PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35176556-0	2022	Indirubin-3"-alkoxime derivatives for upregulation of Wnt signaling through dual inhibition of GSK-3beta and the CXXC5-Dvl interaction.	indirubin-3"-alkoxime	0-21	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	119-122
35353333-3	2022	METHODS: In a single-blind randomized clinical trial, 92 patients with acute brucellosis were randomly divided in two treatment groups who received a triple drug regimen including doxycycline, streptomycin, and hydroxychloroquine (DSH) for 4 and 6 weeks.	Hydroxychloroquine	211-229	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	231-234
31235524-10	2019	Our observations agree with previous results arguing for FZD conformation-dependent functional selectivity between DVL and heterotrimeric G proteins.	fzd	57-60	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	115-118
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	KY19382	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	221-232
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	KY19382	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	234-237
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	indirubin-3'-monoxime	49-70	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	221-232
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	indirubin-3'-monoxime	49-70	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	234-237
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	indirubin-3'-monoxime	72-75	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	221-232
33751552-2	2021	KY19382, one of the newly synthesized analogs of indirubin-3"-monoxime (I3O), was identified as a Wnt/beta-catenin signaling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and Dishevelled (Dvl) interaction.	indirubin-3'-monoxime	72-75	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	234-237
33534106-5	2021	AmB-DVL were characterized in terms of incorporation parameters, stability, and elasticity, and evaluated in vitro for their permeation properties, cytotoxicity, and anti-leishmanial activity.	Amphotericin B	0-3	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	4-7
33534106-6	2021	The AmB-DVL exhibited a translucent fluid gel-like aspect and a yellow color, a mean size of 132 nm (PdI <= 0.1), zeta potential values around zero (mV), and an AmB incorporation efficiency of 95%.	Amphotericin B	4-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	8-11
33534106-6	2021	The AmB-DVL exhibited a translucent fluid gel-like aspect and a yellow color, a mean size of 132 nm (PdI <= 0.1), zeta potential values around zero (mV), and an AmB incorporation efficiency of 95%.	Amphotericin B	161-164	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	8-11
33534106-8	2021	AmB-DVL was able to reduce promastigote viability in a dose-dependent manner, as well as the number of intracellular amastigotes in THP-1 macrophages.	Amphotericin B	0-3	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	4-7
31018001-9	2021	The presence of depressive symptoms and alcohol use were the factors most strongly associated with an increased risk of DSH.	Alcohols	40-47	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	120-123
33386417-5	2021	This protocol, initially applied to a range of low molecular weight standard peptides, allowed detection of [(Peptide-H)+56FeII]+ complex ion for iron(II)-chelating peptides (GGH, EAH, DAH, betaAH, DMH, DTH, DSH).	ammonium ferrous sulfate	146-154	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	208-211
32512698-1	2020	The aim of this work was to investigate the effect of date seed water-soluble polysaccharides (DSP) and hemicellulose (DSH) as dietary fiber sources in enhancing the wheat bread"s quality.	hemicellulose	104-117	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	119-122
32512698-6	2020	Furthermore, bread evaluation revealed that the addition of DSH considerably improved the volume (by 24.22%) and the texture profile of bread (decrease of the hardness and chewiness by 41.54% and 33.81%, respectively), compared to control bread (prepared with FLBM).	flbm	260-264	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	60-63
32512698-8	2020	Results in this work demonstrate that hemicellulose fraction extracted from date seeds (DSH) and added with a level of 0.75% to FLBM represents the component that improved bread quality the best.	hemicellulose	38-51	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	88-91
31571476-3	2019	Sulindac, a drug that targets protein Dvl of the Wnt/Dvl/beta-catenin pathway, which regulates cancer gene expression, has been reported to significantly reduce the incidence and the risk of death from colorectal cancer and other types of cancer.	Sulindac	0-8	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	38-41
31571476-3	2019	Sulindac, a drug that targets protein Dvl of the Wnt/Dvl/beta-catenin pathway, which regulates cancer gene expression, has been reported to significantly reduce the incidence and the risk of death from colorectal cancer and other types of cancer.	Sulindac	0-8	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	53-56
31136861-1	2019	This paper describes a new fluorescent chemosensor (DSH) based on dipeptide conjugated with dansyl group, which was synthesized by solid phase peptide synthesis (SPPS) technology.	Dipeptides	66-75	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	52-55
31136861-1	2019	This paper describes a new fluorescent chemosensor (DSH) based on dipeptide conjugated with dansyl group, which was synthesized by solid phase peptide synthesis (SPPS) technology.	Peptides	68-75	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	52-55
31136861-2	2019	DSH exhibited a highly selective and sensitive toward Zn2+ ions by "turn-on" response based on generation of monomer-excimer mechanism in aqueous solutions, and the detection limit was calculated at 11.2 nM.	Zinc	54-58	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
31136861-3	2019	In addition, the reversible of DSH-Zn with Na2EDTA establishes the reuse of DSH, and the circulation effect was very good.	Edetate disodium	43-50	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	31-34
31136861-3	2019	In addition, the reversible of DSH-Zn with Na2EDTA establishes the reuse of DSH, and the circulation effect was very good.	Edetate disodium	43-50	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	76-79
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Water	23-28	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	10-13
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Zinc	96-100	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	10-13
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Zinc	96-100	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	227-230
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Edetate disodium	110-117	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	10-13
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Edetate disodium	110-117	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	227-230
31117394-3	2019	We previously reported that a chemical catalyst (DSH) conjugated with a nucleosome-binding ligand can activate an acyl-CoA and promote site-selective lysine acylation of histones in test tubes.	Lysine	150-156	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	49-52
30125555-7	2018	Ethanol resulted in a significant increase of Dvl protein and mRNA expression, and decreased Nxn/Dvl interaction ratio but promoted the interaction of Dvl with Fzd and Pi4k2a; formation of this complex induced phosphatidylinositol 4-phosphate [PI(4)P] production.	Ethanol	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	46-49
30237173-5	2018	Further, we identified a triad of evolutionarily conserved cysteines in the FZD linker domain that is crucial for receptor membrane expression and recruitment of DVL.	Cysteine	59-68	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	162-165
30006145-2	2018	We previously developed a chemical catalyst, DSH, which activates a chemically stable thioester including acyl-CoA, allowing the site-selective lysine acylation of histones under physiological conditions.	Acyl Coenzyme A	106-114	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	45-48
30006145-2	2018	We previously developed a chemical catalyst, DSH, which activates a chemically stable thioester including acyl-CoA, allowing the site-selective lysine acylation of histones under physiological conditions.	Lysine	144-150	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	45-48
30006145-4	2018	We, herein, conducted a kinetic analysis of the ability of DSH and several derivatives to mediate lysine acetylation to better understand the structural elements essential for high acetylation activity under physiological conditions.	Lysine	98-104	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	59-62
30125555-10	2018	In conclusion, two-hit model of ethanol exposure disrupts NXN/DVL homeostatic status to allow DVL/FZD/PI4K2A complex formation and stimulates PI(4)P production.	Ethanol	32-39	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	62-65
30125555-10	2018	In conclusion, two-hit model of ethanol exposure disrupts NXN/DVL homeostatic status to allow DVL/FZD/PI4K2A complex formation and stimulates PI(4)P production.	Ethanol	32-39	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	94-97
31117394-4	2019	In-cell acylation by this catalyst system is challenging, however, mainly due to the low cell permeability of acyl-CoA and the propensity of DSH to form inactive disulfide.	Disulfides	162-171	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	141-144
30208247-0	2018	Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.	cryptotanshinone	0-16	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	18-21
30208247-0	2018	Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.	Dinoprostone	67-83	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	18-21
30208247-4	2018	In this study, we used Cryptotansinone (Dsh-003) (MW 269.14) from Danshen to investigate their effect and corresponding mechanism of action in PGE2-treated HA22T cells.	cryptotansinone	23-38	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	40-43
30208247-5	2018	Dsh-003 inhibited HA22T cell viability and further induced cell apoptosis in PGE2-treated HA22T cells.	Dinoprostone	77-81	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
30208247-7	2018	We also observed that Dsh-003 blocked PGE2-induced cell migration by down-regulating PGE2-induced beta-catenin expression and by up-regulating E-cadherin and GSK3-beta expression.	Dinoprostone	38-42	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	22-25
30208247-7	2018	We also observed that Dsh-003 blocked PGE2-induced cell migration by down-regulating PGE2-induced beta-catenin expression and by up-regulating E-cadherin and GSK3-beta expression.	Dinoprostone	85-89	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	22-25
30125555-7	2018	Ethanol resulted in a significant increase of Dvl protein and mRNA expression, and decreased Nxn/Dvl interaction ratio but promoted the interaction of Dvl with Fzd and Pi4k2a; formation of this complex induced phosphatidylinositol 4-phosphate [PI(4)P] production.	Ethanol	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	97-100
30125555-10	2018	In conclusion, two-hit model of ethanol exposure disrupts NXN/DVL homeostatic status to allow DVL/FZD/PI4K2A complex formation and stimulates PI(4)P production.	pi(4)p	142-148	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	62-65
30125555-7	2018	Ethanol resulted in a significant increase of Dvl protein and mRNA expression, and decreased Nxn/Dvl interaction ratio but promoted the interaction of Dvl with Fzd and Pi4k2a; formation of this complex induced phosphatidylinositol 4-phosphate [PI(4)P] production.	Ethanol	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	97-100
30125555-8	2018	Ethanol and LPS treatments provoked similar alterations on NXN/DVL interaction and its downstream effect in HSC/VL17A co-culture system.	Ethanol	0-7	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	63-66
29500467-10	2018	The model suggests control strategies where the activities of the enzyme phosphoinositide 4-phosphate 5-kinase I (PIP5KI) or the PI4K + PIP5KI + DVL protein complex are decreased and cause an efficacious reduction in PI(4,5)P2 levels while avoiding undesirable alterations in other phosphoinositide pools.	pi(4,5)p2	217-226	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	145-148
30154457-4	2018	Upon engagement of the cognate Eph receptor, ephrinB2 is tyrosine phosphorylated, which disrupts the ephrinB2/Dsh/TBC1d24 complex.	Tyrosine	57-65	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	110-113
29500467-10	2018	The model suggests control strategies where the activities of the enzyme phosphoinositide 4-phosphate 5-kinase I (PIP5KI) or the PI4K + PIP5KI + DVL protein complex are decreased and cause an efficacious reduction in PI(4,5)P2 levels while avoiding undesirable alterations in other phosphoinositide pools.	Phosphatidylinositols	73-89	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	145-148
23836490-3	2013	Dishevelled (Dvl/Dsh) is a multi-module protein and a key regulator of both the canonical Wnt and the PCP pathway.	pcp	102-105	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	13-16
28334810-8	2017	Our finding uncovers Vangl2-Dvl interaction as a key bi-functional switch that underlies the central logic of PCP signaling during morphogenesis, and provides new insight into PCP-related disorders in humans.	pcp	110-113	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	28-31
27799526-4	2016	Prodigiosin blocked Wnt/beta-catenin signaling by targeting multiple sites of this pathway, including the low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL), and glycogen synthase kinase-3beta (GSK3beta).	Prodigiosin	0-11	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	164-175
27799526-4	2016	Prodigiosin blocked Wnt/beta-catenin signaling by targeting multiple sites of this pathway, including the low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL), and glycogen synthase kinase-3beta (GSK3beta).	Prodigiosin	0-11	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	177-180
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	168-179
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	181-184
25869100-3	2015	In a concentration and time-dependent study, we observed that capsaicin treatment inhibits the activation of dishevelled (Dsh) protein DvI-1 in L3.6PL, PanC-1 and MiaPaCa-2 pancreatic cancer cells.	Capsaicin	62-71	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	122-125
25024088-4	2014	Here, we show that cholesterol selectively activates canonical Wnt signalling over non-canonical signalling under physiological conditions by specifically facilitating the membrane recruitment of the PDZ domain of Dvl and its interaction with other proteins.	Cholesterol	19-30	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	214-217
25024088-5	2014	Single-molecule imaging analysis shows that cholesterol is enriched around the Wnt-activated Frizzled and low-density lipoprotein receptor-related protein 5/6 receptors and plays an essential role for Dvl-mediated formation and maintenance of the canonical Wnt signalling complex.	Cholesterol	44-55	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	201-204
23472710-2	2013	The importance of these cascades is highlighted by lithium"s (the gold standard in BD psychopharmacology) ability to inhibit multiple critical loci in second messenger/signal transduction cascades including protein kinase C (involved in the IP3/PIP2 pathway) and GSK-3beta (canonically identified in the Wnt/Fz/Dvl/GSK-3beta cascade).	Lithium	51-58	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	311-314
23472710-2	2013	The importance of these cascades is highlighted by lithium"s (the gold standard in BD psychopharmacology) ability to inhibit multiple critical loci in second messenger/signal transduction cascades including protein kinase C (involved in the IP3/PIP2 pathway) and GSK-3beta (canonically identified in the Wnt/Fz/Dvl/GSK-3beta cascade).	Inositol 1,4,5-Trisphosphate	241-244	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	311-314
28481871-7	2017	Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficient Dvl recruitment to the plasma membrane upon Wnt stimulation of Fzd receptor and for the propagation of downstream signals.	Phosphatidic Acids	38-55	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	23-26
28481871-7	2017	Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficient Dvl recruitment to the plasma membrane upon Wnt stimulation of Fzd receptor and for the propagation of downstream signals.	Phosphatidic Acids	38-55	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	96-99
28481871-8	2017	We conclude that the PCP pathway contributes significantly to the motility and hence the invasiveness of GBM cells, and that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiquitination mechanism.	pcp	163-166	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	191-194
25793621-5	2015	Accordingly after initiation of differentiation endogenous ROS activates DVL in a redox-dependent manner leading to a transient activation of down-stream beta-catenin signaling, followed by continuous auto/paracrine WNT signaling, which crucially depends on lipid rafts.	Reactive Oxygen Species	59-62	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	73-76
25793621-6	2015	Our simulation studies further illustrate the elaborate spatio-temporal regulation of DVL, which, depending on its concentration and localization, may either act as direct inducer of the transient ROS/beta-catenin signal or as amplifier during continuous auto-/parcrine WNT/beta-catenin signaling.	Reactive Oxygen Species	197-200	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	86-89
24606934-2	2014	A downstream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interactions, binds to the Frizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-dependent.	Phosphatidic Acids	172-189	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	52-63
24606934-2	2014	A downstream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interactions, binds to the Frizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-dependent.	Phosphatidic Acids	172-189	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	65-68
24606934-2	2014	A downstream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interactions, binds to the Frizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-dependent.	Phosphatidic Acids	191-193	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	52-63
24606934-2	2014	A downstream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interactions, binds to the Frizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-dependent.	Phosphatidic Acids	191-193	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	65-68
23836490-3	2013	Dishevelled (Dvl/Dsh) is a multi-module protein and a key regulator of both the canonical Wnt and the PCP pathway.	pcp	102-105	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	17-20
23821037-7	2013	Intriguingly, Dvl and Gpr125 were able to recruit a subset of PCP components into membrane subdomains, suggesting that Gpr125 may modulate the composition of Wnt/PCP membrane complexes.	pcp	162-165	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	14-17
23475338-10	2013	The DSH was also found to be highly correlated with the DWH, although slightly higher deviations were generally found.	CHEMBL1738792	56-59	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	4-7
23821037-7	2013	Intriguingly, Dvl and Gpr125 were able to recruit a subset of PCP components into membrane subdomains, suggesting that Gpr125 may modulate the composition of Wnt/PCP membrane complexes.	pcp	62-65	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	14-17
16256287-2	2006	In standard conditions, by exposure to relative humidity even below 60% at 25 degrees C, the anhydrous form DS gives rise to a hydrate species DSH, a tetrahydrate form different from that obtained by crystallisation from water and previously described.	Deuterium	108-110	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	143-146
23362456-4	2013	We identified peptide aptamers against Dishevelled (Dsh) and beta-catenin (beta-cat) to target the Wnt signaling pathway and demonstrate that these FN3-based MONOBODYs (FNDYs) can be used to perturb protein activities both in vitro and in vivo.	2-hydroxy-3,5-dinitrobenzohydrazide	52-55	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	39-50
23214393-8	2012	Patients with DSH and with SA in the past (77% studied group), achieved similar results in CISS and DINEMO vs. the self-harming patients without SA in the past.	sa	145-147	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	14-17
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	tripeptide K-26	15-25	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	71-74
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	tripeptide K-26	15-25	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	203-206
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Valine	31-34	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	71-74
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Valine	31-34	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	203-206
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Tryptophan	35-38	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	71-74
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Tryptophan	35-38	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	203-206
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Valine	39-42	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	71-74
21044957-4	2010	Given that the tripeptide VWV (Val-Trp-Val) binds to the PDZ domain of Dvl, we searched publically available databases to identify proteins containing the VWV motif at the C terminus that could be novel Dvl-binding partners.	Valine	39-42	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	203-206
18760999-7	2008	We find that Thr-324 is phosphorylated in a Dvl-dependent manner.	Threonine	13-16	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	44-47
20603214-3	2010	Here, we report that DDIP (Dishevelled-DEP domain Interacting Protein, also named as Spats1, spermatogenesis associated, serine-rich 1), a novel protein that interacts with Dvl, regulates Wnt signaling.	Serine	121-127	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	27-38
20603214-3	2010	Here, we report that DDIP (Dishevelled-DEP domain Interacting Protein, also named as Spats1, spermatogenesis associated, serine-rich 1), a novel protein that interacts with Dvl, regulates Wnt signaling.	Serine	121-127	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	173-176
20457807-4	2010	Ror2 can associate with Frizzled7 (Fz7) via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after Wnt5a stimulation.	Cysteine	62-70	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	149-152
19561074-4	2009	Dvl directly interacted with and activated PI4KII alpha by increasing its V(max) for ATP and PtdIns.	Adenosine Triphosphate	85-88	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
19561074-4	2009	Dvl directly interacted with and activated PI4KII alpha by increasing its V(max) for ATP and PtdIns.	Phosphatidylinositols	93-99	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
18180158-0	2008	Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.	indole-2-amide	0-14	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	47-58
18180158-0	2008	Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.	indole-2-amide	0-14	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	97-108
18180158-1	2008	We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7).	indole-2-amide	40-54	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	111-122
18180158-1	2008	We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7).	indole-2-amide	40-54	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	124-127
16956403-6	2006	RESULTS: In 3D-CRT (3-field and 4-field) the dose parameters differed most in the mid-dose region: the DWH showed significantly lower doses to the rectum (8.7% +/- 4.2%) compared to the DWH(3) and the DSH.	CHEMBL1738792	103-106	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	201-204
16604061-7	2006	In addition, association between Dvl and NRX is inhibited by H(2)O(2) treatment.	Hydrogen Peroxide	61-69	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	33-36
16256287-2	2006	In standard conditions, by exposure to relative humidity even below 60% at 25 degrees C, the anhydrous form DS gives rise to a hydrate species DSH, a tetrahydrate form different from that obtained by crystallisation from water and previously described.	TETRAHYDRATE	150-162	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	143-146
14730010-4	2004	Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to PCP.	pcp	153-156	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	16-19
16233851-6	2005	These findings indicate that 6-DSH and 2-DSH have the same ability to promote the growth of human NSPCs as intact heparin.	Heparin	114-121	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	41-44
16233851-7	2005	Our results suggest that these two novel heparin derivates, especially 6-DSH, could be used in clinical applications for ex vivo human NSPC culture, as a lower-risk growth co-adjuvant than intact heparin.	Heparin	41-48	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	73-76
15121866-1	2004	Dvl is a key protein that transmits the Wnt signal to the canonical beta-catenin pathway and the noncanonical planar cell polarity (PCP) pathway.	pcp	132-135	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
15826504-0	2005	Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain.	13c	25-28	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	93-104
14988008-2	2004	Clozapine activates both Akt- and Dvl-mediated phosphorylation of GSK-3beta through phosphorylation at Ser9, and increased total cellular and intranuclear levels of beta-catenin.	Clozapine	0-9	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	34-37
14988008-4	2004	These results suggest that clozapine regulates the phosphorylation of GSK-3beta through Wnt signal pathways involving Dvl upstream but not through the PI3K-Akt pathway in SH-SY5Y cells.	Clozapine	27-36	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	118-121
12771126-3	2003	Although the intracellular protein Dishevelled (Dsh) plays a dual role in both the Wnt-beta-catenin and the PCP pathways, its potential involvement in the Wnt-Ca2+ pathway has not been investigated.	pcp	108-111	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	35-46
12773426-8	2003	In experiment 2, the effects of serum starvation, culture to confluency, and exposure to roscovitine on the distribution of AWC and DSH fibroblasts in various phases of the cell cycle were determined.	Roscovitine	89-100	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	132-135
12773426-10	2003	Specifically, a higher percentage of AWC and DSH nuclei were in the G0/G1 phase after cells were serum starved (83% vs. 96%) than were present in cycling cells (50% vs. 64%), after contact inhibition (61% vs. 88%), or after roscovitine (56% vs. 84%) treatment, respectively.	Roscovitine	224-235	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	45-48
12773426-16	2003	In experiment 4, the effect of calcium in the fusion medium on induction of oocyte activation and development of AWC-DSH-cloned embryos was determined.	Calcium	31-38	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	117-120
12773426-17	2003	The presence of calcium in the fusion medium induced a high incidence of cleavage of DSH oocytes (54.3%), while oocyte cleavage frequency was much lower in the absence of calcium (16.6%).	Calcium	16-23	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	85-88
12771126-3	2003	Although the intracellular protein Dishevelled (Dsh) plays a dual role in both the Wnt-beta-catenin and the PCP pathways, its potential involvement in the Wnt-Ca2+ pathway has not been investigated.	pcp	108-111	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	48-51
10944533-5	2000	Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress GSK-3beta-dependent phosphorylation of Axin.	axam	0-4	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	40-43
12632086-2	2003	Dishevelled (DVL) proteins are WNT signaling molecules implicated in beta-catenin pathway and PCP pathway.	pcp	94-97	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-11
12632086-2	2003	Dishevelled (DVL) proteins are WNT signaling molecules implicated in beta-catenin pathway and PCP pathway.	pcp	94-97	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	13-16
10944533-5	2000	Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress GSK-3beta-dependent phosphorylation of Axin.	axam	0-4	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	74-77
9056781-6	1997	At the level of gene expression, SGG positively regulates dpp expression and negatively regulates wg expression while DSH activity suppresses dpp expression and promotes wg expression.	dipalmitoylphosphatidylserine	142-145	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	118-121
9056781-7	1997	Sharp borders of gene expression correlating precisely with clone boundaries suggest that the effects of DSH and SGG on transcription of wg and dpp are not mediated by secreted factors but rather act through intracellular effectors.	dipalmitoylphosphatidylserine	144-147	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	105-108