PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23486469-3	2013	Phosphorylation of Ser-656 by cAMP-dependent protein kinase (PKA) inhibits Drp1, whereas dephosphorylation by a mitochondrial protein phosphatase 2A isoform and the calcium-calmodulin-dependent phosphatase calcineurin (CaN) activates Drp1.	Serine	19-22	dynamin 1 like	Homo sapiens	75-79
23486469-3	2013	Phosphorylation of Ser-656 by cAMP-dependent protein kinase (PKA) inhibits Drp1, whereas dephosphorylation by a mitochondrial protein phosphatase 2A isoform and the calcium-calmodulin-dependent phosphatase calcineurin (CaN) activates Drp1.	Serine	19-22	dynamin 1 like	Homo sapiens	234-238
23486469-7	2013	With tools for bidirectional control of the CaN-Drp1 signaling axis in hand, we demonstrate that the Drp1 LXVP motif shapes mitochondria in neuronal and non-neuronal cells, and that CaN-mediated Drp1 dephosphorylation promotes neuronal death following oxygen-glucose deprivation.	oxygen-glucose	252-266	dynamin 1 like	Homo sapiens	101-105
23486469-7	2013	With tools for bidirectional control of the CaN-Drp1 signaling axis in hand, we demonstrate that the Drp1 LXVP motif shapes mitochondria in neuronal and non-neuronal cells, and that CaN-mediated Drp1 dephosphorylation promotes neuronal death following oxygen-glucose deprivation.	oxygen-glucose	252-266	dynamin 1 like	Homo sapiens	101-105
22005465-0	2011	Ionizing radiation accelerates Drp1-dependent mitochondrial fission, which involves delayed mitochondrial reactive oxygen species production in normal human fibroblast-like cells.	Reactive Oxygen Species	106-129	dynamin 1 like	Homo sapiens	31-35
23492771-0	2013	Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity.	Cadmium	0-7	dynamin 1 like	Homo sapiens	16-20
23492771-0	2013	Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity.	Calcium	73-80	dynamin 1 like	Homo sapiens	16-20
23492771-5	2013	Concurrent to mitochondrial fragmentation, CdCl2 treatment increased the protein levels of dynamin-related protein (Drp1) and promoted the recruitment of Drp1 into mitochondria.	Cadmium Chloride	43-48	dynamin 1 like	Homo sapiens	116-120
23492771-5	2013	Concurrent to mitochondrial fragmentation, CdCl2 treatment increased the protein levels of dynamin-related protein (Drp1) and promoted the recruitment of Drp1 into mitochondria.	Cadmium Chloride	43-48	dynamin 1 like	Homo sapiens	154-158
23492771-7	2013	Moreover, in L02 cells, Drp1 silencing could effectively reverse Cd-induced mitochondrial fragmentation and mitochondrial dysfunction.	Cadmium	65-67	dynamin 1 like	Homo sapiens	24-28
23492771-8	2013	Furthermore, the increased expression and mitochondrial recruitment of Drp1 were tightly related to the disturbance of calcium homeostasis, which could be prevented by both chelating [Ca2+]i and inhibiting [Ca2+]m uptake.	Calcium	119-126	dynamin 1 like	Homo sapiens	71-75
23492771-9	2013	Overall, our study indicated that Cd induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis to promote hepatotoxicity.	Cadmium	34-36	dynamin 1 like	Homo sapiens	45-49
23492771-9	2013	Overall, our study indicated that Cd induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis to promote hepatotoxicity.	Calcium	102-109	dynamin 1 like	Homo sapiens	45-49
23492771-10	2013	Manipulation of Drp1 may be the potential avenue for developing novel strategies to protect against cadmium-induced hepatotoxicity.	Cadmium	100-107	dynamin 1 like	Homo sapiens	16-20
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Oxygen	92-94	dynamin 1 like	Homo sapiens	19-23
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Phenylephrine	150-163	dynamin 1 like	Homo sapiens	19-23
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Potassium Chloride	167-170	dynamin 1 like	Homo sapiens	19-23
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Oxygen	187-189	dynamin 1 like	Homo sapiens	19-23
23334860-13	2013	The small molecule Drp1 inhibitor, Mdivi-1, and siDRP1 yield concordant results, inhibiting O2-induced constriction (without altering the response to phenylephrine or KCl) and preventing O2-induced increases in oxidative metabolism, cytosolic calcium, and ductal smooth muscle cells proliferation.	Calcium	243-250	dynamin 1 like	Homo sapiens	19-23
22846607-8	2013	Addition of 6-OHDA did not increase the levels of fission 1, mitofusins 1 and 2 or optic atrophy 1 proteins, but does lead to the translocation of dynamin related protein 1 from the cytosol to the mitochondria.	Oxidopamine	12-18	dynamin 1 like	Homo sapiens	147-172
22846607-9	2013	Pre-treatment with MitoQ (50nM, 30min) results in the inhibition of the mitochondrial translocation of Drp1.	mitoquinone	19-24	dynamin 1 like	Homo sapiens	103-107
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	152-166	dynamin 1 like	Homo sapiens	111-115
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	152-166	dynamin 1 like	Homo sapiens	117-142
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	152-166	dynamin 1 like	Homo sapiens	173-177
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	168-171	dynamin 1 like	Homo sapiens	111-115
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	168-171	dynamin 1 like	Homo sapiens	117-142
24587691-5	2013	In this review, we focus on the signaling pathway whereby S-nitrosylation of the mitochondrial fission protein Drp1 (dynamin-related protein 1; forming S-nitrosothiol (SNO)-Drp1) precipitates excessive mitochondrial fission or fragmentation and consequent bioenergetic compromise.	S-Nitrosothiols	168-171	dynamin 1 like	Homo sapiens	173-177
23027751-3	2012	Drp1 shares structural and functional similarities with dynamin 1 with respect to domain organization, ability to self-assemble into spiral-like oligomers and GTP-cycle-dependent membrane scission.	Guanosine Triphosphate	159-162	dynamin 1 like	Homo sapiens	0-4
22511751-3	2012	Dynamin-related protein-1 (DRP1) is a GTPase that, when activated by kinases that phosphorylate serine 616, causes mitochondrial fission.	Serine	96-102	dynamin 1 like	Homo sapiens	0-25
22511751-3	2012	Dynamin-related protein-1 (DRP1) is a GTPase that, when activated by kinases that phosphorylate serine 616, causes mitochondrial fission.	Serine	96-102	dynamin 1 like	Homo sapiens	27-31
22511751-5	2012	OBJECTIVE: We hypothesize that DRP1 activation is responsible for increased mitochondrial fission in PAH PASMCs and that DRP1 inhibition may slow proliferation and have therapeutic potential.	pasmcs	105-111	dynamin 1 like	Homo sapiens	31-35
22511751-8	2012	HIF-1alpha activation in human PAH leads to mitochondrial fission by cyclin B1/CDK1-dependent phosphorylation of DRP1 at serine 616.	Serine	121-127	dynamin 1 like	Homo sapiens	113-117
22511751-9	2012	In normal PASMCs, HIF-1alpha activation by CoCl(2) or desferrioxamine causes DRP1-mediated fission.	cobaltous chloride	43-50	dynamin 1 like	Homo sapiens	77-81
22511751-9	2012	In normal PASMCs, HIF-1alpha activation by CoCl(2) or desferrioxamine causes DRP1-mediated fission.	Deferoxamine	54-69	dynamin 1 like	Homo sapiens	77-81
22511751-11	2012	Both the DRP1 inhibitor Mdivi-1 and siDRP1 prevent mitotic fission and arrest PAH PASMCs at the G2/M interphase.	pasmcs	82-88	dynamin 1 like	Homo sapiens	9-13
22334657-1	2012	The mechanoenzyme dynamin-related protein 1 (Drp1) hydrolyzes GTP to power mitochondrial fission, a process required for organelle biogenesis, quality control, transport, and apoptosis.	Guanosine Triphosphate	62-65	dynamin 1 like	Homo sapiens	18-43
22334657-1	2012	The mechanoenzyme dynamin-related protein 1 (Drp1) hydrolyzes GTP to power mitochondrial fission, a process required for organelle biogenesis, quality control, transport, and apoptosis.	Guanosine Triphosphate	62-65	dynamin 1 like	Homo sapiens	45-49
22334657-5	2012	Consistent with an autoinhibitory role of the VD, we identified Arg-376 in the Drp1 stalk domain as necessary for Mff interaction, assembly into spirals, and mitochondrial fission.	Arginine	64-67	dynamin 1 like	Homo sapiens	79-83
22334657-10	2012	This in turn modulates Arg-376-dependent OMM targeting of Drp1 via multivalent interactions with Mff.	Arginine	23-26	dynamin 1 like	Homo sapiens	58-62
21615675-0	2011	DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson"s disease.	1-Methyl-4-phenylpyridinium	52-79	dynamin 1 like	Homo sapiens	0-4
23334860-0	2013	Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.	Oxygen	75-81	dynamin 1 like	Homo sapiens	8-33
23334860-0	2013	Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.	Oxygen	75-81	dynamin 1 like	Homo sapiens	35-39
23334860-9	2013	O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Oxygen	0-2	dynamin 1 like	Homo sapiens	114-139
23334860-9	2013	O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Oxygen	0-2	dynamin 1 like	Homo sapiens	141-145
23334860-9	2013	O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Serine	150-156	dynamin 1 like	Homo sapiens	114-139
23334860-9	2013	O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Serine	150-156	dynamin 1 like	Homo sapiens	141-145
22773688-5	2012	Moreover, mitochondrial fission molecules, e.g., protein dynamin-related protein 1, as well as Htt, associated with mitochondrial raft-like microdomains, glycosphingolipid-enriched structures detectable in mitochondria.	Glycosphingolipids	154-171	dynamin 1 like	Homo sapiens	57-82
22821850-4	2012	Upon 6-OHDA treatment, dynamin-related protein 1 (Drp1) transiently translocated to mitochondria, with increased levels of mitochondrial Drp1 being observed after 3 and 9h.	Oxidopamine	5-11	dynamin 1 like	Homo sapiens	23-48
22821850-4	2012	Upon 6-OHDA treatment, dynamin-related protein 1 (Drp1) transiently translocated to mitochondria, with increased levels of mitochondrial Drp1 being observed after 3 and 9h.	Oxidopamine	5-11	dynamin 1 like	Homo sapiens	50-54
22821850-4	2012	Upon 6-OHDA treatment, dynamin-related protein 1 (Drp1) transiently translocated to mitochondria, with increased levels of mitochondrial Drp1 being observed after 3 and 9h.	Oxidopamine	5-11	dynamin 1 like	Homo sapiens	137-141
22745122-0	2012	Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes.	o-linked-beta-n-acetylglucosamine	69-102	dynamin 1 like	Homo sapiens	14-39
22745122-0	2012	Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes.	o-linked-beta-n-acetylglucosamine	69-102	dynamin 1 like	Homo sapiens	41-45
22745122-5	2012	In this study, we found that dynamin-related protein 1 (DRP1) is O-GlcNAcylated in cardiomyocytes at threonine 585 and 586.	Threonine	101-110	dynamin 1 like	Homo sapiens	29-54
22745122-5	2012	In this study, we found that dynamin-related protein 1 (DRP1) is O-GlcNAcylated in cardiomyocytes at threonine 585 and 586.	Threonine	101-110	dynamin 1 like	Homo sapiens	56-60
22745122-7	2012	Increased O-GlcNAcylation decreases the phosphorylation of DRP1 at serine 637, which is known to regulate DRP1 function.	Serine	67-73	dynamin 1 like	Homo sapiens	59-63
22745122-7	2012	Increased O-GlcNAcylation decreases the phosphorylation of DRP1 at serine 637, which is known to regulate DRP1 function.	Serine	67-73	dynamin 1 like	Homo sapiens	106-110
22745122-8	2012	In fact, increased O-GlcNAcylation augments the level of the GTP-bound active form of DRP1 and induces translocation of DRP1 from the cytoplasm to mitochondria.	Guanosine Triphosphate	61-64	dynamin 1 like	Homo sapiens	86-90
23284813-9	2012	The reduction in Drp1 and Mff protein levels was rescued following treatment with the proteasome inhibitor MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	107-112	dynamin 1 like	Homo sapiens	17-21
21747057-7	2011	Silencing Fis1 or Drp1 expression with siRNA blunted high glucose-induced alterations in mitochondrial networks, reactive oxygen species production, endothelial nitric oxide synthase activation, and cGMP production.	Cyclic GMP	199-203	dynamin 1 like	Homo sapiens	18-22
21747057-5	2011	In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission.	Glucose	64-71	dynamin 1 like	Homo sapiens	163-188
21747057-5	2011	In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission.	Glucose	64-71	dynamin 1 like	Homo sapiens	190-194
21747057-7	2011	Silencing Fis1 or Drp1 expression with siRNA blunted high glucose-induced alterations in mitochondrial networks, reactive oxygen species production, endothelial nitric oxide synthase activation, and cGMP production.	Glucose	58-65	dynamin 1 like	Homo sapiens	18-22
21747057-7	2011	Silencing Fis1 or Drp1 expression with siRNA blunted high glucose-induced alterations in mitochondrial networks, reactive oxygen species production, endothelial nitric oxide synthase activation, and cGMP production.	Reactive Oxygen Species	113-136	dynamin 1 like	Homo sapiens	18-22
21145355-2	2011	The GTPase family of proteins, including fission proteins, dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1), and fusion proteins (Mfn1, Mfn2 and Opa1) are essential to maintain mitochondrial fission and fusion balance, and to provide necessary adenosine triphosphate to neurons.	Adenosine	260-269	dynamin 1 like	Homo sapiens	59-84
21145355-2	2011	The GTPase family of proteins, including fission proteins, dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1), and fusion proteins (Mfn1, Mfn2 and Opa1) are essential to maintain mitochondrial fission and fusion balance, and to provide necessary adenosine triphosphate to neurons.	Adenosine	260-269	dynamin 1 like	Homo sapiens	86-90
21453958-12	2011	The calcium-dependent calcineurin and Drp1 are activated 30 minutes after SP stimulation.	Calcium	4-11	dynamin 1 like	Homo sapiens	38-42
21326213-4	2011	Moreover, Drp1 knockdown enhanced mitochondrial depolarization and T-cell receptor signal strength, but decreased myosin phosphorylation, ATP production and T-cell receptor assembly at the central supramolecular activation cluster (cSMAC).	Adenosine Triphosphate	138-141	dynamin 1 like	Homo sapiens	10-14
20688057-5	2010	After silencing of DLP1, an accumulation of the apical reporter protein YFP-GL-GPI, but not the basolateral reporter VSVG-SP-GFP at the Golgi complex was observed.	glycylleucine	76-78	dynamin 1 like	Homo sapiens	19-23
21526220-6	2011	According to epistasis studies with phosphorylation site-mutant dynamin-related protein 1 (Drp1), inhibition of the mitochondrial fission enzyme through a conserved PKA site is the principal mechanism by which cAMP and PKA/AKAP1 promote both mitochondrial elongation and neuronal survival.	Cyclic AMP	210-214	dynamin 1 like	Homo sapiens	64-89
21526220-6	2011	According to epistasis studies with phosphorylation site-mutant dynamin-related protein 1 (Drp1), inhibition of the mitochondrial fission enzyme through a conserved PKA site is the principal mechanism by which cAMP and PKA/AKAP1 promote both mitochondrial elongation and neuronal survival.	Cyclic AMP	210-214	dynamin 1 like	Homo sapiens	91-95
21526220-7	2011	Phenocopied by a mutation that slows GTP hydrolysis, Drp1 phosphorylation inhibits the disassembly step of its catalytic cycle, accumulating large, slowly recycling Drp1 oligomers at the OMM.	Guanosine Triphosphate	37-40	dynamin 1 like	Homo sapiens	53-57
21526220-7	2011	Phenocopied by a mutation that slows GTP hydrolysis, Drp1 phosphorylation inhibits the disassembly step of its catalytic cycle, accumulating large, slowly recycling Drp1 oligomers at the OMM.	Guanosine Triphosphate	37-40	dynamin 1 like	Homo sapiens	165-169
20467441-0	2010	Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation.	Nitric Oxide	0-12	dynamin 1 like	Homo sapiens	27-31
20060165-5	2010	Additionally, excessive calcium-induced NO generation leads to the formation of S-nitrosylated dynamin-related protein 1, which causes abnormal mitochondrial fragmentation and resultant synaptic damage.	Calcium	24-31	dynamin 1 like	Homo sapiens	95-120
20850011-4	2010	Here we show that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tethering and hemifusion of membranes in vitro.	tBID	34-38	dynamin 1 like	Homo sapiens	18-22
20850011-5	2010	This function of Drp1 is independent of its GTPase activity and relies on arginine 247 and the presence of cardiolipin in membranes.	Arginine	74-82	dynamin 1 like	Homo sapiens	17-21
20428767-7	2010	In the present study, we observed that increasing mitochondrial calcium induced mitochondrial fragmentation, which correlated with the presence of Drp1 at the mitochondria in CGP treated cells.	Calcium	64-71	dynamin 1 like	Homo sapiens	147-151
19492085-8	2009	We also show that Drp1 is dephosphorylated in PINK1 deficient cells due to activation of the calcium-dependent phosphatase calcineurin.	Calcium	93-100	dynamin 1 like	Homo sapiens	18-22
19638400-1	2009	Dynamin-related protein (Drp) 1 is a key regulator of mitochondrial fission and is composed of GTP-binding, Middle, insert B, and C-terminal GTPase effector (GED) domains.	Guanosine Triphosphate	95-98	dynamin 1 like	Homo sapiens	0-31
19525928-11	2009	Antibodies specific to DRP1 co-precipitated a human homologue of yeast Rad23 protein A (hHR23A) and silencing of hHR23A decreased the nuclear DRP1 level and cisplatin resistance.	Cisplatin	157-166	dynamin 1 like	Homo sapiens	23-27
20463395-4	2010	A recent article claimed that S-nitrosylation of dynamin related protein 1 (DRP1) at cysteine 644 causes protein dimerization and increased GTPase activity and is the mechanism responsible for NO-induced mitochondrial fission and neuronal injury in AD, but not in Parkinson"s disease (PD).	Cysteine	85-93	dynamin 1 like	Homo sapiens	49-74
20463395-4	2010	A recent article claimed that S-nitrosylation of dynamin related protein 1 (DRP1) at cysteine 644 causes protein dimerization and increased GTPase activity and is the mechanism responsible for NO-induced mitochondrial fission and neuronal injury in AD, but not in Parkinson"s disease (PD).	Cysteine	85-93	dynamin 1 like	Homo sapiens	76-80
20463395-12	2010	Finally, we show that NO triggers DRP1 phosphorylation at serine 616, which results in its activation and recruitment to mitochondria.	Serine	58-64	dynamin 1 like	Homo sapiens	34-38
19638400-6	2009	Although initial analysis indicates that mitochondrial recruitment of ectopically expressed Drp1 in response to staurosporine is unaffected by loss of SUMOylation, we find that Drp1 SUMOylation is enhanced in the context of the K38A mutation.	Staurosporine	112-125	dynamin 1 like	Homo sapiens	92-96
19492085-9	2009	Accordingly, the calcineurin inhibitor FK506 blocks both Drp1 dephosphorylation and loss of mitochondrial integrity in PINK1 deficient cells but does not fully rescue mitochondrial membrane potential.	Tacrolimus	39-44	dynamin 1 like	Homo sapiens	57-61
17721437-2	2007	Dynamin-related protein 1 (Drp1) is an ancient mechanoenzyme that uses GTP hydrolysis to power the constriction and division of mitochondria.	Guanosine Triphosphate	71-74	dynamin 1 like	Homo sapiens	0-25
19342591-5	2009	We found that nitric oxide produced in response to beta-amyloid protein, thought to be a key mediator of Alzheimer"s disease, triggered mitochondrial fission, synaptic loss, and neuronal damage, in part via S-nitrosylation of dynamin-related protein 1 (forming SNO-Drp1).	Nitric Oxide	14-26	dynamin 1 like	Homo sapiens	226-251
19342591-5	2009	We found that nitric oxide produced in response to beta-amyloid protein, thought to be a key mediator of Alzheimer"s disease, triggered mitochondrial fission, synaptic loss, and neuronal damage, in part via S-nitrosylation of dynamin-related protein 1 (forming SNO-Drp1).	Nitric Oxide	14-26	dynamin 1 like	Homo sapiens	265-269
19342591-6	2009	Preventing nitrosylation of Drp1 by cysteine mutation abrogated these neurotoxic events.	Cysteine	36-44	dynamin 1 like	Homo sapiens	28-32
18805504-0	2009	Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis.	Glucose	40-47	dynamin 1 like	Homo sapiens	0-25
18805504-3	2009	In this study, we reported that a mitochondrial fission modulator, Dynamin-related protein 1 (Drp-1), plays an important role in high glucose induced beta cell apoptosis.	Glucose	134-141	dynamin 1 like	Homo sapiens	67-92
18805504-3	2009	In this study, we reported that a mitochondrial fission modulator, Dynamin-related protein 1 (Drp-1), plays an important role in high glucose induced beta cell apoptosis.	Glucose	134-141	dynamin 1 like	Homo sapiens	94-99
18805504-5	2009	Induction of Drp-1 expression significantly promoted high glucose induced apoptosis in Drp-1WT (Drp-1 wild type) inducible beta cell line, but not in Drp-1K38A (a dominant negative mutant of Drp1) inducible beta cell line.	Glucose	58-65	dynamin 1 like	Homo sapiens	13-18
18805504-5	2009	Induction of Drp-1 expression significantly promoted high glucose induced apoptosis in Drp-1WT (Drp-1 wild type) inducible beta cell line, but not in Drp-1K38A (a dominant negative mutant of Drp1) inducible beta cell line.	Glucose	58-65	dynamin 1 like	Homo sapiens	87-92
18805504-7	2009	These results indicated that Drp-1 mediates high glucose induced pancreatic beta cell apoptosis.	Glucose	49-56	dynamin 1 like	Homo sapiens	29-34
19147562-11	2009	Our results further show that Drp1 accumulates in mitochondria and mediates the signal of doxorubicin to induce mitochondrial fission.	Doxorubicin	90-101	dynamin 1 like	Homo sapiens	30-34
19426871-2	2009	Similar to the endocytosis motor dynamin, Drp1 uses GTP hydrolysis to power constriction of the outer mitochondrial membrane and ultimately mitochondrial division.	Guanosine Triphosphate	52-55	dynamin 1 like	Homo sapiens	42-46
18845145-2	2008	DLP1 mediates the scission of mitochondrial membranes through GTP hydrolysis, and hFis1 is a putative DLP1 receptor anchored at the mitochondrial outer membrane by a C-terminal single transmembrane domain.	Guanosine Triphosphate	62-65	dynamin 1 like	Homo sapiens	0-4
18838687-5	2008	Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis.	Serine	84-90	dynamin 1 like	Homo sapiens	43-47
18695047-5	2008	VDCC-associated Ca2+ signaling stimulates phosphorylation of dynamin-related protein 1 (Drp1) at serine 600 via activation of Ca2+/calmodulin-dependent protein kinase Ialpha (CaMKIalpha).	Serine	97-103	dynamin 1 like	Homo sapiens	61-86
18695047-5	2008	VDCC-associated Ca2+ signaling stimulates phosphorylation of dynamin-related protein 1 (Drp1) at serine 600 via activation of Ca2+/calmodulin-dependent protein kinase Ialpha (CaMKIalpha).	Serine	97-103	dynamin 1 like	Homo sapiens	88-92
18695047-6	2008	In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1.	Serine	54-60	dynamin 1 like	Homo sapiens	46-50
18695047-6	2008	In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1.	Serine	54-60	dynamin 1 like	Homo sapiens	99-103
18695047-6	2008	In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1.	Serine	54-60	dynamin 1 like	Homo sapiens	99-103
18395527-0	2008	6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.	Oxidopamine	0-17	dynamin 1 like	Homo sapiens	35-39
18395527-0	2008	6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.	Oxidopamine	19-25	dynamin 1 like	Homo sapiens	35-39
18395527-3	2008	By immunofluorescence and time-lapse fluorescence microscopy we demonstrated that 6-OHDA induced profound mitochondrial fragmentation in SH-SY5Y cells, an event that was similar to mitochondrial fission induced by overexpression of Fis1p, a membrane adaptor for the dynamin-related protein 1 (DLP1/Drp1).	Oxidopamine	82-88	dynamin 1 like	Homo sapiens	266-291
18395527-3	2008	By immunofluorescence and time-lapse fluorescence microscopy we demonstrated that 6-OHDA induced profound mitochondrial fragmentation in SH-SY5Y cells, an event that was similar to mitochondrial fission induced by overexpression of Fis1p, a membrane adaptor for the dynamin-related protein 1 (DLP1/Drp1).	Oxidopamine	82-88	dynamin 1 like	Homo sapiens	293-297
18395527-3	2008	By immunofluorescence and time-lapse fluorescence microscopy we demonstrated that 6-OHDA induced profound mitochondrial fragmentation in SH-SY5Y cells, an event that was similar to mitochondrial fission induced by overexpression of Fis1p, a membrane adaptor for the dynamin-related protein 1 (DLP1/Drp1).	Oxidopamine	82-88	dynamin 1 like	Homo sapiens	298-302
18395527-6	2008	Silencing of DLP1/Drp1, which is involved in mitochondrial and peroxisomal fission, prevented 6-OHDA-induced fragmentation of mitochondria.	Oxidopamine	94-100	dynamin 1 like	Homo sapiens	13-17
18395527-6	2008	Silencing of DLP1/Drp1, which is involved in mitochondrial and peroxisomal fission, prevented 6-OHDA-induced fragmentation of mitochondria.	Oxidopamine	94-100	dynamin 1 like	Homo sapiens	18-22
18395527-7	2008	Furthermore, in cells silenced for Drp1, 6-OHDA-induced cell death was reduced, indicating that a block in mitochondrial fission protects SH-SY5Y cells against 6-OHDA toxicity.	Oxidopamine	41-47	dynamin 1 like	Homo sapiens	35-39
18395527-7	2008	Furthermore, in cells silenced for Drp1, 6-OHDA-induced cell death was reduced, indicating that a block in mitochondrial fission protects SH-SY5Y cells against 6-OHDA toxicity.	Oxidopamine	160-166	dynamin 1 like	Homo sapiens	35-39
18395527-9	2008	Our data demonstrate for the first time an involvement of mitochondrial fragmentation and Drp1 function in 6-OHDA-induced apoptosis.	Oxidopamine	107-113	dynamin 1 like	Homo sapiens	90-94
19417214-3	2009	Nitric oxide (NO) produced in response to Abeta induces S-nitrosylation of the mitochondrial division protein, dynamin-related protein 1 (Drp-1), which leads to excessive mitochondrial fission, synaptic loss, and neuronal damage.	Nitric Oxide	0-12	dynamin 1 like	Homo sapiens	111-136
19417214-3	2009	Nitric oxide (NO) produced in response to Abeta induces S-nitrosylation of the mitochondrial division protein, dynamin-related protein 1 (Drp-1), which leads to excessive mitochondrial fission, synaptic loss, and neuronal damage.	Nitric Oxide	0-12	dynamin 1 like	Homo sapiens	138-143
17721437-2	2007	Dynamin-related protein 1 (Drp1) is an ancient mechanoenzyme that uses GTP hydrolysis to power the constriction and division of mitochondria.	Guanosine Triphosphate	71-74	dynamin 1 like	Homo sapiens	27-31
17721437-8	2007	Thus, Drp1 phosphorylation at Ser 656 provides a mechanism for the integration of cAMP and calcium signals in the control of mitochondrial shape, apoptosis and other aspects of mitochondrial function.	Serine	30-33	dynamin 1 like	Homo sapiens	6-10
17721437-8	2007	Thus, Drp1 phosphorylation at Ser 656 provides a mechanism for the integration of cAMP and calcium signals in the control of mitochondrial shape, apoptosis and other aspects of mitochondrial function.	Cyclic AMP	82-86	dynamin 1 like	Homo sapiens	6-10
17721437-8	2007	Thus, Drp1 phosphorylation at Ser 656 provides a mechanism for the integration of cAMP and calcium signals in the control of mitochondrial shape, apoptosis and other aspects of mitochondrial function.	Calcium	91-98	dynamin 1 like	Homo sapiens	6-10
15469833-3	2004	in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.	Calcium	153-160	dynamin 1 like	Homo sapiens	54-79
17682056-5	2007	Once in mitochondria, Drp1 provokes an impairment of the mitochondrial electron transport chain, which results in dissipation of mitochondrial transmembrane potential, reactive oxygen species generation, and a drop in ATP levels.	Reactive Oxygen Species	168-191	dynamin 1 like	Homo sapiens	22-26
17682056-5	2007	Once in mitochondria, Drp1 provokes an impairment of the mitochondrial electron transport chain, which results in dissipation of mitochondrial transmembrane potential, reactive oxygen species generation, and a drop in ATP levels.	Adenosine Triphosphate	218-221	dynamin 1 like	Homo sapiens	22-26
16874299-7	2006	Mitofusin 1 (Mfn1) or dominant-negative Dynamin related protein 1 (Drp1(K38A)) inhibits mitochondrial fission induced by NO, rotenone and Amyloid-beta peptide.	Rotenone	125-133	dynamin 1 like	Homo sapiens	40-65
16874299-7	2006	Mitofusin 1 (Mfn1) or dominant-negative Dynamin related protein 1 (Drp1(K38A)) inhibits mitochondrial fission induced by NO, rotenone and Amyloid-beta peptide.	Rotenone	125-133	dynamin 1 like	Homo sapiens	67-71
17443673-7	2007	We were able to block the TG-induced mitochondrial fragmentation by inhibiting mitochondrial fission proteins DLP1/Drp1 or hFis1, suggesting that increased mitochondrial Ca(2+) acts upstream to activate the cellular mitochondrial fission machinery.	Thapsigargin	26-28	dynamin 1 like	Homo sapiens	110-114
17553808-6	2007	Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity.	Cyclic AMP	25-29	dynamin 1 like	Homo sapiens	84-88
17553808-6	2007	Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity.	Cyclic AMP	25-29	dynamin 1 like	Homo sapiens	137-141
17553808-6	2007	Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity.	Serine	114-117	dynamin 1 like	Homo sapiens	84-88
17553808-6	2007	Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity.	Serine	114-117	dynamin 1 like	Homo sapiens	137-141
17553808-7	2007	Mechanistically, this change in GTPase activity likely derives from decreased interaction of GTP-binding/middle domains with the GED domain since the phosphomimetic S637D mutation impairs this intramolecular interaction but not Drp1-Drp1 intermolecular interactions.	Guanosine Triphosphate	32-35	dynamin 1 like	Homo sapiens	228-232
17553808-7	2007	Mechanistically, this change in GTPase activity likely derives from decreased interaction of GTP-binding/middle domains with the GED domain since the phosphomimetic S637D mutation impairs this intramolecular interaction but not Drp1-Drp1 intermolecular interactions.	Guanosine Triphosphate	32-35	dynamin 1 like	Homo sapiens	233-237
17553808-9	2007	Thus, protein phosphorylation at Ser(637) results in clear alterations in Drp1 function and mitochondrial morphology that are likely involved in dynamic regulation of mitochondrial division in cells.	Serine	33-36	dynamin 1 like	Homo sapiens	74-78
17301055-6	2007	Drp1 was specifically phosphorylated in mitosis by Cdk1/cyclin B on Ser-585.	Serine	68-71	dynamin 1 like	Homo sapiens	0-4
17301055-8	2007	These results suggest that phosphorylation of Drp1 on Ser-585 promotes mitochondrial fission in mitotic cells.	Serine	54-57	dynamin 1 like	Homo sapiens	46-50
15469822-4	2004	Consequently, in Drp-1-expressing cells the apoptotic efficacy of ceramide, which causes a Ca2+-dependent perturbation of mitochondrial structure and function, was drastically reduced.	Ceramides	66-74	dynamin 1 like	Homo sapiens	17-22
15469822-5	2004	Conversely, the sensitivity to staurosporine-induced apoptosis, previously shown to be directly triggered by Drp-1-dependent recruitment of proapoptotic proteins to mitochondria, was enhanced.	Staurosporine	31-44	dynamin 1 like	Homo sapiens	109-114
15469833-3	2004	in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.	Calcium	153-160	dynamin 1 like	Homo sapiens	81-85
15208300-3	2004	Functional studies and sequence comparisons have revealed four different structural domains in Drp1, comprising N-terminal GTP-binding, middle, insert B, and C-terminal GTPase effector (GED) domains.	Guanosine Triphosphate	123-126	dynamin 1 like	Homo sapiens	95-99
15208300-4	2004	Here we describe an intramolecular interaction within Drp1 between the GED and the N-terminal GTP-binding and middle domains.	Guanosine Triphosphate	94-97	dynamin 1 like	Homo sapiens	54-58
10902754-6	2000	Their sera were considered to mainly recognize the N-terminus of dymple, which contains GTP-binding motifs.	Guanosine Triphosphate	88-91	dynamin 1 like	Homo sapiens	65-71
15286177-2	2004	We have previously shown that the expression of a dominant-negative DLP1 mutant deficient in GTP hydrolysis (K38A) inhibited peroxisomal division in mammalian cells.	Guanosine Triphosphate	93-96	dynamin 1 like	Homo sapiens	68-72
15286177-3	2004	In this study, we conducted RNA interference experiments to "knock down" the expression of DLP1 in COS-7 cells stably expressing a GFP construct bearing the C-terminal peroxisomal targeting signal 1.	carbonyl sulfide	99-102	dynamin 1 like	Homo sapiens	91-95
12499366-5	2003	Expression of a dominant negative DLP1 mutant deficient in GTP hydrolysis (K38A) either alone or in combination with Pex11pbeta caused the appearance of tubular peroxisomes but had no influence on their intracellular distribution.	Guanosine Triphosphate	59-62	dynamin 1 like	Homo sapiens	34-38
11553726-7	2001	Biochemical experiments with the use of recombinant DLP1 and labeled GTP demonstrated that DLP1-K38A binds but does not hydrolyze or release GTP.	Guanosine Triphosphate	69-72	dynamin 1 like	Homo sapiens	91-95
11553726-10	2001	We found that DLP1 protein alone assembled into sedimentable macromolecular structures in the presence of guanosine-5"-O-(3-thio)triphosphate (GTPgammaS) but not GTP.	Guanosine 5'-O-(3-Thiotriphosphate)	106-141	dynamin 1 like	Homo sapiens	14-18
11553726-10	2001	We found that DLP1 protein alone assembled into sedimentable macromolecular structures in the presence of guanosine-5"-O-(3-thio)triphosphate (GTPgammaS) but not GTP.	Guanosine 5'-O-(3-Thiotriphosphate)	143-152	dynamin 1 like	Homo sapiens	14-18
11553726-10	2001	We found that DLP1 protein alone assembled into sedimentable macromolecular structures in the presence of guanosine-5"-O-(3-thio)triphosphate (GTPgammaS) but not GTP.	Guanosine Triphosphate	143-146	dynamin 1 like	Homo sapiens	14-18
11553726-13	2001	Addition of GTPgammaS greatly enhanced membrane tubule formation, suggesting the GTP-bound form of DLP1 deforms liposomes into tubules as the DLP1-K38A does in vivo.	Guanosine Triphosphate	12-15	dynamin 1 like	Homo sapiens	99-103
11553726-13	2001	Addition of GTPgammaS greatly enhanced membrane tubule formation, suggesting the GTP-bound form of DLP1 deforms liposomes into tubules as the DLP1-K38A does in vivo.	Guanosine Triphosphate	12-15	dynamin 1 like	Homo sapiens	142-146
9731200-3	1998	When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV"s carboxyl terminal lacks a proline-rich domain that can bind to Gsk-3 beta.	Proline	101-108	dynamin 1 like	Homo sapiens	29-35
10588666-5	1999	Point mutations in the GTP-binding domain of DLP1 (K38A and D231N) dramatically changed its intracellular distribution from punctate vesicular structures to either an aggregated or a diffuse pattern.	Guanosine Triphosphate	23-26	dynamin 1 like	Homo sapiens	45-49
9731200-3	1998	When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV"s carboxyl terminal lacks a proline-rich domain that can bind to Gsk-3 beta.	Proline	101-108	dynamin 1 like	Homo sapiens	66-72
33971394-4	2021	In the present study, we found that Cr(VI) induced phosphorylation of dynamin-relatedprotein 1 (Drp1)-S637 site in premature senescent cells, which was accompanied with the decrease of mitochondrial fission.	chromium hexavalent ion	36-42	dynamin 1 like	Homo sapiens	70-94
9422767-0	1998	Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.	Proline	68-75	dynamin 1 like	Homo sapiens	0-6
9422767-4	1998	Dymple lacks a proline-rich carboxyl-terminal domain through which dynamin binds to SH3 domains to be activated.	Proline	15-22	dynamin 1 like	Homo sapiens	0-6
33971394-4	2021	In the present study, we found that Cr(VI) induced phosphorylation of dynamin-relatedprotein 1 (Drp1)-S637 site in premature senescent cells, which was accompanied with the decrease of mitochondrial fission.	chromium hexavalent ion	36-42	dynamin 1 like	Homo sapiens	96-100
33971394-5	2021	We also demonstrated that the phosphorylation status of Drp1-S637 after Cr(VI) exposure was related to the antagonism of PKA/PP2B, and continuous dephosphorylation of Drp1-S637 attenuated premature senescence caused by Cr(VI).	chromium hexavalent ion	72-78	dynamin 1 like	Homo sapiens	56-60
33971394-5	2021	We also demonstrated that the phosphorylation status of Drp1-S637 after Cr(VI) exposure was related to the antagonism of PKA/PP2B, and continuous dephosphorylation of Drp1-S637 attenuated premature senescence caused by Cr(VI).	chromium hexavalent ion	72-78	dynamin 1 like	Homo sapiens	167-171
33971394-5	2021	We also demonstrated that the phosphorylation status of Drp1-S637 after Cr(VI) exposure was related to the antagonism of PKA/PP2B, and continuous dephosphorylation of Drp1-S637 attenuated premature senescence caused by Cr(VI).	chromium hexavalent ion	219-225	dynamin 1 like	Homo sapiens	56-60
33971394-5	2021	We also demonstrated that the phosphorylation status of Drp1-S637 after Cr(VI) exposure was related to the antagonism of PKA/PP2B, and continuous dephosphorylation of Drp1-S637 attenuated premature senescence caused by Cr(VI).	chromium hexavalent ion	219-225	dynamin 1 like	Homo sapiens	167-171
33971394-7	2021	In brief, we revealed the role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.	chromium hexavalent ion	111-117	dynamin 1 like	Homo sapiens	52-56
33805672-3	2021	Inhibitors of ETC complex I (rotenone, ROT) and complex III (antimycin A, AA) decreased the phosphorylation of Plk1 T210 and Aurora A T288 in the mitotic phase (M-phase), especially ROT, affecting the dynamic phosphorylation status of fission protein dynamin-related protein 1 (Drp1) and the Ser637/Ser616 ratio.	Rotenone	29-37	dynamin 1 like	Homo sapiens	251-276
33805672-3	2021	Inhibitors of ETC complex I (rotenone, ROT) and complex III (antimycin A, AA) decreased the phosphorylation of Plk1 T210 and Aurora A T288 in the mitotic phase (M-phase), especially ROT, affecting the dynamic phosphorylation status of fission protein dynamin-related protein 1 (Drp1) and the Ser637/Ser616 ratio.	Rotenone	29-37	dynamin 1 like	Homo sapiens	278-282
33805672-3	2021	Inhibitors of ETC complex I (rotenone, ROT) and complex III (antimycin A, AA) decreased the phosphorylation of Plk1 T210 and Aurora A T288 in the mitotic phase (M-phase), especially ROT, affecting the dynamic phosphorylation status of fission protein dynamin-related protein 1 (Drp1) and the Ser637/Ser616 ratio.	Antimycin A	61-72	dynamin 1 like	Homo sapiens	251-276
33805672-3	2021	Inhibitors of ETC complex I (rotenone, ROT) and complex III (antimycin A, AA) decreased the phosphorylation of Plk1 T210 and Aurora A T288 in the mitotic phase (M-phase), especially ROT, affecting the dynamic phosphorylation status of fission protein dynamin-related protein 1 (Drp1) and the Ser637/Ser616 ratio.	Antimycin A	61-72	dynamin 1 like	Homo sapiens	278-282
33802063-8	2021	These results suggest that NAD+-mediated SIRT1 activation facilitates mitochondrial fission through activation of Drp1 by suppressing its phosphorylation and accelerating its dephosphorylation.	NAD	27-31	dynamin 1 like	Homo sapiens	114-118
32796068-4	2020	Here, we observed that treatment of human primary neurons (HPNs) with methamphetamine and HIV gp120 and Tat increase dynamin-related protein (DRP1)-dependent mitochondrial fragmentation and neuronal degeneration.	Methamphetamine	70-85	dynamin 1 like	Homo sapiens	142-146
33802063-0	2021	Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca2.	Niacinamide	0-12	dynamin 1 like	Homo sapiens	65-69
33802063-5	2021	NAM treatment induced mitochondrial fission, at least in part by activating dynamin-1-like protein (Drp1), and this was through attenuation of the inhibitory phosphorylation at serine 637 (S637) of Drp1.	Niacinamide	0-3	dynamin 1 like	Homo sapiens	76-98
33802063-5	2021	NAM treatment induced mitochondrial fission, at least in part by activating dynamin-1-like protein (Drp1), and this was through attenuation of the inhibitory phosphorylation at serine 637 (S637) of Drp1.	Niacinamide	0-3	dynamin 1 like	Homo sapiens	100-104
33802063-5	2021	NAM treatment induced mitochondrial fission, at least in part by activating dynamin-1-like protein (Drp1), and this was through attenuation of the inhibitory phosphorylation at serine 637 (S637) of Drp1.	Niacinamide	0-3	dynamin 1 like	Homo sapiens	198-202
33802063-5	2021	NAM treatment induced mitochondrial fission, at least in part by activating dynamin-1-like protein (Drp1), and this was through attenuation of the inhibitory phosphorylation at serine 637 (S637) of Drp1.	Serine	177-183	dynamin 1 like	Homo sapiens	198-202
33802063-6	2021	This Drp1 hypo-phosphorylation was attributed to SIRT1-mediated activation of AMP-activated protein kinase (AMPK), which in turn induced a decrease in cellular levels of cyclic AMP (cAMP) and protein kinase A (PKA) activity, a kinase targeting S637 of Drp1.	Cyclic AMP	170-180	dynamin 1 like	Homo sapiens	5-9
33802063-6	2021	This Drp1 hypo-phosphorylation was attributed to SIRT1-mediated activation of AMP-activated protein kinase (AMPK), which in turn induced a decrease in cellular levels of cyclic AMP (cAMP) and protein kinase A (PKA) activity, a kinase targeting S637 of Drp1.	Cyclic AMP	182-186	dynamin 1 like	Homo sapiens	5-9
33236140-0	2021	Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts.	bleomycetin	0-12	dynamin 1 like	Homo sapiens	24-28
33236140-8	2021	Dynamin-related protein 1 (Drp1) was shown to be altered in BLE-A5-treated NPDFs.	npdfs	75-80	dynamin 1 like	Homo sapiens	0-25
33236140-8	2021	Dynamin-related protein 1 (Drp1) was shown to be altered in BLE-A5-treated NPDFs.	npdfs	75-80	dynamin 1 like	Homo sapiens	27-31
32796068-7	2020	N-acetylcysteine (NAC), a strong antioxidant and ROS scavenger, abrogated DRP1-dependent mitochondrial fragmentation and neurite degeneration.	Acetylcysteine	0-16	dynamin 1 like	Homo sapiens	74-78
32796068-7	2020	N-acetylcysteine (NAC), a strong antioxidant and ROS scavenger, abrogated DRP1-dependent mitochondrial fragmentation and neurite degeneration.	Acetylcysteine	18-21	dynamin 1 like	Homo sapiens	74-78
32796068-7	2020	N-acetylcysteine (NAC), a strong antioxidant and ROS scavenger, abrogated DRP1-dependent mitochondrial fragmentation and neurite degeneration.	Reactive Oxygen Species	49-52	dynamin 1 like	Homo sapiens	74-78
34875338-13	2022	The calcineurin inhibitor FK506 exhibited a Drp1-independent function that mitigated mitochondrial dysfunction.	Tacrolimus	26-31	dynamin 1 like	Homo sapiens	44-48
32796068-10	2020	In this study, we show that in human primary neurons, the combination of HIV proteins and methamphetamine increase oxidative stress, DRP-1 mediated mitochondrial fragmentation and neuronal injury manifested by a reduction in neuronal network and connectivity.	Methamphetamine	90-105	dynamin 1 like	Homo sapiens	133-138
32782788-6	2020	Further analysis indicated that a DRP1 deficiency caused mitochondrial dysfunction and induced oxidative stress, which was confirmed by increased reactive oxygen species levels.	Oxygen	155-161	dynamin 1 like	Homo sapiens	34-38
34767958-9	2022	RESULTS: Expression of DRP1 and mitochondrial damage was high in human OA cartilage and in the joints of mice subjected to DMM surgery which also showed increased chondrocytes apoptosis.	dimethylmyleran	123-126	dynamin 1 like	Homo sapiens	23-27
34801855-0	2022	Baicalein suppresses lipopolysaccharide-induced acute lung injury by regulating Drp1-dependent mitochondrial fission of macrophages.	baicalein	0-9	dynamin 1 like	Homo sapiens	80-84
34801855-11	2022	Taken together, our results show that baicalein may serve as a new clinical therapeutic strategy in ALI by modulating Drp1-induced mitochondrial impairment, restraining inflammatory responses, and reducing the severity of lung injury.	baicalein	38-47	dynamin 1 like	Homo sapiens	118-122
34462274-5	2022	Mechanistically, dynamin-related protein 1 (DRP1)-dependent excessive mitochondrial fragmentation in HSC/Ps led to excessive ROS production, induced inflammatory signaling activation, and promoted subsequent dysplasia formation and impairment of granulopoiesis.	ros	125-128	dynamin 1 like	Homo sapiens	17-42
34462274-5	2022	Mechanistically, dynamin-related protein 1 (DRP1)-dependent excessive mitochondrial fragmentation in HSC/Ps led to excessive ROS production, induced inflammatory signaling activation, and promoted subsequent dysplasia formation and impairment of granulopoiesis.	ros	125-128	dynamin 1 like	Homo sapiens	44-48
34757590-7	2022	Furthermore, pTau-S396 interacted with DRP1, and similar to pTau-S396, DRP1 accumulated in SNs across ALS subtypes, suggesting increases in mitochondrial fragmentation in ALS.	ptau	13-17	dynamin 1 like	Homo sapiens	39-43
34757590-7	2022	Furthermore, pTau-S396 interacted with DRP1, and similar to pTau-S396, DRP1 accumulated in SNs across ALS subtypes, suggesting increases in mitochondrial fragmentation in ALS.	ptau	13-17	dynamin 1 like	Homo sapiens	71-75
34757590-13	2022	pTau-S396 interacts with the pro-fission GTPase DRP1 in ALS.	ptau	0-4	dynamin 1 like	Homo sapiens	48-52
34757590-13	2022	pTau-S396 interacts with the pro-fission GTPase DRP1 in ALS.	C21H42O8	5-9	dynamin 1 like	Homo sapiens	48-52
34965411-5	2021	In parallel, downregulation of SIRT2 hyperacetylates the serine/threonine protein kinase AKT1 at Lys20 in a non-canonical way, activating DRP1 and metabolic reprogramming.	Serine	57-63	dynamin 1 like	Homo sapiens	138-142
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	dynamin 1 like	Homo sapiens	0-4
34741026-5	2021	Firstly, mitochondrial Drp1 maximumly recognizes mPTP channels by binding Bcl-2-associated X protein (BAX) and a phosphate carrier protein (PiC) in the mPTP.	Phosphates	113-122	dynamin 1 like	Homo sapiens	23-27
34963686-8	2021	Mechanistically, CPT1A overexpression increased the phosphorylation of dynamin-related protein 1 at Ser-637 to promote mitochondrial fusion.	Serine	100-103	dynamin 1 like	Homo sapiens	71-96
34725875-10	2021	More specifically, AR up-regulated the phosphorylation of Drp1 at Serine 637 by activating AMP-activated protein kinase (AMPK), thereby inhibiting the mitochondrial translocation of Drp1.	Serine	66-72	dynamin 1 like	Homo sapiens	58-62
34873283-6	2021	Moreover, we define key biogenesis steps of phosphatidic acid-enriched MDVs starting with the MIRO1/2-dependent formation of thin membrane protrusions pulled along microtubule filaments, followed by MID49/MID51/MFF-dependent recruitment of the dynamin family GTPase DRP1 and finally DRP1-dependent scission.	Phosphatidic Acids	44-61	dynamin 1 like	Homo sapiens	266-270
34873283-6	2021	Moreover, we define key biogenesis steps of phosphatidic acid-enriched MDVs starting with the MIRO1/2-dependent formation of thin membrane protrusions pulled along microtubule filaments, followed by MID49/MID51/MFF-dependent recruitment of the dynamin family GTPase DRP1 and finally DRP1-dependent scission.	Phosphatidic Acids	44-61	dynamin 1 like	Homo sapiens	283-287
34888014-11	2021	In JEG3 cells treated with 30 mmol/L glucose, the mRNA and protein expression of p66Shc and Drp1 were increased at 24 h (both P < 0.05), 48 h (both P < 0.01) and 72 h (both P < 0.001).	Glucose	37-44	dynamin 1 like	Homo sapiens	92-96
34769322-5	2021	NaHS improved the mitochondrial membrane potential and attenuated oxidative stress, and inhibited dynamin-related protein 1 (DRP1), but enhanced optic atrophy protein 1 (OPA1) expression.	sodium bisulfide	0-4	dynamin 1 like	Homo sapiens	98-123
34769322-5	2021	NaHS improved the mitochondrial membrane potential and attenuated oxidative stress, and inhibited dynamin-related protein 1 (DRP1), but enhanced optic atrophy protein 1 (OPA1) expression.	sodium bisulfide	0-4	dynamin 1 like	Homo sapiens	125-129
34685760-4	2021	Treating neurons with okadaic acid (OA), an inhibitor of phosphatases PP1 and PP2A, resulted in increased CRMP2 phosphorylation at Thr509/514, Ser522, and Thr555, and augmented Drp1 phosphorylation at Ser616.	Okadaic Acid	22-34	dynamin 1 like	Homo sapiens	177-181
34685760-7	2021	(S)-LCM rescued CRMP2 binding to Drp1 and Miro 2 but not to KLC1.	Lincomycin	0-7	dynamin 1 like	Homo sapiens	33-37
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	dynamin 1 like	Homo sapiens	106-110
34722538-5	2021	Here we demonstrate that preventing Drp1 SUMOylation by mutating its SUMO target lysines enhances the Drp1-Bcl-x L interaction in vivo and in vitro.	Lysine	81-88	dynamin 1 like	Homo sapiens	36-40
34722538-5	2021	Here we demonstrate that preventing Drp1 SUMOylation by mutating its SUMO target lysines enhances the Drp1-Bcl-x L interaction in vivo and in vitro.	Lysine	81-88	dynamin 1 like	Homo sapiens	102-106
34403210-4	2021	Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637.	Serine	142-148	dynamin 1 like	Homo sapiens	106-131
34403210-4	2021	Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637.	Serine	142-148	dynamin 1 like	Homo sapiens	133-137
34403210-4	2021	Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637.	Serine	194-200	dynamin 1 like	Homo sapiens	186-190
34403210-7	2021	PD325901 and Mdivi-1 inhibited phosphorylation of Drp1 at serine 616, resulting in reduced mitochondrial fission under hypoxia.	mirdametinib	0-8	dynamin 1 like	Homo sapiens	50-54
34403210-7	2021	PD325901 and Mdivi-1 inhibited phosphorylation of Drp1 at serine 616, resulting in reduced mitochondrial fission under hypoxia.	Serine	58-64	dynamin 1 like	Homo sapiens	50-54
34529976-0	2021	Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.	Calcium	117-124	dynamin 1 like	Homo sapiens	0-25
34529976-5	2021	Loss of DRP1 (shDRP1) resulted in extensive ultrastructural and functional remodeling of mitochondria, characterized by pleomorphic enlargement, increased electron density of the matrix, and defective NADH and succinate oxidation.	NAD	201-205	dynamin 1 like	Homo sapiens	8-12
34529976-5	2021	Loss of DRP1 (shDRP1) resulted in extensive ultrastructural and functional remodeling of mitochondria, characterized by pleomorphic enlargement, increased electron density of the matrix, and defective NADH and succinate oxidation.	Succinic Acid	210-219	dynamin 1 like	Homo sapiens	8-12
34529976-8	2021	The insights obtained herein suggest that DRP1 regulates fatty acid oxidation by altering whole-cell and mitochondrial calcium dynamics.	Fatty Acids	57-67	dynamin 1 like	Homo sapiens	42-46
34529976-8	2021	The insights obtained herein suggest that DRP1 regulates fatty acid oxidation by altering whole-cell and mitochondrial calcium dynamics.	Calcium	119-126	dynamin 1 like	Homo sapiens	42-46
34089567-5	2021	Epimedium treatment promoted dynamin-associated protein 1 (Drp1)-mediated steroidogenesis pathway by upregulating PKA, CREB, Drp1, and StAR protein expression in response to ES exposure in Leydig cells.	Einsteinium	174-176	dynamin 1 like	Homo sapiens	59-63
34575980-5	2021	After 8 h, the highest dose of oleate induced a decrease in DRP1 content without changes in MFN2 content in association with cell viability maintenance, whereas palmitate induced a decrease in cell viability associated with a decrease mainly in MFN2 content.	Oleic Acid	31-37	dynamin 1 like	Homo sapiens	60-64
34575980-6	2021	After 24 h, oleate induced MFN2 increase, whereas palmitate induced DRP1 increase associated with a higher decrease in cell viability with high doses compared to oleate.	Palmitates	50-59	dynamin 1 like	Homo sapiens	68-72
34089567-5	2021	Epimedium treatment promoted dynamin-associated protein 1 (Drp1)-mediated steroidogenesis pathway by upregulating PKA, CREB, Drp1, and StAR protein expression in response to ES exposure in Leydig cells.	Einsteinium	174-176	dynamin 1 like	Homo sapiens	125-129
34384932-8	2021	The mitochondrial dynamics and morphology were impaired post miR-128 overexpression, as revealed by downregulation of fusion proteins (mitofusin1 and 2, i.e., MFN1 and MFN2, respectively) and upregulation of fission protein (dynamin-related protein 1, i.e., DRP1).	mir-128	61-68	dynamin 1 like	Homo sapiens	225-250
34384932-8	2021	The mitochondrial dynamics and morphology were impaired post miR-128 overexpression, as revealed by downregulation of fusion proteins (mitofusin1 and 2, i.e., MFN1 and MFN2, respectively) and upregulation of fission protein (dynamin-related protein 1, i.e., DRP1).	mir-128	61-68	dynamin 1 like	Homo sapiens	258-262
34589283-11	2021	Collectively, our data indicate that CMDL-1 may play an anti-apoptotic role in DOX cardiotoxicity by regulating Drp1 S637 phosphorylation.	Doxorubicin	79-82	dynamin 1 like	Homo sapiens	112-116
34362731-7	2021	Loss of PINK1 blocks Parkin recruitment, causes LC3 accumulation within mitochondria, and exacerbates Drp1KO toxicity to dopamine neurons.	Dopamine	121-129	dynamin 1 like	Homo sapiens	102-106
34254625-5	2021	Using human hepatocellular carcinoma (HepG2) cells, we confirmed that the interaction between dynamin-related protein 1 (DRP1)-dependent mitochondrial fission and oxidative stress promoted mitochondrial damage and mitochondria-dependent apoptosis induced by AgNPs, as determined by the elimination of DRP1 or addition of N-acetylcysteine (NAC).	Acetylcysteine	321-337	dynamin 1 like	Homo sapiens	121-125
34394840-11	2021	Interestingly, inhibition of TLR4 with TAK-242 promoted Drp1 downregulation and mitochondrial fusion.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	39-46	dynamin 1 like	Homo sapiens	56-60
34090870-5	2021	RESULTS: Overnight lipid infusion increased dynamin related protein 1 (DRP1) phosphorylation at serine 616 and PTEN-induced kinase 1 (PINK1) expression (P = 0.003 and P = 0.008, respectively) in skeletal muscle while reducing mitochondrial membrane potential (P = 0.042).	Serine	96-102	dynamin 1 like	Homo sapiens	44-69
34090870-5	2021	RESULTS: Overnight lipid infusion increased dynamin related protein 1 (DRP1) phosphorylation at serine 616 and PTEN-induced kinase 1 (PINK1) expression (P = 0.003 and P = 0.008, respectively) in skeletal muscle while reducing mitochondrial membrane potential (P = 0.042).	Serine	96-102	dynamin 1 like	Homo sapiens	71-75
34254625-5	2021	Using human hepatocellular carcinoma (HepG2) cells, we confirmed that the interaction between dynamin-related protein 1 (DRP1)-dependent mitochondrial fission and oxidative stress promoted mitochondrial damage and mitochondria-dependent apoptosis induced by AgNPs, as determined by the elimination of DRP1 or addition of N-acetylcysteine (NAC).	Acetylcysteine	339-342	dynamin 1 like	Homo sapiens	94-119
34254625-5	2021	Using human hepatocellular carcinoma (HepG2) cells, we confirmed that the interaction between dynamin-related protein 1 (DRP1)-dependent mitochondrial fission and oxidative stress promoted mitochondrial damage and mitochondria-dependent apoptosis induced by AgNPs, as determined by the elimination of DRP1 or addition of N-acetylcysteine (NAC).	Acetylcysteine	339-342	dynamin 1 like	Homo sapiens	121-125
34261790-3	2021	Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions.	Adenosine Diphosphate	196-199	dynamin 1 like	Homo sapiens	152-156
34261790-3	2021	Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions.	Adenosine Triphosphate	200-203	dynamin 1 like	Homo sapiens	152-156
34261790-5	2021	Importantly, VD membrane insertion and GTP-dependent conformational rearrangements mediate only transient CL nonbilayer topological forays and high local membrane constriction, indicating that Drp1-CL interactions alone are insufficient for fission.	Guanosine Triphosphate	39-42	dynamin 1 like	Homo sapiens	193-197
34281194-4	2021	Both reactive oxygen and nitrogen species are in excess in CS-A cells and when the mitochondrial translocation of DRP1 is inhibited a reduction of these species is observed together with a recovery of mitochondrial integrity and a significant decrease of apoptosis.	Nitrogen	25-33	dynamin 1 like	Homo sapiens	114-118
34187517-8	2021	Further, blunting Egr3 expression in D1-MSNs blocks cocaine-enhancement of the mitochondrial-associated transcriptional coactivator, peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha), and the mitochondrial fission molecule, dynamin related protein 1 (Drp1).	Cocaine	52-59	dynamin 1 like	Homo sapiens	247-272
34187517-8	2021	Further, blunting Egr3 expression in D1-MSNs blocks cocaine-enhancement of the mitochondrial-associated transcriptional coactivator, peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha), and the mitochondrial fission molecule, dynamin related protein 1 (Drp1).	Cocaine	52-59	dynamin 1 like	Homo sapiens	274-278
35234738-9	2022	Our study demonstrated exogenous H2S treatment dramatically suppressed TGF-beta1 induced AF proliferation, migration, and phenotypic transition by blockage of dynamin-related protein 1 (Drp1) mediated mitochondrial fission and regulated mtROS generation.	Deuterium	33-36	dynamin 1 like	Homo sapiens	159-184
34254625-0	2021	The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles.	Silver	121-127	dynamin 1 like	Homo sapiens	22-26
34254625-5	2021	Using human hepatocellular carcinoma (HepG2) cells, we confirmed that the interaction between dynamin-related protein 1 (DRP1)-dependent mitochondrial fission and oxidative stress promoted mitochondrial damage and mitochondria-dependent apoptosis induced by AgNPs, as determined by the elimination of DRP1 or addition of N-acetylcysteine (NAC).	Acetylcysteine	321-337	dynamin 1 like	Homo sapiens	94-119
34203664-9	2021	Here, we show that Flt3-ITD+ cells are sensitive to an IB-induced dynamin 1-like (Drp1)-p38-ROS pathway.	ros	92-95	dynamin 1 like	Homo sapiens	82-86
34069800-0	2021	Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells.	Fatty Acids	59-69	dynamin 1 like	Homo sapiens	34-38
34069800-4	2021	We inhibited mitochondrial fission by silencing dynamin-related protein 1(DRP1) and observed the shift in fatty acid storage-usage balance.	Fatty Acids	106-116	dynamin 1 like	Homo sapiens	48-73
34069800-4	2021	We inhibited mitochondrial fission by silencing dynamin-related protein 1(DRP1) and observed the shift in fatty acid storage-usage balance.	Fatty Acids	106-116	dynamin 1 like	Homo sapiens	74-78
35304783-7	2022	The expression of PGAM5 in JEG3 cells was up-regulated under hypoxia, which promoted dephosphorylation of Drp1 at Serine 637 residue, mitochondrial dysfunction (elevated ROS level and reduced mitochondrial membrane potential and ATP content) and cellular necroptosis (increased PI+ /Annexin V+ cells and decreased cell viability), accompanied by increased expression of necroptosis-relevant proteins; knockdown of PGAM5 attenuated these phenomena.	Serine	114-120	dynamin 1 like	Homo sapiens	106-110
34068960-0	2021	All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission.	Tretinoin	0-23	dynamin 1 like	Homo sapiens	34-38
34068960-5	2021	Our results showed that ATRA increases DRP1 protein levels, increases the localization of DRP1 to mitochondria in isolated mitochondrial preparations.	Tretinoin	24-28	dynamin 1 like	Homo sapiens	39-43
34068960-5	2021	Our results showed that ATRA increases DRP1 protein levels, increases the localization of DRP1 to mitochondria in isolated mitochondrial preparations.	Tretinoin	24-28	dynamin 1 like	Homo sapiens	90-94
34068960-8	2021	In conclusion, ATRA results in a pharmacologically mediated increase in the DRP1 protein.	Tretinoin	15-19	dynamin 1 like	Homo sapiens	76-80
35234738-9	2022	Our study demonstrated exogenous H2S treatment dramatically suppressed TGF-beta1 induced AF proliferation, migration, and phenotypic transition by blockage of dynamin-related protein 1 (Drp1) mediated mitochondrial fission and regulated mtROS generation.	Deuterium	33-36	dynamin 1 like	Homo sapiens	186-190
35234738-10	2022	Moreover, exogenous H2S reversed TGF-beta1 induced mitochondrial fission and AF activation by modulating Rho-associated protein kinase 1 (ROCK1) dependent phosphorylation of Drp1.	Deuterium	20-23	dynamin 1 like	Homo sapiens	174-178
35218392-0	2022	Metal-Binding Propensity in the Mitochondrial Dynamin-Related Protein 1.	Metals	0-5	dynamin 1 like	Homo sapiens	46-71
35234738-11	2022	In conclusion, our results suggested that exogenous H2S attenuates TGF-beta1 induced AF activation via suppression of Drp1-mediated mitochondrial fission in a ROCK1-dependent fashion.	Deuterium	52-55	dynamin 1 like	Homo sapiens	118-122
35218392-2	2022	In efforts to understand how such multivalent interactions regulate Drp1 functions, in vitro reconstitution schemes rely on recruiting soluble portions of the adaptors appended with genetically encoded polyhistidine tags onto membranes containing Ni2+-bound chelator lipids.	polyhistidine	202-215	dynamin 1 like	Homo sapiens	68-72
35440104-0	2022	Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.	flubendazole	0-12	dynamin 1 like	Homo sapiens	51-55
35218392-2	2022	In efforts to understand how such multivalent interactions regulate Drp1 functions, in vitro reconstitution schemes rely on recruiting soluble portions of the adaptors appended with genetically encoded polyhistidine tags onto membranes containing Ni2+-bound chelator lipids.	Nickel(2+)	247-251	dynamin 1 like	Homo sapiens	68-72
35218392-4	2022	Here, we find using chelator lipids and chelator beads that both native and recombinant Drp1 directly bind Ni2+ ions.	Nickel(2+)	107-111	dynamin 1 like	Homo sapiens	88-92
35218392-5	2022	Metal binding, therefore, represents a potential strategy to deplete or purify Drp1 from native tissue lysates.	Metals	0-5	dynamin 1 like	Homo sapiens	79-83
35218392-6	2022	Importantly, high concentrations of the metal in solution inhibit GTP hydrolysis and renders Drp1 inactive in membrane fission.	Metals	40-45	dynamin 1 like	Homo sapiens	93-97
35218392-7	2022	Together, our results emphasize a metal-binding propensity, which could significantly impact Drp1 functions.	Metals	34-39	dynamin 1 like	Homo sapiens	93-97
35606779-3	2022	METHODS: In this study, we prepared macrophage-derived exosomes laden with heptapeptide (Hep) as a dynamin-related protein-1 (Drp1)-fission 1 (Fis1) peptide inhibitor P110 to alleviate cerebral ischemia-reperfusion injury by reducing mitochondrial Drp1/Fis1 interaction-mediated astrocytic mitochondrial disorder and promoting the transfer of astrocyte-derived healthy mitochondria into neurons.	Cytidine Diphosphate	167-171	dynamin 1 like	Homo sapiens	99-124
35561839-5	2022	This was also true in human PBCMCs in vitro after pharmacological inhibition of Drp1.	pbcmcs	28-34	dynamin 1 like	Homo sapiens	80-84
35523103-1	2022	BACKGROUND: Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission and is activated by phosphorylation at serine 616.	Serine	128-134	dynamin 1 like	Homo sapiens	12-37
35523103-1	2022	BACKGROUND: Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission and is activated by phosphorylation at serine 616.	Serine	128-134	dynamin 1 like	Homo sapiens	39-43
35523103-6	2022	The activation status of DRP1 in cancer cells was quantified based on the immunohistochemical stain of phosphorylated DRP1 at serine 616 (P(S616)-DRP1).	Serine	126-132	dynamin 1 like	Homo sapiens	25-29
35523103-6	2022	The activation status of DRP1 in cancer cells was quantified based on the immunohistochemical stain of phosphorylated DRP1 at serine 616 (P(S616)-DRP1).	Serine	126-132	dynamin 1 like	Homo sapiens	118-122
35611585-7	2022	MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	dynamin 1 like	Homo sapiens	81-106
35611585-7	2022	MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	dynamin 1 like	Homo sapiens	108-112
35611585-7	2022	MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	dynamin 1 like	Homo sapiens	126-130
35589683-3	2022	p53 inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling to attenuate the protein level of mitochondrial fission process 1 (MTFP1), which fosters the pro-fission dynamin-related protein 1 (Drp1) phosphorylation.	Sirolimus	37-46	dynamin 1 like	Homo sapiens	181-206
35589683-3	2022	p53 inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling to attenuate the protein level of mitochondrial fission process 1 (MTFP1), which fosters the pro-fission dynamin-related protein 1 (Drp1) phosphorylation.	Sirolimus	37-46	dynamin 1 like	Homo sapiens	208-212
35440104-5	2022	Meanwhile, flubendazole increased dynamin-related protein (DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 (PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy.	flubendazole	11-23	dynamin 1 like	Homo sapiens	59-63
35530963-10	2022	And Celastrol could regulate mitochondrial fission and fusion by promoting the phosphorylation of the Drp1 at the Ser637 site, thereby inhibiting mitochondrial fission.	celastrol	4-13	dynamin 1 like	Homo sapiens	102-106
35383983-0	2022	Blocking exosomal secretion aggravates 1,4-Benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.	quinone	39-55	dynamin 1 like	Homo sapiens	112-116
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	quinone	73-89	dynamin 1 like	Homo sapiens	379-383
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	quinone	91-97	dynamin 1 like	Homo sapiens	379-383
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Benzene	123-130	dynamin 1 like	Homo sapiens	379-383
35383983-3	2022	In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1.	Oxygen	169-175	dynamin 1 like	Homo sapiens	379-383
35530963-14	2022	Conclusions: Our study found that Celastrol could reduce inflammation by regulating Drp1 dependent mitochondrial fission and fusion, as well as the ERK1/2, p38, NF-kappaB signaling pathways.	celastrol	34-43	dynamin 1 like	Homo sapiens	84-88
35158046-7	2022	Silibinin reduced the expression of mitochondrial fission-associated proteins, dynamin-related protein 1 (DRP1), but increased mitochondrial fusion-associated proteins, optic atrophy 1 (OPA1) and mitofusin 1 (MFN1).	Silybin	0-9	dynamin 1 like	Homo sapiens	79-104
35158046-7	2022	Silibinin reduced the expression of mitochondrial fission-associated proteins, dynamin-related protein 1 (DRP1), but increased mitochondrial fusion-associated proteins, optic atrophy 1 (OPA1) and mitofusin 1 (MFN1).	Silybin	0-9	dynamin 1 like	Homo sapiens	106-110
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Ethanol	109-116	dynamin 1 like	Homo sapiens	27-31
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Acetaldehyde	121-133	dynamin 1 like	Homo sapiens	27-31
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Staurosporine	189-202	dynamin 1 like	Homo sapiens	27-31
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Staurosporine	189-202	dynamin 1 like	Homo sapiens	175-179
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Ethanol	240-247	dynamin 1 like	Homo sapiens	27-31
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Ethanol	240-247	dynamin 1 like	Homo sapiens	175-179
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Acetaldehyde	252-264	dynamin 1 like	Homo sapiens	27-31
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Acetaldehyde	252-264	dynamin 1 like	Homo sapiens	175-179
33936388-0	2021	Differential ROS-Mediated Phosphorylation of Drp1 in Mitochondrial Fragmentation Induced by Distinct Cell Death Conditions in Cerebellar Granule Neurons.	Reactive Oxygen Species	13-16	dynamin 1 like	Homo sapiens	45-49
34052344-2	2021	Dynamin-related protein 1 (Drp1) mediated mitochondrial fission is the main reason and the result of excessive ROS generation.	Reactive Oxygen Species	111-114	dynamin 1 like	Homo sapiens	0-25
34052344-2	2021	Dynamin-related protein 1 (Drp1) mediated mitochondrial fission is the main reason and the result of excessive ROS generation.	Reactive Oxygen Species	111-114	dynamin 1 like	Homo sapiens	27-31
34052344-9	2021	H2O2 induced cellular injury and inflammation, excessive ROS production, mitochondrial abnormalities, and increased expression of p-Drp1 and Drp1 in hPDLCs, which could be reversed by NAC and Mdivi-1.	Hydrogen Peroxide	0-4	dynamin 1 like	Homo sapiens	132-136
34052344-9	2021	H2O2 induced cellular injury and inflammation, excessive ROS production, mitochondrial abnormalities, and increased expression of p-Drp1 and Drp1 in hPDLCs, which could be reversed by NAC and Mdivi-1.	Hydrogen Peroxide	0-4	dynamin 1 like	Homo sapiens	141-145
34052344-9	2021	H2O2 induced cellular injury and inflammation, excessive ROS production, mitochondrial abnormalities, and increased expression of p-Drp1 and Drp1 in hPDLCs, which could be reversed by NAC and Mdivi-1.	Acetylcysteine	184-187	dynamin 1 like	Homo sapiens	132-136
34052344-9	2021	H2O2 induced cellular injury and inflammation, excessive ROS production, mitochondrial abnormalities, and increased expression of p-Drp1 and Drp1 in hPDLCs, which could be reversed by NAC and Mdivi-1.	Acetylcysteine	184-187	dynamin 1 like	Homo sapiens	141-145
33998634-5	2021	tt-DDE also induced mitochondrial fragmentation and fission by increasing DNM1L protein expression and DNM1L mitochondrial translocation.	tt-dde	0-6	dynamin 1 like	Homo sapiens	74-79
33998634-5	2021	tt-DDE also induced mitochondrial fragmentation and fission by increasing DNM1L protein expression and DNM1L mitochondrial translocation.	tt-dde	0-6	dynamin 1 like	Homo sapiens	103-108
35538029-8	2022	Confocal imaging showed that knockdown of Mff inhibits the mitochondrial fission and downregulates the expression of GTPase dynamin-related protein 1 (Drp1) in cisplatin-resistant Huh-7/DDP cells.	Cisplatin	160-169	dynamin 1 like	Homo sapiens	151-155
35368865-10	2022	Mechanistically, overexpressed Drp1 damaged mitochondria by overproduction of reactive oxygen species (ROS), which induced mitochondrial OXPHOS inhibition and decline of ATP production.	Reactive Oxygen Species	78-101	dynamin 1 like	Homo sapiens	31-35
35368865-10	2022	Mechanistically, overexpressed Drp1 damaged mitochondria by overproduction of reactive oxygen species (ROS), which induced mitochondrial OXPHOS inhibition and decline of ATP production.	Reactive Oxygen Species	103-106	dynamin 1 like	Homo sapiens	31-35
35368865-10	2022	Mechanistically, overexpressed Drp1 damaged mitochondria by overproduction of reactive oxygen species (ROS), which induced mitochondrial OXPHOS inhibition and decline of ATP production.	Adenosine Triphosphate	170-173	dynamin 1 like	Homo sapiens	31-35
35368865-13	2022	Moreover, the decreased ATP production induced by Drp1 overexpressing activated the AMPK cellular energy stress sensor and enhanced autophagy through the AMPK-ULK1 pathway, which might play a protective role in PA growth.	Adenosine Triphosphate	24-27	dynamin 1 like	Homo sapiens	50-54
35122996-6	2022	Simultaneously, sevoflurane promoted the interaction between Drp1 and GSK3beta.	Sevoflurane	16-27	dynamin 1 like	Homo sapiens	61-65
35122996-7	2022	Furthermore, GSK3beta activated phosphorylation of Drp1 at Ser616, induced mitochondrial fission, loss of mitochondrial membrane potential (MMP) and apoptosis in SK-N-SH cells, which was attenuated by TDZD-8, an inhibitor of GSK3beta.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	201-207	dynamin 1 like	Homo sapiens	51-55
35122996-8	2022	In conclusion, sevoflurane induced neurotoxicity links to a GSK3beta/Drp1 dependent mitochondrial fission and apoptosis.	Sevoflurane	15-26	dynamin 1 like	Homo sapiens	69-73
35204246-6	2022	The role of nitrosylation of Drp1 in homocysteine-mediated exacerbation of mitochondrial fragmentation was determined by supplementing incubation medium with nitric-oxide inhibitor.	Homocysteine	37-49	dynamin 1 like	Homo sapiens	29-33
35204246-7	2022	Homocysteine exacerbated glucose-induced Drp1 activation and its nitrosylation, mitochondrial fragmentation and cell apoptosis, and further decreased nucleoids and mtDNA transcription.	Homocysteine	0-12	dynamin 1 like	Homo sapiens	41-45
35204246-7	2022	Homocysteine exacerbated glucose-induced Drp1 activation and its nitrosylation, mitochondrial fragmentation and cell apoptosis, and further decreased nucleoids and mtDNA transcription.	Glucose	25-32	dynamin 1 like	Homo sapiens	41-45
35204246-8	2022	Drp1-siRNA or nitric-oxide inhibitor prevented glucose- and homocysteine-induced mitochondrial fission, damage and cell apoptosis.	Glucose	47-54	dynamin 1 like	Homo sapiens	0-4
35204246-8	2022	Drp1-siRNA or nitric-oxide inhibitor prevented glucose- and homocysteine-induced mitochondrial fission, damage and cell apoptosis.	Homocysteine	60-72	dynamin 1 like	Homo sapiens	0-4
35204246-9	2022	Thus, elevated homocysteine in a hyperglycemic environment increases Drp1 activity via increasing its nitrosylation, and this further fragments the mitochondria and increases apoptosis, ultimately leading to the development of diabetic retinopathy.	Homocysteine	15-27	dynamin 1 like	Homo sapiens	69-73
33907822-0	2021	[Retracted] Hypoxia-induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	110-114	dynamin 1 like	Homo sapiens	59-64
33705961-6	2021	Further, ceramide accumulation increased mitochondrial fission regulators such as dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF) as well as auto/mitophagic proteins LC3B and PINK-1 compared to control.	Ceramides	9-17	dynamin 1 like	Homo sapiens	82-107
33705961-6	2021	Further, ceramide accumulation increased mitochondrial fission regulators such as dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF) as well as auto/mitophagic proteins LC3B and PINK-1 compared to control.	Ceramides	9-17	dynamin 1 like	Homo sapiens	109-113
33936388-2	2021	ROS are also involved in mitochondrial fission, which is mediated by Dynamin-related protein 1 (Drp1).	Reactive Oxygen Species	0-3	dynamin 1 like	Homo sapiens	69-94
33936388-2	2021	ROS are also involved in mitochondrial fission, which is mediated by Dynamin-related protein 1 (Drp1).	Reactive Oxygen Species	0-3	dynamin 1 like	Homo sapiens	96-100
33936388-3	2021	The regulation of mitochondrial fragmentation mediated by Drp1 and its relationship to mitochondrial ROS (mtROS) in neuronal death have not been completely clarified.	Reactive Oxygen Species	101-104	dynamin 1 like	Homo sapiens	58-62
33110216-0	2021	Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury.	alr	34-37	dynamin 1 like	Homo sapiens	14-18
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	dynamin 1 like	Homo sapiens	392-417
33508714-6	2021	MC-LR exposure resulted in mitochondrial fragmentation and glucose intake decrease in granulosa cells, as shown by increasing mitochondrial fission via dynamin-related protein 1 (DRP1) upregulation and decreasing glucose transporter 1 and 4 (GLUT1 and GLUT4).	cyanoginosin LR	0-5	dynamin 1 like	Homo sapiens	152-177
33508714-6	2021	MC-LR exposure resulted in mitochondrial fragmentation and glucose intake decrease in granulosa cells, as shown by increasing mitochondrial fission via dynamin-related protein 1 (DRP1) upregulation and decreasing glucose transporter 1 and 4 (GLUT1 and GLUT4).	cyanoginosin LR	0-5	dynamin 1 like	Homo sapiens	179-183
33904649-10	2021	In conclusion, inhibiting Drp1 with short-term Mdivi-1 administration attenuates the impairment in skeletal muscle insulin signaling and improves whole-body glucose tolerance in the setting of obesity-induced insulin resistance.	Glucose	157-164	dynamin 1 like	Homo sapiens	26-30
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Caffeine	0-8	dynamin 1 like	Homo sapiens	419-423
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Cyclic AMP	67-71	dynamin 1 like	Homo sapiens	392-417
33664417-4	2021	Caffeine (50 muM) enhanced endothelial migration via activation of cAMP/PKA/AMPK signaling pathway, which was mimicked by cAMP analog 8-Br-cAMP, and blocked by PKA inhibitor H89, adenylate cyclase inhibitor SQ22536 or AMPK inhibitor compound C. Furthermore, caffeine (50 muM) induced significant mitochondrial shortening through the increased phosphorylation of mitochondrial fission protein dynamin-related protein 1 (Drp1) in HUVECs, which increased its activity to regulate mitochondrial fission.	Cyclic AMP	67-71	dynamin 1 like	Homo sapiens	419-423
33664417-5	2021	Pharmacological blockade of Drp1 by Mdivi-1 (10 muM) or disturbance of mitochondrial fission by Drp1 silencing markedly suppressed caffeine-induced lamellipodia formation and endothelial cell migration.	Caffeine	131-139	dynamin 1 like	Homo sapiens	28-32
33664417-5	2021	Pharmacological blockade of Drp1 by Mdivi-1 (10 muM) or disturbance of mitochondrial fission by Drp1 silencing markedly suppressed caffeine-induced lamellipodia formation and endothelial cell migration.	Caffeine	131-139	dynamin 1 like	Homo sapiens	96-100
33422762-0	2021	Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage.	Paraquat	64-72	dynamin 1 like	Homo sapiens	0-4
33422762-4	2021	Hence, we investigated the potential role of reactive oxygen species (ROS) and dynamin-related protein 1 (DRP1) in PQ-induced mitophagy, aiming to elaborate on possible molecular mechanisms involved in PQ-triggered neurotoxicity.	Paraquat	115-117	dynamin 1 like	Homo sapiens	79-104
33422762-4	2021	Hence, we investigated the potential role of reactive oxygen species (ROS) and dynamin-related protein 1 (DRP1) in PQ-induced mitophagy, aiming to elaborate on possible molecular mechanisms involved in PQ-triggered neurotoxicity.	Paraquat	115-117	dynamin 1 like	Homo sapiens	106-110
33422762-8	2021	Thus, our findings provide a novel neurotoxic mechanism and reveal the DRP1-mitochondrial fission pathway as a potential target for treatments of PQ-induced excessive mitophagy, serving as an alternative target for the prevention and treatment of Parkinson"s disease.	Paraquat	146-148	dynamin 1 like	Homo sapiens	71-75
33416159-0	2021	Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.	polyphyllin VII	0-15	dynamin 1 like	Homo sapiens	75-79
33523181-6	2021	A DRP1 inhibitor, mitochondrial division inhibitor 1 (mdivi-1) reduced ER localization of a DRP1 receptor, mitochondrial fission factor, suppressing ER remodeling-driven mitochondrial fission, autophagy, and increased mitochondrial calcium buffering and PCSK9 proteasomal degradation.	Calcium	232-239	dynamin 1 like	Homo sapiens	2-6
33523181-6	2021	A DRP1 inhibitor, mitochondrial division inhibitor 1 (mdivi-1) reduced ER localization of a DRP1 receptor, mitochondrial fission factor, suppressing ER remodeling-driven mitochondrial fission, autophagy, and increased mitochondrial calcium buffering and PCSK9 proteasomal degradation.	Calcium	232-239	dynamin 1 like	Homo sapiens	92-96
33152171-6	2021	Our data further revealed that DRP1 activation through serine 616 phosphorylation is regulated by ERK/AKT and CDK2 in lung adenocarcinoma cell lines.	Serine	55-61	dynamin 1 like	Homo sapiens	31-35
33603830-5	2021	The results revealed that glutamate treatment led to large increases in the mitochondrial levels of the major fission proteins dynamin-related protein 1 (Drp1) and mitochondrial fission 1 protein (Fis1), but only small elevations in the fusion proteins mitofusin 1 and 2 (Mfn1/2) and optic atrophy 1 (Opa1).	Glutamic Acid	26-35	dynamin 1 like	Homo sapiens	127-152
33603830-5	2021	The results revealed that glutamate treatment led to large increases in the mitochondrial levels of the major fission proteins dynamin-related protein 1 (Drp1) and mitochondrial fission 1 protein (Fis1), but only small elevations in the fusion proteins mitofusin 1 and 2 (Mfn1/2) and optic atrophy 1 (Opa1).	Glutamic Acid	26-35	dynamin 1 like	Homo sapiens	154-158
33603830-7	2021	Pretreatment with B35525 reduced glutamate-induced cell death and prevented the increases in the protein levels of Drp1, Fis1, Mfn1/2 and Opa1 in the mitochondrial fraction.	b35525	18-24	dynamin 1 like	Homo sapiens	115-119
33416159-9	2021	In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity.	polyphyllin VII	13-28	dynamin 1 like	Homo sapiens	72-76
33452331-11	2021	Subsequent, upregulated expression of Drp1 and BAX proteins by 2-ME strongly suggests the activation of the intrinsic apoptosis pathway.	2-Methoxyestradiol	63-67	dynamin 1 like	Homo sapiens	38-42
33302576-0	2020	Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression.	Cisplatin	46-55	dynamin 1 like	Homo sapiens	14-18
33436835-5	2021	OmpAAb mediated activation of DRP1 enhances its accumulation on mitochondria that causes mitochondrial fragmentation, elevation in reactive oxygen species (ROS) production and cell death.	Reactive Oxygen Species	131-154	dynamin 1 like	Homo sapiens	30-34
33436835-5	2021	OmpAAb mediated activation of DRP1 enhances its accumulation on mitochondria that causes mitochondrial fragmentation, elevation in reactive oxygen species (ROS) production and cell death.	Reactive Oxygen Species	156-159	dynamin 1 like	Homo sapiens	30-34
32961495-7	2020	Cr(VI) induced reactive oxygen species (ROS) overproduction, led to dynamin-related protein 1 (Drp1) translocation to mitochondria and the subsequent mitochondrial fission, contributing to the caspase-3-dependent mitochondrial apoptosis as evidenced by higher mitochondrial permeability transition pore (mPTP) opening rate, lower mitochondrial membrane potential (MMP), and more alanine transaminase (ALT)/aspartate transaminase (AST) leakage into the culture medium.	Reactive Oxygen Species	40-43	dynamin 1 like	Homo sapiens	68-93
32961495-10	2020	All in all, the present study demonstrated that Cr(VI) induced hepatocytes apoptosis via Ca2+-ROS-Drp1-mitochondrial fission axis and CLU alleviated the mitochondrial apoptosis through activation of the AMPK/SERCA2a pathway.	chromium hexavalent ion	48-54	dynamin 1 like	Homo sapiens	98-102
33106070-8	2020	In addition, DHA decreased protein expression of TNF receptor, receptor interacting protein kinase 1, RIP3 and phosphorylation of mixed lineage kinase-like protein, phosphoglycerate mutase family 5, dynamin-related protein 1 and high mobility group box-1 protein.	Docosahexaenoic Acids	13-16	dynamin 1 like	Homo sapiens	199-224
32961495-0	2020	Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca2+-ROS-Drp1-mitochondrial fission axis.	chromium hexavalent ion	21-27	dynamin 1 like	Homo sapiens	106-110
32961495-0	2020	Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca2+-ROS-Drp1-mitochondrial fission axis.	Reactive Oxygen Species	102-105	dynamin 1 like	Homo sapiens	106-110
32961495-7	2020	Cr(VI) induced reactive oxygen species (ROS) overproduction, led to dynamin-related protein 1 (Drp1) translocation to mitochondria and the subsequent mitochondrial fission, contributing to the caspase-3-dependent mitochondrial apoptosis as evidenced by higher mitochondrial permeability transition pore (mPTP) opening rate, lower mitochondrial membrane potential (MMP), and more alanine transaminase (ALT)/aspartate transaminase (AST) leakage into the culture medium.	Chromium	0-2	dynamin 1 like	Homo sapiens	68-93
32961495-7	2020	Cr(VI) induced reactive oxygen species (ROS) overproduction, led to dynamin-related protein 1 (Drp1) translocation to mitochondria and the subsequent mitochondrial fission, contributing to the caspase-3-dependent mitochondrial apoptosis as evidenced by higher mitochondrial permeability transition pore (mPTP) opening rate, lower mitochondrial membrane potential (MMP), and more alanine transaminase (ALT)/aspartate transaminase (AST) leakage into the culture medium.	Chromium	0-2	dynamin 1 like	Homo sapiens	95-99
33219495-1	2021	PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC).	Serine	114-120	dynamin 1 like	Homo sapiens	9-34
33219495-1	2021	PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC).	Serine	114-120	dynamin 1 like	Homo sapiens	36-40
33219495-1	2021	PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC).	Serine	114-120	dynamin 1 like	Homo sapiens	133-137
33219495-2	2021	In this study, the expression of DRP1 and S616-p-DRP1 and its relationship with patients" clinicopathological characteristics, tumor genetic profiles, and clinical outcomes were assessed in a large series of follicular cell-derived TC (FCDTC).	fcdtc	236-241	dynamin 1 like	Homo sapiens	33-37
32767829-0	2020	DRP1 promotes lactate utilization in KRAS-mutant non-small cell lung cancer cells.	Lactic Acid	14-21	dynamin 1 like	Homo sapiens	0-4
33194600-11	2020	The DVLP regimen (n=23) is the most common peg-asp regimen used in AAP patients.	pegaspargase	43-50	dynamin 1 like	Homo sapiens	4-8
33194600-11	2020	The DVLP regimen (n=23) is the most common peg-asp regimen used in AAP patients.	aap	67-70	dynamin 1 like	Homo sapiens	4-8
32888618-0	2020	Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.	chromium hexavalent ion	52-58	dynamin 1 like	Homo sapiens	0-4
32888618-2	2020	Role of dynamin-related protein 1 (Drp1) and Drp1-associated mitochondrial fragmentation in mitophagy and cytotoxicity after Cr(VI) exposure has not been clarified so far.	chromium hexavalent ion	125-131	dynamin 1 like	Homo sapiens	8-33
32888618-2	2020	Role of dynamin-related protein 1 (Drp1) and Drp1-associated mitochondrial fragmentation in mitophagy and cytotoxicity after Cr(VI) exposure has not been clarified so far.	chromium hexavalent ion	125-131	dynamin 1 like	Homo sapiens	45-49
32888618-3	2020	We confirmed that Cr(VI) caused mitochondrial fission by up-regulating Drp1 expression and enhancing Drp1 mitochondrial translocation.	chromium hexavalent ion	18-24	dynamin 1 like	Homo sapiens	71-75
32888618-3	2020	We confirmed that Cr(VI) caused mitochondrial fission by up-regulating Drp1 expression and enhancing Drp1 mitochondrial translocation.	chromium hexavalent ion	18-24	dynamin 1 like	Homo sapiens	101-105
32888618-4	2020	By applying the intracellular Ca2+ antagonist BAPTA-AM and mitochondrial Ca2+ antagonist Ru360, we demonstrated that Cr(VI)-induced excessive mitochondrial fission was in a Ca2+-Drp1 dependent manner.	Ru 360	89-94	dynamin 1 like	Homo sapiens	178-182
32888618-4	2020	By applying the intracellular Ca2+ antagonist BAPTA-AM and mitochondrial Ca2+ antagonist Ru360, we demonstrated that Cr(VI)-induced excessive mitochondrial fission was in a Ca2+-Drp1 dependent manner.	chromium hexavalent ion	117-123	dynamin 1 like	Homo sapiens	178-182
32888618-5	2020	The administration of Drp1 siRNA significantly suppressed the overactivation of mitophagy in Cr(VI)-induced hepatotoxicity.	chromium hexavalent ion	93-99	dynamin 1 like	Homo sapiens	22-26
32888618-6	2020	The specific Drp1 inhibitor mitochondrial division inhibitor-1 (Mdivi-1) blocked the overactive mitophagy and subsequently ameliorated hepatotoxicity caused by Cr(VI) in vivo.	chromium hexavalent ion	160-166	dynamin 1 like	Homo sapiens	13-17
32888618-7	2020	We reached the conclusion that Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity, which may provide experimental basis for the study of chromium-associated toxicity, especially for the prevention of health damage in chromium-exposed population.	chromium hexavalent ion	83-89	dynamin 1 like	Homo sapiens	31-35
32888618-7	2020	We reached the conclusion that Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity, which may provide experimental basis for the study of chromium-associated toxicity, especially for the prevention of health damage in chromium-exposed population.	Chromium	182-190	dynamin 1 like	Homo sapiens	31-35
32888618-7	2020	We reached the conclusion that Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity, which may provide experimental basis for the study of chromium-associated toxicity, especially for the prevention of health damage in chromium-exposed population.	Chromium	262-270	dynamin 1 like	Homo sapiens	31-35
33044904-7	2021	In a series of gain-of-function and loss-of-function experiments in rodent and human myotubes, we demonstrate that BNIP3L accumulation triggers mitochondrial depolarization, calcium-dependent activation of DNM1L/DRP1, and mitophagy.	Calcium	174-181	dynamin 1 like	Homo sapiens	206-211
33044904-7	2021	In a series of gain-of-function and loss-of-function experiments in rodent and human myotubes, we demonstrate that BNIP3L accumulation triggers mitochondrial depolarization, calcium-dependent activation of DNM1L/DRP1, and mitophagy.	Calcium	174-181	dynamin 1 like	Homo sapiens	212-216
32108342-0	2020	AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes.	Glucose	20-27	dynamin 1 like	Homo sapiens	89-93
32666227-0	2020	CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP.	mangion-purified polysaccharide (Candida albicans)	145-148	dynamin 1 like	Homo sapiens	80-84
32666227-8	2020	Treatment with hypothermia, or a selective CDK4 inhibitor, or roscovitine (CDK5 inhibitor) prevented MPP+-induced mitochondrial fission, upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1), and neuron death.	Roscovitine	62-73	dynamin 1 like	Homo sapiens	183-208
32666227-8	2020	Treatment with hypothermia, or a selective CDK4 inhibitor, or roscovitine (CDK5 inhibitor) prevented MPP+-induced mitochondrial fission, upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1), and neuron death.	Roscovitine	62-73	dynamin 1 like	Homo sapiens	210-214
32666227-8	2020	Treatment with hypothermia, or a selective CDK4 inhibitor, or roscovitine (CDK5 inhibitor) prevented MPP+-induced mitochondrial fission, upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1), and neuron death.	mangion-purified polysaccharide (Candida albicans)	101-105	dynamin 1 like	Homo sapiens	183-208
32666227-8	2020	Treatment with hypothermia, or a selective CDK4 inhibitor, or roscovitine (CDK5 inhibitor) prevented MPP+-induced mitochondrial fission, upregulation of mitochondrial fission protein dynamin-related protein 1 (Drp1), and neuron death.	mangion-purified polysaccharide (Candida albicans)	101-105	dynamin 1 like	Homo sapiens	210-214
32666227-9	2020	In addition, overexpression of dominant negative mutant Drp1K38A improved MPP+-induced mitochondrial fission while overexpression of wild-type Drp1 blunted the prevention of mitochondrial fission by hypothermia as well as CDK4 inhibitor and roscovitine.	mangion-purified polysaccharide (Candida albicans)	74-78	dynamin 1 like	Homo sapiens	56-60
32666227-9	2020	In addition, overexpression of dominant negative mutant Drp1K38A improved MPP+-induced mitochondrial fission while overexpression of wild-type Drp1 blunted the prevention of mitochondrial fission by hypothermia as well as CDK4 inhibitor and roscovitine.	Roscovitine	241-252	dynamin 1 like	Homo sapiens	56-60
32666227-10	2020	These results elucidate that hypothermia may inhibit CDK4 and CDK5 activation by upregulating p27 and p35 expression to prevent Drp1-dependent mitochondrial fission and neuron loss after MPP+ treatment.	mangion-purified polysaccharide (Candida albicans)	187-191	dynamin 1 like	Homo sapiens	128-132
32910998-0	2020	Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.	3-chlorpropane-1,2-diol	90-113	dynamin 1 like	Homo sapiens	0-4
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	alpha-Chlorohydrin	145-151	dynamin 1 like	Homo sapiens	36-61
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	alpha-Chlorohydrin	145-151	dynamin 1 like	Homo sapiens	63-67
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	Adenosine Triphosphate	265-268	dynamin 1 like	Homo sapiens	36-61
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	Adenosine Triphosphate	265-268	dynamin 1 like	Homo sapiens	63-67
33126676-2	2020	It is known that the constriction step is mediated by a GTPase named dynamin-like protein 1 (DLP1) upon efficient loading of GTP.	Guanosine Triphosphate	56-59	dynamin 1 like	Homo sapiens	69-91
33126676-2	2020	It is known that the constriction step is mediated by a GTPase named dynamin-like protein 1 (DLP1) upon efficient loading of GTP.	Guanosine Triphosphate	56-59	dynamin 1 like	Homo sapiens	93-97
33126676-3	2020	However, mechanism of fuelling GTP to DLP1 remains unknown in mammals.	Guanosine Triphosphate	31-34	dynamin 1 like	Homo sapiens	38-42
33126676-4	2020	We earlier show that nucleoside diphosphate (NDP) kinase-like protein, termed dynamin-based ring motive-force organizer 1 (DYNAMO1), generates GTP for DLP1 in a red alga, Cyanidioschyzon merolae.	Guanosine Triphosphate	143-146	dynamin 1 like	Homo sapiens	151-155
32777260-0	2020	Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.	Luteolin	0-8	dynamin 1 like	Homo sapiens	110-114
32777260-8	2020	Moreover, luteolin treatment alone or in combination with TRAIL increased the phosphorylation of c-Jun N-terminal kinase (JNK), while SP600125 (the JNK inhibitor) significantly abolished the synergistic effect on DR5 expression and Drp1 translocation, indicating that JNK signaling activation was greatly associated with the synergistic effect exerted by luteolin in NSCLC cells.	Luteolin	10-18	dynamin 1 like	Homo sapiens	232-236
32777260-8	2020	Moreover, luteolin treatment alone or in combination with TRAIL increased the phosphorylation of c-Jun N-terminal kinase (JNK), while SP600125 (the JNK inhibitor) significantly abolished the synergistic effect on DR5 expression and Drp1 translocation, indicating that JNK signaling activation was greatly associated with the synergistic effect exerted by luteolin in NSCLC cells.	pyrazolanthrone	134-142	dynamin 1 like	Homo sapiens	232-236
32767829-6	2020	Moreover, targeting DRP1 not only reduces HSP90 expression but also enhances ROS-induced HSP90 cleavage, thus inhibiting activation of the MAPK and PI3K pathways and leading to suppressed lactate utilization and increased ROS-induced cell death.	Lactic Acid	188-195	dynamin 1 like	Homo sapiens	20-24
32767829-6	2020	Moreover, targeting DRP1 not only reduces HSP90 expression but also enhances ROS-induced HSP90 cleavage, thus inhibiting activation of the MAPK and PI3K pathways and leading to suppressed lactate utilization and increased ROS-induced cell death.	Reactive Oxygen Species	222-225	dynamin 1 like	Homo sapiens	20-24
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	74-81	dynamin 1 like	Homo sapiens	43-47
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	157-164	dynamin 1 like	Homo sapiens	43-47
32767829-7	2020	Taken together, these results suggest that DRP1 is a crucial regulator of lactate metabolism and redox homeostasis in KRAS-mutant lung cancer, and targeting lactate utilization by modulating DRP1 activity might be an effective treatment for lung cancer.	Lactic Acid	157-164	dynamin 1 like	Homo sapiens	191-195
32696439-4	2020	Dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation leads to excess ROS generation, which is implicated in the pathogenesis of neuropathic pain.	ros	86-89	dynamin 1 like	Homo sapiens	0-25
32696439-4	2020	Dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation leads to excess ROS generation, which is implicated in the pathogenesis of neuropathic pain.	ros	86-89	dynamin 1 like	Homo sapiens	27-31
32696439-8	2020	We summarized a Drp1-mitochondrial fission-ROS cycle that potentially functions in neuropathic pain and is regulated by posttranslational modifications and Ca2+.	ros	43-46	dynamin 1 like	Homo sapiens	16-20
32883957-6	2020	Both the pharmacological inhibition of Cdk5 by roscovitine and the inhibition of Drp1 by mdivi-1 inhibited mitochondrial fission and the production of ROS associated with radiation-induced neuronal loss.	Reactive Oxygen Species	151-154	dynamin 1 like	Homo sapiens	81-85
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	15-22	dynamin 1 like	Homo sapiens	98-102
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	15-22	dynamin 1 like	Homo sapiens	257-261
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	205-212	dynamin 1 like	Homo sapiens	98-102
32767829-3	2020	We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.	Lactic Acid	205-212	dynamin 1 like	Homo sapiens	257-261
32767829-4	2020	Metabolic and transcriptional profiling suggests that DRP1 orchestrates a supportive metabolic network to promote lactate utilization and redox homeostasis in lung cancer cells.	Lactic Acid	114-121	dynamin 1 like	Homo sapiens	54-58
32767829-5	2020	DRP1 suppresses the production of reactive oxygen species (ROS) and protects cells against oxidative damage by enhancing lactate utilization.	Reactive Oxygen Species	34-57	dynamin 1 like	Homo sapiens	0-4
32767829-5	2020	DRP1 suppresses the production of reactive oxygen species (ROS) and protects cells against oxidative damage by enhancing lactate utilization.	Reactive Oxygen Species	59-62	dynamin 1 like	Homo sapiens	0-4
32767829-5	2020	DRP1 suppresses the production of reactive oxygen species (ROS) and protects cells against oxidative damage by enhancing lactate utilization.	Lactic Acid	121-128	dynamin 1 like	Homo sapiens	0-4
32767829-6	2020	Moreover, targeting DRP1 not only reduces HSP90 expression but also enhances ROS-induced HSP90 cleavage, thus inhibiting activation of the MAPK and PI3K pathways and leading to suppressed lactate utilization and increased ROS-induced cell death.	Reactive Oxygen Species	77-80	dynamin 1 like	Homo sapiens	20-24
32751088-0	2020	Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity.	Chromium	102-110	dynamin 1 like	Homo sapiens	50-75
32060978-11	2020	In summary, our results provide evidence of Drp1-mediated mitochondrial fission during activation of ionotropic glutamate receptors in oligodendrocytes, and uncover a deleterious and Drp1-independent effect of mdivi-1 on mitochondrial and ER function in these cells.	Glutamic Acid	112-121	dynamin 1 like	Homo sapiens	44-48
32787872-11	2020	Ethanol-increased NMDAR induced intracellular calcium overload and calmodulin-dependent protein kinase II (CaMKII) activation leading to phosphorylation of dynamin-related protein 1 (Drp1) and c-Jun N-terminal protein kinase 1 (JNK1).	Ethanol	0-7	dynamin 1 like	Homo sapiens	156-181
32787872-11	2020	Ethanol-increased NMDAR induced intracellular calcium overload and calmodulin-dependent protein kinase II (CaMKII) activation leading to phosphorylation of dynamin-related protein 1 (Drp1) and c-Jun N-terminal protein kinase 1 (JNK1).	Ethanol	0-7	dynamin 1 like	Homo sapiens	183-187
32787872-12	2020	Drp1 phosphorylation promoted Drp1 translocation to the mitochondria, resulting in excessive mitochondrial fission, mitochondrial ROS accumulation, and loss of mitochondrial membrane potential, which was recovered by Drp1 inhibitor pretreatment.	Reactive Oxygen Species	130-133	dynamin 1 like	Homo sapiens	0-4
32787872-12	2020	Drp1 phosphorylation promoted Drp1 translocation to the mitochondria, resulting in excessive mitochondrial fission, mitochondrial ROS accumulation, and loss of mitochondrial membrane potential, which was recovered by Drp1 inhibitor pretreatment.	Reactive Oxygen Species	130-133	dynamin 1 like	Homo sapiens	30-34
32787872-12	2020	Drp1 phosphorylation promoted Drp1 translocation to the mitochondria, resulting in excessive mitochondrial fission, mitochondrial ROS accumulation, and loss of mitochondrial membrane potential, which was recovered by Drp1 inhibitor pretreatment.	Reactive Oxygen Species	130-133	dynamin 1 like	Homo sapiens	30-34
32787872-15	2020	CONCLUSIONS: Our results demonstrated that ethanol upregulated NMDAR-dependent CaMKII phosphorylation which is essential for Drp1-mediated excessive mitochondrial fission and the JNK1-induced NLRP3 inflammasome activation resulting in neuronal apoptosis.	Ethanol	43-50	dynamin 1 like	Homo sapiens	125-129
32751702-9	2020	Here, we review the current understanding of Dnm1/Drp1-mediated divisions of mitochondria and peroxisomes, exploring the mechanisms of GTP regulation during the Dnm1/Drp1 function, and provide new perspectives on their potential contribution to mitochondrial and peroxisomal biogenesis.	Guanosine Triphosphate	135-138	dynamin 1 like	Homo sapiens	50-54
32751702-9	2020	Here, we review the current understanding of Dnm1/Drp1-mediated divisions of mitochondria and peroxisomes, exploring the mechanisms of GTP regulation during the Dnm1/Drp1 function, and provide new perspectives on their potential contribution to mitochondrial and peroxisomal biogenesis.	Guanosine Triphosphate	135-138	dynamin 1 like	Homo sapiens	166-170
32969792-9	2020	In HaCaT cells, Drp1 transfection altered cellular ATP and proliferation, induced G2/M arrest, and affected inflammatory mediator (TNF-alpha, IL-6 and CXCL8) release.	Adenosine Triphosphate	51-54	dynamin 1 like	Homo sapiens	16-20
32751088-7	2020	The cytotoxicity in the Drp1-si plus Cr(VI) treatment group was alleviated by the application of Glu/Mal, and was aggravated by the application of ROT.	Glutamic Acid	97-100	dynamin 1 like	Homo sapiens	24-28
32751088-8	2020	Drp1 siRNA promoted the inhibition of Glu/Mal on Cr(VI)-induced cytotoxicity, and alleviated the aggravation of ROT on Cr(VI)-induced cytotoxicity.	Glutamic Acid	38-41	dynamin 1 like	Homo sapiens	0-4
32751088-8	2020	Drp1 siRNA promoted the inhibition of Glu/Mal on Cr(VI)-induced cytotoxicity, and alleviated the aggravation of ROT on Cr(VI)-induced cytotoxicity.	chromium hexavalent ion	49-55	dynamin 1 like	Homo sapiens	0-4
32751088-8	2020	Drp1 siRNA promoted the inhibition of Glu/Mal on Cr(VI)-induced cytotoxicity, and alleviated the aggravation of ROT on Cr(VI)-induced cytotoxicity.	chromium hexavalent ion	119-125	dynamin 1 like	Homo sapiens	0-4
32751088-9	2020	Taken together, Cr(VI)-induced Drp1 modulation was dependent on MRCC I inhibition-mediated ROS production, and Drp1-mediated mitochondrial fragmentation contributed to Cr(VI)-induced MRCC I-dependent cytotoxicity, which provided the experimental basis for further elucidating Cr(VI)-induced cytotoxicity.	chromium hexavalent ion	16-22	dynamin 1 like	Homo sapiens	31-35
32751088-9	2020	Taken together, Cr(VI)-induced Drp1 modulation was dependent on MRCC I inhibition-mediated ROS production, and Drp1-mediated mitochondrial fragmentation contributed to Cr(VI)-induced MRCC I-dependent cytotoxicity, which provided the experimental basis for further elucidating Cr(VI)-induced cytotoxicity.	Reactive Oxygen Species	91-94	dynamin 1 like	Homo sapiens	31-35
32751088-9	2020	Taken together, Cr(VI)-induced Drp1 modulation was dependent on MRCC I inhibition-mediated ROS production, and Drp1-mediated mitochondrial fragmentation contributed to Cr(VI)-induced MRCC I-dependent cytotoxicity, which provided the experimental basis for further elucidating Cr(VI)-induced cytotoxicity.	chromium hexavalent ion	168-174	dynamin 1 like	Homo sapiens	111-115
32751088-9	2020	Taken together, Cr(VI)-induced Drp1 modulation was dependent on MRCC I inhibition-mediated ROS production, and Drp1-mediated mitochondrial fragmentation contributed to Cr(VI)-induced MRCC I-dependent cytotoxicity, which provided the experimental basis for further elucidating Cr(VI)-induced cytotoxicity.	chromium hexavalent ion	168-174	dynamin 1 like	Homo sapiens	111-115
32751088-6	2020	Cr(VI) induced excessive mitochondrial fragmentation and mitochondrial dynamin-related protein 1 (Drp1) translocation, the application of Drp1-siRNA alleviated Cr(VI)-induced apoptosis.	Chromium	0-2	dynamin 1 like	Homo sapiens	71-96
32751088-6	2020	Cr(VI) induced excessive mitochondrial fragmentation and mitochondrial dynamin-related protein 1 (Drp1) translocation, the application of Drp1-siRNA alleviated Cr(VI)-induced apoptosis.	Chromium	0-2	dynamin 1 like	Homo sapiens	98-102
32751088-6	2020	Cr(VI) induced excessive mitochondrial fragmentation and mitochondrial dynamin-related protein 1 (Drp1) translocation, the application of Drp1-siRNA alleviated Cr(VI)-induced apoptosis.	Chromium	0-2	dynamin 1 like	Homo sapiens	138-142
32751088-6	2020	Cr(VI) induced excessive mitochondrial fragmentation and mitochondrial dynamin-related protein 1 (Drp1) translocation, the application of Drp1-siRNA alleviated Cr(VI)-induced apoptosis.	chromium hexavalent ion	0-6	dynamin 1 like	Homo sapiens	71-96
32751088-6	2020	Cr(VI) induced excessive mitochondrial fragmentation and mitochondrial dynamin-related protein 1 (Drp1) translocation, the application of Drp1-siRNA alleviated Cr(VI)-induced apoptosis.	chromium hexavalent ion	0-6	dynamin 1 like	Homo sapiens	98-102
31887787-0	2020	MicroRNA26a inhibits cisplatin-induced renal tubular epithelial cells apoptosis through suppressing the expression of transient receptor potential channel 6 mediated dynamin-related protein 1.	Cisplatin	21-30	dynamin 1 like	Homo sapiens	166-191
32661251-13	2020	In conclusion, our results demonstrate that blocking DRP1-mediated mitochondrial fission and mitophagy increases the incidence of mitochondrial apoptosis of HCC cells during hypoxia, suggesting the new approach of targeting mitophagy to potentiate TAE/TACE.	tae	248-251	dynamin 1 like	Homo sapiens	53-57
31887787-14	2020	We further verified that miR-26a protected cisplatin-induced apoptosis by target transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamic-related protein 1 (DRP1) and inhibit the mitochondrial apoptosis pathway.	Cisplatin	43-52	dynamin 1 like	Homo sapiens	165-190
31887787-14	2020	We further verified that miR-26a protected cisplatin-induced apoptosis by target transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamic-related protein 1 (DRP1) and inhibit the mitochondrial apoptosis pathway.	Cisplatin	43-52	dynamin 1 like	Homo sapiens	192-196
31887787-15	2020	Thus, miR-26a/TRPC6/DRP1 is a new protective pathway in cisplatin-induced AKI and may be targeted for the prevention and treatment of drug-related acute kidney injury.	Cisplatin	56-65	dynamin 1 like	Homo sapiens	20-24
31887787-10	2020	We further verified that miR-26a protected against cisplatin-induced cell apoptosis by acting on transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamin-related protein 1 (DRP1), thus inhibited the mitochondrial apoptosis pathway.	Cisplatin	51-60	dynamin 1 like	Homo sapiens	181-206
31887787-10	2020	We further verified that miR-26a protected against cisplatin-induced cell apoptosis by acting on transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamin-related protein 1 (DRP1), thus inhibited the mitochondrial apoptosis pathway.	Cisplatin	51-60	dynamin 1 like	Homo sapiens	208-212
31887787-11	2020	Therefore, the study unveiled that miR-26a/TRPC6/DRP1 is a novel protective pathway in cisplatin-induced AKI and may be targeted for the prevention and treatment of drug-related renal injury.	Cisplatin	87-96	dynamin 1 like	Homo sapiens	49-53
32351292-3	2020	PTEN-induced putative kinase 1 (PINK1) and phosphorylation of dynamin-related protein 1 (DRP1) are critical regulators of ROS and apoptosis.	Reactive Oxygen Species	122-125	dynamin 1 like	Homo sapiens	62-87
32368857-0	2020	Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway.	Melatonin	0-9	dynamin 1 like	Homo sapiens	91-95
32368857-2	2020	Melatonin has previously been shown to protect against cardiovascular disease, so this study sought to explore whether it attenuates vascular calcification by regulating mitochondrial fission via the AMP-activated protein kinase/dynamin-related protein 1 (AMPK/Drp1) signalling pathway.	Melatonin	0-9	dynamin 1 like	Homo sapiens	261-265
32368857-7	2020	Runx2 and cleaved caspase 3 were down-regulated, Drp1 was reduced in response to melatonin, and this was accompanied by decreased apoptosis.	Melatonin	81-90	dynamin 1 like	Homo sapiens	49-53
32368857-10	2020	Melatonin significantly activated the expression of AMPK and decreased Drp1 expression.	Melatonin	0-9	dynamin 1 like	Homo sapiens	71-75
32368857-12	2020	These findings indicate that melatonin protects VSMCs against calcification by inhibiting mitochondrial fission via the AMPK/Drp1 pathway.	Melatonin	29-38	dynamin 1 like	Homo sapiens	125-129
32304005-9	2020	Besides, high glucose also caused a shift in mitochondrial dynamics towards the appearance of more fused and lesser fragmented mitochondria, with a concomitant decrease in the expression of DRP1, suggesting decreased mitochondrial biogenesis.	Glucose	14-21	dynamin 1 like	Homo sapiens	190-194
32014401-6	2020	As expected, mdivi-1 or siRNA targeting DRP1 reversed silibinin-induced mitochondrial fission due to down-regulation in the expression of DRP1.	Silybin	54-63	dynamin 1 like	Homo sapiens	40-44
32014401-6	2020	As expected, mdivi-1 or siRNA targeting DRP1 reversed silibinin-induced mitochondrial fission due to down-regulation in the expression of DRP1.	Silybin	54-63	dynamin 1 like	Homo sapiens	138-142
32433544-0	2020	Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance.	Cisplatin	86-95	dynamin 1 like	Homo sapiens	0-4
32433544-10	2020	In addition, EBV-LMP1 regulates Drp1 through two oncogenic signaling axes, AMPK and cyclin B1/Cdk1, which promote cell survival and cisplatin resistance in NPC.	Cisplatin	132-141	dynamin 1 like	Homo sapiens	32-36
32433544-11	2020	Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.	Serine	128-134	dynamin 1 like	Homo sapiens	104-108
32184231-0	2020	Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing.	Calcium	46-53	dynamin 1 like	Homo sapiens	0-4
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	Calcium	174-181	dynamin 1 like	Homo sapiens	85-110
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	Calcium	174-181	dynamin 1 like	Homo sapiens	112-116
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	ros	217-220	dynamin 1 like	Homo sapiens	85-110
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	ros	217-220	dynamin 1 like	Homo sapiens	112-116
32351292-3	2020	PTEN-induced putative kinase 1 (PINK1) and phosphorylation of dynamin-related protein 1 (DRP1) are critical regulators of ROS and apoptosis.	Reactive Oxygen Species	122-125	dynamin 1 like	Homo sapiens	89-93
32147668-1	2020	BACKGROUND: Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation through inducing mitochondrial fusion and altering oxygen consumption.	Oxygen	231-237	dynamin 1 like	Homo sapiens	137-141
32312970-0	2020	Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways.	Glutathione	112-115	dynamin 1 like	Homo sapiens	0-4
32312970-6	2020	Furthermore, Drp1 mediated metabolic disorders and inhibited the levels of mitochondrial glutathione to impair free radical scavenging, leading to further increases in ROS and the exacerbation of mitochondrial dysfunction after ischemic injury.	Glutathione	89-100	dynamin 1 like	Homo sapiens	13-17
32312970-6	2020	Furthermore, Drp1 mediated metabolic disorders and inhibited the levels of mitochondrial glutathione to impair free radical scavenging, leading to further increases in ROS and the exacerbation of mitochondrial dysfunction after ischemic injury.	ros	168-171	dynamin 1 like	Homo sapiens	13-17
32020641-8	2020	The translocation of Drp1 to the mitochondria was also induced in patients with severe ALD and was affected in the PCLS with short-term exposure to ethanol but only mildly.	Ethanol	148-155	dynamin 1 like	Homo sapiens	21-25
32017930-0	2020	Drp1 mediates high glucose-induced mitochondrial dysfunction and epithelial-mesenchymal transition in endometrial cancer cells.	Glucose	19-26	dynamin 1 like	Homo sapiens	0-4
32017930-1	2020	This study aims to clarify the role and molecular mechanism of dynamin-related protein 1 (Drp1)-mediated mitochondrial homeostasis in high glucose (HG)-induced endometrial cancer (EC).	Glucose	139-146	dynamin 1 like	Homo sapiens	63-88
32017930-1	2020	This study aims to clarify the role and molecular mechanism of dynamin-related protein 1 (Drp1)-mediated mitochondrial homeostasis in high glucose (HG)-induced endometrial cancer (EC).	Glucose	139-146	dynamin 1 like	Homo sapiens	90-94
32576130-9	2020	The addition of shikonin inhibited DRP1 expression and increased drug uptake.	shikonin	16-24	dynamin 1 like	Homo sapiens	35-39
32226384-0	2020	Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer.	Silybin	0-9	dynamin 1 like	Homo sapiens	55-59
31873747-5	2020	We further found that respiratory activity, as measured by oxygen consumption rates, was severely repressed in Drp1-deficient HeLa cells and that this was reversible by the co-repression of mitochondrial fusion factors.	Oxygen	59-65	dynamin 1 like	Homo sapiens	111-115
32020220-6	2020	Accordingly, cisplatin induced mitophagy in surviving HCC cells by activating DRP1.	Cisplatin	13-22	dynamin 1 like	Homo sapiens	78-82
32020220-7	2020	The DRP1 inhibitor (Mdivi-1) increased the apoptosis of cisplatin-treated HCC cells by targeting mitophagy.	Cisplatin	56-65	dynamin 1 like	Homo sapiens	4-8
32020220-10	2020	Our results indicate that targeting cisplatin-mediated mitophagy increases HCC apoptosis via DRP1 inhibition, providing preclinical proof of concept for combination therapy targeting mitophagy to potentiate the efficacy of chemotherapy.	Cisplatin	36-45	dynamin 1 like	Homo sapiens	93-97
32111722-0	2020	Correction: Dynamin-related protein 1 inhibition mitigates bisphenol A-mediated alterations in mitochondrial dynamics and neural stem cell proliferation and differentiation.	bisphenol A	59-70	dynamin 1 like	Homo sapiens	12-37
32193326-4	2020	Here, we found that microdomains of phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi network (TGN) vesicles were recruited to mitochondria-ER contact sites and could drive mitochondrial division downstream of Drp1.	phosphatidylinositol 4-phosphate	36-68	dynamin 1 like	Homo sapiens	217-221
32193326-4	2020	Here, we found that microdomains of phosphatidylinositol 4-phosphate [PI(4)P] on trans-Golgi network (TGN) vesicles were recruited to mitochondria-ER contact sites and could drive mitochondrial division downstream of Drp1.	pi(4)p	70-76	dynamin 1 like	Homo sapiens	217-221
32226384-5	2020	Here, we showed that SB markedly suppressed cervical cell proliferation by inducing G2/M cell cycle arrest via the activation of dynamin-related protein 1 (Drp1), which in turn mediated the mitochondrial fission dysfunction both in vitro and in vivo.	Silybin	21-23	dynamin 1 like	Homo sapiens	129-154
32226384-5	2020	Here, we showed that SB markedly suppressed cervical cell proliferation by inducing G2/M cell cycle arrest via the activation of dynamin-related protein 1 (Drp1), which in turn mediated the mitochondrial fission dysfunction both in vitro and in vivo.	Silybin	21-23	dynamin 1 like	Homo sapiens	156-160
32226384-8	2020	Further study showed that knockdown of Drp1 abolished the SB-induced G2/M cell cycle arrest in cervical cancer cells by inhibiting the mitochondrial fission pathway.	Silybin	58-60	dynamin 1 like	Homo sapiens	39-43
32226384-10	2020	In conclusion, we are the first to demonstrate that SB induces cervical cancer cell G2/M cell cycle arrest by activating Drp1-dependent mitochondrial fission dysfunction.	Silybin	52-54	dynamin 1 like	Homo sapiens	121-125
31994339-0	2020	Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.	Copper	30-40	dynamin 1 like	Homo sapiens	101-105
31994339-8	2020	Our findings established a previously unrecognized role for copper complex in aerobic glycolysis of tumour cells, revealing the interaction between mitochondrial HK2-mediated mitophagy and Drp1-regulated mitochondrial fission.	Copper	60-66	dynamin 1 like	Homo sapiens	189-193
31838085-0	2020	Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer.	Androgens	0-8	dynamin 1 like	Homo sapiens	31-35
31838085-4	2020	Here, we demonstrate increased levels of dynamin-related protein 1 (DRP1), a mitochondrial fission mediator, in androgen-sensitive and castration-resistant AR-driven PCa.	Androgens	112-120	dynamin 1 like	Homo sapiens	41-66
31838085-4	2020	Here, we demonstrate increased levels of dynamin-related protein 1 (DRP1), a mitochondrial fission mediator, in androgen-sensitive and castration-resistant AR-driven PCa.	Androgens	112-120	dynamin 1 like	Homo sapiens	68-72
31838085-6	2020	DRP1 inhibition activates the cellular metabolic stress response, which involves AMPK phosphorylation, induction of autophagy, and the ER unfolded protein response, and attenuates androgen-induced proliferation.	Androgens	180-188	dynamin 1 like	Homo sapiens	0-4
31972082-3	2020	Dynamin-related protein-1 (Drp1) is a guanosine triphosphatase (GTPase), which plays a prevailing role in mitochondrial fission.	Guanosine	38-47	dynamin 1 like	Homo sapiens	0-25
31972082-3	2020	Dynamin-related protein-1 (Drp1) is a guanosine triphosphatase (GTPase), which plays a prevailing role in mitochondrial fission.	Guanosine	38-47	dynamin 1 like	Homo sapiens	27-31
31972082-5	2020	Here, we synthesized peptide LIQ, an 11-amino acid peptide derived from Drp1-x01 isoform, and reported that LIQ could induce tubulin assembly in vitro.	Amino Acids	37-50	dynamin 1 like	Homo sapiens	72-76
31705926-4	2020	The neurotoxin 6-hydroxydopamine (6-OHDA) treated with SH-SY5Y cells decreased OPA1 and mitofusin 2 fusion proteins, but increased fission 1 and dynamin related protein 1 (DRP1) fission proteins.	Oxidopamine	15-32	dynamin 1 like	Homo sapiens	145-170
31705926-4	2020	The neurotoxin 6-hydroxydopamine (6-OHDA) treated with SH-SY5Y cells decreased OPA1 and mitofusin 2 fusion proteins, but increased fission 1 and dynamin related protein 1 (DRP1) fission proteins.	Oxidopamine	15-32	dynamin 1 like	Homo sapiens	172-176
31705926-4	2020	The neurotoxin 6-hydroxydopamine (6-OHDA) treated with SH-SY5Y cells decreased OPA1 and mitofusin 2 fusion proteins, but increased fission 1 and dynamin related protein 1 (DRP1) fission proteins.	Oxidopamine	34-40	dynamin 1 like	Homo sapiens	145-170
31705926-4	2020	The neurotoxin 6-hydroxydopamine (6-OHDA) treated with SH-SY5Y cells decreased OPA1 and mitofusin 2 fusion proteins, but increased fission 1 and dynamin related protein 1 (DRP1) fission proteins.	Oxidopamine	34-40	dynamin 1 like	Homo sapiens	172-176
32012656-11	2020	However, taking into account the favorable effects in our study, we suggest that bezafibrate could be offered as a treatment option for patients with certain DNM1L mutations.	Bezafibrate	81-92	dynamin 1 like	Homo sapiens	158-163
31868880-2	2020	The key player in mitochondrial fission is dynamin-related protein 1 (DRP1), a cytosolic protein encoded by dynamin 1-like (DNM1L) gene, which relocalizes to the outer mitochondrial membrane, where it assembles, oligomerizes and drives mitochondrial division upon guanosine-5"-triphosphate (GTP) hydrolysis.	Guanosine Triphosphate	264-289	dynamin 1 like	Homo sapiens	43-68
31868880-2	2020	The key player in mitochondrial fission is dynamin-related protein 1 (DRP1), a cytosolic protein encoded by dynamin 1-like (DNM1L) gene, which relocalizes to the outer mitochondrial membrane, where it assembles, oligomerizes and drives mitochondrial division upon guanosine-5"-triphosphate (GTP) hydrolysis.	Guanosine Triphosphate	264-289	dynamin 1 like	Homo sapiens	70-74
31868880-2	2020	The key player in mitochondrial fission is dynamin-related protein 1 (DRP1), a cytosolic protein encoded by dynamin 1-like (DNM1L) gene, which relocalizes to the outer mitochondrial membrane, where it assembles, oligomerizes and drives mitochondrial division upon guanosine-5"-triphosphate (GTP) hydrolysis.	Guanosine Triphosphate	291-294	dynamin 1 like	Homo sapiens	43-68
31868880-2	2020	The key player in mitochondrial fission is dynamin-related protein 1 (DRP1), a cytosolic protein encoded by dynamin 1-like (DNM1L) gene, which relocalizes to the outer mitochondrial membrane, where it assembles, oligomerizes and drives mitochondrial division upon guanosine-5"-triphosphate (GTP) hydrolysis.	Guanosine Triphosphate	291-294	dynamin 1 like	Homo sapiens	70-74
31868880-7	2020	Patient"s fibroblasts show hyperfused/balloon-like giant mitochondria, highlighting the importance of D146 residue for DRP1 function.	d146	102-106	dynamin 1 like	Homo sapiens	119-123
32529365-3	2020	In this chapter, using Drp1 as an example, we demonstrate for the first time, the application of MST to the determination of DSP-lipid interactions and the accurate measurement of KD under physiologically relevant solution conditions.	Disodium hydrogen phosphate	125-128	dynamin 1 like	Homo sapiens	23-27
32529374-2	2020	Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial division, self-assembles into a helical polymer around pre-marked scission sites and generates the constriction force necessary to sever the organelle.	Polymers	107-114	dynamin 1 like	Homo sapiens	0-25
32529374-2	2020	Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial division, self-assembles into a helical polymer around pre-marked scission sites and generates the constriction force necessary to sever the organelle.	Polymers	107-114	dynamin 1 like	Homo sapiens	27-31
32529374-4	2020	The high-resolution images provided by the laser scanning confocal microscope facilitate the observation of the finer details of mitochondrial structure as well as Drp1 polymer dynamics in real time.	Polymers	169-176	dynamin 1 like	Homo sapiens	164-168
31612353-7	2020	In addition, silibinin treatment increases mitochondrial fusion through down-regulating the expression of mitochondrial fission-associated protein dynamin-related protein 1 (DRP1) and up-regulating the expression of mitochondrial fusion-associated proteins, optic atrophy 1, mitofusin 1 and mitofusin 2.	Silybin	13-22	dynamin 1 like	Homo sapiens	174-178
31756635-10	2020	Both ROS and Ca2+-mediated signaling pathways played important roles in acetaldehyde-induced Drp1 phosphorylation.	Reactive Oxygen Species	5-8	dynamin 1 like	Homo sapiens	93-97
31756635-10	2020	Both ROS and Ca2+-mediated signaling pathways played important roles in acetaldehyde-induced Drp1 phosphorylation.	Acetaldehyde	72-84	dynamin 1 like	Homo sapiens	93-97
31822044-7	2019	ALR overexpression additionally had an impact on phosphorylation of Drp1 Ser637 during AKI.	seryl-seryl-seryl-arginine	73-76	dynamin 1 like	Homo sapiens	68-72
31622878-0	2019	Blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes.	chromium hexavalent ion	72-78	dynamin 1 like	Homo sapiens	20-24
32529362-5	2020	To determine the ability of Drp1 to self-assemble, we induce Drp1 polymerization through addition of a non-hydrolyzable GTP analogue.	Guanosine Triphosphate	120-123	dynamin 1 like	Homo sapiens	61-65
31756635-0	2020	Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and Ca2+ levels.	Acetaldehyde	0-12	dynamin 1 like	Homo sapiens	40-65
31756635-0	2020	Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and Ca2+ levels.	Reactive Oxygen Species	124-127	dynamin 1 like	Homo sapiens	40-65
31756635-5	2020	Further analyses showed that acetaldehyde induced the phosphorylation of mitochondrial fission related protein dynamin-related protein 1 (Drp1) at Ser616 and promoted its translocation to mitochondria.	Acetaldehyde	29-41	dynamin 1 like	Homo sapiens	111-136
31756635-5	2020	Further analyses showed that acetaldehyde induced the phosphorylation of mitochondrial fission related protein dynamin-related protein 1 (Drp1) at Ser616 and promoted its translocation to mitochondria.	Acetaldehyde	29-41	dynamin 1 like	Homo sapiens	138-142
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Reactive Oxygen Species	66-89	dynamin 1 like	Homo sapiens	17-21
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Reactive Oxygen Species	66-89	dynamin 1 like	Homo sapiens	303-307
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Reactive Oxygen Species	91-94	dynamin 1 like	Homo sapiens	17-21
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Reactive Oxygen Species	91-94	dynamin 1 like	Homo sapiens	303-307
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Acetylcysteine	201-220	dynamin 1 like	Homo sapiens	17-21
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Acetylcysteine	222-225	dynamin 1 like	Homo sapiens	17-21
31756635-6	2020	The elevation of Drp1 phosphorylation was partly dependent on the reactive oxygen species (ROS)-mediated activation of c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), as N-acetyl-l-cysteine (NAC) pretreatment inhibited the activation of JNK and p38 MAPK while attenuating Drp1 phosphorylation in acetaldehyde-treated cells.	Acetaldehyde	327-339	dynamin 1 like	Homo sapiens	17-21
31756635-8	2020	Pretreatment of CaMKII inhibitor prevented Drp1 phosphorylation in acetaldehyde-treated cells and ameliorated acetaldehyde-induced cytotoxicity, suggesting that CaMKII was a key effector mediating acetaldehyde-induced Drp1 phosphorylation and mitochondrial dysfunction.	Acetaldehyde	67-79	dynamin 1 like	Homo sapiens	43-47
31756635-8	2020	Pretreatment of CaMKII inhibitor prevented Drp1 phosphorylation in acetaldehyde-treated cells and ameliorated acetaldehyde-induced cytotoxicity, suggesting that CaMKII was a key effector mediating acetaldehyde-induced Drp1 phosphorylation and mitochondrial dysfunction.	Acetaldehyde	67-79	dynamin 1 like	Homo sapiens	218-222
31756635-9	2020	Taken together, acetaldehyde induced cytotoxicity by promoting excessive Drp1 phosphorylation and mitochondrial fragmentation.	Acetaldehyde	16-28	dynamin 1 like	Homo sapiens	73-77
31622878-7	2019	We also demonstrated that treatment with dynamic-like protein 1 (DLP1)-siRNA rescued mitochondrial dysfunction in Cr(VI)-exposed L02 hepatocytes.	chromium hexavalent ion	114-120	dynamin 1 like	Homo sapiens	41-63
31622878-7	2019	We also demonstrated that treatment with dynamic-like protein 1 (DLP1)-siRNA rescued mitochondrial dysfunction in Cr(VI)-exposed L02 hepatocytes.	chromium hexavalent ion	114-120	dynamin 1 like	Homo sapiens	65-69
31622878-8	2019	We reached the conclusion that blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes, which may provide the new avenue for developing effective strategies to protect against Cr(VI)-induced hepatotoxicity.	chromium hexavalent ion	103-109	dynamin 1 like	Homo sapiens	51-55
31920551-10	2019	DRP-1 overexpression in HEI-OC1 cells initiated mitophagy and preserved mitochondrial function when exposed to H2O2, while cells with DRP-1 silencing displayed otherwise.	Water	111-115	dynamin 1 like	Homo sapiens	0-5
31587467-2	2019	We report the case of an 8-month-old female with autosomal dominant, de novo DNM1L c. 1228G>A (p. E410K) mutation and mitochondrial disorder, septo-optic dysplasia, hypotonia, developmental delay, elevated blood lactate, and severe mitochondrial cardiomyopathy leading to nonischemic congestive heart failure and cardiogenic shock resulting in death.	Lactic Acid	212-219	dynamin 1 like	Homo sapiens	77-82
31636463-4	2019	The hypoxic tumor microenvironment drove the sustained activation of mechanistic target of rapamycin-GTPase dynamin-related protein 1 (mTOR-Drp1) in NK cells, resulting in excessive mitochondrial fission into fragments.	Sirolimus	91-100	dynamin 1 like	Homo sapiens	140-144
31676320-9	2019	Therefore, these results demonstrate that inhibition of p38 activity prevents CdCl2-induced apoptotic GC-2spd cell death by reducing depolarization of mitochondrial membrane potential and mitochondrial ROS levels via ERK phosphorylation in a signal pathway different from the CdCl2-induced ERK/Drp1/p38 axis and suggest a therapeutic strategy for CdCl2-induced male infertility.	Cadmium Chloride	78-83	dynamin 1 like	Homo sapiens	294-298
32576130-10	2020	Moreover, shikonin reduced the nuclear entry of DNA repair-associated enzymes and increased radiation sensitivity, suggesting that reducing DRP1 expression could inhibit DNA repair and increase the radiation sensitivity of GBM cells.	shikonin	10-18	dynamin 1 like	Homo sapiens	140-144
31115753-0	2019	Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission.	diallyl trisulfide	0-18	dynamin 1 like	Homo sapiens	91-95
31533986-0	2019	The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria.	Serine	30-33	dynamin 1 like	Homo sapiens	41-66
31533986-0	2019	The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria.	Serine	30-33	dynamin 1 like	Homo sapiens	68-72
31533986-2	2019	Reversible Drp1 phosphorylation has been implicated in the regulation of this process, but whether Drp1 phosphorylation at Ser-637 determines its subcellular localization and fission activity remains to be fully elucidated.	Serine	123-126	dynamin 1 like	Homo sapiens	99-103
31533986-3	2019	Here, using HEK 293T cells and immunofluorescence, immunoblotting, RNAi, subcellular fractionation, co-immunoprecipitation assays, and CRISPR/Cas9 genome editing, we show that Drp1 phosphorylated at Ser-637 (Drp1pS637) resides both in the cytosol and on mitochondria.	Serine	199-202	dynamin 1 like	Homo sapiens	176-180
31533986-5	2019	We also noted that protein kinase A (PKA), which mediates phosphorylation of Drp1 on Ser-637, is partially present on mitochondria and interacts with both MIEFs and Mff.	Serine	85-88	dynamin 1 like	Homo sapiens	77-81
31533986-9	2019	In conclusion, the Ser-637 phosphorylation status in Drp1 is not a determinant that controls Drp1 recruitment to mitochondria.	Serine	19-22	dynamin 1 like	Homo sapiens	53-57
31676320-0	2019	Increasing ERK phosphorylation by inhibition of p38 activity protects against cadmium-induced apoptotic cell death through ERK/Drp1/p38 signaling axis in spermatocyte-derived GC-2spd cells.	Cadmium	78-85	dynamin 1 like	Homo sapiens	127-131
31676320-2	2019	CdCl2 also induces mitochondrial fission by increasing dynamin-related protein 1 (Drp1) expression as well as the mitochondria-dependent apoptosis pathway by extracellular signal-regulated kinase (ERK) activation.	Cadmium Chloride	0-5	dynamin 1 like	Homo sapiens	55-80
31676320-2	2019	CdCl2 also induces mitochondrial fission by increasing dynamin-related protein 1 (Drp1) expression as well as the mitochondria-dependent apoptosis pathway by extracellular signal-regulated kinase (ERK) activation.	Cadmium Chloride	0-5	dynamin 1 like	Homo sapiens	82-86
31676320-5	2019	Moreover, CdCl2-induced cell death is closely associated with the ERK/Drp1/p38 signaling axis.	Cadmium Chloride	10-15	dynamin 1 like	Homo sapiens	70-74
31676320-7	2019	Knockdown of Drp1 expression diminished CdCl2-induced mitochondrial deformation and ROS generation and protected GC-2spd cells from apoptotic cell death.	Cadmium Chloride	40-45	dynamin 1 like	Homo sapiens	13-17
31770286-7	2019	RESULTS: Drp1 was significantly overexpressed in lung cancer tissues based on Oncomine and TCGA databases (P < .05).	oncomine	78-86	dynamin 1 like	Homo sapiens	9-13
31115753-4	2019	RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression.	diallyl trisulfide	9-13	dynamin 1 like	Homo sapiens	241-266
31115753-4	2019	RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression.	diallyl trisulfide	9-13	dynamin 1 like	Homo sapiens	268-272
31115753-4	2019	RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression.	Glucose	53-60	dynamin 1 like	Homo sapiens	268-272
31115753-4	2019	RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression.	Glucose	225-232	dynamin 1 like	Homo sapiens	241-266
31115753-5	2019	Furthermore, DATS blockage of high glucose-induced mitochondrial fission and apoptosis was through adenosine monophosphate-activated protein kinase (AMPK) activation-inhibited Drp1 expression in HUVECs.	Glucose	35-42	dynamin 1 like	Homo sapiens	176-180
31115753-6	2019	CONCLUSIONS: DATS demonstrated the ability to inhibit high glucose-induced HUVEC apoptosis via suppression of Drp1-mediated mitochondrial fission in an AMPK-dependent fashion.	diallyl trisulfide	13-17	dynamin 1 like	Homo sapiens	110-114
31115753-6	2019	CONCLUSIONS: DATS demonstrated the ability to inhibit high glucose-induced HUVEC apoptosis via suppression of Drp1-mediated mitochondrial fission in an AMPK-dependent fashion.	Glucose	59-66	dynamin 1 like	Homo sapiens	110-114
31413070-6	2019	We have previously shown that calcium-induced actin stimulates increases in both mitochondrial calcium and recruitment of the dynamin GTPase Drp1.	Calcium	30-37	dynamin 1 like	Homo sapiens	141-145
31363041-5	2019	LPC-induced mitoROS mediated the activation of protein kinase C (PKC)alpha, which interacted with and phosphorylated dynamin-related protein 1 (Drp1) at Ser616, thereby increasing Drp1-mediated mitochondrial fission and mitochondrial depolarization.	Lysophosphatidylcholines	0-3	dynamin 1 like	Homo sapiens	117-142
31305892-6	2019	The effect of CSF treatment on the morphology of mitochondria was characterized by phosphorylation of serine 637 on the dynamin-related protein DRP1, a post-translational modification responsible for unopposed mitochondrial fusion in response to low glucose conditions.	Serine	102-108	dynamin 1 like	Homo sapiens	144-148
31305892-6	2019	The effect of CSF treatment on the morphology of mitochondria was characterized by phosphorylation of serine 637 on the dynamin-related protein DRP1, a post-translational modification responsible for unopposed mitochondrial fusion in response to low glucose conditions.	Glucose	250-257	dynamin 1 like	Homo sapiens	144-148
31363041-5	2019	LPC-induced mitoROS mediated the activation of protein kinase C (PKC)alpha, which interacted with and phosphorylated dynamin-related protein 1 (Drp1) at Ser616, thereby increasing Drp1-mediated mitochondrial fission and mitochondrial depolarization.	Lysophosphatidylcholines	0-3	dynamin 1 like	Homo sapiens	144-148
31363041-5	2019	LPC-induced mitoROS mediated the activation of protein kinase C (PKC)alpha, which interacted with and phosphorylated dynamin-related protein 1 (Drp1) at Ser616, thereby increasing Drp1-mediated mitochondrial fission and mitochondrial depolarization.	Lysophosphatidylcholines	0-3	dynamin 1 like	Homo sapiens	180-184
31363041-6	2019	Furthermore, inhibition of PKCalpha and Drp1 reduced FoxO1-mediated phosphorylation at Ser256 and nuclear accumulation, which suppressed COX-2/PGE2 expression and collagen production.	Dinoprostone	143-147	dynamin 1 like	Homo sapiens	40-44
31363041-7	2019	Moreover, pretreatment with celecoxib or COX-2 siRNA suppressed WT FoxO1; mutated Ser256-to-Asp256 FoxO1-enhanced collagen induction, which was reversed by addition of PGE2 Our results demonstrate that LPC-induced generation of mitoROS regulates PKCalpha-mediated Drp1-dependent mitochondrial fission and COX-2 expression via a PKCalpha/Drp1/FoxO1 cascade, leading to PGE2/EP4-mediated collagen induction.	Celecoxib	28-37	dynamin 1 like	Homo sapiens	264-268
31363041-7	2019	Moreover, pretreatment with celecoxib or COX-2 siRNA suppressed WT FoxO1; mutated Ser256-to-Asp256 FoxO1-enhanced collagen induction, which was reversed by addition of PGE2 Our results demonstrate that LPC-induced generation of mitoROS regulates PKCalpha-mediated Drp1-dependent mitochondrial fission and COX-2 expression via a PKCalpha/Drp1/FoxO1 cascade, leading to PGE2/EP4-mediated collagen induction.	Celecoxib	28-37	dynamin 1 like	Homo sapiens	337-341
31363041-7	2019	Moreover, pretreatment with celecoxib or COX-2 siRNA suppressed WT FoxO1; mutated Ser256-to-Asp256 FoxO1-enhanced collagen induction, which was reversed by addition of PGE2 Our results demonstrate that LPC-induced generation of mitoROS regulates PKCalpha-mediated Drp1-dependent mitochondrial fission and COX-2 expression via a PKCalpha/Drp1/FoxO1 cascade, leading to PGE2/EP4-mediated collagen induction.	Dinoprostone	168-172	dynamin 1 like	Homo sapiens	264-268
31363041-7	2019	Moreover, pretreatment with celecoxib or COX-2 siRNA suppressed WT FoxO1; mutated Ser256-to-Asp256 FoxO1-enhanced collagen induction, which was reversed by addition of PGE2 Our results demonstrate that LPC-induced generation of mitoROS regulates PKCalpha-mediated Drp1-dependent mitochondrial fission and COX-2 expression via a PKCalpha/Drp1/FoxO1 cascade, leading to PGE2/EP4-mediated collagen induction.	Dinoprostone	168-172	dynamin 1 like	Homo sapiens	337-341
31285421-0	2019	Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes.	Cadmium	81-88	dynamin 1 like	Homo sapiens	0-4
31387295-4	2019	CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs).	bardoxolone methyl	0-7	dynamin 1 like	Homo sapiens	18-44
31387295-4	2019	CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs).	bardoxolone methyl	0-7	dynamin 1 like	Homo sapiens	46-50
31387295-4	2019	CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs).	Serine	52-58	dynamin 1 like	Homo sapiens	18-44
31387295-4	2019	CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs).	Serine	52-58	dynamin 1 like	Homo sapiens	46-50
31387295-5	2019	In addition, CDDO-Me facilitated DRP1-mediated mitochondrial fissions, which selectively attenuated SE-induced CA1 neuronal death.	bardoxolone methyl	13-20	dynamin 1 like	Homo sapiens	33-37
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Silybin	100-109	dynamin 1 like	Homo sapiens	26-30
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Silybin	100-109	dynamin 1 like	Homo sapiens	59-63
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Silybin	100-109	dynamin 1 like	Homo sapiens	59-63
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Staurosporine	204-217	dynamin 1 like	Homo sapiens	59-63
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Staurosporine	204-217	dynamin 1 like	Homo sapiens	59-63
31285421-5	2019	We aimed to explore the role and mechanism of Drp1 interaction with RB in hepatocyte"s necroptosis caused by cadmium (Cd).	Cadmium	109-116	dynamin 1 like	Homo sapiens	46-50
31285421-5	2019	We aimed to explore the role and mechanism of Drp1 interaction with RB in hepatocyte"s necroptosis caused by cadmium (Cd).	Cadmium	118-120	dynamin 1 like	Homo sapiens	46-50
31285421-8	2019	Moreover, Drp1 and RB protein were up-regulated and translocated to mitochondria in CdCl2-exposed hepatocytes.	Cadmium Chloride	84-89	dynamin 1 like	Homo sapiens	10-14
31285421-9	2019	Inhibition of Drp1 with siRNA (siDNM1L) or inhibitors not only suppressed the RB expression and its mitochondrial translocation, but also alleviated MQC disorder, necroptosis, and hepatotoxicity caused by CdCl2.	Cadmium Chloride	205-210	dynamin 1 like	Homo sapiens	14-18
31285421-10	2019	Moreover, blocking Drp1 with metformin rescued necroptosis and hepatic injury triggered by CdCl2.	Metformin	29-38	dynamin 1 like	Homo sapiens	19-23
31285421-10	2019	Moreover, blocking Drp1 with metformin rescued necroptosis and hepatic injury triggered by CdCl2.	Cadmium Chloride	91-96	dynamin 1 like	Homo sapiens	19-23
31285421-11	2019	RB was proved to directly interact with Drp1 at mitochondria to form a complex which then bound to receptor interaction protein kinase (RIPK3) and enhanced the formation of necrosome after CdCl2 exposure.	Cadmium Chloride	189-194	dynamin 1 like	Homo sapiens	40-44
31285421-12	2019	In summary, we found a new molecular mechanism of regulated cell death that Drp1 interacted with RB and promoted them mitochondrial translocation to mediate necroptosis and hepatic injury in hepatocytes induced by Cd-exposure.	Cadmium	214-216	dynamin 1 like	Homo sapiens	76-80
31189900-0	2019	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass.	Calcium	43-50	dynamin 1 like	Homo sapiens	0-4
30927279-12	2019	Moreover, NaHS alleviated ROS, increased mitochondrial membrane potential, decreased DRP1 but enhanced OPA1 expression in skin fibroblasts after scratch.	sodium bisulfide	10-14	dynamin 1 like	Homo sapiens	85-89
30767411-3	2019	In addition, various AD-related insults such as exposure to glutamate, soluble amyloid-beta oligomers, or reagents inducing tau hyperphosphorylation (i.e., okadaic acid) led to calpain-dependent cleavage of DLP1 in primary cortical neurons.	Glutamic Acid	60-69	dynamin 1 like	Homo sapiens	207-211
30767411-3	2019	In addition, various AD-related insults such as exposure to glutamate, soluble amyloid-beta oligomers, or reagents inducing tau hyperphosphorylation (i.e., okadaic acid) led to calpain-dependent cleavage of DLP1 in primary cortical neurons.	Okadaic Acid	156-168	dynamin 1 like	Homo sapiens	207-211
30171839-0	2018	Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer"s Disease.	Ursodeoxycholic Acid	0-20	dynamin 1 like	Homo sapiens	71-75
31308800-9	2019	Together, these findings suggest that the phosphorylation of Drp1(S616) by CDK5 is involved in mitochondrial fission in the substantia nigra of a non-human primate model of MPTP-induced PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	173-177	dynamin 1 like	Homo sapiens	61-65
30317624-9	2019	These results indicated that Drp1 may function as a key factor in asthma airway remodeling by mediating ASMC proliferation and cell cycle acceleration through an effect on mitochondrial metabolic disturbance.	asmc	104-108	dynamin 1 like	Homo sapiens	29-33
31019453-2	2019	Our data demonstrate that Drp1 regulates the transcriptional program induced by retinoic acid (RA), leading to neuronal differentiation.	Tretinoin	80-93	dynamin 1 like	Homo sapiens	26-30
31019453-2	2019	Our data demonstrate that Drp1 regulates the transcriptional program induced by retinoic acid (RA), leading to neuronal differentiation.	Tretinoin	95-97	dynamin 1 like	Homo sapiens	26-30
30944818-0	2019	Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model.	Rifampin	48-58	dynamin 1 like	Homo sapiens	25-29
30944818-0	2019	Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model.	Isoniazid	64-73	dynamin 1 like	Homo sapiens	25-29
30703167-3	2019	Here, we showed that the interaction between Drp1 and MiD51 is regulated by GTP binding and depends on the polymerization of Drp1.	Guanosine Triphosphate	76-79	dynamin 1 like	Homo sapiens	45-49
30703167-3	2019	Here, we showed that the interaction between Drp1 and MiD51 is regulated by GTP binding and depends on the polymerization of Drp1.	Guanosine Triphosphate	76-79	dynamin 1 like	Homo sapiens	125-129
30581142-3	2019	Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn2+ entry through the Zip1-MCU complex.	Zinc	177-181	dynamin 1 like	Homo sapiens	68-72
30347228-10	2018	The H2O2-treated EH cells showed diminished Gli1 and increased Drp1 expression, concurrent with reduced p-Drp1-(serine637).	Hydrogen Peroxide	4-8	dynamin 1 like	Homo sapiens	63-67
30347228-10	2018	The H2O2-treated EH cells showed diminished Gli1 and increased Drp1 expression, concurrent with reduced p-Drp1-(serine637).	Hydrogen Peroxide	4-8	dynamin 1 like	Homo sapiens	106-110
30347228-10	2018	The H2O2-treated EH cells showed diminished Gli1 and increased Drp1 expression, concurrent with reduced p-Drp1-(serine637).	serine637	112-121	dynamin 1 like	Homo sapiens	106-110
30347228-11	2018	Whereas rShh pre-treated EH cells presented normal mitochondrial dynamics with dense, long networks of mitochondria alongwith nuclear accumulation of Gli1 and the decreased expression of Drp1.	rshh	8-12	dynamin 1 like	Homo sapiens	187-191
28644713-0	2018	An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.	saturated	88-97	dynamin 1 like	Homo sapiens	78-82
28644713-0	2018	An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.	Phosphatidic Acids	98-115	dynamin 1 like	Homo sapiens	78-82
28644713-3	2018	We previously showed that Drp1 interacts with phosphatidic acid (PA) and saturated phospholipids in the mitochondrial membrane, and this interaction restrains Drp1 in initiating the constriction of mitochondria.	Phosphatidic Acids	46-63	dynamin 1 like	Homo sapiens	26-30
28644713-3	2018	We previously showed that Drp1 interacts with phosphatidic acid (PA) and saturated phospholipids in the mitochondrial membrane, and this interaction restrains Drp1 in initiating the constriction of mitochondria.	Phosphatidic Acids	46-63	dynamin 1 like	Homo sapiens	159-163
28644713-3	2018	We previously showed that Drp1 interacts with phosphatidic acid (PA) and saturated phospholipids in the mitochondrial membrane, and this interaction restrains Drp1 in initiating the constriction of mitochondria.	Phosphatidic Acids	65-67	dynamin 1 like	Homo sapiens	26-30
28644713-3	2018	We previously showed that Drp1 interacts with phosphatidic acid (PA) and saturated phospholipids in the mitochondrial membrane, and this interaction restrains Drp1 in initiating the constriction of mitochondria.	Phosphatidic Acids	65-67	dynamin 1 like	Homo sapiens	159-163
28644713-3	2018	We previously showed that Drp1 interacts with phosphatidic acid (PA) and saturated phospholipids in the mitochondrial membrane, and this interaction restrains Drp1 in initiating the constriction of mitochondria.	Phospholipids	83-96	dynamin 1 like	Homo sapiens	26-30
28644713-4	2018	Here, we show that the role of saturated acyl chains of phospholipids is independent of their contribution to the membrane curvature or lipid packing suggesting their direct interaction with Drp1.	Phospholipids	56-69	dynamin 1 like	Homo sapiens	191-195
28644713-5	2018	We further show that an unstructured loop in the stalk domain of Drp1 is critical for interaction with unsaturated PA.	Phosphatidic Acids	115-117	dynamin 1 like	Homo sapiens	65-69
30377844-3	2018	Two kinds of polysaccharides in the leaves, DLP-1 and DLP-2, were obtained by hot water extraction, alcohol sedimentation and chromatographic separation (DEAE-52 cellulose column and Sephadex G-100 column).	Polysaccharides	13-28	dynamin 1 like	Homo sapiens	44-49
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Galactose	22-37	dynamin 1 like	Homo sapiens	0-5
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Arabinose	39-51	dynamin 1 like	Homo sapiens	0-5
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Rhamnose	57-71	dynamin 1 like	Homo sapiens	0-5
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Xylose	124-132	dynamin 1 like	Homo sapiens	0-5
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Glucose	134-143	dynamin 1 like	Homo sapiens	0-5
30377844-6	2018	DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose.	Mannose	149-162	dynamin 1 like	Homo sapiens	0-5
30377844-9	2018	The results indicated that DLP-1 (5 mug/mL) and DLP-2 (50 mug/mL) were effective in protecting THP-1 cells from LPS-stimulated cytotoxicity, as well as inhibiting reactive oxygen species formation.	Reactive Oxygen Species	163-186	dynamin 1 like	Homo sapiens	27-32
29890853-9	2019	Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637).	Serine	148-154	dynamin 1 like	Homo sapiens	42-67
29890853-9	2019	Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637).	Serine	148-154	dynamin 1 like	Homo sapiens	69-73
29890853-9	2019	Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637).	Serine	148-154	dynamin 1 like	Homo sapiens	140-144
29890853-9	2019	Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637).	Serine	148-154	dynamin 1 like	Homo sapiens	140-144
30539788-9	2019	During the digestion of AHs, macrophage mTORC1 was activated and coupled with dynamin-related protein 1 to facilitate the latter"s phosphorylation, leading to mitochondrial fission-mediated calcium release.	Calcium	190-197	dynamin 1 like	Homo sapiens	78-103
30171839-10	2018	Drp1 protein amount and localization were increased after UDCA treatment.	Ursodeoxycholic Acid	58-62	dynamin 1 like	Homo sapiens	0-4
30171839-11	2018	The restorative effects of UDCA are abolished when Drp1 is knocked down.	Ursodeoxycholic Acid	27-31	dynamin 1 like	Homo sapiens	51-55
29768044-0	2018	CoCl2 induces apoptosis via a ROS-dependent pathway and Drp1-mediated mitochondria fission in periodontal ligament stem cells.	cobaltous chloride	0-5	dynamin 1 like	Homo sapiens	56-60
29953931-5	2018	Our studies show that expression of constitutively active RhoA in cardiomyocytes increases phosphorylation of Dynamin-related protein 1 (Drp1) at serine-616, and leads to localization of Drp1 at mitochondria.	Serine	146-152	dynamin 1 like	Homo sapiens	110-135
29953931-5	2018	Our studies show that expression of constitutively active RhoA in cardiomyocytes increases phosphorylation of Dynamin-related protein 1 (Drp1) at serine-616, and leads to localization of Drp1 at mitochondria.	Serine	146-152	dynamin 1 like	Homo sapiens	137-141
29953931-7	2018	Endogenous RhoA activation by the GPCR agonist sphingosine-1-phosphate (S1P) also increases Drp1 phosphorylation and its mitochondrial translocation in a RhoA and ROCK dependent manner.	sphingosine 1-phosphate	47-70	dynamin 1 like	Homo sapiens	92-96
30007356-7	2018	Beneficial effects of GSK773 are also likely due to stimulation of mitochondrial biogenesis and induction of mitochondrial fusion, by decreasing dynamin-related protein 1 and increasing mitofusin 2.	gsk773	22-28	dynamin 1 like	Homo sapiens	145-170
30241351-6	2018	DHEA prevents mitochondrial dysfunction by decreasing the activation of DNM1L and MFF, and increasing MFN1 expression.	Dehydroepiandrosterone	0-4	dynamin 1 like	Homo sapiens	72-77
29768044-6	2018	Importantly, CoCl2 increased the expression of dynamin-related protein 1 (Drp1), the major regulator in mitochondrial fission, in PDLSCs.	cobaltous chloride	13-18	dynamin 1 like	Homo sapiens	47-72
29768044-6	2018	Importantly, CoCl2 increased the expression of dynamin-related protein 1 (Drp1), the major regulator in mitochondrial fission, in PDLSCs.	cobaltous chloride	13-18	dynamin 1 like	Homo sapiens	74-78
29768044-7	2018	Mitochondrial division inhibitor-1, pharmacological inhibition of Drp1, not only inhibited mitochondrial fission but also protected against CoCl2-induced PDLSC dysfunction, as shown by increased mitochondrial membrane potential, increased ATP level, reduced reactive oxygen species (ROS) level, and decreased apoptosis.	cobaltous chloride	140-145	dynamin 1 like	Homo sapiens	66-70
29768044-7	2018	Mitochondrial division inhibitor-1, pharmacological inhibition of Drp1, not only inhibited mitochondrial fission but also protected against CoCl2-induced PDLSC dysfunction, as shown by increased mitochondrial membrane potential, increased ATP level, reduced reactive oxygen species (ROS) level, and decreased apoptosis.	Adenosine Triphosphate	239-242	dynamin 1 like	Homo sapiens	66-70
29768044-7	2018	Mitochondrial division inhibitor-1, pharmacological inhibition of Drp1, not only inhibited mitochondrial fission but also protected against CoCl2-induced PDLSC dysfunction, as shown by increased mitochondrial membrane potential, increased ATP level, reduced reactive oxygen species (ROS) level, and decreased apoptosis.	Reactive Oxygen Species	258-281	dynamin 1 like	Homo sapiens	66-70
29768044-7	2018	Mitochondrial division inhibitor-1, pharmacological inhibition of Drp1, not only inhibited mitochondrial fission but also protected against CoCl2-induced PDLSC dysfunction, as shown by increased mitochondrial membrane potential, increased ATP level, reduced reactive oxygen species (ROS) level, and decreased apoptosis.	Reactive Oxygen Species	283-286	dynamin 1 like	Homo sapiens	66-70
29768044-8	2018	Furthermore, N-acety-l-cysteine, a pharmacological inhibitor of ROS, also abolished CoCl2-induced expression of Drp1 and protected against CoCl2-induced PDLSC dysfunction, as shown by restored mitochondrial membrane potential, ATP level, inhibited mitochondrial fission, and decreased apoptosis.	Acetylcysteine	13-31	dynamin 1 like	Homo sapiens	112-116
29768044-8	2018	Furthermore, N-acety-l-cysteine, a pharmacological inhibitor of ROS, also abolished CoCl2-induced expression of Drp1 and protected against CoCl2-induced PDLSC dysfunction, as shown by restored mitochondrial membrane potential, ATP level, inhibited mitochondrial fission, and decreased apoptosis.	Reactive Oxygen Species	64-67	dynamin 1 like	Homo sapiens	112-116
29768044-8	2018	Furthermore, N-acety-l-cysteine, a pharmacological inhibitor of ROS, also abolished CoCl2-induced expression of Drp1 and protected against CoCl2-induced PDLSC dysfunction, as shown by restored mitochondrial membrane potential, ATP level, inhibited mitochondrial fission, and decreased apoptosis.	cobaltous chloride	84-89	dynamin 1 like	Homo sapiens	112-116
29768044-8	2018	Furthermore, N-acety-l-cysteine, a pharmacological inhibitor of ROS, also abolished CoCl2-induced expression of Drp1 and protected against CoCl2-induced PDLSC dysfunction, as shown by restored mitochondrial membrane potential, ATP level, inhibited mitochondrial fission, and decreased apoptosis.	Adenosine Triphosphate	227-230	dynamin 1 like	Homo sapiens	112-116
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	Reactive Oxygen Species	65-68	dynamin 1 like	Homo sapiens	69-73
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	Reactive Oxygen Species	65-68	dynamin 1 like	Homo sapiens	168-172
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	cobaltous chloride	109-114	dynamin 1 like	Homo sapiens	69-73
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	cobaltous chloride	109-114	dynamin 1 like	Homo sapiens	168-172
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	Reactive Oxygen Species	160-163	dynamin 1 like	Homo sapiens	69-73
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	cobaltous chloride	228-233	dynamin 1 like	Homo sapiens	69-73
29768044-9	2018	Collectively, our data provide new insights into the role of the ROS-Drp1-dependent mitochondrial pathway in CoCl2-induced apoptosis in PDLSCs, indicating that ROS and Drp1 are promising therapeutic targets for the treatment of CoCl2-induced PDLSC dysfunction.	cobaltous chloride	228-233	dynamin 1 like	Homo sapiens	168-172
30158524-2	2018	DRP1 activity is modulated by phosphorylation and S-nitrosylation on serine and cysteine residues, respectively.	Serine	69-75	dynamin 1 like	Homo sapiens	0-4
29993201-7	2018	Moreover, knockdown of Drp1 markedly blocked IR-783-mediated mitochondrial fission, loss of MMP, ATP depletion, mPTP opening and apoptosis.	Adenosine Triphosphate	97-100	dynamin 1 like	Homo sapiens	23-27
30158524-2	2018	DRP1 activity is modulated by phosphorylation and S-nitrosylation on serine and cysteine residues, respectively.	Cysteine	80-88	dynamin 1 like	Homo sapiens	0-4
30158524-4	2018	In the present study, we found that Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME, a NOS inhibitor) abolished S-nitrosylated (SNO-DRP1) and DRP1-serine (S) 616 phosphorylation levels in CA1 neurons under physiological condition.	L-NAME hydrochloride	36-86	dynamin 1 like	Homo sapiens	143-147
30158524-4	2018	In the present study, we found that Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME, a NOS inhibitor) abolished S-nitrosylated (SNO-DRP1) and DRP1-serine (S) 616 phosphorylation levels in CA1 neurons under physiological condition.	L-NAME hydrochloride	36-86	dynamin 1 like	Homo sapiens	153-157
30158524-4	2018	In the present study, we found that Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME, a NOS inhibitor) abolished S-nitrosylated (SNO-DRP1) and DRP1-serine (S) 616 phosphorylation levels in CA1 neurons under physiological condition.	NG-Nitroarginine Methyl Ester	88-94	dynamin 1 like	Homo sapiens	143-147
30158524-4	2018	In the present study, we found that Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME, a NOS inhibitor) abolished S-nitrosylated (SNO-DRP1) and DRP1-serine (S) 616 phosphorylation levels in CA1 neurons under physiological condition.	NG-Nitroarginine Methyl Ester	88-94	dynamin 1 like	Homo sapiens	153-157
30054507-8	2018	Suppression of DRP1 by HDAC8 was likely mediated by decreasing the level of acetylated histone H3 lysine 27 (a hallmark of active promoters) at the DRP1 promoter.	Lysine	98-104	dynamin 1 like	Homo sapiens	15-19
30054507-8	2018	Suppression of DRP1 by HDAC8 was likely mediated by decreasing the level of acetylated histone H3 lysine 27 (a hallmark of active promoters) at the DRP1 promoter.	Lysine	98-104	dynamin 1 like	Homo sapiens	148-152
30054507-9	2018	Collectively, this study shows that HDAC8 inhibits cytotoxicity induced by cobalt and H/R, in part, through suppressing DRP1 expression and mitochondrial fission.	Cobalt	75-81	dynamin 1 like	Homo sapiens	120-124
30054507-9	2018	Collectively, this study shows that HDAC8 inhibits cytotoxicity induced by cobalt and H/R, in part, through suppressing DRP1 expression and mitochondrial fission.	Arginine	88-89	dynamin 1 like	Homo sapiens	120-124
30022112-2	2018	Distinct intrinsically disordered regions (IDRs) in Drp1 substitute for the canonical pleckstrin homology (PH) domain and proline-rich domain (PRD) of prototypical dynamin, which cooperatively regulate endocytic vesicle scission.	Proline	122-129	dynamin 1 like	Homo sapiens	52-56
30147831-11	2018	Pretreatment with the wortmannin further attenuated these effects induced by EEP and resulted in the expression of proapoptotic phenotypes such as oxidative injury, elevated Beclin1/Bcl-2 ratio, cytochrome c leakage, mitochondrial dynamin-1-like protein (Drp-1) expression, and VDAC1 dephosphorylation.	Wortmannin	22-32	dynamin 1 like	Homo sapiens	255-260
30022112-6	2018	We show that the Drp1 VD is necessary and sufficient for specific Drp1-phospholipid interactions.	Phospholipids	71-83	dynamin 1 like	Homo sapiens	17-21
29431643-18	2018	CONCLUSIONS: In health, MiDs regulate Drp1-mediated fission, whereas in disease, epigenetic upregulation of MiDs increases mitotic fission, which drives pathological proliferation and apoptosis resistance.	mids	24-28	dynamin 1 like	Homo sapiens	38-42
30022112-6	2018	We show that the Drp1 VD is necessary and sufficient for specific Drp1-phospholipid interactions.	Phospholipids	71-83	dynamin 1 like	Homo sapiens	66-70
30022112-7	2018	We further demonstrate that the membrane-dependent VD conformational rearrangement essential for the alleviation of Drp1 auto-inhibition is contingent upon the basal GTP hydrolysis-dependent generation of Drp1 dimers from oligomers in solution.	Guanosine Triphosphate	166-169	dynamin 1 like	Homo sapiens	116-120
30022112-7	2018	We further demonstrate that the membrane-dependent VD conformational rearrangement essential for the alleviation of Drp1 auto-inhibition is contingent upon the basal GTP hydrolysis-dependent generation of Drp1 dimers from oligomers in solution.	Guanosine Triphosphate	166-169	dynamin 1 like	Homo sapiens	205-209
29899447-4	2018	We report that GTP induces a marked elongation and rotation of the GTPase domain, bundle-signalling element and connecting hinge loops of DRP1.	Guanosine Triphosphate	15-18	dynamin 1 like	Homo sapiens	138-142
29684364-6	2018	Mechanistically, endogenous reactive oxygen species (ROS) are necessary for Drp1 activation in vivo, and exogenous ROS insult is sufficient to activate Drp1-dependent mitochondrial fission in cultured photoreceptors.	Reactive Oxygen Species	28-51	dynamin 1 like	Homo sapiens	76-80
29684364-6	2018	Mechanistically, endogenous reactive oxygen species (ROS) are necessary for Drp1 activation in vivo, and exogenous ROS insult is sufficient to activate Drp1-dependent mitochondrial fission in cultured photoreceptors.	Reactive Oxygen Species	53-56	dynamin 1 like	Homo sapiens	76-80
29684364-6	2018	Mechanistically, endogenous reactive oxygen species (ROS) are necessary for Drp1 activation in vivo, and exogenous ROS insult is sufficient to activate Drp1-dependent mitochondrial fission in cultured photoreceptors.	Reactive Oxygen Species	115-118	dynamin 1 like	Homo sapiens	152-156
29684364-8	2018	Collectively, our data delineate an ROS-Drp1-mitochondria axis that promotes photoreceptor degeneration in retinal diseased models.	Reactive Oxygen Species	36-39	dynamin 1 like	Homo sapiens	40-44
29444369-9	2018	Interestingly, RV-NSP4 was found to interact with and be involved in recruiting fission-active pool of Serine 616 phosphoDrp1 (Ser616 pDrp1) to mitochondria independent of accessory adaptors Mitochondrial fission factor and Fission protein 1 (Fis1).	Serine	103-109	dynamin 1 like	Homo sapiens	127-139
29899447-6	2018	After co-assembly, GTP hydrolysis and exchange lead to MID receptor dissociation, filament shortening and curling of DRP1 oligomers into constricted and closed rings.	Guanosine Triphosphate	19-22	dynamin 1 like	Homo sapiens	117-121
28659272-0	2018	p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction.	Aldosterone	50-61	dynamin 1 like	Homo sapiens	4-8
29802333-8	2018	We showed that the upregulated fission induced by niclosamide is accompanied by an increase in the number of large Drp1 oligomers.	Niclosamide	50-61	dynamin 1 like	Homo sapiens	115-119
28659272-5	2018	In an animal model of aldosterone-induced nephropathy, inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) suppressed aldosterone-induced podocyte injury.	Aldosterone	22-33	dynamin 1 like	Homo sapiens	103-128
28659272-5	2018	In an animal model of aldosterone-induced nephropathy, inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) suppressed aldosterone-induced podocyte injury.	Aldosterone	22-33	dynamin 1 like	Homo sapiens	130-134
28659272-5	2018	In an animal model of aldosterone-induced nephropathy, inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) suppressed aldosterone-induced podocyte injury.	Aldosterone	147-158	dynamin 1 like	Homo sapiens	103-128
28659272-5	2018	In an animal model of aldosterone-induced nephropathy, inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) suppressed aldosterone-induced podocyte injury.	Aldosterone	147-158	dynamin 1 like	Homo sapiens	130-134
28659272-6	2018	In cultured podocytes, aldosterone dose dependently induced Drp1 expression.	Aldosterone	23-34	dynamin 1 like	Homo sapiens	60-64
28659272-10	2018	These findings implicated that aldosterone induced mitochondrial dysfunction and podocyte injury mediated by p53/Drp1-dependent mitochondrial fission, which may provide opportunities for therapeutic intervention for podocyte injury.	Aldosterone	31-42	dynamin 1 like	Homo sapiens	113-117
29725013-0	2018	Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.	Iron	0-4	dynamin 1 like	Homo sapiens	154-158
29725013-11	2018	In addition, iron chelation or antioxidant weakened the activity of the AMPK/MFF/Drp1 pathway in MDS-MSCs with IO from several patients, accompanied by attenuation of mitochondrial fragmentation and autophagy.	Iron	13-17	dynamin 1 like	Homo sapiens	81-85
29110115-5	2018	Using patient-generated fibroblasts, we demonstrated both DNM1L variants undergo adverse alterations to mitochondrial structure and function, including impaired mitochondrial fission, reduced membrane potential, and lower oxidative capacity including an increased cellular level of reactive oxygen species (ROS) and dsDNA breaks.	Reactive Oxygen Species	282-305	dynamin 1 like	Homo sapiens	58-63
29361534-4	2018	We found that GTP promoted rapid rearrangement of Drp1 from a uniform distribution to discrete foci, in line with the assembly of Drp1 scaffolds at multiple nucleation sites around the lipid tube.	Guanosine Triphosphate	14-17	dynamin 1 like	Homo sapiens	50-54
29361534-4	2018	We found that GTP promoted rapid rearrangement of Drp1 from a uniform distribution to discrete foci, in line with the assembly of Drp1 scaffolds at multiple nucleation sites around the lipid tube.	Guanosine Triphosphate	14-17	dynamin 1 like	Homo sapiens	130-134
29361534-6	2018	Strikingly, Drp1 polymers stabilized membrane curvatures similar to those of constricted mitochondria against pressure changes.	Polymers	17-25	dynamin 1 like	Homo sapiens	12-16
29110115-5	2018	Using patient-generated fibroblasts, we demonstrated both DNM1L variants undergo adverse alterations to mitochondrial structure and function, including impaired mitochondrial fission, reduced membrane potential, and lower oxidative capacity including an increased cellular level of reactive oxygen species (ROS) and dsDNA breaks.	Reactive Oxygen Species	307-310	dynamin 1 like	Homo sapiens	58-63
29110115-6	2018	Mutation of DNM1L was also associated with impaired responses to oxidative stress, as treatment with hydrogen peroxide dramatically increased cellular ROS, with minimal exacerbation of already impaired mitochondrial function.	Hydrogen Peroxide	101-118	dynamin 1 like	Homo sapiens	12-17
29360568-7	2018	Fatty acid-induced mitochondrial fragmentation was independent of the fatty acid chain saturation and required dynamin-related protein 1 (DRP1).	Fatty Acids	0-10	dynamin 1 like	Homo sapiens	111-136
29110115-6	2018	Mutation of DNM1L was also associated with impaired responses to oxidative stress, as treatment with hydrogen peroxide dramatically increased cellular ROS, with minimal exacerbation of already impaired mitochondrial function.	Reactive Oxygen Species	151-154	dynamin 1 like	Homo sapiens	12-17
29360568-7	2018	Fatty acid-induced mitochondrial fragmentation was independent of the fatty acid chain saturation and required dynamin-related protein 1 (DRP1).	Fatty Acids	0-10	dynamin 1 like	Homo sapiens	138-142
29360568-11	2018	Pharmacological or genetic inhibition of DRP1 enhanced palmitate-induced mitochondrial ROS production, c-Jun phosphorylation, and inflammatory cytokine expression.	Palmitates	55-64	dynamin 1 like	Homo sapiens	41-45
29360568-11	2018	Pharmacological or genetic inhibition of DRP1 enhanced palmitate-induced mitochondrial ROS production, c-Jun phosphorylation, and inflammatory cytokine expression.	ros	87-90	dynamin 1 like	Homo sapiens	41-45
29314417-7	2018	Inhibition of Cdk5 using RNAi or a chemical inhibitor (roscovitine) induces mitochondrial elongation and promotes mitochondrial respiration, indicating that Cdk5-dependent Drp1 phosphorylation participates in mitochondrial metabolism and NSPC stemness regulation.	Roscovitine	55-66	dynamin 1 like	Homo sapiens	172-176
29620184-0	2018	Zearalenone regulates endometrial stromal cell apoptosis and migration via the promotion of mitochondrial fission by activation of the JNK/Drp1 pathway.	Zearalenone	0-11	dynamin 1 like	Homo sapiens	139-143
29620184-8	2018	ZEA also increased JNK phosphorylation and subsequently Drp1 phosphorylation at the serine 616 position, resulting in Drp1 activation.	Serine	84-90	dynamin 1 like	Homo sapiens	56-60
29478834-4	2018	Genetic or pharmacological abrogation of DRP1 activity abolished circadian network dynamics and mitochondrial respiratory activity and eliminated circadian ATP production.	Adenosine Triphosphate	156-159	dynamin 1 like	Homo sapiens	41-45
29391262-7	2018	Treatment of epithelial cells with QUE inhibited CSE-induced mitochondrial dysfunction and mitophagy by inhibiting phospho (p)-DRP-1 and PINK1 expression.	quercetagetin	35-38	dynamin 1 like	Homo sapiens	127-132
30566949-10	2018	CONCLUSION: Glomerular overproduction of Drp1, phospho-Drp1 (Ser 616) and Fis1 occurred mainly in children with membranous nephropathy.	Serine	61-64	dynamin 1 like	Homo sapiens	55-59
29217195-0	2018	Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Serine	170-176	dynamin 1 like	Homo sapiens	134-159
29217195-0	2018	Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.	Serine	170-176	dynamin 1 like	Homo sapiens	161-165
29217195-4	2018	First, we found that X-irradiation triggered Drp1 phosphorylation at serine 616 (S616) but not at serine 637 (S637).	Serine	69-75	dynamin 1 like	Homo sapiens	45-49
29183837-0	2018	Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression.	Melatonin	0-9	dynamin 1 like	Homo sapiens	81-106
29183837-0	2018	Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression.	Rotenone	19-27	dynamin 1 like	Homo sapiens	81-106
29183837-7	2018	The viability and expression levels of Cyt C and LC3 B in rotenone and melatonin + rotenone-treated Drp1-overexpressed SH-SY5Y cells were analyzed with MTS and western blotting, respectively.	Rotenone	83-91	dynamin 1 like	Homo sapiens	100-104
29183837-9	2018	Drp1 expression and its regulation of mitochondrial translocation mediated the rotenone-induced cell death and melatonin inhibited this process.	Rotenone	79-87	dynamin 1 like	Homo sapiens	0-4
29183837-9	2018	Drp1 expression and its regulation of mitochondrial translocation mediated the rotenone-induced cell death and melatonin inhibited this process.	Melatonin	111-120	dynamin 1 like	Homo sapiens	0-4
29183837-10	2018	Overexpression of Drp1 protein attenuated melatonin"s inhibition of rotenone-induced SH-SY5Y cell death.	Melatonin	42-51	dynamin 1 like	Homo sapiens	18-22
29183837-10	2018	Overexpression of Drp1 protein attenuated melatonin"s inhibition of rotenone-induced SH-SY5Y cell death.	Rotenone	68-76	dynamin 1 like	Homo sapiens	18-22
29183837-11	2018	In conclusion, melatonin effectively inhibits rotenone-induced neuronal cell death via the regulation of Drp1 expression.	Melatonin	15-24	dynamin 1 like	Homo sapiens	105-109
29183837-11	2018	In conclusion, melatonin effectively inhibits rotenone-induced neuronal cell death via the regulation of Drp1 expression.	Rotenone	46-54	dynamin 1 like	Homo sapiens	105-109
30029585-5	2018	In a recent study, we demonstrated that S-nitrosylation, the reversible modification of cysteine residues by nitric oxide (NO), hyperactivates mitochondrial fragmentation by targeting DNM1L/Drp1 (dynamin 1-like) at Cys644, but inhibits mitophagy, the concomitant occurrence of these conditions driving cell senescence.	Cysteine	88-96	dynamin 1 like	Homo sapiens	184-189
30029585-5	2018	In a recent study, we demonstrated that S-nitrosylation, the reversible modification of cysteine residues by nitric oxide (NO), hyperactivates mitochondrial fragmentation by targeting DNM1L/Drp1 (dynamin 1-like) at Cys644, but inhibits mitophagy, the concomitant occurrence of these conditions driving cell senescence.	Cysteine	88-96	dynamin 1 like	Homo sapiens	190-194
30029585-5	2018	In a recent study, we demonstrated that S-nitrosylation, the reversible modification of cysteine residues by nitric oxide (NO), hyperactivates mitochondrial fragmentation by targeting DNM1L/Drp1 (dynamin 1-like) at Cys644, but inhibits mitophagy, the concomitant occurrence of these conditions driving cell senescence.	Nitric Oxide	109-121	dynamin 1 like	Homo sapiens	184-189
30029585-5	2018	In a recent study, we demonstrated that S-nitrosylation, the reversible modification of cysteine residues by nitric oxide (NO), hyperactivates mitochondrial fragmentation by targeting DNM1L/Drp1 (dynamin 1-like) at Cys644, but inhibits mitophagy, the concomitant occurrence of these conditions driving cell senescence.	Nitric Oxide	109-121	dynamin 1 like	Homo sapiens	190-194
29022905-4	2017	In this study, we found that c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation.	Tyrosine	58-66	dynamin 1 like	Homo sapiens	50-54
29268097-0	2017	Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence.	Cocaine	98-105	dynamin 1 like	Homo sapiens	0-4
29268097-2	2017	We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals.	Cocaine	142-149	dynamin 1 like	Homo sapiens	30-55
29268097-2	2017	We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals.	Cocaine	142-149	dynamin 1 like	Homo sapiens	57-61
29268097-2	2017	We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals.	Cocaine	166-173	dynamin 1 like	Homo sapiens	30-55
29268097-2	2017	We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals.	Cocaine	166-173	dynamin 1 like	Homo sapiens	57-61
29268097-5	2017	Knockdown of Drp1 in D1-MSNs blocks drug seeking after cocaine self-administration, while enhancing the fission promoting Drp1 enhances seeking after long-term abstinence from cocaine.	Cocaine	55-62	dynamin 1 like	Homo sapiens	13-17
28818497-9	2017	The MEK inhibitor PD325901 suppressed cell proliferation, as well as inhibiting the phosphorylation of ERK1/2 and Drp1Ser616.	mirdametinib	18-26	dynamin 1 like	Homo sapiens	114-118
28842943-5	2017	mdivi-1 is a quinazolinone originally described as a selective inhibitor of Drp1, over other dynamin family members, and reported to inhibit mitochondrial fission.	Quinazolinones	13-26	dynamin 1 like	Homo sapiens	76-80
28729291-3	2017	Although nigericin-induced mitochondria fission was rescued by knockdown of either dynamin-related protein 1 or TBC1 domain family member 15 (TBC1D15), which are two distinct mitochondria fission regulators, only TBC1D15 restored the activity of the STING pathway, which indicates that inflammasome-activating signals curtail STING pathway activation via TBC1D15.	Nigericin	9-18	dynamin 1 like	Homo sapiens	83-108
28838842-5	2017	The dynamin related fission protein Drp-1 was phosphorylated (Drp1616) and coincided with excessive mitochondrial fragmentation, mitophagy and necrosis in cardiac myocytes treated with doxorubicin or subjected to hypoxia.	Doxorubicin	185-196	dynamin 1 like	Homo sapiens	36-41
29022905-4	2017	In this study, we found that c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation.	Tyrosine	58-66	dynamin 1 like	Homo sapiens	145-149
29022905-4	2017	In this study, we found that c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation.	Tyrosine	58-66	dynamin 1 like	Homo sapiens	145-149
28981113-3	2017	Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission that oligomerizes at the mitochondrial outer membrane and hydrolyzes GTP to drive mitochondrial fragmentation.	Guanosine Triphosphate	146-149	dynamin 1 like	Homo sapiens	0-25
28981113-3	2017	Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission that oligomerizes at the mitochondrial outer membrane and hydrolyzes GTP to drive mitochondrial fragmentation.	Guanosine Triphosphate	146-149	dynamin 1 like	Homo sapiens	27-31
28878368-5	2017	These Drp1 polymers assemble exclusively through stalk and G-domain dimerizations, which generates an expanded helical symmetry when compared to other dynamins.	Polymers	11-19	dynamin 1 like	Homo sapiens	6-10
28672961-7	2017	The results of the present study indicate that Salidroside and Mdivi-1 inhibit VSMC proliferation, Drp1 expression and oxidative stress and upregulate Mfn2 expression (all P&lt;0.05).	rhodioloside	47-58	dynamin 1 like	Homo sapiens	99-103
28552593-0	2017	Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission.	tyrphostin A9	0-13	dynamin 1 like	Homo sapiens	86-111
28500249-7	2017	The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels.	4-phenylbutyric acid	22-39	dynamin 1 like	Homo sapiens	427-432
28500249-7	2017	The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels.	4-phenylbutyric acid	41-44	dynamin 1 like	Homo sapiens	427-432
28552593-3	2017	Here, we investigated the effect of Drp1-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, tyrphostin A9 (TA9).	tyrphostin A9	162-175	dynamin 1 like	Homo sapiens	36-40
28632757-4	2017	Self-assembly of DRP1 into oligomers in a GTP-dependent manner likely drives the division process.	Guanosine Triphosphate	42-45	dynamin 1 like	Homo sapiens	17-21
28632757-5	2017	We show here that DRP1 self-assembles in two ways: i) in the presence of the non-hydrolysable GTP analog GMP-PNP into spiral-like structures of ~36 nm diameter; and ii) in the presence of GTP into rings composed of 13-18 monomers.	Guanosine Triphosphate	94-97	dynamin 1 like	Homo sapiens	18-22
28632757-5	2017	We show here that DRP1 self-assembles in two ways: i) in the presence of the non-hydrolysable GTP analog GMP-PNP into spiral-like structures of ~36 nm diameter; and ii) in the presence of GTP into rings composed of 13-18 monomers.	Guanylyl Imidodiphosphate	105-112	dynamin 1 like	Homo sapiens	18-22
28632757-5	2017	We show here that DRP1 self-assembles in two ways: i) in the presence of the non-hydrolysable GTP analog GMP-PNP into spiral-like structures of ~36 nm diameter; and ii) in the presence of GTP into rings composed of 13-18 monomers.	Guanosine Triphosphate	188-191	dynamin 1 like	Homo sapiens	18-22
28273447-4	2017	Direct inhibition of Drp1 negated high-fat-feeding-induced mitochondrial fission, endoplasmic reticulum (ER) stress, and insulin resistance in the DVC and subsequently restored hepatic glucose production regulation.	Glucose	185-192	dynamin 1 like	Homo sapiens	21-25
28835909-4	2017	Mitochondrial membrane lipids such as phosphatidic acid and cardiolipin bind Drp1, and Drp1-phospholipid interactions provide key regulatory mechanisms for mitochondrial division (Montessuit et al., 2010; Bustillo-Zabalbeitia et al., 2014; Macdonald et al., 2014; Stepanyants et al., 2015; Adachi et al., 2016).	Phosphatidic Acids	38-55	dynamin 1 like	Homo sapiens	77-81
28835909-4	2017	Mitochondrial membrane lipids such as phosphatidic acid and cardiolipin bind Drp1, and Drp1-phospholipid interactions provide key regulatory mechanisms for mitochondrial division (Montessuit et al., 2010; Bustillo-Zabalbeitia et al., 2014; Macdonald et al., 2014; Stepanyants et al., 2015; Adachi et al., 2016).	Phospholipids	92-104	dynamin 1 like	Homo sapiens	87-91
28835909-5	2017	Here, we describe biochemical experiments that quantitatively measure interactions of Drp1 with lipids using purified recombinant Drp1 and synthetic liposomes with a defined set of phospholipids.	Phospholipids	181-194	dynamin 1 like	Homo sapiens	86-90
28423497-0	2017	Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function.	Cisplatin	42-51	dynamin 1 like	Homo sapiens	0-4
28423497-11	2017	Suppression of mitochondrial fission by knockdown of its main regulator dynamin-related protein-1 (Drp1) decreased cisplatin-induced mitophagy.	Cisplatin	115-124	dynamin 1 like	Homo sapiens	72-97
28423497-11	2017	Suppression of mitochondrial fission by knockdown of its main regulator dynamin-related protein-1 (Drp1) decreased cisplatin-induced mitophagy.	Cisplatin	115-124	dynamin 1 like	Homo sapiens	99-103
28423497-12	2017	Meanwhile, Drp1 suppression protected against cisplatin-induced cells injury by inhibiting mitochondrial dysfunction.	Cisplatin	46-55	dynamin 1 like	Homo sapiens	11-15
28423497-13	2017	Our results provide evidence that Drp1-depedent mitophagy has potential as renoprotective targets for the treatment of cisplatin-induced AKI.	Cisplatin	119-128	dynamin 1 like	Homo sapiens	34-38
28435473-7	2017	The underlying mechanism is that RSV suppresses mitochondrial COX-2, thereby reducing NPC stemness by inhibiting Drp1 activity as demonstrated in both the in vitro and the in vivo studies.	Resveratrol	33-36	dynamin 1 like	Homo sapiens	113-117
27923790-0	2017	Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles.	Glucose	39-46	dynamin 1 like	Homo sapiens	0-25
27923790-11	2017	Disruption of Drp1 and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of LG-induced endothelial dysfunction.NEW &amp; NOTEWORTHY Acute low-glucose exposure induces mitochondrial fragmentation in endothelial cells via Drp1 and is associated with impaired endothelial function in human arterioles.	Adenosine Monophosphate	242-245	dynamin 1 like	Homo sapiens	14-18
27923790-11	2017	Disruption of Drp1 and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of LG-induced endothelial dysfunction.NEW &amp; NOTEWORTHY Acute low-glucose exposure induces mitochondrial fragmentation in endothelial cells via Drp1 and is associated with impaired endothelial function in human arterioles.	Glucose	268-275	dynamin 1 like	Homo sapiens	14-18
27831567-8	2016	Consistent with this, the expression of S616-phosphorylated Drp1 recapitulated the mitochondrial dynamics, mitochondrial ROS levels, metabolic switching and chemoresistance seen in T-ALL cells cocultured with MSCs.	Reactive Oxygen Species	121-124	dynamin 1 like	Homo sapiens	60-64
28040727-4	2017	A highly conserved FLV motif was identified in the C-terminus of DLP1, mutation of which significantly reduced VPS35-DLP1 interaction.	naphthalene-1,2,4,5,7-pentol	19-22	dynamin 1 like	Homo sapiens	65-69
28040727-4	2017	A highly conserved FLV motif was identified in the C-terminus of DLP1, mutation of which significantly reduced VPS35-DLP1 interaction.	naphthalene-1,2,4,5,7-pentol	19-22	dynamin 1 like	Homo sapiens	117-121
28088331-0	2017	Eicosapentaenoic acid ameliorates palmitate-induced lipotoxicity via the AMP kinase/dynamin-related protein-1 signaling pathway in differentiated H9c2 myocytes.	Eicosapentaenoic Acid	0-21	dynamin 1 like	Homo sapiens	84-109
28088331-0	2017	Eicosapentaenoic acid ameliorates palmitate-induced lipotoxicity via the AMP kinase/dynamin-related protein-1 signaling pathway in differentiated H9c2 myocytes.	Palmitates	34-43	dynamin 1 like	Homo sapiens	84-109
28088331-3	2017	In this study, we focused on dynamin-related protein-1 (Drp1) as a possible modulator of the EPA-mediated cardiac protection against cardiac lipotoxicity, and investigated the causal relation between AMP-activated protein kinase (AMPK) and Drp1.	Eicosapentaenoic Acid	93-96	dynamin 1 like	Homo sapiens	29-54
28088331-3	2017	In this study, we focused on dynamin-related protein-1 (Drp1) as a possible modulator of the EPA-mediated cardiac protection against cardiac lipotoxicity, and investigated the causal relation between AMP-activated protein kinase (AMPK) and Drp1.	Eicosapentaenoic Acid	93-96	dynamin 1 like	Homo sapiens	56-60
28088331-7	2017	EPA (50microM) restored the PAL-induced apoptosis, mitochondrial dysfunction, and mitochondrial fragmentation with increased Drp1 expression by PAL.	Eicosapentaenoic Acid	0-3	dynamin 1 like	Homo sapiens	125-129
28088331-8	2017	EPA activated phosphorylation of AMPK, and pharmacological activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide ameliorated the PAL-induced apoptosis, mitochondrial dysfunction, and downregulated Drp1.	Eicosapentaenoic Acid	0-3	dynamin 1 like	Homo sapiens	211-215
28088331-8	2017	EPA activated phosphorylation of AMPK, and pharmacological activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide ameliorated the PAL-induced apoptosis, mitochondrial dysfunction, and downregulated Drp1.	AICA ribonucleotide	81-126	dynamin 1 like	Homo sapiens	211-215
28088331-10	2017	CONCLUSION: EPA ameliorates the PAL-induced lipotoxicity via AMPK activation, which subsequently suppresses mitochondrial fragmentation and Drp1 expression.	Eicosapentaenoic Acid	12-15	dynamin 1 like	Homo sapiens	140-144
28088331-10	2017	CONCLUSION: EPA ameliorates the PAL-induced lipotoxicity via AMPK activation, which subsequently suppresses mitochondrial fragmentation and Drp1 expression.	Palmitates	32-35	dynamin 1 like	Homo sapiens	140-144
27799292-6	2017	Interestingly, caspase-10, but not caspase-8, formed a ternary protein complex with SUMO-FADD/Drp1 on the mitochondria upon exposure to A23187 and potentiated Drp1 oligomerization for necrosis.	Calcimycin	136-142	dynamin 1 like	Homo sapiens	94-98
27799292-8	2017	Our study reveals an essential role of SUMOylated FADD in Drp1- and caspase-10-dependent necrosis, providing insights into the mechanism of regulated necrosis by calcium overload and ischemic injury.	Calcium	162-169	dynamin 1 like	Homo sapiens	58-62
27660309-10	2016	We speculate that endogenous MiDs serve as Drp1-binding partners that are dysregulated in disease states and may be important targets for inhibiting cell proliferation and ischemia/reperfusion injury.	mids	29-33	dynamin 1 like	Homo sapiens	43-47
27635761-0	2016	Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division.	Phosphatidic Acids	11-28	dynamin 1 like	Homo sapiens	51-55
27739424-4	2016	Mechanistically, this effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1 (Drp1), by Ca2+/calmodulin-dependent kinase II (CaMKII) at a serine 616 (S616) site.	Serine	181-187	dynamin 1 like	Homo sapiens	94-119
27739424-4	2016	Mechanistically, this effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1 (Drp1), by Ca2+/calmodulin-dependent kinase II (CaMKII) at a serine 616 (S616) site.	Serine	181-187	dynamin 1 like	Homo sapiens	121-125
27559132-6	2016	GDP and GTP accelerate and decelerate Drp1/actin binding dynamics, respectively.	Guanosine Diphosphate	0-3	dynamin 1 like	Homo sapiens	38-42
27559132-6	2016	GDP and GTP accelerate and decelerate Drp1/actin binding dynamics, respectively.	Guanosine Triphosphate	8-11	dynamin 1 like	Homo sapiens	38-42
27559132-7	2016	Actin has a biphasic effect on Drp1 GTP hydrolysis, increasing at low actin:Drp1 ratio but returning to baseline at high ratio.	Guanosine Triphosphate	36-39	dynamin 1 like	Homo sapiens	31-35
27559132-7	2016	Actin has a biphasic effect on Drp1 GTP hydrolysis, increasing at low actin:Drp1 ratio but returning to baseline at high ratio.	Guanosine Triphosphate	36-39	dynamin 1 like	Homo sapiens	76-80
27540013-6	2016	Mitochondrial ceramide accumulation and lethal mitophagy induction in response to FLT3-ITD targeting was mediated by dynamin-related protein 1 (Drp1) activation via inhibition of protein kinase A-regulated S637 phosphorylation, resulting in mitochondrial fission.	Ceramides	14-22	dynamin 1 like	Homo sapiens	117-142
27540013-6	2016	Mitochondrial ceramide accumulation and lethal mitophagy induction in response to FLT3-ITD targeting was mediated by dynamin-related protein 1 (Drp1) activation via inhibition of protein kinase A-regulated S637 phosphorylation, resulting in mitochondrial fission.	Ceramides	14-22	dynamin 1 like	Homo sapiens	144-148
27540013-7	2016	Inhibition of Drp1 prevented ceramide-dependent lethal mitophagy, and reconstitution of WT-Drp1 or phospho-null S637A-Drp1 but not its inactive phospho-mimic mutant (S637D-Drp1), restored mitochondrial fission and mitophagy in response to crenolanib in FLT3-ITD+ AML cells expressing stable shRNA against endogenous Drp1.	Ceramides	29-37	dynamin 1 like	Homo sapiens	14-18
27540013-7	2016	Inhibition of Drp1 prevented ceramide-dependent lethal mitophagy, and reconstitution of WT-Drp1 or phospho-null S637A-Drp1 but not its inactive phospho-mimic mutant (S637D-Drp1), restored mitochondrial fission and mitophagy in response to crenolanib in FLT3-ITD+ AML cells expressing stable shRNA against endogenous Drp1.	crenolanib	239-249	dynamin 1 like	Homo sapiens	14-18
27635761-4	2016	Here, we report an unforeseen mechanism that regulates mitochondrial division by coincident interactions of Drp1 with the head group and acyl chains of phospholipids.	Phospholipids	152-165	dynamin 1 like	Homo sapiens	108-112
27635761-5	2016	Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of another phospholipid by penetrating into the hydrophobic core of the membrane.	Phosphatidic Acids	34-51	dynamin 1 like	Homo sapiens	0-4
27635761-5	2016	Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of another phospholipid by penetrating into the hydrophobic core of the membrane.	Phosphatidic Acids	53-55	dynamin 1 like	Homo sapiens	0-4
27635761-5	2016	Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of another phospholipid by penetrating into the hydrophobic core of the membrane.	Phospholipids	98-110	dynamin 1 like	Homo sapiens	0-4
27635761-6	2016	The dual phospholipid interactions restrain Drp1 via inhibition of oligomerization-stimulated GTP hydrolysis that promotes membrane constriction.	Phospholipids	9-21	dynamin 1 like	Homo sapiens	44-48
27635761-6	2016	The dual phospholipid interactions restrain Drp1 via inhibition of oligomerization-stimulated GTP hydrolysis that promotes membrane constriction.	Guanosine Triphosphate	94-97	dynamin 1 like	Homo sapiens	44-48
27635761-7	2016	Moreover, a PA-producing phospholipase, MitoPLD, binds Drp1, creating a PA-rich microenvironment in the vicinity of a division apparatus.	Phosphatidic Acids	12-14	dynamin 1 like	Homo sapiens	55-59
27635761-7	2016	Moreover, a PA-producing phospholipase, MitoPLD, binds Drp1, creating a PA-rich microenvironment in the vicinity of a division apparatus.	Phosphatidic Acids	72-74	dynamin 1 like	Homo sapiens	55-59
27635761-8	2016	Thus, PA controls the activation of Drp1 after the formation of the division apparatus.	Phosphatidic Acids	6-8	dynamin 1 like	Homo sapiens	36-40
26903301-6	2016	Increased ROS levels induced excessive mitochondrial fission through dynamin-related protein (Drp 1), while Mdivi-1 suppressed the sensitivity of Drp1 to ROS levels, thus inhibiting excessive mitochondrial fission under high-glucose conditions.	Reactive Oxygen Species	10-13	dynamin 1 like	Homo sapiens	94-99
27010815-0	2016	Reactive oxygen species effect PASMCs apoptosis via regulation of dynamin-related protein 1 in hypoxic pulmonary hypertension.	Reactive Oxygen Species	0-23	dynamin 1 like	Homo sapiens	66-91
27010815-0	2016	Reactive oxygen species effect PASMCs apoptosis via regulation of dynamin-related protein 1 in hypoxic pulmonary hypertension.	pasmcs	31-37	dynamin 1 like	Homo sapiens	66-91
27010815-2	2016	However, the regulatory mechanisms between ROS and DRP1 are poorly understood.	Reactive Oxygen Species	43-46	dynamin 1 like	Homo sapiens	51-55
27010815-5	2016	Meanwhile, we also observed that hypoxia-induced DRP1 expression depends on ROS generation, especially mitochondrial ROS (mROS).	Reactive Oxygen Species	76-79	dynamin 1 like	Homo sapiens	49-53
27010815-5	2016	Meanwhile, we also observed that hypoxia-induced DRP1 expression depends on ROS generation, especially mitochondrial ROS (mROS).	Reactive Oxygen Species	117-120	dynamin 1 like	Homo sapiens	49-53
27010815-6	2016	Moreover, the levels of ROS and mROS evoked by hypoxia were regulated by DRP1.	Reactive Oxygen Species	24-27	dynamin 1 like	Homo sapiens	73-77
27010815-7	2016	Furthermore, we verified the apoptosis suppression of PASMCs under hypoxia due to the interaction between ROS/mROS and DRP1.	pasmcs	54-60	dynamin 1 like	Homo sapiens	119-123
27010815-8	2016	Our study reveals a novel mechanism of hypoxia-induced pulmonary vascular remodeling, suggesting a new therapeutic strategy which is targeting on the positive feedback of ROS/mROS-DRP1 for the treatment of PAH.	Reactive Oxygen Species	171-174	dynamin 1 like	Homo sapiens	180-184
27010815-8	2016	Our study reveals a novel mechanism of hypoxia-induced pulmonary vascular remodeling, suggesting a new therapeutic strategy which is targeting on the positive feedback of ROS/mROS-DRP1 for the treatment of PAH.	p-Aminohippuric Acid	206-209	dynamin 1 like	Homo sapiens	180-184
27027430-0	2016	Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death.	ros	76-79	dynamin 1 like	Homo sapiens	90-94
26604000-2	2016	In dividing mitochondria, membrane scission is accomplished by a dynamin-related GTPase, DNM1L, that oligomerizes at the site of fission and constricts in a GTP-dependent manner.	Guanosine Triphosphate	81-84	dynamin 1 like	Homo sapiens	89-94
26604000-3	2016	There is only a single previous report of DNM1L-related clinical disease: a female neonate with encephalopathy due to defective mitochondrial and peroxisomal fission (EMPF; OMIM #614388), a lethal disorder characterized by cerebral dysgenesis, seizures, lactic acidosis, elevated very long chain fatty acids, and abnormally elongated mitochondria and peroxisomes.	chain fatty acids	290-307	dynamin 1 like	Homo sapiens	42-47
26604000-3	2016	There is only a single previous report of DNM1L-related clinical disease: a female neonate with encephalopathy due to defective mitochondrial and peroxisomal fission (EMPF; OMIM #614388), a lethal disorder characterized by cerebral dysgenesis, seizures, lactic acidosis, elevated very long chain fatty acids, and abnormally elongated mitochondria and peroxisomes.	chain fatty acids	290-307	dynamin 1 like	Homo sapiens	167-171
27076521-6	2016	Using a proximity-based biotin labeling approach, we found close associations between MiD51, Mff and Drp1, but not Fis1.	Biotin	24-30	dynamin 1 like	Homo sapiens	101-105
26878937-5	2016	Furthermore, we demonstrated visible light control of mitochondrial fragmentation via activation of dynamin-related protein 1 (Drp1) by means of precisely controlled NO delivery into mitochondria of cultured HEK293 cells, utilizing Rol-DNB-pyr.	rol-dnb-pyr	232-243	dynamin 1 like	Homo sapiens	100-125
26878937-5	2016	Furthermore, we demonstrated visible light control of mitochondrial fragmentation via activation of dynamin-related protein 1 (Drp1) by means of precisely controlled NO delivery into mitochondria of cultured HEK293 cells, utilizing Rol-DNB-pyr.	rol-dnb-pyr	232-243	dynamin 1 like	Homo sapiens	127-131
26991754-10	2016	Elevated glucose conditions (11 and 25 mM) significantly increased ROS generation, whereas only the 25-mM high glucose condition induced mitochondrial fission and increased the expression of activated dynamin-related protein 1 in iPSC-CMs.	Glucose	111-118	dynamin 1 like	Homo sapiens	201-226
26602979-9	2016	Improvement of LPS-induced mitochondrial dysfunction by fasudil was attributed to inhibition of ROCK-dependent Drp1 phosphorylation and activation of autophagic processes that can limit mitochondrial fragmentation and enhance degradation of damaged mitochondria, respectively.	fasudil	56-63	dynamin 1 like	Homo sapiens	111-115
26903301-6	2016	Increased ROS levels induced excessive mitochondrial fission through dynamin-related protein (Drp 1), while Mdivi-1 suppressed the sensitivity of Drp1 to ROS levels, thus inhibiting excessive mitochondrial fission under high-glucose conditions.	Reactive Oxygen Species	154-157	dynamin 1 like	Homo sapiens	146-150
26903301-6	2016	Increased ROS levels induced excessive mitochondrial fission through dynamin-related protein (Drp 1), while Mdivi-1 suppressed the sensitivity of Drp1 to ROS levels, thus inhibiting excessive mitochondrial fission under high-glucose conditions.	Glucose	225-232	dynamin 1 like	Homo sapiens	146-150
26919426-3	2016	Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).	Glucose	19-26	dynamin 1 like	Homo sapiens	128-153
26919426-3	2016	Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).	Glucose	19-26	dynamin 1 like	Homo sapiens	155-159
26919426-3	2016	Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).	Reactive Oxygen Species	77-100	dynamin 1 like	Homo sapiens	128-153
26919426-3	2016	Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).	Reactive Oxygen Species	77-100	dynamin 1 like	Homo sapiens	155-159
26446846-1	2015	Dynamin-related protein 1 (Drp1) is the GTP-hydrolyzing mechanoenzyme that catalyzes mitochondrial fission in the cell.	Guanosine Triphosphate	40-43	dynamin 1 like	Homo sapiens	0-25
27050458-5	2016	Mitochondrial stress such as selenite or FCCP treatment caused the disassembly of the FUNDC1-OPA1 complex while enhancing DNM1L recruitment to the mitochondria.	Selenious Acid	29-37	dynamin 1 like	Homo sapiens	122-127
27050458-5	2016	Mitochondrial stress such as selenite or FCCP treatment caused the disassembly of the FUNDC1-OPA1 complex while enhancing DNM1L recruitment to the mitochondria.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	41-45	dynamin 1 like	Homo sapiens	122-127
26432782-5	2016	In the present study, we reported that the phosphorylation status of Drp1-Ser(637) was essential for its interaction with Mff.	Serine	74-77	dynamin 1 like	Homo sapiens	69-73
26432782-6	2016	UV stimulation induced a decrease in cytoplasmic and mitochondrial Drp1 phosphorylation on Ser(637) and enhanced the interaction between Drp1 and Mff, resulting in mitochondrial fragmentation.	Serine	91-94	dynamin 1 like	Homo sapiens	67-71
26578513-8	2016	Moreover, the differential stimulatory effects of Mff on Drp1 isoforms are dependent on the mitochondrial lipid, cardiolipin (CL).	Cardiolipins	113-124	dynamin 1 like	Homo sapiens	57-61
26518267-11	2015	Interestingly, treatment with 3-NP induces subcellular translocation of hnRNP A1 from the nucleus to the cytoplasm, which accelerates the increase in Drp1 expression in hnRNP A1 over-expressing cells.	3-nitropropionic acid	30-34	dynamin 1 like	Homo sapiens	150-154
26446846-1	2015	Dynamin-related protein 1 (Drp1) is the GTP-hydrolyzing mechanoenzyme that catalyzes mitochondrial fission in the cell.	Guanosine Triphosphate	40-43	dynamin 1 like	Homo sapiens	27-31
26446846-2	2015	Residing in the cytosol as dimers and tetramers, Drp1 is recruited by receptors on the mitochondrial outer membrane, where it further assembles into a helical ring that drives division via GTP-dependent constriction.	Guanosine Triphosphate	189-192	dynamin 1 like	Homo sapiens	49-53
26598294-0	2015	Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells.	Chlorpyrifos	71-83	dynamin 1 like	Homo sapiens	0-25
26598294-2	2015	However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity.	Chlorpyrifos	94-106	dynamin 1 like	Homo sapiens	54-58
26598294-2	2015	However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity.	Chlorpyrifos	108-111	dynamin 1 like	Homo sapiens	54-58
26598294-3	2015	In this study, we determined that CPF-induced mitochondrial apoptosis is mediated by Drp1 translocation in SH-SY5Y human neuroblastoma cells.	Chlorpyrifos	34-37	dynamin 1 like	Homo sapiens	85-89
26598294-7	2015	Inhibiting this ROS generation and MAPK activation abolished CPF-induced expression of phospho-Drp1.	Reactive Oxygen Species	16-19	dynamin 1 like	Homo sapiens	95-99
26598294-11	2015	Taken together, these data reveal a novel mechanism by which Drp1 activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 function can protect against CPF-induced cytotoxicity.	Chlorpyrifos	173-176	dynamin 1 like	Homo sapiens	61-65
26609810-6	2015	Ionomycin, a calcium ionophore, causes rapid mitochondrial accumulation of actin filaments followed by Drp1 accumulation at the fission site, and increases fission rate.	Ionomycin	0-9	dynamin 1 like	Homo sapiens	103-107
26609810-6	2015	Ionomycin, a calcium ionophore, causes rapid mitochondrial accumulation of actin filaments followed by Drp1 accumulation at the fission site, and increases fission rate.	Calcium	13-20	dynamin 1 like	Homo sapiens	103-107
26609810-7	2015	Inhibiting actin polymerization, myosin IIA, or the formin INF2 reduces both un-stimulated and ionomycin-induced Drp1 accumulation and mitochondrial fission.	Ionomycin	95-104	dynamin 1 like	Homo sapiens	113-117
26352374-8	2015	RESULTS: Exposure to 6 h of 20 mug/ml propofol increased cell death from 3.18 +- 0.17% in the control-treated group to 9.6 +- 0.95% and led to detrimental increases in mitochondrial fission (n = 5 coverslips per group) accompanied by increased expression of activated dynamin-related protein 1 and cyclin-dependent kinase 1, key proteins responsible for mitochondrial fission.	Propofol	38-46	dynamin 1 like	Homo sapiens	268-293
26622184-0	2015	Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death.	micheliolide	41-53	dynamin 1 like	Homo sapiens	0-25
26622184-7	2015	Furthermore, mitochondrial membrane potential decreased, whereas reactive oxygen species (ROS) generation, cytochrome c release, and PARP cleavage were enhanced after overexpression of Drp1 wild type.	Reactive Oxygen Species	65-88	dynamin 1 like	Homo sapiens	185-189
26622184-7	2015	Furthermore, mitochondrial membrane potential decreased, whereas reactive oxygen species (ROS) generation, cytochrome c release, and PARP cleavage were enhanced after overexpression of Drp1 wild type.	Reactive Oxygen Species	90-93	dynamin 1 like	Homo sapiens	185-189
26622184-9	2015	Finally, MCL-induced Drp1-mediated cell death could be reversed by N-acetyl-L-cysteine (the ROS scavenger) in breast cancer cells.	Acetylcysteine	67-86	dynamin 1 like	Homo sapiens	21-25
26622184-9	2015	Finally, MCL-induced Drp1-mediated cell death could be reversed by N-acetyl-L-cysteine (the ROS scavenger) in breast cancer cells.	Reactive Oxygen Species	92-95	dynamin 1 like	Homo sapiens	21-25
26622184-10	2015	Taken together, the present study shows a novel role for Drp1 in MCL-induced breast cancer cell death, potentially through regulation of ROS-mitochondrial apoptotic pathway.	Reactive Oxygen Species	137-140	dynamin 1 like	Homo sapiens	57-61
26514444-7	2015	Because Drp1 blocking also impaired the mitochondrial membrane potential, we tested whether supplementing with L-carnitine, a compound that restores mitochondrial membrane potential and ATP synthesis, could revert the defects induced by Drp1 inhibition.	Carnitine	111-122	dynamin 1 like	Homo sapiens	8-12
26514444-7	2015	Because Drp1 blocking also impaired the mitochondrial membrane potential, we tested whether supplementing with L-carnitine, a compound that restores mitochondrial membrane potential and ATP synthesis, could revert the defects induced by Drp1 inhibition.	Carnitine	111-122	dynamin 1 like	Homo sapiens	237-241
26514444-9	2015	These results suggest that Drp1 is required for functionally active mitochondria, and supplementing with ATP can restore the defects induced by Drp1 suppression.	Adenosine Triphosphate	105-108	dynamin 1 like	Homo sapiens	144-148
26306039-6	2015	Moreover, depletion of DAP3 dramatically decreases the phosphorylation of Drp1 at Ser-637 on mitochondria, enhancing the retention time of Drp1 puncta on mitochondria during the fission process.	Serine	82-85	dynamin 1 like	Homo sapiens	74-78
25993908-11	2015	Moreover, treatment of megakaryocytes with metformin enhanced mitochondrial content and in the same cells metformin enhanced the phosphorylation of the Drp-1 on Ser637 via an AMPKalpha1-dependent mechanism.	Metformin	43-52	dynamin 1 like	Homo sapiens	152-157
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	49-53
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	94-98
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	94-98
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	94-98
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	94-98
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	72-78	dynamin 1 like	Homo sapiens	94-98
26122121-5	2015	All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase.	Serine	212-218	dynamin 1 like	Homo sapiens	49-53
26122121-8	2015	Taken together, these findings implicate STAT2 as a novel regulator of DRP1 phosphorylation at serine 616, and thus of mitochondrial fission, and suggest that there are interactions between immunity and mitochondria.	Serine	95-101	dynamin 1 like	Homo sapiens	71-75
25752284-8	2015	Moreover, pulmonary vascular angiogenesis promoted by DRP1 was reversed by the specific mitochondrial Ca(2+) uniporter inhibitor Ru360.	Ru 360	129-134	dynamin 1 like	Homo sapiens	54-58
25752284-10	2015	Besides, DRP1 decreased mitochondrial membrane potential, reduced the DNA fragmentation, and inhibited the caspase-3 activation, which were all aggravated by Ru360.	Ru 360	158-163	dynamin 1 like	Homo sapiens	9-13
26438559-7	2015	In addition, BQ788 alleviated up-regulation of Rho kinase 1 (ROCK1) expression and impairment of DRP1-mediated mitochondrial fission in CA1 neurons following SE.	BQ 788	13-18	dynamin 1 like	Homo sapiens	97-101
26119034-0	2015	Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission.	astaxanthine	0-11	dynamin 1 like	Homo sapiens	90-94
26119034-2	2015	This study investigated the antifibrotic effect of astaxanthin on the promotion of myofibroblast apoptosis based on dynamin-related protein-1 (Drp1)-mediated mitochondrial fission in vivo and in vitro.	astaxanthine	51-62	dynamin 1 like	Homo sapiens	116-141
26119034-4	2015	Astaxanthin demonstrated pro-apoptotic function in myofibroblasts by contributing to mitochondrial fission, thereby leading to apoptosis by increasing the Drp1 expression and enhancing Drp1 translocation into the mitochondria.	astaxanthine	0-11	dynamin 1 like	Homo sapiens	155-159
26119034-4	2015	Astaxanthin demonstrated pro-apoptotic function in myofibroblasts by contributing to mitochondrial fission, thereby leading to apoptosis by increasing the Drp1 expression and enhancing Drp1 translocation into the mitochondria.	astaxanthine	0-11	dynamin 1 like	Homo sapiens	185-189
26119034-5	2015	Two specific siRNAs were used to demonstrate that Drp1 is necessary to promote astaxanthin-induced mitochondrial fission and apoptosis in myofibroblasts.	astaxanthine	79-90	dynamin 1 like	Homo sapiens	50-54
26119034-6	2015	Drp1-associated genes, such as Bcl-2-associated X protein, cytochrome c, tumour suppressor gene p53 and p53-up-regulated modulator of apoptosis, were highly up-regulated in the astaxanthin group compared with those in the sham group.	astaxanthine	177-188	dynamin 1 like	Homo sapiens	0-4
26119034-7	2015	This study revealed that astaxanthin can prevent pulmonary fibrosis by promoting myofibroblast apoptosis through a Drp1-dependent molecular pathway.	astaxanthine	25-36	dynamin 1 like	Homo sapiens	115-119
25993908-11	2015	Moreover, treatment of megakaryocytes with metformin enhanced mitochondrial content and in the same cells metformin enhanced the phosphorylation of the Drp-1 on Ser637 via an AMPKalpha1-dependent mechanism.	Metformin	106-115	dynamin 1 like	Homo sapiens	152-157
26002103-2	2015	Here, we report that the cytoplasmic CDK5 tightly regulates mitochondrial morphology defects associated with NMDA-induced neuronal injury via regulation of the mitochondrial fission protein, dynamin-related protein 1 (DRP1).	N-Methylaspartate	109-113	dynamin 1 like	Homo sapiens	191-216
26002103-2	2015	Here, we report that the cytoplasmic CDK5 tightly regulates mitochondrial morphology defects associated with NMDA-induced neuronal injury via regulation of the mitochondrial fission protein, dynamin-related protein 1 (DRP1).	N-Methylaspartate	109-113	dynamin 1 like	Homo sapiens	218-222
26002103-4	2015	CDK5-mediated phosphorylation of DRP1 at a conserved Serine residue, S585, is elevated at the mitochondria and is associated with increased mitochondrial fission.	Serine	53-59	dynamin 1 like	Homo sapiens	33-37
26002103-7	2015	In addition, pharmacological inhibition of CDK5 by Roscovitine inhibits DRP1 phosphorylation and mitochondrial fission associated with NMDA-induced neuronal loss.	Roscovitine	51-62	dynamin 1 like	Homo sapiens	72-76
26002103-8	2015	Importantly, conditional deletion of CDK5 significantly attenuates DRP1 phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.	N-Methylaspartate	160-164	dynamin 1 like	Homo sapiens	67-71
25482923-3	2015	In support of this conclusion, we show that Dlp1 knockdown dramatically affects mitochondrial morphological characteristics and localization in astrocytes, impairs the ability of astrocytes to adequately protect neurons from the excitotoxic effects of glutamate, and increases intracellular Ca(2+) in response to extracellular glutamate, resulting from compromised intracellular Ca(2+) buffering.	Glutamic Acid	252-261	dynamin 1 like	Homo sapiens	44-48
25857570-6	2015	DRP1 expression has increased significantly in glomerular mesangial cell (GMC), which is cultivated in high glucose (HG).	Glucose	108-115	dynamin 1 like	Homo sapiens	0-4
25857570-9	2015	Compared to the control groups ofNG and mannitol, overexpression of DRP1 destroyed pathological changes typical of the GMC, like accumulation of extracellular matrix, and an increase in mitochondria division.	Mannitol	40-48	dynamin 1 like	Homo sapiens	68-72
25857570-10	2015	In addition, Overexpression of DRP1 promoted the activation of p38, the accumulation of ROS, mitochondrial dysfunction, and the synthesis of collagen IV, and all these changes are suppressed by Midivi-1.	ros	88-91	dynamin 1 like	Homo sapiens	31-35
25770210-5	2015	Here, using time-resolved EM and rigorous statistical analyses, we establish the ability of full-length Drp1 to constrict lipid bilayers through a GTP hydrolysis-dependent mechanism.	Lipid Bilayers	122-136	dynamin 1 like	Homo sapiens	104-108
25770210-5	2015	Here, using time-resolved EM and rigorous statistical analyses, we establish the ability of full-length Drp1 to constrict lipid bilayers through a GTP hydrolysis-dependent mechanism.	Guanosine Triphosphate	147-150	dynamin 1 like	Homo sapiens	104-108
25770210-7	2015	Furthermore, the mechanochemical core of Drp1, absent of the variable domain, is sufficient to mediate GTP hydrolysis-dependent membrane constriction.	Guanosine Triphosphate	103-106	dynamin 1 like	Homo sapiens	41-45
25874011-11	2015	The clinical significance of this mechanism has already been highlighted by the finding that the kinase inhibitor tyrphostin A9 induces cancer cell death by DLP1-mediated mitochondrial fragmentation.	tyrphostin A9	114-127	dynamin 1 like	Homo sapiens	157-161
25581164-1	2015	Mitochondrial fission requires recruitment of dynamin-related protein 1 (Drp1) to the mitochondrial surface, where assembly leads to activation of its GTP-dependent scission function.	Guanosine Triphosphate	151-154	dynamin 1 like	Homo sapiens	46-71
25581164-1	2015	Mitochondrial fission requires recruitment of dynamin-related protein 1 (Drp1) to the mitochondrial surface, where assembly leads to activation of its GTP-dependent scission function.	Guanosine Triphosphate	151-154	dynamin 1 like	Homo sapiens	73-77
25658204-5	2015	These phenotypes are mechanistically linked by ERK1/2 phosphorylation of DRP1 serine 616; DRP1(S616) phosphorylation is sufficient to phenocopy transformation-induced mitochondrial dysfunction, and DRP1(S616) phosphorylation status dichotomizes BRAF(WT) from BRAF(V600E)-positive lesions.	Serine	78-84	dynamin 1 like	Homo sapiens	73-77
25730670-8	2015	DRP1 activation correlated with poor prognosis in glioblastoma, suggesting that mitochondrial dynamics may represent a therapeutic target for BTICs.	btics	142-147	dynamin 1 like	Homo sapiens	0-4
25482923-3	2015	In support of this conclusion, we show that Dlp1 knockdown dramatically affects mitochondrial morphological characteristics and localization in astrocytes, impairs the ability of astrocytes to adequately protect neurons from the excitotoxic effects of glutamate, and increases intracellular Ca(2+) in response to extracellular glutamate, resulting from compromised intracellular Ca(2+) buffering.	Glutamic Acid	327-336	dynamin 1 like	Homo sapiens	44-48
25482923-4	2015	Taken together, our results suggest that astrocytic mitochondrial Dlp1 is a key protein in mitochondrial dynamics and decreased Dlp1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.	Glutamic Acid	203-212	dynamin 1 like	Homo sapiens	66-70
25482923-4	2015	Taken together, our results suggest that astrocytic mitochondrial Dlp1 is a key protein in mitochondrial dynamics and decreased Dlp1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.	Glutamic Acid	203-212	dynamin 1 like	Homo sapiens	128-132
25592908-11	2015	Furthermore, the expression of Beclin1, LC3-II/LC3-I, Mfn2 and Drp1 was higher in the calcipotriol-treated melanocytes than in the control or H2O2-treated melanocytes.	calcipotriene	86-98	dynamin 1 like	Homo sapiens	63-67
25592908-13	2015	The expression of Mfn2 and Drp1 decreased with increasing calcipotriol concentration.	calcipotriene	58-70	dynamin 1 like	Homo sapiens	27-31
25595902-6	2015	Only dephosphorylated cofilin (Ser 3) and Drp1 (Ser 637) are translocated to the mitochondria.	Serine	48-51	dynamin 1 like	Homo sapiens	42-46
25322817-5	2015	While sustaining mitochondrial transport did not reduce axonal swellings in capsaicin-treated axons, preventing mitochondrial fission by overexpression of mutant dynamin-related protein 1 increased mitochondrial length, retained mitochondrial membrane potentials and reduced axonal loss upon capsaicin treatment.	Capsaicin	292-301	dynamin 1 like	Homo sapiens	162-187
26114658-0	2015	A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.	liensinine	38-48	dynamin 1 like	Homo sapiens	104-109
26114658-5	2015	Mechanistically, we found that inhibition of autophagy/mitophagy by liensinine enhanced doxorubicin-mediated apoptosis by triggering mitochondrial fission, which resulted from dephosphorylation and mitochondrial translocation of DNM1L.	liensinine	68-78	dynamin 1 like	Homo sapiens	229-234
26114658-5	2015	Mechanistically, we found that inhibition of autophagy/mitophagy by liensinine enhanced doxorubicin-mediated apoptosis by triggering mitochondrial fission, which resulted from dephosphorylation and mitochondrial translocation of DNM1L.	Doxorubicin	88-99	dynamin 1 like	Homo sapiens	229-234
25237193-1	2014	Drp1 is a dynamin-like GTPase that mediates mitochondrial and peroxisomal division in a process dependent on self-assembly and coupled to GTP hydrolysis.	Guanosine Triphosphate	23-26	dynamin 1 like	Homo sapiens	0-4
25217628-3	2014	A central player in fission is the cytoplasmic dynamin-related GTPase Drp1, which oligomerizes at the fission site and hydrolyzes GTP to drive membrane ingression.	Guanosine Triphosphate	63-66	dynamin 1 like	Homo sapiens	70-74
25284615-0	2014	MiRNA-30a inhibits AECs-II apoptosis by blocking mitochondrial fission dependent on Drp-1.	mirna-30a	0-9	dynamin 1 like	Homo sapiens	84-89
25445585-7	2014	Trolox, a ROS scavenger, decreased pSer616 Drp1 level and mitochondrial fission after A/R.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	0-6	dynamin 1 like	Homo sapiens	43-47
25445585-10	2014	FK506, a calcineurin inhibitor, blocked the decrease in expression of inactivated pSer637 Drp1 and mitochondrial fission.	Tacrolimus	0-5	dynamin 1 like	Homo sapiens	90-94
25445585-11	2014	Our findings reveal the following novel molecular mechanisms controlling mitochondrial fission during A/R injury of cardiomyocytes: (1) ROS are upstream initiators of mitochondrial fission; and (2) the increased mitochondrial fission is resulted from both increased activation and decreased inactivation of Drp1 through Cdk1, PKCdelta, and calcineurin-mediated pathways, respectively.	Reactive Oxygen Species	136-139	dynamin 1 like	Homo sapiens	307-311
25237193-7	2014	Moreover, Drp1 promoted membrane tethering dependent on the intrinsic curvature of the membrane lipids and on GTP.	Guanosine Triphosphate	110-113	dynamin 1 like	Homo sapiens	10-14
25237193-8	2014	Interestingly, Drp1 concentrated at membrane contact surfaces and, in the presence of GTP, formed discrete clusters on the vesicles.	Guanosine Triphosphate	86-89	dynamin 1 like	Homo sapiens	15-19
24902900-2	2014	Amyloid beta (Abeta) and peroxynitrite induce mitochondrial fragmentation and neuronal cell death by abnormal activation of dynamin-related protein 1 (DRP1), a large GTPase that regulates mitochondrial fission.	Peroxynitrous Acid	25-38	dynamin 1 like	Homo sapiens	124-149
25008790-0	2014	Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting.	Hydrogen Peroxide	34-51	dynamin 1 like	Homo sapiens	75-79
25008790-7	2014	Finally, B2-induced dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation and cell death could be reversed by NAC and inhibitors of Drp1 and Mdivi in GF-1 cells.	Acetylcysteine	126-129	dynamin 1 like	Homo sapiens	47-51
25008790-9	2014	H2O2 activates Drp1, resulting in its association with the mitochondria, mitochondrial fission and cell death in vitro and in vivo.	Hydrogen Peroxide	0-4	dynamin 1 like	Homo sapiens	15-19
24902900-2	2014	Amyloid beta (Abeta) and peroxynitrite induce mitochondrial fragmentation and neuronal cell death by abnormal activation of dynamin-related protein 1 (DRP1), a large GTPase that regulates mitochondrial fission.	Peroxynitrous Acid	25-38	dynamin 1 like	Homo sapiens	151-155
24902900-3	2014	The exact mechanisms of mitochondrial fragmentation and DRP1 overactivation in AD remain unknown; however, DRP1 serine 616 (S616) phosphorylation is likely involved.	Serine	112-118	dynamin 1 like	Homo sapiens	107-111
25149858-0	2014	Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant.	dronpa	104-110	dynamin 1 like	Homo sapiens	48-52
24899388-6	2014	Inhibition of HIF-1alpha with echinomycin blocked hypoxia-induced expression of Drp1.	Echinomycin	30-41	dynamin 1 like	Homo sapiens	80-84
25118928-0	2014	The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.	GSK2578215A	20-31	dynamin 1 like	Homo sapiens	94-99
24522274-0	2014	MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner.	N-Methyl-3,4-methylenedioxyamphetamine	0-4	dynamin 1 like	Homo sapiens	73-77
24947026-8	2014	Phosphorylation of Drp1 at Ser(616) was decreased (pre vs. post: 0.81 +- 0.15 vs. 0.58 +- 0.14 arbitrary units; P &lt; 0.05) following the intervention.	Serine	27-30	dynamin 1 like	Homo sapiens	19-23
25036098-8	2014	We show that a four lysine module located within the B insert of Drp1 interacts preferentially with CL over other anionic lipids.	Lysine	20-26	dynamin 1 like	Homo sapiens	65-69
25036098-9	2014	This interaction dramatically enhances Drp1 oligomerization and assembly-stimulated GTP hydrolysis.	Guanosine Triphosphate	84-87	dynamin 1 like	Homo sapiens	39-43
24740540-7	2014	To investigate whether H2O2-induced fragmentation was mediated by dynamin-related protein 1, we incubated cells with mDivi1, an inhibitor of dynamin-related protein 1 translocation to mitochondria.	Hydrogen Peroxide	23-27	dynamin 1 like	Homo sapiens	66-91
24740540-7	2014	To investigate whether H2O2-induced fragmentation was mediated by dynamin-related protein 1, we incubated cells with mDivi1, an inhibitor of dynamin-related protein 1 translocation to mitochondria.	Hydrogen Peroxide	23-27	dynamin 1 like	Homo sapiens	141-166
24610934-3	2014	In nonasthmatic human airway smooth muscle (ASM) cells, CS extract (CSE) induced mitochondrial fragmentation and damages their networked morphology in a concentration-dependent fashion, via increased expression of mitochondrial fission protein dynamin-related protein 1 (Drp1) and decreased fusion protein mitofusin (Mfn) 2.	Cesium	56-58	dynamin 1 like	Homo sapiens	271-275
24681098-3	2014	Inhibition of dynamin related protein 1 (Drp1) results in reduced ROS levels and transcriptional activity of NF-kappaB leading to diminished proliferation and CD95L-dependent activation-induced cell death (AICD).	Reactive Oxygen Species	66-69	dynamin 1 like	Homo sapiens	14-39
24681098-3	2014	Inhibition of dynamin related protein 1 (Drp1) results in reduced ROS levels and transcriptional activity of NF-kappaB leading to diminished proliferation and CD95L-dependent activation-induced cell death (AICD).	Reactive Oxygen Species	66-69	dynamin 1 like	Homo sapiens	41-45
24610934-3	2014	In nonasthmatic human airway smooth muscle (ASM) cells, CS extract (CSE) induced mitochondrial fragmentation and damages their networked morphology in a concentration-dependent fashion, via increased expression of mitochondrial fission protein dynamin-related protein 1 (Drp1) and decreased fusion protein mitofusin (Mfn) 2.	Cesium	56-58	dynamin 1 like	Homo sapiens	244-269
24610934-5	2014	Inhibiting Drp1 prevented CSE effects on mitochondrial networks and ROS generation, whereas blocking Mfn2 had the opposite, detrimental effect.	Reactive Oxygen Species	68-71	dynamin 1 like	Homo sapiens	11-15
24631294-5	2014	When myocytes were exposed to hydrogen peroxide (H2O2), they increased DRP1 expression and mitochondrial fragmentation, resulting in DeltaPsim depolarization and insulin resistance.	Hydrogen Peroxide	30-47	dynamin 1 like	Homo sapiens	71-75
24177748-0	2014	Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells.	Butyric Acid	0-15	dynamin 1 like	Homo sapiens	24-28
24631294-5	2014	When myocytes were exposed to hydrogen peroxide (H2O2), they increased DRP1 expression and mitochondrial fragmentation, resulting in DeltaPsim depolarization and insulin resistance.	Hydrogen Peroxide	49-53	dynamin 1 like	Homo sapiens	71-75
24631294-6	2014	When DRP1 was suppressed by siRNA, H2O2-induced mitochondrial dysfunction and insulin resistance were restored.	Hydrogen Peroxide	35-39	dynamin 1 like	Homo sapiens	5-9
24631294-9	2014	CONCLUSIONS: A mutual enhancement between DRP1 and ROS could promote mitochondrial dysfunction and inhibition of insulin signal transduction.	Reactive Oxygen Species	51-54	dynamin 1 like	Homo sapiens	42-46
24177748-8	2014	DRP1 is activated by cyclin B1-CDK1 complex by its ser616 phosphorylation in which both cyclin B1-CDK1 complex and phospho-DRP1 (ser616) were strongly reduced by NaBt treatment.	NABT	162-166	dynamin 1 like	Homo sapiens	123-127
24177748-9	2014	DRP1 was observed to be regulated by apoptosis as pan-caspase inhibitor showing rescue from NaBt-induced apoptosis also caused the reversal of DRP1 to the normal level as in control proliferating cells.	NABT	92-96	dynamin 1 like	Homo sapiens	0-4
24177748-9	2014	DRP1 was observed to be regulated by apoptosis as pan-caspase inhibitor showing rescue from NaBt-induced apoptosis also caused the reversal of DRP1 to the normal level as in control proliferating cells.	NABT	92-96	dynamin 1 like	Homo sapiens	143-147
24177748-10	2014	Together, these findings suggest that NaBt can modulate mitochondrial fission and fusion by regulating the level of DRP1 and induce cell cycle arrest and apoptosis in human CRC cells.	NABT	38-42	dynamin 1 like	Homo sapiens	116-120
24733894-6	2014	Interference of HCV-induced mitochondrial fission and mitophagy by Drp1 silencing suppressed HCV secretion, with a concomitant decrease in cellular glycolysis and ATP levels, as well as enhanced innate immune signaling.	Adenosine Triphosphate	163-166	dynamin 1 like	Homo sapiens	67-71
24631294-3	2014	METHODS AND RESULTS: DRP1-expressing H9c2 myocytes, which had fragmented mitochondria with mitochondrial membrane potential (DeltaPsim) depolarization, exhibited attenuated insulin signaling and 2-deoxy-d-glucose (2-DG) uptake, indicating insulin resistance.	Deoxyglucose	195-212	dynamin 1 like	Homo sapiens	21-25
24631294-3	2014	METHODS AND RESULTS: DRP1-expressing H9c2 myocytes, which had fragmented mitochondria with mitochondrial membrane potential (DeltaPsim) depolarization, exhibited attenuated insulin signaling and 2-deoxy-d-glucose (2-DG) uptake, indicating insulin resistance.	Deoxyglucose	214-218	dynamin 1 like	Homo sapiens	21-25
24631294-4	2014	Treatment of the DRP1-expressing myocytes with Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride (TMPyP) significantly improved insulin resistance and mitochondrial dysfunction.	mn(iii)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride	47-105	dynamin 1 like	Homo sapiens	17-21
24631294-4	2014	Treatment of the DRP1-expressing myocytes with Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride (TMPyP) significantly improved insulin resistance and mitochondrial dysfunction.	tetra(4-N-methylpyridyl)porphine	107-112	dynamin 1 like	Homo sapiens	17-21
24177748-8	2014	DRP1 is activated by cyclin B1-CDK1 complex by its ser616 phosphorylation in which both cyclin B1-CDK1 complex and phospho-DRP1 (ser616) were strongly reduced by NaBt treatment.	NABT	162-166	dynamin 1 like	Homo sapiens	0-4
24206264-1	2014	BACKGROUND AND PURPOSE: Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and is thought to promote Bax/Bak-induced cytochrome c release during apoptosis.	bakuchiol	118-121	dynamin 1 like	Homo sapiens	24-49
24206264-1	2014	BACKGROUND AND PURPOSE: Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and is thought to promote Bax/Bak-induced cytochrome c release during apoptosis.	bakuchiol	118-121	dynamin 1 like	Homo sapiens	51-55
23813973-5	2013	In both LRRK2 G2019S-expressing cells and PD patient fibroblasts carrying this specific mutant, treatment with P110, a selective peptide inhibitor of fission dynamin-related protein 1 (Drp1) recently developed in our lab, reduced mitochondrial fragmentation and damage, and corrected excessive autophagy.	Cytidine Diphosphate	111-115	dynamin 1 like	Homo sapiens	158-183
24206264-8	2014	ABT-737 decreased maximal OCR measured in the presence of uncoupler in both WT and Drp1 KO MEF, consistent with respiratory impairment due to release of cytochrome c.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	dynamin 1 like	Homo sapiens	83-87
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	58-61	dynamin 1 like	Homo sapiens	9-13
24508339-1	2014	Mitochondrial fission requires recruitment of dynamin-related protein 1 (Drp1) to the mitochondrial surface and activation of its GTP-dependent scission function.	Guanosine Triphosphate	130-133	dynamin 1 like	Homo sapiens	46-71
24508339-1	2014	Mitochondrial fission requires recruitment of dynamin-related protein 1 (Drp1) to the mitochondrial surface and activation of its GTP-dependent scission function.	Guanosine Triphosphate	130-133	dynamin 1 like	Homo sapiens	73-77
24508339-7	2014	Addition of ADP relieves this inhibition and promotes Drp1 assembly into spirals with enhanced GTP hydrolysis.	Adenosine Diphosphate	12-15	dynamin 1 like	Homo sapiens	54-58
24508339-7	2014	Addition of ADP relieves this inhibition and promotes Drp1 assembly into spirals with enhanced GTP hydrolysis.	Guanosine Triphosphate	95-98	dynamin 1 like	Homo sapiens	54-58
24397920-5	2014	We also found that (R)-bicalutamide differentially modulated dynamin-related protein (Drp-1) expression in LNCaP and LNCaP-Rbic cells.	(R)-Bicalutamide	19-35	dynamin 1 like	Homo sapiens	86-91
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	94-102	dynamin 1 like	Homo sapiens	50-54
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	94-102	dynamin 1 like	Homo sapiens	56-81
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	94-102	dynamin 1 like	Homo sapiens	113-117
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	94-102	dynamin 1 like	Homo sapiens	113-117
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	159-167	dynamin 1 like	Homo sapiens	50-54
24073738-5	2013	This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission.	Ceramides	159-167	dynamin 1 like	Homo sapiens	56-81
24231356-10	2013	These data indicate that inhibition of DRP1-dependent excessive mitochondrial fission with a P110-TAT-like inhibitor may prevent or slow the progression of HD.	p110-tat	93-101	dynamin 1 like	Homo sapiens	39-43
23772688-8	2013	Importantly, inhibition of Drp1 reversed the effects of knocking down Pink1 on neuronal death and ATP production in response to OGD.	Adenosine Triphosphate	98-101	dynamin 1 like	Homo sapiens	27-31
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	148-151	dynamin 1 like	Homo sapiens	9-13
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	Adenosine Triphosphate	176-179	dynamin 1 like	Homo sapiens	9-13
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	Oxygen	202-204	dynamin 1 like	Homo sapiens	9-13
24206264-11	2014	Pro-apoptotic Bax was unaltered, whereas Bak was up-regulated in Drp1 KO MEF.	bakuchiol	41-44	dynamin 1 like	Homo sapiens	65-69
24206264-13	2014	However, Drp1 may contribute to ABT-737-induced respiratory changes and the kinetics of cytochrome c release.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	32-35	dynamin 1 like	Homo sapiens	9-13
24302731-6	2014	Knockdown of FIP1/RCP or inhibition of Drp1 markedly impaired mitochondrial remodeling and actin assembly, involving Rab11a-mediated mitochondrial dynamics in E4orf4-induced signaling.	e4orf4	159-165	dynamin 1 like	Homo sapiens	39-43
24897381-4	2014	Dexamethasone increases expression of several autophagy genes, including ATG5, LC3, BECN1, and SQSTM1 and triggers AMPK-dependent mitochondrial fragmentation associated with increased DNM1L protein levels.	Dexamethasone	0-13	dynamin 1 like	Homo sapiens	184-189
23813973-5	2013	In both LRRK2 G2019S-expressing cells and PD patient fibroblasts carrying this specific mutant, treatment with P110, a selective peptide inhibitor of fission dynamin-related protein 1 (Drp1) recently developed in our lab, reduced mitochondrial fragmentation and damage, and corrected excessive autophagy.	Cytidine Diphosphate	111-115	dynamin 1 like	Homo sapiens	185-189
23813973-6	2013	LRRK2 G2019S directly bound to and phosphorylated Drp1 at Threonine595, whereas P110 treatment abolished this phosphorylation.	threonine595	58-70	dynamin 1 like	Homo sapiens	50-54
23798729-7	2013	Phosphorylation of a conserved Ser residue adjacent to the microtubule-binding exon released Drp1-x01 from microtubules and promoted mitochondrial fragmentation in a splice form-specific manner.	Serine	31-34	dynamin 1 like	Homo sapiens	93-97
24073738-8	2013	However, inhibition of mitochondrial fission via Drp1 knockdown completely protected the myotubes and fibre bundles from ceramide-induced metabolic disruption, including maintained mitochondrial respiration, reduced H2O2 levels and unaffected insulin signalling.	Ceramides	121-129	dynamin 1 like	Homo sapiens	49-53
23977156-1	2013	Human dynamin-1-like protein (DNM1L) is a GTP-driven molecular machine that segregates mitochondria and peroxisomes.	Guanosine Triphosphate	42-45	dynamin 1 like	Homo sapiens	6-28
23977156-1	2013	Human dynamin-1-like protein (DNM1L) is a GTP-driven molecular machine that segregates mitochondria and peroxisomes.	Guanosine Triphosphate	42-45	dynamin 1 like	Homo sapiens	30-35
23977156-3	2013	The GTPase domain of DNM1L is structurally related to that of dynamin and binds the nucleotide 5"-Guanylyl-imidodiphosphate (GMP-PNP) via five highly conserved motifs, whereas the BSE folds into a pocket at the opposite side.	nucleotide 5"-guanylyl-imidodiphosphate	84-123	dynamin 1 like	Homo sapiens	21-26
23977156-3	2013	The GTPase domain of DNM1L is structurally related to that of dynamin and binds the nucleotide 5"-Guanylyl-imidodiphosphate (GMP-PNP) via five highly conserved motifs, whereas the BSE folds into a pocket at the opposite side.	Guanylyl Imidodiphosphate	125-132	dynamin 1 like	Homo sapiens	21-26
23792636-6	2013	Further, PXN mutants, through their interactions with BCL-2 and DRP-1, could regulate cisplatin drug resistance in human lung cancer cells.	Cisplatin	86-95	dynamin 1 like	Homo sapiens	64-69
23979843-4	2013	Inhibition of DRP1 activity using a GTP hydrolysis-defective mutant (Ad-K38A) attenuated fatty acid-induced ER expansion and mitochondrial fission.	Guanosine Triphosphate	36-39	dynamin 1 like	Homo sapiens	14-18
23979843-4	2013	Inhibition of DRP1 activity using a GTP hydrolysis-defective mutant (Ad-K38A) attenuated fatty acid-induced ER expansion and mitochondrial fission.	Fatty Acids	89-99	dynamin 1 like	Homo sapiens	14-18
24040144-12	2013	Piperlongumine-induced apoptosis appeared to be mediated by Drp1-dependent mitochondrial fission since the apoptotic response was attenuated by the presence of the Drp1 inhibitor mDivi-1.	piperlonguminine	0-14	dynamin 1 like	Homo sapiens	60-64
24040144-12	2013	Piperlongumine-induced apoptosis appeared to be mediated by Drp1-dependent mitochondrial fission since the apoptotic response was attenuated by the presence of the Drp1 inhibitor mDivi-1.	piperlonguminine	0-14	dynamin 1 like	Homo sapiens	164-168
23798729-2	2013	Dynamin-related protein 1 (Drp1) is a guanosine triphosphate-hydrolyzing mechanoenzyme important for mitochondrial fission and programmed cell death.	Guanosine Triphosphate	38-60	dynamin 1 like	Homo sapiens	0-25
23798729-2	2013	Dynamin-related protein 1 (Drp1) is a guanosine triphosphate-hydrolyzing mechanoenzyme important for mitochondrial fission and programmed cell death.	Guanosine Triphosphate	38-60	dynamin 1 like	Homo sapiens	27-31
23798729-5	2013	A major isoform in immune cells, Drp1-x01 required oligomeric assembly and Arg residues in alternative exon 3 for microtubule targeting.	Arginine	75-78	dynamin 1 like	Homo sapiens	33-37
23798729-6	2013	Drp1-x01 stabilized and bundled microtubules and attenuated staurosporine-induced mitochondrial fragmentation and apoptosis.	Staurosporine	60-73	dynamin 1 like	Homo sapiens	0-4