PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	177-182	cystathionine beta-synthase	Mus musculus	55-58
638019-5	1978	Furthermore, the previously assumed beta-thionase hydrolysis of thiodiglycollic acid (Jones and Hathway, 1977) is now established in vivo, and the possible biogenesis of the N-acetyl-S-cysteinyl acetyl derivative is verified by another tracer study.	thiodiacetic acid	64-84	cystathionine beta-synthase	Mus musculus	36-49
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	177-182	cystathionine beta-synthase	Mus musculus	112-115
33864412-0	2021	Glucose-induced decrease of cystathionine beta-synthase mediates renal injuries.	Glucose	0-7	cystathionine beta-synthase	Mus musculus	28-55
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	177-182	cystathionine beta-synthase	Mus musculus	112-115
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	55-58
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	112-115
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	55-58
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	112-115
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	112-115
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	112-115
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	53-56
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	129-132
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	129-132
33864412-7	2021	The increases of nitrotyrosine either by cbs-siRNA or by glucose were restored by GYY4137, indicating that the H2 S donor may protect kidney from oxidative injury induced by CBS deficiency.	3-nitrotyrosine	17-30	cystathionine beta-synthase	Mus musculus	41-44
33864412-7	2021	The increases of nitrotyrosine either by cbs-siRNA or by glucose were restored by GYY4137, indicating that the H2 S donor may protect kidney from oxidative injury induced by CBS deficiency.	Deuterium	111-113	cystathionine beta-synthase	Mus musculus	41-44
33864412-8	2021	In diabetic kidneys, ubiquitinated CBS and nitrotyrosine were increased but restored by GYY4137.	GYY 4137	88-95	cystathionine beta-synthase	Mus musculus	35-38
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Deuterium	60-62	cystathionine beta-synthase	Mus musculus	231-234
33945828-8	2021	In vitro experiment, NaHS ameliorated the ferroptosis via increasing the protein expressions of SLC7A11, glutathione peroxidase 4 (GPX4), and cystathionine beta-synthase (CBS), reducing the pro-inflammatory cytokines, decreasing the levels of Fe2+, MDA, ROS, and lipid ROS.	sodium bisulfide	21-25	cystathionine beta-synthase	Mus musculus	142-169
33945828-8	2021	In vitro experiment, NaHS ameliorated the ferroptosis via increasing the protein expressions of SLC7A11, glutathione peroxidase 4 (GPX4), and cystathionine beta-synthase (CBS), reducing the pro-inflammatory cytokines, decreasing the levels of Fe2+, MDA, ROS, and lipid ROS.	sodium bisulfide	21-25	cystathionine beta-synthase	Mus musculus	171-174
33713531-13	2021	H2 S catalysed by CBS could recover testosterone synthesis in vitro and in vivo through inhibiting PDE expression via sulfhydryl modification and activating cAMP/PKA pathway.	Cyclic AMP	157-161	cystathionine beta-synthase	Mus musculus	18-21
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Oxygen	63-65	cystathionine beta-synthase	Mus musculus	231-234
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Testosterone	84-96	cystathionine beta-synthase	Mus musculus	0-3
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Deuterium	155-157	cystathionine beta-synthase	Mus musculus	0-3
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Hydrogen Peroxide	60-65	cystathionine beta-synthase	Mus musculus	231-234
33713531-10	2021	CBS overexpression inhibited while knockdown promoted LPS + H2 O2 induced injury in testosterone synthesis of MLTC-1 cells, though regulating the level of H2 S. The LPS + H2 O2 induced inhibition on cAMP and p-PKA was recovered by CBS overexpression, while addition of the specific inhibitor of PKA had opposite effects.	Cyclic AMP	199-203	cystathionine beta-synthase	Mus musculus	0-3
33713531-13	2021	H2 S catalysed by CBS could recover testosterone synthesis in vitro and in vivo through inhibiting PDE expression via sulfhydryl modification and activating cAMP/PKA pathway.	Deuterium	0-4	cystathionine beta-synthase	Mus musculus	18-21
33713531-13	2021	H2 S catalysed by CBS could recover testosterone synthesis in vitro and in vivo through inhibiting PDE expression via sulfhydryl modification and activating cAMP/PKA pathway.	Testosterone	36-48	cystathionine beta-synthase	Mus musculus	18-21
32383312-4	2021	Here we report that Cystathionine beta-synthase (CBS), a central enzyme in one-carbon metabolism, functionally interacts with the core circadian protein Cryptochrome1 (CRY1).	Carbon	79-85	cystathionine beta-synthase	Mus musculus	20-47
33483253-1	2021	Cystathionine beta-synthase deficient homocystinuria (HCU) is a life-threatening disorder of sulfur metabolism.	Sulfur	93-99	cystathionine beta-synthase	Mus musculus	0-27
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	55-74	cystathionine beta-synthase	Mus musculus	32-35
33271147-8	2021	During exposure to an effective CBS and CSE inhibitor (aminooxyacetic acid [AOAA]), the amplitude of oscillation and baseline expression of Per2 significantly increased.	Aminooxyacetic Acid	76-80	cystathionine beta-synthase	Mus musculus	32-35
33271147-11	2021	In conclusion, we showed that CBS/CSE/H2S pathway participates in the regulation of the circadian clock system.	Deuterium	38-41	cystathionine beta-synthase	Mus musculus	30-33
32383312-4	2021	Here we report that Cystathionine beta-synthase (CBS), a central enzyme in one-carbon metabolism, functionally interacts with the core circadian protein Cryptochrome1 (CRY1).	Carbon	79-85	cystathionine beta-synthase	Mus musculus	49-52
32383312-12	2021	We observed temporal variation in one-carbon and transsulfuration pathways attributable to CRY1 induced CBS activation.	Carbon	38-44	cystathionine beta-synthase	Mus musculus	104-107
32067580-3	2020	Mild or severe elevation in plasma total homocysteine was observed in Cbs+/- (6.1+-0.3 mumol/L) or Cbs-/- (309+-18 mumol/L) mice versus Cbs+/+ (3.1+-0.6 mumol/L) mice.	Homocysteine	41-53	cystathionine beta-synthase	Mus musculus	70-73
32820455-2	2021	The sex hormone estrogen (E2) modulates gene expression and redox balance in some tissues by inducing the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Estradiol	26-28	cystathionine beta-synthase	Mus musculus	131-158
32820455-2	2021	The sex hormone estrogen (E2) modulates gene expression and redox balance in some tissues by inducing the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Estradiol	26-28	cystathionine beta-synthase	Mus musculus	160-163
32820455-5	2021	In ovariectomized mice, exogenous E2 upregulates CBS and downregulates CSE levels.	Estradiol	34-36	cystathionine beta-synthase	Mus musculus	49-52
32820455-6	2021	E2 promotes CBS mRNA and protein expression but attenuates CSE protein expression without affecting CSE mRNA.	Estradiol	0-2	cystathionine beta-synthase	Mus musculus	12-15
33318875-7	2021	Double-silencing of endogenous H2S producing enzymes, Cystathionine gamma-lyase (CSE) and Cystathionine beta-synthase (CBS) in VIC exerted enhanced mineralization and higher levels of IL-1beta and TNF-alpha.	Deuterium	31-34	cystathionine beta-synthase	Mus musculus	119-122
33318875-14	2021	Our study suggests that the regulation of Runx2 by hydrogen sulfide (CSE/CBS) occurs via NF-kappaB establishing a link between inflammation and mineralization in vascular calcification.	Hydrogen Sulfide	51-67	cystathionine beta-synthase	Mus musculus	73-76
32027885-2	2020	Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	74-77	cystathionine beta-synthase	Mus musculus	119-146
32027885-2	2020	Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	74-77	cystathionine beta-synthase	Mus musculus	148-151
31516045-6	2020	Interestingly, the levels of H2S and cystathionine-gamma-lyase were significantly low in IVF-derived mice in basal conditions also, i.e. before subjecting to I/R injury and these biochemical alterations were associated with the behavioural deficits in mice, even before subjecting to I/R injury.Conclusion: It is concluded that in vitro fertilization-derived mice are more susceptible to global cerebral I/R injury, which may be possibly due to decreased levels of hydrogen sulphide and its biosynthetic enzymes viz., cystathionine-beta-synthase and cystathionine-gamma-lyase.	Deuterium	29-32	cystathionine beta-synthase	Mus musculus	518-545
32260476-1	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway.	Homocysteine	96-108	cystathionine beta-synthase	Mus musculus	0-27
32260476-1	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway.	Homocysteine	96-108	cystathionine beta-synthase	Mus musculus	29-32
32260476-1	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway.	Cysteine	100-108	cystathionine beta-synthase	Mus musculus	0-27
32260476-1	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway.	Cysteine	100-108	cystathionine beta-synthase	Mus musculus	29-32
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Metformin	121-130	cystathionine beta-synthase	Mus musculus	55-82
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Metformin	121-130	cystathionine beta-synthase	Mus musculus	84-87
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Metformin	193-202	cystathionine beta-synthase	Mus musculus	55-82
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Metformin	193-202	cystathionine beta-synthase	Mus musculus	84-87
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	ampkalpha	215-224	cystathionine beta-synthase	Mus musculus	84-87
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Glucose	268-275	cystathionine beta-synthase	Mus musculus	84-87
32006903-6	2020	Consistent with an antagonistic effect, puerarin induced mRNA and protein expressions of Bhmt, Cbs and Cth (three enzymes involved in homocysteine catabolism and known targets of Rev-erbalpha) in Hepa-1c1c7 cells.	puerarin	40-48	cystathionine beta-synthase	Mus musculus	95-98
32067580-3	2020	Mild or severe elevation in plasma total homocysteine was observed in Cbs+/- (6.1+-0.3 mumol/L) or Cbs-/- (309+-18 mumol/L) mice versus Cbs+/+ (3.1+-0.6 mumol/L) mice.	Homocysteine	41-53	cystathionine beta-synthase	Mus musculus	99-102
32067580-3	2020	Mild or severe elevation in plasma total homocysteine was observed in Cbs+/- (6.1+-0.3 mumol/L) or Cbs-/- (309+-18 mumol/L) mice versus Cbs+/+ (3.1+-0.6 mumol/L) mice.	Homocysteine	41-53	cystathionine beta-synthase	Mus musculus	99-102
32067580-4	2020	Surprisingly, Cbs-/- and Cbs+/- mice exhibited similar increases in cerebral infarct size following middle cerebral artery ischemia/reperfusion injury, despite the much higher total homocysteine levels in Cbs-/- mice.	Homocysteine	182-194	cystathionine beta-synthase	Mus musculus	14-17
32067580-6	2020	Administration of the N-methyl-D-aspartate receptor antagonist memantine protected Cbs+/- but not Cbs-/- mice from cerebral infarction and blood brain barrier disruption.	N-Methylaspartate	22-42	cystathionine beta-synthase	Mus musculus	83-86
32067580-6	2020	Administration of the N-methyl-D-aspartate receptor antagonist memantine protected Cbs+/- but not Cbs-/- mice from cerebral infarction and blood brain barrier disruption.	Memantine	63-72	cystathionine beta-synthase	Mus musculus	83-86
32067580-7	2020	Our data suggest that the differential effect of memantine in Cbs+/- versus Cbs-/- mice may be related to changes in expression of N-methyl-D-aspartate receptor subunits.	Memantine	49-58	cystathionine beta-synthase	Mus musculus	62-65
32067580-7	2020	Our data suggest that the differential effect of memantine in Cbs+/- versus Cbs-/- mice may be related to changes in expression of N-methyl-D-aspartate receptor subunits.	Memantine	49-58	cystathionine beta-synthase	Mus musculus	76-79
32067580-7	2020	Our data suggest that the differential effect of memantine in Cbs+/- versus Cbs-/- mice may be related to changes in expression of N-methyl-D-aspartate receptor subunits.	N-Methylaspartate	131-151	cystathionine beta-synthase	Mus musculus	62-65
32067580-7	2020	Our data suggest that the differential effect of memantine in Cbs+/- versus Cbs-/- mice may be related to changes in expression of N-methyl-D-aspartate receptor subunits.	N-Methylaspartate	131-151	cystathionine beta-synthase	Mus musculus	76-79
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Hydrogen Sulfide	14-17	cystathionine beta-synthase	Mus musculus	76-103
30799778-0	2019	Cystathionine beta-Synthase-Derived Hydrogen Sulfide Correlates with Successful Aging in Mice.	Hydrogen Sulfide	36-52	cystathionine beta-synthase	Mus musculus	0-27
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Cysteine	138-148	cystathionine beta-synthase	Mus musculus	95-122
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Cysteine	138-148	cystathionine beta-synthase	Mus musculus	124-127
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Serine	154-162	cystathionine beta-synthase	Mus musculus	95-122
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Serine	154-162	cystathionine beta-synthase	Mus musculus	124-127
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Hydrogen Sulfide	167-171	cystathionine beta-synthase	Mus musculus	95-122
30835815-1	2020	BACKGROUND AND PURPOSE: Among the three enzymes involved in the transsulfuration pathway, only cystathionine beta-synthase (CBS) converts L-cysteine into L-serine and H2 S.	Hydrogen Sulfide	167-171	cystathionine beta-synthase	Mus musculus	124-127
30835815-13	2020	CONCLUSIONS AND IMPLICATIONS: L-serine, a by-product formed within the transsulfuration pathway starting from L-cysteine via CBS, contributes to the vasodilator action of L-cysteine.	Serine	30-38	cystathionine beta-synthase	Mus musculus	125-128
30835815-13	2020	CONCLUSIONS AND IMPLICATIONS: L-serine, a by-product formed within the transsulfuration pathway starting from L-cysteine via CBS, contributes to the vasodilator action of L-cysteine.	Cysteine	171-181	cystathionine beta-synthase	Mus musculus	125-128
31539805-7	2020	S-adenosylmethionine administration enhanced Nos2 mRNA expression and cystathionine beta-synthase nitration and triggered homocysteine accumulation in acute pancreatitis.	S-Adenosylmethionine	0-20	cystathionine beta-synthase	Mus musculus	70-97
31539805-10	2020	In conclusion, tyrosine-nitration of cystathionine beta-synthase blockades the trans-sulfuration pathway in acute pancreatitis promoting homocysteine accumulation upon S-adenosylmethionine treatment.	Tyrosine	15-23	cystathionine beta-synthase	Mus musculus	37-64
31539805-10	2020	In conclusion, tyrosine-nitration of cystathionine beta-synthase blockades the trans-sulfuration pathway in acute pancreatitis promoting homocysteine accumulation upon S-adenosylmethionine treatment.	Homocysteine	137-149	cystathionine beta-synthase	Mus musculus	37-64
31539805-10	2020	In conclusion, tyrosine-nitration of cystathionine beta-synthase blockades the trans-sulfuration pathway in acute pancreatitis promoting homocysteine accumulation upon S-adenosylmethionine treatment.	S-Adenosylmethionine	168-188	cystathionine beta-synthase	Mus musculus	37-64
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	propargylglycine	137-153	cystathionine beta-synthase	Mus musculus	76-103
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	oxyaminoacetic acid	164-183	cystathionine beta-synthase	Mus musculus	76-103
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Aminooxyacetic Acid	185-189	cystathionine beta-synthase	Mus musculus	76-103
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	Hydrogen Sulfide	205-208	cystathionine beta-synthase	Mus musculus	76-103
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	1-propenyl persulfide	326-347	cystathionine beta-synthase	Mus musculus	76-103
31349040-9	2019	Inhibition of H2S-synthesizing enzymes, cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), by pretreating cells with propargylglycine (PAG) and oxyaminoacetic acid (AOAA) revealed that H2S production was partially dependent on a CSE/CBS-catalyzed beta-elimination reaction with CySSPe that likely produced 1-propenyl persulfide (RSSH).	rssh	349-353	cystathionine beta-synthase	Mus musculus	76-103
31343254-4	2019	H2S was measured with a specific fluorophore (7-azido-3-methylcoumarin) in intact MSCs and in cells with the H2S-producing enzyme cystathionine beta synthase (CBS) knocked down with siRNA.	Deuterium	0-3	cystathionine beta-synthase	Mus musculus	130-157
31343254-4	2019	H2S was measured with a specific fluorophore (7-azido-3-methylcoumarin) in intact MSCs and in cells with the H2S-producing enzyme cystathionine beta synthase (CBS) knocked down with siRNA.	Deuterium	109-112	cystathionine beta-synthase	Mus musculus	130-157
31343254-7	2019	Knockdown of CBS in MSCs decreased H2S production by MSCs and also decreased MSC-initiated MA dilation.	Deuterium	35-38	cystathionine beta-synthase	Mus musculus	13-16
31283913-4	2019	129P2-Cbstm1Unc/J mice with heterozygous mutants in H2S generating enzyme cystathionine beta-synthase were used to study the effect of endogenous H2S.	Hydrogen Sulfide	52-55	cystathionine beta-synthase	Mus musculus	74-101
31551410-0	2019	Cystathionine beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.	Heme	99-103	cystathionine beta-synthase	Mus musculus	0-27
31551410-0	2019	Cystathionine beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.	Heme	99-103	cystathionine beta-synthase	Mus musculus	29-32
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	12-16	cystathionine beta-synthase	Mus musculus	118-121
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	12-16	cystathionine beta-synthase	Mus musculus	132-135
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	101-105	cystathionine beta-synthase	Mus musculus	118-121
31551410-1	2019	The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice.	Iron	101-105	cystathionine beta-synthase	Mus musculus	132-135
31084364-1	2019	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by extremely elevated total homocysteine (tHcy) in the blood.	Homocysteine	129-141	cystathionine beta-synthase	Mus musculus	0-27
31084364-1	2019	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by extremely elevated total homocysteine (tHcy) in the blood.	thcy	143-147	cystathionine beta-synthase	Mus musculus	0-27
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	99-102
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	172-175
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	22-25
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	22-25
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	Homocysteine	78-90	cystathionine beta-synthase	Mus musculus	22-25
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	191-194
30912146-8	2019	Our results demonstrated that administration of Hcy increases the intracellular Hcy level and decreases intracellular H2 S level and expression of the cystathionine beta-synthase/Cystathionine gamma-lyase system, thereby inhibiting osteogenic differentiation.	Homocysteine	48-51	cystathionine beta-synthase	Mus musculus	151-178
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Bortezomib	65-75	cystathionine beta-synthase	Mus musculus	22-25
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Bortezomib	65-75	cystathionine beta-synthase	Mus musculus	191-194
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	183-185	cystathionine beta-synthase	Mus musculus	22-25
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	92-96	cystathionine beta-synthase	Mus musculus	22-25
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	108-112	cystathionine beta-synthase	Mus musculus	22-25
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	41-44
31119834-2	2019	H2 S production in colon is yielded by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) enzymes and sulfate-reducing bacteria (SRB).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Mus musculus	39-66
31119834-2	2019	H2 S production in colon is yielded by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) enzymes and sulfate-reducing bacteria (SRB).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Mus musculus	68-71
31440142-4	2019	We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain.	Hydrogen Sulfide	25-28	cystathionine beta-synthase	Mus musculus	117-144
31440142-4	2019	We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain.	Hydrogen Sulfide	25-28	cystathionine beta-synthase	Mus musculus	146-149
31440142-4	2019	We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain.	Hydrogen Sulfide	179-182	cystathionine beta-synthase	Mus musculus	117-144
31440142-4	2019	We found that endogenous H2S production was downregulated in the brain after ICH, which is caused by the decrease in cystathionine beta-synthase (CBS) as the predominant cerebral H2S-generating enzyme in the brain.	Hydrogen Sulfide	179-182	cystathionine beta-synthase	Mus musculus	146-149
31440142-5	2019	Treatment with sodium hydrosulfide (NaHS; an H2S producer) could restore the H2S production and the expression of CBS.	sodium bisulfide	15-34	cystathionine beta-synthase	Mus musculus	114-117
31440142-5	2019	Treatment with sodium hydrosulfide (NaHS; an H2S producer) could restore the H2S production and the expression of CBS.	sodium bisulfide	36-40	cystathionine beta-synthase	Mus musculus	114-117
31440142-5	2019	Treatment with sodium hydrosulfide (NaHS; an H2S producer) could restore the H2S production and the expression of CBS.	Hydrogen Sulfide	45-48	cystathionine beta-synthase	Mus musculus	114-117
31440142-8	2019	However, H2S could not restore brain CBS expression and H2S content, reduce brain edema, and improve motor performance and memory function after ICH through modulating autophagy and apoptosis when pretreated with the CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	231-250	cystathionine beta-synthase	Mus musculus	217-220
31440142-9	2019	We also found that AOAA reduced the endogenous H2S production through inhibiting the enzyme activity of CBS rather than modulating the expression of CBS protein level.	Hydrogen Sulfide	47-50	cystathionine beta-synthase	Mus musculus	104-107
30238388-0	2019	Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain.	Serotonin	19-28	cystathionine beta-synthase	Mus musculus	54-81
31025223-4	2019	Biochemically, there was increase in the plasma levels of endothelin-1 along with increase in the brain levels of H2S and its biosynthetic enzymes viz., cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CLS).	Hydrogen Sulfide	114-117	cystathionine beta-synthase	Mus musculus	153-180
30238388-0	2019	Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain.	Dopamine	33-41	cystathionine beta-synthase	Mus musculus	54-81
30238388-6	2019	Briefly, the serotonin pathway was modified by CBS overexpression in various brain areas in female mice but not in male mice.	Serotonin	13-22	cystathionine beta-synthase	Mus musculus	47-50
31178749-10	2019	Additionally, SG1002 treatment increased end-diastolic volume and SV in CBS+/- mice, suggesting increased ventricular filling.	sg1002	14-20	cystathionine beta-synthase	Mus musculus	72-75
30862476-3	2019	Therefore we assessed the expressional kinetics of potential H2S-producing enzymes during undisturbed skin repair: the cystathionine-gamma-lyase (CSE), the cystathionine-beta-synthase (CBS) and the 3-mercaptopyruvate sulfurtransferase (MPST).	Hydrogen Sulfide	61-64	cystathionine beta-synthase	Mus musculus	185-188
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	0-20	cystathionine beta-synthase	Mus musculus	56-83
31137614-5	2019	Amino-oxyacetic acid (AOA)-a systemic dual inhibitor of cystathionine-beta-synthase and cystathionine-gamma lyase (two key enzymes in the production of H2S)-was administered to fALS mice.	Aminooxyacetic Acid	22-25	cystathionine beta-synthase	Mus musculus	56-83
30859447-1	2019	Murine macrophages of the J774A.1 line are hydrogen sulphide-producing cells with the primary role of gamma-cystathionase (CTH) and secondary role of 3-mercaptopyruvate sulfurtransferase (limited by cysteine availability) and with a negligible role of cystathionine beta-synthase (CBS) in H2S generation.	Hydrogen Sulfide	43-60	cystathionine beta-synthase	Mus musculus	252-279
30768359-0	2019	Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	165-192
31131233-0	2019	Hydrogen sulfide intervention in cystathionine-beta-synthase mutant mouse helps restore ocular homeostasis.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	33-60
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Methionine	68-78	cystathionine beta-synthase	Mus musculus	9-12
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Methionine	68-78	cystathionine beta-synthase	Mus musculus	25-28
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Homocysteine	79-91	cystathionine beta-synthase	Mus musculus	9-12
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Homocysteine	79-91	cystathionine beta-synthase	Mus musculus	25-28
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Homocysteine	93-96	cystathionine beta-synthase	Mus musculus	9-12
31131233-6	2019	RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.	Homocysteine	93-96	cystathionine beta-synthase	Mus musculus	25-28
31131233-9	2019	Increased glutamate levels in CBS+/- strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment.	Glutamic Acid	10-19	cystathionine beta-synthase	Mus musculus	30-33
31131233-9	2019	Increased glutamate levels in CBS+/- strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment.	GYY 4137	133-140	cystathionine beta-synthase	Mus musculus	30-33
31131233-11	2019	Interestingly, GYY4137 was able to improve CBS+/- mice behavior together with lowering their glutamate levels.	GYY 4137	15-22	cystathionine beta-synthase	Mus musculus	43-46
31131233-12	2019	Blood-retinal barrier (BRB) appeared compromised in CBS+/- with vessels" leakage that was mitigated in GYY4137 treated group.	GYY 4137	103-110	cystathionine beta-synthase	Mus musculus	52-55
30768359-10	2019	Collectively, our findings indicate that adjuvantial taurine treatment has the potential to significantly improve clinical outcomes in HCU.-Maclean, K. N., Jiang, H, Phinney, W. N., Keating, A. K., Hurt, K. J., Stabler, S. P. Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.	Taurine	53-60	cystathionine beta-synthase	Mus musculus	391-418
30683311-2	2019	Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs.	Hydrogen Sulfide	38-41	cystathionine beta-synthase	Mus musculus	0-27
30260040-8	2019	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) systems were the endogenous pathway of H 2 S. The expression of CBS/CSE was decreased in APAP-treated mice, while H 2 S could significantly restore it.	Acetaminophen	159-163	cystathionine beta-synthase	Mus musculus	0-27
30260040-8	2019	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) systems were the endogenous pathway of H 2 S. The expression of CBS/CSE was decreased in APAP-treated mice, while H 2 S could significantly restore it.	Acetaminophen	159-163	cystathionine beta-synthase	Mus musculus	29-32
30260040-8	2019	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) systems were the endogenous pathway of H 2 S. The expression of CBS/CSE was decreased in APAP-treated mice, while H 2 S could significantly restore it.	Acetaminophen	159-163	cystathionine beta-synthase	Mus musculus	134-141
30683311-2	2019	Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs.	Hydrogen Sulfide	38-41	cystathionine beta-synthase	Mus musculus	29-32
30683311-2	2019	Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs.	Methionine	63-73	cystathionine beta-synthase	Mus musculus	0-27
30683311-2	2019	Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs.	Methionine	63-73	cystathionine beta-synthase	Mus musculus	29-32
30683311-11	2019	The administration of 5-Aza in HMD mice restored the CBS expression, EPC mediated angiogenesis and blood flow by reducing abnormal DNA hyper-methylation.	Azacitidine	22-27	cystathionine beta-synthase	Mus musculus	53-56
30345292-7	2018	The accumulation of N-Hcy in hair keratin led to a progressive reduction of N-Hcy-keratin solubility in sodium dodecyl sulfate, from 0.39 +- 0.04 in wild-type mice to 0.19 +- 0.03, 0.14 +- 0.01, and 0.07 +- 0.03 in Mthfr -/-, Cse -/-, or Cbs -/-animals, respectively.	n-hcy	20-25	cystathionine beta-synthase	Mus musculus	238-241
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Hydrogen Sulfide	121-124	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Hydrogen Sulfide	121-124	cystathionine beta-synthase	Mus musculus	84-87
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	propargylglycine	142-158	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	propargylglycine	142-158	cystathionine beta-synthase	Mus musculus	84-87
29486221-5	2018	The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Mus musculus	26-53
29486221-5	2018	The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Mus musculus	55-58
29486221-5	2018	The H2S-generating enzyme cystathionine-beta-synthase (CBS) knockout heterozygous (CBS+/-) mice showed mitochondria-mediated apoptosis in the adrenal gland and adrenal insufficiency.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Mus musculus	83-86
29486221-9	2018	The level of S-sulfhydrated ATP5A1 was decreased in the adrenal gland of endotoxemic and CBS+/- mice, which was restored by GYY4137.	GYY 4137	124-131	cystathionine beta-synthase	Mus musculus	89-92
30136377-11	2019	Moreover, exercise training restored bleomycin-induced downregulation of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) expression, as well as H2 S generation in lung tissue (P < 0.01).	Bleomycin	37-46	cystathionine beta-synthase	Mus musculus	73-100
30534696-7	2019	Meanwhile, the decreased cystathionine beta synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level was also observed in H22-bearing mice admistrated with the combination of curcuma zedoary and kelp.	Hydrogen Sulfide	73-89	cystathionine beta-synthase	Mus musculus	25-52
30534696-7	2019	Meanwhile, the decreased cystathionine beta synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level was also observed in H22-bearing mice admistrated with the combination of curcuma zedoary and kelp.	Hydrogen Sulfide	73-89	cystathionine beta-synthase	Mus musculus	54-57
30534696-10	2019	Our previous research showed that a CBS/H2S system was vital for maintaining the proliferation in hepatoma cells.	Hydrogen Sulfide	40-43	cystathionine beta-synthase	Mus musculus	36-39
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	ppg	160-163	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	ppg	160-163	cystathionine beta-synthase	Mus musculus	84-87
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	169-185	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	169-185	cystathionine beta-synthase	Mus musculus	84-87
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	187-191	cystathionine beta-synthase	Mus musculus	55-82
30036087-4	2019	Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for endogenous H2S production, with propargylglycine (PPG) and amino-oxyacetate (AOAA), respectively, caused increased urine output and reduced urine osmolality in mice that was associated with decreased expression of aquaporin (AQP)-2 in the renal inner medulla.	Aminooxyacetic Acid	187-191	cystathionine beta-synthase	Mus musculus	84-87
30345292-7	2018	The accumulation of N-Hcy in hair keratin led to a progressive reduction of N-Hcy-keratin solubility in sodium dodecyl sulfate, from 0.39 +- 0.04 in wild-type mice to 0.19 +- 0.03, 0.14 +- 0.01, and 0.07 +- 0.03 in Mthfr -/-, Cse -/-, or Cbs -/-animals, respectively.	Nitrogen	20-21	cystathionine beta-synthase	Mus musculus	238-241
30345292-7	2018	The accumulation of N-Hcy in hair keratin led to a progressive reduction of N-Hcy-keratin solubility in sodium dodecyl sulfate, from 0.39 +- 0.04 in wild-type mice to 0.19 +- 0.03, 0.14 +- 0.01, and 0.07 +- 0.03 in Mthfr -/-, Cse -/-, or Cbs -/-animals, respectively.	Homocysteine	22-25	cystathionine beta-synthase	Mus musculus	238-241
30030379-1	2018	Mutations in the cystathionine beta-synthase (CBS) gene are the cause of classical homocystinuria, the most common inborn error in sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Mus musculus	17-44
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	92-95
30030379-1	2018	Mutations in the cystathionine beta-synthase (CBS) gene are the cause of classical homocystinuria, the most common inborn error in sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Mus musculus	46-49
28982640-1	2018	Hydrogen sulfide (H2S) is an endogenously produced signaling molecule synthesized by cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	118-145
29730290-1	2018	Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), influences bone remodeling in many ways.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	101-128
29730290-1	2018	Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), influences bone remodeling in many ways.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	101-128
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Serine	49-55	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Serine	49-55	cystathionine beta-synthase	Mus musculus	29-32
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Homocysteine	121-133	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Homocysteine	121-133	cystathionine beta-synthase	Mus musculus	29-32
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Homocysteine	135-138	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Homocysteine	135-138	cystathionine beta-synthase	Mus musculus	29-32
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Pyridoxal Phosphate	143-165	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Pyridoxal Phosphate	143-165	cystathionine beta-synthase	Mus musculus	29-32
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Cystathionine	180-193	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Cystathionine	180-193	cystathionine beta-synthase	Mus musculus	29-32
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Cysteine	125-133	cystathionine beta-synthase	Mus musculus	0-27
29803556-1	2018	Cystathionine-beta-synthase (CBS) gene encodes L-serine hydrolyase which catalyzes beta-reaction to condense serine with homocysteine (Hcy) by pyridoxal-5"-phosphate helps to form cystathionine which in turn is converted to cysteine.	Cysteine	125-133	cystathionine beta-synthase	Mus musculus	29-32
29803556-2	2018	CBS resides at the intersection of transmethylation, transsulfuration, and remethylation pathways, thus lack of CBS fundamentally blocks Hcy degradation; an essential step in glutathione synthesis.	Glutathione	175-186	cystathionine beta-synthase	Mus musculus	0-3
29803556-2	2018	CBS resides at the intersection of transmethylation, transsulfuration, and remethylation pathways, thus lack of CBS fundamentally blocks Hcy degradation; an essential step in glutathione synthesis.	Glutathione	175-186	cystathionine beta-synthase	Mus musculus	112-115
29803556-3	2018	Redox homeostasis, free-radical detoxification and one-carbon metabolism (Methionine-Hcy-Folate cycle) require CBS and its deficiency leads to hyperhomocysteinemia (HHcy) causing retinovascular thromboembolism and eye-lens dislocation along with vascular cognitive impairment and dementia.	Carbon	55-61	cystathionine beta-synthase	Mus musculus	111-114
29803556-3	2018	Redox homeostasis, free-radical detoxification and one-carbon metabolism (Methionine-Hcy-Folate cycle) require CBS and its deficiency leads to hyperhomocysteinemia (HHcy) causing retinovascular thromboembolism and eye-lens dislocation along with vascular cognitive impairment and dementia.	methionine-hcy-folate	74-95	cystathionine beta-synthase	Mus musculus	111-114
30175474-0	2018	Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-beta-synthase mutant mice via PPAR-gamma/VEGF axis.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	75-102
29998554-2	2018	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are the major enzymes responsible for H2 S production through desulfuration reactions.	Hydrogen Sulfide	108-112	cystathionine beta-synthase	Mus musculus	0-27
29998554-2	2018	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are the major enzymes responsible for H2 S production through desulfuration reactions.	Hydrogen Sulfide	108-112	cystathionine beta-synthase	Mus musculus	29-32
29635516-8	2018	These changes were associated with alterations in SAM-dependent methylation pathways and expression of the enzymes methionine adenosyltransferase 2A and cystathionine beta synthase.	Methionine	115-125	cystathionine beta-synthase	Mus musculus	153-180
28605831-8	2018	The hepatic changes in homocysteine and cysteine may be attributed to upregulation of cystathionine beta-synthase and down-regulation of gamma-glutamylcysteine ligase in the aged mice.	Homocysteine	23-35	cystathionine beta-synthase	Mus musculus	86-113
28605831-8	2018	The hepatic changes in homocysteine and cysteine may be attributed to upregulation of cystathionine beta-synthase and down-regulation of gamma-glutamylcysteine ligase in the aged mice.	Cysteine	27-35	cystathionine beta-synthase	Mus musculus	86-113
28774789-5	2018	Interestingly, among the three H2S generating enzymes, only cystathionine beta-synthase (CBS) expression was largely reduced in the striatum of MPTP-treated mice.	Deuterium	31-34	cystathionine beta-synthase	Mus musculus	60-87
28774789-5	2018	Interestingly, among the three H2S generating enzymes, only cystathionine beta-synthase (CBS) expression was largely reduced in the striatum of MPTP-treated mice.	Deuterium	31-34	cystathionine beta-synthase	Mus musculus	89-92
28774789-5	2018	Interestingly, among the three H2S generating enzymes, only cystathionine beta-synthase (CBS) expression was largely reduced in the striatum of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	144-148	cystathionine beta-synthase	Mus musculus	60-87
28774789-5	2018	Interestingly, among the three H2S generating enzymes, only cystathionine beta-synthase (CBS) expression was largely reduced in the striatum of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	144-148	cystathionine beta-synthase	Mus musculus	89-92
28774789-8	2018	Specifically, striatal CBS overexpression alleviated the motor deficits and dopaminergic neuron losses in the nigro-striatal pathway, with a concomitant inhibition of glial activation in MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	187-191	cystathionine beta-synthase	Mus musculus	23-26
28774789-9	2018	Furthermore, compared to rAAV-Vector, rAAV-Cbs injection reduced the aberrant accumulation of nitric oxide and 3-nitrotyrosine (an indicator of protein nitration) in the striatum of MPTP-treated mice.	Nitric Oxide	94-106	cystathionine beta-synthase	Mus musculus	43-46
28774789-9	2018	Furthermore, compared to rAAV-Vector, rAAV-Cbs injection reduced the aberrant accumulation of nitric oxide and 3-nitrotyrosine (an indicator of protein nitration) in the striatum of MPTP-treated mice.	3-nitrotyrosine	111-126	cystathionine beta-synthase	Mus musculus	43-46
28774789-9	2018	Furthermore, compared to rAAV-Vector, rAAV-Cbs injection reduced the aberrant accumulation of nitric oxide and 3-nitrotyrosine (an indicator of protein nitration) in the striatum of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	182-186	cystathionine beta-synthase	Mus musculus	43-46
28774789-11	2018	The in vitro study demonstrated that lentivirus-mediated CBS overexpression elevated the sulfide generation in glial cells.	Sulfides	89-96	cystathionine beta-synthase	Mus musculus	57-60
28774789-12	2018	Moreover, glial CBS overexpression offered protection to midbrain dopaminergic neurons through repressing nitric oxide overproduction in both glial and neuronal cells induced by MPP+.	Nitric Oxide	106-118	cystathionine beta-synthase	Mus musculus	16-19
28774789-12	2018	Moreover, glial CBS overexpression offered protection to midbrain dopaminergic neurons through repressing nitric oxide overproduction in both glial and neuronal cells induced by MPP+.	mangion-purified polysaccharide (Candida albicans)	178-182	cystathionine beta-synthase	Mus musculus	16-19
28774789-13	2018	Taken together, our data suggest that impaired CBS-H2S axis may contribute to the pathogenesis of PD, and that modulation of this axis may become a novel therapeutic approach for PD.	Deuterium	51-54	cystathionine beta-synthase	Mus musculus	47-50
29255346-4	2017	The present study aimed to evaluate the effects and potential mechanism(s) of action of CBS on mice with fructose-induced nonalcoholic fatty liver disease (NAFLD).	Fructose	105-113	cystathionine beta-synthase	Mus musculus	88-91
28859237-0	2018	Cystathionine beta-synthase is required for body iron homeostasis.	Iron	49-53	cystathionine beta-synthase	Mus musculus	0-27
28859237-1	2018	Cystathionine beta-synthase (CBS) catalyzes the transsulfuration pathway and contributes, among other functions, to the generation of hydrogen sulfide.	Hydrogen Sulfide	134-150	cystathionine beta-synthase	Mus musculus	0-27
28859237-1	2018	Cystathionine beta-synthase (CBS) catalyzes the transsulfuration pathway and contributes, among other functions, to the generation of hydrogen sulfide.	Hydrogen Sulfide	134-150	cystathionine beta-synthase	Mus musculus	29-32
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Hydrogen Sulfide	136-152	cystathionine beta-synthase	Mus musculus	185-188
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	cystathionine beta-synthase	Mus musculus	48-51
28859237-2	2018	In view of the exceptionally high expression of CBS in the liver and the common interleukin-6 pathway used in the regulatory systems of hydrogen sulfide and hepcidin, we speculate that CBS is involved in body iron homeostasis.	Iron	209-213	cystathionine beta-synthase	Mus musculus	185-188
28859237-3	2018	We found that CBS knockout (CBS-/- ) mice exhibited anemia and a significant increase in iron content in the serum, liver, spleen, and heart, along with severe damage to the liver, displaying a hemochromatosis-like phenotype.	Iron	89-93	cystathionine beta-synthase	Mus musculus	14-17
28859237-3	2018	We found that CBS knockout (CBS-/- ) mice exhibited anemia and a significant increase in iron content in the serum, liver, spleen, and heart, along with severe damage to the liver, displaying a hemochromatosis-like phenotype.	Iron	89-93	cystathionine beta-synthase	Mus musculus	28-31
28859237-6	2018	Importantly, in the liver, absence of CBS caused both a reduction in the transcriptional factor nuclear factor erythroid 2-related factor-2 and an up-regulation of hepcidin that led to a decrease in the iron export protein ferroportin 1.	Iron	203-207	cystathionine beta-synthase	Mus musculus	38-41
28859237-8	2018	Finally, administration of CBS-overexpressing adenovirus into CBS mutant mice could partially reverse the iron-related phenotype.	Iron	106-110	cystathionine beta-synthase	Mus musculus	27-30
28859237-8	2018	Finally, administration of CBS-overexpressing adenovirus into CBS mutant mice could partially reverse the iron-related phenotype.	Iron	106-110	cystathionine beta-synthase	Mus musculus	62-65
29255346-7	2017	Treatment with CBS reversed the fructose-induced impaired glucose tolerance.	Fructose	32-40	cystathionine beta-synthase	Mus musculus	15-18
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Fructose	70-78	cystathionine beta-synthase	Mus musculus	136-139
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Carboxymethylcellulose Sodium	104-134	cystathionine beta-synthase	Mus musculus	136-139
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Glucose	202-209	cystathionine beta-synthase	Mus musculus	136-139
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Triglycerides	228-240	cystathionine beta-synthase	Mus musculus	136-139
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Cholesterol	252-263	cystathionine beta-synthase	Mus musculus	136-139
29255346-9	2017	CBS treatment also significantly decreased the levels of triglyceride, total cholesterol, and free fatty acid in the liver.	Triglycerides	57-69	cystathionine beta-synthase	Mus musculus	0-3
29255346-9	2017	CBS treatment also significantly decreased the levels of triglyceride, total cholesterol, and free fatty acid in the liver.	Cholesterol	77-88	cystathionine beta-synthase	Mus musculus	0-3
29255346-9	2017	CBS treatment also significantly decreased the levels of triglyceride, total cholesterol, and free fatty acid in the liver.	Fatty Acids, Nonesterified	94-109	cystathionine beta-synthase	Mus musculus	0-3
29255346-10	2017	The activity of superoxide dismutase in the liver was increased after treatment with CBS, however, levels of malondialdehyde and reactive oxygen species decreased.	Malondialdehyde	109-124	cystathionine beta-synthase	Mus musculus	85-88
29255346-10	2017	The activity of superoxide dismutase in the liver was increased after treatment with CBS, however, levels of malondialdehyde and reactive oxygen species decreased.	Reactive Oxygen Species	129-152	cystathionine beta-synthase	Mus musculus	85-88
28821635-1	2017	Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.	Homocysteine	181-193	cystathionine beta-synthase	Mus musculus	114-141
28121025-4	2017	In our previous in vivo study, impaired expression in MSCs of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), the two key enzymes in the catabolic pathway of homocysteine, was associated to decreased bone formation and to the onset of osteoporosis in mice.	Homocysteine	181-193	cystathionine beta-synthase	Mus musculus	62-89
28121025-4	2017	In our previous in vivo study, impaired expression in MSCs of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), the two key enzymes in the catabolic pathway of homocysteine, was associated to decreased bone formation and to the onset of osteoporosis in mice.	Homocysteine	181-193	cystathionine beta-synthase	Mus musculus	91-94
28821635-1	2017	Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.	Homocysteine	181-193	cystathionine beta-synthase	Mus musculus	143-146
28821635-1	2017	Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.	Cystathionine	114-127	cystathionine beta-synthase	Mus musculus	143-146
28821635-1	2017	Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.	Cysteine	185-193	cystathionine beta-synthase	Mus musculus	114-141
28821635-1	2017	Classical homocystinuria (HCU) is an inborn error of sulfur amino acid metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.	Cysteine	185-193	cystathionine beta-synthase	Mus musculus	143-146
28665886-8	2017	CBS+/- mice aorta had lower response to phenylephrine and acetylcholine compared with other groups; however, CBS+/-/C3H mice response was improved.	Phenylephrine	40-53	cystathionine beta-synthase	Mus musculus	0-3
28665886-8	2017	CBS+/- mice aorta had lower response to phenylephrine and acetylcholine compared with other groups; however, CBS+/-/C3H mice response was improved.	Acetylcholine	58-71	cystathionine beta-synthase	Mus musculus	0-3
28665886-10	2017	In addition, CBS+/- mice showed increased oxidative stress, inflammation and decreased nitric oxide.	Nitric Oxide	87-99	cystathionine beta-synthase	Mus musculus	13-16
28847570-5	2017	Furthermore, acetylcholine-induced relaxations were attenuated by cystathionine-gamma-lyase (CSE) inhibitor d,l-propargylglycine (PAG, 10-2 M) and cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-3 M).	Acetylcholine	13-26	cystathionine beta-synthase	Mus musculus	147-174
28759161-5	2017	However, when cystathionine beta-synthase expression was inhibited by interference RNA in hepatocytes, the effects of serine supplementation on the improvement of glutathione synthesis and the alleviation of oxidative stress were diminished.	Serine	118-124	cystathionine beta-synthase	Mus musculus	14-41
28759161-5	2017	However, when cystathionine beta-synthase expression was inhibited by interference RNA in hepatocytes, the effects of serine supplementation on the improvement of glutathione synthesis and the alleviation of oxidative stress were diminished.	Glutathione	163-174	cystathionine beta-synthase	Mus musculus	14-41
28488385-1	2017	Mutations in the cystathionine beta-synthase (CBS) gene are the cause of classical homocystinuria, the most common inborn error in sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Mus musculus	17-44
28158949-6	2017	MsrA gene deletion exacerbated cisplatin-induced reductions in the expression and activity of MsrA and MsrBs, and the expression of thioredoxin 1, glutathione peroxidase 1 and 4, mitochondrial superoxide dismutase, cystathionine-beta-synthase, and cystathionine-gamma-lyase.	Cisplatin	31-40	cystathionine beta-synthase	Mus musculus	215-242
28735240-9	2017	Importantly, pre-treatment with a CBS inhibitor significantly attenuated the neuroprotection of L-Cysteine on HI insult.	Cysteine	96-106	cystathionine beta-synthase	Mus musculus	34-37
28735240-10	2017	Thus, L-Cysteine exerts neuroprotection against HI-induced injury in neonates via the CBS/H2S pathway, mediated in part by anti-apoptotic effects and reduced oxidative stress and ER stress.	Cysteine	6-16	cystathionine beta-synthase	Mus musculus	86-89
28735240-10	2017	Thus, L-Cysteine exerts neuroprotection against HI-induced injury in neonates via the CBS/H2S pathway, mediated in part by anti-apoptotic effects and reduced oxidative stress and ER stress.	Hydrogen Sulfide	90-93	cystathionine beta-synthase	Mus musculus	86-89
28751019-0	2017	The cystathionine beta-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia.	Hydrogen Sulfide	32-48	cystathionine beta-synthase	Mus musculus	4-31
28751019-5	2017	Expression of the H2S synthase cystathionine beta-synthase (CBS) and H2S synthetic activity were rapidly decreased in the ischemic brain tissue following MCAO.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	31-58
28751019-5	2017	Expression of the H2S synthase cystathionine beta-synthase (CBS) and H2S synthetic activity were rapidly decreased in the ischemic brain tissue following MCAO.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	60-63
28751019-6	2017	Consistently, when cultured microglia were polarized toward a pro-inflammatory phenotype with conditioned medium collected from neurons that had been subjected to oxygen-glucose deprivation (OGD neuron CM), they displayed reduced CBS expression and H2S production.	oxygen-glucose	163-177	cystathionine beta-synthase	Mus musculus	230-233
28751019-7	2017	Enhancing H2S bioavailability either by overexpressing CBS or by supplementing with exogenous H2S donors promoted a shift in microglial polarization from ischemia-induced pro-inflammatory phenotypes toward anti-inflammatory phenotypes.	Hydrogen Sulfide	10-13	cystathionine beta-synthase	Mus musculus	55-58
28751019-10	2017	Our results suggested that reduced CBS-H2S-AMPK cascade activity contributed to microglia-mediated neuroinflammation following stroke.	Hydrogen Sulfide	39-42	cystathionine beta-synthase	Mus musculus	35-38
28751019-11	2017	Targeting the CBS-H2S pathway is a promising therapeutic approach for ischemic stroke.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	14-17
28735240-3	2017	L-Cysteine is catalyzed by cystathionine-beta-synthase (CBS) in the brain and sequentially produces endogenous H2S.	Cysteine	0-10	cystathionine beta-synthase	Mus musculus	27-54
28735240-3	2017	L-Cysteine is catalyzed by cystathionine-beta-synthase (CBS) in the brain and sequentially produces endogenous H2S.	Cysteine	0-10	cystathionine beta-synthase	Mus musculus	56-59
28735240-3	2017	L-Cysteine is catalyzed by cystathionine-beta-synthase (CBS) in the brain and sequentially produces endogenous H2S.	Hydrogen Sulfide	111-114	cystathionine beta-synthase	Mus musculus	56-59
28488385-1	2017	Mutations in the cystathionine beta-synthase (CBS) gene are the cause of classical homocystinuria, the most common inborn error in sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Mus musculus	46-49
28488385-5	2017	On a C3H/HeJ background, zinc-induced Tg-R266K Cbs-/- mice express CBS mRNA, but have very low levels of CBS protein and enzyme activity, resulting in extreme elevations in serum total homocysteine (tHcy).	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
28488385-5	2017	On a C3H/HeJ background, zinc-induced Tg-R266K Cbs-/- mice express CBS mRNA, but have very low levels of CBS protein and enzyme activity, resulting in extreme elevations in serum total homocysteine (tHcy).	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	67-70
28623294-0	2017	H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	60-87
28623294-0	2017	H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes.	Homocysteine	8-20	cystathionine beta-synthase	Mus musculus	60-87
28623294-7	2017	Conversely, in the homocysteine-treated cardiomyocytes, CBS and miR-133a were downregulated and hypertrophy was induced.	Homocysteine	19-31	cystathionine beta-synthase	Mus musculus	56-59
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	94-121
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	123-126
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	94-121
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	123-126
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Homocysteine	78-90	cystathionine beta-synthase	Mus musculus	94-121
28623294-1	2017	Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.	Homocysteine	78-90	cystathionine beta-synthase	Mus musculus	123-126
28623294-3	2017	We hypothesize that homocysteine and H2S regulate CBS and CSE expressions in a dose dependent manner in cardiomyocytes, and CBS deficiency induces cardiac CSE expression.	Homocysteine	20-32	cystathionine beta-synthase	Mus musculus	50-53
28623294-3	2017	We hypothesize that homocysteine and H2S regulate CBS and CSE expressions in a dose dependent manner in cardiomyocytes, and CBS deficiency induces cardiac CSE expression.	Hydrogen Sulfide	37-40	cystathionine beta-synthase	Mus musculus	50-53
28623294-5	2017	We found that homocysteine upregulates CSE but downregulates CBS whereas Na2S/GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner.	Homocysteine	14-26	cystathionine beta-synthase	Mus musculus	61-64
28623294-5	2017	We found that homocysteine upregulates CSE but downregulates CBS whereas Na2S/GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner.	sodium sulfide	73-77	cystathionine beta-synthase	Mus musculus	120-123
28623294-5	2017	We found that homocysteine upregulates CSE but downregulates CBS whereas Na2S/GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner.	GYY 4137	78-85	cystathionine beta-synthase	Mus musculus	120-123
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Cysteine	107-112	cystathionine beta-synthase	Mus musculus	117-144
28232079-9	2017	Under oxidizing conditions, an increase in cystathionine beta-synthase activity might indirectly result in an increase in the antioxidant glutathione level; this was reflected by the increased GSH/GSSG ratio in the liver, but not in the brain, where a trace activity of gamma-cystathionase is normally detected.	Glutathione	138-149	cystathionine beta-synthase	Mus musculus	43-70
28232079-9	2017	Under oxidizing conditions, an increase in cystathionine beta-synthase activity might indirectly result in an increase in the antioxidant glutathione level; this was reflected by the increased GSH/GSSG ratio in the liver, but not in the brain, where a trace activity of gamma-cystathionase is normally detected.	Glutathione	193-196	cystathionine beta-synthase	Mus musculus	43-70
28232079-9	2017	Under oxidizing conditions, an increase in cystathionine beta-synthase activity might indirectly result in an increase in the antioxidant glutathione level; this was reflected by the increased GSH/GSSG ratio in the liver, but not in the brain, where a trace activity of gamma-cystathionase is normally detected.	Glutathione Disulfide	197-201	cystathionine beta-synthase	Mus musculus	43-70
28384716-8	2017	Interestingly, levels of H2S were markedly increased in retinas of Mthfr+/- and Cbs+/- mice compared with WT.	Hydrogen Sulfide	25-28	cystathionine beta-synthase	Mus musculus	80-83
28091526-4	2017	Our bioinformatic analysis revealed absence of key enzymes in the biosynthesis of cysteine namely cystathionine-beta-synthase and cystathionine-gamma-lyase in the parasite.	Cysteine	82-90	cystathionine beta-synthase	Mus musculus	98-125
27293214-10	2016	Using these assays with as little as 2-20 muL of urine I show that MUP carry N-linked and S-linked Hcy and that N-Hcy-MUP and S-Hcy-MUP and Hcy-thiolactone are severely elevated in cystathionine beta-synthase-deficient mice.	homocysteine thiolactone	140-155	cystathionine beta-synthase	Mus musculus	181-208
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	117-144
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	146-149
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Cysteine	95-105	cystathionine beta-synthase	Mus musculus	117-144
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Cysteine	95-105	cystathionine beta-synthase	Mus musculus	146-149
27326921-2	2016	H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Cysteine	107-112	cystathionine beta-synthase	Mus musculus	146-149
27326921-5	2016	We firstly demonstrated that both enzymes, CBS and CSE were expressed, and able to convert l-Cys into H2S in mouse uterus.	Cysteine	91-96	cystathionine beta-synthase	Mus musculus	43-46
27326921-5	2016	We firstly demonstrated that both enzymes, CBS and CSE were expressed, and able to convert l-Cys into H2S in mouse uterus.	Hydrogen Sulfide	102-105	cystathionine beta-synthase	Mus musculus	43-46
27326921-6	2016	Thereafter, sildenafil significantly increased H2S production in mouse uterus and this effect was abrogated by CBS or CSE inhibition.	Sildenafil Citrate	12-22	cystathionine beta-synthase	Mus musculus	111-114
27273718-2	2016	Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	49-76
27273718-2	2016	Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	78-81
27273718-2	2016	Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	35-45	cystathionine beta-synthase	Mus musculus	49-76
27273718-2	2016	Hydrogen sulfide is generated from L-cysteine by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	35-45	cystathionine beta-synthase	Mus musculus	78-81
26599618-0	2016	The effect of dietary modulation of sulfur amino acids on cystathionine beta synthase-deficient mice.	Amino Acids, Sulfur	36-54	cystathionine beta-synthase	Mus musculus	58-85
26961888-0	2016	Endogenous CBS-H2S Pathway Contributes to the Development of CCI-Induced Neuropathic Pain.	Hydrogen Sulfide	15-18	cystathionine beta-synthase	Mus musculus	11-14
26961888-2	2016	In this study, the relationship between endogenous CBS-H2S pathway in L4-6 spinal cord and neuropathic pain was explored.	Hydrogen Sulfide	55-58	cystathionine beta-synthase	Mus musculus	51-54
26961888-8	2016	Correlation analysis showed pain thresholds had negative relationships with protein expression of CBS and H2S formation.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Mus musculus	98-101
26961888-9	2016	Treatment with AOAA, a CBS inhibitor, inhibited CCI-induced upregulation of CBS expression and H2S formation (P < 0.05).	CCI	48-51	cystathionine beta-synthase	Mus musculus	23-26
26961888-9	2016	Treatment with AOAA, a CBS inhibitor, inhibited CCI-induced upregulation of CBS expression and H2S formation (P < 0.05).	CCI	48-51	cystathionine beta-synthase	Mus musculus	76-79
26961888-9	2016	Treatment with AOAA, a CBS inhibitor, inhibited CCI-induced upregulation of CBS expression and H2S formation (P < 0.05).	Hydrogen Sulfide	95-98	cystathionine beta-synthase	Mus musculus	23-26
26961888-11	2016	This indicated that CBS-H2S pathway promoted the development of neuropathic pain.	Hydrogen Sulfide	24-27	cystathionine beta-synthase	Mus musculus	20-23
26961888-12	2016	CBS-H2S pathway could be a promising target for treatment of neuropathic pain.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Mus musculus	0-3
26019015-6	2016	Hcy treatment also decreases the expression of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) in the brain along with increased expression of NMDA-R (NR1) and synaptosomal Ca(2+) indicating excitotoxicity.	Homocysteine	0-3	cystathionine beta-synthase	Mus musculus	47-74
26019015-6	2016	Hcy treatment also decreases the expression of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) in the brain along with increased expression of NMDA-R (NR1) and synaptosomal Ca(2+) indicating excitotoxicity.	Homocysteine	0-3	cystathionine beta-synthase	Mus musculus	76-79
26885895-4	2016	Initial studies in a mouse model of HHcy, in which cystathionine-beta-synthase (cbs) was deficient, revealed abnormal RPE cell morphology with features similar to that of AMD upon optical coherence tomography (OCT), fluorescein angiography (FA), histological, and electron microscopic examinations.	Fluorescein	216-227	cystathionine beta-synthase	Mus musculus	51-78
27183384-4	2016	A PEGylated form of CBS provided long-term stability and, when used in conjunction with the methylation agent betaine, dramatically increased survival in mice fed a normal diet.	Betaine	110-117	cystathionine beta-synthase	Mus musculus	20-23
27183385-2	2016	CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.	Homocysteine	14-26	cystathionine beta-synthase	Mus musculus	0-3
27183385-2	2016	CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.	Serine	31-37	cystathionine beta-synthase	Mus musculus	0-3
27183385-2	2016	CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.	Cystathionine	41-54	cystathionine beta-synthase	Mus musculus	0-3
27183385-2	2016	CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.	Cysteine	18-26	cystathionine beta-synthase	Mus musculus	0-3
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	Amino Acids, Sulfur	158-176	cystathionine beta-synthase	Mus musculus	53-56
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	Homocysteine	239-251	cystathionine beta-synthase	Mus musculus	53-56
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	thcy	253-257	cystathionine beta-synthase	Mus musculus	53-56
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	Cysteine	243-251	cystathionine beta-synthase	Mus musculus	53-56
27183385-6	2016	Moreover, the decrease in homocysteine and the normalization of cysteine in PEGylated CBS-treated model mice were accompanied by improvement of histopathological liver symptoms and increased survival.	Homocysteine	26-38	cystathionine beta-synthase	Mus musculus	86-89
27183385-6	2016	Moreover, the decrease in homocysteine and the normalization of cysteine in PEGylated CBS-treated model mice were accompanied by improvement of histopathological liver symptoms and increased survival.	Cysteine	30-38	cystathionine beta-synthase	Mus musculus	86-89
26743682-6	2016	More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S.	Hydrogen Sulfide	62-65	cystathionine beta-synthase	Mus musculus	100-127
26743682-6	2016	More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S.	Hydrogen Sulfide	62-65	cystathionine beta-synthase	Mus musculus	129-132
26743682-6	2016	More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S.	Hydrogen Sulfide	191-194	cystathionine beta-synthase	Mus musculus	100-127
26743682-6	2016	More importantly, it realized the visualization of endogenous H2S generated in cells overexpressing cystathionine beta-synthase (CBS), one of the enzymes responsible for producing endogenous H2S.	Hydrogen Sulfide	191-194	cystathionine beta-synthase	Mus musculus	129-132
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Methionine	57-67	cystathionine beta-synthase	Mus musculus	0-27
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Cysteine	72-80	cystathionine beta-synthase	Mus musculus	0-27
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Sulfur	163-169	cystathionine beta-synthase	Mus musculus	0-27
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Methionine	175-185	cystathionine beta-synthase	Mus musculus	0-27
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Cysteine	189-197	cystathionine beta-synthase	Mus musculus	0-27
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	Homocysteine	106-118	cystathionine beta-synthase	Mus musculus	17-20
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	thcy	120-124	cystathionine beta-synthase	Mus musculus	17-20
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	Methionine	130-140	cystathionine beta-synthase	Mus musculus	17-20
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	Cysteine	110-118	cystathionine beta-synthase	Mus musculus	17-20
26599618-5	2016	Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine.	thcy	91-95	cystathionine beta-synthase	Mus musculus	9-12
26599618-5	2016	Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine.	Methionine	122-132	cystathionine beta-synthase	Mus musculus	9-12
26599618-5	2016	Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine.	Cysteine	149-157	cystathionine beta-synthase	Mus musculus	9-12
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Homocysteine	5-17	cystathionine beta-synthase	Mus musculus	111-138
27882191-5	2016	The expression of two known H2S-producing enzymes in kidney, cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), decreased significantly during ageing.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Mus musculus	97-124
27882191-5	2016	The expression of two known H2S-producing enzymes in kidney, cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), decreased significantly during ageing.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Mus musculus	126-129
26531221-1	2015	H2S is produced mainly by two enzymes:cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), using L-cysteine (L-Cys) as the substrate.	Cysteine	115-125	cystathionine beta-synthase	Mus musculus	38-65
26531221-1	2015	H2S is produced mainly by two enzymes:cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), using L-cysteine (L-Cys) as the substrate.	Cysteine	127-132	cystathionine beta-synthase	Mus musculus	38-65
26232299-0	2015	The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Mus musculus	27-54
26232299-4	2015	H2S is endogenously generated by cystathionine beta-synthase (Cbs) and cystathionine gamma-lyase (Cth).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	33-60
26232299-4	2015	H2S is endogenously generated by cystathionine beta-synthase (Cbs) and cystathionine gamma-lyase (Cth).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	62-65
26232299-10	2015	These data confirm a key role for the H2S-generating enzymes Cbs and Cth in pulmonary vascular development and homeostasis and in lung alveolarization.	Hydrogen Sulfide	38-41	cystathionine beta-synthase	Mus musculus	61-64
26304691-1	2015	While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known.	Glutathione	123-126	cystathionine beta-synthase	Mus musculus	281-308
26231230-1	2016	Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy).	Homocysteine	125-137	cystathionine beta-synthase	Mus musculus	0-27
26231230-1	2016	Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy).	thcy	139-143	cystathionine beta-synthase	Mus musculus	0-27
26231230-4	2016	Here, we have examined the effect of a betaine supplemented diet on the Tg-I278T Cbs (-/-) mouse model of CBS deficiency and compared its effectiveness to our previously published data using a methionine restricted diet.	Betaine	39-46	cystathionine beta-synthase	Mus musculus	81-84
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	Betaine	27-34	cystathionine beta-synthase	Mus musculus	9-12
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	thcy	116-120	cystathionine beta-synthase	Mus musculus	9-12
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	Methionine	157-167	cystathionine beta-synthase	Mus musculus	9-12
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	25-28
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Thioguanine	16-18	cystathionine beta-synthase	Mus musculus	25-28
26231230-7	2016	Betaine supplementation largely reversed the hair loss phenotype in Tg-I278T Cbs (-/-) animals, but was far less effective than methionine restriction in reversing the weight-loss, fat-loss, and osteoporosis phenotypes.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	77-80
26231230-8	2016	Surprisingly, betaine supplementation had several negative effects in control Tg-I278T Cbs (+/-) mice including decreased weight gain, lean mass, and bone mineral density.	Betaine	14-21	cystathionine beta-synthase	Mus musculus	87-90
26231230-8	2016	Surprisingly, betaine supplementation had several negative effects in control Tg-I278T Cbs (+/-) mice including decreased weight gain, lean mass, and bone mineral density.	Thioguanine	78-80	cystathionine beta-synthase	Mus musculus	87-90
27883916-7	2016	injection of NaHS improved learning memory deficits, decreased the number of senile plaques, Abeta1-40 and Abeta1-42 levels, suppressed neurons loss, together with up-regulated the levels of cystathionine-beta-synthase (CBS) and 3-mercaptopyruvate-sulfurtransferase (3MST).	sodium bisulfide	13-17	cystathionine beta-synthase	Mus musculus	191-218
27883916-7	2016	injection of NaHS improved learning memory deficits, decreased the number of senile plaques, Abeta1-40 and Abeta1-42 levels, suppressed neurons loss, together with up-regulated the levels of cystathionine-beta-synthase (CBS) and 3-mercaptopyruvate-sulfurtransferase (3MST).	sodium bisulfide	13-17	cystathionine beta-synthase	Mus musculus	220-223
26304691-1	2015	While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known.	N-acetyl-4-benzoquinoneimine	6-34	cystathionine beta-synthase	Mus musculus	281-308
26304691-1	2015	While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known.	N-acetyl-4-benzoquinoneimine	36-41	cystathionine beta-synthase	Mus musculus	281-308
26304691-1	2015	While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known.	Acetaminophen	75-88	cystathionine beta-synthase	Mus musculus	281-308
26304691-1	2015	While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known.	4-amino-N-acetyl-N-methylaniline	90-94	cystathionine beta-synthase	Mus musculus	281-308
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Homocysteine	5-17	cystathionine beta-synthase	Mus musculus	140-143
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionine beta-synthase	Mus musculus	111-138
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionine beta-synthase	Mus musculus	140-143
25740079-13	2015	NaHS effects are absent in Cth (-/-), Cbs (-/-), and dietary hyperhomocysteinemic mice.	sodium bisulfide	0-4	cystathionine beta-synthase	Mus musculus	38-41
25772816-9	2015	Addition of homocysteine or methionine resulted in higher intracellular concentrations of homocysteine, which is a cosubstrate for cystathionine beta-synthase (CBS).	Homocysteine	12-24	cystathionine beta-synthase	Mus musculus	131-158
25772816-9	2015	Addition of homocysteine or methionine resulted in higher intracellular concentrations of homocysteine, which is a cosubstrate for cystathionine beta-synthase (CBS).	Methionine	28-38	cystathionine beta-synthase	Mus musculus	131-158
25772816-9	2015	Addition of homocysteine or methionine resulted in higher intracellular concentrations of homocysteine, which is a cosubstrate for cystathionine beta-synthase (CBS).	Homocysteine	90-102	cystathionine beta-synthase	Mus musculus	131-158
25659756-3	2015	We concluded that this was due to decreased H2S production by downregulation of CBS and CSE enzymes.	Hydrogen Sulfide	44-47	cystathionine beta-synthase	Mus musculus	80-83
25307719-6	2015	The method presented here allows for evaluating the relative contribution of CBS and CTH to generation of H2S in tissues.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Mus musculus	77-80
25659756-8	2015	Dysregulated expression of MMP-9, CBS, CSE, NMDA-R1 and Cxs-40, -43 was also normalized in Akita mice treated with H2S.	Hydrogen Sulfide	115-118	cystathionine beta-synthase	Mus musculus	34-37
25644346-13	2015	Silencing betaine homocysteine methyltransferase, cystathionine beta-synthase, or methionine increased intracellular homocysteine and TG concentrations by >2-fold, which was reversed by L-serine when L-serine-independent betaine homocysteine methyltransferase was knocked down.	Triglycerides	134-136	cystathionine beta-synthase	Mus musculus	50-77
25945238-1	2015	OBJECTIVES: This study was undertaken to investigate the protective effects of vitamin B6, cofactor for cystathionine-gamma lyase and cystathionine-beta synthase (producers of H2S), alone and in combination with L-cysteine, H2S precursor, on indomethacin-, and ethanol-induced gastric lesions in male NMRI mice.	Hydrogen Sulfide	176-179	cystathionine beta-synthase	Mus musculus	134-161
25644346-13	2015	Silencing betaine homocysteine methyltransferase, cystathionine beta-synthase, or methionine increased intracellular homocysteine and TG concentrations by >2-fold, which was reversed by L-serine when L-serine-independent betaine homocysteine methyltransferase was knocked down.	Serine	189-197	cystathionine beta-synthase	Mus musculus	50-77
25644346-13	2015	Silencing betaine homocysteine methyltransferase, cystathionine beta-synthase, or methionine increased intracellular homocysteine and TG concentrations by >2-fold, which was reversed by L-serine when L-serine-independent betaine homocysteine methyltransferase was knocked down.	Serine	203-211	cystathionine beta-synthase	Mus musculus	50-77
25008073-0	2014	Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine beta-synthase, and K+ channels.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	123-150
24702258-9	2014	Local suppression of CBS or CSE in adrenal glands significantly increased the mortality in endotoxemic mice, which was also improved by GYY4137.	GYY 4137	136-143	cystathionine beta-synthase	Mus musculus	21-24
26078817-6	2015	The expression of the H2S-generating enzymes, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-beta-synthase levels were significantly increased.	Hydrogen Sulfide	22-25	cystathionine beta-synthase	Mus musculus	186-213
26078817-6	2015	The expression of the H2S-generating enzymes, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-beta-synthase levels were significantly increased.	Fructose	159-167	cystathionine beta-synthase	Mus musculus	186-213
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	77-93	cystathionine beta-synthase	Mus musculus	115-142
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	77-93	cystathionine beta-synthase	Mus musculus	144-147
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	95-98	cystathionine beta-synthase	Mus musculus	115-142
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	95-98	cystathionine beta-synthase	Mus musculus	144-147
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	89-101	cystathionine beta-synthase	Mus musculus	42-69
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	89-101	cystathionine beta-synthase	Mus musculus	71-74
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	1-4	cystathionine beta-synthase	Mus musculus	42-69
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	1-4	cystathionine beta-synthase	Mus musculus	71-74
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	tg-hcbs	165-172	cystathionine beta-synthase	Mus musculus	42-69
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	tg-hcbs	165-172	cystathionine beta-synthase	Mus musculus	71-74
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Zinc	180-182	cystathionine beta-synthase	Mus musculus	42-69
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Zinc	180-182	cystathionine beta-synthase	Mus musculus	71-74
25008073-4	2014	ES-induced contractions were neurotoxin-sensitive and increased by aminooxyacetic acid, an inhibitor of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase, but not by D,L-propargylglycine, a selective inhibitor of cystathionine gamma-lyase, in an ES trial-dependent manner.	Aminooxyacetic Acid	67-86	cystathionine beta-synthase	Mus musculus	104-131
24891521-0	2014	Altered hepatic sulfur metabolism in cystathionine beta-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.	Sulfur	16-22	cystathionine beta-synthase	Mus musculus	37-64
25086357-0	2014	Downregulation of cystathionine beta-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.	Rotenone	78-86	cystathionine beta-synthase	Mus musculus	18-45
25086357-6	2014	Moreover, the transcription and protein expression of cystathionine-beta-synthase (CBS), as well as hydrogen sulfide (H2S) production were decreased in rotenone-treated primary microglia.	Rotenone	152-160	cystathionine beta-synthase	Mus musculus	54-81
25086357-6	2014	Moreover, the transcription and protein expression of cystathionine-beta-synthase (CBS), as well as hydrogen sulfide (H2S) production were decreased in rotenone-treated primary microglia.	Rotenone	152-160	cystathionine beta-synthase	Mus musculus	83-86
25086357-7	2014	Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 production in response to rotenone stimulation as compared to vector-transfected cells.	Hydrogen Sulfide	21-24	cystathionine beta-synthase	Mus musculus	29-32
25086357-7	2014	Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 production in response to rotenone stimulation as compared to vector-transfected cells.	Rotenone	219-227	cystathionine beta-synthase	Mus musculus	29-32
25086357-9	2014	In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia.	Reactive Oxygen Species	25-48	cystathionine beta-synthase	Mus musculus	117-120
25086357-9	2014	In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia.	Reactive Oxygen Species	50-53	cystathionine beta-synthase	Mus musculus	117-120
25086357-9	2014	In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia.	Acetylcysteine	65-84	cystathionine beta-synthase	Mus musculus	117-120
25086357-9	2014	In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia.	Rotenone	150-158	cystathionine beta-synthase	Mus musculus	117-120
25086357-11	2014	Taken together, these results reveal that probably via triggering ROS formation, rotenone suppressed the CBS-H2S pathway and thus promoted microglia polarization toward M1 pro-inflammatory phenotype.	Reactive Oxygen Species	66-69	cystathionine beta-synthase	Mus musculus	105-108
25086357-11	2014	Taken together, these results reveal that probably via triggering ROS formation, rotenone suppressed the CBS-H2S pathway and thus promoted microglia polarization toward M1 pro-inflammatory phenotype.	Rotenone	81-89	cystathionine beta-synthase	Mus musculus	105-108
25086357-11	2014	Taken together, these results reveal that probably via triggering ROS formation, rotenone suppressed the CBS-H2S pathway and thus promoted microglia polarization toward M1 pro-inflammatory phenotype.	Hydrogen Sulfide	109-112	cystathionine beta-synthase	Mus musculus	105-108
24730561-0	2014	Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.	Ethanol	45-52	cystathionine beta-synthase	Mus musculus	96-123
24874797-6	2014	A significant reduction in sulphide levels and CBS mRNA expression was observed in the hippocampus of mouse models of lipopolysaccharide-induced neuroinflammation-related diseases, suggesting that decreased levels of endogenous H2S might be involved in the pathogenesis of neuroinflammation-related neurodegenerative diseases.	Hydrogen Sulfide	228-231	cystathionine beta-synthase	Mus musculus	47-50
24730561-0	2014	Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.	Betaine	65-72	cystathionine beta-synthase	Mus musculus	96-123
24491430-1	2014	Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain.	Hydrogen Sulfide	79-95	cystathionine beta-synthase	Mus musculus	0-27
24491430-1	2014	Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain.	Hydrogen Sulfide	79-95	cystathionine beta-synthase	Mus musculus	29-32
24491430-1	2014	Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Mus musculus	0-27
24491430-1	2014	Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Mus musculus	29-32
24491430-5	2014	We hypothesize that CBS/H2S pathway plays an important role in the protection of learning and memory functions in the brain at the level of the hippocampus.	Hydrogen Sulfide	24-27	cystathionine beta-synthase	Mus musculus	20-23
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Serine	64-70	cystathionine beta-synthase	Mus musculus	0-27
24189943-0	2014	Cystathionine beta-synthase-deficient mice thrive on a low-methionine diet.	Methionine	59-69	cystathionine beta-synthase	Mus musculus	0-27
24189943-4	2014	Cbs(-/-) mice fed the MRD had a 77% decrease in tHcy, 28% increase in weight, 130% increase in fat mass, 82% increase in Scd-1 expression, and 10.6% increase in bone density and entirely lacked the alopecia phenotype observed in age-matched Cbs(-/-) mice fed the RD.	thcy	48-52	cystathionine beta-synthase	Mus musculus	0-3
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	35-62
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	64-67
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	35-62
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	64-67
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Homocysteine	140-152	cystathionine beta-synthase	Mus musculus	35-62
23846016-1	2013	Hydrogen sulfide (H2S) produced by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles.	Homocysteine	140-152	cystathionine beta-synthase	Mus musculus	64-67
23846016-7	2013	In addition, NaHS mitigated decreases of CBS and CSE expressions, and H2S concentration in the kidney.	sodium bisulfide	13-17	cystathionine beta-synthase	Mus musculus	41-44
24117258-1	2013	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) catalyze homocysteine (Hcy) metabolism via the trans-sulfuration pathway.	Homocysteine	93-96	cystathionine beta-synthase	Mus musculus	0-27
23350603-4	2013	Accumulation of cystathionine and lanthionine appeared to result from cystathionine beta-synthase (CBS)-mediated cysteine desulfhydration.	Cystathionine	16-29	cystathionine beta-synthase	Mus musculus	70-97
23350603-4	2013	Accumulation of cystathionine and lanthionine appeared to result from cystathionine beta-synthase (CBS)-mediated cysteine desulfhydration.	lanthionine	34-45	cystathionine beta-synthase	Mus musculus	70-97
23350603-4	2013	Accumulation of cystathionine and lanthionine appeared to result from cystathionine beta-synthase (CBS)-mediated cysteine desulfhydration.	Cysteine	113-121	cystathionine beta-synthase	Mus musculus	70-97
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Methionine	166-176	cystathionine beta-synthase	Mus musculus	0-27
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Methionine	166-176	cystathionine beta-synthase	Mus musculus	29-32
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cysteine	80-88	cystathionine beta-synthase	Mus musculus	0-27
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cysteine	80-88	cystathionine beta-synthase	Mus musculus	29-32
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Serine	64-70	cystathionine beta-synthase	Mus musculus	29-32
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Homocysteine	76-88	cystathionine beta-synthase	Mus musculus	0-27
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Homocysteine	76-88	cystathionine beta-synthase	Mus musculus	29-32
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cystathionine	97-110	cystathionine beta-synthase	Mus musculus	0-27
23315129-1	2013	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cystathionine	97-110	cystathionine beta-synthase	Mus musculus	29-32
23612188-1	2013	In this study, a boron-dipyrromethene (BODIPY)-based fluorescent chemosensor CBS was developed for metal ion sensing.	Boron dipyrromethene	17-37	cystathionine beta-synthase	Mus musculus	77-80
23592311-1	2013	Cystathionine beta-synthase (CBS) deficiency is an inborn error of metabolism characterized by extremely elevated levels of plasma total homocysteine.	Homocysteine	137-149	cystathionine beta-synthase	Mus musculus	0-27
23612188-8	2013	Confocal fluorescence microscopy imaging using RAW264.7 cells showed that CBS could be used as an effective fluorescent probe for detecting Cu(2+) in living cells.	cupric ion	140-146	cystathionine beta-synthase	Mus musculus	74-77
23807810-8	2013	Cystathionine beta-synthase was induced, but cysteine dioxygenase was downregulated, both of which would contribute to the elevation of cysteine and its product, glutathione, in liver.	Glutathione	162-173	cystathionine beta-synthase	Mus musculus	0-27
23632630-6	2013	H2S-synthesizing enzymes cystathionine-beta-synthase and cystathionine-gamma-lyase were also diminished.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Mus musculus	25-52
22657153-7	2013	I/R reduced the expression and activities of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), both of which are H(2)S-producing enzymes, in the kidneys.	Hydrogen Sulfide	134-139	cystathionine beta-synthase	Mus musculus	45-72
23612188-1	2013	In this study, a boron-dipyrromethene (BODIPY)-based fluorescent chemosensor CBS was developed for metal ion sensing.	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	39-45	cystathionine beta-synthase	Mus musculus	77-80
23612188-1	2013	In this study, a boron-dipyrromethene (BODIPY)-based fluorescent chemosensor CBS was developed for metal ion sensing.	Metals	99-104	cystathionine beta-synthase	Mus musculus	77-80
23612188-2	2013	It was found that CBS containing an NSe2 moiety exhibited high selectivity for Cu(2+) detection while CBS in the presence of Cu(2+) displayed significant fluorescence enhancement.	cupric ion	79-85	cystathionine beta-synthase	Mus musculus	18-21
23612188-2	2013	It was found that CBS containing an NSe2 moiety exhibited high selectivity for Cu(2+) detection while CBS in the presence of Cu(2+) displayed significant fluorescence enhancement.	cupric ion	125-131	cystathionine beta-synthase	Mus musculus	18-21
23612188-2	2013	It was found that CBS containing an NSe2 moiety exhibited high selectivity for Cu(2+) detection while CBS in the presence of Cu(2+) displayed significant fluorescence enhancement.	cupric ion	125-131	cystathionine beta-synthase	Mus musculus	102-105
23612188-4	2013	The binding constant (Ka) of Cu(2+) binding to CBS was found to be 7.28 x 10(3) M(-1).	cupric ion	29-35	cystathionine beta-synthase	Mus musculus	47-50
23612188-5	2013	The binding ratio of CBS-Cu(2+) complexes was determined from the Job plot to be 1 : 1.	cupric ion	25-31	cystathionine beta-synthase	Mus musculus	21-24
23612188-6	2013	The maximum fluorescence enhancement caused by Cu(2+) binding to CBS was observed over the pH range 5.0-9.0.	cupric ion	47-53	cystathionine beta-synthase	Mus musculus	65-68
23612188-7	2013	Additionally, the methyl thiazolyl tetrazolium (MTT) assay demonstrated the CBS to have low cytotoxicity.	methyl thiazolyl tetrazolium	18-46	cystathionine beta-synthase	Mus musculus	76-79
23612188-7	2013	Additionally, the methyl thiazolyl tetrazolium (MTT) assay demonstrated the CBS to have low cytotoxicity.	monooxyethylene trimethylolpropane tristearate	48-51	cystathionine beta-synthase	Mus musculus	76-79
23429073-7	2013	We recently showed that hepatic expression of DYRK1A, a serine/threonine kinase, is negatively correlated with plasma homocysteine levels in cystathionine-beta-synthase deficient mice, a mouse model of hyperhomocysteinemia.	Homocysteine	118-130	cystathionine beta-synthase	Mus musculus	141-168
23429073-10	2013	The elevation of pyridoxal phosphate was consistent with the increase in cystathionine-beta-synthase activity.	Pyridoxal Phosphate	17-36	cystathionine beta-synthase	Mus musculus	73-100
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Homocysteine	130-142	cystathionine beta-synthase	Mus musculus	30-57
23439872-4	2013	Strain-dependent down-regulation of several key one-carbon metabolism genes, including methionine adenosyltransferase 1alpha (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofolate reductase (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrofolate dehydrogenase 1 (Mthfd1), was observed.	Carbon	52-58	cystathionine beta-synthase	Mus musculus	163-166
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Homocysteine	130-142	cystathionine beta-synthase	Mus musculus	59-62
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Cystathionine	146-159	cystathionine beta-synthase	Mus musculus	30-57
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Cystathionine	146-159	cystathionine beta-synthase	Mus musculus	59-62
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Cysteine	134-142	cystathionine beta-synthase	Mus musculus	30-57
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Cysteine	134-142	cystathionine beta-synthase	Mus musculus	59-62
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Glutathione	248-259	cystathionine beta-synthase	Mus musculus	30-57
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Glutathione	248-259	cystathionine beta-synthase	Mus musculus	59-62
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Glutathione	261-264	cystathionine beta-synthase	Mus musculus	30-57
23470016-1	2013	UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH).	Glutathione	261-264	cystathionine beta-synthase	Mus musculus	59-62
23470016-12	2013	CBS activity was detected in Muller cells by fluorescent detection of H2S.	Hydrogen Sulfide	70-73	cystathionine beta-synthase	Mus musculus	0-3
23470016-15	2013	These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina.	Glutathione	114-117	cystathionine beta-synthase	Mus musculus	56-59
23903628-0	2013	Immunohistochemical approach reveals localization of cystathionine-gamma-lyase and cystathionine-beta-synthetase in ethanol-induced gastric mucosa damage in mice.	Ethanol	116-123	cystathionine beta-synthase	Mus musculus	83-112
23903628-6	2013	RESULTS: We have demonstrated a non-specific expression of CBS in the normal gastric mucosa and expression of CSE occurring mainly in the parietal cells of the animals treated with ethanol.	Ethanol	181-188	cystathionine beta-synthase	Mus musculus	59-62
23903628-7	2013	CONCLUSION: Thus, we demonstrated that the expression of CBS appears to be constitutive and diffuse across the gastric epithelium, while the expression of CSE appears to be induced in parietal cells by damage agents such as ethanol.	Ethanol	224-231	cystathionine beta-synthase	Mus musculus	57-60
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Cystathionine	12-25	cystathionine beta-synthase	Mus musculus	167-194
23325453-4	2013	Expression of Cystathionine-beta-synthase (CBS) mRNA as H2S-producing enzymes in mouse brain was determined by reverse transcriptase-polymerase chain reaction (RT-PCR).	Hydrogen Sulfide	56-59	cystathionine beta-synthase	Mus musculus	14-41
23325453-4	2013	Expression of Cystathionine-beta-synthase (CBS) mRNA as H2S-producing enzymes in mouse brain was determined by reverse transcriptase-polymerase chain reaction (RT-PCR).	Hydrogen Sulfide	56-59	cystathionine beta-synthase	Mus musculus	43-46
23325453-8	2013	Hydrogen sulfide in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	110-113
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Cystathionine	12-25	cystathionine beta-synthase	Mus musculus	196-199
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Serine	110-116	cystathionine beta-synthase	Mus musculus	167-194
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	121-133	cystathionine beta-synthase	Mus musculus	167-194
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	121-133	cystathionine beta-synthase	Mus musculus	196-199
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	135-138	cystathionine beta-synthase	Mus musculus	167-194
22854956-2	2012	In mammals, cystathionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine and homocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	135-138	cystathionine beta-synthase	Mus musculus	196-199
22158625-10	2012	Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyase, hydrogen sulfide-generating enzymes, was significantly reduced in mice with type 1 diabetes or type 2 diabetes, coinciding with renal hypertrophy and matrix accumulation.	Hydrogen Sulfide	85-101	cystathionine beta-synthase	Mus musculus	26-53
22215680-3	2012	Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular redox status by modulating glutathione (GSH) levels.	Glutathione	174-185	cystathionine beta-synthase	Mus musculus	36-63
22215680-3	2012	Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular redox status by modulating glutathione (GSH) levels.	Glutathione	187-190	cystathionine beta-synthase	Mus musculus	36-63
22192524-0	2012	Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.	Betaine	10-17	cystathionine beta-synthase	Mus musculus	47-74
22314625-2	2012	The enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) had long been speculated to generate H2S, and inhibitors of these enzymes had been employed to characterize influences of H2S in various organs.	Hydrogen Sulfide	119-122	cystathionine beta-synthase	Mus musculus	48-75
22314625-2	2012	The enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) had long been speculated to generate H2S, and inhibitors of these enzymes had been employed to characterize influences of H2S in various organs.	Hydrogen Sulfide	204-207	cystathionine beta-synthase	Mus musculus	48-75
22396778-1	2012	Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	146-173
23080150-4	2012	The purpose of this article is to review recent studies addressing the role of H2S in carotid body.Cystathionine gamma-lyase (CSE) and cystathionine beta synthase (CBS) are the two major enzymes that catalyze the formation of endogenous H2S.	Hydrogen Sulfide	79-82	cystathionine beta-synthase	Mus musculus	135-162
23080150-4	2012	The purpose of this article is to review recent studies addressing the role of H2S in carotid body.Cystathionine gamma-lyase (CSE) and cystathionine beta synthase (CBS) are the two major enzymes that catalyze the formation of endogenous H2S.	Hydrogen Sulfide	237-240	cystathionine beta-synthase	Mus musculus	135-162
23133623-13	2012	Intraperitoneal injection (i.p) of DL-propargylglycine, an irreversible inhibitor of CSE, and aminooxyacetic acid, an inhibitor of CBS, elevated the expression of TNF-alpha mRNA in the tunica muscularis of the ileum.	Aminooxyacetic Acid	94-113	cystathionine beta-synthase	Mus musculus	131-134
22232681-3	2012	In this cascade, hypoxia elicits cerebral vasodilation via the coordinate actions of H(2)S formed by cystathionine beta-synthase (CBS) and CO generated by heme oxygenase (HO)-2.	Hydrogen Sulfide	85-90	cystathionine beta-synthase	Mus musculus	101-128
22232681-3	2012	In this cascade, hypoxia elicits cerebral vasodilation via the coordinate actions of H(2)S formed by cystathionine beta-synthase (CBS) and CO generated by heme oxygenase (HO)-2.	Hydrogen Sulfide	85-90	cystathionine beta-synthase	Mus musculus	130-133
23071662-8	2012	The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine beta-synthase inhibitor, D,L-propargylglycine (PAG), which inhibits H(2)S formation.	Cysteine	27-37	cystathionine beta-synthase	Mus musculus	76-103
23071662-8	2012	The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine beta-synthase inhibitor, D,L-propargylglycine (PAG), which inhibits H(2)S formation.	DL-Propargylglycine	115-135	cystathionine beta-synthase	Mus musculus	76-103
23071662-8	2012	The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine beta-synthase inhibitor, D,L-propargylglycine (PAG), which inhibits H(2)S formation.	pag	137-140	cystathionine beta-synthase	Mus musculus	76-103
23071662-8	2012	The sensitizing effects of L-cysteine in wild-type mice were inhibited by a cystathionine beta-synthase inhibitor, D,L-propargylglycine (PAG), which inhibits H(2)S formation.	Hydrogen Sulfide	158-163	cystathionine beta-synthase	Mus musculus	76-103
22396778-1	2012	Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Mus musculus	146-173
22396778-1	2012	Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	86-96	cystathionine beta-synthase	Mus musculus	146-173
22396778-1	2012	Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5"-phosphate-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Pyridoxal Phosphate	104-126	cystathionine beta-synthase	Mus musculus	146-173
21941612-4	2011	The hypothesis was that homocysteine (Hcy) decreased thioredoxin (Trx), peroxiredoxin (Prx), increased NADPH oxidase (NOX1), mitochondrial nitric oxide synthase (mtNOS) activity and reactive oxygen species (ROS) in mitochondria in a CBS gene dose-dependent manner.	Homocysteine	24-36	cystathionine beta-synthase	Mus musculus	233-236
22047765-2	2011	Western blotting and immunocytochemistry were used to determine expression levels of the H2S-producing enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) in gastric tissues and cultured smooth muscle cells.	Hydrogen Sulfide	89-92	cystathionine beta-synthase	Mus musculus	111-138
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Homocysteine	87-99	cystathionine beta-synthase	Mus musculus	0-27
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Homocysteine	87-99	cystathionine beta-synthase	Mus musculus	29-32
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Cysteine	91-99	cystathionine beta-synthase	Mus musculus	0-27
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Cysteine	91-99	cystathionine beta-synthase	Mus musculus	29-32
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Cysteine	103-111	cystathionine beta-synthase	Mus musculus	0-27
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Cysteine	103-111	cystathionine beta-synthase	Mus musculus	29-32
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Glutathione	172-183	cystathionine beta-synthase	Mus musculus	0-27
22021075-3	2011	Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis.	Glutathione	172-183	cystathionine beta-synthase	Mus musculus	29-32
22021075-7	2011	However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice.	Glucose	61-68	cystathionine beta-synthase	Mus musculus	9-12
22021075-7	2011	However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice.	Glutathione	109-120	cystathionine beta-synthase	Mus musculus	9-12
22021075-7	2011	However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice.	Cysteine	170-178	cystathionine beta-synthase	Mus musculus	9-12
22021075-8	2011	Higher triglyceride concentrations, increased oxidative stress, and increased markers of apoptosis were also observed in heart from Cbs(+/-) mice with diet-induced obesity compared with Cbs(+/+) mice.	Triglycerides	7-19	cystathionine beta-synthase	Mus musculus	132-135
22021075-9	2011	This study suggests a novel role for Cbs in maintaining the cardiac glutathione pool and protecting against cardiac lipid accumulation and oxidative stress during diet-induced obesity in mice.	Glutathione	68-79	cystathionine beta-synthase	Mus musculus	37-40
21898591-0	2011	1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine beta-synthase.	Calcitriol	0-24	cystathionine beta-synthase	Mus musculus	130-157
21898591-0	2011	1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine beta-synthase.	Homocysteine	45-57	cystathionine beta-synthase	Mus musculus	130-157
21898591-3	2011	HCY is cleared by cystathionine beta-synthase (CBS), the first enzyme in the transsulfuration pathway.	Homocysteine	0-3	cystathionine beta-synthase	Mus musculus	18-45
21898591-3	2011	HCY is cleared by cystathionine beta-synthase (CBS), the first enzyme in the transsulfuration pathway.	Homocysteine	0-3	cystathionine beta-synthase	Mus musculus	47-50
21898591-4	2011	CBS converts HCY to cystathionine, thereby committing it to cysteine synthesis.	Homocysteine	13-16	cystathionine beta-synthase	Mus musculus	0-3
21898591-4	2011	CBS converts HCY to cystathionine, thereby committing it to cysteine synthesis.	Cystathionine	20-33	cystathionine beta-synthase	Mus musculus	0-3
21898591-4	2011	CBS converts HCY to cystathionine, thereby committing it to cysteine synthesis.	Cysteine	60-68	cystathionine beta-synthase	Mus musculus	0-3
21898591-5	2011	A microarray experiment on MC3T3-E1 murine preosteoblasts treated with 1,25-dihydroxyvitamin D(3) [1,25(OH)(2) D(3) ] revealed a cluster of genes including the cbs gene, of which the transcription was rapidly and strongly induced by 1,25(OH)(2) D(3) .	1,25-dihydroxyvitamin D	71-94	cystathionine beta-synthase	Mus musculus	160-163
21898591-9	2011	Chromatin immunoprecipitation on chip and transfection studies revealed a functional vitamin D response element in the second intron of cbs.	Vitamin D	85-94	cystathionine beta-synthase	Mus musculus	136-139
21857260-10	2011	Sulfide and hypothermia also attenuated the trauma-induced cystathionine-beta synthase and cystathionine-gamma lyase expression.	Sulfides	0-7	cystathionine beta-synthase	Mus musculus	59-86
21857260-13	2011	The simultaneous reduction in cystathionine-beta synthase and cystathionine-gamma lyase expression supports the role of H2S-generating enzymes as an adaptive response during stress states.	Hydrogen Sulfide	120-123	cystathionine beta-synthase	Mus musculus	30-57
21941612-4	2011	The hypothesis was that homocysteine (Hcy) decreased thioredoxin (Trx), peroxiredoxin (Prx), increased NADPH oxidase (NOX1), mitochondrial nitric oxide synthase (mtNOS) activity and reactive oxygen species (ROS) in mitochondria in a CBS gene dose-dependent manner.	Homocysteine	38-41	cystathionine beta-synthase	Mus musculus	233-236
21941612-14	2011	In addition, CZ restored the PPARgamma activity in CBS-/+ and -/- mice to normal levels.	ciglitazone	13-15	cystathionine beta-synthase	Mus musculus	51-54
21941612-18	2011	The data support the notion that Hcy decreases redoxins, increases mtNOS activity and ROS/oxidase in mitochondrial mitophagy in a gene dose-dependent manner of CBS.	Homocysteine	33-36	cystathionine beta-synthase	Mus musculus	160-163
21941612-18	2011	The data support the notion that Hcy decreases redoxins, increases mtNOS activity and ROS/oxidase in mitochondrial mitophagy in a gene dose-dependent manner of CBS.	redoxins	47-55	cystathionine beta-synthase	Mus musculus	160-163
21185709-4	2011	In a previous study we have shown a beneficial effect of a red wine polyphenolic extract (PE) administration on plasma homocysteine level in cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.	Homocysteine	119-131	cystathionine beta-synthase	Mus musculus	141-168
21185709-7	2011	PE was added for four weeks to the drinking water of heterozygous cystathionine beta synthase-deficient mice fed a high-methionine diet.	pe	0-2	cystathionine beta-synthase	Mus musculus	66-93
21254839-1	2011	The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule.	Hydrogen Sulfide	163-179	cystathionine beta-synthase	Mus musculus	45-72
21254839-1	2011	The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule.	Hydrogen Sulfide	163-179	cystathionine beta-synthase	Mus musculus	74-77
21254839-1	2011	The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule.	Hydrogen Sulfide	181-186	cystathionine beta-synthase	Mus musculus	45-72
21254839-1	2011	The enzymes of the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are important for the endogenous production of hydrogen sulfide (H(2)S), a gaseous signaling molecule.	Hydrogen Sulfide	181-186	cystathionine beta-synthase	Mus musculus	74-77
21254839-3	2011	In this study, we report quantification of CBS and CSE in murine liver and kidney and their contribution to H(2)S generation in these tissues and in brain at saturating substrate concentrations.	Hydrogen Sulfide	108-113	cystathionine beta-synthase	Mus musculus	43-46
21254839-6	2011	At high substrate concentrations (20 mM each cysteine and homocysteine), the capacity for liver H(2)S production is approximately equal for CBS and CSE, whereas in kidney and brain, CBS constitutes the major source of H(2)S, accounting for ~80% and ~95%, respectively, of the total output.	Hydrogen Sulfide	96-101	cystathionine beta-synthase	Mus musculus	140-143
21254839-6	2011	At high substrate concentrations (20 mM each cysteine and homocysteine), the capacity for liver H(2)S production is approximately equal for CBS and CSE, whereas in kidney and brain, CBS constitutes the major source of H(2)S, accounting for ~80% and ~95%, respectively, of the total output.	Hydrogen Sulfide	218-223	cystathionine beta-synthase	Mus musculus	182-185
21254839-7	2011	At physiologically relevant concentrations of substrate, and adjusting for the differences in CBS versus CSE levels, we estimate that CBS accounts for only 3% of H(2)S production by the transsulfuration pathway enzymes in liver.	Hydrogen Sulfide	162-167	cystathionine beta-synthase	Mus musculus	134-137
20981572-8	2011	RESULTS: The mRNA expression levels of CSE and CBS, and the H(2)S content in the colonic mucosa were increased with time after DSS administration.	dss	127-130	cystathionine beta-synthase	Mus musculus	47-50
22096601-1	2011	Cystathionine beta synthase (CBS) is the rate-limiting enzyme responsible for the de novo synthesis of cysteine.	Cysteine	103-111	cystathionine beta-synthase	Mus musculus	0-27
20955694-0	2011	Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.	Homocysteine	111-123	cystathionine beta-synthase	Mus musculus	55-82
20955694-0	2011	Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.	Hydrogen Sulfide	128-144	cystathionine beta-synthase	Mus musculus	55-82
20955694-4	2011	Cystathionine beta-synthase (CBS) has been shown to catalyze H(2)S production in vitro.	Hydrogen Sulfide	61-66	cystathionine beta-synthase	Mus musculus	0-27
20955694-4	2011	Cystathionine beta-synthase (CBS) has been shown to catalyze H(2)S production in vitro.	Hydrogen Sulfide	61-66	cystathionine beta-synthase	Mus musculus	29-32
20955694-5	2011	CBS enzyme activity is allosterically regulated by the endogenous activator S-adenosyl methionine.	S-Adenosylmethionine	78-97	cystathionine beta-synthase	Mus musculus	0-3
20955694-6	2011	This mode of regulation suggests the possibility for designing a small molecule activator of CBS to enhance H(2)S production.	Hydrogen Sulfide	108-113	cystathionine beta-synthase	Mus musculus	93-96
20955694-8	2011	We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels.	Hydrogen Sulfide	62-67	cystathionine beta-synthase	Mus musculus	18-21
20955694-8	2011	We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels.	Hydrogen Sulfide	62-67	cystathionine beta-synthase	Mus musculus	127-130
20955694-8	2011	We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels.	Hydrogen Sulfide	190-195	cystathionine beta-synthase	Mus musculus	18-21
20955694-8	2011	We show here that CBS contributes significantly to endogenous H(2)S production in mice: adenovirus mediated over expression of CBS in the liver significantly increased circulating levels of H(2)S, whereas CBS deficiency resulted in reduced levels.	Hydrogen Sulfide	190-195	cystathionine beta-synthase	Mus musculus	127-130
20955694-9	2011	We demonstrate that CBS enzyme from endogenous sources can be activated by S-adenosyl methionine to a greater extent compared to recombinant enzyme, suggesting greater potential for activation than previously anticipated.	S-Adenosylmethionine	75-96	cystathionine beta-synthase	Mus musculus	20-23
20955694-10	2011	Importantly, we show that circulating H(2)S levels are increased by pharmacological activation of CBS in vivo; i.e. in the presence of the endogenous activator.	Hydrogen Sulfide	38-43	cystathionine beta-synthase	Mus musculus	98-101
20955694-11	2011	Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases.	Hydrogen Sulfide	80-85	cystathionine beta-synthase	Mus musculus	36-39
20955694-11	2011	Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases.	Hydrogen Sulfide	80-85	cystathionine beta-synthase	Mus musculus	142-145
20955694-11	2011	Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases.	Hydrogen Sulfide	209-214	cystathionine beta-synthase	Mus musculus	36-39
20955694-11	2011	Together, our data demonstrate that CBS activity partially regulates endogenous H(2)S in mice, and suggest that pharmacological activation of CBS is a promising approach for enhancing endogenous production of H(2)S for the treatment of cardiovascular and other diseases.	Hydrogen Sulfide	209-214	cystathionine beta-synthase	Mus musculus	142-145
20943958-0	2011	Cystathionine beta-synthase and cystathionine gamma-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation.	Hydrogen Sulfide	143-159	cystathionine beta-synthase	Mus musculus	0-27
22096601-6	2011	Although NAC treatment in TgI278T Cbs(-/-) mice caused significant increase in serum tCys and liver GSH, there was no increase in body fat content or in liver Scd-1 levels.	Acetylcysteine	9-12	cystathionine beta-synthase	Mus musculus	34-37
22096601-6	2011	Although NAC treatment in TgI278T Cbs(-/-) mice caused significant increase in serum tCys and liver GSH, there was no increase in body fat content or in liver Scd-1 levels.	tcys	85-89	cystathionine beta-synthase	Mus musculus	34-37
22096601-6	2011	Although NAC treatment in TgI278T Cbs(-/-) mice caused significant increase in serum tCys and liver GSH, there was no increase in body fat content or in liver Scd-1 levels.	Glutathione	100-103	cystathionine beta-synthase	Mus musculus	34-37
22096601-1	2011	Cystathionine beta synthase (CBS) is the rate-limiting enzyme responsible for the de novo synthesis of cysteine.	Cysteine	103-111	cystathionine beta-synthase	Mus musculus	29-32
20036517-0	2010	Methionine-deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase.	Methionine	0-10	cystathionine beta-synthase	Mus musculus	73-100
20512599-4	2010	Here, we identify a novel metabolite, Nepsilon-Hcy-Lys, in human and mouse plasma, and show that this metabolite is elevated in genetic (cystathionine beta-synthase deficiency in humans and mice, methylenetetrahydrofolate reductase deficiency in mice) or dietary (high Met diet in mice) deficiencies in Hcy metabolism.	Homocysteine	47-50	cystathionine beta-synthase	Mus musculus	137-164
20512599-4	2010	Here, we identify a novel metabolite, Nepsilon-Hcy-Lys, in human and mouse plasma, and show that this metabolite is elevated in genetic (cystathionine beta-synthase deficiency in humans and mice, methylenetetrahydrofolate reductase deficiency in mice) or dietary (high Met diet in mice) deficiencies in Hcy metabolism.	Lysine	51-54	cystathionine beta-synthase	Mus musculus	137-164
20036517-2	2010	Homocysteine is formed from methionine and has two primary metabolic fates: remethylation to form methionine or commitment to the transsulfuration pathway by the action of cystathionine beta-synthase (CBS).	Homocysteine	0-12	cystathionine beta-synthase	Mus musculus	172-199
20036517-2	2010	Homocysteine is formed from methionine and has two primary metabolic fates: remethylation to form methionine or commitment to the transsulfuration pathway by the action of cystathionine beta-synthase (CBS).	Homocysteine	0-12	cystathionine beta-synthase	Mus musculus	201-204
20036517-5	2010	Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity.	thcy	34-38	cystathionine beta-synthase	Mus musculus	8-11
20036517-5	2010	Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity.	Methionine	104-114	cystathionine beta-synthase	Mus musculus	8-11
20036517-5	2010	Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity.	Methionine	104-114	cystathionine beta-synthase	Mus musculus	52-55
20036517-8	2010	CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein.	Methionine	35-45	cystathionine beta-synthase	Mus musculus	271-274
20036517-8	2010	CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein.	Methionine	93-103	cystathionine beta-synthase	Mus musculus	271-274
20036517-8	2010	CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein.	S-Adenosylmethionine	189-209	cystathionine beta-synthase	Mus musculus	271-274
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Catechin	58-66	cystathionine beta-synthase	Mus musculus	155-182
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Cysteine	68-76	cystathionine beta-synthase	Mus musculus	29-32
20638882-5	2010	Betaine treatment did improve survival of cbs (-/-) mice and restored fertility to female cbs (-/-) mice but did so without significantly lowering Hcy levels.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	42-45
20638882-5	2010	Betaine treatment did improve survival of cbs (-/-) mice and restored fertility to female cbs (-/-) mice but did so without significantly lowering Hcy levels.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	90-93
20067586-3	2010	Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine.	Hydrogen Sulfide	134-139	cystathionine beta-synthase	Mus musculus	0-27
20067586-3	2010	Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine.	(e)ine	149-155	cystathionine beta-synthase	Mus musculus	0-27
19858416-8	2009	These changes were exacerbated in Tg-S466L Cbs(-/-) mice with aging.	Thioguanine	34-36	cystathionine beta-synthase	Mus musculus	43-46
19932868-0	2009	Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	36-63
19932868-0	2009	Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	89-116
19932868-2	2009	Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content.	Cysteine	36-44	cystathionine beta-synthase	Mus musculus	8-11
19932868-2	2009	Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content.	Taurine	49-56	cystathionine beta-synthase	Mus musculus	8-11
19932868-2	2009	Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content.	Taurocholic Acid	129-145	cystathionine beta-synthase	Mus musculus	8-11
19932868-2	2009	Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content.	Cholesterol	184-195	cystathionine beta-synthase	Mus musculus	8-11
19932868-3	2009	We hypothesized that a deficiency in CBS genetic material and enzyme activity would reduce taurine synthesis, which would lead to an elevated cholesterol concentration.	Taurine	91-98	cystathionine beta-synthase	Mus musculus	37-40
19932868-3	2009	We hypothesized that a deficiency in CBS genetic material and enzyme activity would reduce taurine synthesis, which would lead to an elevated cholesterol concentration.	Cholesterol	142-153	cystathionine beta-synthase	Mus musculus	37-40
19932868-6	2009	Significantly higher plasma total homocysteine concentrations occurred in the CBS (+/-) mice than their CBS (+/+) cohorts.	Homocysteine	34-46	cystathionine beta-synthase	Mus musculus	78-81
19357353-0	2009	Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.	Homocysteine	24-36	cystathionine beta-synthase	Mus musculus	73-100
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	52-54	cystathionine beta-synthase	Mus musculus	61-64
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	52-54	cystathionine beta-synthase	Mus musculus	287-290
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Homocysteine	127-139	cystathionine beta-synthase	Mus musculus	61-64
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	279-281	cystathionine beta-synthase	Mus musculus	61-64
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Hexachlorobenzene	282-286	cystathionine beta-synthase	Mus musculus	61-64
18987302-6	2009	RNA profiling of livers indicate that Tg-I278T Cbs(-/-) and Tg-hCBS Cbs(-/-) mice have unique gene signatures, with minimal overlap.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
18987302-6	2009	RNA profiling of livers indicate that Tg-I278T Cbs(-/-) and Tg-hCBS Cbs(-/-) mice have unique gene signatures, with minimal overlap.	Hexachlorobenzene	63-67	cystathionine beta-synthase	Mus musculus	68-71
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Homocysteine	64-76	cystathionine beta-synthase	Mus musculus	0-27
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Homocysteine	64-76	cystathionine beta-synthase	Mus musculus	29-32
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Homocysteine	78-81	cystathionine beta-synthase	Mus musculus	0-27
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Homocysteine	78-81	cystathionine beta-synthase	Mus musculus	29-32
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Serine	87-93	cystathionine beta-synthase	Mus musculus	0-27
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Serine	87-93	cystathionine beta-synthase	Mus musculus	29-32
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Cystathionine	97-110	cystathionine beta-synthase	Mus musculus	0-27
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Cystathionine	97-110	cystathionine beta-synthase	Mus musculus	29-32
20638879-1	2010	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase.	Cysteine	68-76	cystathionine beta-synthase	Mus musculus	0-27
19957376-0	2010	Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse.	Ethanol	78-85	cystathionine beta-synthase	Mus musculus	90-117
19957376-6	2010	The chromatin immunoprecipitation assay revealed a decrease in levels of suppressor chromatin marker 3meH3K9 in the promoter regions of GRP78, SREBP-1c, and GADD153 in ethanol-treated heterozygous cystathionine beta synthase mice.	Ethanol	168-175	cystathionine beta-synthase	Mus musculus	197-224
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Niacinamide	85-94	cystathionine beta-synthase	Mus musculus	61-64
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Niacinamide	85-94	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Niacinamide	85-94	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Niacinamide	85-94	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Cholesterol	152-163	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Cholesterol	152-163	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Cholesterol	152-163	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107
19932868-10	2009	We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA.	Taurine	81-88	cystathionine beta-synthase	Mus musculus	31-34
19932868-10	2009	We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA.	Taurine	81-88	cystathionine beta-synthase	Mus musculus	126-129
18855522-2	2009	Currently, pyridoxal-5"-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain.	Pyridoxal Phosphate	11-33	cystathionine beta-synthase	Mus musculus	50-77
18855522-2	2009	Currently, pyridoxal-5"-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain.	Hydrogen Sulfide	111-116	cystathionine beta-synthase	Mus musculus	50-77
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Catechin	58-66	cystathionine beta-synthase	Mus musculus	184-187
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Homocysteine	133-145	cystathionine beta-synthase	Mus musculus	155-182
19028542-3	2009	We have recently demonstrated that the supplementation of catechin, a polyphenol found in the red wine, significantly reduced plasma homocysteine level in cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Homocysteine	133-145	cystathionine beta-synthase	Mus musculus	184-187
19021146-7	2009	In CBS-/+ mice, homocysteine was elevated and in iNOS-/- mice, nitric oxide was significantly reduced.	Homocysteine	16-28	cystathionine beta-synthase	Mus musculus	3-6
19085910-0	2009	Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion.	Carbon Monoxide	33-48	cystathionine beta-synthase	Mus musculus	0-27
19085910-3	2009	Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it.	Carbon Monoxide	45-47	cystathionine beta-synthase	Mus musculus	26-29
19085910-3	2009	Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it.	Heme	72-76	cystathionine beta-synthase	Mus musculus	26-29
19085910-3	2009	Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it.	Histidine	114-123	cystathionine beta-synthase	Mus musculus	26-29
19085910-3	2009	Studies using recombinant CBS indicated that CO binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity, whereas nitric oxide (NO) forms 5-coordinated structure without inhibiting it.	Nitric Oxide	163-175	cystathionine beta-synthase	Mus musculus	26-29
19085910-5	2009	Livers of heterozygous CBS knockout mice neither down-regulated H(2)S nor exhibited the choleresis while overproducing CO.	Hydrogen Sulfide	64-69	cystathionine beta-synthase	Mus musculus	23-26
19085910-7	2009	CONCLUSION: Results collected from metabolome analyses suggested that CBS serves as a CO-sensitive modulator of H(2)S to support biliary excretion, shedding light on a putative role of the enzyme for stress-elicited adaptive response against bile-dependent detoxification processes.	Hydrogen Sulfide	112-117	cystathionine beta-synthase	Mus musculus	70-73
19021146-8	2009	The nitrotyrosine and matrix metalloproteinase-9 (MMP-9) levels were elevated in double knockout and CBS-/+ as compared to WT mice.	3-nitrotyrosine	4-17	cystathionine beta-synthase	Mus musculus	101-104
18725259-10	2008	Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice.	gamma-Aminobutyric Acid	83-87	cystathionine beta-synthase	Mus musculus	72-75
20407615-2	2009	We reported recently that mice with endogenous hyperhomocysteinemia, due to mutation of the cystathionine-beta-synthase (cbs) gene, demonstrate loss of neurons in the retinal ganglion cell (RGC) layer and other retinal layers as homocysteine levels increase.	Homocysteine	52-64	cystathionine beta-synthase	Mus musculus	92-119
18541157-0	2008	Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.	Hydrogen Peroxide	65-82	cystathionine beta-synthase	Mus musculus	0-27
18725259-3	2008	Homozygous individuals for (CBS-/-) die early, but heterozygous for (CBS-/+) survive with high levels of Hcy.	Homocysteine	105-108	cystathionine beta-synthase	Mus musculus	69-72
18725259-10	2008	Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice.	gamma-Aminobutyric Acid	43-47	cystathionine beta-synthase	Mus musculus	36-39
18725259-10	2008	Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice.	gamma-Aminobutyric Acid	43-47	cystathionine beta-synthase	Mus musculus	72-75
18725259-10	2008	Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice.	gamma-Aminobutyric Acid	83-87	cystathionine beta-synthase	Mus musculus	36-39
18547546-1	2008	Individuals with homozygous deficiency in cystathionine-beta-synthase (CBS) develop high levels of homocysteine in plasma, a condition known as homocysteinuria.	Homocysteine	99-111	cystathionine beta-synthase	Mus musculus	42-69
17971175-0	2007	Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice.	Homocysteine	0-12	cystathionine beta-synthase	Mus musculus	38-65
18224302-0	2008	Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine beta-synthase and apolipoprotein A-I.	Simvastatin	0-11	cystathionine beta-synthase	Mus musculus	67-94
17971175-6	2007	RESULTS: Among the animals used in this study, we observed a negative correlation between plasma homocysteine level and cystathionine beta synthase activity (rho=-0.52, P=0.0008) or paraoxonase 1 activity (rho=-0.49, P=0.002).	Homocysteine	97-109	cystathionine beta-synthase	Mus musculus	120-147
17971175-7	2007	Starting from these results, a homocysteine cut-off value of 15 microm has been found for both cystathionine beta synthase (P=0.0003) and paraoxonase 1 (P=0.0007) activities.	Homocysteine	31-43	cystathionine beta-synthase	Mus musculus	95-122
17971175-8	2007	CONCLUSIONS: Our results suggest that both cystathionine beta synthase and paraoxonase 1 activities are significantly decreased in mice with a plasma homocysteine value greater than 15 microm.	Homocysteine	150-162	cystathionine beta-synthase	Mus musculus	43-70
17537983-4	2007	Renal function is known to be an important determinant of tHcy, and, in this study, we demonstrate that renal CBS expression and activity in mice diminished approximately twofold after castration, whereas ovariectomization was without effect.	thcy	58-62	cystathionine beta-synthase	Mus musculus	110-113
17543941-1	2007	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	0-27
17543941-1	2007	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	29-32
17537983-5	2007	The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005).	Cystathionine	123-136	cystathionine beta-synthase	Mus musculus	17-20
17853447-1	2007	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	109-136
17853447-1	2007	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	138-141
17853447-1	2007	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Mus musculus	109-136
17853447-1	2007	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Mus musculus	138-141
17853447-11	2007	In conclusion, both CBS and CGL are present in the amphibian retina, which suggests either a potential role for H(2)S as a gaseous neuromodulator in both neurons and glia in the retina or a requirement for cysteine and glutathione synthesis via the transsulfuration pathway as a defense against oxidative stress.	Hydrogen Sulfide	112-117	cystathionine beta-synthase	Mus musculus	20-23
17537983-5	2007	The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005).	thcy	228-232	cystathionine beta-synthase	Mus musculus	17-20
17537983-5	2007	The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005).	Cystathionine	58-71	cystathionine beta-synthase	Mus musculus	17-20
17461778-7	2007	The conversion of homocysteine into cystathionine, a rate-limiting step in trans-sulfuration catalysed by cystathionine beta-synthase, was comparatively less efficient in the old mice, as indicated by cystathionine/homocysteine ratios.	Homocysteine	18-30	cystathionine beta-synthase	Mus musculus	106-133
17461778-7	2007	The conversion of homocysteine into cystathionine, a rate-limiting step in trans-sulfuration catalysed by cystathionine beta-synthase, was comparatively less efficient in the old mice, as indicated by cystathionine/homocysteine ratios.	Cystathionine	36-49	cystathionine beta-synthase	Mus musculus	106-133
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Cysteine	75-83	cystathionine beta-synthase	Mus musculus	0-3
17562377-0	2007	Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.	Homocysteine	62-74	cystathionine beta-synthase	Mus musculus	18-45
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Vitamin B 6	9-19	cystathionine beta-synthase	Mus musculus	0-3
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Methionine	89-99	cystathionine beta-synthase	Mus musculus	0-3
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Serine	132-138	cystathionine beta-synthase	Mus musculus	0-3
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Homocysteine	144-156	cystathionine beta-synthase	Mus musculus	0-3
17663144-1	2007	CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine.	Cystathionine	165-178	cystathionine beta-synthase	Mus musculus	0-3
17663144-10	2007	Moreover, CBS was significantly accumulated in reactive astrocytes in the hippocampus after kainic acid-induced seizures, and cerebellar morphological abnormalities were observed in CBS-deficient mice.	Kainic Acid	92-103	cystathionine beta-synthase	Mus musculus	10-13
17561372-0	2007	Cystathionine beta synthase participates in murine oocyte maturation mediated by homocysteine.	Homocysteine	81-93	cystathionine beta-synthase	Mus musculus	0-27
17561372-4	2007	Accompanied with a gradual increase of homocysteine, the introduction of CBS-siRNA into murine granulosa cells selectively depleted the corresponding target mRNA and protein for CBS as assessed by semi-quantitative reverse-transcriptase PCR (RT-PCR) and immunofluorescence staining.	Homocysteine	39-51	cystathionine beta-synthase	Mus musculus	73-76
17561372-4	2007	Accompanied with a gradual increase of homocysteine, the introduction of CBS-siRNA into murine granulosa cells selectively depleted the corresponding target mRNA and protein for CBS as assessed by semi-quantitative reverse-transcriptase PCR (RT-PCR) and immunofluorescence staining.	Homocysteine	39-51	cystathionine beta-synthase	Mus musculus	178-181
17292331-1	2007	We have recently focused on the interaction between hyperhomocysteinemia, defined by high plasma homocysteine levels, and paraoxonase-1 expression and found a reduced activity of paraoxonase-1 associated with a reduced gene expression in the liver of cystathionine beta synthase (CBS) deficient mice, a murine model of hyperhomocysteinemia.	Homocysteine	57-69	cystathionine beta-synthase	Mus musculus	251-278
17292331-4	2007	However, chronic administration of catechin but not quercetin significantly reduced plasma homocysteine levels, attenuated the reduction of the hepatic CBS activity, and restored the decreased paraoxonase-1 gene expression and activity induced by chronic hyperhomocysteinemia.	Catechin	35-43	cystathionine beta-synthase	Mus musculus	152-155
17202841-9	2006	In CBS-/- mice treated with rAAV-hCBS via IP injection, the vector was detected in all organs examined including liver, spleen, and kidney, and CBS gene expression was observed by immunohistochemical staining in the liver.	raav-hcbs	28-37	cystathionine beta-synthase	Mus musculus	3-6
17488480-1	2007	Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	0-17	cystathionine beta-synthase	Mus musculus	111-138
17488480-1	2007	Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	19-24	cystathionine beta-synthase	Mus musculus	111-138
17488480-1	2007	Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS).	Cysteine	46-56	cystathionine beta-synthase	Mus musculus	111-138
17937607-3	2007	Deficiencies in cystathionine beta-synthase lead to elevated plasma methionine, while deficiencies of the remaining three enzymes lead to hypomethioninemia.	Methionine	68-78	cystathionine beta-synthase	Mus musculus	16-43
17360897-10	2007	Remarkably, hyperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-methionine, low-folate diet is associated with increased brain S-adenosylhomocysteine levels, PPMT downregulation, reduced PP2A methylation levels, and tau and APP phosphorylation.	Methionine	113-123	cystathionine beta-synthase	Mus musculus	58-85
17360897-10	2007	Remarkably, hyperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-methionine, low-folate diet is associated with increased brain S-adenosylhomocysteine levels, PPMT downregulation, reduced PP2A methylation levels, and tau and APP phosphorylation.	Folic Acid	129-135	cystathionine beta-synthase	Mus musculus	58-85
16815886-4	2006	To decrease plasma Hcy, dietary supplementation with 3-deazaadenosine (DZA), the S-adenosylhomocysteine hydrolase inhibitor, was administered to cystathionine beta-synthase (CBS) knockout (KO) mice.	3-deazaadenosine	53-69	cystathionine beta-synthase	Mus musculus	145-172
16644696-3	2006	Cystathionine beta-synthase and cystathionine gamma-lyase, both of which can produce H(2)S, were expressed in mouse pancreatic islet cells and the beta-cell line, MIN6.	Hydrogen Sulfide	85-90	cystathionine beta-synthase	Mus musculus	0-27
16210565-3	2005	METHODS AND RESULTS: Through the use of 2 functional models, aortic rings and intravital video microscopy of the cremaster, we found that arterial relaxation in response to the endothelium-dependent vessel relaxant, acetylcholine or the nitric oxide synthase (NOS) activator (A23187), was significantly impaired in cystathionine beta-synthase null (CBS(-/-)) mice.	Acetylcholine	216-229	cystathionine beta-synthase	Mus musculus	315-342
15887121-1	2005	BACKGROUND & AIMS: Cystathionine beta-synthase (CBS) deficiency causes severe hyperhomocysteinemia, which confers diverse clinical manifestations, notably liver disease.	Adenosine Monophosphate	12-15	cystathionine beta-synthase	Mus musculus	23-50
16160063-1	2005	Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine.	Cysteine	84-92	cystathionine beta-synthase	Mus musculus	0-27
16160063-1	2005	Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine.	Cysteine	84-92	cystathionine beta-synthase	Mus musculus	29-32
16160063-1	2005	Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine.	Methionine	98-108	cystathionine beta-synthase	Mus musculus	0-27
16160063-1	2005	Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine.	Methionine	98-108	cystathionine beta-synthase	Mus musculus	29-32
16160063-7	2005	CBS was most highly expressed in juvenile brain, and a striking induction was observed in cultured astrocytes in response to EGF, TGF-alpha, cAMP, and dexamethasone.	Cyclic AMP	141-145	cystathionine beta-synthase	Mus musculus	0-3
16160063-7	2005	CBS was most highly expressed in juvenile brain, and a striking induction was observed in cultured astrocytes in response to EGF, TGF-alpha, cAMP, and dexamethasone.	Dexamethasone	151-164	cystathionine beta-synthase	Mus musculus	0-3
16160063-8	2005	Moreover, CBS was significantly accumulated in reactive astrocytes in the hippocampus after kainic acid-induced seizures, and cerebellar morphological abnormalities were observed in CBS-deficient mice.	Kainic Acid	92-103	cystathionine beta-synthase	Mus musculus	10-13
15555590-10	2004	Additionally, active CBS is essential for the formation of CysAlb.	cysalb	59-65	cystathionine beta-synthase	Mus musculus	21-24
15622513-1	2005	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	0-27
15622513-1	2005	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	29-32
15916860-3	2005	Here we show an activation of the extracellular signal-regulated kinases (ERK1 and ERK2) and the downstream nuclear targets Elk-1 and calcium/cAMP response element binding protein, in the hippocampus of cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.	Calcium	134-141	cystathionine beta-synthase	Mus musculus	203-230
15916860-3	2005	Here we show an activation of the extracellular signal-regulated kinases (ERK1 and ERK2) and the downstream nuclear targets Elk-1 and calcium/cAMP response element binding protein, in the hippocampus of cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.	Cyclic AMP	142-146	cystathionine beta-synthase	Mus musculus	203-230
15386278-1	2004	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	0-27
15466479-1	2004	Hyperhomocysteinemia (HHCY) is a consequence of impaired methionine/cysteine metabolism and is caused by deficiency of vitamins and/or enzymes such as cystathionine beta-synthase (CBS).	Cysteine	9-17	cystathionine beta-synthase	Mus musculus	151-178
15466479-1	2004	Hyperhomocysteinemia (HHCY) is a consequence of impaired methionine/cysteine metabolism and is caused by deficiency of vitamins and/or enzymes such as cystathionine beta-synthase (CBS).	Cysteine	9-17	cystathionine beta-synthase	Mus musculus	180-183
15466479-5	2004	Triglyceride and nonesterified fatty acid levels were markedly elevated in CBS(-/-) mouse liver and serum.	Triglycerides	0-12	cystathionine beta-synthase	Mus musculus	75-78
15466479-5	2004	Triglyceride and nonesterified fatty acid levels were markedly elevated in CBS(-/-) mouse liver and serum.	Fatty Acids, Nonesterified	17-41	cystathionine beta-synthase	Mus musculus	75-78
15466479-6	2004	The activity of thiolase, a key enzyme in beta-oxidation of fatty acids, was significantly impaired in CBS(-/-) mouse liver.	Fatty Acids	60-71	cystathionine beta-synthase	Mus musculus	103-106
15466479-9	2004	Abnormal high density lipoprotein particles with higher mobility in polyacrylamide gel electrophoresis were observed in serum obtained from CBS(-/-) mice.	polyacrylamide	68-82	cystathionine beta-synthase	Mus musculus	140-143
15466479-10	2004	Moreover, serum cholesterol/triglyceride distribution in lipoprotein fractions was altered in CBS(-/-) mice.	Cholesterol	16-27	cystathionine beta-synthase	Mus musculus	94-97
15466479-10	2004	Moreover, serum cholesterol/triglyceride distribution in lipoprotein fractions was altered in CBS(-/-) mice.	Triglycerides	28-40	cystathionine beta-synthase	Mus musculus	94-97
15297456-7	2004	Whereas UNG expression is significantly higher in proliferating as compared with nonproliferating cells, such as neurons, the levels of UNG mRNA were increased in brains of cystathionine beta-synthase knockout mice, a model for hyperhomocysteinemia, suggesting that one-carbon metabolism impairment and uracil misincorporation can induce the up-regulation of UNG expression.	Carbon	270-276	cystathionine beta-synthase	Mus musculus	173-200
15297456-7	2004	Whereas UNG expression is significantly higher in proliferating as compared with nonproliferating cells, such as neurons, the levels of UNG mRNA were increased in brains of cystathionine beta-synthase knockout mice, a model for hyperhomocysteinemia, suggesting that one-carbon metabolism impairment and uracil misincorporation can induce the up-regulation of UNG expression.	Uracil	303-309	cystathionine beta-synthase	Mus musculus	173-200
15386278-1	2004	Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine.	Homocysteine	85-97	cystathionine beta-synthase	Mus musculus	29-32
15105297-0	2004	Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice.	Homocysteine	70-82	cystathionine beta-synthase	Mus musculus	14-41
15016621-5	2004	Homozygous disruption of Cbs lowered cysteine concentration in all three organs.	Cysteine	37-45	cystathionine beta-synthase	Mus musculus	25-28
15016621-9	2004	These studies provide evidence that homozygous disruption of Cbs perturbs redox homeostasis and reduces cysteine levels, raising the possibility that these changes may be important in the etiology of the clinical manifestations of CBS deficiency.	Cysteine	104-112	cystathionine beta-synthase	Mus musculus	61-64
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Homocysteine	62-74	cystathionine beta-synthase	Mus musculus	0-27
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Homocysteine	62-74	cystathionine beta-synthase	Mus musculus	29-32
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Serine	80-86	cystathionine beta-synthase	Mus musculus	0-27
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Serine	80-86	cystathionine beta-synthase	Mus musculus	29-32
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Cystathionine	95-108	cystathionine beta-synthase	Mus musculus	0-27
15105297-2	2004	Cystathionine beta-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine.	Cystathionine	95-108	cystathionine beta-synthase	Mus musculus	29-32
15105297-6	2004	Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P<0.02).	Methionine	33-43	cystathionine beta-synthase	Mus musculus	3-6
15105297-6	2004	Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P<0.02).	Folic Acid	49-55	cystathionine beta-synthase	Mus musculus	3-6
15105297-6	2004	Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P<0.02).	Homocysteine	96-108	cystathionine beta-synthase	Mus musculus	3-6
15105297-7	2004	CBS overexpression also significantly lowered serum cysteinylglycine (3.6 versus 2.8 micromol/L; P<0.003) levels and reduced the levels of many amino acids in the liver.	cysteinylglycine	52-68	cystathionine beta-synthase	Mus musculus	0-3
15105297-9	2004	Our results show that elevating CBS activity is an effective method to lower plasma homocysteine levels.	Homocysteine	84-96	cystathionine beta-synthase	Mus musculus	32-35
12506016-3	2003	We have generated double knock-out mice with targeted deletions of the genes for apolipoprotein E (apoE) and cystathionine beta-synthase (CBS), which converts Hcy to cystathionine.	Homocysteine	159-162	cystathionine beta-synthase	Mus musculus	109-136
15131763-1	2004	Cystathionine-beta-synthase (CBS) is required for transsulfuration of homocysteine, an amino acid implicated in vascular disease.	Homocysteine	70-82	cystathionine beta-synthase	Mus musculus	0-27
15131763-1	2004	Cystathionine-beta-synthase (CBS) is required for transsulfuration of homocysteine, an amino acid implicated in vascular disease.	Homocysteine	70-82	cystathionine beta-synthase	Mus musculus	29-32
15030387-1	2004	Deficiency in cystathionine beta synthase (CBS) leads to high plasma homocysteine concentrations and causes hyperhomocysteinemia, a common risk factor for vascular disease, stroke and possibly neurodegenerative diseases.	Homocysteine	69-81	cystathionine beta-synthase	Mus musculus	14-41
15030387-1	2004	Deficiency in cystathionine beta synthase (CBS) leads to high plasma homocysteine concentrations and causes hyperhomocysteinemia, a common risk factor for vascular disease, stroke and possibly neurodegenerative diseases.	Homocysteine	69-81	cystathionine beta-synthase	Mus musculus	43-46
12163655-0	2002	In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.	S-Adenosylmethionine	148-168	cystathionine beta-synthase	Mus musculus	7-34
12588964-1	2003	Hyperhomocysteinemia, caused by a lack of cystathionine beta synthase (CBS), leads to elevated plasma concentrations of homocysteine.	Homocysteine	5-17	cystathionine beta-synthase	Mus musculus	42-69
12588964-1	2003	Hyperhomocysteinemia, caused by a lack of cystathionine beta synthase (CBS), leads to elevated plasma concentrations of homocysteine.	Homocysteine	5-17	cystathionine beta-synthase	Mus musculus	71-74
12358731-1	2002	Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Mus musculus	91-118
12358731-1	2002	Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Mus musculus	91-118
12358731-1	2002	Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain.	Cysteine	66-76	cystathionine beta-synthase	Mus musculus	91-118
12163655-2	2002	The present study was undertaken to assess the effect of elevated plasma total homocysteine caused by cystathionine beta-synthase deficiency on one-carbon metabolism in 10 homozygous mutant mice and 10 age- and sex-matched wild-type mice.	Homocysteine	79-91	cystathionine beta-synthase	Mus musculus	102-129
12163655-2	2002	The present study was undertaken to assess the effect of elevated plasma total homocysteine caused by cystathionine beta-synthase deficiency on one-carbon metabolism in 10 homozygous mutant mice and 10 age- and sex-matched wild-type mice.	Carbon	148-154	cystathionine beta-synthase	Mus musculus	102-129
12163655-9	2002	The results of this study are consistent with the predicted role of cystathionine beta-synthase in the regulation of plasma total homocysteine levels and tissue S-adenosylhomocysteine levels.	Homocysteine	130-142	cystathionine beta-synthase	Mus musculus	68-95
12163655-9	2002	The results of this study are consistent with the predicted role of cystathionine beta-synthase in the regulation of plasma total homocysteine levels and tissue S-adenosylhomocysteine levels.	S-Adenosylhomocysteine	161-183	cystathionine beta-synthase	Mus musculus	68-95
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Mus musculus	12-39
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Mus musculus	41-44
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Mus musculus	82-85
11103808-6	2000	Severe combined immunodeficient mice implanted with CBS-transfected CEM cells demonstrated greater responsiveness to therapy, reflected in significantly prolonged survivals after ara-C administration compared with mice implanted with wild-type cells and treated with the same dosage schedule.	Cytarabine	179-184	cystathionine beta-synthase	Mus musculus	52-55
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Mus musculus	12-39
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Mus musculus	41-44
11978815-3	2002	Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation.	Glutamic Acid	202-213	cystathionine beta-synthase	Mus musculus	41-44
11978815-6	2002	These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Mus musculus	51-54
11697546-3	2001	In mouse peritoneal macrophages stimulated with lipopolysaccharide, HIP-4 and HIP-5 inhibited nitrite production without affecting prostaglandin E2 (PGE2) accumulation.	Nitrites	94-101	cystathionine beta-synthase	Mus musculus	68-73
11697546-4	2001	HIP-4 was also active in the zymosan-injected mouse air pouch model (at 100 nmol/pouch), with significant reductions in leucocyte migration and PGE2 and leukotriene B4 levels in the air pouch exudate.	Zymosan	29-36	cystathionine beta-synthase	Mus musculus	0-5
11697546-4	2001	HIP-4 was also active in the zymosan-injected mouse air pouch model (at 100 nmol/pouch), with significant reductions in leucocyte migration and PGE2 and leukotriene B4 levels in the air pouch exudate.	Dinoprostone	144-148	cystathionine beta-synthase	Mus musculus	0-5
11697546-4	2001	HIP-4 was also active in the zymosan-injected mouse air pouch model (at 100 nmol/pouch), with significant reductions in leucocyte migration and PGE2 and leukotriene B4 levels in the air pouch exudate.	Leukotriene B4	153-167	cystathionine beta-synthase	Mus musculus	0-5
11697546-5	2001	To confirm the anti-inflammatory effects of this compound, we tested HIP-4 orally (10-40 mg kg(-1)) on carrageenan mouse-paw oedema where it exerted a dose-dependent inhibition of paw swelling with significant reductions of myeloperoxidase and elastase activity and PGE2 levels in paw homogenates.	Dinoprostone	266-270	cystathionine beta-synthase	Mus musculus	69-74
10953023-4	2000	CBS(-/+) mice demonstrated impaired acetylcholine-induced aortic relaxation and a paradoxical vasoconstriction of mesenteric microvessels in response to superfusion of methacholine and bradykinin.	Acetylcholine	36-49	cystathionine beta-synthase	Mus musculus	0-3
10953023-4	2000	CBS(-/+) mice demonstrated impaired acetylcholine-induced aortic relaxation and a paradoxical vasoconstriction of mesenteric microvessels in response to superfusion of methacholine and bradykinin.	Methacholine Chloride	168-180	cystathionine beta-synthase	Mus musculus	0-3
10953023-5	2000	Cyclic GMP accumulation following acetylcholine treatment was also impaired in isolated aortic segments from CBS(-/+) mice, but aortic relaxation and mesenteric arteriolar dilation in response to sodium nitroprusside were similar to wild-type.	Cyclic GMP	0-10	cystathionine beta-synthase	Mus musculus	109-112
10953023-5	2000	Cyclic GMP accumulation following acetylcholine treatment was also impaired in isolated aortic segments from CBS(-/+) mice, but aortic relaxation and mesenteric arteriolar dilation in response to sodium nitroprusside were similar to wild-type.	Acetylcholine	34-47	cystathionine beta-synthase	Mus musculus	109-112
10953023-6	2000	Plasma levels of 8-epi-PGF(2alpha) (8-IP) were somewhat increased in CBS(-/+) mice, but liver levels of 8-IP and phospholipid hydroperoxides, another marker of oxidative stress, were normal.	8-epi-pgf	17-26	cystathionine beta-synthase	Mus musculus	69-72
10953023-6	2000	Plasma levels of 8-epi-PGF(2alpha) (8-IP) were somewhat increased in CBS(-/+) mice, but liver levels of 8-IP and phospholipid hydroperoxides, another marker of oxidative stress, were normal.	8-epi-prostaglandin F2alpha	36-40	cystathionine beta-synthase	Mus musculus	69-72
10953023-7	2000	Aortic tissue from CBS(-/+) mice also demonstrated greater superoxide production and greater immunostaining for 3-nitrotyrosine, particularly on the endothelial surface.	Superoxides	59-69	cystathionine beta-synthase	Mus musculus	19-22
10953023-7	2000	Aortic tissue from CBS(-/+) mice also demonstrated greater superoxide production and greater immunostaining for 3-nitrotyrosine, particularly on the endothelial surface.	3-nitrotyrosine	112-127	cystathionine beta-synthase	Mus musculus	19-22
10953023-9	2000	Hence, mild hyperhomocysteinemia due to reduced CBS expression impairs endothelium-dependent vasodilation, likely due to impaired nitric oxide bioactivity, and increased oxidative stress apparently contributes to inactivating nitric oxide in chronic, mild hyperhomocysteinemia.	Nitric Oxide	130-142	cystathionine beta-synthase	Mus musculus	48-51
34943052-3	2021	Binge alcohol (5 g/kg every 12 h, 3 doses) reduced the concentration of cysteine and glutathione (GSH) and decreased expression of cystathionine beta-synthase (CbetaS), cystathionine gamma-lyase (CgammaL), and glutamate cysteine ligase catalytic subunit (GCLC) in the livers of male C57BL/6 mice.	Alcohols	6-13	cystathionine beta-synthase	Mus musculus	131-158
34396581-11	2021	Furthermore, exercise training restored the STZ-mediated downregulation of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) and the reduced renal H2 S production.	Streptozocin	44-47	cystathionine beta-synthase	Mus musculus	75-102
34396581-11	2021	Furthermore, exercise training restored the STZ-mediated downregulation of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) and the reduced renal H2 S production.	Streptozocin	44-47	cystathionine beta-synthase	Mus musculus	104-107
34413167-0	2021	Cystathionine beta-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis.	tregs	78-83	cystathionine beta-synthase	Mus musculus	0-27
34413167-2	2021	Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation.	Hydrogen Sulfide	69-85	cystathionine beta-synthase	Mus musculus	41-68
34413167-2	2021	Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation.	Hydrogen Sulfide	69-85	cystathionine beta-synthase	Mus musculus	87-90
34413167-2	2021	Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation.	Deuterium	91-94	cystathionine beta-synthase	Mus musculus	41-68
34413167-2	2021	Accumulating evidence has shown that the cystathionine beta-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation.	Deuterium	91-94	cystathionine beta-synthase	Mus musculus	87-90
34413167-10	2021	Activation of the Cbs/H2S axis also reduced the abundance of tumor-infiltrating Tregs, while Cbs deficiency promoted Tregs-mediated immune evasion and boosted tumor growth in Cbs heterozygous knockout mice.	Deuterium	22-25	cystathionine beta-synthase	Mus musculus	18-21
34413167-10	2021	Activation of the Cbs/H2S axis also reduced the abundance of tumor-infiltrating Tregs, while Cbs deficiency promoted Tregs-mediated immune evasion and boosted tumor growth in Cbs heterozygous knockout mice.	tregs	80-85	cystathionine beta-synthase	Mus musculus	18-21
34413167-11	2021	Mechanistically, CBS facilitated the expression cleaved Caspase-3 in tumor cells, and on the other hand, suppressed Foxp3 expression in Tregs via inactivating IL-6/STAT3 pathway.	tregs	136-141	cystathionine beta-synthase	Mus musculus	17-20
34413167-13	2021	Additionally, miR-24-3p was proven to be an upstream suppressor of CBS in HCC.	mir-24-3p	14-23	cystathionine beta-synthase	Mus musculus	67-70
34283874-0	2021	CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB.	Deuterium	12-15	cystathionine beta-synthase	Mus musculus	0-3
34283874-0	2021	CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB.	Iron	82-86	cystathionine beta-synthase	Mus musculus	0-3
34283874-4	2021	We found that degradation of L-cysteine by putative cystathionine beta-synthase (CBS) is the major source of endogenous H2S in V. cholerae.	Cysteine	29-39	cystathionine beta-synthase	Mus musculus	81-84
34283874-4	2021	We found that degradation of L-cysteine by putative cystathionine beta-synthase (CBS) is the major source of endogenous H2S in V. cholerae.	Deuterium	120-123	cystathionine beta-synthase	Mus musculus	81-84
34283874-5	2021	Our results indicate that intracellular H2S level has a positive correlation with cbs expression, while the enhanced H2S production can render V. cholerae cells less susceptible to H2O2 in vitro.	Deuterium	40-43	cystathionine beta-synthase	Mus musculus	82-85
34283874-5	2021	Our results indicate that intracellular H2S level has a positive correlation with cbs expression, while the enhanced H2S production can render V. cholerae cells less susceptible to H2O2 in vitro.	Deuterium	117-120	cystathionine beta-synthase	Mus musculus	82-85
34283874-5	2021	Our results indicate that intracellular H2S level has a positive correlation with cbs expression, while the enhanced H2S production can render V. cholerae cells less susceptible to H2O2 in vitro.	Hydrogen Peroxide	181-185	cystathionine beta-synthase	Mus musculus	82-85
34283874-6	2021	Using proteome analysis and real-time qPCR assay, we found that cbs expression could stimulate the expression of several enzymatic antioxidants, including reactive oxygen species (ROS) detoxifying enzymes SodB, KatG and AhpC, the DNA protective protein DPS and the protein redox regulator Trx1.	Reactive Oxygen Species	155-178	cystathionine beta-synthase	Mus musculus	64-67
34283874-6	2021	Using proteome analysis and real-time qPCR assay, we found that cbs expression could stimulate the expression of several enzymatic antioxidants, including reactive oxygen species (ROS) detoxifying enzymes SodB, KatG and AhpC, the DNA protective protein DPS and the protein redox regulator Trx1.	Reactive Oxygen Species	180-183	cystathionine beta-synthase	Mus musculus	64-67
34283874-7	2021	Assays of ROS detoxification capacities revealed that CBS-derived H2S could promote catalase activity at the post-translational level, especially for KatB, which serves as an important way that endogenous H2S participates in H2O2 detoxification.	Reactive Oxygen Species	10-13	cystathionine beta-synthase	Mus musculus	54-57
34283874-7	2021	Assays of ROS detoxification capacities revealed that CBS-derived H2S could promote catalase activity at the post-translational level, especially for KatB, which serves as an important way that endogenous H2S participates in H2O2 detoxification.	Deuterium	66-69	cystathionine beta-synthase	Mus musculus	54-57
34283874-7	2021	Assays of ROS detoxification capacities revealed that CBS-derived H2S could promote catalase activity at the post-translational level, especially for KatB, which serves as an important way that endogenous H2S participates in H2O2 detoxification.	Deuterium	205-208	cystathionine beta-synthase	Mus musculus	54-57
34283874-7	2021	Assays of ROS detoxification capacities revealed that CBS-derived H2S could promote catalase activity at the post-translational level, especially for KatB, which serves as an important way that endogenous H2S participates in H2O2 detoxification.	Hydrogen Peroxide	225-229	cystathionine beta-synthase	Mus musculus	54-57
34283874-10	2021	Herein, we proposed that V. cholerae regulates CBS-dependent H2S production for better survival and proliferation under ROS stress.	Deuterium	61-64	cystathionine beta-synthase	Mus musculus	47-50
34283874-10	2021	Herein, we proposed that V. cholerae regulates CBS-dependent H2S production for better survival and proliferation under ROS stress.	Reactive Oxygen Species	120-123	cystathionine beta-synthase	Mus musculus	47-50
10993757-0	2000	Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice.	Folic Acid	0-6	cystathionine beta-synthase	Mus musculus	70-97
10993757-5	2000	Plasma total homocysteine was 5.3 +/- 0.7 microM in CBS +/+ mice and 6.4 +/- 0.6 microM in CBS +/- mice (P = 0.3) given the control diet.	Homocysteine	13-25	cystathionine beta-synthase	Mus musculus	52-55
10993757-6	2000	Plasma total homocysteine was 11.6 +/- 4.5 microM in CBS +/+ mice and 25.1 +/- 3.2 microM in CBS +/- mice (P = 0.004) given a low-folate diet.	Homocysteine	13-25	cystathionine beta-synthase	Mus musculus	53-56
10993757-8	2000	In contrast, in mice fed a low-folate diet, maximal relaxation to acetylcholine was markedly impaired in CBS +/- mice (58 +/- 9%) compared with CBS +/+ mice (84 +/- 4%) (P = 0.01).	Folic Acid	31-37	cystathionine beta-synthase	Mus musculus	105-108
10993757-8	2000	In contrast, in mice fed a low-folate diet, maximal relaxation to acetylcholine was markedly impaired in CBS +/- mice (58 +/- 9%) compared with CBS +/+ mice (84 +/- 4%) (P = 0.01).	Acetylcholine	66-79	cystathionine beta-synthase	Mus musculus	105-108
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Glucose	58-65	cystathionine beta-synthase	Mus musculus	131-158
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Glucose	58-65	cystathionine beta-synthase	Mus musculus	160-163
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Deuterium	101-104	cystathionine beta-synthase	Mus musculus	131-158
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Deuterium	101-104	cystathionine beta-synthase	Mus musculus	160-163
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	sodium bisulfide	22-41	cystathionine beta-synthase	Mus musculus	173-176
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	sodium bisulfide	43-47	cystathionine beta-synthase	Mus musculus	173-176
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	S-Adenosylmethionine	65-85	cystathionine beta-synthase	Mus musculus	120-123
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	S-Adenosylmethionine	65-85	cystathionine beta-synthase	Mus musculus	173-176
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	Glucose	139-146	cystathionine beta-synthase	Mus musculus	120-123
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	Glucose	139-146	cystathionine beta-synthase	Mus musculus	173-176
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	Deuterium	181-184	cystathionine beta-synthase	Mus musculus	120-123
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	Aminooxyacetic Acid	135-154	cystathionine beta-synthase	Mus musculus	91-118
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	Aminooxyacetic Acid	156-160	cystathionine beta-synthase	Mus musculus	91-118
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	Cysteine	267-277	cystathionine beta-synthase	Mus musculus	91-118
34902580-5	2022	In addition, cystathionine-gamma-lyase (CSE) inhibitor D,L-propargylglycine (PAG, 10-2 M), cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-2 M), and the combination of these inhibitors significantly reduced the relaxant responses induced by l-cysteine and BRL 37344.	BRL 37344	282-291	cystathionine beta-synthase	Mus musculus	91-118
34952931-10	2022	Further analysis at the molecular level validated a positive feedback loop between the CBS-H2S axis and VEGF.	Deuterium	91-94	cystathionine beta-synthase	Mus musculus	87-90
34952931-11	2022	CONCLUSIONS: Endogenous H2S promotes angiogenesis and metastasis in colon cancer, and targeting the positive feedback loop between the CBS-H2S axis and VEGF can effectively intervene in liver metastasis of colon cancer.	Deuterium	24-27	cystathionine beta-synthase	Mus musculus	135-138
34952931-11	2022	CONCLUSIONS: Endogenous H2S promotes angiogenesis and metastasis in colon cancer, and targeting the positive feedback loop between the CBS-H2S axis and VEGF can effectively intervene in liver metastasis of colon cancer.	Deuterium	139-142	cystathionine beta-synthase	Mus musculus	135-138
34795411-0	2021	ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway.	5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	0-6	cystathionine beta-synthase	Mus musculus	74-77
34795411-9	2021	Moreover, after ADT-OH treatment, melanoma cells showed abnormal expression of the H2S-producing enzymes CSE/CBS and the AKT signaling pathways.	5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	16-22	cystathionine beta-synthase	Mus musculus	109-112
34795411-9	2021	Moreover, after ADT-OH treatment, melanoma cells showed abnormal expression of the H2S-producing enzymes CSE/CBS and the AKT signaling pathways.	Deuterium	83-86	cystathionine beta-synthase	Mus musculus	109-112
34795411-11	2021	Collectively, these results demonstrate that ADT-OH inhibits the EMT process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity.	5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	45-51	cystathionine beta-synthase	Mus musculus	118-121
34853730-3	2021	Here, we found that lncRNA TGFB3-AS1 was highly expressed in macrophages treated with Hcy and the peripheral blood monocytes from cystathionine beta-synthase heterozygous knockout (CBS +/-) mice with a high-methionine diet using lncRNA microarray.	Methionine	207-217	cystathionine beta-synthase	Mus musculus	130-157
34528713-1	2021	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy).	Homocysteine	142-154	cystathionine beta-synthase	Mus musculus	0-27
34528713-1	2021	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy).	thcy	156-160	cystathionine beta-synthase	Mus musculus	0-27
33949005-1	2021	Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine.	Homocysteine	97-109	cystathionine beta-synthase	Mus musculus	0-27
33949005-1	2021	Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine.	Homocysteine	97-109	cystathionine beta-synthase	Mus musculus	29-32
33949005-1	2021	Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine.	Cystathionine	113-126	cystathionine beta-synthase	Mus musculus	0-27
33949005-1	2021	Cystathionine beta-synthase (CBS) is a key enzyme of the trans-sulfuration pathway that converts homocysteine to cystathionine.	Cystathionine	113-126	cystathionine beta-synthase	Mus musculus	29-32
33949005-2	2021	Loss of CBS activity due to mutation results in CBS deficiency, an inborn error of metabolism characterized by extreme elevation of plasma total homocysteine (tHcy).	Homocysteine	145-157	cystathionine beta-synthase	Mus musculus	8-11
33949005-2	2021	Loss of CBS activity due to mutation results in CBS deficiency, an inborn error of metabolism characterized by extreme elevation of plasma total homocysteine (tHcy).	thcy	159-163	cystathionine beta-synthase	Mus musculus	8-11
33949005-6	2021	In serum, we observe similar elevations in tHcy in both Tg-G307S Cbs-/- and Tg-I278T Cbs-/- compared to control animals, but methionine is much more severely elevated in Tg-G307S Cbs-/- mice.	Methionine	125-135	cystathionine beta-synthase	Mus musculus	179-182
33949005-7	2021	Large scale metabolomic analysis of liver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in Tg-G307S Cbs-/- animals, along with significant differences in several other metabolites including hexoses, amino acids, other amines, lipids, and carboxylic acids.	Methionine	68-78	cystathionine beta-synthase	Mus musculus	148-151
33949005-7	2021	Large scale metabolomic analysis of liver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in Tg-G307S Cbs-/- animals, along with significant differences in several other metabolites including hexoses, amino acids, other amines, lipids, and carboxylic acids.	methionine sulfoxide	83-103	cystathionine beta-synthase	Mus musculus	148-151
33949005-7	2021	Large scale metabolomic analysis of liver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in Tg-G307S Cbs-/- animals, along with significant differences in several other metabolites including hexoses, amino acids, other amines, lipids, and carboxylic acids.	Thioguanine	139-141	cystathionine beta-synthase	Mus musculus	148-151
33949005-8	2021	Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis.	Methionine	111-121	cystathionine beta-synthase	Mus musculus	77-80
33949005-8	2021	Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis.	Urea	199-203	cystathionine beta-synthase	Mus musculus	77-80
33949005-8	2021	Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis.	Trichloroacetic Acid	211-214	cystathionine beta-synthase	Mus musculus	77-80
33949005-8	2021	Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis.	Phosphatidylcholines	243-262	cystathionine beta-synthase	Mus musculus	77-80