP1 knockdown, as assessed by the mitophagy reporter mt-Rosella, suggesting the necessity of mitochondrial fragmentation in Dox-induced mitophagy.	Doxorubicin	13-16	dynamin 1-like	Mus musculus	69-73
31291545-10	2019	In addition, Dox accelerated mitophagy flux, which was attenuated by DRP1 knockdown, as assessed by the mitophagy reporter mt-Rosella, suggesting the necessity of mitochondrial fragmentation in Dox-induced mitophagy.	Doxorubicin	194-197	dynamin 1-like	Mus musculus	69-73
30390091-7	2019	Treatment of SOD2-/- neurons with the Ca2+ chelator BAPTA-AM significantly increases levels of phosphorylated Drp1, reduces mitochondrial fragmentation and enables neurite outgrowth.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	52-60	dynamin 1-like	Mus musculus	110-114
31168914-8	2019	Mechanistically, CGA attenuates ROS-induced mitochondrial fragmentation by inhibiting dynamin-related protein 1 (Drp1) and enhancing Mfn2 expression.	Reactive Oxygen Species	32-35	dynamin 1-like	Mus musculus	86-111
31168914-8	2019	Mechanistically, CGA attenuates ROS-induced mitochondrial fragmentation by inhibiting dynamin-related protein 1 (Drp1) and enhancing Mfn2 expression.	Reactive Oxygen Species	32-35	dynamin 1-like	Mus musculus	113-117
31063459-4	2019	We found that diabetic Drp1S600A mice exhibited improved biochemical and histological features of DN along with reduced mitochondrial fission and diminished mitochondrial ROS in vivo.	ros	171-174	dynamin 1-like	Mus musculus	23-27
31063459-6	2019	Mechanistically, we showed that mitochondrial fission in high glucose conditions occurs through concomitant binding of phospho-Drp1S600 with mitochondrial fission factor (Mff) and actin-related protein 3 (Arp3), ultimately leading to accumulation of F-actin and Drp1 on the mitochondria.	Glucose	62-69	dynamin 1-like	Mus musculus	127-131
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Glutamic Acid	14-23	dynamin 1-like	Mus musculus	116-141
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Glutamic Acid	14-23	dynamin 1-like	Mus musculus	143-147
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Reactive Oxygen Species	51-74	dynamin 1-like	Mus musculus	116-141
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Reactive Oxygen Species	51-74	dynamin 1-like	Mus musculus	143-147
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Reactive Oxygen Species	76-79	dynamin 1-like	Mus musculus	116-141
31358548-3	2019	A hallmark of glutamate toxicity is high levels of reactive oxygen species (ROS), which can trigger Ca2+ influx and dynamin related-protein 1 (Drp1)-mediated mitochondrial fission.	Reactive Oxygen Species	76-79	dynamin 1-like	Mus musculus	143-147
31358548-7	2019	We found that glutamate treatment induces endogenous Prx5 expression and Ca2+/calcineurin-dependent de-phosphorylation of Drp1, resulting in mitochondrial fission and neuronal cell death.	Glutamic Acid	14-23	dynamin 1-like	Mus musculus	122-126
31358548-8	2019	Our results indicate that Prx5 inhibits glutamate-induced mitochondrial fission through the regulation of Ca2+/calcineurin-dependent de-phosphorylation of Drp1, and it does so by scavenging cytosolic and mitochondrial ROS.	Glutamic Acid	40-49	dynamin 1-like	Mus musculus	155-159
30940514-11	2019	In vivo, 12-week SAG treatment also inhibited the apoptosis of hippocampal neurons in HFD-fed mice by increasing mitofusin 2 (Mfn2) and B-cell lymphoma 2 (Bcl-2) levels and decreasing dynamin-related protein 1 (Drp1) and Bcl-2 homologous antagonist/killer (Bak) levels.	sagopilone	17-20	dynamin 1-like	Mus musculus	184-209
30940514-11	2019	In vivo, 12-week SAG treatment also inhibited the apoptosis of hippocampal neurons in HFD-fed mice by increasing mitofusin 2 (Mfn2) and B-cell lymphoma 2 (Bcl-2) levels and decreasing dynamin-related protein 1 (Drp1) and Bcl-2 homologous antagonist/killer (Bak) levels.	sagopilone	17-20	dynamin 1-like	Mus musculus	211-215
30993548-0	2019	Divergent Expression Patterns of Drp1 and HSD10 in the Nigro-Striatum of Two Mice Strains Based on their MPTP Susceptibility.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	105-109	dynamin 1-like	Mus musculus	33-37
30894684-10	2019	Depleting cytosolic mtDNA using DNase I or blocking TLR9 pathway by TLR9 antagonist, siRNA for TLR9 or p65 in HCC cells with Drp1 overexpression significantly decreased the recruitment and polarization of TAMs.	tams	205-209	dynamin 1-like	Mus musculus	125-129
29890853-10	2019	Inhibiting the activity of Rho-associated coiled-coil containing protein kinase (ROCK) by Y-27632 attenuated phosphorylation of Drp1 ser656 and mitochondrial fragmentation in Numb-deficient cells.	Y 27632	90-97	dynamin 1-like	Mus musculus	128-132
29890853-12	2019	Innovation and Conclusion: Our data suggest that Numb depletion promotes mitochondrial fragmentation by promoting the phosphorylation of Drp1 Ser637 and thus exacerbates cisplatin-induced mitochondrial dysfunction and tubular cell apoptosis.	Cisplatin	170-179	dynamin 1-like	Mus musculus	137-141
30659828-3	2019	In this study, we investigated whether Drp1 translocation to mitochondria was implicated in HIR induced hippocampus injury in young mice, and further detected the role of calcineurin in the regulation of mitochondrial dynamics.	N(tau)-ribosylhistidine	92-95	dynamin 1-like	Mus musculus	39-43
30659828-10	2019	HIR induced increased expression of calcineurin and dephosphorylation of Drp1 at Ser637 in hippocampus.	N(tau)-ribosylhistidine	0-3	dynamin 1-like	Mus musculus	73-77
30659828-11	2019	Treatment with Mdivi-1 and FK506 upregulated the phosphorylation of Drp1, inhibited Drp1 translocation to mitochondria, and alleviated mitochondrial fragmentation after HIR.	Tacrolimus	27-32	dynamin 1-like	Mus musculus	68-72
30659828-11	2019	Treatment with Mdivi-1 and FK506 upregulated the phosphorylation of Drp1, inhibited Drp1 translocation to mitochondria, and alleviated mitochondrial fragmentation after HIR.	Tacrolimus	27-32	dynamin 1-like	Mus musculus	84-88
30659828-13	2019	These data suggest that calcineurin mediated Drp1 dephosphorylation and translocation to mitochondria play a crucial role in HIR induced mitochondrial fragmentation and neurons apoptosis in hippocampus.	N(tau)-ribosylhistidine	125-128	dynamin 1-like	Mus musculus	45-49
30553835-6	2019	Dynamin-1-like protein (Drp1) was identified as the main mediator driving these mitochondrial alterations, and its genetic inactivation was determined to foster megamitochondria development, preserving the capacity of the cells to grow despite alcohol toxicity.	Alcohols	244-251	dynamin 1-like	Mus musculus	0-22
30553835-6	2019	Dynamin-1-like protein (Drp1) was identified as the main mediator driving these mitochondrial alterations, and its genetic inactivation was determined to foster megamitochondria development, preserving the capacity of the cells to grow despite alcohol toxicity.	Alcohols	244-251	dynamin 1-like	Mus musculus	24-28
30553835-10	2019	Our study demonstrates that megamitochondria formation is mediated by Drp1, and this phenomenon is a beneficial adaptive response during alcohol-induced hepatotoxicity.	Alcohols	137-144	dynamin 1-like	Mus musculus	70-74
30093535-6	2018	Our results indicate that inhibition of Drp1-dependent mitochondrial fission by the outer mitochondrial AKAP1/PKA complex protects neurons from ischemic stroke by maintaining respiratory chain activity, inhibiting superoxide production, and delaying Ca2+ deregulation.	Superoxides	214-224	dynamin 1-like	Mus musculus	40-44
30516433-0	2019	Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.	Guanosine Triphosphate	34-37	dynamin 1-like	Mus musculus	29-33
30516433-3	2019	This study finds that cyclin C directly interacts with the Drp1 GTPase domain, increases its affinity to GTP, and stimulates GTPase activity in vitro.	Guanosine Triphosphate	64-67	dynamin 1-like	Mus musculus	59-63
30691497-0	2019	Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone.	cryptotanshinone	114-130	dynamin 1-like	Mus musculus	14-39
30380511-8	2018	RESULTS: Therapy with 2% H2 increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis.	Hydrogen	25-27	dynamin 1-like	Mus musculus	157-161
31037132-0	2019	Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction.	Berberine	0-9	dynamin 1-like	Mus musculus	55-59
31037132-6	2019	Mechanistically, BBR could stabilize mitochondrial morphology in podocytes via abolishing palmitic acid (PA)-induced activation of dynamin-related protein 1 (Drp1).	Palmitic Acid	90-103	dynamin 1-like	Mus musculus	131-156
31037132-6	2019	Mechanistically, BBR could stabilize mitochondrial morphology in podocytes via abolishing palmitic acid (PA)-induced activation of dynamin-related protein 1 (Drp1).	Palmitic Acid	90-103	dynamin 1-like	Mus musculus	158-162
31037132-6	2019	Mechanistically, BBR could stabilize mitochondrial morphology in podocytes via abolishing palmitic acid (PA)-induced activation of dynamin-related protein 1 (Drp1).	Palmitic Acid	105-107	dynamin 1-like	Mus musculus	131-156
31037132-6	2019	Mechanistically, BBR could stabilize mitochondrial morphology in podocytes via abolishing palmitic acid (PA)-induced activation of dynamin-related protein 1 (Drp1).	Palmitic Acid	105-107	dynamin 1-like	Mus musculus	158-162
30404834-6	2018	The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane.	Serine	81-84	dynamin 1-like	Mus musculus	65-69
30404834-6	2018	The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane.	Serine	81-84	dynamin 1-like	Mus musculus	71-76
30404834-6	2018	The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane.	Serine	81-84	dynamin 1-like	Mus musculus	131-135
30285293-15	2018	Synaptic transmission defects could be partially rescued with EGTA-AM, indicating close coupling of Ca2+ channels to SV distance normally found in mature terminals may be compromised by DRP1-preKO.	EGTA acetoxymethyl ester	62-69	dynamin 1-like	Mus musculus	186-190
30425165-3	2018	Here, we report that the actin-binding protein filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission-associated myocardial senescence in mice after MI.	Guanine Nucleotides	68-86	dynamin 1-like	Mus musculus	107-111
30093535-10	2018	Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca2+ overload result from genetic disinhibition of Drp1.	Superoxides	71-81	dynamin 1-like	Mus musculus	149-153
30275767-7	2018	Mitochondrial fission, measured by phosphorylated dynamin-related protein 1 (p-DRP1) and fission protein 1 (FIS1) expression, also decreased following CoCl2 exposure, and was stabilized by B355252 addition.	cobaltous chloride	151-156	dynamin 1-like	Mus musculus	50-75
29575122-8	2018	In contrast, SIRT1 or PGC-1alpha siRNA knockdown blunted the inhibitory effects of melatonin on Drp1 expression and mitochondrial fission.	Melatonin	83-92	dynamin 1-like	Mus musculus	96-100
29575122-5	2018	Here, we show that melatonin prevented diabetes-induced cardiac dysfunction by inhibiting dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.	Melatonin	19-28	dynamin 1-like	Mus musculus	90-115
29575122-5	2018	Here, we show that melatonin prevented diabetes-induced cardiac dysfunction by inhibiting dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.	Melatonin	19-28	dynamin 1-like	Mus musculus	117-121
29575122-9	2018	These data indicated that melatonin exerted its cardioprotective effects by reducing Drp1-mediated mitochondrial fission in a SIRT1/PGC-1alpha-dependent manner.	Melatonin	26-35	dynamin 1-like	Mus musculus	85-89
29575122-6	2018	Melatonin treatment decreased Drp1 expression, inhibited mitochondrial fragmentation, suppressed oxidative stress, reduced cardiomyocyte apoptosis, improved mitochondrial function and cardiac function in streptozotocin (STZ)-induced diabetic mice, but not in SIRT1-/- diabetic mice.	Melatonin	0-9	dynamin 1-like	Mus musculus	30-34
29575122-12	2018	These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly.	Melatonin	25-34	dynamin 1-like	Mus musculus	216-220
28448247-6	2018	In addition, glutamate induced an increase in dephosphorylation of dynamin-related protein 1 (Drp1), mitochondrial fragmentation, and mitochondrial dysfunction.	Glutamic Acid	13-22	dynamin 1-like	Mus musculus	67-92
28448247-6	2018	In addition, glutamate induced an increase in dephosphorylation of dynamin-related protein 1 (Drp1), mitochondrial fragmentation, and mitochondrial dysfunction.	Glutamic Acid	13-22	dynamin 1-like	Mus musculus	94-98
28448247-8	2018	Furthermore, Ole amended a glutamate-induced mitochondrial dynamic imbalance and reduced the number of cells with fragmented mitochondria, regulating the phosphorylation of Drp1 at amino acid residue serine 637.	Glutamic Acid	27-36	dynamin 1-like	Mus musculus	173-177
28448247-8	2018	Furthermore, Ole amended a glutamate-induced mitochondrial dynamic imbalance and reduced the number of cells with fragmented mitochondria, regulating the phosphorylation of Drp1 at amino acid residue serine 637.	Serine	200-206	dynamin 1-like	Mus musculus	173-177
29397067-5	2018	Drp1 phosphorylation at serine 616 is increased in HD knock-in mouse derived striatal cells, which is abolished by treatment with U0126, a potent inhibitor of MEK1/2.	Serine	24-30	dynamin 1-like	Mus musculus	0-4
29673648-6	2018	However, inhibition of Drp1 by Mdivi1 (Drp1 inhibitor) resulted in higher OxPhos ATP production and lower mitochondrial membrane potential.	Adenosine Triphosphate	81-84	dynamin 1-like	Mus musculus	23-27
29673648-6	2018	However, inhibition of Drp1 by Mdivi1 (Drp1 inhibitor) resulted in higher OxPhos ATP production and lower mitochondrial membrane potential.	Adenosine Triphosphate	81-84	dynamin 1-like	Mus musculus	39-43
29867110-3	2018	The results showed that extracellular succinate promoted the translocation of dynamin-related protein 1 (Drp1) to mitochondria via protein kinase Cdelta (PKCdelta) activation, and induced mitochondrial fission factor (MFF) phosphorylation via extracellular signal-regulated kinases-1/2 (ERK1/2) activation in a GPR91-dependent manner.	Succinic Acid	38-47	dynamin 1-like	Mus musculus	78-103
29867110-3	2018	The results showed that extracellular succinate promoted the translocation of dynamin-related protein 1 (Drp1) to mitochondria via protein kinase Cdelta (PKCdelta) activation, and induced mitochondrial fission factor (MFF) phosphorylation via extracellular signal-regulated kinases-1/2 (ERK1/2) activation in a GPR91-dependent manner.	Succinic Acid	38-47	dynamin 1-like	Mus musculus	105-109
29853636-7	2018	Drp1ABCD assembles onto these membranes in a manner that is regulated by its oligomerization and GTP hydrolysis.	Guanosine Triphosphate	97-100	dynamin 1-like	Mus musculus	0-4
29225119-8	2018	Meanwhile, in HFD-fed mice and PA-induced cells, TBBE regulated Drp1 phosphorylation and inhibited its activation, implying the protective effect of TBBE on mitochondrial morphology.	Palmitic Acid	31-33	dynamin 1-like	Mus musculus	64-68
29225119-8	2018	Meanwhile, in HFD-fed mice and PA-induced cells, TBBE regulated Drp1 phosphorylation and inhibited its activation, implying the protective effect of TBBE on mitochondrial morphology.	tbbe	49-53	dynamin 1-like	Mus musculus	64-68
29225119-8	2018	Meanwhile, in HFD-fed mice and PA-induced cells, TBBE regulated Drp1 phosphorylation and inhibited its activation, implying the protective effect of TBBE on mitochondrial morphology.	tbbe	149-153	dynamin 1-like	Mus musculus	64-68
29662437-8	2018	The in vitro study showed BHB (10 mM) prevented the mitochondrial translocation of dynamin-related protein 1 (Drp1) to inhibit mitochondrial fission.	3-Hydroxybutyric Acid	26-29	dynamin 1-like	Mus musculus	83-108
29662437-8	2018	The in vitro study showed BHB (10 mM) prevented the mitochondrial translocation of dynamin-related protein 1 (Drp1) to inhibit mitochondrial fission.	3-Hydroxybutyric Acid	26-29	dynamin 1-like	Mus musculus	110-114
29397067-5	2018	Drp1 phosphorylation at serine 616 is increased in HD knock-in mouse derived striatal cells, which is abolished by treatment with U0126, a potent inhibitor of MEK1/2.	U 0126	130-135	dynamin 1-like	Mus musculus	0-4
29084809-3	2018	Using genetic murine models, we found that proximal tubule-specific deletion of Drp1 prevented the renal ischemia-reperfusion-induced kidney injury, inflammation, and programmed cell death observed in wild-type mice and promoted epithelial recovery, which associated with activation of the renoprotective beta-hydroxybutyrate signaling pathway.	3-Hydroxybutyric Acid	305-325	dynamin 1-like	Mus musculus	80-84
29166700-5	2018	Suppression of DLP1 expression by DPL1 RNAi inhibited prion-induced mitochondrial fragmentation and dysfunction (measured by ADP/ATP ratio, mitochondrial membrane potential, and mitochondrial integrity).	Adenosine Diphosphate	125-128	dynamin 1-like	Mus musculus	15-19
29166700-5	2018	Suppression of DLP1 expression by DPL1 RNAi inhibited prion-induced mitochondrial fragmentation and dysfunction (measured by ADP/ATP ratio, mitochondrial membrane potential, and mitochondrial integrity).	Adenosine Triphosphate	129-132	dynamin 1-like	Mus musculus	15-19
29209146-8	2017	Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616).	Serine	141-147	dynamin 1-like	Mus musculus	102-106
29209146-8	2017	Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616).	Serine	141-147	dynamin 1-like	Mus musculus	155-159
29209146-8	2017	Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616).	Serine	141-147	dynamin 1-like	Mus musculus	161-171
28942921-4	2017	We show here that uptake of multiple ACs by macrophages requires dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake.	Charcoal	37-39	dynamin 1-like	Mus musculus	65-90
28942921-4	2017	We show here that uptake of multiple ACs by macrophages requires dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake.	Charcoal	37-39	dynamin 1-like	Mus musculus	92-96
28942921-7	2017	Mice lacking myeloid Drp1 showed defective efferocytosis and its pathologic consequences in the thymus after dexamethasone treatment and in advanced atherosclerotic lesions in fat-fed Ldlr-/- mice.	Dexamethasone	109-122	dynamin 1-like	Mus musculus	21-25
28981117-7	2017	Trehalose could ameliorate oxidative stress-mediated mitochondrial membrane potential collapse, ATP level decrease, dynamin-related protein 1 (drp-1) translocation into the mitochondria, and the upregulation of proteins involved in mitochondria and endoplasmic reticulum (ER) stress-related apoptosis pathway.	Trehalose	0-9	dynamin 1-like	Mus musculus	116-141
28981117-7	2017	Trehalose could ameliorate oxidative stress-mediated mitochondrial membrane potential collapse, ATP level decrease, dynamin-related protein 1 (drp-1) translocation into the mitochondria, and the upregulation of proteins involved in mitochondria and endoplasmic reticulum (ER) stress-related apoptosis pathway.	Trehalose	0-9	dynamin 1-like	Mus musculus	143-148
28849115-8	2017	Inhibition of Drp1 activity by Mdivi-1 efficiently prevented Abeta-42-induced ROS production and disruption of mitochondrial membrane potential.	Reactive Oxygen Species	78-81	dynamin 1-like	Mus musculus	14-18
28383775-0	2017	Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression.	polydatin	0-9	dynamin 1-like	Mus musculus	86-90
28398674-8	2017	However, melatonin strengthened CMEC survival via activation of AMPKalpha, followed by p-Drp1S616 downregulation and p-Drp1S37 upregulation, which blunted Drp1-dependent mitochondrial fission.	Melatonin	9-18	dynamin 1-like	Mus musculus	89-93
28634116-5	2017	Knockdown of Akt2 with siRNA diminished the effect of kaempferol, indicating that kaempferol suppressed dynamin-related protein 1 (Drp1) activation and promoted HK-II mitochondrial binding dependently on Akt.	kaempferol	82-92	dynamin 1-like	Mus musculus	104-129
28634116-5	2017	Knockdown of Akt2 with siRNA diminished the effect of kaempferol, indicating that kaempferol suppressed dynamin-related protein 1 (Drp1) activation and promoted HK-II mitochondrial binding dependently on Akt.	kaempferol	82-92	dynamin 1-like	Mus musculus	131-135
28634116-8	2017	This study indicates that succinate accumulation plays a pivotal role in I/R injury-induced neuronal mitochondrial dysfunction, and suggests that modulation of Drp1 phosphorylation might be potential therapeutic strategy to protect neuron mitochondrial integrity and treat ischemic stroke.	Succinic Acid	26-35	dynamin 1-like	Mus musculus	160-164
28282614-0	2017	Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice.	senecionine	36-47	dynamin 1-like	Mus musculus	14-18
28238799-2	2017	Here we show that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, is activated in primary OL cells exposed to TNF-alpha induced inflammation or oxidative stress, as well as in EAE-immunized and cuprizone toxicity-induced demyelinating mouse models.	Cuprizone	213-222	dynamin 1-like	Mus musculus	18-43
28314909-2	2017	Drp1 completes the fission process with GTP hydrolysis by its own GTPase activity.	Guanosine Triphosphate	40-43	dynamin 1-like	Mus musculus	0-4
28282614-10	2017	Pharmacological inhibition of dynamin-related protein1 (Drp1), a protein that is critical to regulate mitochondrial fission, blocked senecionine-induced mitochondrial fragmentation and mitochondrial release of cytochrome c and apoptosis.	senecionine	133-144	dynamin 1-like	Mus musculus	30-54
28282614-10	2017	Pharmacological inhibition of dynamin-related protein1 (Drp1), a protein that is critical to regulate mitochondrial fission, blocked senecionine-induced mitochondrial fragmentation and mitochondrial release of cytochrome c and apoptosis.	senecionine	133-144	dynamin 1-like	Mus musculus	56-60
28282614-11	2017	More importantly, hepatocyte-specific Drp1 knockout mice were resistant to senecionine-induced liver injury due to decreased mitochondrial damage and apoptosis.	senecionine	75-86	dynamin 1-like	Mus musculus	38-42
28282614-12	2017	In conclusion, our results uncovered a novel mechanism of Drp1-mediated mitochondrial fragmentation in senecionine-induced liver injury.	senecionine	103-114	dynamin 1-like	Mus musculus	58-62
28282614-13	2017	Targeting Drp1-mediated mitochondrial fragmentation and apoptosis may be a potential avenue to prevent and treat hepatotoxicity induced by PAs.	Pyrrolizidine Alkaloids	139-142	dynamin 1-like	Mus musculus	10-14
28560384-0	2017	Hydrogen sulfide inhibits mitochondrial fission in neuroblastoma N2a cells through the Drp1/ERK1/2 signaling pathway.	Hydrogen Sulfide	0-16	dynamin 1-like	Mus musculus	87-91
28560384-7	2017	To further understand the effects of H2S on mitochondrial morphology, the protein and mRNA expression levels of dynamin 1 like (Dnm1l, also known as Drp1) were examined, and the results demonstrated that NaHS dose-dependently reduced Drp1 mRNA and protein levels, consistent with the mitochondrial morphology changes.	sodium bisulfide	204-208	dynamin 1-like	Mus musculus	112-126
28560384-7	2017	To further understand the effects of H2S on mitochondrial morphology, the protein and mRNA expression levels of dynamin 1 like (Dnm1l, also known as Drp1) were examined, and the results demonstrated that NaHS dose-dependently reduced Drp1 mRNA and protein levels, consistent with the mitochondrial morphology changes.	sodium bisulfide	204-208	dynamin 1-like	Mus musculus	128-133
28560384-7	2017	To further understand the effects of H2S on mitochondrial morphology, the protein and mRNA expression levels of dynamin 1 like (Dnm1l, also known as Drp1) were examined, and the results demonstrated that NaHS dose-dependently reduced Drp1 mRNA and protein levels, consistent with the mitochondrial morphology changes.	sodium bisulfide	204-208	dynamin 1-like	Mus musculus	149-153
28560384-7	2017	To further understand the effects of H2S on mitochondrial morphology, the protein and mRNA expression levels of dynamin 1 like (Dnm1l, also known as Drp1) were examined, and the results demonstrated that NaHS dose-dependently reduced Drp1 mRNA and protein levels, consistent with the mitochondrial morphology changes.	sodium bisulfide	204-208	dynamin 1-like	Mus musculus	234-238
28560384-9	2017	It was observed that Drp1 overexpression reversed the effects of NaHS.	sodium bisulfide	65-69	dynamin 1-like	Mus musculus	21-25
28560384-10	2017	Furthermore, NaHS promoted the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, and the effects of NaHS on Drp1 expression were abolished by an ERK1/2 inhibitor (PD98059).	sodium bisulfide	118-122	dynamin 1-like	Mus musculus	126-130
28560384-10	2017	Furthermore, NaHS promoted the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, and the effects of NaHS on Drp1 expression were abolished by an ERK1/2 inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	181-188	dynamin 1-like	Mus musculus	126-130
28504877-6	2017	With the assistance of probe, we found that inhibition of Dynamin-related protein 1 (Drp1) could transduce a signal through mitochondrial complexes I and II to enhance the O2 - and pH levels and eventually induced mitohyperfusion and apoptosis in breast cancer cells.	Superoxides	172-174	dynamin 1-like	Mus musculus	58-83
28504877-6	2017	With the assistance of probe, we found that inhibition of Dynamin-related protein 1 (Drp1) could transduce a signal through mitochondrial complexes I and II to enhance the O2 - and pH levels and eventually induced mitohyperfusion and apoptosis in breast cancer cells.	Superoxides	172-174	dynamin 1-like	Mus musculus	85-89
28238799-2	2017	Here we show that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, is activated in primary OL cells exposed to TNF-alpha induced inflammation or oxidative stress, as well as in EAE-immunized and cuprizone toxicity-induced demyelinating mouse models.	Cuprizone	213-222	dynamin 1-like	Mus musculus	45-49
28238799-3	2017	Inhibition of Drp1 hyper-activation by the selective inhibitor P110 abolishes Drp1 translocation to the mitochondria, reduces mitochondrial fragmentation and stems necrosis in primary OLs exposed to TNF-alpha and H2O2.	Hydrogen Peroxide	213-217	dynamin 1-like	Mus musculus	14-18
28053612-7	2016	Moreover, glutamate treatment significantly decreased DLP-1 expression in a hippocampal-derived cell line.	Glutamic Acid	10-19	dynamin 1-like	Mus musculus	54-59
28190775-5	2017	Inducible deletion of DRP1 of mature POMC neurons (Drp1fl/fl-POMC-cre:ERT2) resulted in improved leptin sensitivity and glucose responsiveness.	Glucose	120-127	dynamin 1-like	Mus musculus	22-26
28085543-5	2017	Furthermore, autophagy inhibition by chloroquine treatment or ATG7 small interfering RNA (siRNA) transfection, upregulated DNM1L expression and triggered DNM1L-mediated mitochondrial fragmentation.	Chloroquine	37-48	dynamin 1-like	Mus musculus	123-128
28085543-5	2017	Furthermore, autophagy inhibition by chloroquine treatment or ATG7 small interfering RNA (siRNA) transfection, upregulated DNM1L expression and triggered DNM1L-mediated mitochondrial fragmentation.	Chloroquine	37-48	dynamin 1-like	Mus musculus	154-159
28085543-9	2017	Finally, the genetic (DNM1L siRNA) or pharmacological (mdivi-1) inhibition of DNMA1L ablated mitochondrial fragmentation in the mouse aortic endothelium and prevented the acetylcholine-induced relaxation of isolated mouse aortas.	Acetylcholine	171-184	dynamin 1-like	Mus musculus	22-27
28623750-0	2017	LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy.	sacubitril and valsartan sodium hydrate drug combination	0-6	dynamin 1-like	Mus musculus	49-53
28623750-7	2017	Fission protein Drp1 and its ser 616 phosphorylation were also increased post DOX and which could be reduced by LCZ696.	Serine	29-32	dynamin 1-like	Mus musculus	16-20
28623750-7	2017	Fission protein Drp1 and its ser 616 phosphorylation were also increased post DOX and which could be reduced by LCZ696.	Doxorubicin	78-81	dynamin 1-like	Mus musculus	16-20
28623750-7	2017	Fission protein Drp1 and its ser 616 phosphorylation were also increased post DOX and which could be reduced by LCZ696.	sacubitril and valsartan sodium hydrate drug combination	112-118	dynamin 1-like	Mus musculus	16-20
28623750-8	2017	In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1.	Serine	50-53	dynamin 1-like	Mus musculus	45-49
28623750-8	2017	In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1.	Serine	50-53	dynamin 1-like	Mus musculus	142-146
28623750-8	2017	In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1.	Doxorubicin	79-82	dynamin 1-like	Mus musculus	45-49
28623750-8	2017	In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1.	Doxorubicin	79-82	dynamin 1-like	Mus musculus	142-146
28623750-8	2017	In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1.	sacubitril and valsartan sodium hydrate drug combination	132-138	dynamin 1-like	Mus musculus	45-49
28623750-10	2017	CONCLUSION: The protective effect of LCZ696 against DOX-induced cardiac dysfunction is at least partly associated with alleviating Drp1-mediated mitochondrial dysfunction.	sacubitril and valsartan sodium hydrate drug combination	37-43	dynamin 1-like	Mus musculus	131-135
28623750-10	2017	CONCLUSION: The protective effect of LCZ696 against DOX-induced cardiac dysfunction is at least partly associated with alleviating Drp1-mediated mitochondrial dysfunction.	Doxorubicin	52-55	dynamin 1-like	Mus musculus	131-135
28432138-4	2017	Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in Abeta-treated neurons.	Oxygen	110-116	dynamin 1-like	Mus musculus	14-18
28432138-4	2017	Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in Abeta-treated neurons.	Adenosine Triphosphate	137-140	dynamin 1-like	Mus musculus	14-18
28190775-0	2017	DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.	Glucose	27-34	dynamin 1-like	Mus musculus	0-4
28230856-0	2017	Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1.	Ginsenosides	0-11	dynamin 1-like	Mus musculus	124-149
28230856-2	2017	This study was designed to investigate the cardioprotective effect of ginsenoside Rg5 (Rg5) with emphasis on the regulation of mitochondrial HK-II and Drp1.	ginsenoside Rg5	70-85	dynamin 1-like	Mus musculus	151-155
27861739-11	2017	Furthermore, while GalN/LPS significantly increased the level of fission-related protein, dynamin-related protein 1, and decreased the level of fusion-related protein, mitofusin 2; these effects were attenuated by afzelin.	Galactosamine	19-23	dynamin 1-like	Mus musculus	90-115
27861739-11	2017	Furthermore, while GalN/LPS significantly increased the level of fission-related protein, dynamin-related protein 1, and decreased the level of fusion-related protein, mitofusin 2; these effects were attenuated by afzelin.	afzelin	214-221	dynamin 1-like	Mus musculus	90-115
27737949-0	2017	Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission.	Metformin	0-9	dynamin 1-like	Mus musculus	80-84
27737949-5	2017	In high glucose-exposed endothelial cells, metformin treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial superoxide, lowered levels of dynamin-related protein (Drp1) and its translocation into mitochondria, and prevented mitochondrial fragmentation.	Metformin	43-52	dynamin 1-like	Mus musculus	206-210
27737949-6	2017	In contrast, AMPK-alpha2 deficiency abolished the effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis in diabetic ApoE-/-/AMPK-alpha2-/- mice, indicating that metformin exerts an antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.	Metformin	61-70	dynamin 1-like	Mus musculus	74-78
27737949-6	2017	In contrast, AMPK-alpha2 deficiency abolished the effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis in diabetic ApoE-/-/AMPK-alpha2-/- mice, indicating that metformin exerts an antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.	Metformin	61-70	dynamin 1-like	Mus musculus	275-279
27737949-8	2017	These findings show that metformin attenuated the development of atherosclerosis by reducing Drp1-mediated mitochondrial fission in an AMPK-dependent manner.	Metformin	25-34	dynamin 1-like	Mus musculus	93-97
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	Nitric Oxide	30-42	dynamin 1-like	Mus musculus	228-232
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	Nitric Oxide	30-42	dynamin 1-like	Mus musculus	254-258
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	1-Methyl-4-phenylpyridinium	68-99	dynamin 1-like	Mus musculus	228-232
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	1-Methyl-4-phenylpyridinium	68-99	dynamin 1-like	Mus musculus	254-258
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	mangion-purified polysaccharide (Candida albicans)	101-105	dynamin 1-like	Mus musculus	228-232
27267045-4	2016	RESULTS: We demonstrated that nitric oxide (NO) was overproduced on 1-methyl-4-phenylpyridinium ion (MPP+) treatment, which subsequently engendered S-nitrosylation of Parkin (SNO-Parkin), and thus decreased the interaction with Drp1, leading to elevated Drp1 expression.	mangion-purified polysaccharide (Candida albicans)	101-105	dynamin 1-like	Mus musculus	254-258
27267045-5	2016	Consistent with this, Drp1 was elevated in the ventral midbrain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated PD mouse models, a region usually affected by PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	67-111	dynamin 1-like	Mus musculus	22-26
27267045-5	2016	Consistent with this, Drp1 was elevated in the ventral midbrain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated PD mouse models, a region usually affected by PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	113-117	dynamin 1-like	Mus musculus	22-26
27267045-6	2016	Concomitantly, in a mouse model of MPTP-induced PD, both SNO-Parkin and Drp1 levels were increased, whereas no significant difference in SNO-Drp1 protein levels were found in these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	35-39	dynamin 1-like	Mus musculus	72-76
27267045-7	2016	In addition, NO stress, induced by MPP+, triggered the phosphorylation of Drp1 Ser616 and caused its subsequent recruitment to the mitochondria.	mangion-purified polysaccharide (Candida albicans)	35-39	dynamin 1-like	Mus musculus	74-78
26869350-3	2016	RESULTS: In endothelial cells, CRA induced dynamin-related protein 1 (Drp1) phosphorylation at Ser637 and thus inhibited mitochondrial fission in response to oxidative stress.	corosolic acid	31-34	dynamin 1-like	Mus musculus	43-68
26825530-6	2016	When isolated from diabetic mice and cultured in high glucose, Drp1-null podocytes had more elongated mitochondria and better mitochondrial fitness associated with enhanced oxygen consumption and ATP production than wild-type podocytes.	Glucose	54-61	dynamin 1-like	Mus musculus	63-67
26825530-6	2016	When isolated from diabetic mice and cultured in high glucose, Drp1-null podocytes had more elongated mitochondria and better mitochondrial fitness associated with enhanced oxygen consumption and ATP production than wild-type podocytes.	Oxygen	173-179	dynamin 1-like	Mus musculus	63-67
26825530-6	2016	When isolated from diabetic mice and cultured in high glucose, Drp1-null podocytes had more elongated mitochondria and better mitochondrial fitness associated with enhanced oxygen consumption and ATP production than wild-type podocytes.	Adenosine Triphosphate	196-199	dynamin 1-like	Mus musculus	63-67
26869350-6	2016	Drp1 knockdown reduced PA-induced gp91(phox) expression, while Drp1 induction was also diminished by gp91(phox) knockdown, suggesting the reciprocal relationship between NOX2 and Drp1.	Palmitates	23-25	dynamin 1-like	Mus musculus	0-4
26869350-7	2016	Knockdown Drp1 or gp91(phox) attenuated PA-induced NLRP3 induction and enhanced inhibitory effects of CRA.	Palmitates	40-42	dynamin 1-like	Mus musculus	10-14
26869350-3	2016	RESULTS: In endothelial cells, CRA induced dynamin-related protein 1 (Drp1) phosphorylation at Ser637 and thus inhibited mitochondrial fission in response to oxidative stress.	corosolic acid	31-34	dynamin 1-like	Mus musculus	70-74
33440569-0	2016	Drp1-Dependent Mitochondrial Fission Mediates Toxicity of Positively Charged Graphene in Microglia.	Graphite	77-85	dynamin 1-like	Mus musculus	0-4
27252826-9	2016	CONCLUSION: Exogenous H2S aids in inhibiting mitochondrial fragmentation and affects proliferation in db/db mice and HPASMCs by decreasing Drp 1 expression.	Hydrogen Sulfide	22-25	dynamin 1-like	Mus musculus	139-144
33440569-5	2016	Concurrent to mitochondrial fragmentation, treatment with positively charged GO-PEI induced an increase in mitochondrial recruitment of dynamin-related protein (Drp1).	go-pei	77-83	dynamin 1-like	Mus musculus	161-165
33440569-7	2016	However, Drp1 silencing by small interfering RNA (siRNA) could effectively attenuate GO-PEI-induced apoptotic and autophagic cell death, indicating that mitochondrial fragmentation occurs upstream of GO-PEI-mediated toxicity in microglia.	go-pei	85-91	dynamin 1-like	Mus musculus	9-13
33440569-8	2016	Overall, our study indicated that positively charged GO-PEI might cause deleterious influence on the central immune homeostasis by Drp1-dependent mitochondrial fragmentation, and provide the strategies for the rational design of graphene-based materials in neuroscience.	go-pei	53-59	dynamin 1-like	Mus musculus	131-135
33440569-8	2016	Overall, our study indicated that positively charged GO-PEI might cause deleterious influence on the central immune homeostasis by Drp1-dependent mitochondrial fragmentation, and provide the strategies for the rational design of graphene-based materials in neuroscience.	Graphite	229-237	dynamin 1-like	Mus musculus	131-135
26828481-6	2016	Further study showed that icariin treatment resulted in a decrease in mitochondrial fission protein dynamin-related protein 1 (Drp1) and an increase in fusion protein Mitofusin 2 (Mfn2).	icariin	26-33	dynamin 1-like	Mus musculus	100-125
26828481-6	2016	Further study showed that icariin treatment resulted in a decrease in mitochondrial fission protein dynamin-related protein 1 (Drp1) and an increase in fusion protein Mitofusin 2 (Mfn2).	icariin	26-33	dynamin 1-like	Mus musculus	127-131
27802433-7	2016	RESULTS: Inhibition of Drp1 and Dynamin 2 protected against mitochondrial fragmentation, maintained DeltaPsim, attenuated cellular ROS production and limited apoptosis.	Reactive Oxygen Species	131-134	dynamin 1-like	Mus musculus	23-27
26596858-9	2016	Our findings showed that up-regulation of Drp1 expression started at 1h post-TBI and peaked at 24 h, but inhibition of Drp1 by Mdivi-1 significantly alleviated TBI-induced behavioral deficits and brain edema, reduced morphological change of mitochondria, and decreased TBI-induced cell death together with lesion volume.	Hydrogen	69-71	dynamin 1-like	Mus musculus	42-46
27802433-1	2016	BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury.	Reactive Oxygen Species	75-98	dynamin 1-like	Mus musculus	31-36
27802433-1	2016	BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury.	Reactive Oxygen Species	100-103	dynamin 1-like	Mus musculus	31-36
27802433-10	2016	CONCLUSIONS: Oxidative stress-induced apoptosis and ROS production are attenuated by not only Drp1 inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.	Reactive Oxygen Species	52-55	dynamin 1-like	Mus musculus	94-98
26058514-4	2015	Using a cell-based functional screening system labeled with DsRed2-mito in BV-2 cells, we showed that LPS stimulation led to excessive mitochondrial fission, increased mitochondrial localization of dynamin-related protein 1 (Drp1), both of which were markedly suppressed by C60-COOH pretreatment.	Carbonic Acid	278-282	dynamin 1-like	Mus musculus	198-223
27597885-0	2016	Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation.	Oxygen	24-30	dynamin 1-like	Mus musculus	83-87
27597885-0	2016	Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation.	Glucose	31-38	dynamin 1-like	Mus musculus	83-87
26058514-4	2015	Using a cell-based functional screening system labeled with DsRed2-mito in BV-2 cells, we showed that LPS stimulation led to excessive mitochondrial fission, increased mitochondrial localization of dynamin-related protein 1 (Drp1), both of which were markedly suppressed by C60-COOH pretreatment.	Carbonic Acid	278-282	dynamin 1-like	Mus musculus	225-229
26381214-4	2015	RIPK3-mediated activation of PGAM5 promotes the expression of cytokines by facilitating nuclear translocation of NFAT and dephosphorylation of dynamin-related protein 1 (Drp1), a GTPase is essential for mitochondrial homoeostasis.	pgam5	29-34	dynamin 1-like	Mus musculus	143-168
26370078-9	2015	In conclusion, failure of Drp1 disassembly impairs mitophagy, leading to a downstream cascade of mitochondrial depolarization, aberrant calcium handling, impaired ATP synthesis, and activation of sterile myocardial inflammation, resulting in heart failure.	Calcium	136-143	dynamin 1-like	Mus musculus	26-30
26370078-9	2015	In conclusion, failure of Drp1 disassembly impairs mitophagy, leading to a downstream cascade of mitochondrial depolarization, aberrant calcium handling, impaired ATP synthesis, and activation of sterile myocardial inflammation, resulting in heart failure.	Adenosine Triphosphate	163-166	dynamin 1-like	Mus musculus	26-30
26381214-4	2015	RIPK3-mediated activation of PGAM5 promotes the expression of cytokines by facilitating nuclear translocation of NFAT and dephosphorylation of dynamin-related protein 1 (Drp1), a GTPase is essential for mitochondrial homoeostasis.	pgam5	29-34	dynamin 1-like	Mus musculus	170-174
25192600-3	2015	We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation.	Serine	84-87	dynamin 1-like	Mus musculus	60-64
25602369-4	2015	Utilizing a novel biotin-avidin capture technique, we found that the oxidation status of Parkin and the mitochondrial fission protein, dynamin-related protein 1 (Drp1), are altered in a CHIP-dependent manner.	Biotin	18-24	dynamin 1-like	Mus musculus	135-160
25602369-4	2015	Utilizing a novel biotin-avidin capture technique, we found that the oxidation status of Parkin and the mitochondrial fission protein, dynamin-related protein 1 (Drp1), are altered in a CHIP-dependent manner.	Biotin	18-24	dynamin 1-like	Mus musculus	162-166
26247724-5	2015	DRP1 inhibition promotes RGC survival by increasing phosphorylation of Bad at serine 112 in the retina and preserves RGC axons by maintaining mt integrity in the glial lamina of glaucomatous D2 mice.	Serine	78-84	dynamin 1-like	Mus musculus	0-4
25587046-10	2015	In an in vivo model of intimal hyperplasia, transgenic mice expressing DLP1-K38A displayed markedly reduced ROS levels and neointima formation in response to femoral artery wire injury.	ros	108-111	dynamin 1-like	Mus musculus	71-75
25766316-6	2015	DOX-induced mitochondrial fission required the activity of dynamin-related protein 1 (Drp1).	Doxorubicin	0-3	dynamin 1-like	Mus musculus	59-84
25766316-6	2015	DOX-induced mitochondrial fission required the activity of dynamin-related protein 1 (Drp1).	Doxorubicin	0-3	dynamin 1-like	Mus musculus	86-90
25880092-8	2015	Although Drp1KO increased the distance between axonal mitochondria, mitochondrial-derived ATP still decreased similarly in Drp1KO boutons with and without mitochondria.	Adenosine Triphosphate	90-93	dynamin 1-like	Mus musculus	123-129
25880092-9	2015	This indicates that mitochondrial-derived ATP is rapidly dispersed in Drp1KO axons, and that the deficits in axonal bioenergetics and function are not caused by regional energy gradients.	Adenosine Triphosphate	42-45	dynamin 1-like	Mus musculus	70-76
25599491-2	2015	Dynamin-related protein 1, a regulator of mitochondrial fission, is an important determinant of reactive oxygen species generation, myocardial necrosis, and left ventricular function following ischemia/reperfusion injury, but its role in cardiac arrest is unknown.	Reactive Oxygen Species	96-119	dynamin 1-like	Mus musculus	0-25
25332205-7	2015	Mitochondrial elongation and accumulation of damaged mitochondria were also observed in tamoxifen-inducible cardiac-specific Drp1 knockout mice.	Tamoxifen	88-97	dynamin 1-like	Mus musculus	125-129
25841124-6	2015	In this study, we hypothesize that disrupted fission and fusion balance by increased Drp-1 and decreased Mfn2 expression in cardiomyocytes affects their contractility through alterations in the calcium and potassium concentrations.	Calcium	194-201	dynamin 1-like	Mus musculus	85-90
25192600-3	2015	We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation.	Serine	84-87	dynamin 1-like	Mus musculus	121-125
25192600-3	2015	We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation.	Serine	96-99	dynamin 1-like	Mus musculus	60-64
25192600-3	2015	We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation.	Serine	96-99	dynamin 1-like	Mus musculus	121-125
25047000-9	2014	Interestingly, the Tau/GSK3beta double tg mice also displayed elevated levels of Dynamin-related protein-1 (Drp-1), a protein that hydrolyzes GTP and is required for mitochondrial division.	Guanosine Triphosphate	142-145	dynamin 1-like	Mus musculus	81-106
25370169-0	2014	Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.	Dopamine	45-53	dynamin 1-like	Mus musculus	0-4
25370169-6	2014	Specifically, we show that inhibition of the mitochondrial fission GTPase dynamin-related protein-1 (Drp1) using gene-based and small-molecule approaches attenuates neurotoxicity and restores pre-existing striatal dopamine release deficits in these animal models.	Dopamine	214-222	dynamin 1-like	Mus musculus	101-105
25047000-9	2014	Interestingly, the Tau/GSK3beta double tg mice also displayed elevated levels of Dynamin-related protein-1 (Drp-1), a protein that hydrolyzes GTP and is required for mitochondrial division.	Guanosine Triphosphate	142-145	dynamin 1-like	Mus musculus	108-113
25047000-11	2014	CBL treatment normalized levels of Drp-1 and restored mitochondrial structure.	cerebrolysin	0-3	dynamin 1-like	Mus musculus	35-40
24284040-0	2014	Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.	Glutamic Acid	55-64	dynamin 1-like	Mus musculus	18-43
24556414-8	2014	Specifically, nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1).	Nitrites	14-21	dynamin 1-like	Mus musculus	212-237
24556414-8	2014	Specifically, nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1).	Nitrites	14-21	dynamin 1-like	Mus musculus	239-243
24556414-10	2014	Importantly, inhibition of PKA or Drp1 significantly attenuates nitrite-induced mitochondrial respiration and glucose uptake.	Nitrites	64-71	dynamin 1-like	Mus musculus	34-38
24556414-10	2014	Importantly, inhibition of PKA or Drp1 significantly attenuates nitrite-induced mitochondrial respiration and glucose uptake.	Glucose	110-117	dynamin 1-like	Mus musculus	34-38
24284040-0	2014	Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.	Calcium	131-138	dynamin 1-like	Mus musculus	18-43
24284040-3	2014	Here we investigated the effect of downregulating Drp-1 on glutamate excitotoxicity-induced neuronal injury in HT22 cells.	Glutamic Acid	59-68	dynamin 1-like	Mus musculus	50-55
24284040-4	2014	We found that downregulation of Drp-1 with specific small interfering RNA (siRNA) increased cell viability and inhibited lactate dehydrogenase (LDH) release after glutamate treatment.	Glutamic Acid	163-172	dynamin 1-like	Mus musculus	32-37
24284040-6	2014	Drp-1 siRNA transfection preserved the mitochondrial membrane potential (MMP), reduced cytochrome c release, enhanced ATP production, and partly prevented mitochondrial swelling.	Adenosine Triphosphate	118-121	dynamin 1-like	Mus musculus	0-5
24284040-7	2014	In addition, Drp-1 knockdown attenuated glutamate-induced increases of cytoplasmic and mitochondrial Ca(2+), and preserved the mitochondrial Ca(2+) buffering capacity after excitotoxicity.	Glutamic Acid	40-49	dynamin 1-like	Mus musculus	13-18
24284040-8	2014	Taken together, these results suggest that downregulation of Drp-1 protects HT22 cells against glutamate-induced excitatory damage, and this neuroprotection may be dependent at least in part on the preservation of mitochondrial function through regulating intracellular calcium homeostasis.	Glutamic Acid	95-104	dynamin 1-like	Mus musculus	61-66
24284040-8	2014	Taken together, these results suggest that downregulation of Drp-1 protects HT22 cells against glutamate-induced excitatory damage, and this neuroprotection may be dependent at least in part on the preservation of mitochondrial function through regulating intracellular calcium homeostasis.	Calcium	270-277	dynamin 1-like	Mus musculus	61-66
24363996-12	2013	In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1).	Linoleic Acids, Conjugated	28-31	dynamin 1-like	Mus musculus	95-120
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	15-19	dynamin 1-like	Mus musculus	59-84
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	15-19	dynamin 1-like	Mus musculus	86-90
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	15-19	dynamin 1-like	Mus musculus	190-194
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	219-223	dynamin 1-like	Mus musculus	59-84
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	219-223	dynamin 1-like	Mus musculus	86-90
23744808-8	2013	Interestingly, APAP-induced mitochondrial translocation of dynamin-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 protein expression and the Drp1 inhibitor MDIVI reduced APAP-induced cell death at 24 hours.	Acetaminophen	219-223	dynamin 1-like	Mus musculus	190-194
24363996-12	2013	In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1).	Nitrites	36-43	dynamin 1-like	Mus musculus	95-120
24363996-12	2013	In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1).	Nitrites	36-43	dynamin 1-like	Mus musculus	122-127
24363996-12	2013	In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1).	Linoleic Acids, Conjugated	28-31	dynamin 1-like	Mus musculus	122-127
23919963-8	2013	Finally, mechanistic study further suggested that decreased Drp1 level by rhein might be due to its effect on reducing cellular reactive oxygen species.	Reactive Oxygen Species	128-151	dynamin 1-like	Mus musculus	60-64
23904108-4	2013	We found that differentiation of C2C12 myoblasts induced by serum starvation was accompanied by a gradual increase in Drp1 protein expression (to ~350% up to 3 days) and a fast reduction of Drp1 phosphorylation at Ser-637 (to ~30%) resulting in translocation of Drp1 protein from the cytosol to mitochondria.	Serine	214-217	dynamin 1-like	Mus musculus	190-194
23904108-4	2013	We found that differentiation of C2C12 myoblasts induced by serum starvation was accompanied by a gradual increase in Drp1 protein expression (to ~350% up to 3 days) and a fast reduction of Drp1 phosphorylation at Ser-637 (to ~30%) resulting in translocation of Drp1 protein from the cytosol to mitochondria.	Serine	214-217	dynamin 1-like	Mus musculus	190-194
22326220-6	2012	Importantly, we found that ROCK1 triggers mitochondrial fission by phosphorylating Drp1 at serine 600 residue.	Serine	91-97	dynamin 1-like	Mus musculus	83-87
23815397-7	2013	Interestingly, inhibition of LPS-induced mitochondrial fission and reactive oxygen species (ROS) generation by Mdivi-1 and Drp1 knock-down attenuated the production of pro-inflammatory mediators via reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling.	Reactive Oxygen Species	67-90	dynamin 1-like	Mus musculus	123-127
23815397-7	2013	Interestingly, inhibition of LPS-induced mitochondrial fission and reactive oxygen species (ROS) generation by Mdivi-1 and Drp1 knock-down attenuated the production of pro-inflammatory mediators via reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling.	Reactive Oxygen Species	92-95	dynamin 1-like	Mus musculus	123-127
22703557-4	2013	RESULTS: Here, we report that the effects of dexamethasone on mitochondrial function and gluconeogenesis in hepatoma cells are dependent on the mitochondrial fission protein dynamin-related protein 1 (Drp1).	Dexamethasone	45-58	dynamin 1-like	Mus musculus	174-199
22703557-4	2013	RESULTS: Here, we report that the effects of dexamethasone on mitochondrial function and gluconeogenesis in hepatoma cells are dependent on the mitochondrial fission protein dynamin-related protein 1 (Drp1).	Dexamethasone	45-58	dynamin 1-like	Mus musculus	201-205
22703557-6	2013	Under these conditions, dexamethasone altered mitochondrial morphology, which was paralleled by a large increase in Drp1 expression, and reduced mitofusin 1 (Mfn1) and Mfn2.	Dexamethasone	24-37	dynamin 1-like	Mus musculus	116-120
22703557-7	2013	In vivo dexamethasone treatment also enhanced Drp1 expression in mouse liver.	Dexamethasone	8-21	dynamin 1-like	Mus musculus	46-50
22703557-8	2013	On the basis of these observations, we analyzed the dependence on the Drp1 function of dexamethasone effects on mitochondrial respiration and gluconeogenesis.	Dexamethasone	87-100	dynamin 1-like	Mus musculus	70-74
22703557-9	2013	We show that the increase in mitochondrial respiration and gluconeogenesis induced by dexamethasone are hampered by the inhibition of Drp1 function.	Dexamethasone	86-99	dynamin 1-like	Mus musculus	134-138
22703557-11	2013	CONCLUSION: In summary, we demonstrate that the mitochondrial effects of dexamethasone both on mitochondrial respiration and on the gluconeogenic pathway depend on Drp1.	Dexamethasone	73-86	dynamin 1-like	Mus musculus	164-168
22388349-3	2012	Here, we investigated the role of dynamin-related protein 1 (Drp1), one of the key regulators of mitochondrial fission, in neuronal cell death induced by glutamate toxicity or oxygen-glucose deprivation (OGD) in vitro, and after ischemic brain damage in vivo.	Glutamic Acid	154-163	dynamin 1-like	Mus musculus	34-59
22388349-3	2012	Here, we investigated the role of dynamin-related protein 1 (Drp1), one of the key regulators of mitochondrial fission, in neuronal cell death induced by glutamate toxicity or oxygen-glucose deprivation (OGD) in vitro, and after ischemic brain damage in vivo.	Glutamic Acid	154-163	dynamin 1-like	Mus musculus	61-65
22388349-4	2012	Drp1 siRNA and small molecule inhibitors of Drp1 prevented mitochondrial fission, loss of mitochondrial membrane potential (MMP), and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells.	Glutamic Acid	156-165	dynamin 1-like	Mus musculus	0-4
22388349-4	2012	Drp1 siRNA and small molecule inhibitors of Drp1 prevented mitochondrial fission, loss of mitochondrial membrane potential (MMP), and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells.	Glutamic Acid	156-165	dynamin 1-like	Mus musculus	44-48
22388349-4	2012	Drp1 siRNA and small molecule inhibitors of Drp1 prevented mitochondrial fission, loss of mitochondrial membrane potential (MMP), and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells.	tBID	169-173	dynamin 1-like	Mus musculus	0-4
22388349-4	2012	Drp1 siRNA and small molecule inhibitors of Drp1 prevented mitochondrial fission, loss of mitochondrial membrane potential (MMP), and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells.	tBID	169-173	dynamin 1-like	Mus musculus	44-48
22388349-5	2012	Further, Drp1 inhibitors protected primary neurons against glutamate excitotoxicity and OGD, and reduced the infarct volume in a mouse model of transient focal ischemia.	Glutamic Acid	59-68	dynamin 1-like	Mus musculus	9-13
22388349-7	2012	Thus, inhibition of Drp1 is proposed as an efficient strategy of neuroprotection against glutamate toxicity and OGD in vitro and ischemic brain damage in vivo.	Glutamic Acid	89-98	dynamin 1-like	Mus musculus	20-24
22387883-8	2012	However, H(2)O(2) and lipid peroxidation levels were significantly reduced in the Drp1 heterozygote knockout mice compared to the wild-type mice.	Hydrogen Peroxide	9-17	dynamin 1-like	Mus musculus	82-86
22345048-3	2012	This study showed that mitochondrial fission protein dynamin-related protein 1 (Drp1) and fusion protein optic atrophy 1 (Opa1) were both upregulated in the ischemic penumbra, with the peak at 2 days after tMCAO, whereas phosphorylated-Drp1 (P-Drp1) progressively increased with a peak at 14 days after tMCAO.	tmcao	206-211	dynamin 1-like	Mus musculus	53-78
22345048-3	2012	This study showed that mitochondrial fission protein dynamin-related protein 1 (Drp1) and fusion protein optic atrophy 1 (Opa1) were both upregulated in the ischemic penumbra, with the peak at 2 days after tMCAO, whereas phosphorylated-Drp1 (P-Drp1) progressively increased with a peak at 14 days after tMCAO.	tmcao	206-211	dynamin 1-like	Mus musculus	80-84
22345048-3	2012	This study showed that mitochondrial fission protein dynamin-related protein 1 (Drp1) and fusion protein optic atrophy 1 (Opa1) were both upregulated in the ischemic penumbra, with the peak at 2 days after tMCAO, whereas phosphorylated-Drp1 (P-Drp1) progressively increased with a peak at 14 days after tMCAO.	tmcao	303-308	dynamin 1-like	Mus musculus	53-78
22345048-3	2012	This study showed that mitochondrial fission protein dynamin-related protein 1 (Drp1) and fusion protein optic atrophy 1 (Opa1) were both upregulated in the ischemic penumbra, with the peak at 2 days after tMCAO, whereas phosphorylated-Drp1 (P-Drp1) progressively increased with a peak at 14 days after tMCAO.	tmcao	303-308	dynamin 1-like	Mus musculus	80-84
22345048-5	2012	In contrast, both Drp1 and Opa1 showed progressive decreases until 2 days after tMCAO in the ischemic core because of necrotic brain damage.	tmcao	80-85	dynamin 1-like	Mus musculus	18-22
22498177-3	2012	The present study showed that mitochondrial fission protein fission 1 (Fis1) and phosphorylated dynamin-related protein 1 (P-Drp1) both progressively increased with the peak at 14 d after tMCAO.	tmcao	188-193	dynamin 1-like	Mus musculus	96-121
22498177-4	2012	Double immunofluorescent analysis showed the number of double positive cells with Fis1/Drp1 reduced between 2 and 28 d after 90 min of tMCAO, and also showed some double positive cells with Fis1/terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) in the peri-infract regions at 2d after the reperfusion.	tmcao	135-140	dynamin 1-like	Mus musculus	87-91
22498177-4	2012	Double immunofluorescent analysis showed the number of double positive cells with Fis1/Drp1 reduced between 2 and 28 d after 90 min of tMCAO, and also showed some double positive cells with Fis1/terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) in the peri-infract regions at 2d after the reperfusion.	deoxyuridine triphosphate	242-246	dynamin 1-like	Mus musculus	87-91
22498177-4	2012	Double immunofluorescent analysis showed the number of double positive cells with Fis1/Drp1 reduced between 2 and 28 d after 90 min of tMCAO, and also showed some double positive cells with Fis1/terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) in the peri-infract regions at 2d after the reperfusion.	Digoxigenin	247-258	dynamin 1-like	Mus musculus	87-91
21724752-6	2011	However, when treated with CGP37157 (CGP), an inhibitor of mitochondrial Ca2+ efflux, these cells exhibited mitochondrial fission, which was further enhanced by pretreatment with R1881, suggesting that androgen-induced Drp1 expression facilitated CGP-induced mitochondrial fission.	7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one	27-35	dynamin 1-like	Mus musculus	219-223
21537829-5	2011	We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions.	Reactive Oxygen Species	147-170	dynamin 1-like	Mus musculus	207-212
21537829-5	2011	We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions.	Reactive Oxygen Species	147-170	dynamin 1-like	Mus musculus	234-239
21537829-5	2011	We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions.	Reactive Oxygen Species	172-175	dynamin 1-like	Mus musculus	207-212
21537829-5	2011	We further demonstrated that the mitochondrial membrane potential decreased, and that cytochrome c release, caspase-3 activation and generation of reactive oxygen species (ROS) were enhanced by induction of DRP-1 WT, but prevented by DRP-1 K38A in pancreatic beta-cells under ER stress conditions.	Reactive Oxygen Species	172-175	dynamin 1-like	Mus musculus	234-239
22158479-1	2011	Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases, mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial outer membrane fission protein.	Glutamic Acid	0-9	dynamin 1-like	Mus musculus	137-162
21605084-11	2011	In the acute model, doxorubicin exposure was associated with increased mtDNA content, mitochondrial fragmentation and changes in mitochondrial fusion- and fission-related transcripts [increases in Mfn2 (mitofusin 2), Opa1 (optic atrophy 1 homologue) and Fis1 (fission 1 homologue), and no changes in Drp1 (dynamin 1-like)].	Doxorubicin	20-31	dynamin 1-like	Mus musculus	300-304
21724752-4	2011	Treatment of androgen-sensitive cells with an AR agonist, R1881, and antagonist, bicalutamide, showed that Drp1 is transcriptionally regulated by androgens, as confirmed by an AR ChIP-seq assay.	bicalutamide	81-93	dynamin 1-like	Mus musculus	107-111
20666976-13	2010	Western blot analysis confirmed that melatonin prevents the hepatic I-R injury-induced decrease in DLP-1.	Melatonin	37-46	dynamin 1-like	Mus musculus	99-104
19752021-4	2009	This embryonic lethality is not likely caused by gross energy deprivation, as Drp1-null cells showed normal intracellular adenosine triphosphate levels.	Adenosine Triphosphate	122-144	dynamin 1-like	Mus musculus	78-82